JP2007057321A - Clinical examination system, clinical examination method, clinical examination program and recording medium - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To shorten an examination executing period in clinical examination such as multiallergen. <P>SOLUTION: The clinical examination system 100 is equipped with a multi-item examination part 103, a specific item extracting part 104, and a specific item examination part 105. In the multi-item examination part 103, the allergy examination of a multi-item using a mixture of a plurality of allergens is performed with respect to a specimen. In the specific item extracting part 104, the specific allergen contained in the mixture of a plurality of the allergens is extracted on the basis of the result of the allergy examination of the multi-item performed in the multi-item examination part 103 to form the data of the examination item of the allergy examination of the specific item using the specific allergen. In the specific item examination part 105, the allergy examination of the specific item using the specific allergen is performed with respect to the specimen on the basis of the data of the examination item of the allergy examination of the specific item formed in the specific item extracting part 104. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a clinical test apparatus, a clinical test method, a clinical test program, and a recording medium used in hospitals, clinical test institutions, and the like.

  An allergen test that identifies a patient's allergy is a multi-allergen test that is performed when it is difficult to identify a suspicious allergen based on patient symptoms or patient interviews. In the multi-allergen test, first, a multi-item test is performed using a mixture of five or six types of allergens having a relatively high probability as a cause of dermatitis, rhinitis, asthma and the like as a test item. When the multi-item test results in a positive test, the specific IgE item is tested again with each allergen (single allergen) contained in the allergen mixture as the test item.

  Conventionally, in conducting clinical tests including the above-mentioned multiallergen tests, clinical laboratories such as hospitals use test specimens for the purpose of improving the efficiency of clinical tests, improving processing capacity, and reducing costs. A clinical test apparatus composed of a sample test apparatus for testing a certain blood (hereinafter abbreviated as a sample) and a clinical test information processing apparatus for controlling data related to the test is used (for example, see Patent Document 1 below). ).

JP 2002-90375 A

  However, in the above-described prior art, since some processes such as judgment of the result of a clinical test are performed manually by a laboratory technician or the like, the process is much more than that performed by a computer such as a clinical test information processing apparatus. It takes time. Therefore, there is a problem that it takes one hour or more from the preparation of the inspection until the final result is judged.

  In addition, in the above-described prior art, a laboratory technician or the like cannot inspect a sample of the next patient during a period in which one patient is inspected. Therefore, in a large-scale hospital having a large number of patients, a lot of time and labor are required to perform clinical tests on a large number of patients.

  The above-mentioned problems in the prior art are the same in the multi-allergen test. In the multi-allergen test, in particular, it takes one hour or more to judge the test result after the multi-item test is first performed. Therefore, it is difficult to perform the next specific IgE item inspection during the day. Therefore, the patient must go home once after conducting a multi-item test, visit the clinical laboratory again later, collect blood once again, and undergo a specific IgE test. The problem is that it puts a heavy burden on the cost, physical and mental.

  In order to eliminate the above-described problems caused by the prior art, the present invention can shorten a test period and reduce a burden on a patient in a clinical test in which different tests such as a multi-allergen test are performed in stages. Another object is to provide a clinical test method, a clinical test program, and a recording medium.

  In order to solve the above-described problems and achieve the object, the clinical test apparatus according to the invention of claim 1 includes a multi-item test means for performing a multi-item allergy test on a specimen using a mixture of a plurality of allergens, Based on the results of the multi-item allergen test performed by the multi-item test means, a specific allergen is extracted by extracting a specific allergen contained in the mixture of the plurality of allergens. Specific item extraction means for generating test item information, and using the specific allergen for the specimen based on the information on the test item for the allergy test of the specific item generated by the specific item extraction means And a specific item inspection means for performing an allergy test for the specific item.

  According to a second aspect of the present invention, there is provided a clinical testing apparatus according to the first aspect of the present invention, which is related to information on test items when performing the multi-item allergy test and test items of the multi-item allergy test. Inspection item information holding means for holding information on allergic test items of the specific item, wherein the specific item extracting means is a test for the multi-item allergy test held by the test item information holding unit. The information of the test item used for the multi-item allergy test is selected from the item information, and the allergy test of the specific item corresponding to the result of the multi-item allergy test performed by the multi-item test means is selected. A specific allergen is extracted by further selecting information on the examination item.

  According to a third aspect of the present invention, there is provided a clinical testing apparatus according to the first or second aspect of the present invention, wherein the allergen is based on the result of the allergy test for the specific item performed by the specific item inspection means. A result judging means for judging the result of the test; and a result output means for outputting the result of the multi-allergen test based on the result of the multi-allergen test judged by the result judging means. And

  The clinical examination apparatus according to a fourth aspect of the present invention is the clinical examination apparatus according to any one of the first to third aspects, wherein the multi-item inspection means uses the specimen used for the multi-item allergy test. A specimen transport means for transporting to the specific item inspection means, wherein the specific item inspection means performs the allergy test for the specific item using the specimen used for the multi-item allergy test transported by the sample transport means. It is characterized by performing.

  The clinical examination apparatus according to the invention of claim 5 is the invention according to any one of claims 1 to 4, wherein the multi-item allergy test by the multi-item test means and the specific item test are performed. The allergy test for the specific item by means is performed using the same specimen testing unit, the allergy test for the multi-item performed by the multi-item test unit, and the allergy of the specific item performed by the specific item test unit Each of the tests is characterized by testing the sample testing unit at different timings.

  Further, the clinical test method according to the invention of claim 6 includes a multi-item test step of performing a multi-item allergy test on a specimen using a mixture of a plurality of allergens, and the multi-item test step performed by the multi-item test step. A specific item for extracting a specific allergen contained in the mixture of the plurality of allergens based on the result of the allergy test of the item and generating information on the test item of the specific item using the specific allergen A specific item for performing an allergy test for the specific item using the specific allergen for the specimen based on information on the test item for the allergy test for the specific item generated by the extraction step and the specific item extraction step And an inspection process.

  According to a seventh aspect of the present invention, a clinical examination program causes a computer to execute the clinical examination method according to the sixth aspect.

  A recording medium according to an eighth aspect of the invention is readable by a computer in which the clinical test program according to the seventh aspect is recorded.

  According to the present invention, based on the result of the multi-item allergen test, a specific allergen contained in a mixture of a plurality of allergens is extracted, and information on the test item of the specific item allergy test using the specific allergen Since the allergy test of a specific item using a specific allergen is performed, the allergy test can be efficiently performed in a short time just by collecting blood once from the patient.

  Exemplary embodiments of a clinical test apparatus, a clinical test method, a clinical test program, and a recording medium according to the present invention will be described below in detail with reference to the accompanying drawings.

(Embodiment 1)
(Functional configuration of clinical test apparatus 100)
First, the functional configuration of the clinical testing apparatus 100 according to the first embodiment will be described. FIG. 1 is a block diagram of a functional configuration of the clinical testing apparatus according to the first embodiment. The clinical test apparatus 100 includes a request acquisition unit 101, a test data processing unit 102, a result output unit 107, and a sample transport control unit 108.

  The request acquisition unit 101 acquires inspection execution request information requested by an inspection engineer or the like. As a method of acquiring inspection execution request information, for example, a method of acquiring inspection execution request information by inputting an inspection engineer using a keyboard, mouse, touch panel, etc., a method of acquiring inspection execution request information by reading a barcode ,and so on.

  The inspection data processing unit 102 includes a multi-item inspection unit 103, a specific item extraction unit 104, a specific item inspection unit 105, and a result determination unit 106. Based on the test execution request information acquired by the request acquisition unit 101, the test data processing unit 102 controls data of each function (multi-item test unit 103 to result determination unit 106) related to the execution of the clinical test.

  The multi-item inspection unit 103 performs multi-item inspection using a mixture of a plurality of allergens based on the inspection execution request information acquired by the request acquisition unit 101.

  The specific item extraction unit 104 extracts a specific allergen contained in a mixture of a plurality of allergens used in the multi-item test based on the result of the multi-item test performed by the multi-item test unit 103, The inspection item information of the inspection of the target IgE item is generated.

The specific item inspection unit 105 performs a specific IgE item inspection using a specific allergen based on the inspection item information of the specific IgE item inspection generated by the specific item extraction unit 104.

  The result determination unit 106 determines the final result of the clinical test based on the result of the multi-item test performed by the multi-item test unit 103 and the specific IgE item test performed by the specific item test unit 105. I do. Examples of the final test judgment of the clinical test include positive and negative.

  The result output unit 107 outputs the final result of the clinical test based on the result of the final test of the clinical test determined by the result determination unit 106 so that a laboratory technician, a doctor, or the like can confirm the result. As a method for outputting the final result of the clinical test, there are, for example, a method of outputting by a display, a method of outputting by paper through a printer, and the like.

  The sample transport control unit 108 includes a sample receiving unit 109, a sample holding unit 110, and a sample transport unit 111. The sample transport control unit 108 controls each function (sample receiving unit 109 to sample transport unit 111) related to sample transport based on the examination execution request information acquired by the request acquisition unit 101 and the like.

  The sample receiving unit 109 acquires a sample from outside the clinical test apparatus 100. Examples of the method for acquiring the specimen include a method of receiving (installing) by an inspection engineer or the like, or a method of accepting by mechanical loading using a loading device or the like.

  The sample holding unit 110 is controlled by the sample transport control unit 108 and holds the sample acquired by the sample receiving unit 109. The sample holder 110 can hold samples of a plurality of patients. In addition, as a period for holding the sample, for example, holding for a certain period, holding for each sample until the test is completed, holding until the test for all the samples held by the sample holding unit 110 is completed, and the like. is there.

  The sample transport unit 111 is controlled by the sample transport control unit 108 to carry out the sample from the sample holding unit 110 and to carry the sample into the sample testing apparatus 500 (see FIG. 2) in order to perform the test of the sample. In addition, the sample that has been tested is unloaded from the sample testing apparatus 500 and loaded into the sample holding unit 110. Furthermore, the sample transport unit 111 can transport a plurality of patient samples continuously between the sample holding unit 110 and the sample testing apparatus 500 under the control of the sample transport control unit 108.

(Hardware configuration of clinical testing apparatus 100)
Next, a hardware configuration of the clinical testing apparatus 100 according to the first embodiment will be described. FIG. 2 is a block diagram of a hardware configuration of the clinical testing apparatus according to the first embodiment. In FIG. 2, the clinical test apparatus 100 includes a clinical test information processing apparatus 200 and a sample test apparatus 500. The clinical test information processing apparatus 200 includes a CPU 201, a ROM 202, a RAM 203, an HDD (hard disk drive) 204, an HD (hard disk) 205, an FDD (flexible disk drive) 206, and an example of a removable recording medium. An FD (flexible disk) 207, a display 208, an I / F (interface) 209, a keyboard 210, a mouse 211, a scanner 212, and a printer 213 are provided. Each component is connected by a bus 214.

  Here, the CPU 201 governs overall control of the clinical test information processing apparatus 200. The ROM 202 stores a program such as a boot program. The RAM 203 is used as a work area for the CPU 201. The HDD 204 controls data read / write with respect to the HD 205 according to the control of the CPU 201. The HD 205 stores data written under the control of the HDD 204.

  The FDD 206 controls reading / writing of data with respect to the FD 207 according to the control of the CPU 201. The FD 207 stores data written under the control of the FDD 206 or causes the clinical test information processing apparatus 200 to read data stored in the FD 207.

  In addition to the FD 207, the removable recording medium may be a CD-ROM (CD-R, CD-RW), MO, DVD (Digital Versatile Disk), memory card, or the like. The display 208 displays data such as a document, an image, and function information as well as a cursor, an icon, or a tool box. As the display 208, for example, a CRT, a TFT liquid crystal display, a plasma display, or the like can be adopted.

  The I / F 209 is connected to a network such as the Internet 220 through a communication line, and is connected to other devices via this network. The I / F 209 controls a network and an internal interface, and controls data input / output from an external device. For example, a modem or a LAN adapter may be employed as the I / F 209.

  The keyboard 210 includes keys for inputting characters, numbers, various instructions, and the like, and inputs data. Moreover, a touch panel type input pad or a numeric keypad may be used. The mouse 211 performs cursor movement, range selection, window movement, size change, and the like. A trackball or a joystick may be used as long as they have the same function as a pointing device.

  The scanner 212 optically reads an image and takes in the image data into the clinical examination information processing apparatus 200. The scanner 212 may have an OCR function. The printer 213 prints image data and document data. As the printer 213, for example, a laser printer or an ink jet printer can be adopted.

  The sample testing apparatus 500 is connected to a network such as the Internet 220 through a communication line, and is connected to other apparatuses via this network. The sample testing apparatus 500 performs a sample test and takes the test result of the sample into the clinical test information processing apparatus 200. The sample testing apparatus 500 can perform either a multi-item test or a specific IgE item test.

  The functional configuration of the clinical testing apparatus 100 according to the first embodiment includes, for example, a request acquisition unit 101, a keyboard 210, a mouse 211, a scanner 212, an examination data processing unit 102, a specific item extraction unit 104, and the like. The result determination unit 106 includes a CPU 201, a ROM 202, a RAM 203, and an HDD 204, a multi-item inspection unit 103, a specific item inspection unit 105, a sample transport control unit 108, a sample receiving unit 109, and a sample holding unit 110. The sample transport unit 111 implements the functions of the sample testing apparatus 500, and the result output unit 107 implements the functions of the display 208 and the printer 213.

(Processing procedure of clinical test apparatus 100)
Next, a processing procedure of the clinical testing apparatus 100 according to the first embodiment will be described. FIG. 3 is a flowchart of a process procedure performed by the clinical testing apparatus according to the first embodiment. First, the inspection acquisition request information is acquired by the request acquisition unit 101 (step S301).

  As a method for acquiring the inspection execution request information by the request acquisition unit 101, for example, a method of acquiring inspection execution request information input by an inspection engineer or the like using the keyboard 210, the mouse 211, and the touch panel (not shown), an inspection execution request in advance. There is a method of acquiring inspection execution request information by reading a barcode in which information is stored. The test execution request information includes, for example, information for uniquely identifying a specimen (hereinafter abbreviated as specimen ID) and test items (examples of single allergens, which are test items for a multi-allergen test), as shown in FIG. -1 is used to describe an example of a multiallergen that is a test item of a multiallergen test, which will be described later with reference to FIG. 4-2), and information (name, age, sex, blood type, etc.) related to a patient. The acquired examination execution request information is stored in, for example, the HD 205 of the clinical examination information processing apparatus 200.

  Next, a sample is acquired by the sample receiving unit 109 (step S302). The acquired sample is held in the sample holding unit 110. Here, the sample is held in a state of being injected into the sample container. Further, a label such as a barcode including a sample ID is attached to the sample container. Furthermore, sample acquisition by the sample receiving unit 109 can also acquire samples from a plurality of patients at the same time. An outline of the configuration of the sample testing apparatus including the sample holding state in the sample testing apparatus 500 will be described later with reference to FIG.

  Next, the multi-item inspection unit 103 samples the sample acquired in step S302 (step S303).

  Next, the multi-item inspection unit 103 performs multi-item inspection using the sample sampled in step S303 (step S304). Here, the multi-item inspection performed by the multi-item inspection unit 103 is performed based on the inspection execution request information acquired by the request acquisition unit 101 in step S301. An example of the specimen inspection method and procedure in step S304 will be described later with reference to FIG.

  Next, based on the result of the multi-item inspection performed by the multi-item inspection unit 103 in step S304, the result determination unit 106 determines whether or not the result of the multi-item inspection is positive (step S305). In addition, an example of the determination criterion value of the test result of the multi item and the specific IgE item will be described later with reference to FIG.

  If it is determined in step S305 that the multi-item test result is positive (step S305: Yes), the specific item extraction unit 104 extracts the test item for the specific IgE item test (step S306). Here, the inspection item for the specific IgE item inspection is extracted based on the result of the multi-item inspection performed by the multi-item inspection unit 103 in step S304. An example of the test item value of the specific IgE item test based on the result of the multi-item test will be described later with reference to FIG.

  Next, the specimen obtained in step S302 is sampled by the specific item inspection unit 105 (step S307).

  Next, a specific IgE item is inspected by the specific item inspection unit 105 using the sample sampled in step S307 (step S308). Here, the specific IgE item inspection performed by the specific item inspection unit 105 is performed based on the inspection item of the specific IgE item inspection extracted by the specific item extraction unit 104 in step S306. Note that the specimen inspection method for the specific IgE item test in step S308 will also be described later with reference to FIG. 6, as in the case of the multi-item test described in step S304.

  Next, the result determination unit 106 determines the result of the examination of the specific IgE item (step S309). Then, the result determination unit 106 determines the final test result of the clinical test. The determination of the final test result of the clinical test includes the result of the specific IgE item test performed by the specific item test unit 105 in step S308 and the multi-item test performed by the multi-item test unit 103 in step S304. Based on the results of Note that an example of the criterion value of the result of the inspection of the multi-item and the specific IgE item in step S309 will be described later with reference to FIG. 8 as in the case of the multi-item inspection described in step S305.

  Next, based on the final test result of the clinical test determined by the result determination unit 106 in step S309, the result output unit 107 outputs the final test result information of the clinical test (step S310). The process according to the flowchart ends.

  If it is determined in step S305 that the multi-item test result is not positive (step S305: No), the result output unit 107 outputs the final test result information of the clinical test (step S310). The process according to the flowchart ends. Here, the final test result information of the clinical test is output based on the multi-item test result performed by the multi-item test unit 103 in step S304.

  In step S310, the final test result information output method of the clinical test includes, for example, a method of outputting using the display 208 and a method of outputting using paper via the printer 213. An example of the output of the final result of a specific clinical test will be described later with reference to FIG.

  FIG. 4A is a diagram illustrating an example of a single allergen that is an inspection item of a multi-allergen test. FIG. 4B is a diagram of an example of a multi-allergen that is a test item for a multi-allergen test. FIG. 4A includes a single allergen list 400. FIG. 4B includes a multiallergen list 410. The single allergen list 400 holds allergen classifications 401a and 401b and allergen types 402a and 402b. The multi-allergen list 410 holds multi-allergen types 411 and allergen types 412 included.

  In the multiallergen test, first, one, a plurality, or all of the suspected multiallergens are selected from the six types of multiallergen items shown in the multiallergen type 411 in the multiallergen list 410. Then, a test using the selected multi-allergen is performed. And when it becomes positive in the test | inspection using a multiallergen, the test | inspection using each single allergen shown by the kind 412 of the allergen contained is performed. As described above, the multiallergen test can identify allergens by performing tests in stages.

  For example, in the multi-allergen test, when the test of “multi-allergen” 411 in the multi-allergen type 411 is used as the test item, the test result of this multi-item becomes positive. Next, in the next specific IgE item test, among the allergen types 412 included, “Halgaya”, “Gyojishiba”, “Kamogaya”, “Oowawagaeri”, and “Ashi” are tested items. It has been shown to be used as

  FIG. 5 is a plan view showing an outline of the configuration of the sample testing apparatus. First, the configuration of the specimen testing apparatus 500 will be described. In FIG. 5, the sample testing apparatus 500 includes a sample table 510, a first reaction table 511, a second reaction table 512, a first reagent table 513, a second reagent table 514, and a first sampling probe 521 (illustrated). A second sampling probe 522 (not shown), a third sampling probe 523 (not shown), a fourth sampling probe 524 (not shown), a first agitator 531 (not shown), and laser irradiation. It is comprised by each apparatus with the apparatus 541 (illustration omitted). The operations of these constituent devices are all controlled by a control device (not shown) including the following description.

  The sample table 510 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The sample table 510 holds a plurality of sample containers 501 in which a sample is injected in an annular shape. The sample table 510 conveys the sample container 501 to a predetermined position by rotating the table. With the above-described configuration, the sample table 510 can simultaneously hold a plurality of patient containers 501 and can continuously transport the sample containers 501 to a predetermined position.

  The first reaction table 511 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The first reaction table 511 holds a plurality of first reaction containers 502 in an annular shape. The first reaction table 511 conveys the first reaction container 502 to a predetermined position by rotating the table. The first reaction table 511 can simultaneously hold a plurality of first reaction vessels 502 by the above-described configuration, and can continuously convey the first reaction vessels 502 to a predetermined position.

  The second reaction table 512 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The second reaction table 512 holds a plurality of second reaction vessels 503 in an annular shape. The second reaction table 512 conveys the second reaction container 503 to a predetermined position by rotating the table. The second reaction table 512 can simultaneously hold a plurality of second reaction vessels 503 with the above-described configuration, and can continuously convey the second reaction vessels 503 to a predetermined position.

  The first reagent table 513 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The first reagent table 513 holds a plurality of first reagent containers 504 filled with a first reagent (biotinylated allergen) in an annular shape. The first reagent table 513 conveys the first reagent container 504 to a predetermined position by rotating the table. The 1st reagent table 513 can hold | maintain the 1st reagent container 504 by which the several different 1st reagent was inject | poured by the said structure. An appropriate one can be selected and transported for each examination from among the plurality of first reagent containers 504 held.

  The second reagent table 514 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The second reagent table 514 holds a plurality of second reagent containers 505 in an annular shape into which the second reagent (HRP-labeled anti-human IgE antibody) has been injected. The second reagent table 514 conveys the second reagent container 505 to a predetermined position by rotating the table. The second reagent table 514 can hold a plurality of second reagent containers 505 into which the second reagent (HRP-labeled anti-human IgE antibody) has been injected according to the above configuration. An appropriate one can be selected and transported for each examination from among the plurality of second reagent containers 505 held.

  The first sampling probe 521 includes an arm 521a, a nozzle 521b, and an arm drive shaft 521c. The arm 521a rotates by a predetermined angle about the arm drive shaft 521c as the arm drive shaft 521c rotates by driving a motor (not shown) controlled by a control device. A nozzle 521b is attached to the lower end of the arm 521a. The nozzle 521b can suck a sample from the tip of the nozzle 521b and discharge the sample sucked from the tip of the nozzle 521b by driving a pump (not shown) controlled by a control device.

  The second sampling probe 522 includes an arm 522a, a nozzle 522b, and an arm drive shaft 522c. The arm 522a rotates by a predetermined angle about the arm drive shaft 522c as the arm drive shaft 522c rotates by driving a motor (not shown) controlled by a control device. A nozzle 522b is attached to the lower end of the arm 522a. The nozzle 522b sucks the first reagent from the tip of the nozzle 522b and discharges the first reagent sucked from the tip of the nozzle 522b by driving a pump (not shown) controlled by the control device. be able to.

  The third sampling probe 523 includes an arm 523a, a nozzle 523b, and an arm drive shaft 523c. The arm 523a rotates by a predetermined angle around the arm drive shaft 523c as the arm drive shaft 523c rotates by driving a motor (not shown) controlled by a control device. A nozzle 523b is attached to the lower end of the arm 523a. The nozzle 523b can draw a reaction liquid from the tip of the nozzle 523b and discharge the reaction liquid sucked from the tip of the nozzle 523b by driving a pump (not shown) controlled by a control device. it can.

  The fourth sampling probe 524 includes an arm 524a, a nozzle 524b, and an arm drive shaft 524c. The arm 524a rotates by a predetermined angle around the arm drive shaft 524c as the arm drive shaft 524c rotates by driving a motor (not shown) controlled by a control device. A nozzle 524b is attached to the lower end of the arm 524a. The nozzle 524b sucks the second reagent from the tip of the nozzle 524b and discharges the second reagent sucked from the tip of the nozzle 524b from the tip of the nozzle 524b by driving a pump (not shown) controlled by the control device. be able to.

  The first stirring device 531 includes an arm 531a and an air nozzle 531b. An air nozzle 531b is attached to the lower end of the arm 531a. The first stirring device 531 discharges air toward the reaction solution in the first reaction vessel 502 located below the air nozzle 531b by driving a pump (not shown) controlled by the control device, and the first reaction. The reaction solution in the container 502 can be stirred.

  The laser irradiation device 541 includes a laser irradiation device 541a and a laser irradiation unit 541b. A laser irradiation unit 541b is attached to the lower end of the laser irradiation device 541a. The laser irradiation device 541 can irradiate the laser from the laser irradiation unit 541b toward the reaction liquid in the second reaction vessel 503 positioned below and measure the reflectance of the laser.

  Of the functions of the clinical testing apparatus 100 according to the first embodiment, all of the sample receiving unit 109, the sample holding unit 110, and the sample transporting unit 111 are realized by the sample testing apparatus 500. 510 realizes the function.

  Next, the operation of the specimen testing apparatus 500 will be described. First, the specimen container 501 is located at P1 on the sample table 510.

  Next, as the sample table 510 rotates, the specimen container 501 is transported to the position P2 on the sample table 510 where the first sampling probe 521 can inhale.

  Next, the first sampling probe 521 rotates until the nozzle 521b is located directly above the sample container 501 located at P2 on the sample table 510. The nozzle 521b is inserted into the sample in the sample container 501, and the nozzle 521b sucks a predetermined amount of the sample. Subsequently, the first sampling probe 521 rotates until the nozzle 521b is located immediately above the first reaction vessel 502 located at P3 on the first reaction table 511. The nozzle 521b discharges the sample sucked from the sample container 501 into the first reaction container 502.

  Next, as the first reaction table 511 rotates, the first reaction container 502 is transported to a position P4 where the second reagent can be discharged by the second sampling probe 522 on the first reaction table 511.

  Next, the second sampling probe 522 rotates until the nozzle 522b is located immediately above the first reagent container 504 located at P5 on the first reagent table 513. The nozzle 522b is inserted into the first reagent in the first reagent container 504, and the nozzle 522b sucks a predetermined amount of the first reagent. Subsequently, the second sampling probe 522 rotates until the nozzle 522b is located immediately above the first reaction vessel 502 located at P4 on the first reaction table 511. The nozzle 522b discharges the first reagent sucked from the first reagent container 504 into the first reaction container 502. At this time, a reaction liquid is generated in the first reaction container 502 by the specimen and the first reagent.

  Next, as the first reaction table 511 rotates, the first reaction vessel 502 is transferred to a position P6 where the reaction liquid can be stirred by the first stirring device 531 on the first reaction table 511.

  Next, from the air nozzle 531b of the first stirrer 531 which is fixed immediately above the first reaction vessel 502 located at P6 on the first reaction table 511, toward the reaction solution in the first reaction vessel 502. The reaction liquid is agitated by discharging air.

  Next, as the first reaction table 511 rotates, the first reaction vessel 502 is transported to a position P7 where the third sampling probe 523 on the first reaction table 511 can suck the reaction liquid.

  Next, the third sampling probe 523 rotates until the nozzle 523b is located immediately above the first reaction vessel 502 located at P7 on the first reaction table 511. The nozzle 523b is inserted into the reaction solution in the first reaction vessel 502, and the nozzle 523b sucks the reaction solution by a predetermined amount. Subsequently, the third sampling probe 523 rotates until the nozzle 523b is located immediately above the second reaction vessel 503 located at P8 on the second reaction table 512. The nozzle 523b discharges the reaction liquid sucked from the first reaction container 502 into the second reaction container 503. At this time, a filter and a water-absorbing material in which a biotin-binding protein is supported in advance are incorporated in the second reaction vessel 503, and a block solution is injected. The biotin-binding protein and the biotinylated allergen in the reaction solution are injected. And the specific IgE antibody complex is supported on the filter.

  Next, as the second reaction table 512 rotates, the second reaction container 503 is transported to a position P9 on the second reaction table 512 where the second reagent can be discharged by the fourth sampling probe 524.

  Next, the fourth sampling probe 524 rotates until the nozzle 524b is located immediately above the second reagent container 505 located at P10 on the second reagent table 514. The nozzle 524b is inserted into the second reagent in the second reagent container 505, and the nozzle 524b sucks a predetermined amount of the second reagent. Subsequently, the fourth sampling probe 524 rotates until the nozzle 524b is located immediately above the second reaction vessel 503 located at P9 on the second reaction table 512. The nozzle 524b discharges the second reagent sucked from the second reagent container 505 into the second reaction container 503. At this time, an immune complex is generated in the second reaction container 503 by the specific IgE antibody complex and the second reagent.

  Next, as the second reaction table 512 rotates, the second reaction container 503 is transported to a position on the second reaction table 512 where the detergent can be dispensed by the detergent dispenser. Then, the cleaning agent is discharged into the second reaction vessel 503 by the cleaning agent dispensing device.

  Next, when the second reaction table 512 rotates, the second reaction container 503 is transported to a position on the second reaction table 512 where the color substrate solution can be dispensed by the color substrate solution dispensing device. . Then, the coloring substrate solution is discharged into the second reaction vessel 503 by the coloring substrate solution dispensing device.

  Next, when the second reaction table 512 is rotated, the second reaction container 503 into which the immune complex or the like has been injected is moved to a position P11 on the second reaction table 512 where the laser irradiation device 541 can perform laser irradiation. Be transported.

  Then, the laser irradiation device 541 fixed on the second reaction vessel 503 located at P11 on the second reaction table 512 irradiates the filter or the like in the second reaction vessel 503 with the laser reflectivity. Is measured.

  The above is the operation procedure of the sample testing apparatus 500 in a single sample test. In the sample testing apparatus 500, the operation of the above-described procedure is repeatedly performed, so that the first test (multi-item) for the same sample is performed. Test) and a second test (specific IgE item test). Even when the same test is performed twice, the sample used for the first test is held on the sample table 510 together with the sample container 501 and is also used for the second test. Therefore, it is not necessary to collect blood from the patient again and take the sample into the sample testing apparatus 500.

  Further, in the specimen inspection apparatus 500, even when the third and subsequent examinations are performed on the same specimen (for example, when the result of the examination cannot be determined by the first examination and the second examination), The specimen used for the second examination and the second examination is held on the sample table 510 together with the specimen container 501, and is used for the third and subsequent examinations, so blood is collected from the patient again. Thus, it is not necessary to take the sample into the sample testing apparatus 500.

  In addition, since the specimen testing apparatus 500 can hold a plurality of types of different first reagents (biotinylated allergens) for each examination item on the first reagent table 513, the specimen testing apparatus 500 uses the first reagent (biotin). By sequentially changing the type of the chemical allergen) and repeatedly performing the procedure described above, it is possible to continuously perform tests with different test items on the same specimen.

  In addition, since the specimen testing apparatus 500 can simultaneously hold specimens of a plurality of patients on the sample table 510, the specimen testing apparatus 500 sequentially changes the specimen to be examined, and repeats the operation of the procedure described above. Thus, a plurality of patient specimens can be continuously examined. Even in the case where a plurality of patient specimens are successively examined in this way, since the barcode including the specimen ID is affixed to the specimen container 501 into which the specimens are injected, the specimen containers 501 are not mistaken for each specimen. Different inspection items can be inspected.

  FIG. 6 is a diagram illustrating an example of a specimen testing method and procedure of the specimen testing performed by the specimen testing apparatus 500. In FIG. 6, the specimen inspection method and procedure 600 includes processing 610, processing 620, processing 630, processing 640, processing 650, and processing 660. First, in process 610, a specific IgE antibody complex 615 is formed in the reaction solution 614 by injecting the specimen 612 and the biotinylated allergen 613 into the first reaction vessel 611. Here, the biotinylated allergen 613 is used for each test item, such as for testing a multi-item “food multi”, testing a specific IgE item “egg white”, and testing a specific IgE item “milk”. Different types are used.

  Next, in the process 620, the block solution 623 is injected into the second reaction vessel 621 in which the filter 624 carrying the biotin-binding protein and the water absorbing material 622 are incorporated, and further the reaction containing the specific IgE antibody complex 615. Liquid 614 is injected. As a result, the specific IgE antibody complex 615 is captured by the filter 624 carrying the biotin-binding protein.

  Next, in processing 630, the immune complex 632 is converted into the specific IgE antibody complex 615 and the HRP-labeled anti-human IgE antibody 631 by injecting the HRP-labeled anti-human IgE antibody 631 into the second reaction vessel 621. It is formed.

  Next, in process 640, unreacted unnecessary allergens and the like are removed by injecting the cleaning agent 641 into the second reaction vessel 621.

  Next, in processing 650, the chromogenic substrate solution 651 is injected into the second reaction container 621, so that the chromogenic substrate solution 651 reacts with the enzyme contained in the immune complex 632 captured by the filter 624 and develops color.

  Next, in process 660, the filter 624 in the second reaction vessel 621 is irradiated with a laser 661, whereby the IgE antibody concentration is measured based on the reflectance from the filter 624.

  In the multi-allergen test, the multi-item test is first performed using the above procedure. Then, as in the multi-item test, the specific IgE item is tested using the above procedure, whereby the allergen of the specimen can be specified. Conventionally, it takes about 1 hour to inspect a sample once. However, due to advances in reagents and sample inspection apparatuses used in the inspection, it is currently about 10 to 15 minutes.

  FIG. 7 is a diagram illustrating an example of test item values for a specific IgE item test based on the multi-item test result. The table 700 holds a test item 701 for a multi-item test and a test item 702 for a specific IgE item. This table 700 is stored, for example, on the HD 205 of the clinical test information processing apparatus 200 and is used by the specific item extraction unit 104. For example, when the test item 701 of the multi-item test is “food multi”, the test item 702 of the specific IgE item test is “lampaku”, “milk”, “wheat”, “peanut”, “ It is shown that “soybean” is selected.

  FIG. 8 is a diagram illustrating an example of a determination criterion value of a result of examination of a multi item and a specific IgE item. The table 800 holds an IgE antibody concentration 801 and a determination 802. This table 800 is stored, for example, on the HD 205 of the clinical test information processing apparatus 200 and is used by the result determination unit 106.

  For example, when the IgE antibody concentration 801 is “0.34 (UA / ml) or less”, it is indicated that the result determination unit 106 determines “negative”. Further, it is indicated that when the IgE antibody concentration 801 is “0.35 (UA / ml) or more and 0.69 (UA / ml) or less”, the result judging unit 106 judges “mild positive”. It is shown that when the IgE antibody concentration 801 is “3.50 (UA / ml) or more and 17.49 (UA / ml) or less”, the result judging unit 106 judges “moderately positive”.

  FIG. 9 is a diagram illustrating an example of an output of a final result of a clinical test. FIG. 9 shows an example in which a list of results of the multi-allergen test is displayed on the display 208 (see FIG. 2) of the clinical test information processing apparatus 200. The output of the final result of the clinical test may be displayed on a display of a PC (personal computer) connected to the clinical test information processing apparatus 200 via a network, for example.

  In FIG. 9, a screen 901 shows that a patient ID 904, a name 905, an age 906, and a sex 907 are displayed as an example of information related to the patient's individual. Moreover, it shows that the inspection date 903, the state 908, the result 909, and the item 910 are displayed as an example of the information regarding the inspection. As buttons, a button 911 for displaying a detailed screen, a printout button 912, a button 913 for displaying a search screen, and a button 914 for displaying a top menu screen are displayed to indicate that the user can select them.

  For example, in the case of a patient whose patient ID 904 is “1234M”, the name 905 is “Yamada Taro”, indicating the progress of the test, the state 908 is “completed”, indicating the result of the test, and the result 909 is “positive” The item 910 indicates “egg white”.

  For example, when the user wants to know the details of the test results and the details of the information related to the patient's individual, the user can press the button 911 to display the details screen of the test results and the information related to the patient's individual. . Moreover, it can sort for each information displayed on the screen 901. For example, it is possible to preferentially display the result information of a test with a “positive” test result.

  By outputting the final result as described above, it is possible to make a consistent determination of the inspection result regardless of the skill of the inspection engineer or doctor, and to prevent a determination error. In addition, since only necessary information such as an inspection engineer or doctor who wants to know as an inspection result can be displayed, it is possible to prevent a decrease in work efficiency or confusion of the inspection engineer or doctor due to information overflow. In addition, even if you are not in a place where you can handle the clinical testing equipment during and immediately after the test, for example, you can check multiple test results at a later date. The time can be used effectively without being restricted in time.

  In the clinical testing apparatus 100 according to the first embodiment, the multi-item testing unit 103 can also simultaneously perform a plurality of different multi-item tests in parallel in step S304. For example, if you have no idea what multi-item inspection should be performed, perform the inspection of all multi-items simultaneously in parallel, and the inspection time will be the same as when one multi-item inspection is performed. Without change, all multi-item inspections can be performed and the inspection results can be generated.

  Further, in the clinical testing apparatus 100 according to the first embodiment, the specific item testing unit 105 can simultaneously test in parallel a plurality of different specific IgE items in step S308. Even in the inspection of specific IgE items in which the inspection of a plurality of different items is indispensable, by performing the inspection of a plurality of different specific IgE items in parallel at the same time, the execution time of the inspection can be reduced to one specific IgE item. All the specific IgE items can be inspected and the results of the inspection can be generated as is the case with the inspection.

  In addition, the clinical testing apparatus 100 according to the first embodiment can continuously perform clinical tests according to the procedures in steps S301 to S310 described above. Conventionally, the examination of the sample of the next patient could not be started until the result of the examination of the sample of one patient was judged manually by a laboratory technician or the like. Can be continuously inspected without waiting for the result of the inspection by an inspection engineer or the like.

  Thus, according to the clinical testing apparatus 100 according to the first embodiment, based on the result of the multi-item allergy test, a specific allergen contained in a mixture of a plurality of allergens is extracted, and the specific allergen is extracted. Since the information on the test item for the allergy test of the specific item used is generated and the allergy test for the specific item using the specific allergen is performed, the test can be efficiently performed in a short time of about 30 minutes. In addition, the specimen used for the multi-item test is retained until the specific IgE item is tested, and is used for the specific IgE item test so that the patient can visit the clinical laboratory and collect blood at one time. Can alleviate the burden on the patient.

  Furthermore, according to the clinical testing apparatus 100 according to the first embodiment, in the multi-allergen test, a plurality of patient samples can be held by the sample holding unit 110, and more than one patient can be held by the sample transport unit 111. The specimen can be continuously conveyed to the specimen testing apparatus 500, and the specimen data of a plurality of patients can be continuously processed by the examination data processing unit 102. As a result, even in a large-scale hospital with a large number of patients, multi-allergen tests of a plurality of patients can be performed continuously in a short time.

(Embodiment 2)
(Hardware configuration of clinical testing apparatus 100)
Next, a hardware configuration of the clinical testing apparatus 100 according to the second embodiment will be described. Since the functional configuration of the clinical testing apparatus 100 according to the second embodiment is the same as that of the clinical testing apparatus 100 according to the first embodiment, the description thereof is omitted. FIG. 10 is a block diagram of a hardware configuration of the clinical testing apparatus according to the second embodiment. In FIG. 10, the clinical test apparatus 100 includes a sample transport apparatus 1100 in addition to the same configuration as the clinical test apparatus 100 described in the first embodiment.

  The sample transport apparatus 1100 is connected to a network such as the Internet 220 through a communication line, and is connected to other apparatuses via this network. The sample transport apparatus 1100 can hold a large number of patient samples. The sample transport apparatus 1100 can continuously transport a large number of patient samples that are held to the sample testing apparatus 500.

  The functional configuration of the clinical testing apparatus 100 according to the second embodiment is as follows. For example, the request acquisition unit 101 includes a keyboard 210, a mouse 211, and a scanner 212, a test data processing unit 102, a specific item extraction unit 104, and the like. The result determination unit 106 includes the CPU 201, the ROM 202, the RAM 203, and the HDD 204, the multi-item inspection unit 103, the specific item inspection unit 105, the sample transport control unit 108, the sample inspection apparatus 500, and the sample receiving unit 109. The sample holding unit 110 and the sample transport unit 111 have the functions of the sample transport device 1100, and the result output unit 107 has the function of the display 208 and the printer 213.

(Processing procedure of clinical test apparatus 100)
Next, a processing procedure of the clinical testing apparatus 100 according to the second embodiment will be described. The configuration of the clinical test apparatus 100 according to the second embodiment includes a sample transport apparatus 1100 in addition to the configuration of the clinical test apparatus 100 according to the first embodiment. The processing procedure of the clinical testing apparatus 100 according to the second embodiment is the same as that of the first embodiment (see FIG. 3). In place of the sample testing apparatus 500 described above with reference to FIG. 5 of the first embodiment, the sample testing apparatus 500 and the sample transport apparatus 1100 are used.

  FIG. 11 is a plan view showing a schematic configuration of the sample testing apparatus and the sample transport apparatus. First, the configuration of the sample transport apparatus 1100 will be described. In FIG. 11, the sample transport apparatus 1100 includes a sample transport conveyor 1110, a sample input device 1120, a secondary examination buffer 1130, and a sample collection device 1140. The operations of these constituent devices are all controlled by a control device (not shown) including the following description.

  The sample transport conveyor 1110 is an annular conveyor formed by a combination of a linear conveyor and a curved conveyor, and proceeds in a certain direction by driving a motor (not shown) controlled by a control device. By moving the sample transport conveyor 1110 in a certain direction, the sample container 1101 into which the sample on the sample transport conveyor 1110 is injected is transported to a predetermined position that can be used by each component device.

  The sample loading machine 1120 includes a sample loading rack 1121 and a sample loading crane 1122 (not shown). The sample loading rack 1121 holds a plurality of sample containers 1101 into which samples are injected in a mesh shape. The specimen loading crane 1122 includes a front / rear moving rail a1122a, a front / rear moving rail b1122b, a left / right moving rail 1122c, and an arm 1122d. The front / rear moving rail a1122a and the front / rear moving rail b1122b are fixedly arranged in parallel to the left and right of the sample loading rack 1121. The left / right moving rail 1122c is vertically disposed between the front / rear moving rail a1122a and the front / rear moving rail b1122b, and both ends of the left / right moving rail 1122c are movable back and forth to the front / rear moving rail a1122a and the front / rear moving rail b1122b. Placed in. The arm 1122d is arranged so as to be movable left and right below the left and right moving rail 1122c. Although not shown, the arm 1122d can be moved up and down, and can suspend the sample container 1101 arranged on the sample loading rack 1121. With the above configuration, the sample feeder 1120 sequentially transports the plurality of sample containers 1101 arranged in the sample loading rack 1121 onto the sample transport conveyor 1110.

  The secondary inspection buffer 1130 is configured by a secondary inspection sample transport conveyor 1131. The specimen transport conveyor 1131 for secondary examination is an annular conveyor formed by a combination of a linear conveyor and a curved conveyor, and proceeds in a certain direction by driving a motor (not shown) controlled by a control device. . The sample transport conveyor 1131 for secondary examination is connected to the sample transport conveyor 1110, and transports the sample container 1101 on the conveyor to a predetermined position on the sample transport conveyor 1110 as the conveyor advances in a certain direction. With the above configuration, the secondary inspection buffer 1130 holds the specimen once inspected by the specimen inspection apparatus 500 and uses it in combination with the specimen transport conveyor 1110 to perform the second and subsequent inspections. The specimen can be transported to the specimen testing apparatus 500.

  The sample collection machine 1140 includes a sample collection rack 1141 and a sample collection crane 1142 (not shown). The sample collection rack 1141 holds a plurality of sample containers 1101 in which a sample is injected or empty. The specimen collection crane 1142 includes a front / rear moving rail a 1142a, a front / rear moving rail b 1142b, a left / right moving rail 1142c, and an arm 1142d. The front / rear moving rail a1142a and the front / rear moving rail b1142b are fixedly arranged in parallel to the left and right of the sample collection rack 1141. The left / right moving rail 1142c is vertically disposed between the front / rear moving rail a 1142a and the front / rear moving rail b 1142b, and both ends of the left / right moving rail 1142c are movable back and forth to the front / rear moving rail a 1142a and the front / rear moving rail b 1142b. Placed in. The arm 1142d is arranged at the lower part of the left and right moving rail 1142c so as to be movable left and right. Although not shown, the arm 1142d can be moved up and down and can be suspended to arrange the sample container 1101 on the sample collection rack 1141. With the above configuration, the sample collection machine 1140 completes the examination by the sample examination apparatus 500 and sequentially arranges the sample containers 1101 conveyed to a predetermined position on the sample conveyance conveyor 1110 on the sample collection rack 1141.

  Next, the configuration of the specimen testing apparatus 500 will be described. In FIG. 11, the sample testing apparatus 500 includes a first reaction table 511, a second reaction table 512, a first reagent table 513, a second reagent table 514, a first sampling probe 521 (not shown), Two sampling probes 522 (not shown), third sampling probes 523 (not shown), fourth sampling probes 524 (not shown), first stirring device 531 (not shown), and laser irradiation device 541 (not shown) ) And each device. The operations of these constituent devices are all controlled by a control device (not shown) including the following description.

  The first reaction table 511 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The first reaction table 511 holds a plurality of first reaction containers 502 in an annular shape. The first reaction table 511 conveys the first reaction container 502 to a predetermined position by rotating the table. The first reaction table 511 can simultaneously hold a plurality of first reaction vessels 502 by the above-described configuration, and can continuously convey the first reaction vessels 502 to a predetermined position.

  The second reaction table 512 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The second reaction table 512 holds a plurality of second reaction vessels 503 in an annular shape. The second reaction table 512 conveys the second reaction container 503 to a predetermined position by rotating the table. The second reaction table 512 conveys the second reaction container 503 to a predetermined position by rotating the table. The second reaction table 512 can simultaneously hold a plurality of second reaction vessels 503 with the above-described configuration, and can continuously convey the second reaction vessels 503 to a predetermined position.

  The first reagent table 513 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The first reagent table 513 holds a plurality of first reagent containers 504 filled with a first reagent (biotinylated allergen) in an annular shape. The first reagent table 513 conveys the first reagent container 504 to a predetermined position by rotating the table. The 1st reagent table 513 can hold | maintain the 1st reagent container 504 by which the several different 1st reagent was inject | poured by the said structure. An appropriate one can be selected and transported for each examination from among the plurality of first reagent containers 504 held.

  The second reagent table 514 is a circular table, and rotates in a frame-feed manner by a predetermined angle about the center of the table by driving a motor (not shown) controlled by a control device. The second reagent table 514 holds a plurality of second reagent containers 505 in an annular shape into which the second reagent (HRP-labeled anti-human IgE antibody) has been injected. The second reagent table 514 conveys the second reagent container 505 to a predetermined position by rotating the table. The second reagent table 514 can hold a plurality of second reagent containers 505 into which the second reagent (HRP-labeled anti-human IgE antibody) has been injected according to the above configuration. An appropriate one can be selected and transported for each examination from among the plurality of second reagent containers 505 held.

  The first sampling probe 521 includes an arm 521a, a nozzle 521b, and an arm drive shaft 521c. The arm 521a rotates by a predetermined angle about the arm drive shaft 521c as the arm drive shaft 521c rotates by driving a motor (not shown) controlled by a control device. A nozzle 521b is attached to the lower end of the arm 521a. The nozzle 521b can suck a sample from the tip of the nozzle 521b and discharge the sample sucked from the tip of the nozzle 521b by driving a pump (not shown) controlled by a control device.

  The second sampling probe 522 includes an arm 522a, a nozzle 522b, and an arm drive shaft 522c. The arm 522a rotates by a predetermined angle about the arm drive shaft 522c as the arm drive shaft 522c rotates by driving a motor (not shown) controlled by a control device. A nozzle 522b is attached to the lower end of the arm 522a. The nozzle 522b sucks the first reagent from the tip of the nozzle 522b and discharges the first reagent sucked from the tip of the nozzle 522b by driving a pump (not shown) controlled by the control device. be able to.

  The third sampling probe 523 includes an arm 523a, a nozzle 523b, and an arm drive shaft 523c. The arm 523a rotates by a predetermined angle around the arm drive shaft 523c as the arm drive shaft 523c rotates by driving a motor (not shown) controlled by a control device. A nozzle 523b is attached to the lower end of the arm 523a. The nozzle 523b can draw a reaction liquid from the tip of the nozzle 523b and discharge the reaction liquid sucked from the tip of the nozzle 523b by driving a pump (not shown) controlled by a control device. it can.

  The fourth sampling probe 524 includes an arm 524a, a nozzle 524b, and an arm drive shaft 524c. The arm 524a rotates by a predetermined angle around the arm drive shaft 524c as the arm drive shaft 524c rotates by driving a motor (not shown) controlled by a control device. A nozzle 524b is attached to the lower end of the arm 524a. The nozzle 524b sucks the second reagent from the tip of the nozzle 524b and discharges the second reagent sucked from the tip of the nozzle 524b from the tip of the nozzle 524b by driving a pump (not shown) controlled by the control device. be able to.

  The first stirring device 531 includes an arm 531a and an air nozzle 531b. An air nozzle 531b is attached to the lower end of the arm 531a. The first stirring device 531 discharges air toward the reaction solution in the first reaction vessel 502 located below the air nozzle 531b by driving a pump (not shown) controlled by the control device, and the first reaction. The reaction solution in the container 502 can be stirred.

  The laser irradiation device 541 includes a laser irradiation device 541a and a laser irradiation unit 541b. A laser irradiation unit 541b is attached to the lower end of the laser irradiation device 541a. The laser irradiation device 541 can irradiate the laser from the laser irradiation unit 541b toward the reaction liquid in the second reaction vessel 503 positioned below and measure the reflectance of the laser.

  Note that, among the functions of the clinical testing apparatus 100 according to the second embodiment, the sample receiving unit 109, the sample loading unit 1120, and the sample holding unit 110 are realized by the sample testing apparatus 500 and the sample transport apparatus 1100. The secondary test buffer 1130, the sample transport unit 111, and the sample transport conveyor 1110 realize their functions.

  Next, operations of the sample testing apparatus 500 and the sample transport apparatus 1100 will be described. First, the sample container 1101 is positioned at P111 on the sample loading rack 1121. Note that the sample container 1101 may be positioned at any position on the sample input rack 1121 as long as the sample container 1101 can be suspended by the sample input crane 1122.

  Next, the arm 1122d of the sample loading crane 1122 moves from the sample loading crane 1122 back and forth and to the left and right to a position directly above the sample container 1101 located on P111. Then, the arm 1122d is lowered and the sample container 1101 is suspended. Further, the arm 1122d of the sample loading crane 1122 moves from the sample loading crane 1122 back and forth and to the left and right up to the position P112 of the sample conveying conveyor 1110. In addition, the sample container 1101 is placed on the position P112 of the sample transport conveyor 1110 by lowering the arm 1122d and opening the sample container 1101.

  Next, when the conveyor of the sample transport conveyor 1110 advances, the sample container 1101 arranged on the position P112 of the sample transport conveyor 1110 is transported to the position P113 of the sample transport conveyor 1110.

  Next, the first sampling probe 521 of the sample testing apparatus 500 rotates until the nozzle 521b is positioned directly above the sample container 1101 positioned at P113 on the sample transport conveyor 1110. The nozzle 521b is inserted into the sample in the sample container 1101, and the nozzle 521b inhales a predetermined amount of the sample. Subsequently, the first sampling probe 521 rotates until the nozzle 521b is located immediately above the first reaction vessel 502 located at P3 on the first reaction table 511. The nozzle 521b discharges the sample sucked from the sample container 1101 into the first reaction container 502.

  Next, as the first reaction table 511 rotates, the first reaction container 502 is transported to a position P4 where the second reagent can be discharged by the second sampling probe 522 on the first reaction table 511.

  Next, the second sampling probe 522 rotates until the nozzle 522b is located immediately above the first reagent container 504 located at P5 on the first reagent table 513. The nozzle 522b is inserted into the first reagent in the first reagent container 504, and the nozzle 522b sucks a predetermined amount of the first reagent. Subsequently, the second sampling probe 522 rotates until the nozzle 522b is located immediately above the first reaction vessel 502 located at P4 on the first reaction table 511. The nozzle 522b discharges the first reagent sucked from the first reagent container 504 into the first reaction container 502. At this time, a reaction liquid is generated in the first reaction container 502 by the specimen and the first reagent.

  Next, as the first reaction table 511 rotates, the first reaction vessel 502 is transferred to a position P6 where the reaction liquid can be stirred by the first stirring device 531 on the first reaction table 511.

  Next, from the air nozzle 531b of the first stirrer 531 which is fixed immediately above the first reaction vessel 502 located at P6 on the first reaction table 511, toward the reaction solution in the first reaction vessel 502. The reaction liquid is agitated by discharging air.

  Next, as the first reaction table 511 rotates, the first reaction vessel 502 is transported to a position P7 where the third sampling probe 523 on the first reaction table 511 can suck the reaction liquid.

  Next, the third sampling probe 523 rotates until the nozzle 523b is located immediately above the first reaction vessel 502 located at P7 on the first reaction table 511. The nozzle 523b is inserted into the reaction solution in the first reaction vessel 502, and the nozzle 523b sucks the reaction solution by a predetermined amount. Subsequently, the third sampling probe 523 rotates until the nozzle 523b is located immediately above the second reaction vessel 503 located at P8 on the second reaction table 512. The nozzle 523b discharges the reaction liquid sucked from the first reaction container 502 into the second reaction container 503. At this time, a filter and a water-absorbing material in which a biotin-binding protein is supported in advance are incorporated in the second reaction vessel 503, and a block solution is injected. The biotin-binding protein and the biotinylated allergen in the reaction solution are injected. And the specific IgE antibody complex is supported on the filter.

  Next, as the second reaction table 512 rotates, the second reaction container 503 is transported to a position P9 on the second reaction table 512 where the second reagent can be discharged by the fourth sampling probe 524.

  Next, the fourth sampling probe 524 rotates until the nozzle 524b is located immediately above the second reagent container 505 located at P10 on the second reagent table 514. The nozzle 524b is inserted into the second reagent in the second reagent container 505, and the nozzle 524b sucks a predetermined amount of the second reagent. Subsequently, the fourth sampling probe 524 rotates until the nozzle 524b is located immediately above the second reaction vessel 503 located at P9 on the second reaction table 512. The nozzle 524b discharges the second reagent sucked from the second reagent container 505 into the second reaction container 503. At this time, an immune complex is generated in the second reaction container 503 by the specific IgE antibody complex and the second reagent.

  Next, as the second reaction table 512 rotates, the second reaction container 503 is transported to a position on the second reaction table 512 where the detergent can be dispensed by the detergent dispenser. Then, the cleaning agent is discharged into the second reaction vessel 503 by the cleaning agent dispensing device.

  Next, when the second reaction table 512 rotates, the second reaction container 503 is transported to a position on the second reaction table 512 where the color substrate solution can be dispensed by the color substrate solution dispensing device. . Then, the coloring substrate solution is discharged into the second reaction vessel 503 by the coloring substrate solution dispensing device.

  Next, when the second reaction table 512 is rotated, the second reaction container 503 into which the immune complex or the like has been injected is moved to a position P11 on the second reaction table 512 where the laser irradiation device 541 can perform laser irradiation. Be transported.

  Then, the laser irradiation device 541 fixed on the second reaction vessel 503 located at P11 on the second reaction table 512 irradiates the filter or the like in the second reaction vessel 503 with the laser reflectivity. Is measured.

  Next, after the sample is inhaled by the first sampling probe 521 of the sample testing apparatus 500, the sample container 1101 disposed at the position P113 on the sample transport conveyor 1110 advances the conveyor of the sample transport conveyor 1110. As a result, the sample is conveyed to the secondary inspection buffer 1130. The specimen container 1101 is transported to a position P114 on the secondary test specimen transport conveyor 1131 by the advance of the secondary test specimen transport conveyor 1131 connected to the specimen transport conveyor 1110. .

  Next, the specimen container 1101 that has been transported to the position P114 on the secondary inspection specimen transport conveyor 1131 is held on the secondary inspection specimen transport conveyor 1131 until it is used for the second inspection. When the second inspection is performed, the specimen container 1101 is transported to the specimen transport conveyor 1110 as the conveyor of the secondary transport specimen transport conveyor 1131 advances. Then, as the conveyor of the sample transport conveyor 1110 advances, the sample transport conveyor 1110 is transported to the position P113 of the sample transport conveyor 1110. Then, in order to perform the second test, the sample is inhaled again by the first sampling probe 521 of the sample test apparatus 500.

  Next, the sample container 1101 disposed at the position P113 on the sample transport conveyor 1110 is subjected to the sample inhalation for the second inspection by the first sampling probe 521 of the sample inspection apparatus 500. As the conveyor of the transport conveyor 1110 advances, the transport conveyor 1110 is transported to a position P115 on the sample transport conveyor 1110.

  Next, the arm 1142d of the sample collection crane 1142 moves from the sample collection crane 1142 to the front, rear, left and right to a position directly above the sample container 1101 located on the position P115 on the sample transport conveyor 1110. Then, the arm 1142d is lowered to suspend the sample container 1101. Further, the sample collection crane 1142 moves the arm 1142d of the sample collection crane 1142 back and forth and to the left and right up to a position P116 on the sample collection rack 1141. In addition, the sample container 1101 is placed at the position P116 on the sample collection rack 1141 by lowering the arm 1142d and opening the sample container 1101.

  The operation procedure of the sample testing apparatus 500 and the sample transport apparatus 1100 in the multiallergen test is as described above. In the sample testing apparatus 500 and the sample transport apparatus 1100, the first test (multi-item test) and the second test (specific IgE item test) are performed on the same sample by the procedure described above. Even when the same examination is performed twice, the specimen used for the first examination is held in the secondary examination buffer 1130 together with the specimen container 1101 and is also used for the second examination. Therefore, it is not necessary to collect blood from the patient again and take the sample into the sample transport apparatus 1100.

  Further, in the sample inspection apparatus 500 and the sample transport apparatus 1100, when the third and subsequent inspections are performed on the same sample (for example, the determination of the inspection result is impossible in the first inspection and the second inspection). However, the specimen used for the first examination and the second examination is held in the secondary examination buffer 1130 together with the specimen container 1101 and is used for the examination after the third examination. There is no need to collect blood and take the sample into the sample transport apparatus 1100.

  In addition, since the specimen testing apparatus 500 can hold a plurality of different first reagents (biotinylated allergens) for each examination item on the first reagent table 513, the specimen testing apparatus 500 and the specimen transport apparatus 1100 By sequentially changing the type of the first reagent (biotinylated allergen) and repeating the procedure described above, it is possible to continuously perform tests with different test items on the same specimen.

  Further, since the sample transport apparatus 1100 can simultaneously hold a large number of patient samples on the sample loading rack 1121, the sample testing apparatus 500 and the sample transport apparatus 1100 sequentially change the samples to be tested, and have been described above. By repeating the operation of the procedure, a large number of patient specimens can be examined continuously. Even in the case where a large number of patient samples are continuously examined in this way, since the barcode including the sample ID is affixed to the sample container 1101 into which the sample has been injected, Different inspection items can be inspected.

  As described above, according to the clinical testing apparatus 100 according to the second embodiment, the sample transport apparatus 1100 is configured so that the number of patient samples (for example, 30) that can be held by the sample testing apparatus 500 according to the first embodiment. ), A larger amount (for example, 300) of patient samples can be simultaneously held on the sample loading rack 1121. Therefore, in the sample testing apparatus 500 and the sample transport apparatus 1100, it is possible to sequentially test a large number of patient samples by sequentially changing the samples to be tested and repeating the operation of the procedure described above.

  The clinical testing method described above can be realized by executing a program prepared in advance on a computer such as a personal computer or a workstation. This program is recorded on a computer-readable recording medium such as a hard disk, a flexible disk, a CD-ROM, an MO, and a DVD, and is executed by being read from the recording medium by the computer. The program may be a transmission medium that can be distributed via a network such as the Internet.

  As described above, the clinical test apparatus, the clinical test method, the clinical test program, and the recording medium according to the present invention are useful for clinical tests performed in hospitals, clinical test institutions, and the like, and are particularly multi-allergens that perform different tests. Suitable for clinical tests such as testing.

1 is a block diagram showing a functional configuration of a clinical testing apparatus according to a first embodiment. 1 is a block diagram showing a hardware configuration of a clinical testing apparatus according to a first embodiment. 3 is a flowchart showing a processing procedure of the clinical testing apparatus according to the first embodiment; It is a figure which shows an example of the single allergen which is a test | inspection item of a multiallergen test | inspection. It is a figure which shows an example of the multiallergen which is a test | inspection item of a multiallergen test. It is a top view which shows the structure outline | summary of a sample test apparatus. It is a figure which shows an example of the test | inspection method and procedure of a sample. It is a figure which shows an example of the value of the test | inspection item of the test | inspection of a specific IgE item based on the result of the test | inspection of a multi-item. It is a figure which shows an example of the value of the criterion of the test result of a multi item and a specific IgE item. It is a figure which shows an example of the output of the final result of a clinical test. FIG. 3 is a block diagram illustrating a hardware configuration of a clinical testing apparatus according to a second embodiment. It is a top view which shows the structure outline | summary of a sample test apparatus and a sample conveyance apparatus.

Explanation of symbols

DESCRIPTION OF SYMBOLS 100 Clinical test apparatus 101 Request acquisition part 102 Test data processing part 103 Multi item test | inspection part 104 Specific item extraction part 105 Specific item test | inspection part 106 Result judgment part 107 Result output part 108 Specimen transport control part 109 Specimen acceptance part 110 Specimen holding part 111 Specimen transport unit 200 Clinical test information processing device 500 Specimen test device 1100 Specimen transport device

Claims (8)

A multi-item test means for performing a multi-item allergy test on a specimen using a mixture of a plurality of allergens;
Based on the results of the multi-item allergen test performed by the multi-item test means, a specific allergen is extracted by extracting a specific allergen contained in the mixture of the plurality of allergens. Specific item extraction means for generating information on inspection items of
Based on the information on the test item of the allergy test of the specific item generated by the specific item extraction unit, the specific item test unit that performs the allergy test of the specific item using the specific allergen for the specimen;
A clinical examination apparatus characterized by comprising: Test item information holding means for holding test item information when performing the multi-item allergy test and information on the test item of the specific item related to the multi-item allergy test ,
The specific item extraction unit selects information on the test item used for the corresponding multi-item allergy test from the information on the test item of the multi-item allergy test held by the test item information holding unit, and The specific allergen is extracted by further selecting test item information of the specific item corresponding to the result of the multi-item allergy test performed by the multi-item test means. The clinical examination apparatus according to 1. Based on the result of the allergy test of the specific item performed by the specific item test unit, a result determination unit that determines the result of the multiallergen test;
Based on the result of the multi-allergen test determined by the result determination unit, a result output unit that outputs the result of the multi-allergen test;
The clinical examination apparatus according to claim 1 or 2, further comprising: The multi-item inspection means comprises a sample transport means for transporting the sample used for the multi-item allergy test to the specific item test means,
The specific item inspection unit performs the allergy test of the specific item using the sample used for the multi-item allergy test transported by the sample transport unit. The clinical testing device according to any one of the above. The multi-item allergy test by the multi-item test means and the allergy test of the specific item by the specific item test means are performed using the same specimen test section,
The multi-item allergy test performed by the multi-item test unit and the specific item allergy test performed by the specific item test unit respectively test the specimen test unit at different timings. The clinical examination apparatus according to any one of claims 1 to 4. A multi-item test process for performing a multi-item allergy test on a specimen using a mixture of multiple allergens;
Based on the result of the multi-item allergen test performed by the multi-item test step, a specific allergen contained in the mixture of the plurality of allergens is extracted, and the specific allergy using the specific allergen is extracted. A specific item extraction process for generating inspection item information,
Based on the information on the test item of the allergy test of the specific item generated by the specific item extraction step, the specific item test step of performing the allergy test of the specific item using the specific allergen for the specimen,
A clinical testing method characterized by comprising:   A clinical test program for causing a computer to execute the clinical test method according to claim 6. A computer-readable recording medium on which the clinical test program according to claim 7 is recorded.

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