JP2007016017A - Substituted isoxazoline compound and pest control agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new pest control agent especially an insecticide or a miticide. <P>SOLUTION: The pest control agent comprises a substituted isoxazoline compound represented by general formula (1) [wherein, A<SP>1</SP>, A<SP>2</SP>and A<SP>3</SP>are C or N; G<SP>1</SP>is benzene ring or the like; G<SP>2</SP>is pyrazole ring, triazole ring, tetrazole ring or the like; X is a halogen atom, a 1-6C haloalkyl or the like; Y is a halogen atom, a 1-6C alkyl or the like; and Z<SP>a</SP>is a halogen atom, cyano, nitro, a 1-6C alkyl, -C(O)N(R<SP>2</SP>)R<SP>1</SP>, -C(S)N(R<SP>2</SP>)R<SP>1</SP>or the like] or its salt. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a novel substituted isoxazoline compound and a salt thereof, and a pest control agent comprising the compound as an active ingredient. The pest control agent in the present invention refers to the field of agriculture and horticulture or the field of livestock and hygiene (control of mammals or domestic parasites or external parasites for domestic animals and pets, and hygiene and pest control for household and commercial use. It means a pest control agent for harmful arthropods. The agrochemical in the present invention means an insecticide / acaricide, nematicide, herbicide, fungicide, etc. in the field of agriculture and horticulture.

Conventionally, regarding substituted isoxazoline compounds, it is known that 3- (4-azolyl-substituted phenyl) -5-substituted alkyl-4,5-dihydroisoxazole has antimicrobial activity and the like and is used as a medicine. (For example, see Patent Literature 1 to Patent Literature 4 and Non-Patent Literature 1). However, there is no disclosure regarding 3- (4-azolyl-substituted aryl) -5-substituted-5-substituted aryl-4,5-dihydroisoxazole compounds according to the present invention, and further, their pest control agents, in particular Their usefulness as insecticides / acaricides and as internal or ectoparasite control agents for mammals or birds is not known at all.
International Publication No. 99/041244 Pamphlet International Publication No. 01/040222 Pamphlet International Publication No. 03/035073 Pamphlet International Publication No. 2004/029066 Pamphlet Journal of Medicinal Chemistry [J. Med. Chem.] 2003, 46, 284

  The development of pest control agents for the purpose of controlling various pests such as agricultural and horticultural pests, forest pests, and hygiene pests has progressed, and a wide variety of drugs have been put to practical use to date.

  However, due to the long-term use of such drugs, in recent years, pests have acquired drug resistance, making it difficult to control with existing insecticides and fungicides that have been used. In addition, some existing pest control agents are highly toxic, or some of them remain in the environment for a long time, and the problem of disturbing the ecosystem is becoming apparent. Under such circumstances, development of a novel pest control agent having not only high pest control activity but also low toxicity and low persistence is always expected.

  As a result of intensive studies aimed at solving the above problems, the present inventors have found that the novel substituted isoxazoline compound represented by the following general formula (1) according to the present invention has excellent pest control activity, particularly insecticide The present invention was completed by discovering that it is a very useful compound that exhibits acaricidal activity and has almost no adverse effect on non-target organisms such as mammals, fish and beneficial insects.

  That is, the present invention relates to the following [1] to [10].

  [1] General formula (1):

[Wherein, A ¹ , A ² and A ³ each independently represents a carbon atom or a nitrogen atom,
G ¹ represents a benzene ring, a nitrogen-containing 6-membered aromatic heterocycle, a furan ring, a thiophene ring or a 5-membered aromatic heterocycle containing two or more heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom,
G ² represents a nitrogen-containing 5-membered aromatic heterocycle bonded with a nitrogen atom,
X is a halogen atom, nitro, azido, -SCN, -SF _5, cyano, C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁴ (C ₃ ~C ₈₎ cycloalkyl, E1～E18, optionally substituted by C ₂ -C _{6 ^{alkenyl, R 4 (C 2 ~C 6}} ) alkenyl, C ₃ ~ C ₈ cycloalkenyl, C ₃ -C ₈ halocycloalkyl cycloalkenyl, C ₂ -C ₆ alkynyl, optionally substituted by R ⁴ (C ₂ ~C _{6) ^{alkynyl, -OH, -OR 5, -OSO 2}} R 5 , -SH, -S (O) _r R ⁵ , -NH ₂ , -N (R ⁷ ) R ⁶ , -N = CHOR ⁸ , -N = C (R ⁹ ) OR ⁸ , -CHO, -C (O ) R ⁹ , -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ ,- C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -CH = NOR ¹¹ , -C (R ⁹ ) = NOR ¹¹ , M3, M11, M17, -S (O) ₂ OR ⁹ , -S (O) ₂ NH ₂ , -S (O) ₂ N (R ¹⁰ ) R ⁹ , -Si (R ^12a ) (R ^12b ) R ¹² , phenyl, (Z) Feni substituted by _p1 Or D1 to D38, and when m represents an integer of 2 or more, each X may be the same as or different from each other,
Further, when two Xs are adjacent to each other, the two adjacent Xs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ N (R ¹³ )-, -CH ₂ N (R ¹³ ) CH _2- , -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -CH ₂ CH = CH-,- OCH = CH-, -SCH = CH-, -N (R ¹³ ) CH = CH-, -OCH = N-, -SCH = N-, -N (R ¹³ ) CH = N-, -N (R ¹³ By forming N = CH-, -CH = CHCH = CH-, -OCH ₂ CH = CH-, -N = CHCH = CH-, -N = CHCH = N- or -N = CHN = CH- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each of two Xs is bonded. At this time, the hydrogen atom bonded to each carbon atom forming the ring is optionally substituted by Z. In addition, when simultaneously substituted with two or more Z, each Z may be the same as or different from each other,
Y is a halogen atom, nitro, azido, -SCN, -SF _5, cyano, C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁴ (C ₃ ~C ₈₎ cycloalkyl, E1~E18, C ₂ ~C ₆ alkinyl, optionally substituted by R ⁴ (C ₂ ~C ₆₎ alkynyl, -OH, -OR ⁵ , -OSO ₂ R ⁵ , -SH, -S (O) _r R ⁵ , -NH ₂ , -N (R ⁷ ) R ⁶ , -N (R ⁷ ) C (O) R ^9a , -N (R ⁷ ) C (O) OR ^9a , -N (R ⁷ ) C (O) SR ^9a , -N (R ⁷ ) C (S) OR ^9a , -N (R ⁷ ) C (S) SR ^9a , -N (R ⁷ ) S (O) ₂ R ^9a , -N = CHOR ⁸ , -N = C (R ⁹ ) OR ⁸ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R _{^{9, -C (S) NH 2}} , -C (S) N (R 10) R 9, -Si (R 12a) (R 12b) R 12, phenyl, phenyl or D1~ substituted by (Z) _p1 When Y represents an integer of 2 or more, each Y may be the same as or different from each other;
Further, when two Ys are adjacent to each other, the two adjacent Ys are —CH ₂ CH ₂ CH ₂ —, —CH ₂ CH ₂ O—, —CH ₂ OCH ₂ —, —OCH ₂ O—, —CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -SCH ₂ S-, -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH ₂ -,- By forming CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -SCH ₂ CH ₂ S-, -OCH = N- or -SCH = N- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each Y is bonded, and at this time, the hydrogen atom bonded to each carbon atom forming the ring may be optionally substituted by Z Furthermore, when two or more Z are substituted at the same time, each Z may be the same as or different from each other,
Z ^a is a halogen atom, cyano, nitro, optionally substituted by C ₁ -C _{6 ^{alkyl, R 4 (C 1 ~C 6}} ) ^{alkyl, -OH, -OR 5, -OS (} O) 2 R 5 , -SH, -S (O) _r R ⁵ , -NH ₂ , -N (R ⁷ ) R ⁶ , -CHO, -C (O) R ⁹ , -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) N (R ² ) R ¹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) N (R ² ) R ¹ , -CH = NOR ¹¹ , -C (R ⁹ ) = NOR ¹¹ , M3, M11, M17, -S (O) ₂ NH ₂ , -S (O) ₂ N (R ¹⁰ ) R ⁹ , phenyl or (Z) _p1 phenyl, when p represents an integer of 2 or more, each Z ^a may be the even or different from each other the same as each other,
Further, two Z ^a is when the adjacent two Z ^a adjacent, may form a fused ring by forming a -CH = CH-CH = CH-, this time, to form a ring each hydrogen halogen atoms bonded to carbon atoms, cyano group, nitro group, C ₁ -C ₄ alkyl group, C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio groups Optionally substituted by
R ¹ is hydrogen atom, cyano, optionally substituted by C ₁ -C ₁₂ alkyl, optionally substituted by R ¹⁴ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, R ¹⁴ ( C ₃ -C ₁₂₎ cycloalkyl, E2~E5, E8, E11~E14, E17 , C 3 ~C 12 alkenyl, optionally substituted by R ¹⁴ (C ₃ ~C ₁₂₎ alkenyl, C ₃ -C ₁₂ cycloalkenyl, C ₃ -C ₁₂ halo cycloalkenyl, C ₃ -C ₁₂ alkynyl, optionally substituted by R ¹⁴ (C ₃ ~C ₁₂₎ alkynyl, -CHO, -C (O) R 15, -C ( R ¹⁶ ) = NOR ¹⁵ , -C (O) OR ¹⁵ , -C (O) SR ¹⁵ , -C (O) NH ₂ , -C (O) N (R ¹⁶ ) R ¹⁵ , -C (O) NHC (O) R ¹⁵ , -C (O) N (R ¹⁶ ) C (O) OR ¹⁵ , -C (S) OR ¹⁵ , -C (S) SR ¹⁵ , -C (S) NH ₂ , -C ( S) N (R ¹⁶ ) R ¹⁵ , M7, M9, M13, M15, -OR ¹⁷ , -N (R ¹⁸ ) R ¹⁷ , -N = C (R ^17b ) R ^17a , -SR ¹⁵ , -S (O ) ₂ R ¹⁵ , -SN (R ²⁰ ) R ¹⁹ , -S (O) ₂ N (R ¹⁶ ) R ¹⁵ , phenyl, phenyl substituted by (Z) _p1 , D1-D25 or D27-D38 And
R ² is a hydrogen atom, cyano, C ₁ -C ₁₂ alkyl, (C ₁ -C ₁₂ ) alkyl, C ₃ -C ₁₂ cycloalkyl, C ₃ -C ₁₂ alkenyl, C ₃ optionally substituted by R ^14a -C ₁₂ haloalkenyl, C ₃ -C ₁₂ cycloalkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, -CHO, -C (O) R 15a, -C (O) OR 15a, -C (O) SR ^15a , -C (O) NH ₂ , -C (O) N (R ^16a ) R ^15a , -C (O) NHC (O) R ^15a , -C (S) OR ^15a , -C ( S) SR ^15a , -C (S) NH ₂ , -C (S) N (R ^16a ) R ^15a , -OR ¹⁷ , -N (R ¹⁸ ) R ¹⁷ , -N = C (R ^17b ) R ^17a , -SR ¹⁵ , -S (O) ₂ R ^15a , -SN (R ²⁰ ) R ¹⁹ , -S (O) ₂ N (R ^16a ) R ^15a , phenyl or phenyl substituted by (Z) _p1 or by R ² is either form together with ^{R 1 = C (R 2a)} R 1a, or R ² forms a C ₂ -C ₇ alkylene chain together with R ^1, It represents that a 3-8 membered ring may be formed together with the nitrogen atom to be bonded. Is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, C ₁ -C ₆ alkoxy (C ₁ -C ₆₎ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ haloalkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, C ₁ -C ₆ haloalkoxycarbonyl group , C ₁ -C ₆ alkylaminocarbonyl group, C ₁ -C ₆ halo alkylaminocarbonyl group, a phenyl group, a phenyl group substituted by (Z) _p1, D32 group, optionally substituted with D34 group, oxo group or thioxo group May have been
R ^1a and R ^2a are each independently a hydrogen atom, C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₃ -C ₁₂ cycloalkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ haloalkenyl. , C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ ^{haloalkynyl, -OR 15, -SR 15, -NH} 2, -NHOH, -N (R 16) R 15, substituted by phenyl or (Z) _p1 Represents phenyl, or R ^1a and R ^2a together form a C ₄ -C ₅ alkylene chain or a C ₄ -C ₅ alkenylene chain to form a 5- to 6-membered ring with the carbon atoms to which it is attached. indicates that may be formed, this time the alkylene chain or alkenylene chain oxygen atom, may contain one to three sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ ~ C ₆ haloalkyl group, C ₁ -C ₆ alkoxy group, C ₁ -C ₆ haloalkoxy group, C ₁ -C ₆ alkylthio group, C ₁ -C ₆ Haroa Kiruchio group or may be optionally substituted by R ^17b group,
R ³ represents a halogen atom, cyano, optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ⁴ ( C ₃ -C ₈₎ cycloalkyl, substituted E1~E18, C ₃ ~C ₆ alkenyl, optionally substituted by R ⁴ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₆ alkynyl, optionally by R ⁴ been (C ₂ ~C ₆₎ ^{alkynyl, -OR 5, -S (O)} r R 5, -N (R 10) R 9, -N (R 10) R 9a, -CHO, -C (O) R ⁹ , -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -CH = NOR ¹¹ , -C (R ⁹ ) = NOR ¹¹ , -Si (R ^12a ) ( ^{R 12b) R 12, -P (} O) (oR 21) 2, represent phenyl, phenyl or D1~D38 substituted by (Z) _p1,
D1 to D38 each represent an aromatic heterocycle represented by the following structural formula;

Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~ C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, -OH, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkyl sulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ Haroaruki Sulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -NH _2, C ₁ ~C ₆ alkyl amino, di (C ₁ -C ₆ alkyl) amino, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C _{6 haloalkoxycarbonyl, -C (O) NH 2,} C 1 ~C 6 alkyl amino carbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, -C (S _{) NH 2, -S (O)} 2 NH 2, C 1 ~C 6 alkylaminosulfonyl, di (C ₁ -C ₆ alkyl) aminosulfonyl, phenyl optionally substituted by phenyl or halogen atom, p1, when p2, p3 or p4 represents an integer of 2 or more, each Z may be the same as or different from each other;
Further, when two Zs are adjacent to each other, the two adjacent Zs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O- , -OCH ₂ CH ₂ O-, -CH ₂ CH ₂ CH ₂ S-, -OCH ₂ CH ₂ S- or -CH = CH-CH = CH- may form a 5- or 6-membered ring together with the carbon atom, this time, the hydrogen atoms bonded to each carbon atom forming the ring is a halogen atom, a cyano group, a nitro group, C ₁ -C ₄ alkyl group may be optionally substituted by C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio group,
E1 to E18 each represent a saturated heterocyclic ring represented by the following structural formula;

R ⁴ is a halogen atom, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E1 to E18, —OH, —OR ⁵ , —SH, —S (O) _r R ⁵ , — N (R ⁷ ) R ⁶ , -N (R ⁷ ) C (O) R ^9a , -N (R ⁷ ) C (O) OR ^9a , -N (R ⁷ ) C (O) SR ^9a , -N ( R ⁷ ) C (S) OR ^9a , -N (R ⁷ ) C (S) SR ^9a , -N (R ⁷ ) S (O) ₂ R ^9a , -C (O) OR ⁹ , -C (O) N (R ¹⁰ ) R ⁹ , -Si (R ^12a ) (R ^12b ) R ¹² , phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ⁵ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ²⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ²⁴ (C ₃ ~C ₈ ) cycloalkyl, E2~E5, E11~E13, E14, E17 , C 2 ~C 6 alkenyl, optionally substituted by R ²⁴ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₈ cycloalkenyl, C ₃ -C ₈ halocycloalkyl cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ²⁴ (C ₃ ~C ₆₎ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, ( Z) represents phenyl, D1, D2, D4-D6, D8-D10, D12-D19, D21, D23, D25, D27, D30-D37 or D38 substituted by _p1 ,
R ⁶ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, -C (O) R 9, -C (O) OR 9, -C (O) SR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C ( S) N (R ¹⁰ ) R ⁹ , -C (O) C (O) R ⁹ , -C (O) C (O) OR ⁹ , -OH, -S (O) ₂ R ⁹ , -S (O ) ₂ N (R ¹⁰ ) R ⁹ , -P (O) (OR ²¹ ) ₂ or -P (S) (OR ²¹ ) ₂
R ⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, C ₁ -C ₆ alkylcarbonyl, or represents C ₁ -C ₆ haloalkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, or , R ⁷ together with R ⁶ to form a C ₂ -C ₆ alkylene chain, it is possible to form a 3- to 7-membered ring with the nitrogen atom to which R ⁷ is bonded, oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, may be optionally substituted by oxo or thioxo group,
R ⁸ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ alkenyl, phenyl or phenyl substituted by (Z) _p1 ;
R ⁹ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1-E18, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl or C ₂ -C ₆ haloalkynyl,
R ^9a represents phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ¹⁰ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, or represents C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or, R ¹⁰ is R by forming a C ₂ -C ₆ alkylene chain together with ^9, it indicates that may form a 3- to 7-membered ring together with the nitrogen atom to which they are attached this case the alkylene chain an oxygen atom, a sulfur atom or nitrogen atoms may be one comprise, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl Optionally substituted by a group,
R ¹¹ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ represents alkenyl, C ₃ -C ₆ haloalkenyl, a C ₃ -C ₆ alkynyl or C ₃ -C ₆ haloalkynyl,
R ¹² represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _p1 ;
R ^12a and R ^12b each independently represent C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkoxy;
R ¹³ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxycarbonyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxycarbonyl (C ₁ -C ₄₎ alkyl, phenyl (C ₁ -C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ -C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ ~ C ₆ represents alkynyl, C ₃ -C ₆ haloalkynyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenyl substituted by phenyl or (Z) _p1,
Further, when Z is present at the adjacent position to R ¹³ is, -CH ₂ and adjacent R ¹³ and _{Z CH 2 CH 2 CH 2 -} , -CH = CH-CH = CH-, -N = CH- By forming CH = CH-, -CH = N-CH = CH-, -CH = CH-N = CH- or -CH = CH-CH = N-, a 6-membered ring is formed together with the atoms to which each is bonded. it may be formed, this time, the hydrogen atoms bonded to each carbon atom forming the ring may be optionally substituted by halogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl group ,
R ¹⁴ is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, hydroxy (C ₃ -C ₆ ) cycloalkyl, C ₁ -C ₄ alkoxy (C ₃ -C ₆₎ cycloalkyl, C ₅ -C ₆ ^{cycloalkenyl, E1~E18, -OR 25, -N (} R 26) R 25, -SH, -S (O) r R 27, -CHO, -C (O) R ²⁸ , -C (R ³¹ ) = NOH, -C (R ³¹ ) = NOR ³⁰ , M3, M4, M11, M12, -C (O) OH, -C (O) OR ²⁸ , -C (O) SR ²⁸ , -C (O) NH ₂ , -C (O) N (R ²⁹ ) R ²⁸ , -C (O) N (R ²⁹ ) OR ²⁸ , -C (O) N (R ²⁹ ) N (R ^28a ) R ²⁸ , -C (S) OR ²⁸ , -C (S) SR ²⁸ , -C (S) NH ₂ , -C (S) N (R ²⁹ ) R ²⁸ , -C (= NR ³¹ ) OR ³⁰ , -C (= NR ³¹ ) SR ³⁰ , -C (= NR ³¹ ) N (R ²⁹ ) R ³⁰ , -C (= NOR ³¹ ) NH ₂ , -C (= NOR ³¹ ) N (R ²⁹ ) R ^{30, M1, M2, M5~M10,} M13~M18, -C (O) C (O) OR 28, -SO 2 OH, -SO 2 NH 2, -SO 2 N (R 29) R 28, -Si (R ^12a ) (R ^12b ) R ¹² , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, phenyl substituted by (Z) _p1, naphthoquinone It represents Le or D1～D38,
M1 to M18 each represents a partially saturated heterocyclic ring represented by the following structural formula,

R ^14a is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, C ₅ -C ₆ cycloalkenyl, -OR ²⁵ , -N (R ²⁶ ) R ²⁵ , -S (O) _r R ²⁷ ,- CHO, -C (O) R ²⁸ , -C (R ³¹ ) = NOH, -C (R ³¹ ) = NOR ³⁰ , -C (O) OH, -C (O) OR ²⁸ , -C (O) SR _{^{28, -C (O) NH 2}} , -C (O) N (R 29) R 28, -C (S) OR 28, -C (S) SR 28, -C (S) NH 2, -C ( S) N (R ²⁹ ) R ²⁸ , -C (O) C (O) OR ²⁸ , -C (= NR ³¹ ) OR ³⁰ , -C (= NR ³¹ ) SR ³⁰ , -C (= NR ³¹ ) N (R ²⁹ ) R ³⁰ , -C (= NOR ³¹ ) NH ₂ , -C (= NOR ³¹ ) N (R ²⁹ ) R ³⁰ , M1, M3, M5, M5, M9, M11, M13, M15, M17, -SO ₂ OH, -SO ₂ NH ₂ , -SO ₂ N (R ²⁹ ) R ²⁸ , -Si (R ^12a ) (R ^12b ) R ¹² , -P (O) (OR ²¹ ) ₂ , -P (S ) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, (Z) _p1 substituted with phenyl, naphthyl or D1-D38,
R ¹⁵ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1-E18, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl, represents phenyl, phenyl or D1~D38 substituted by (Z) _p1,
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfinyl (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfonyl (C _{1 ~C 4)} alkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C _{8 halocycloalkyl, E3~E5, E11~E13, C 2 ~C} 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl represents C ₁ -C ₆ alkoxycarbonyl, phenyl, phenyl or D1~D38 substituted by (Z) _p1,
R ¹⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, or represents C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or, R ¹⁶ is R ^{by 15} together to form a C ₂ -C ₆ alkylene chain, represents that may form a 3- to 7-membered ring together with the atoms connecting, this time the alkylene chain an oxygen atom, a sulfur atom or nitrogen atoms may be one comprise, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl group Optionally substituted by
R ^16a represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ¹⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E 3- E5, E11~E13, C ₃ ~C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, -C (O) R 28, -C ( O) OR ²⁸ , -C (O) SR ²⁸ , -C (O) NH ₂ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) OR ²⁸ , -C (S) SR ²⁸ , _{-C (S) NH 2, -C} (S) N (R 29) R 28, -S (O) 2 R 28, -S (O) 2 NH 2, -S (O) 2 N (R 29) R ²⁸ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 , D1-D6, D8-D12, D14-D19, D23 , D25, D30 to D37 or D38,
R ^17a is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl , C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ ~C ₄₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, substituted by (Z) _p1 phenyl (C ₁ -C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, E1～E18, phenyl (C ₂ -C ₄₎ alkenyl, di (C ₁ -C ₆ alkyl) amino, phenyl, (Z) _p1 Represents phenyl or D1-D38 substituted by
R ^17b represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio or di (C ₁ -C ₆ alkyl) amino, or R ^17a and R ^17b Together form a C ₃ -C ₅ alkylene chain to form a 4-6 membered ring with the carbon atoms to which it is bonded, wherein the alkylene chain is an oxygen atom, sulfur atom or one nitrogen atom may contain, and halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl group Optionally substituted by
R ¹⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C _{1 ~C 4)} alkyl, cyano (C _{1 ~C 6)} alkyl, C ₁ -C ₄ alkoxycarbonyl (C _{1 ~C 4)} alkyl, phenyl (C _{1 ~C 4)} alkyl , (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, - ^{CHO, -C (O) R 15} , -C (O) oR 15, -C (O) SR 15, -C (S) oR 15, -C (S) SR 15, C 1 ~C 6 alkylsulfonyl or or represents C ₁ -C ₆ haloalkylsulfonyl, or together with R ¹⁸ is R ¹⁷ By now it forms a C ₄ -C ₅ alkylene chain, represents that may form a 5- or 6-membered ring together with the nitrogen atom to which they are attached this case the alkylene chain an oxygen atom, a sulfur atom or a nitrogen atom 1 to C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy (C ₁ -C ₆ ) alkyl group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or C ₁ -C ₆ alkoxy Optionally substituted by a carbonyl group,
R ¹⁹ is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, C ₁ -C ₁₂ alkylcarbonyl, C ₁ -C ₁₂ alkoxycarbonyl, -C (O) ON = C (CH 3) SCH 3, -C (O) ON = C (SCH ₃ ) C (O) N (CH ₃ ) ₂ represents phenyl or phenyl substituted by (Z) _p1 ,
R ²⁰ is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, phenyl or (Z) or represents phenyl which is substituted by _p1, or, R ²⁰ together with R ¹⁹ C ₄ ~C ₇ alkylene By forming a chain, it represents that a 5- to 8-membered ring may be formed together with the nitrogen atom to be bonded, and at this time, the alkylene chain may contain one oxygen atom or sulfur atom, and C ₁ -C may be optionally substituted by ₄ alkyl or C ₁ -C ₄ alkoxy group,
R ²¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ²² is a halogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ -C ₆ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylamino, di (C ₁ -C ₄ alkyl) amino, C ₁ ~ C ₆ alkoxycarbonyl, represents phenyl substituted by phenyl or _{(Z) p1, q1, q2} , q3, q4, when q5 or q6 is an integer of 2 or more, each R ²² is also the same as each other , or may be the different from each other, further, when two R ²² are substituted on the same carbon atom, the two R ²² oxo together, thioxo, imino, C ₁ -C ₆ alkyl indicates that the imino, may form a C ₁ -C ₆ alkoxyimino or C ₁ -C ₆ alkylidene,
R ²³ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C optionally substituted by R ³² ₆ haloalkenyl, C ₃ -C ₆ alkynyl, -OH, benzyloxy, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR ³⁴ , -C (O) N (R ³⁴ ) R ³³ , -C (S) NHR ³⁴ , -C (S) N (R ³⁴ ) R ³³ , -S (O) ₂ R ³³ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, (Z) represents phenyl substituted by _p1 or D3,
R ²⁴ is halogen atom, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1~E18, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, C ₁ -C ₆ alkylamino, di (C ₁ -C ₆ alkyl) amino, -CHO, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ alkylaminocarbonyl, di (C ₁ -C ₆ alkyl) amino Represents carbonyl, phenyl, phenyl substituted by (Z) _p1 or D1-D38;
R ²⁵ is a hydrogen atom, C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³² (C ₃ -C ₈₎ cycloalkyl, E2~E5, E11~E14, E17, C 3 ~C 8 alkenyl, optionally substituted by R ³² (C ₃ ~C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, R ³² optionally substituted by (C ₃ ~C ₈₎ alkynyl, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR 34, -C (O) N (R ³⁴ ) R ³³ , -C (S) R ³³ , -C (S) OR ³³ , -C (S) SR ³³ , -C (S) NHR ³⁴ , -C (S) N (R ³⁴ ) R ³³ , -C (O) C (O) R ³³ , -C (O) C (O) OR ³³ , -S (O) ₂ R ³³ , -S (O) ₂ N (R ^{34) R 33, -Si (R} 12a) (R 12b) R 12, -P (O) (OR 21) 2, -P (S) (OR 21) 2, phenyl, substituted by (Z) _p1 Phenyl, D1, D2, D4 to D6, D8 to D10, D12 to D19, D21, D23, D25, D27, D30 to D37 or D38,
R ²⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _{p 1} or R ²⁶ is By forming a C ₂ -C ₅ alkylene chain together with R ²⁵ , this means that a 3- to 6-membered ring may be formed together with the nitrogen atom to be bonded, and this alkylene chain is an oxygen atom, sulfur atom or a nitrogen atom may be one comprise a, and halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, C ₁ -C ₆ alkoxy group, a phenyl group, substituted by (Z) _p1 Optionally substituted by a phenyl, oxo or thioxo group,
R ²⁷ is optionally substituted by C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³² (C ₃ ~C ₈ ) cycloalkyl, E2~E5, E11~E14, E17, C 3 ~C 8 alkenyl, optionally substituted by R ³² (C ₃ -C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, optionally by R ³² substituted (C ₃ ~C ₈₎ alkynyl, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR 34, -C ( O) N (R ³⁴ ) R ³³ , -C (S) R ³³ , -C (S) OR ³³ , -C (S) SR ³³ , -C (S) NHR ³⁴ , -C (S) N (R ^{34) R 33, -C (O} ) C (O) R 33, -C (O) C (O) OR 33, -SH, C 1 ~C 6 alkylthio, C ₁ -C ₆ haloalkylthio, phenylthio, ( phenylthio substituted by _{Z) p1, -P (O)} (OR 21) 2, -P (S) (OR 21) 2, phenyl, phenyl substituted by _{(Z) p1, D9, D10} , D12, D14 ~ Represents D17, D32 or D34,
R ²⁸ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ³² (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³² (C ₃ ~C ₈ ) cycloalkyl, C ₂ -C ₆ alkenyl (C ₃ -C ₈₎ cycloalkyl, C ₂ -C ₆ haloalkenyl (C ₃ -C ₈₎ cycloalkyl, E1~E18, C ₂ ~C ₈ alkenyl, R ³² substituted phenyl which optionally substituted (C ₂ ~C ₈₎ alkenyl, C ₂ -C ₈ alkynyl, optionally substituted by R ³² (C ₂ ~C ₈₎ alkynyl, phenyl, by (Z) _p1 by Or D1-D38,
R ^28a represents a hydrogen atom or a C ₁ -C ₆ alkyl,
R ²⁹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C Represents ₆ alkynyl, C ₃ -C ₆ haloalkynyl, phenyl or phenyl substituted by (Z) _{p 1} , or R ²⁹ together with R ²⁸ forms a C ₂ -C ₅ alkylene chain Represents that a 3- to 6-membered ring may be formed together with the nitrogen atom to be bonded, in which case the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, optionally by phenyl substituted by phenyl or (Z) _p1 May be replaced,
R ³⁰ is C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ -C ₈ ) alkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ alkenyl, optionally substituted by R ³² and (C ₃ ~C ₈₎ alkenyl, optionally substituted by C ₃ -C ₈ alkynyl, or R ³² (C ₃ ~C ₈₎ alkynyl,
R ³¹ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylsulfonyl (C _{1 ~C 4)} alkyl, C ₁ -C ₆ haloalkylsulfonyl (C _{1 ~C 4)} alkyl, phenyl (C _{1 ~C 4)} alkyl, phenyl substituted by (Z) _p1 (C ₁ ~C ₄₎ represents alkyl, C ₃ -C ₆ cycloalkyl, phenyl substituted by phenyl or (Z) _p1,
R ³² is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E3, E4, E6, E7 , E9, E11, E12, E14, E15, E17, -OH , -OR ³³ , -OC (O) R ³³ , -OC (O) OR ³³ , -OC (O) NHR ³⁴ , -OC (O) N (R ³⁴ ) R ³³ , -OC (S) NHR ³⁴ , -OC (S) N (R ³⁴ ) R ³³ , -SH, -S (O) _r R ³³ , -SC (O) R ³³ , -SC (O) OR ³³ , -SC (O) NHR ³⁴ ,- SC (O) N (R ³⁴ ) R ³³ , -SC (S) NHR ³⁴ , -SC (S) N (R ³⁴ ) R ³³ , -NHR ³⁴ , -N (R ³⁴ ) R ³³ , -N (R ³⁴ ) CHO, -N (R ³⁴ ) C (O) R ³³ , -N (R ³⁴ ) C (O) OR ³³ , -N (R ³⁴ ) C (O) NHR ³⁴ , -N (R ³⁴ ) C (O) N (R ³⁴ ) R ³³ , -N (R ³⁴ ) C (S) NHR ³⁴ , -N (R ³⁴ ) C (S) N (R ³⁴ ) R ³³ , -CHO, -C (O) R ³³ , -C (O) OH, -C (O) OR ³³ , -C (O) SR ³³ , -C (O) NHR ³⁴ , -C (O) N (R ³⁴ ) R ³³ , -C ( O) C (O) OR ³³ , -Si (R ^12a ) (R ^12b ) R ¹² , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ³³ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocyclo. alkyl, C ₂ -C ₆ alkenyl (C ₃ ~C ₈₎ cycloalkyl, C ₂ -C ₆ haloalkenyl (C ₃ ~C ₈₎ cycloalkyl, E3, E4, E11, E12 , C 2 ~C 8 alkenyl, C ₂ -C ₈ haloalkenyl, C ₃ -C ₈ cycloalkenyl, C ₃ -C ₈ halocycloalkyl cycloalkenyl, C ₂ -C ₈ alkynyl, C ₂ -C ₈ haloalkynyl, substituted phenyl, the (Z) _p1 Represents phenyl or D1-D38,
R ³⁴ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkylcarbonyl , C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenoxycarbonyl, phenoxycarbonyl substituted by (Z) _p1, phenylcarbonyl, substituted by (Z) _p1 phenylcarbonyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, phenyl, phenyl substituted by _{(Z) p1, D1, D2} , D4~D6, D8~D10, D12~D19, D21, D21, D23, D25, D27, or represents D30~D37 or D38, or, R ³⁴ is 3-6 by forming a C ₂ -C ₅ alkylene chain together with R ^33, together with the nitrogen atom bonded Represents that a member ring may be formed. It can the alkylene chain is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkyl carbonyl group, C ₁ -C ₆ alkoxycarbonyl group, it may be optionally substituted by a phenyl group substituted by a phenyl group or (Z) _p1,
R ³⁵ represents cyano, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, E3, E4, E11, E12 , C 1 ~C 4 alkoxy, C ₁ -C ₄ haloalkoxy, phenoxy, (Z ) _p1 phenoxy substituted by, C ₁ -C ₄ alkylthio, C ₁ -C ₄ haloalkylthio, C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ haloalkylsulfonyl, phenylthio, phenylthio substituted by (Z) _p1 , -N (R ³⁷ ) R ³⁶ , C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, tri (C ₁ -C ₄ alkyl) silyl, phenyl, phenyl, naphthyl or D1~D38 substituted by (Z) _p1,
R ³⁶ is phenyl substituted by a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenylcarbonyl or (Z) _p1 Represents carbonyl,
R ³⁷ represents a hydrogen atom or C ₁ -C ₄ alkyl,
m represents an integer of 0 to 5;
n represents an integer of 0 to 4,
p represents an integer of 0 to 4,
p1 represents an integer of 1 to 5,
p2 represents an integer of 0 to 4,
p3 represents an integer of 0 to 3,
p4 represents an integer of 0 to 2,
p5 represents an integer of 0 or 1,
q1 represents an integer of 0 to 3,
q2 represents an integer of 0 to 5,
q3 represents an integer of 0 to 7,
q4 represents an integer of 0 to 9,
q5 represents an integer of 0 to 6,
q6 represents an integer of 0 to 4,
r represents an integer of 0 to 2;
t represents an integer of 0 or 1. ]
Or a salt thereof.

[2] A ¹ represents a carbon atom or a nitrogen atom,
A ² and A ³ represent a carbon atom,
G ¹ represents a benzene ring,
G ² represents a nitrogen-containing aromatic 5-membered ring represented by any of G ² -1 to G ² -9,

X is a halogen atom, nitro, -SF _5, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₆₎ haloalkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₆ ) Haloalkyl, C ₃ -C ₈ halocycloalkyl, —OR ⁵ , —OSO ₂ R ⁵ or —S (O) _r R ^5, and when m represents 2 or 3, each X is identical to each other. Or they may be different from each other,
Y is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, optionally substituted by C ₁ -C _{6 ^{haloalkyl, R 4 (C 1 ~C 4}} ) alkyl, C ₃ -C ₆ alkynyl, -OR ⁵ , —SR ⁵ , —NH ₂ , —N (R ⁷ ) R ⁶ or —C (S) NH _2, and when n represents ₂ , each Y may be the same as or different from each other You may,
Z ^a is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -C (O) N (R 2) R 1 or ^{-C (S) N (R 2} ) represents R ^1, when p2~p4 represents an integer of 2 or more, each Z ^a are each They may be the same or different from each other,
R ¹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl, C ₃ -C ₆ cycloalkyl, E 3, E 11, C ₃ -C ₆ alkenyl optionally substituted by R ¹⁴ , C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ ^{alkynyl, -C (R 16) = NOR} 15, -C (O) OR 15, -C (O) NH 2, -C (O) N (R 16 ) R ¹⁵ , -C (O) NHC (O) R ¹⁵ , -C (O) N (R ¹⁶ ) C (O) OR ¹⁵ , -C (S) NH ₂ , -C (S) N (R ¹⁶ ) R ¹⁵ , -N (R ¹⁸ ) R ¹⁷ , (Z) represents phenyl, D5-D8, D10, D17, D32-D34 or D35 substituted by _p1 ,
R ² is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ^14a , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ represents an ^{alkynyl, -C (O) R 15a,} -C a (O) oR ^15a or C ₁ -C ₆ haloalkylthio,
R ³ represents C ₁ -C ₆ haloalkyl or C ₃ -C ₈ halocycloalkyl,
Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ represent alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, -C (O) NH _2, a -C (S) NH ₂ or _{-S (O) 2 NH 2,} p1, when p2 and p3 represent an integer of 2 or more, each Z may be the same as or different from each other;
R ⁴ represents —OH, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio,
R ⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₃ haloalkoxy (C ₁ -C ₃ ) haloalkyl,
R ⁶ is, C ₁ -C ₆ alkyl, -CHO, C ₁ ~C ₆ alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ alkylthiocarbonyl, C ₁ -C ₆ alkoxythiocarbonyl, C ₁ -C ₆ alkyl dithio carbonyl, represents C ₁ -C ₆ alkylsulfonyl or C ₁ -C ₆ haloalkylsulfonyl,
R ⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹³ represents C ₁ -C ₆ alkyl,
R ¹⁴ is halogen atom, cyano, C ₃ -C ₆ cycloalkyl, E3, E6, -OH, -OR 25, C 1 ~C 6 alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ alkylsulfonyl , -N (R ²⁶ ) R ²⁵ , C ₁ -C ₆ alkylcarbonyl, -C (R ³¹ ) = NOR ³⁰ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) NH ₂ , phenyl (Z) represents phenyl substituted by _p1 , D1, D5, D7, D8, D10, D13, D16, D17, D22, D32 or D34,
R ^14a represents a halogen atom, cyano or -OR ²⁵ ,
R ¹⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³² or C ₂ -C ₆ alkenyl,
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, C ₁ -C ₆ Represents alkoxycarbonyl, phenyl, phenyl substituted by (Z) _p1 or D32;
R ¹⁶ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹⁷ represents C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, phenyl substituted by (Z) _p1 , D32 or D34,
R ¹⁸ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl,
R ²² represents C ₁ -C ₆ alkyl;
R ²⁵ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, -C (O) R ³³ or -C (O) OR ³³ ,
R ²⁶ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ²⁸ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ²⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ³⁰ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₁ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl;
R ³¹ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ³² represents C ₃ -C ₆ cycloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkoxycarbonyl, phenyl substituted by (Z) _p1 or D32,
R ³³ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₆ cycloalkyl or phenyl;
m represents an integer of 1 to 3,
n represents an integer of 0 or 1,
p1 represents an integer of 1 to 3,
p2 and p3 represent an integer of 0 to 2,
q2 represents an integer of 0 to 3,
q3 and q4 represent an integer of 0 to 2,
t is a substituted isoxazoline compound or a salt thereof according to the above [1], in which t represents 0;

[3] G ² represents G ² -1, G ² -2, G ² -3, G ² -4, G ² -5, G ² -7 or G ² -8,
X is a halogen atom, nitro, cyano, C ₁ -C ₆ represents alkyl, C ₁ -C ₆ haloalkyl, the -OR ⁵ or -S (O) _{r R} ^5, when m is 2 or 3, each of the X may be the same as or different from each other;
Y is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -OR ^5, -SR ^5, an -NH ₂ or -N (R ⁷⁾ R ^6,
Z ^a is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ ~ C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -C (O) N (R 2) R 1 or -C (S) N (R ² ) R ¹ and when p represents an integer of 2 or more, each Z ^a may be the same as or different from each other,
R ¹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ¹⁴ , C ₃ -C ₆ cycloalkyl, E3, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ ^{alkynyl, -C (R 16) = NOR} 15, -C (O) OR 15, -C (O) NH 2, -C (O) N (R 16) R ¹⁵ , -C (O) NHC (O) R ¹⁵ , -C (O) N (R ¹⁶ ) C (O) OR ¹⁵ , -N (R ¹⁸ ) R ¹⁷ , (Z) phenyl substituted by _p1 , D6-D8, D10, D32, D34 or D35,
R ² is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₄ ) alkyl, C ₃ -C ₆ alkynyl, optionally substituted by R ^14a , -C (O) R ^15a , -C (O ) represents oR ^15a or C ₁ -C ₆ haloalkylthio,
R ³ represents C ₁ -C ₆ haloalkyl,
Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, a C ₁ -C ₆ alkoxy or C ₁ -C ₆ alkylsulfonyloxy, p1 indicates an integer of 2 or more Each Z may be the same as or different from each other,
R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ⁶ represents C ₁ -C ₆ alkyl, —CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
R ¹⁴ is halogen atom, cyano, C ₃ -C _{6 cycloalkyl, E3, E6, C 1 ~C} 6 alkoxy, C ₁ -C ₆ ^{haloalkoxy, -NHC (O) OR 33,} -C (R 31) = NOR ³⁰ , -C (O) N (R ²⁹ ) R ²⁸ , phenyl, (Z) represents phenyl, D1, D8, D10, D13, D16, D22, D32 or D34 substituted by _p1 ,
R ^14a represents cyano or -OR ²⁵
R ¹⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or (C ₁ -C ₄ ) alkyl optionally substituted by R ³² ;
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ represents alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl or C ₂ -C ₆ alkenyl,
R ¹⁷ represents C ₁ -C ₆ haloalkyl, phenyl, phenyl substituted by (Z) _p1 , D32 or D34,
R ²⁵ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or -C (O) R ³³ ;
R ²⁸ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ³⁰ represents C ₁ -C ₄ alkyl,
R ³² represents phenyl substituted by (Z) _p1 ,
R ³³ represents C ₁ -C ₄ alkyl,
p2, p3 and p4 represent an integer of 0 or 1,
q2 represents an integer of 0 or 1,
q3 is the substituted isoxazoline compound or a salt thereof according to the above [2], wherein 0 is 0.

[4] A ¹ represents a carbon atom,
G ² represents G ² -2, G ² -5 or G ² -8,
X is a halogen atom or a C ₁ -C ₆ haloalkyl, when m is 2 or 3, each X may be the or different from each other the same as each other,
Y represents a halogen atom, nitro, a C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
Z ^a represents -C (O) N (R ² ) R ¹
R ¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ² represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ³ represents -CF ₃ or -CF ₂ Cl,
p3 represents 1,
The substituted isoxazoline compound or a salt thereof according to the above [3], wherein p4 and p5 represent 0.

  [5] General formula (2):

[Wherein A ¹ represents a carbon atom or a nitrogen atom,
J represents a hydrogen atom or a halogen atom,
G ² is a nitrogen-containing aromatic 5-membered ring G ² -1, G ² -2, G ² -3, G ² -4, G ² -5, G ² -7, or Represents G ² -8,

Y represents a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, the -OR ⁵ or -N (R ⁷⁾ R ^6,
Z ^a is a halogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -C (O) N (R 2) R 1 or ^{-C (S) N (R 2} ) represents R ^1, when p represents an integer of 2 or more, each Z ^a may be the even or different from each other the same as each other,
R ¹ is hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ¹⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₆ cycloalkyl, E3, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ ^{alkynyl, -C (O) OR 15,} -C (O) NH 2, -C (O) N (R 16) R 15, -C (O) NHC (O ) R ¹⁵ , -C (O) N (R ¹⁶ ) C (O) OR ¹⁵ , (Z) represents phenyl, D6-D8, D10, D32, D34 or D35 substituted by _p1 ,
R ² is a hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ^14a (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ alkynyl, -C (O) R ^15a or -C (O Represents OR ^15a
R ³ represents C ₁ -C ₆ haloalkyl,
R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ⁶ represents -CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
R ⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹⁴ is halogen atom, cyano, C ₃ -C _{6 cycloalkyl, E3, E6, C 1 ~C} 6 alkoxy, C ₁ -C ₆ ^{haloalkoxy, -NHC (O) OR 33,} -C (O) N (R ²⁹⁾ R ^28, represents phenyl, (Z) phenyl substituted by _{p1, D1, D8, D10,} D13, D16, D22, D32 or D34,
D1, D6 to D8, D10, D13, D16, D22, D32, D34 and D35 each represent an aromatic heterocycle represented by the following structural formula,

Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, a C ₁ -C ₆ alkoxy or C ₁ -C ₆ alkylsulfonyloxy, p1 indicates an integer of 2 or more Each Z may be the same as or different from each other,
R ¹³ represents C ₁ -C ₆ alkyl,
E3 and E6 each represent a saturated heterocyclic ring represented by the following structural formula;

R ^14a represents cyano or -OR ²⁵
R ¹⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or (C ₁ -C ₄ ) alkyl optionally substituted by R ³² ;
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfonyl (C _{1 ~C 4)} represents alkyl, a C ₃ -C ₆ cycloalkyl or C ₂ -C ₆ alkenyl,
R ²² represents C ₁ -C ₆ alkyl;
R ²⁵ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or -C (O) R ³³ ;
R ²⁸ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ³² represents phenyl substituted by (Z) _p1 ,
R ³³ represents C ₁ -C ₄ alkyl,
n represents an integer of 0 or 1,
p1 represents an integer of 1 to 3,
p2, p3, p4 and p5 represent an integer of 0 or 1,
q2 represents an integer of 0 or 1,
q3 represents 0,
t represents 0. ]
A 4-substituted benzaldoxime compound represented by the formula:

[6] A ¹ represents a carbon atom,
G ² represents G ² -2, G ² -5 or G ² -8,
Y represents a halogen atom, nitro, a C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
Z ^a represents -C (O) N (R ² ) R ¹
R ¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ² represents a hydrogen atom or C ₁ -C ₆ alkyl,
p3 represents 1,
The 4-substituted benzaldoxime compound or a salt thereof according to the above [5], wherein p4 and p5 represent 0.

  [7] A pest control agent containing, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [4] above.

  [8] An agrochemical containing, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [4] above.

  [9] An internal or ectoparasite control agent for mammals or birds containing one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [4] as active ingredients.

  [10] An insecticide or acaricide containing, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof described in [1] to [4] above.

  The active compounds used as pest control agents in the present invention are the compounds represented by the above [1] to [4], and the compounds represented by the above [5] to [6] are used for the production of these active compounds. It is a novel production intermediate used.

  The compound of the present invention has excellent insecticidal / miticidal activity against many agricultural pests, spider mites, mammals or birds' internal or ectoparasites, and has acquired resistance against existing insecticides. Even against this, it exhibits a sufficient control effect. Furthermore, it has little adverse effect on mammals, fish and beneficial insects, has low persistence, and has a light environmental impact.

  Therefore, the present invention can provide a useful novel pest control agent.

  The compounds encompassed by the present invention may have geometrical isomers of E-form and Z-form depending on the type of substituent, but the present invention is not limited to these E-form, Z-form or E-form. And a mixture containing the Z-form in an arbitrary ratio. In addition, the compounds included in the present invention include optically active substances resulting from the presence of one or more asymmetric carbon atoms, but the present invention includes all optically active substances or racemates.

  Among the compounds included in the present invention, those that can be converted into acid addition salts according to a conventional method include, for example, hydrohalic acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, and the like. Salt of inorganic acid such as salt, nitric acid, sulfuric acid, phosphoric acid, chloric acid, perchloric acid, salt of sulfonic acid such as methanesulfonic acid, ethanesulfonic acid, trifluoromethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, Salts of carboxylic acids such as formic acid, acetic acid, propionic acid, trifluoroacetic acid, fumaric acid, tartaric acid, succinic acid, maleic acid, malic acid, succinic acid, benzoic acid, mandelic acid, ascorbic acid, lactic acid, gluconic acid, citric acid, etc. A salt of an amino acid such as glutamic acid or aspartic acid can be used.

  Alternatively, among the compounds included in the present invention, those that can be converted into a metal salt according to a conventional method include, for example, alkali metal salts such as lithium, sodium, and potassium, and alkaline earth metals such as calcium, barium, and magnesium. It can be a salt or a salt of aluminum.

  Next, specific examples of each substituent shown in the present specification are shown below. Here, n- represents normal, i- represents iso, s- represents secondary, and t- represents tertiary, and Ph represents phenyl.

  As a halogen atom in this invention compound, a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom are mentioned. In the present specification, the notation “halo” also represents these halogen atoms.

The notation of C _{a to} C _b alkyl in the present specification represents a linear or branched hydrocarbon group having a carbon number of _a to _b , for example, methyl group, ethyl group, n-propyl group, i-propyl group, n-butyl group, i-butyl group, s-butyl group, t-butyl group, n-pentyl group, 1-methylbutyl group, 2-methylbutyl group, 3-methylbutyl group, 1-ethylpropyl group 1,1-dimethylpropyl group, 1,2-dimethylpropyl group, 2,2-dimethylpropyl group, n-hexyl group, 1-methylpentyl group, 2-methylpentyl group, 1,1-dimethylbutyl group, Specific examples include 1,3-dimethylbutyl group, heptyl group, octyl group, nonyl group, decyl group, undecyl group, dodecyl group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b haloalkyl is represented by a linear or branched chain consisting of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. Represents a hydrocarbon group, and when substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, fluoromethyl group, chloromethyl group, bromomethyl group, iodomethyl group, difluoromethyl group, chlorofluoromethyl group, dichloromethyl group, bromofluoromethyl group, trifluoromethyl group, chlorodifluoromethyl group, dichlorofluoromethyl group, trichloromethyl Group, bromodifluoromethyl group, bromochlorofluoromethyl group, difluoroiodomethyl group, 2-fluoroethyl group, 2-chloroethyl group, 2-bromoethyl group, 2,2-difluoroethyl group, 2-chloro-2-fluoroethyl Group, 2,2-dichloroethyl group, 2-bromo-2-fluoroethyl group, 2,2,2-trifluoroethyl group, 2-chloro-2,2-difluoroethyl group, 2,2-dichloro-2 -Fluoroethyl group, 2,2,2-trichloroethyl group, 2-bromo-2,2-difluoroethyl group, 1,1,2,2-tetrafluoroethyl group, pentaf Oroethyl group, 1-chloro-1,2,2,2-tetrafluoroethyl group, 2-chloro-1,1,2,2-tetrafluoroethyl group, 1,2-dichloro-1,2,2-tri Fluoroethyl group, 1-bromo-1,2,2,2-tetrafluoroethyl group, 2-bromo-1,1,2,2-tetrafluoroethyl group, 2-fluoropropyl group, 2-chloropropyl group, 2,3-dichloropropyl group, 3,3,3-trifluoropropyl group, 3-bromo-3,3-difluoropropyl group, 2,2,3,3-tetrafluoropropyl group, 2,2,3, 3,3-pentafluoropropyl group, 1,1,2,3,3,3-hexafluoropropyl group, heptafluoropropyl group, 2,3-dichloro-1,1,2,3,3-pentafluoropropyl group Group, 2-fluoro-1-methylethyl group, 2-chloro-1-methylethyl group, 2-bromo-1-methylethyl group, 2,2,2-trifluoro-1- (trifluoromethyl) ethyl group 1,2,2,2-tetrafluoro-1- (trifluoromethyl) ethyl , Nonafluorobutyl group, etc. As a specific example, it may be selected from the range of the specified number of carbon atoms.

In the present specification, C _{a to} C _b cycloalkyl represents a cyclic hydrocarbon group having _a to _b carbon atoms, and forms a monocyclic or complex ring structure having 3 to 6 members. I can do it. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms. For example, cyclopropyl group, 1-methylcyclopropyl group, 2-methylcyclopropyl group, 2,2-dimethylcyclopropyl group, 2,2,3,3-tetramethylcyclopropyl group, cyclobutyl group, cyclopentyl group, cyclohexyl group Bicyclo [2.2.1] heptan-2-yl group and the like are listed as specific examples, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b halocycloalkyl represents a cyclic hydrocarbon group composed of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And can form monocyclic or complex ring structures from 3 to 6-membered rings. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the substitution with a halogen atom may be a ring structure part, a side chain part, They may be both, and when they are substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, 2-fluorocyclopropyl group, 2-chlorocyclopropyl group, 2,2-difluorocyclopropyl group, 2,2-dichlorocyclopropyl group, 2,2-dibromocyclopropyl group, 2,2-difluoro-1- Specific examples include methylcyclopropyl, 2,2-dichloro-1-methylcyclopropyl, 2,2,3,3-tetrafluorocyclobutyl, 2-chloro-2,3,3-trifluorocyclobutyl, etc. As an example, each selected range of carbon atoms is selected.

In the present specification, C _{a to} C _b alkenyl is a linear or branched chain composed of _a to _b carbon atoms and has one or more double bonds in the molecule. Represents a saturated hydrocarbon group, for example, vinyl group, 1-propenyl group, 2-propenyl group, 1-methylethenyl group, 2-butenyl group, 1-methyl-2-propenyl group, 2-methyl-2-propenyl group, 2 -Pentenyl group, 2-methyl-2-butenyl group, 3-methyl-2-butenyl group, 2-ethyl-2-propenyl group, 1,1-dimethyl-2-propenyl group, 2-hexenyl group, 2-methyl Specific examples include 2-pentenyl group, 2,4-dimethyl-2,6-heptadienyl group, 3,7-dimethyl-2,6-octadienyl group, etc. Is done.

In the present specification, C _a -C _b haloalkenyl is a linear or branched chain consisting of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And an unsaturated hydrocarbon group having one or more double bonds in the molecule. At this time, when substituted with two or more halogen atoms, the halogen atoms may be the same as or different from each other. For example, 2,2-dichlorovinyl group, 2-fluoro-2-propenyl group, 2-chloro-2-propenyl group, 3-chloro-2-propenyl group, 2-bromo-2-propenyl group, 3-bromo-2 -Propenyl group, 3,3-difluoro-2-propenyl group, 2,3-dichloro-2-propenyl group, 3,3-dichloro-2-propenyl group, 2,3-dibromo-2-propenyl group, 2, 3,3-trifluoro-2-propenyl group, 2,3,3-trichloro-2-propenyl group, 1- (trifluoromethyl) ethenyl group, 3-chloro-2-butenyl group, 3-bromo-2- Butenyl group, 4,4-difluoro-3-butenyl group, 3,4,4-trifluoro-3-butenyl group, 3-chloro-4,4,4-trifluoro-2-butenyl group, 3-bromo- A 2-methyl-2-propenyl group or the like is given as a specific example, and is selected within the range of each designated number of carbon atoms.

The notation of C _a -C _b cycloalkenyl in the present specification represents a cyclic unsaturated hydrocarbon group having 1 to 2 carbon atoms and having 1 to 2 carbon atoms. A monocyclic or complex ring structure from a member ring to a 6-member ring can be formed. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the double bond may be either endo- or exo-. For example, 2-cyclopenten-1-yl group, 3-cyclopenten-1-yl group, 2-cyclohexen-1-yl group, 3-cyclohexen-1-yl group, bicyclo [2.2.1] -5-hepten-2- Specific examples include yl groups and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b halocycloalkenyl is a cyclic and one carbon atom having _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. Alternatively, it represents an unsaturated hydrocarbon group having two or more double bonds, and can form a monocyclic or complex ring structure having 3 to 6 members. Each ring may be optionally substituted with an alkyl group within the range of the specified number of carbon atoms, and the double bond may be either endo- or exo-. Further, the substitution by a halogen atom may be a ring structure part, a side chain part or both of them, and when substituted by two or more halogen atoms, those halogen atoms May be the same as or different from each other. For example, a 2-chlorobicyclo [2.2.1] -5-hepten-2-yl group and the like are given as specific examples, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b alkylidene represents a linear or branched hydrocarbon group having a carbon number of _a to _b , and represents a hydrocarbon group bonded by a double bond, such as a methylidene group or an ethylidene group. Specific examples include groups, propylidene groups, 1-methylethylidene groups, butylidene groups, 1-methylpropylidene groups, pentylidene groups, 1-methylbutylidene groups, 1-ethylethylidene groups, hexylidene groups, etc. In the range of the number of carbon atoms.

In the present specification, C _a -C _b alkynyl is a linear or branched chain consisting of _a to _b carbon atoms, and has one or more triple bonds in the molecule. Represents a hydrocarbon group, for example, ethynyl group, 1-propynyl group, 2-propynyl group, 2-butynyl group, 1-methyl-2-propynyl group, 2-pentynyl group, 1-methyl-2-butynyl group, 1, Specific examples include a 1-dimethyl-2-propynyl group, a 2-hexynyl group, and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, C _a -C _b haloalkynyl represents a linear or branched chain having _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. And an unsaturated hydrocarbon group having one or more triple bonds in the molecule. At this time, when substituted by two or more halogen atoms, the halogen atoms may be the same as or different from each other. Specific examples include 2-chloroethynyl group, 2-bromoethynyl group, 2-iodoethynyl group, 3-chloro-2-propynyl group, 3-bromo-2-propynyl group, 3-iodo-2-propynyl group and the like. Each of which is selected for each specified number of carbon atoms.

The notation of C _a -C _b alkoxy in the present specification represents an alkyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methoxy group, ethoxy group, n-propyloxy group, Specific examples include i-propyloxy group, n-butyloxy group, i-butyloxy group, s-butyloxy group, t-butyloxy group, n-pentyloxy group, n-hexyloxy group, etc. It is selected in the range of the number of atoms.

The notation of C _a -C _b haloalkoxy in the present specification represents a haloalkyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a difluoromethoxy group, a trifluoromethoxy group, a chlorodifluoro Methoxy group, bromodifluoromethoxy group, 2-fluoroethoxy group, 2-chloroethoxy group, 2,2,2-trifluoroethoxy group, 1,1,2,2, -tetrafluoroethoxy group, 2-chloro-1 , 1,2-trifluoroethoxy group, 2-bromo-1,1,2-trifluoroethoxy group, pentafluoroethoxy group, 2,2-dichloro-1,1,2-trifluoroethoxy group, 2,2 , 2-trichloro-1,1-difluoroethoxy group, 2-bromo-1,1,2,2-tetrafluoroethoxy group, 2,2,3,3-tetrafluoropropyloxy group, 1,1,2, 3,3,3-hexafluoropropyloxy group, 2,2,2-trifluoro-1- (trifluoromethyl) ethoxy group, Data fluoropropyl group, 2-bromo-1,1,2,3,3,3-hexafluoro-propyloxy group, etc. As a specific example, may be selected from the range of the specified number of carbon atoms.

The notation of C _a -C _b alkylthio in the present specification represents an alkyl-S-group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylthio group, ethylthio group, n-propylthio group, i Specific examples include -propylthio group, n-butylthio group, i-butylthio group, s-butylthio group, t-butylthio group, n-pentylthio group, n-hexylthio group, etc. Selected.

The notation of C _a -C _b haloalkylthio in the present specification represents a haloalkyl-S-group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylthio group, trifluoromethylthio group, chlorodifluoro Methylthio group, bromodifluoromethylthio group, 2,2,2-trifluoroethylthio group, 1,1,2,2-tetrafluoroethylthio group, 2-chloro-1,1,2-trifluoroethylthio group, Pentafluoroethylthio group, 2-bromo-1,1,2,2-tetrafluoroethylthio group, 1,1,2,3,3,3-hexafluoropropylthio group, heptafluoropropylthio group, 1, Specific examples include 2,2,2-tetrafluoro-1- (trifluoromethyl) ethylthio group, nonafluorobutylthio group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the notation of C _a -C _b alkylsulfinyl represents an alkyl-S (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfinyl group, ethylsulfinyl group, Specific examples include n-propylsulfinyl group, i-propylsulfinyl group, n-butylsulfinyl group, i-butylsulfinyl group, s-butylsulfinyl group, t-butylsulfinyl group and the like. The range is selected.

In the present specification, the expression C _a -C _b haloalkylsulfinyl represents a haloalkyl-S (O) -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylsulfinyl group, trifluoromethyl Sulfinyl group, chlorodifluoromethylsulfinyl group, bromodifluoromethylsulfinyl group, 2,2,2-trifluoroethylsulfinyl group, 2-bromo-1,1,2,2-tetrafluoroethylsulfinyl group, 1,2,2 Specific examples include 2-tetrafluoro-1- (trifluoromethyl) ethylsulfinyl group, nonafluorobutylsulfinyl group, and the like, each selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylsulfonyl in the present specification represents an alkyl-SO ₂ -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfonyl group, ethylsulfonyl group, n- Specific examples include propylsulfonyl group, i-propylsulfonyl group, n-butylsulfonyl group, i-butylsulfonyl group, s-butylsulfonyl group, t-butylsulfonyl group, n-pentylsulfonyl group, n-hexylsulfonyl group and the like. Each of which is selected for each specified number of carbon atoms.

The notation of C _a -C _b haloalkylsulfonyl in the present specification represents a haloalkyl-SO ₂ — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a difluoromethylsulfonyl group or a trifluoromethylsulfonyl group. Chlorodifluoromethylsulfonyl group, bromodifluoromethylsulfonyl group, 2,2,2-trifluoroethylsulfonyl group, 1,1,2,2-tetrafluoroethylsulfonyl group, 2-chloro-1,1,2-trimethyl Specific examples include a fluoroethylsulfonyl group, a 2-bromo-1,1,2,2-tetrafluoroethylsulfonyl group, and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylamino in the present specification represents an amino group in which one of the hydrogen atoms is substituted with an alkyl group having the above meaning consisting of _a to _b carbon atoms, for example, a methylamino group , Ethylamino group, n-propylamino group, i-propylamino group, n-butylamino group, i-butylamino group, t-butylamino group and the like. Selected by range.

In the present specification, the notation of di (C _a -C _b alkyl) amino has the above-mentioned meaning that the number of carbon atoms, which may be the same or different from each other, is ab. Represents an amino group substituted by an alkyl group, for example, dimethylamino group, ethyl (methyl) amino group, diethylamino group, n-propyl (methyl) amino group, i-propyl (methyl) amino group, di (n-propyl) Specific examples include amino groups, n-butyl (methyl) amino groups, i-butyl (methyl) amino groups, t-butyl (methyl) amino groups, and the like, each selected within the range of the specified number of carbon atoms. .

The notation of C _a -C _b alkylimino in the present specification represents an alkyl-N = group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylimino group, ethylimino group, n-propylimino group. , I-propylimino group, n-butylimino group, i-butylimino group, s-butylimino group, n-pentylimino group, n-hexylimino group, etc. Selected.

In the present specification, the expression C _a -C _b alkoxyimino represents an alkoxy-N = group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a methoxyimino group, an ethoxyimino group, and n-propyl. Specific examples include oxyimino group, i-propyloxyimino group, n-butyloxyimino group, n-pentyloxyimino group, n-hexyloxyimino group, etc. Is done.

The notation of C _a -C _b alkylcarbonyl in the present specification represents an alkyl-C (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, acetyl group, propionyl group, butyryl group. Specific examples thereof include isobutyryl group, valeryl group, isovaleryl group, 2-methylbutanoyl group, pivaloyl group, hexanoyl group, heptanoyl group and the like, and each is selected in the range of the designated number of carbon atoms.

The notation of C _a -C _b haloalkylcarbonyl in the present specification represents a haloalkyl-C (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a fluoroacetyl group, a chloroacetyl group, Difluoroacetyl group, dichloroacetyl group, trifluoroacetyl group, chlorodifluoroacetyl group, bromodifluoroacetyl group, trichloroacetyl group, pentafluoropropionyl group, heptafluorobutanoyl group, 3-chloro-2,2-dimethylpropanoyl group Etc. are given as specific examples, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkoxycarbonyl in the present specification represents an alkyl-OC (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a methoxycarbonyl group, an ethoxycarbonyl group, Specific examples include n-propyloxycarbonyl group, i-propyloxycarbonyl group, n-butoxycarbonyl group, i-butoxycarbonyl group, t-butoxycarbonyl group, etc., each selected within the range of the specified number of carbon atoms Is done.

The notation of C _a -C _b haloalkoxycarbonyl in the present specification represents a haloalkyl-OC (O) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as a 2-chloroethoxycarbonyl group, Specific examples include 2,2-difluoroethoxycarbonyl group, 2,2,2-trifluoroethoxycarbonyl group, 2,2,2-trichloroethoxycarbonyl group, etc., each selected within the range of the specified number of carbon atoms Is done.

The notation of C _a -C _b alkylthiocarbonyl in the present specification represents an alkyl-SC (O) -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylthio-C (O) -group , Ethylthio-C (O)-group, n-propylthio-C (O)-group, i-propylthio-C (O)-group, n-butylthio-C (O)-group, i-butylthio-C (O ) -Group, t-butylthio-C (O) -group and the like are listed as specific examples, and each group is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkoxythiocarbonyl in the present specification represents an alkyl-OC (S) — group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methoxy-C (S) — Specific examples include groups, ethoxy-C (S) -groups, n-propyloxy-C (S) -groups, i-propyloxy-C (S) -groups, etc. Selected by range.

In the present specification, the expression C _a -C _b alkyldithiocarbonyl represents an alkyl-SC (S) -group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylthio-C (S)- Group, ethylthio-C (S) -group, n-propylthio-C (S) -group, i-propylthio-C (S) -group, etc. Selected.

The notation of C _a -C _b alkylaminocarbonyl in the present specification represents a carbamoyl group in which one of the hydrogen atoms is substituted with an alkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylcarbamoyl Group, ethylcarbamoyl group, n-propylcarbamoyl group, i-propylcarbamoyl group, n-butylcarbamoyl group, i-butylcarbamoyl group, s-butylcarbamoyl group, t-butylcarbamoyl group, etc. Is selected within the range of the specified number of carbon atoms.

In the present specification, the expression C _a -C _b haloalkylaminocarbonyl represents a carbamoyl group in which one of the hydrogen atoms is substituted with a haloalkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms, such as 2-fluoro Specific examples include ethylcarbamoyl group, 2-chloroethylcarbamoyl group, 2,2-difluoroethylcarbamoyl group, 2,2,2-trifluoroethylcarbamoyl group, etc., selected within the range of each specified number of carbon atoms Is done.

In the present specification, the notation of di (C _a -C _b alkyl) aminocarbonyl means in the above-mentioned meaning that the number of carbon atoms, which may be both the same or different from each other, consists of _a to _b carbon atoms. Represents a carbamoyl group substituted by an alkyl group, for example, N, N-dimethylcarbamoyl group, N-ethyl-N-methylcarbamoyl group, N, N-diethylcarbamoyl group, N, N-di-n-propylcarbamoyl group Specific examples include N, N-di-n-butylcarbamoyl group and the like, and each is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylaminosulfonyl in the present specification represents a sulfamoyl group in which one of the hydrogen atoms is substituted with an alkyl group having the above-mentioned meaning consisting of _a to _b carbon atoms. Famoyl group, ethylsulfamoyl group, n-propylsulfamoyl group, i-propylsulfamoyl group, n-butylsulfamoyl group, i-butylsulfamoyl group, s-butylsulfamoyl group, Specific examples include a t-butylsulfamoyl group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the notation of di (C _a -C _b alkyl) aminosulfonyl means in the above-mentioned meaning that the number of carbon atoms which may be the same or different from each other is _a to _b. Represents a sulfamoyl group substituted by an alkyl group, for example, N, N-dimethylsulfamoyl group, N-ethyl-N-methylsulfamoyl group, N, N-diethylsulfamoyl group, N, N-di- Specific examples include -n-propylsulfamoyl group, N, N-di-n-butylsulfamoyl group and the like, and each is selected within the range of the designated number of carbon atoms.

In the present specification, the notation of tri (C _a -C _b alkyl) silyl is substituted by an alkyl group having the above-mentioned meaning of _a to _b carbon atoms, which may be the same or different from each other. Represents a silyl group, for example, trimethylsilyl group, triethylsilyl group, tri (n-propyl) silyl group, ethyldimethylsilyl group, n-propyldimethylsilyl group, n-butyldimethylsilyl group, i-butyldimethylsilyl group, t- Specific examples include a butyldimethylsilyl group and the like, and each butyldimethylsilyl group is selected within the range of the designated number of carbon atoms.

The notation of C _a -C _b alkylsulfonyloxy in the present specification represents an alkylsulfonyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, methylsulfonyloxy group, ethylsulfonyloxy group Specific examples include an n-propylsulfonyloxy group, an i-propylsulfonyloxy group, and the like, and each is selected within the specified number of carbon atoms.

The notation of C _a -C _b haloalkylsulfonyloxy in the present specification represents a haloalkylsulfonyl-O— group having the above-mentioned meaning consisting of _a to _b carbon atoms, for example, difluoromethylsulfonyloxy group, trifluoromethyl Specific examples include a sulfonyloxy group, a chlorodifluoromethylsulfonyloxy group, a bromodifluoromethylsulfonyloxy group, and the like, and each is selected within the range of the designated number of carbon atoms.

C _a -C _b cycloalkyl (C _d -C _e ) alkyl, hydroxy (C _d -C _e ) alkyl, C _a -C _b alkoxy (C _d -C _e ) alkyl, C _a -C _b herein Haloalkoxy (C _d -C _e ) alkyl, C _a -C _b alkylthio (C _d -C _e ) alkyl, C _a -C _b haloalkylthio (C _d -C _e ) alkyl, C _a -C _b alkylsulfinyl ( C _d -C _e ) alkyl, C _a -C _b haloalkylsulfinyl (C _d -C _e ) alkyl, C _a -C _b alkylsulfonyl (C _d -C _e ) alkyl, C _a -C _b haloalkylsulfonyl (C _d -C _e) alkyl, cyano (C _d ~C _e) alkyl, C _a -C _b alkoxycarbonyl (C _d ~C _e) alkyl, C _a -C _b haloalkoxycarbonyl (C _d ~C _e) alkyl, phenyl (C _d ~C _e) alkyl or (Z ¹⁾ _p1 notation such as phenyl (C _d ~C _e) alkyl substituted by the optional C _a -C been defined above, respectively _b cycloalkyl group, C _a -C _b alkoxy group, C _a -C _b haloalkoxy group, C _a -C _b alkylthio group, C _a -C _b haloalkylthio group, C _a -C _b alkylsulfinyl group, C _a -C _b haloalkylsulfinyl group, C _a -C _b alkylsulfonyl group, C _a -C _b haloalkylsulfonyl group, C _a -C _b alkoxycarbonyl, C _a -C _b haloalkoxycarbonyl group, a hydroxyl group, a cyano group, a phenyl A group or a phenyl group substituted by (Z1) _p1 represents an alkyl group having the above-mentioned meaning consisting of d to e, wherein the hydrogen atom bonded to the carbon atom is arbitrarily substituted, each designation In the range of the number of carbon atoms.

Optionally substituted by R ⁴ herein (C _a ~C _b) alkyl, optionally substituted by R ¹⁴ (C _a ~C _b) alkyl, optionally substituted by R ^14a (C _^a ~ C _b) alkyl, optionally substituted by R ²⁴ (C _a ~C _b) alkyl, optionally substituted by R ³² (C _a ~C _b) optionally substituted by alkyl or R ³⁵ (C _a ~ C _b ) The notation of alkyl is that the number of carbon atoms in which a hydrogen atom bonded to a carbon atom is optionally substituted by any R ⁴ , R ¹⁴ , R ^14a , R ²⁴ , R ³² or R ³⁵ is a to b Represents an alkyl group having the above-mentioned meaning, and is selected in the range of the designated number of carbon atoms. At this time, when two or more substituents R ⁴ , R ¹⁴ , R ^14a , R ²⁴ , R ³² or R ³⁵ on each (C _a -C _b ) alkyl group are present, each R ⁴ , R ¹⁴ , R ^14a , R ²⁴ , R ³² or R ³⁵ may be the same as or different from each other.

In the present specification, the notation of hydroxy (C _d -C _e ) haloalkyl, C _a -C _b alkoxy (C _d -C _e ) haloalkyl or C _a -C _b haloalkoxy (C _d -C _e ) haloalkyl is as described above. The number of carbon atoms in which a hydrogen atom or a halogen atom bonded to a carbon atom is arbitrarily substituted by any C _a -C _b alkoxy group, C _a -C _b haloalkoxy group or hydroxyl group, Haloalkyl groups as defined above, each selected within a range of the specified number of carbon atoms.

As used herein, hydroxy (C _d -C _e ) cycloalkyl, C _a -C _b alkoxy (C _d -C _e ) cycloalkyl, C _a -C _b alkenyl (C _d -C _e ) cycloalkyl or C _a- The notation such as C _b haloalkenyl (C _d -C _e ) cycloalkyl is any C _a -C _b alkoxy group, C _a -C _b alkenyl group, C _a -C _b haloalkenyl group each having the above-mentioned meaning Or, a cycloalkyl group having the above-mentioned meaning consisting of d to e carbon atoms, in which a hydrogen atom bonded to a carbon atom is optionally substituted by a hydroxyl group, is selected within the range of each designated number of carbon atoms. The

Herein is optionally substituted by R ⁴ (C _a ~C _b) cycloalkyl, optionally substituted by R ¹⁴ (C _a ~C _b) cycloalkyl, optionally substituted by R ²⁴ (C _{a to} C _b ) cycloalkyl or (C _{a to} C _b ) cycloalkyl optionally substituted by R ³² and the like are attached to the carbon atom by any R ⁴ , R ¹⁴ , R ²⁴ or R ³² It represents a cycloalkyl group having the above-mentioned meaning consisting of a to b carbon atoms optionally substituted with hydrogen atoms. At this time, the substitution by R ⁴ , R ¹⁴ , R ²⁴ or R ³² may be a ring structure part, a side chain part or both, and each (C _{when a} -C _b) substituents R ⁴ on the cycloalkyl group, R ^14, R ²⁴ or R ³² there are two or more, each of R ^4, R ^14, R ²⁴ or R ³² are also identical to one another, or They may be different from each other.

The notation of phenyl (C _a -C _b ) alkenyl in the present specification is an alkenyl group having the above-mentioned meaning consisting of _a to _b carbon atoms in which a hydrogen atom bonded to a carbon atom by a phenyl group is arbitrarily substituted. Each selected within a range of each specified number of carbon atoms.

Optionally substituted by R ⁴ herein (C _a ~C _b) alkenyl, optionally substituted by R ¹⁴ (C _a ~C _b) alkenyl, optionally substituted by R ²⁴ (C _a ~ C _b ) alkenyl or (C _a -C _b ) alkenyl optionally substituted by R ³² may be represented by any R ⁴ , R ¹⁴ , R ^24, or R ³² , and optionally a hydrogen atom bonded to a carbon atom. It represents an alkenyl group having the above meaning consisting of a to b substituted carbon atoms, and is selected in the range of each designated number of carbon atoms. At this time, when there are two or more substituents R ⁴ , R ¹⁴ , R ²⁴ or R ³² on each (C _a -C _b ) alkenyl group, each R ⁴ , R ¹⁴ , R ²⁴ or R ^{32 is present.} May be the same as or different from each other.

Optionally substituted by R ⁴ herein (C _a ~C _b) alkynyl, optionally substituted by R ¹⁴ (C _a ~C _b) alkynyl, optionally substituted by R ²⁴ (C _a ~ C _b ) Alkynyl or optionally substituted by R ³² (C _a -C _b ) alkynyl is notated by any R ⁴ , R ¹⁴ , R ²⁴ or R ³² , where a hydrogen atom bonded to a carbon atom is optionally It represents an alkynyl group having the above meaning consisting of a to b substituted carbon atoms, and is selected in the range of each designated number of carbon atoms. At this time, when two or more substituents R ⁴ , R ¹⁴ , R ²⁴ or R ³² on each (C _a -C _b ) alkynyl group are present, each R ⁴ , R ¹⁴ , R ²⁴ or R ^{32 is present.} May be the same as or different from each other.

In this specification
[R ² represents that, together with R ¹ , a C _{2 to} C ₇ alkylene chain may be formed to form a 3 to 8 membered ring with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen, sulfur or nitrogen atom and may be optionally substituted by an oxo or thioxo group]
[R ⁷ represents that, together with R ⁶ , a C ₂ -C ₆ alkylene chain may be formed to form a 3- to 7-membered ring together with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen, sulfur or nitrogen atom and may be optionally substituted by an oxo or thioxo group]
as well as
[R ²⁶ represents that, together with R ²⁵ , a C _{2 to} C ₅ alkylene chain may be formed to form a 3 to 6 membered ring together with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen or sulfur atom and may be optionally substituted with an oxo or thioxo group]
Specific examples of the notation of, 2-thione, imidazolidine, imidazolidine-2-one, imidazolidine-2-thione, piperidine, piperidin-2-one, piperidine-2-thione, 2H-3,4,5,6-tetrahydro-1,3 -Oxazin-2-one, 2H-3,4,5,6-tetrahydro-1,3-oxazine-2-thione, morpholine, 2H-3,4,5,6-tetrahydro-1,3-thiazine-2 -One, 2H-3,4,5,6-tetrahydro-1,3-thiazin-2-thione, thiomorpholine, perhydropyrimidin-2-one, piperazine, homopiperidine, homopiperidin-2-one, heptamethylene Imine, etc. The

In this specification
[R ^1a and R ^2a may form a C _{4 to} C ₅ alkylene chain or a C _{4 to} C ₅ alkenylene chain together to form a 5 to 6 membered ring with the carbon atoms to which they are bonded. In this case, the alkylene chain and the alkenylene chain may contain 1 to 3 oxygen atoms, sulfur atoms, or nitrogen atoms.]
Specific examples of the notation include, for example, thiazolidine-2-ylidene, 2,3-dihydrothiazol-2-ylidene, imidazolidine-2-ylidene, 2,3-dihydroimidazol-2-ylidene, 2,3-dihydro-1 , 3,4-thiadiazole-2-ylidene, 1,2-dihydropyridin-2-ylidene, 2,3-dihydropyridazine-3-ylidene, 1,2-dihydropyrazine-2-ylidene, 1,2-dihydropyrimidine- 2-Ilidene, 6H-2,3-dihydro-1,3,4-thiadiazine-2-ylidene, and the like can be mentioned, and each is selected within the range of the specified number of atoms.

In this specification
[R ¹⁰ represents that, together with R ⁹ , a C _{2 to} C ₆ alkylene chain may be formed to form a 3- to 7-membered ring together with the atoms to be bonded. May contain one atom, sulfur atom or nitrogen atom,
[R ¹⁶ represents that, together with R ¹⁵ , a C ₂ -C ₆ alkylene chain may be formed to form a 3- to 7-membered ring with the atoms to be bonded. May contain one atom, sulfur atom or nitrogen atom,
[R ¹⁸ represents that, together with R ¹⁷ , a C _{4 to} C ₅ alkylene chain may be formed to form a 5- to 6-membered ring with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen atom, sulfur atom or nitrogen atom,
[R ²⁰ represents that, together with R ¹⁹ , a C _{4 to} C ₇ alkylene chain may be formed to form a 5- to 8-membered ring together with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen or sulfur atom,
[R ²⁹ represents that, together with R ²⁸ , a C _{2 to} C ₅ alkylene chain may be formed to form a 3- to 6-membered ring with the nitrogen atom to which the alkylene chain is bonded. May contain one oxygen, sulfur or nitrogen atom,
as well as
[R ³⁴ represents that, together with R ³³ , a C _{2 to} C ₅ alkylene chain may be formed to form a 3- to 6-membered ring with the nitrogen atom to which the R ³⁴ is bonded, May contain one oxygen or sulfur atom,
Specific examples of the notation include, for example, aziridine, azetidine, pyrrolidine, oxazolidine, thiazolidine, imidazolidine, piperidine, morpholine, thiomorpholine, piperazine, homopiperidine, heptamethyleneimine, etc. Selected.

In this specification
[R ^17a and R ^17b together form a C ₃ -C ₅ alkylene chain, which indicates that a 4-6 membered ring may be formed with the carbon atoms to which it is bonded. May contain 1 to 3 oxygen, sulfur or nitrogen atoms,
Specific examples of the notation include, for example, cyclopentylidene, tetrahydrofuran-3-ylidene, tetrahydrothiophene-3-ylidene, cyclohexylidene, tetrahydropyran-3-ylidene, tetrahydropyran-4-ylidene, tetrahydrothiopyran-3-ylidene , Tetrahydrothiopyran-4-ylidene, and the like, each selected within a range of the specified number of atoms.

In the compounds included in the present invention, examples of combinations of atoms represented by A ¹ , A ² and A ³ include the following groups.

That is, AI: A ¹ , A ² and A ³ are carbon atoms.

A-II: A ¹ is a nitrogen atom, A ² and A ³ are carbon atoms.

A-III: A ² is a nitrogen atom, and A ¹ and A ³ are carbon atoms.

A-IV: A ¹ and A ³ are nitrogen atoms, and A ² is a carbon atom.

AV: A ¹ and A ² are nitrogen atoms, and A ³ is a carbon atom.

A-VI: A ² and A ³ are nitrogen atoms, and A ¹ is a carbon atom.

In the compounds included in the present invention, the substituent represented by G ¹ represents an aromatic 6-membered ring and an aromatic 5-membered ring, and among these, G ¹ -1, G ¹ -3 and G ¹ -4 in an aromatic 6-membered ring and G ¹ -13 ^{shown, G 1 -14, G 1 -17a} , G 1 -20, aromatic 5-membered ring is preferred represented by G ¹ -21 and G ¹ -22, further An aromatic 6-membered ring represented by G ¹ -1 is particularly preferred.

In the compounds included in the present invention, examples of the substituent represented by G ² include a nitrogen-containing aromatic heterocycle represented by any one of G ² -1 to G ² -9. ^{2 -1, G 2 -2, G} 2 -3, G 2 -4, G 2 -5, preferably nitrogen-containing aromatic heterocyclic ring represented by G ² -7 and G ² -8, further, G ² - 2, G ² -5 or G ² -8 represented by pyrazole ring, 1,2,4-triazole ring and 1,2,3,4-tetrazole ring is particularly preferred.

  In the compounds included in the present invention, examples of the range of the substituent represented by X include the following groups. At this time, when m represents an integer of 2 or more in each of the following cases, each X may be the same as or different from each other.

  That is, X-I: a halogen atom.

X-II: halogen atom and C ₁ -C ₆ haloalkyl.

X-III: halogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, —OR ⁵ and —S (O) _r R ⁵ [where R ⁵ is C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, r is an integer of 0 to 2. ].

X-IV: halogen atom, nitro, -SF _5, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₆₎ haloalkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₆₎ haloalkyl, C ₃ -C ₈ halocycloalkyl, -OR ^5, -OSO ₂ R ⁵ and -S (O) _{r R} ⁵ [wherein, R ⁵ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₃ haloalkoxy (C ₁ ~C ₃₎ haloalkyl, r is an integer of 0 to 2. ].

  In the compound included in the present invention, m representing the number of substituents represented by X includes an integer of 0 to 5, and among these, m is preferably 1, 2 or 3.

  In the compounds included in the present invention, examples of the range of the substituent represented by Y include the following groups. At this time, when n represents an integer of 2 or more in each of the following cases, each Y may be the same as or different from each other.

That, YI: C ₁ ~C ₆ alkyl.

Y-II: halogen atom, nitro, C ₁ -C ₆ alkyl and C ₁ -C ₆ haloalkyl.

Y-III: halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ ^{haloalkyl, -OR 5, -SR 5, -NH} 2 and -N (R ⁷⁾ R ⁶ [wherein, R ⁵ C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, R ⁶ is C ₁ -C ₆ represents alkyl, -CHO, a C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, R ⁷ represents a hydrogen atom or a C ₁ -C ₆ alkyl. ].

Y-IV: halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, optionally substituted by R _⁴ (C ₁ ~C ⁴⁾ alkyl [wherein, R ⁴ is -OH represents C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio. ], C ₃ ~C ₆ alkynyl, -OR ^5, -SR ⁵ [wherein, R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl. _{], - NH 2, -N (} R 7) R 6 [ wherein, R ⁶ is C ₁ -C ₆ alkyl, -CHO, C ₁ ~C ₆ alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ ~ C ₆ alkoxycarbonyl, C ₁ -C ₆ alkylthiocarbonyl, C ₁ -C ₆ alkoxythiocarbonyl, C ₁ -C ₆ alkyl dithio carbonyl, C ₁ -C ₆ alkyl sulfonyl or C ₁ -C ₆ haloalkylsulfonyl, R ⁷ represents a hydrogen atom or a C ₁ -C ₆ alkyl. ] And -C (S) NH _2.

  In the compound included in the present invention, n representing the number of substituents represented by Y includes an integer of 0 to 4, and among these, n is preferably 0 or 1.

In the compounds included in the present invention, as the scope of the substituent represented by Z ^a, include the following groups. At this time, when p in each case the following represents an integer of 2 or more, each Z ^a may have also or different from each other the same as each other.

That is, Z ^a -I: —C (O) N (R ² ) R ¹ [wherein R ¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, and R ² represents a hydrogen atom or C ₁ ~C represents a ₆ alkyl. ].

Z ^a -II: halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl and C ₁ -C ₆ haloalkylsulfonyl.

Z ^a -III: —C (O) N (R ² ) R ¹ and —C (S) N (R ² ) R ¹ [where R ¹ is a hydrogen atom, C ₁ -C ₆ alkyl, R ¹⁴ optionally substituted (C ₁ ~C ₆₎ alkyl, C ₃ -C ₆ cycloalkyl, E3, C ₃ ~C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, -C (R ¹⁶ ) = NOR ¹⁵ , -C (O) OR ¹⁵ , -C (O) NH ₂ , -C (O) N (R ¹⁶ ) R ¹⁵ , -C (O) NHC (O) R ¹⁵ , -C ( O) N (R ¹⁶ ) C (O) OR ¹⁵ , -N (R ¹⁸ ) R ¹⁷ , (Z) represents phenyl, D6-D8, D10, D32, D34 or D35 substituted by _p1 , R ² is hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ^14a (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ ^{alkynyl, -C (O) R 15a,} -C (O) oR 15a or C ₁ -C ₆ represents a haloalkylthio, R ¹³ represents a C ₁ -C ₆ alkyl, R ¹⁴ is a halogen atom, cyano, C ₃ -C _{6 cycloalkyl, E3, E6, C 1 ~C} 6 alkoxy, C _{1 to} C ₆ haloalkoxy, -NHC (O) OR ³³ , -C (R ³¹ ) = NOR ³⁰ , -C (O) N (R ²⁹ ) R ²⁸ , Fe , Phenyl substituted by _{(Z) p1, D1, D8} , D10, D13, D16, D22, represents the D32 or D34, R ^14a represents cyano or -OR ^25, R ¹⁵ is C ₁ -C ₆ alkyl , C ₁ -C ₆ haloalkyl or (C ₁ -C ₄ ) alkyl optionally substituted by R ³² , R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ -C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl or C ₂ -C ₆ alkenyl, R ¹⁶ represents a hydrogen atom or a C ₁ -C ₆ alkyl, R ¹⁷ is C ₁ -C ₆ haloalkyl, phenyl, (Z) represents phenyl substituted by _p1 , D32 or D34, R ¹⁸ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, R ²² represents C ₁ ~C ₆ A Represents Kill, R ²⁵ is C ₁ -C ₄ alkyl represents a C ₁ -C ₄ haloalkyl or ^{-C (O) R 33, R} 28 is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl, R ²⁹ represents a hydrogen atom or a C ₁ -C ₄ alkyl, R ³⁰ represents a C ₁ -C ₄ alkyl, R ³¹ is a hydrogen atom or a C ₁ ~ represent C ₄ alkyl, R ³² represents phenyl substituted by (Z) _p1, R ³³ represents a C ₁ -C ₄ alkyl, Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C _{1 to} C ₆ haloalkyl, C _{1 to} C ₆ alkoxy or C _{1 to} C ₆ alkylsulfonyloxy, and when p1 represents an integer of 2 or more, each Z may be the same as or different from each other. P1 represents an integer of 1 to 3, p2, p3, p4 and p5 represent an integer of 0 or 1, q2 represents an integer of 0 or 1, q3 represents 0, and t represents 0 . ].

Z ^a -IV: halogen atoms, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl [wherein, R ⁴ is - OH, represents a C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio. ], C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl and C ₁ -C ₆ haloalkylsulfonyl.

Z ^a -V: —C (O) N (R ² ) R ¹ and —C (S) N (R ² ) R ¹ [where R ¹ is a hydrogen atom, C ₁ -C ₆ alkyl, R ¹⁴ optionally substituted (C ₁ ~C ₆₎ alkyl, C ₃ -C _{6 cycloalkyl, E3, E11, C 3 ~C} 6 represents alkenyl, C ₃ -C ₆ haloalkenyl or C ₃ -C ₆ alkynyl, R ² is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ^14a , C ₃ -C ₆ alkynyl, -C (O) R ^15a , -C (O) Represents OR ^15a or C ₁ -C ₆ haloalkylthio, R ¹⁴ is a halogen atom, cyano, C ₃ -C ₆ cycloalkyl, E 3, E 6, —OH, —OR ²⁵ , C ₁ -C ₆ alkylthio, C _1- C ₆ alkylsulfinyl, C ₁ -C ₆ ^{alkylsulfonyl, -N (R 26) R 25} , C 1 ~C 6 alkyl ^{carbonyl, -C (R 31) = NOR} 30, -C (O) N (R 29) Table of ^{R 28, -C (S) NH} 2, phenyl, phenyl substituted by _{(Z) p1, D1, D5} , D7, D8, D10, D13, D16, D17, D22, D32 or D34 , R ¹³ represents a C ₁ -C ₆ alkyl, R ^14a represents cyano or C ₁ -C ₄ alkoxy, R ^15a represents C ₁ -C ₆ alkyl or C ₃ -C ₆ cycloalkyl, R ²² is C ₁ -C ₆ alkyl, R ²⁵ is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, -C (O) R ³³ or - Represents C (O) OR ³³ , R ²⁸ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl, R ²⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl, R ³⁰ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₁ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, R ³¹ represents a hydrogen atom or C ₁ -C ₄ alkyl, R ³³ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₃ -C ₆ cycloalkyl, Z represents a halogen atom, nitro, cyano C ₁ -C ₆ alkyl or C ₁ -C ₆ halo When p1 to p4 represent an integer of 2 or more, each Z may be the same as or different from each other, p1 represents an integer of 1 to 3, p2, p3 and p4 Represents an integer of 0 to 2, p5 represents an integer of 0 or 1, q2 represents an integer of 0 to 3, q3 and q4 represent an integer of 0 to 2, and t represents 0. ].

Z ^a -VI: —C (O) N (R ² ) R ¹ and —C (S) N (R ² ) R ¹ [where R ¹ is a hydrogen atom, —C (R ¹⁶ ) = NOR ¹⁵ , -C (O) OR ¹⁵ , -C (O) NH ₂ , -C (O) N (R ¹⁶ ) R ¹⁵ , -C (O) NHC (O) R ¹⁵ , -C (O) N (R ¹⁶ ) Represents C (O) OR ¹⁵ , —C (S) NH ₂ or —C (S) N (R ¹⁶ ) R ¹⁵ , R ² optionally substituted by a hydrogen atom, C ₁ -C ₆ alkyl, R ^14a been (C ₁ -C ₄₎ represents alkyl, C ₃ -C ₆ ^{alkynyl, -C (O) R 15a,} -C a (O) oR ^15a or C ₁ -C ₆ haloalkylthio, R ^14a is cyano or C ₁ -C ₄ alkoxy, R ¹⁵ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, optionally substituted by R ³² (C _{1 ~C 4)} alkyl or C ₂ -C ₆ alkenyl , R ^15a represents C ₁ -C ₆ alkyl or C ₃ -C ₆ cycloalkyl, R ¹⁶ represents a hydrogen atom or C ₁ -C ₆ alkyl, R ³² represents C ₃ -C ₆ cycloalkyl, C _1- C ₄ alkoxy, C ₁ -C ₄ alkoxycarbonyl, phenyl or D32 substituted by (Z) _p1 And, Z represents a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, when p1 and p2 represents an integer of 2 or more, each Z is or be the same as each other They may be different from each other, p1 represents an integer of 1 to 3, p2 represents an integer of 0 to 2, and t represents 0. ].

Z ^a -VII: —C (O) N (R ² ) R ¹ and —C (S) N (R ² ) R ¹ [wherein R ¹ represents a hydrogen atom or —N (R ¹⁸ ) R ¹⁷ , R ² is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ^14a , C ₃ -C ₆ alkynyl, -C (O) R ^15a , -C (O ) OR ^15a or C ₁ -C ₆ haloalkylthio, R ^14a represents cyano or C ₁ -C ₄ alkoxy, R ^15a represents C ₁ -C ₆ alkyl or C ₃ -C ₆ cycloalkyl, R ¹⁷ C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, (Z) phenyl substituted by _p1, represents the D32 or D34, R ¹⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₃ ~ C ₆ alkenyl or C ₃ -C ₆ alkynyl is represented, Z represents a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl, and p ₁ , p 2 and p 3 represent an integer of 2 or more When each Z is the same or different from each other At best, p1 represents an integer of 1 to 3, p2 and p3 represents an integer of 0 to 2, t represents 0. ].

Z ^a -VIII: —C (O) N (R ² ) R ¹ and —C (S) N (R ² ) R ¹ [where R ¹ is a hydrogen atom, phenyl substituted by (Z) _p ¹ , D5-D8, D10, D17, represents D32~D34 or D35, R ² is a hydrogen atom, optionally substituted by C ₁ -C _{6 ^{alkyl, R 14a (C 1 ~C 4}} ) alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, -C (O) R ^15a , -C (O) OR ^15a or C ₁ -C ₆ haloalkylthio, R ¹³ is C _1- C ₆ alkyl represents, R ^14a represents a halogen atom, cyano or —OR ²⁵ , R ^15a represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, (Z) _Represents phenyl substituted by _p1 or D32, R ²⁵ is C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, -C (O) R ³³ Or -C (O) OR ³³ , R ³³ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₆ cycloalkyl or phenyl, Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, -C (O) NH _2, represents a -C (S) NH ₂ or -S (O) ₂ NH _2, when the p1~p4 is an integer of 2 or more, Each Z may be the same as or different from each other, p1 represents an integer of 1 to 3, p2, p3 and p4 represent an integer of 0 to 2, and p5 represents an integer of 0 or 1 And t represents 0 ].

In the compounds included in the present invention, the p representing the number of substituents represented by Z ^a include integer of 0 to 4, of these p2 and p3 is preferably an integer of 0 to 2, p4 and p5 is preferably 0 or 1, p3 is particularly preferably 1, and p4 and p5 are particularly preferably 0.

In the compounds included in the present invention, examples of the range of the substituent represented by R ³ include the following groups.

That is, R ³ -I: —CF ₃ and —CF ₂ Cl.

R ³ -II: C ₁ -C ₆ alkyl optionally substituted with two or more optional halogen atoms.

R ³ -III: C ₁ -C ₆ haloalkyl.

R ³ -IV: C ₁ -C ₆ haloalkyl and C ₃ -C ₈ halocycloalkyl.

R ³ -V: C ₁ ~C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ haloalkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~C ₄₎ haloalkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄₎ haloalkyl, C ₁ -C ₄ haloalkylthio (C ₁ -C ₄₎ haloalkyl, cyano (C ₁ -C ₆₎ haloalkyl, C ₃ -C ₆ cycloalkyl and C _{3 ~C 8} halocycloalkyl.

Each group which shows the range of each substituent in these compounds included in the present invention can be arbitrarily combined, and each represents the range of the present compound. X, Y, as an example of a combination of range for G ² and Z ^a, for example include combinations shown in Table 1 below. However, the combinations in Table 1 are for illustrative purposes, and the present invention is not limited to these.

Here, in the table, of substituents Z ^a - notation represents unsubstituted.
Table 1 Table 1 (continued)
―――――――――――――――――――――――――――――――――――――――
XYG ² Z ^a XYG ² Z ^a
―――――――――――――――――――――――――――――――――――――――
XI YI G ² -1 − X-II YI G ² -4 Z ^a -III
XI YI G ² -1 Z ^a -I X-II YI G ² -5 −
XI YI G ² -1 Z ^a -II X-II YI G ² -5 Z ^a -I
XI YI G ² -1 Z ^a -III X-II YI G ² -5 Z ^a -II
XI YI G ² -1 Z ^a -IV X-II YI G ² -5 Z ^a -III
XI YI G ² -1 Z ^a -V X-II YI G ² -5 Z ^a -V
XI YI G ² -1 Z ^a -VI X-II YI G ² -5 Z ^a -VI
XI YI G ² -1 Z ^a -VII X-II YI G ² -5 Z ^a -VII
XI YI G ² -1 Z ^a -VIII X-II YI G ² -5 Z ^a -VIII
XI YI G ² -2 − X-II YI G ² -6 −
XI YI G ² -2 Z ^a -I X-II YI G ² -6 Z ^a -I
XI YI G ² -2 Z ^a -II X-II YI G ² -6 Z ^a -II
XI YI G ² -2 Z ^a -III X-II YI G ² -6 Z ^a -III
XI YI G ² -2 Z ^a -IV X-II YI G ² -6 Z ^a -V
XI YI G ² -2 Z ^a -V X-II YI G ² -6 Z ^a -VI
XI YI G ² -2 Z ^a -VI X-II YI G ² -6 Z ^a -VII
XI YI G ² -2 Z ^a -VII X-II YI G ² -6 Z ^a -VIII
XI YI G ² -2 Z ^a -VIII X-II YI G ² -7 −
XI YI G ² -3 − X-II YI G ² -7 Z ^a -I
XI YI G ² -3 Z ^a -I X-II YI G ² -7 Z ^a -II
XI YI G ² -3 Z ^a -II X-II YI G ² -7 Z ^a -III
XI YI G ² -3 Z ^a -III X-II YI G ² -7 Z ^a -IV
XI YI G ² -3 Z ^a -IV X-II YI G ² -8 −
XI YI G ² -3 Z ^a -V X-II YI G ² -8 Z ^a -I
XI YI G ² -3 Z ^a -VI X-II YI G ² -8 Z ^a -II
XI YI G ² -3 Z ^a -VII X-II YI G ² -8 Z ^a -III
XI YI G ² -3 Z ^a -VIII X-II YI G ² -8 Z ^a -IV
XI YI G ² -4 − X-II YI G ² -9 −
XI YI G ² -4 Z ^a -I X-II YI G ² -9 Z ^a -I
XI YI G ² -4 Z ^a -II X-II YI G ² -9 Z ^a -II
XI YI G ² -4 Z ^a -III X-II YI G ² -9 Z ^a -III
XI YI G ² -4 Z ^a -IV X-II YI G ² -9 Z ^a -V
XI YI G ² -4 Z ^a -V X-II YI G ² -9 Z ^a -VI
XI YI G ² -4 Z ^a -VI X-II YI G ² -9 Z ^a -VII
XI YI G ² -4 Z ^a -VII X-II YI G ² -9 Z ^a -VIII
XI YI G ² -4 Z ^a -VIII X-II Y-II G ² -1 Z ^a -I
XI YI G ² -5 − X-II Y-II G ² -1 Z ^a -II
XI YI G ² -5 Z ^a -I X-II Y-II G ² -1 Z ^a -III
XI YI G ² -5 Z ^a -II X-II Y-II G ² -2 Z ^a -I
XI YI G ² -5 Z ^a -III X-II Y-II G ² -2 Z ^a -II
XI YI G ² -5 Z ^a -IV X-II Y-II G ² -2 Z ^a -III
XI YI G ² -5 Z ^a -V X-II Y-II G ² -2 Z ^a -V
XI YI G ² -5 Z ^a -VI X-II Y-II G ² -2 Z ^a -VI
XI YI G ² -5 Z ^a -VII X-II Y-II G ² -2 Z ^a -VII
XI YI G ² -5 Z ^a -VIII X-II Y-II G ² -2 Z ^a -VIII
XI YI G ² -6 − X-II Y-II G ² -3 −
XI YI G ² -6 Z ^a -I X-II Y-II G ² -3 Z ^a -I
XI YI G ² -6 Z ^a -II X-II Y-II G ² -3 Z ^a -II
XI YI G ² -6 Z ^a -III X-II Y-II G ² -3 Z ^a -III
XI YI G ² -6 Z ^a -IV X-II Y-II G ² -4 −
XI YI G ² -6 Z ^a -V X-II Y-II G ² -4 Z ^a -I
XI YI G ² -6 Z ^a -VI X-II Y-II G ² -4 Z ^a -II
XI YI G ² -6 Z ^a -VII X-II Y-II G ² -4 Z ^a -III
XI YI G ² -6 Z ^a -VIII X-II Y-II G ² -5 −
XI YI G ² -7 − X-II Y-II G ² -5 Z ^a -I
XI YI G ² -7 Z ^a -I X-II Y-II G ² -5 Z ^a -II
XI YI G ² -7 Z ^a -II X-II Y-II G ² -5 Z ^a -III
XI YI G ² -7 Z ^a -III X-II Y-II G ² -5 Z ^a -V
XI YI G ² -7 Z ^a -IV X-II Y-II G ² -5 Z ^a -VI
XI YI G ² -7 Z ^a -V X-II Y-II G ² -5 Z ^a -VII
XI YI G ² -7 Z ^a -VI X-II Y-II G ² -5 Z ^a -VIII
XI YI G ² -7 Z ^a -VII X-II Y-II G ² -6 −
XI YI G ² -7 Z ^a -VIII X-II Y-II G ² -6 Z ^a -I
XI YI G ² -8 − X-II Y-II G ² -6 Z ^a -II
XI YI G ² -8 Z ^a -I X-II Y-II G ² -6 Z ^a -III
XI YI G ² -8 Z ^a -II X-II Y-II G ² -6 Z ^a -V
XI YI G ² -8 Z ^a -III X-II Y-II G ² -6 Z ^a -VI
XI YI G ² -8 Z ^a -IV X-II Y-II G ² -6 Z ^a -VII
XI YI G ² -8 Z ^a -V X-II Y-II G ² -6 Z ^a -VIII
XI YI G ² -8 Z ^a -VI X-II Y-II G ² -7 −
XI YI G ² -8 Z ^a -VII X-II Y-II G ² -7 Z ^a -I
XI YI G ² -8 Z ^a -VIII X-II Y-II G ² -7 Z ^a -II
XI YI G ² -9 − X-II Y-II G ² -7 Z ^a -III
XI YI G ² -9 Z ^a -I X-II Y-II G ² -7 Z ^a -IV
XI YI G ² -9 Z ^a -II X-II Y-II G ² -8 −
XI YI G ² -9 Z ^a -III X-II Y-II G ² -8 Z ^a -I
XI YI G ² -9 Z ^a -IV X-II Y-II G ² -8 Z ^a -II
XI YI G ² -9 Z ^a -V X-II Y-II G ² -8 Z ^a -III
XI YI G ² -9 Z ^a -VI X-II Y-II G ² -8 Z ^a -IV
XI YI G ² -9 Z ^a -VII X-II Y-II G ² -9 −
XI YI G ² -9 Z ^a -VIII X-II Y-II G ² -9 Z ^a -I
XI Y-II G ² -1 Z ^a -I X-II Y-II G ² -9 Z ^a -II
XI Y-II G ² -1 Z ^a -II X-II Y-II G ² -9 Z ^a -III
XI Y-II G ² -1 Z ^a -III X-II Y-II G ² -9 Z ^a -V
XI Y-II G ² -2 Z ^a -I X-II Y-II G ² -9 Z ^a -VI
XI Y-II G ² -2 Z ^a -II X-II Y-II G ² -9 Z ^a -VII
XI Y-II G ² -2 Z ^a -III X-II Y-II G ² -9 Z ^a -VIII
XI Y-II G ² -2 Z ^a -V X-II Y-III G ² -1 Z ^a -I
XI Y-II G ² -2 Z ^a -VI X-II Y-III G ² -2 Z ^a -I
XI Y-II G ² -2 Z ^a -VII X-II Y-III G ² -2 Z ^a -III
XI Y-II G ² -2 Z ^a -VIII X-II Y-III G ² -2 Z ^a -V
XI Y-II G ² -3 − X-II Y-III G ² -2 Z ^a -VI
XI Y-II G ² -3 Z ^a -I X-II Y-III G ² -3 Z ^a -I
XI Y-II G ² -3 Z ^a -II X-II Y-III G ² -4 −
XI Y-II G ² -3 Z ^a -III X-II Y-III G ² -4 Z ^a -I
XI Y-II G ² -4 − X-II Y-III G ² -5 −
XI Y-II G ² -4 Z ^a -I X-II Y-III G ² -5 Z ^a -I
XI Y-II G ² -4 Z ^a -II X-II Y-III G ² -5 Z ^a -III
XI Y-II G ² -4 Z ^a -III X-II Y-III G ² -6 Z ^a -I
XI Y-II G ² -5 − X-II Y-III G ² -7 −
XI Y-II G ² -5 Z ^a -I X-II Y-III G ² -8 −
XI Y-II G ² -5 Z ^a -II X-II Y-III G ² -8 Z ^a -I
XI Y-II G ² -5 Z ^a -III X-II Y-III G ² -9 −
XI Y-II G ² -5 Z ^a -V X-II Y-III G ² -9 Z ^a -I
XI Y-II G ² -5 Z ^a -VI X-II Y-III G ² -9 Z ^a -III
XI Y-II G ² -5 Z ^a -VII X-II Y-IV G ² -2 Z ^a -I
XI Y-II G ² -5 Z ^a -VIII X-II Y-IV G ² -2 Z ^a -III
XI Y-II G ² -6 − X-II Y-IV G ² -4 −
XI Y-II G ² -6 Z ^a -I X-II Y-IV G ² -5 −
XI Y-II G ² -6 Z ^a -II X-II Y-IV G ² -8 −
XI Y-II G ² -6 Z ^a -III X-II Y-IV G ² -9 −
XI Y-II G ² -6 Z ^a -V X-III YI G ² -1 Z ^a -I
XI Y-II G ² -6 Z ^a -VI X-III YI G ² -1 Z ^a -III
XI Y-II G ² -6 Z ^a -VII X-III YI G ² -2 Z ^a -I
XI Y-II G ² -6 Z ^a -VIII X-III YI G ² -2 Z ^a -III
XI Y-II G ² -7 − X-III YI G ² -2 Z ^a -V
XI Y-II G ² -7 Z ^a -I X-III YI G ² -2 Z ^a -VI
XI Y-II G ² -7 Z ^a -II X-III YI G ² -2 Z ^a -VII
XI Y-II G ² -7 Z ^a -III X-III YI G ² -2 Z ^a -VIII
XI Y-II G ² -7 Z ^a -IV X-III YI G ² -3 Z ^a -I
XI Y-II G ² -8 − X-III YI G ² -3 Z ^a -III
XI Y-II G ² -8 Z ^a -I X-III YI G ² -4 −
XI Y-II G ² -8 Z ^a -II X-III YI G ² -4 Z ^a -I
XI Y-II G ² -8 Z ^a -III X-III YI G ² -4 Z ^a -III
XI Y-II G ² -8 Z ^a -IV X-III YI G ² -5 −
XI Y-II G ² -9 − X-III YI G ² -5 Z ^a -I
XI Y-II G ² -9 Z ^a -I X-III YI G ² -5 Z ^a -III
XI Y-II G ² -9 Z ^a -II X-III YI G ² -6 −
XI Y-II G ² -9 Z ^a -III X-III YI G ² -6 Z ^a -I
XI Y-II G ² -9 Z ^a -V X-III YI G ² -6 Z ^a -III
XI Y-II G ² -9 Z ^a -VI X-III YI G ² -7 −
XI Y-II G ² -9 Z ^a -VII X-III YI G ² -7 Z ^a -I
XI Y-II G ² -9 Z ^a -VIII X-III YI G ² -7 Z ^a -II
XI Y-III G ² -1 Z ^a -I X-III YI G ² -8 −
XI Y-III G ² -1 Z ^a -III X-III YI G ² -8 Z ^a -I
XI Y-III G ² -2 Z ^a -I X-III YI G ² -8 Z ^a -II
XI Y-III G ² -2 Z ^a -III X-III YI G ² -8 Z ^a -III
XI Y-III G ² -2 Z ^a -V X-III YI G ² -9 −
XI Y-III G ² -2 Z ^a -VI X-III YI G ² -9 Z ^a -I
XI Y-III G ² -2 Z ^a -VII X-III YI G ² -9 Z ^a -II
XI Y-III G ² -2 Z ^a -VIII X-III YI G ² -9 Z ^a -III
XI Y-III G ² -3 Z ^a -I X-III YI G ² -9 Z ^a -V
XI Y-III G ² -3 Z ^a -III X-III YI G ² -9 Z ^a -VI
XI Y-III G ² -4 − X-III Y-II G ² -1 Z ^a -I
XI Y-III G ² -4 Z ^a -I X-III Y-II G ² -2 Z ^a -I
XI Y-III G ² -4 Z ^a -III X-III Y-II G ² -2 Z ^a -III
XI Y-III G ² -5 − X-III Y-II G ² -2 Z ^a -V
XI Y-III G ² -5 Z ^a -I X-III Y-II G ² -2 Z ^a -VI
XI Y-III G ² -5 Z ^a -III X-III Y-II G ² -3 Z ^a -I
XI Y-III G ² -6 − X-III Y-II G ² -4 −
XI Y-III G ² -6 Z ^a -I X-III Y-II G ² -4 Z ^a -I
XI Y-III G ² -6 Z ^a -III X-III Y-II G ² -5 −
XI Y-III G ² -7 − X-III Y-II G ² -5 Z ^a -I
XI Y-III G ² -7 Z ^a -I X-III Y-II G ² -5 Z ^a -III
XI Y-III G ² -7 Z ^a -II X-III Y-II G ² -6 Z ^a -I
XI Y-III G ² -8 − X-III Y-II G ² -7 −
XI Y-III G ² -8 Z ^a -I X-III Y-II G ² -8 −
XI Y-III G ² -8 Z ^a -II X-III Y-II G ² -8 Z ^a -I
XI Y-III G ² -8 Z ^a -III X-III Y-II G ² -9 −
XI Y-III G ² -9 − X-III Y-II G ² -9 Z ^a -I
XI Y-III G ² -9 Z ^a -I X-III Y-II G ² -9 Z ^a -III
XI Y-III G ² -9 Z ^a -II X-III Y-III G ² -2 Z ^a -I
XI Y-III G ² -9 Z ^a -III X-III Y-III G ² -2 Z ^a -III
XI Y-III G ² -9 Z ^a -V X-III Y-III G ² -4 −
XI Y-III G ² -9 Z ^a -VI X-III Y-III G ² -5 −
XI Y-IV G ² -2 Z ^a -I X-III Y-III G ² -8 −
XI Y-IV G ² -2 Z ^a -III X-III Y-III G ² -9 −
XI Y-IV G ² -4 − X-III Y-IV G ² -2 Z ^a -I
XI Y-IV G ² -5 − X-III Y-IV G ² -5 −
XI Y-IV G ² -8 − X-III Y-IV G ² -8 −
XI Y-IV G ² -9 − X-IV YI G ² -2 Z ^a -I
X-II YI G ² -1 Z ^a -I X-IV YI G ² -2 Z ^a -III
X-II YI G ² -1 Z ^a -II X-IV YI G ² -4 −
X-II YI G ² -1 Z ^a -III X-IV YI G ² -5 −
X-II YI G ² -2 Z ^a -I X-IV YI G ² -8 −
X-II YI G ² -2 Z ^a -II X-IV YI G ² -9 −
X-II YI G ² -2 Z ^a -III X-IV Y-II G ² -2 Z ^a -I
X-II YI G ² -2 Z ^a -V X-IV Y-II G ² -2 Z ^a -III
X-II YI G ² -2 Z ^a -VI X-IV Y-II G ² -4 −
X-II YI G ² -2 Z ^a -VII X-IV Y-II G ² -5 −
X-II YI G ² -2 Z ^a -VIII X-IV Y-II G ² -8 −
X-II YI G ² -3 − X-IV Y-II G ² -9 −
X-II YI G ² -3 Z ^a -I X-IV Y-III G ² -2 Z ^a -I
X-II YI G ² -3 Z ^a -II X-IV Y-III G ² -5-
X-II YI G ² -3 Z ^a -III X-IV Y-III G ² -8 −
X-II YI G ² -4-X-IV Y-IV G ² -2 Z ^a -I
X-II YI G ² -4 Z ^a -I X-IV Y-IV G ² -5-
X-II YI G ² -4 Z ^a -II X-IV Y-IV G ² -8 −
―――――――――――――――――――――――――――――――――――――――
The compound of the present invention can be produced, for example, by the following method.

  Manufacturing method A

General formula (3) [wherein A ¹ , A ² , A ³ , G ¹ , X, Y, R ³ , m and n represent the same meaning as described above, J ¹ represents a fluorine atom, a chlorine atom, a bromine atom represents an iodine atom or a C ₁ -C ₄ haloalkylsulfonate group (e.g., trifluoromethanesulfonyloxy group). And a compound of the general formula (4) [wherein G ² , Z ^a and p represent the same meaning as described above. The compound represented by formula (1) [wherein A ¹ , A ^{2, a 3, G 1,} G 2, X, Y, Z a, R 3, m, n and p are as defined above. This invention compound represented by this can be obtained.

  The amount of the reaction substrate may be 1 to 50 equivalents of the compound represented by the general formula (4) with respect to 1 equivalent of the compound represented by the general formula (3).

  In the case of using a solvent, the solvent to be used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, aromatic hydrocarbons such as benzene, toluene and xylene, and aliphatic hydrocarbons such as hexane and heptane. , Cycloaliphatic alicyclic hydrocarbons, chlorobenzene, dichlorobenzene and other aromatic halogenated hydrocarbons, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene Aliphatic halogenated hydrocarbons such as diethyl ether, 1,2-dimethoxyethane, tetrahydrofuran, ethers such as 1,4-dioxane, esters such as ethyl acetate and ethyl propionate, dimethylformamide, dimethylacetamide, N Amides such as 2-methyl-2-pyrrolidone, triethyla Amines such as amine, tributylamine and N, N-dimethylaniline, pyridines such as pyridine and picoline, alcohols such as methanol, ethanol and ethylene glycol, acetonitrile, dimethyl sulfoxide, sulfolane, 1,3-dimethyl-2- Examples include imidazolidinone and water. These solvents may be used alone or as a mixture of two or more thereof.

  When using a base, for example, alkali metal hydrides such as sodium hydride and potassium hydride, alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal alkoxides such as sodium ethoxide and potassium tertiary butoxide, Alkali metal amides such as lithium diisopropylamide, lithium hexamethyldisilazane, sodium amide, organometallic compounds such as tertiary butyl lithium, alkali metal carbonates such as sodium carbonate, potassium carbonate, sodium bicarbonate, triethylamine, tributylamine, Organic bases such as N, N-dimethylaniline, pyridine, 4- (dimethylamino) pyridine, imidazole, and 1,8-diazabicyclo [5,4,0] -7-undecene are represented by the general formula (3). 1 to 10 equivalents can be used with respect to the compound. .

  The reaction temperature can be set to an arbitrary temperature from −60 ° C. to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but is usually arbitrarily within the range of 5 minutes to 100 hours. Can be set.

  In general, for example, 1 to 10 equivalents of the compound represented by the general formula (4) is used per 1 equivalent of the compound represented by the general formula (3), and tetrahydrofuran, 1,4-dioxane, acetonitrile or N In a polar solvent such as N-dimethylformamide, if necessary, sodium hydride, potassium tertiary butoxide, potassium hydroxide, potassium carbonate, triethylamine, pyridine and the like as a base are added to 1 equivalent of the compound represented by the general formula (3). The reaction is preferably carried out in the temperature range of 0 to 90 ° C. for 10 minutes to 24 hours using 1 to 3 equivalents.

  Manufacturing method B

General formula (5) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p represent the same meaning as described above. The compound represented by the general formula (6) [formula (6) is obtained by halogenating with a halogenating agent in the presence of a base if necessary using a solvent inert to the reaction, if necessary. In the formula, A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p represent the same meaning as described above, and J ² represents a halogen atom such as a chlorine atom or a bromine atom. ] Can be obtained.

  Examples of the halogenating agent include N-halosuccinimides such as N-chlorosuccinimide and N-bromosuccinimide, alkali metal hypohalites such as sodium hypochlorite, and t-butyl hypochlorite. Hypohalous acid esters such as esters and simple halogens such as chlorine gas can be used in an amount of 1 to 10 equivalents with respect to the compound represented by the general formula (5).

  In the case of using a solvent, the solvent to be used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, aromatic hydrocarbons such as benzene, toluene and xylene, and aliphatic hydrocarbons such as hexane and heptane. , Cycloaliphatic alicyclic hydrocarbons, chlorobenzene, dichlorobenzene and other aromatic halogenated hydrocarbons, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene Aliphatic hydrocarbons such as diethyl ether, ethers such as 1,2-dimethoxyethane, tetrahydrofuran and 1,4-dioxane, esters such as ethyl acetate and ethyl propionate, N, N-dimethylformamide, Amides such as N, N-dimethylacetamide, N-methyl-2-pyrrolidone, Methanol, ethanol, alcohols such as ethylene glycol, acetate, carboxylic acids such as propionic acid, acetonitrile and water or the like. These solvents may be used alone or as a mixture of two or more thereof.

  The reaction temperature can be set to an arbitrary temperature from −60 ° C. to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but is usually arbitrarily within a range of 5 minutes to 24 hours. Can be set.

The compound represented by the general formula (6) thus obtained and the general formula (7) [wherein G ¹ , X, R ³ and m represent the same meaning as described above. The compound represented by the general formula (1) [wherein A ¹ , A ² , A ³ is reacted with a compound inert in the reaction, if necessary, in the presence of a base. , G ¹ , G ² , X, Y, Z ^a , R ³ , m, n, and p have the same meaning as described above. This invention compound represented by this can be obtained.

  The amount of the reaction substrate may be 1 to 5 equivalents of the compound represented by the general formula (7) with respect to 1 equivalent of the compound represented by the general formula (6).

  Examples of the base to be used include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal carbonates such as sodium carbonate and potassium carbonate, alkali metal bicarbonates such as sodium bicarbonate and potassium bicarbonate, triethylamine, Organic bases such as tributylamine, N, N-dimethylaniline, pyridine, 4- (dimethylamino) pyridine, imidazole and 1,8-diazabicyclo [5,4,0] -7-undecene are represented by the general formula (6) 1-5 equivalent can be used with respect to the compound represented by these.

  In the case of using a solvent, the solvent to be used is not particularly limited as long as it does not inhibit the progress of the reaction. For example, aromatic hydrocarbons such as benzene, toluene and xylene, and aliphatic hydrocarbons such as hexane and heptane. , Cycloaliphatic alicyclic hydrocarbons, chlorobenzene, dichlorobenzene and other aromatic halogenated hydrocarbons, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene Aliphatic hydrocarbons such as diethyl ether, ethers such as 1,2-dimethoxyethane, tetrahydrofuran and 1,4-dioxane, esters such as ethyl acetate and ethyl propionate, N, N-dimethylformamide, Amides such as N, N-dimethylacetamide and N-methyl-2-pyrrolidone Acetonitrile. These solvents may be used alone or as a mixture of two or more thereof.

  The reaction temperature can be set to an arbitrary temperature from −60 ° C. to the reflux temperature of the reaction mixture, and the reaction time varies depending on the concentration of the reaction substrate and the reaction temperature, but is usually arbitrarily within the range of 5 minutes to 100 hours. Can be set.

  Generally, for example, 1 to 2 equivalents of N-chlorosuccinimide, sodium hypochlorite aqueous solution, hypochlorous acid-t-butyl ester, chlorine per 1 equivalent of the compound represented by the general formula (5) Use a halogenating agent such as gas, and use a solvent such as dichloromethane, chloroform, 1,2-dimethoxyethane, tetrahydrofuran, 1,4-dioxane, N, N-dimethylformamide, and the like. The compound represented by the general formula (6) can be obtained by performing the reaction within a range of 10 minutes to 2 hours. Next, without isolating the compound represented by the general formula (6), 1-2 equivalents of the compound represented by the general formula (7) and 1-2 equivalents of sodium carbonate, sodium bicarbonate, triethylamine, etc. It is preferable to add a base and carry out the reaction for 10 minutes to 24 hours in the range of 0 ° C. to the reflux temperature of these solvents.

  In production method A and production method B, the reaction mixture after completion of the reaction is directly concentrated or dissolved in an organic solvent, concentrated after washing with water, or poured into ice water and concentrated after extraction with an organic solvent. Of the present invention can be obtained. Moreover, when the necessity for purification arises, it can be separated and purified by any purification method such as recrystallization, column chromatograph, thin layer chromatograph, liquid chromatographic fractionation and the like.

  The compound represented by the general formula (3) used in production method A can be synthesized, for example, as follows.

  Reaction formula 1

That is, under the same conditions as in production method B, general formula (8) [wherein A ¹ , A ² , A ³ , Y, n and J ¹ represent the same meaning as described above. The compound represented by the general formula (9) [wherein A ¹ , A ² , A ³ , Y, n, J ¹ and J ² represent the same meaning as described above]. And then the compound represented by the general formula (7) [wherein G ¹ , X, R ³ and m represent the same meaning as described above. ] Is reacted with a compound represented by the general formula (3) [wherein A ¹ , A ² , A ³ , G ¹ , X, Y, R ³ , m, n and J ¹ are the same as above] Represents meaning. The compound represented by this can be obtained.

  Some of the compounds represented by the general formula (4) used in the production method A are known compounds, and some of them are commercially available. Others can also be synthesized according to the general synthesis method of substituted azoles described in the literature.

  The compound represented by the general formula (5) used in the production method B can be synthesized, for example, as follows.

  Reaction formula 2

That is, the general formula (10) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p represent the same meaning as described above. ] According to a known method described in the literature, for example, according to the method described in Journal of Medicinal Chemistry [J. Med. Chem.] 2001, 44, 2308, etc. By reacting with the salt, general formula (5) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p represent the same meaning as described above. ] Can be easily synthesized.

  The compound represented by the general formula (7) used in the production method B can be synthesized, for example, as follows.

  Reaction formula 3

That is, known general formula (11) [wherein G ¹ , X and m represent the same meaning as described above, J ³ represents a bromine atom, an iodine atom, a C ₁ -C ₄ haloalkylsulfonyloxy group (for example, trifluoromethane) Sulfonyloxy group), -B (OH) ₂ group, 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl group, -Si (OEt) ₃ group, -ZnCl, -ZnBr Represents a group or a -ZnI group. And a compound represented by the general formula (12) [wherein R ³ represents the same meaning as described above, and J ⁴ represents a halogen atom such as a bromine atom or an iodine atom or a —B (OH) ₂ group. And a compound represented by the above general cross-coupling reaction using a transition metal catalyst such as palladium described in the literature, for example, The Journal of Organic Chemistry [J. Org. Chem.] 1991, Vol. 7336, Tetrahedron Lett. 2001, Vol. 42, p. 4083, etc., by reacting according to the general formula (7) [wherein G ¹ , X, R ³ and m represent the same meaning as described above. The compound represented by this can be obtained.

  Some of the compounds represented by the general formula (12) used here are known compounds, and some of them are commercially available. Other methods are also known in the literature, such as Journal of the American Chemical Society [J. Am. Chem. Soc.] 1971, 93, 1925, Tetrahedron Letters [ Tetrahedron Lett.] 1990, 31, 1919 and 2001, 42, 4083, etc., can be easily synthesized.

In addition, the compound represented by the general formula (7) has the general formula (13) [wherein G ¹ , X, R ³ and m represent the same meaning as described above. The olefination reaction of a known carbonyl group described in the literature, for example, The Journal of Organic Chemistry [J. Org. Chem.] 1986, 51, 5252 and 1994, 59 Volume 2, page 2898, Synthesis 1991, page 29, Tetrahedron Lett. 1985, volume 26, page 5579, and the like.

  The compound represented by the general formula (8) can be synthesized, for example, as follows.

  Reaction formula 4

That is, the general formula (14) [wherein A ¹ , A ² , A ³ , Y, n and J ¹ represent the same meaning as described above. ] Is reacted with hydroxylamine or a salt thereof under the same conditions as in Reaction Scheme 2 to obtain a compound represented by the general formula (8) [wherein A ¹ , A ² , A ³ , Y, n and J ¹ represent the same meaning as described above. The compound represented by this can be obtained.

  The compound represented by the general formula (10) can be synthesized, for example, as shown in Reaction Scheme 5 or Reaction Scheme 6.

  Reaction formula 5

General formula (15) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p represent the same meaning as described above, J ⁵ represents a bromine atom, an iodine atom, a halosulfonyloxy group. (e.g., fluoro sulfonyloxy group), represents a C ₁ -C ₄ haloalkylsulfonyl group (e.g., trifluoromethanesulfonyloxy group) or an arylsulfonyloxy group (e.g., benzenesulfonyloxy group). ], For example, Bulletin of the Chemical Society of Japan [Bull. Chem. Soc. Jpn.] 1994, 67, 2329, Journal of CO using a transition metal catalyst such as palladium in the presence of a hydride source such as formic acid according to the method described in The American Chemical Society [J. Am. Chem. Soc.] 1986, 108, 452 etc. By performing the insertion reaction, the general formula (10) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p represent the same meaning as described above. The compound represented by this can be obtained.

  Reaction formula 6

Known general formula (14) [wherein A ¹ , A ² , A ³ , Y, n and J ¹ represent the same meaning as described above. And a compound of the general formula (4) [wherein G ² , Z ^a and p represent the same meaning as described above. And a compound represented by the general formula (10) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p] Represents the same meaning as described above. ] Can be easily synthesized.

  The compound represented by the general formula (13) can be synthesized, for example, as follows.

  Reaction formula 7

That is, known general formula (16) [wherein X and m represent the same meaning as described above, and G ¹ represents a benzene ring. And a known general formula (17) [wherein R ³ represents the same meaning as described above, and J ⁶ represents a leaving group such as a halogen atom, a trifluoromethanesulfonyloxy group, a 2-pyridyloxy group, and the like. Represents. Or a known general formula (18) [wherein R ³ represents the same meaning as described above. The general aromatic ring acylation reaction described in the literature, for example, Chemistry Letters [Chem. Lett.] 1990, p. 783, The Journal of Organic Chemistry [J. Org] Chem.] By reacting according to the method described in 1991, Vol. 56, p. 1963, etc., to give the general formula (13) [wherein X, R ³ and m have the same meaning as above, and G ¹ Represents a benzene ring. The compound represented by this can be obtained.

Alternatively, the known general formula (19) [wherein G ¹ , X and m represent the same meaning as described above, and J ⁷ represents a bromine atom or an iodine atom. ] After lithiation of the compound represented by the literature, for example, known general formula (20) [wherein R ³ represents the same meaning as described above, J ⁸ represents a halogen atom, a hydroxyl group, metal salts _{(e.g., -OLi, -ONa), C 1} ~C 4 alkoxy group (e.g., methoxy group, ethoxy group), di (C ₁ -C ₄ alkyl) amino group (e.g., diethylamino group), C ₁ ~ C ₄ alkoxy (C ₁ -C ₄ alkyl) amino group (for example, O, N-dimethylhydroxyamino group) or cyclic amino group (for example, piperidin-1-yl group, morpholin-4-yl group, 4-methylpiperazine) -1-yl group). Or the known compound represented by the general formula (18) [J. Am. Chem. Soc.] 1955, 77, 3657 Tetrahedron Lett. 1980, 21, 2129 and 1991, 32, 2003, US Patent Application Publication (US 5,514,816), etc., or Grignard reactant Heterocycles 1987, Vol. 25, p. 221, Synthetic Communications [Synth. Communication, formed and then reacted with a compound represented by the general formula (20) or a compound represented by the general formula (18) In accordance with the method described in 1985, 15, 1291 and 1990, 20, 1469, German Patent Application Publication (DE 19727042), etc. Reaction, general formula (13) [wherein G ¹ , X, R ³ and m represent the same meaning as described above. The compound represented by this can also be obtained.

  The compound represented by the general formula (15) can be synthesized, for example, as shown in Reaction Scheme 8.

  Reaction formula 8

That is, the general formula (21) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p represent the same meaning as described above. ], A known method described in the literature, for example, Chemical and Pharmaceutical Bulletin [Chem. Pharm. Bull.] 2000, 48, 1935, Journal of Medicinal Chemistry [J Med. Chem.] 1989, 32, 575, etc., in accordance with the general formula (22) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p represents the same meaning as described above. In accordance with a known method described in the literature, for example, the method described in Journal of Heterocyclic Chemistry [J. Heterocyclic Chem.] 1977, Vol. 14, p. diazo Te - by carrying out the halogenation reaction, the general formula (15) ^{wherein, a 1, a 2, a} 3, G 2, Y, Z a, n and p are as defined above, J ⁵ Represents a halogen atom such as a chlorine atom, a bromine atom or an iodine atom. The compound represented by this can be obtained.

  The compound represented by the general formula (21) can be synthesized, for example, as follows.

  Reaction formula 9

That is, the known general formula (23) [wherein A ¹ , A ² , A ³ , Y, n and J ¹ represent the same meaning as described above. And a compound of the general formula (4) [wherein G ² , Z ^a and p represent the same meaning as described above. And a compound represented by the general formula (21) [wherein A ¹ , A ² , A ³ , G ² , Y, Z ^a , n and p] Represents the same meaning as described above. ] Can be easily synthesized.

  In each of these reactions, after the completion of the reaction, each of the production intermediates that are the raw material compounds of production method A and production method B can be obtained by performing a general post-treatment.

  In addition, each production intermediate produced by these methods can be used as it is in the subsequent step without isolation and purification.

  Specific examples of the compound included in the present invention include compounds shown in Tables 2 to 4. However, the compounds in Tables 2 to 4 are for illustrative purposes, and the present invention is not limited thereto.

In the table, “Et” represents an ethyl group. Similarly, n-Pr and Pr-n are normal propyl groups, i-Pr and Pr-i are isopropyl groups, and c-Pr and Pr-c are Cyclopropyl group, n-Bu and Bu-n are normal butyl groups, s-Bu and Bu-s are secondary butyl groups, i-Bu and Bu-i are isobutyl groups, t-Bu and Bu-t Are tertiary butyl groups, c-Bu and Bu-c are cyclobutyl groups, n-Pen and Pen-n are normal pentyl groups, c-Pen and Pen-c are cyclopentyl groups, n-Hex and Hex- n represents a normal hexyl group, Ph represents a phenyl group,
The aromatic heterocycles represented by D3-1a to D34-3a in the table each represent the following structure,

For example, [CH ₂ (D8-3b) Cl] represents a 3-chloro-1-methylpyrazol-5-ylmethyl group, and [(D34-1c) Cl] represents 2-chloropyrimidine-5 -Represents an yl group.

  In addition, the aliphatic heterocycle represented by E3-1a in the table represents the following structure:

  Furthermore, the partially saturated heterocyclic rings represented by M7-1a and M9-1a in the table each represent the following structure,

  Furthermore, T-3 to T-5 in the table each represent the following structure.

Table 2 In the table, the numbers representing the substitution positions of the substituents (X) _m and (Z ^a ) _p correspond to the positions of the numbers described in the following structural formulas, respectively. Represents unsubstituted.

At this time, the substituent G ² in the general formulas [1] -1 to [1] -30 represents a heterocycle represented by the following G ² -1 to G ² -9, respectively.

―――――――――――――――――――――――――――――――――――――――
(X)_m                       R^Three            G²            (Z^a)_p
―――――――――――――――――――――――――――――――――――――――
3-F CF_Three           G²-5 −
3-F CF_Three           G²-8 −
4-F CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl CF_Three           G²-5 −
3-Cl CF_Three           G²-8 −
3-Cl CF_Three           G²-9 −
4-Cl CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br CF_Three           G²-5 −
3-Br CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br CF_Three           G²-8 −
3-Br CF_Three           G²-9 −
3-Br CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Br CF₂Cl G²-5 −
3-Br CF₂Cl G²-8 −
4-Br CF_Three           G²-5 −
3-I CHF₂          G²-5 3-C (O) NHCH₂CF_Three
3-I CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-I CF_Three           G²-2 4-C (O) NH₂
3-I CF_Three           G²-2 4-C (O) NHCH_Three
3-I CF_Three           G²-2 4-C (O) NHEt
3-I CF_Three           G²-2 4-C (O) NHPr-i
3-I CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-I CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-I CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-I CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-I CF_Three           G²-5 −
3-I CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-I CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-I CF_Three           G²-8 −
3-I CF_Three           G²-9 −
3-I CF_Three           G²-9 C (O) NHCH₂CF_Three
3-I CF₂Cl G²-5 −
3-I CF₂Cl G²-8 −
3-I CF₂Cl G²-9 −
3-I CF₂Br G²-8 −
3-I CF₂CHF₂       G²-9 −
4-I CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CH_Three                      CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Et CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Pr-i CF_Three           G²-5 −
3-Bu-t CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three                      CHF₂          G²-8 −
3-CF_Three                      CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three           G²-2 4-C (O) NH₂
3-CF_Three                      CF_Three           G²-2 4-C (O) NHCH_Three
3-CF_Three                      CF_Three           G²-2 4-C (O) NHEt
3-CF_Three                      CF_Three           G²-2 4-C (O) NHPr-i
3-CF_Three                      CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-CF_Three                      CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three           G²-5 −
3-CF_Three                      CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-CF_Three                      CF_Three           G²-8 −
3-CF_Three                      CF_Three           G²-9 −
3-CF_Three                      CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three                      CF₂Cl G²-5 −
3-CF_Three                      CF₂Cl G²-8 −
3-CF_Three                      CF₂Cl G²-9 −
3-CF_Three                      CF₂Br G²-9 −
3-CF_Three                      CF₂CHF₂       G²-9 C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CHF₂          G²-2 3-C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three           G²-2 4-C (O) NH₂
3-CF₂CF_Three                   CF_Three           G²-2 4-C (O) NHCH_Three
3-CF₂CF_Three                   CF_Three           G²-2 4-C (O) NHEt
3-CF₂CF_Three                   CF_Three           G²-2 4-C (O) NHPr-i
3-CF₂CF_Three                   CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-CF₂CF_Three                   CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three           G²-5 −
3-CF₂CF_Three                   CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF_Three           G²-8 −
3-CF₂CF_Three                   CF_Three           G²-9 −
3-CF₂CF_Three                   CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF₂Cl G²-5 −
3-CF₂CF_Three                   CF₂Cl G²-8 −
3-CF₂CF_Three                   CF₂Cl G²-9 −
3-CF₂CF_Three                   CF₂Br G²-2 4-C (O) NHCH₂CF_Three
3-CF₂CF_Three                   CF₂CHF₂       G²-5 −
3-CF₂CF₂CF_Three                CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF₂CF₂CF_Three                CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF₂CF₂CF_Three                CF_Three           G²-5 −
3-CF₂CF₂CF_Three                CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF₂CF₂CF_Three                CF_Three           G²-8 −
3-CF₂CF₂CF_Three                CF_Three           G²-9 −
3-CF₂CF₂CF_Three                CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF₂CF₂CF_Three                CF₂Cl G²-5 −
3-CF₂CF₂CF_Three                CF₂Cl G²-8 −
3-CF (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF (CF_Three)₂                 CF_Three           G²-5 −
3-CF (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF (CF_Three)₂                 CF_Three           G²-8 −
3-CF (CF_Three)₂                 CF_Three           G²-9 −
3-CF (CF_Three)₂                 CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF (CF_Three)₂                 CF₂Cl G²-5 −
3-CF (CF_Three)₂                 CF₂Cl G²-8 −
3-CF₂CF₂CF₂CF_Three             CF_Three           G²-5 −
3-CF₂CF₂CF₂CF_Three             CF_Three           G²-8 −
3-CF₂CF₂CF₂CF_Three             CF_Three           G²-9 −
3-CH₂OCH₂CF_Three               CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-C (CF_Three)₂OH CF_Three           G²-5 −
3-C (CF_Three)₂OH CF_Three           G²-8 −
3-C (CF_Three)₂OH CF_Three           G²-9 −
3-C (CF_Three)₂OCH_Three              CF_Three           G²-5 −
3-C (CF_Three)₂OCH_Three              CF_Three           G²-8 −
3-C (CF_Three)₂OCH_Three              CF_Three           G²-9 −
3-CH₂SCH_Three                  CF_Three           G²-8 −
3-CH₂SEt CF_Three           G²-9 −
3-CH₂SPr-i CF_Three           G²-9 C (O) NHCH₂CF_Three 
3-CH₂SPr-c CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CH₂SCF_Three                  CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CH₂S (O) CF_Three               CF_Three           G²-5 −
3-CH₂SO₂CF_Three                CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CH₂SCH₂CF_Three               CF_Three           G²-8 −
3- (T-3) CF_Three           G²-9 −
3- (T-4) CF_Three           G²-9 C (O) NHCH₂CF_Three 
3- (T-5) CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-OCHF₂                    CF_Three           G²-2 4-C (O) NHCH₂CF_Three
4-OCHF₂                    CF_Three           G²-5 −
3-OCF_Three                     CF_Three           G²-5 −
3-OCF_Three                     CF_Three           G²-8 −
3-OCF_Three                     CF_Three           G²-9 −
3-OCF_Three                     CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3-OCF₂Br CF_Three           G²-5 −
3-OCF₂Br CF_Three           G²-8 −
3-OCF₂Br CF_Three           G²-9 −
3-OCF₂Br CF₂Cl G²-8 −
3-OCH₂CH₂Cl CF_Three           G²-9 −
3-OCH₂CF_Three                  CF_Three           G²-9 C (O) NHCH₂CF_Three
3-OCF₂CHF₂                 CF_Three           G²-5 −
3-OCF₂CHF₂                 CF_Three           G²-8 −
3-OCF₂CHF₂                 CF_Three           G²-9 −
3-OCF₂CHFCl CF_Three           G²-5 −
3-OCF₂CHFCl CF_Three           G²-8 −
3-OCF₂CHFCl CF_Three           G²-9 −
3-OCF₂CHFBr CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-OCF₂CF₂Br CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-OCF₂CFCl₂                CF_Three           G²-5 −
3-OCF₂CCl_Three                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-OCH₂CF₂CHF₂              CF_Three           G²-8 −
3-OCF₂CHFCF_Three               CF_Three           G²-5 −
3-OCF₂CHFCF_Three               CF_Three           G²-8 −
3-OCF₂CHFCF_Three               CF_Three           G²-9 −
3-OCH (CF_Three)₂                CF_Three           G²-9 −
3-OCF₂CFBrCF_Three              CF_Three           G²-9 C (O) NHCH₂CF_Three 
3-OCF₂CHFOCF_Three              CF_Three           G²-5 −
3-OCF₂CHFOCF_Three              CF_Three           G²-8 −
3-OCF₂CHFOCF_Three              CF_Three           G²-9 −
3-OCF₂CHFOCF₂CF₂CF_Three        CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-OCH₂CH = CF₂               CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-OCH₂CF = CF₂               CF_Three           G²-5 −
3-OCH₂CH = CCl₂              CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-OCH₂CCl = CCl₂             CF_Three           G²-8 −
3-OSO₂CHCl₂                CF_Three           G²-9 −
3-OSO₂CF_Three                  CF_Three           G²-9 C (O) NHCH₂CF_Three 
3-OSO₂CH₂CF_Three               CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-OPh CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-SCH_Three                     CF_Three           G²-5 −
3-S (O) CH_Three                  CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-SO₂CH_Three                   CF_Three           G²-8 −
3-SCH₂F CF_Three           G²-9 −
3-S (O) CH₂F CF_Three           G²-9 C (O) NHCH₂CF_Three 
3-SO₂CH₂F CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-SCHF₂                    CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-S (O) CHF₂                 CF_Three           G²-5 −
3-SO₂CHF₂                  CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-SCF_Three                     CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-SCF_Three                     CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-SCF_Three                     CF_Three           G²-5 −
3-SCF_Three                     CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-SCF_Three                     CF_Three           G²-8 −
3-SCF_Three                     CF_Three           G²-9 −
3-SCF_Three                     CF_Three           G²-9 C (O) NHCH₂CF_Three
3-SCF_Three                     CF₂Cl G²-5 −
3-SCF_Three                     CF₂Cl G²-8 −
3-S (O) CF_Three                  CF_Three           G²-8 −
3-SO₂CF_Three                   CF_Three           G²-9 −
3-SCF₂Cl CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-SCF₂Cl CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-SCF₂Cl CF_Three           G²-5 −
3-SCF₂Cl CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-SCF₂Cl CF_Three           G²-8 −
3-SCF₂Cl CF_Three           G²-9 −
3-SCF₂Cl CF_Three           G²-9 C (O) NHCH₂CF_Three
3-SCF₂Cl CF₂Cl G²-5 −
3-SCF₂Cl CF₂Cl G²-8 −
3-S (O) CF₂Cl CF_Three           G²-9 C (O) NHCH₂CF_Three
3-SO₂CF₂Cl CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-SCF₂Br CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-SCF₂Br CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-SCF₂Br CF_Three           G²-5 −
3-SCF₂Br CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-SCF₂Br CF_Three           G²-8 −
3-SCF₂Br CF_Three           G²-9 −
3-SCF₂Br CF_Three           G²-9 C (O) NHCH₂CF_Three
3-SCF₂Br CF₂Cl G²-5 −
3-SCF₂Br CF₂Cl G²-8 −
3-S (O) CF₂Br CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-SO₂CF₂Br CF_Three           G²-5 −
3-SCH₂CF_Three                  CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-SCF₂CHF₂                 CF_Three           G²-8 −
3-SCF₂CHFCl CF_Three           G²-9 −
3-SCF₂CF_Three                  CF_Three           G²-9 C (O) NHCH₂CF_Three
3-SCF₂CF₂Br CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-SCF₂CHFCF_Three               CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-SCF₂CF₂CF_Three               CF_Three           G²-5 −
3-SO₂NHCH_Three                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-SO₂N (CH_Three)₂               CF_Three           G²-8 −
3-S (Ph-4-Cl) CF_Three           G²-9 −
3-SF_Five                      CHF₂          G²-9 C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three           G²-2 4-C (O) NH₂
3-SF_Five                      CF_Three           G²-2 4-C (O) NHCH_Three
3-SF_Five                      CF_Three           G²-2 4-C (O) NHEt
3-SF_Five                      CF_Three           G²-2 4-C (O) NHPr-i
3-SF_Five                      CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-SF_Five                      CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three           G²-5 −
3-SF_Five                      CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-SF_Five                      CF_Three           G²-8 −
3-SF_Five                      CF_Three           G²-9 −
3-SF_Five                      CF_Three           G²-9 C (O) NHCH₂CF_Three
3-SF_Five                      CF₂Cl G²-5 −
3-SF_Five                      CF₂Cl G²-8 −
3-SF_Five                      CF₂Cl G²-9 −
3-SF_Five                      CF₂Br G²-2 3-C (O) NHCH₂CF_Three
3-SF_Five                      CF₂CHF₂       G²-2 4-C (O) NHCH₂CF_Three
3-NO₂                      CF_Three           G²-5 −
3-NHSO₂CF_Three                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Si (CH_Three)_Three                 CF_Three           G²-8 −
3-CN CF_Three           G²-9 −
3-C (O) NH₂                  CF_Three           G²-9 C (O) NHCH₂CF_Three
3-C (S) NH₂                  CF_Three           G²-2 3-C (O) NHCH₂CF_Three
2,3-F₂                     CF_Three           G²-2 4-C (O) NHCH₂CF_Three
2,4-F₂                     CF_Three           G²-5 −
2,5-F₂                     CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,4-F₂                     CF_Three           G²-5 −
3,4-F₂                     CF_Three           G²-8 −
3,5-F₂                     CF_Three           G²-5 −
3,5-F₂                     CF_Three           G²-8 −
2-F-3-Cl CF_Three           G²-8 −
3-Cl-4-F CHF₂          G²-9 −
3-Cl-4-F CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three           G²-2 4-C (O) NH₂
3-Cl-4-F CF_Three           G²-2 4-C (O) NHCH_Three
3-Cl-4-F CF_Three           G²-2 4-C (O) NHEt
3-Cl-4-F CF_Three           G²-2 4-C (O) NHPr-i
3-Cl-4-F CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-4-F CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three           G²-5 −
3-Cl-4-F CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Cl-4-F CF_Three           G²-8 −
3-Cl-4-F CF_Three           G²-9 −
3-Cl-4-F CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-4-F CF₂Cl G²-5 −
3-Cl-4-F CF₂Cl G²-8 −
3-Cl-4-F CF₂Cl G²-9 −
3-Cl-4-F CF₂Br G²-9 C (O) NHCH₂CF_Three
3-Cl-4-F CF₂CHF₂       G²-2 3-C (O) NHCH₂CF_Three
2-F-4-Cl CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-F-4-Cl CF_Three           G²-5 −
3-F-5-Cl CHF₂          G²-5 3-C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three           G²-2 4-C (O) NH₂
3-F-5-Cl CF_Three           G²-2 4-C (O) NHCH_Three
3-F-5-Cl CF_Three           G²-2 4-C (O) NHEt
3-F-5-Cl CF_Three           G²-2 4-C (O) NHPr-i
3-F-5-Cl CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-F-5-Cl CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three           G²-5 −
3-F-5-Cl CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-F-5-Cl CF_Three           G²-8 −
3-F-5-Cl CF_Three           G²-9 −
3-F-5-Cl CF_Three           G²-9 C (O) NHCH₂CF_Three
3-F-5-Cl CF₂Cl G²-5 −
3-F-5-Cl CF₂Cl G²-8 −
3-F-5-Cl CF₂Cl G²-9 −
3-F-5-Cl CF₂Br G²-8 −
3-F-5-Cl CF₂CHF₂       G²-9 −
2,3-Cl₂                    CF_Three           G²-9 C (O) NHCH₂CF_Three
2,5-Cl₂                    CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,4-Cl₂                    CHF₂          G²-2 4-C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three           G²-2 4-C (O) NH₂
3,4-Cl₂                    CF_Three           G²-2 4-C (O) NHCH_Three
3,4-Cl₂                    CF_Three           G²-2 4-C (O) NHEt
3,4-Cl₂                    CF_Three           G²-2 4-C (O) NHPr-i
3,4-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,4-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three           G²-5 −
3,4-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,4-Cl₂                    CF_Three           G²-8 −
3,4-Cl₂                    CF_Three           G²-9 −
3,4-Cl₂                    CF_Three           G²-9 C (O) NHCH₂CF_Three
3,4-Cl₂                    CF₂Cl G²-5 −
3,4-Cl₂                    CF₂Cl G²-8 −
3,4-Cl₂                    CF₂Cl G²-9 −
3,4-Cl₂                    CF₂Br G²-5 −
3,4-Cl₂                    CF₂CHF₂       G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CH_Three           G²-8 −
3,5-Cl₂                    Et G²-9 −
3,5-Cl₂                    n-Pr G²-9 C (O) NHCH₂CF_Three 
3,5-Cl₂                    i-Pr G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    c-Pr G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CH₂F G²-5 −
3,5-Cl₂                    CH₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CH₂Br G²-8 −
3,5-Cl₂                    CH₂I G²-9 −
3,5-Cl₂                    CHF₂          G²-5 −
3,5-Cl₂                    CHF₂          G²-8 −
3,5-Cl₂                    CHF₂          G²-9 −
3,5-Cl₂                    CHFCl G²-5 −
3,5-Cl₂                    CHFCl G²-8 −
3,5-Cl₂                    CHCl₂         G²-5 −
3,5-Cl₂                    CHCl₂         G²-8 −
3,5-Cl₂                    CHFBr G²-5 −
3,5-Cl₂                    CHFBr G²-8 −
3,5-Cl₂                    CF_Three           G²-1 −
3,5-Cl₂                    CF_Three           G²-1 2-Cl
3,5-Cl₂                    CF_Three           G²-1 2-Br
3,5-Cl₂                    CF_Three           G²-1 2-SCN
3,5-Cl₂                    CF_Three           G²-1 2-CN
3,5-Cl₂                    CF_Three           G²-1 2-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-1 3-OCH_Three
3,5-Cl₂                    CF_Three           G²-1 3-NO₂
3,5-Cl₂                    CF_Three           G²-1 3-CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-1 3-CN
3,5-Cl₂                    CF_Three           G²-1 3-C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHCH_Three
3,5-Cl₂                    CF_Three           G²-1 3-C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHEt
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHPr-n
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHPr-i
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHPr-c
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHCH₂CN
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three           G²-1 3-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three           G²-1 3-C (= NH) NH₂
3,5-Cl₂                    CF_Three           G²-2 −
3,5-Cl₂                    CF_Three           G²-2 3-NO₂
3,5-Cl₂                    CF_Three           G²-2 3-CN
3,5-Cl₂                    CF_Three           G²-2 3-C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHCH_Three
3,5-Cl₂                    CF_Three           G²-2 3-C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHEt
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHPr-n
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHPr-i
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHPr-c
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHCH₂CN
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three           G²-2 3-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three           G²-2 3- (D32-1a)
3,5-Cl₂                    CF_Three           G²-2 4-SCF_Three
3,5-Cl₂                    CF_Three           G²-2 4-S (O) CF_Three
3,5-Cl₂                    CF_Three           G²-2 4-SO₂CF_Three
3,5-Cl₂                    CF_Three           G²-2 4-NO₂
3,5-Cl₂                    CF_Three           G²-2 4-CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-CN
3,5-Cl₂                    CF_Three           G²-2 4-C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N (CH_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHEt
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHPr-n
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHPr-i
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHPr-c
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N (CH₂CF_Three) C (O) CH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N (CH₂OCH_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N (CH₂OEt) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N (CH₂OCH₂CF_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NH (E3-1a)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂CN
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH (CH_Three) C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH (CH_Three) Ph (R)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂(D8-3a) CH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂(D8-3b) Cl
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂(D10-2a)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) Et] CH₂(D10-2a)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N (CH₂CN) CH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) Et] CH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHN (CH_Three) Ph
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHN (CH_Three) (D34-1a)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHCH = NOEt
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) Et] C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) OCH_Three] C (O) OEt
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHC (O) OPr-i
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) OCH_Three] C (O) OPr-i
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NHC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) CH_Three] (Ph-4-F)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NH (Ph-2,4-F₂)
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) CH_Three] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) Et] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) Pr-i] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) OCH_Three] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) CH_Three] (D34-1c) Br
3,5-Cl₂                    CF_Three           G²-2 4-C (O) N [C (O) Et] (D34-1c) Br
3,5-Cl₂                    CF_Three           G²-2 4-C (O) NH (D34-3a)
3,5-Cl₂                    CF_Three           G²-2 4-C (S) NH₂
3,5-Cl₂                    CF_Three           G²-2 4-C (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-2 5-Cl
3,5-Cl₂                    CF_Three           G²-2 5-CH_Three
3,5-Cl₂                    CF_Three           G²-2 5-CF_Three
3,5-Cl₂                    CF_Three           G²-2 5-OCH_Three
3,5-Cl₂                    CF_Three           G²-2 5-SCH_Three
3,5-Cl₂                    CF_Three           G²-2 5-S (O) CH_Three
3,5-Cl₂                    CF_Three           G²-2 5-SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-2 5-CN
3,5-Cl₂                    CF_Three           G²-2 3,5- (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-2 3-CH_Three-4-CN
3,5-Cl₂                    CF_Three           G²-3 −
3,5-Cl₂                    CF_Three           G²-3 2-CH_Three
3,5-Cl₂                    CF_Three           G²-3 2-SCH_Three
3,5-Cl₂                    CF_Three           G²-3 4-NO₂
3,5-Cl₂                    CF_Three           G²-3 4-C (O) OEt
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHCH_Three
3,5-Cl₂                    CF_Three           G²-3 4-C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHEt
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHPr-n
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHPr-i
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHPr-c
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHCH₂CN
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three           G²-3 4-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three           G²-3 4-C (S) NH₂
3,5-Cl₂                    CF_Three           G²-3 4-C (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-3 5-CN
3,5-Cl₂                    CF_Three           G²-3 5-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-3 4,5-Cl₂
3,5-Cl₂                    CF_Three           G²-3 2-CH_Three-4-NO₂
3,5-Cl₂                    CF_Three           G²-3 4-NO₂-5-CH_Three
3,5-Cl₂                    CF_Three           G²-3 2-CH_Three-4-CN
3,5-Cl₂                    CF_Three           G²-4 −
3,5-Cl₂                    CF_Three           G²-4 4-CH₂SCH_Three
3,5-Cl₂                    CF_Three           G²-4 4-CH₂S (O) CH_Three
3,5-Cl₂                    CF_Three           G²-4 4-CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-4 4-CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-4 4-CN
3,5-Cl₂                    CF_Three           G²-4 4-C (O) OEt
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHCH_Three
3,5-Cl₂                    CF_Three           G²-4 4-C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHEt
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHPr-n
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHPr-i
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHPr-c
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHCH₂CN
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three           G²-4 4-C (S) NH₂
3,5-Cl₂                    CF_Three           G²-4 4-C (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-4 5-Cl
3,5-Cl₂                    CF_Three           G²-4 5-CH_Three
3,5-Cl₂                    CF_Three           G²-4 5-SCH_Three
3,5-Cl₂                    CF_Three           G²-4 5-C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-4 5-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-4 4-CN-5-Cl
3,5-Cl₂                    CF_Three           G²-4 4-C (O) NH₂-5-CH_Three
3,5-Cl₂                    CF_Three           G²-5 −
3,5-Cl₂                    CF_Three           G²-5 3-Cl
3,5-Cl₂                    CF_Three           G²-5 3-OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-OCH₂C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-OCH₂C (O) NH₂
3,5-Cl₂                    CF_Three           G²-5 3-OP (S) (OEt)₂
3,5-Cl₂                    CF_Three           G²-5 3-SCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-5 3-NO₂
3,5-Cl₂                    CF_Three           G²-5 3-NH₂
3,5-Cl₂                    CF_Three           G²-5 3-NHCHO
3,5-Cl₂                    CF_Three           G²-5 3-NHC (O) CH_Three
3,5-Cl₂                    CF_Three           G²-5 3-NHC (O) CF_Three
3,5-Cl₂                    CF_Three           G²-5 3-NHC (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-CHO
3,5-Cl₂                    CF_Three           G²-5 3-C (O) CH_Three
3,5-Cl₂                    CF_Three           G²-5 3-CH = NOH
3,5-Cl₂                    CF_Three           G²-5 3-CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (CH_Three) = NOH
3,5-Cl₂                    CF_Three           G²-5 3-C (CH_Three) = NOCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-CN
3,5-Cl₂                    CF_Three           G²-5 3-C (O) OH
3,5-Cl₂                    CF_Three           G²-5 3-C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N (CH_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHEt
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHPr-n
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHPr-i
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHPr-c
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N (CH₂CF_Three) C (O) CH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N (CH₂OCH_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N (CH₂OEt) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N (CH₂OCH₂CF_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NH (E3-1a)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂CN
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH (CH_Three) C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH (CH_Three) Ph (R)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂(D8-3a) CH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂(D8-3b) Cl
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂(D10-2a)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) Et] CH₂(D10-2a)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N (CH₂CN) CH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) Et] CH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHN (CH_Three) Ph
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHN (CH_Three) (D34-1a)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHCH = NOEt
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) Et] C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) OCH_Three] C (O) OEt
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHC (O) OPr-i
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) OCH_Three] C (O) OPr-i
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NHC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) CH_Three] (Ph-4-F)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NH (Ph-2,4-F₂)
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) CH_Three] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) Et] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) Pr-i] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) OCH_Three] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) CH_Three] (D34-1c) Br
3,5-Cl₂                    CF_Three           G²-5 3-C (O) N [C (O) Et] (D34-1c) Br
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NH (D34-3a)
3,5-Cl₂                    CF_Three           G²-5 3-C (S) NH₂
3,5-Cl₂                    CF_Three           G²-5 3-C (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-5 3-P (O) (OEt)₂
3,5-Cl₂                    CF_Three           G²-5 3- (D5-1c) Et
3,5-Cl₂                    CF_Three           G²-5 3- (D32-1a)
3,5-Cl₂                    CF_Three           G²-5 5-Cl
3,5-Cl₂                    CF_Three           G²-5 5-CH_Three
3,5-Cl₂                    CF_Three           G²-5 5-CH₂OCH_Three
3,5-Cl₂                    CF_Three           G²-5 5-OCH_Three
3,5-Cl₂                    CF_Three           G²-5 5-SCH_Three
3,5-Cl₂                    CF_Three           G²-5 5-NH₂
3,5-Cl₂                    CF_Three           G²-5 5-CHO
3,5-Cl₂                    CF_Three           G²-5 5-C (O) CH_Three
3,5-Cl₂                    CF_Three           G²-5 5-CH = NOH
3,5-Cl₂                    CF_Three           G²-5 5-CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-5 5-C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-5 5-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-5 5- (D22-1a)
3,5-Cl₂                    CF_Three           G²-5 3,5-Br₂
3,5-Cl₂                    CF_Three           G²-5 3-CH_Three-5-Cl
3,5-Cl₂                    CF_Three           G²-5 3,5- (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-5 3-NHC (O) OCH_Three-5-CH_Three
3,5-Cl₂                    CF_Three           G²-5 3-CN-5-CH_Three
3,5-Cl₂                    CF_Three           G²-5 3-C (O) NH₂-5-CH_Three
3,5-Cl₂                    CF_Three           G²-6 −
3,5-Cl₂                    CF_Three           G²-6 4-OCH_Three
3,5-Cl₂                    CF_Three           G²-6 4-OC (O) CH_Three
3,5-Cl₂                    CF_Three           G²-6 4-SCH_Three
3,5-Cl₂                    CF_Three           G²-6 4-SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-6 4-SC (O) CH_Three
3,5-Cl₂                    CF_Three           G²-6 4-NO₂
3,5-Cl₂                    CF_Three           G²-6 4-NHCH_Three
3,5-Cl₂                    CF_Three           G²-6 4-CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-6 4-CN
3,5-Cl₂                    CF_Three           G²-6 4-C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NH₂
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHCH_Three
3,5-Cl₂                    CF_Three           G²-6 4-C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHEt
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHPr-n
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHPr-i
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHPr-c
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHCH₂CN
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three           G²-6 4-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three           G²-6 4-C (S) NH₂
3,5-Cl₂                    CF_Three           G²-6 4-C (S) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-6 4-F-5-OCH_Three
3,5-Cl₂                    CF_Three           G²-6 4-F-5-SCH_Three
3,5-Cl₂                    CF_Three           G²-6 4-F-5-S (O) CH_Three
3,5-Cl₂                    CF_Three           G²-6 4-F-5-SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-6 4-Br-5-NO₂
3,5-Cl₂                    CF_Three           G²-6 4-OCH_Three-5-NO₂
3,5-Cl₂                    CF_Three           G²-7 −
3,5-Cl₂                    CF_Three           G²-7 2-CH_Three
3,5-Cl₂                    CF_Three           G²-7 2-CH₂OCH_Three
3,5-Cl₂                    CF_Three           G²-7 2-CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-8 −
3,5-Cl₂                    CF_Three           G²-8 Cl
3,5-Cl₂                    CF_Three           G²-8 Br
3,5-Cl₂                    CF_Three           G²-8 I
3,5-Cl₂                    CF_Three           G²-8 CH_Three
3,5-Cl₂                    CF_Three           G²-8 CH₂OEt
3,5-Cl₂                    CF_Three           G²-8 CH₂SCH_Three
3,5-Cl₂                    CF_Three           G²-8 CH₂S (O) CH_Three
3,5-Cl₂                    CF_Three           G²-8 CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-8 CH₂CN
3,5-Cl₂                    CF_Three           G²-8 OCH_Three
3,5-Cl₂                    CF_Three           G²-8 SCH_Three
3,5-Cl₂                    CF_Three           G²-8 S (O) CH_Three
3,5-Cl₂                    CF_Three           G²-8 SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-8 NHCH_Three
3,5-Cl₂                    CF_Three           G²-8 N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-8 CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-8 CN
3,5-Cl₂                    CF_Three           G²-9 −
3,5-Cl₂                    CF_Three           G²-9 CH₂OCH_Three
3,5-Cl₂                    CF_Three           G²-9 CH₂SCH_Three
3,5-Cl₂                    CF_Three           G²-9 CH₂S (O) CH_Three
3,5-Cl₂                    CF_Three           G²-9 CH₂SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-9 CH₂SC (= NH) NH₂
3,5-Cl₂                    CF_Three           G²-9 CH₂NH₂
3,5-Cl₂                    CF_Three           G²-9 OCH_Three
3,5-Cl₂                    CF_Three           G²-9 SCH_Three
3,5-Cl₂                    CF_Three           G²-9 S (O) CH_Three
3,5-Cl₂                    CF_Three           G²-9 SO₂CH_Three
3,5-Cl₂                    CF_Three           G²-9 CH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) CH_Three
3,5-Cl₂                    CF_Three           G²-9 CN
3,5-Cl₂                    CF_Three           G²-9 C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) NH₂
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) N (CH_Three)₂
3,5-Cl₂                    CF_Three           G²-9 C (O) N (CH_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) NHEt
3,5-Cl₂                    CF_Three           G²-9 C (O) NHPr-n
3,5-Cl₂                    CF_Three           G²-9 C (O) NHPr-i
3,5-Cl₂                    CF_Three           G²-9 C (O) NHPr-c
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂CH₂F
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) N (CH₂CF_Three) C (O) CH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) N (CH₂OCH_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) N (CH₂OEt) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂OCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) N (CH₂OCH₂CF_Three) C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) NH (E3-1a)
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂CN
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH (CH_Three) C (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂C≡CH
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH (CH_Three) Ph (R)
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂(D8-3a) CH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂(D8-3b) Cl
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂(D10-2a)
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) Et] CH₂(D10-2a)
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-9 C (O) N (CH₂CN) CH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) Et] CH₂(D32-1a)
3,5-Cl₂                    CF_Three           G²-9 C (O) NHN (CH_Three) Ph
3,5-Cl₂                    CF_Three           G²-9 C (O) NHN (CH_Three) (D34-1a)
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH = NOCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) NHCH = NOEt
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) Et] C (O) OCH_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) OCH_Three] C (O) OEt
3,5-Cl₂                    CF_Three           G²-9 C (O) NHC (O) OPr-i
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) OCH_Three] C (O) OPr-i
3,5-Cl₂                    CF_Three           G²-9 C (O) NHC (O) NHCH₂CF_Three
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) CH_Three] (Ph-4-F)
3,5-Cl₂                    CF_Three           G²-9 C (O) NH (Ph-2,4-F₂)
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) CH_Three] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) Et] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) Pr-i] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) OCH_Three] (D34-1c) Cl
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) CH_Three] (D34-1c) Br
3,5-Cl₂                    CF_Three           G²-9 C (O) N [C (O) Et] (D34-1c) Br
3,5-Cl₂                    CF_Three           G²-9 C (O) NH (D34-3a)
3,5-Cl₂                    CF_Three           G²-9 C (S) NH₂
3,5-Cl₂                    CF_Three           G²-9 C (S) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NH₂
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) N (CH_Three)₂
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHEt
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHPr-n
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHPr-i
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHPr-c
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHCH₂CN
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF₂Cl G²-2 3-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NH₂
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) N (CH_Three)₂
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHEt
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHPr-n
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHPr-i
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHPr-c
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHCH₂CN
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF₂Cl G²-2 4-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF₂Cl G²-2 4-C (S) NH₂
3,5-Cl₂                    CF₂Cl G²-2 4-C (S) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NH₂
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) N (CH_Three)₂
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHEt
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHPr-n
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHPr-i
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHPr-c
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHCH₂CN
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF₂Cl G²-3 4-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF₂Cl G²-4 −
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NH₂
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) N (CH_Three)₂
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHEt
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHPr-n
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHPr-i
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHPr-c
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHCH₂CN
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF₂Cl G²-4 4-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF₂Cl G²-5 −
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NH₂
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) N (CH_Three)₂
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHEt
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHPr-n
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHPr-i
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHPr-c
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHCH₂CN
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF₂Cl G²-5 3-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF₂Cl G²-5 3-C (S) NH₂
3,5-Cl₂                    CF₂Cl G²-5 3-C (S) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NH₂
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) N (CH_Three)₂
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHEt
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHPr-n
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHPr-i
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHPr-c
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHCH₂CN
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF₂Cl G²-6 4-C (O) NHCH₂C≡CH
3,5-Cl₂                    CF₂Cl G²-7 −
3,5-Cl₂                    CF₂Cl G²-8 −
3,5-Cl₂                    CF₂Cl G²-8 CH_Three
3,5-Cl₂                    CF₂Cl G²-9 −
3,5-Cl₂                    CF₂Cl G²-9 C (O) NH₂
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHCH_Three
3,5-Cl₂                    CF₂Cl G²-9 C (O) N (CH_Three)₂
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHEt
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHPr-n
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHPr-i
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHPr-c
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHCH₂CH₂F
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHCH₂CH₂Cl
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHCH₂CN
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHCH₂CH = CH₂
3,5-Cl₂                    CF₂Cl G²-9 C (O) NHCH₂C≡CH
3,5-Cl₂                    CF₂Cl G²-9 C (S) NH₂
3,5-Cl₂                    CF₂Cl G²-9 C (S) NHCH₂CF_Three
3,5-Cl₂                    CFCl₂         G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂                    CCl_Three          G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂Br G²-5 −
3,5-Cl₂                    CF₂Br G²-8 −
3,5-Cl₂                    CF₂Br G²-9 −
3,5-Cl₂                    CFClBr G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CFBr₂         G²-5 −
3,5-Cl₂                    CF₂I G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CHF₂       G²-5 −
3,5-Cl₂                    CF₂CHF₂       G²-8 −
3,5-Cl₂                    CF₂CHF₂       G²-9 −
3,5-Cl₂                    CF₂CF_Three        G²-5 −
3,5-Cl₂                    CF₂CF_Three        G²-8 −
3,5-Cl₂                    CF₂CF₂Cl G²-8 −
3,5-Cl₂                    CFClCF_Three       G²-9 −
3,5-Cl₂                    CFClCF₂Cl G²-9 C (O) NHCH₂CF_Three 
3,5-Cl₂                    CF₂CF₂Br G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CFBrCF_Three       G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CHFCF_Three     G²-5 −
3,5-Cl₂                    CF₂CF₂CF_Three     G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF (CF_Three)₂      G²-8 −
3,5-Cl₂                    CF₂CFClCF₂Cl G²-9 −
3,5-Cl₂                    CF₂CFBrCF₂Cl G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂                    CH₂OCH₂CF_Three    G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CH₂OCH (CF_Three)₂  G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂OCH_Three       G²-5 −
3,5-Cl₂                    CF₂OCH_Three       G²-8 −
3,5-Cl₂                    CH₂SCF_Three       G²-5 −
3,5-Cl₂                    CH₂CH₂SCF_Three    G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂SCH_Three       G²-8 −
3,5-Cl₂                    CF₂SPr-i G²-9 −
3,5-Cl₂                    CF₂SCH₂Ph G²-9 C (O) NHCH₂CF_Three 
3,5-Cl₂                    CF₂SPh G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂CN G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂C (O) OCH_Three   G²-5 −
3,5-Cl₂                    CF₂C (O) NH₂    G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    CF₂SO₂N (CH_Three)₂          G²-8 −
3,5-Cl₂                    T-3 G²-5 −
3,5-Cl₂                    T-3 G²-8 −
3,5-Cl₂                    T-4 G²-9 −
3,5-Cl₂                    T-5 G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂                    Ph G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    Ph-2-F G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂                    Ph-3-F G²-5 −
3,5-Cl₂                    Ph-4-F G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂                    Ph-2-Cl G²-8 −
3,5-Cl₂                    Ph-3-Cl G²-9 −
3,5-Cl₂                    Ph-4-Cl G²-9 C (O) NHCH₂CF_Three
3-Br-4-F CHF₂          G²-2 3-C (O) NHCH₂CF_Three
3-Br-4-F CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br-4-F CF_Three           G²-2 4-C (O) NH₂
3-Br-4-F CF_Three           G²-2 4-C (O) NHCH_Three
3-Br-4-F CF_Three           G²-2 4-C (O) NHEt
3-Br-4-F CF_Three           G²-2 4-C (O) NHPr-i
3-Br-4-F CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Br-4-F CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-4-F CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Br-4-F CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Br-4-F CF_Three           G²-5 −
3-Br-4-F CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-4-F CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Br-4-F CF_Three           G²-8 −
3-Br-4-F CF_Three           G²-9 −
3-Br-4-F CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Br-4-F CF₂Cl G²-5 −
3-Br-4-F CF₂Cl G²-8 −
3-Br-4-F CF₂Cl G²-9 −
3-Br-4-F CF₂Br G²-2 4-C (O) NHCH₂CF_Three
3-Br-4-F CF₂CHF₂       G²-5 −
2-F-4-Br CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-4-Br CF_Three           G²-8 −
2-F-5-Br CF_Three           G²-9 −
3-F-5-Br CHF₂          G²-9 C (O) NHCH₂CF_Three
3-F-5-Br CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-F-5-Br CF_Three           G²-2 4-C (O) NH₂
3-F-5-Br CF_Three           G²-2 4-C (O) NHCH_Three
3-F-5-Br CF_Three           G²-2 4-C (O) NHEt
3-F-5-Br CF_Three           G²-2 4-C (O) NHPr-i
3-F-5-Br CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-F-5-Br CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-F-5-Br CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-F-5-Br CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-F-5-Br CF_Three           G²-5 −
3-F-5-Br CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-5-Br CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-F-5-Br CF_Three           G²-8 −
3-F-5-Br CF_Three           G²-9 −
3-F-5-Br CF_Three           G²-9 C (O) NHCH₂CF_Three
3-F-5-Br CF₂Cl G²-5 −
3-F-5-Br CF₂Cl G²-8 −
3-F-5-Br CF₂Cl G²-9 −
3-F-5-Br CF₂Br G²-2 3-C (O) NHCH₂CF_Three
3-F-5-Br CF₂CHF₂       G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CHF₂          G²-5 −
3-Cl-5-Br CHF₂          G²-8 −
3-Cl-5-Br CHFCl G²-5 −
3-Cl-5-Br CHCl₂         G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-Br CHFBr G²-8 −
3-Cl-5-Br CF_Three           G²-2 3-C (O) NH₂
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHCH_Three
3-Cl-5-Br CF_Three           G²-2 3-C (O) N (CH_Three)₂
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHEt
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHPr-n
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHPr-i
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHPr-c
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHCH₂CN
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHCH₂CH = CH₂
3-Cl-5-Br CF_Three           G²-2 3-C (O) NHCH₂C≡CH
3-Cl-5-Br CF_Three           G²-2 4-C (O) NH₂
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHCH_Three
3-Cl-5-Br CF_Three           G²-2 4-C (O) N (CH_Three)₂
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHEt
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHPr-n
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHPr-i
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHPr-c
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHCH₂CN
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHCH₂CH = CH₂
3-Cl-5-Br CF_Three           G²-2 4-C (O) NHCH₂C≡CH
3-Cl-5-Br CF_Three           G²-2 4-C (S) NH₂
3-Cl-5-Br CF_Three           G²-2 4-C (S) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-3 4-C (O) NH₂
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHCH_Three
3-Cl-5-Br CF_Three           G²-3 4-C (O) N (CH_Three)₂
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHEt
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHPr-n
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHPr-i
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHPr-c
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHCH₂CN
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHCH₂CH = CH₂
3-Cl-5-Br CF_Three           G²-3 4-C (O) NHCH₂C≡CH
3-Cl-5-Br CF_Three           G²-4 −
3-Cl-5-Br CF_Three           G²-4 4-C (O) NH₂
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHCH_Three
3-Cl-5-Br CF_Three           G²-4 4-C (O) N (CH_Three)₂
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHEt
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHPr-n
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHPr-i
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHPr-c
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHCH₂CN
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHCH₂CH = CH₂
3-Cl-5-Br CF_Three           G²-4 4-C (O) NHCH₂C≡CH
3-Cl-5-Br CF_Three           G²-5 −
3-Cl-5-Br CF_Three           G²-5 3-C (O) NH₂
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHCH_Three
3-Cl-5-Br CF_Three           G²-5 3-C (O) N (CH_Three)₂
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHEt
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHPr-n
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHPr-i
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHPr-c
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHCH₂CN
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHCH₂CH = CH₂
3-Cl-5-Br CF_Three           G²-5 3-C (O) NHCH₂C≡CH
3-Cl-5-Br CF_Three           G²-5 3-C (S) NH₂
3-Cl-5-Br CF_Three           G²-5 3-C (S) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-6 4-C (O) NH₂
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHCH_Three
3-Cl-5-Br CF_Three           G²-6 4-C (O) N (CH_Three)₂
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHEt
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHPr-n
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHPr-i
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHPr-c
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHCH₂CN
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHCH₂CH = CH₂
3-Cl-5-Br CF_Three           G²-6 4-C (O) NHCH₂C≡CH
3-Cl-5-Br CF_Three           G²-7 −
3-Cl-5-Br CF_Three           G²-8 −
3-Cl-5-Br CF_Three           G²-8 CH_Three
3-Cl-5-Br CF_Three           G²-9 −
3-Cl-5-Br CF_Three           G²-9 C (O) NH₂
3-Cl-5-Br CF_Three           G²-9 C (O) NHCH_Three
3-Cl-5-Br CF_Three           G²-9 C (O) N (CH_Three)₂
3-Cl-5-Br CF_Three           G²-9 C (O) NHEt
3-Cl-5-Br CF_Three           G²-9 C (O) NHPr-n
3-Cl-5-Br CF_Three           G²-9 C (O) NHPr-i
3-Cl-5-Br CF_Three           G²-9 C (O) NHPr-c
3-Cl-5-Br CF_Three           G²-9 C (O) NHCH₂CH₂F
3-Cl-5-Br CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-Br CF_Three           G²-9 C (O) NHCH₂CN
3-Cl-5-Br CF_Three           G²-9 C (O) NHCH₂CH = CH₂
3-Cl-5-Br CF_Three           G²-9 C (O) NHCH₂C≡CH
3-Cl-5-Br CF_Three           G²-9 C (S) NH₂
3-Cl-5-Br CF_Three           G²-9 C (S) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl G²-2 4-C (O) NH₂
3-Cl-5-Br CF₂Cl G²-2 4-C (O) NHCH_Three
3-Cl-5-Br CF₂Cl G²-2 4-C (O) NHEt
3-Cl-5-Br CF₂Cl G²-2 4-C (O) NHPr-i
3-Cl-5-Br CF₂Cl G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-5-Br CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl G²-3 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl G²-4 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl G²-5 −
3-Cl-5-Br CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl G²-6 4-C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Cl G²-8 −
3-Cl-5-Br CF₂Cl G²-9 −
3-Cl-5-Br CF₂Cl G²-9 C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂Br G²-5 −
3-Cl-5-Br CF₂Br G²-8 −
3-Cl-5-Br CF₂CHF₂       G²-5 −
3-Cl-5-Br CF₂CHF₂       G²-8 −
3-Cl-5-Br CF₂CF_Three        G²-9 −
3-Cl-5-Br CF₂OCH_Three       G²-9 C (O) NHCH₂CF_Three
3-Cl-5-Br CF₂SCH_Three       G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-Br T-3 G²-2 4-C (O) NHCH₂CF_Three
3,4-Br₂                    CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,4-Br₂                    CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,4-Br₂                    CF_Three           G²-5 −
3,4-Br₂                    CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,4-Br₂                    CF_Three           G²-8 −
3,4-Br₂                    CF_Three           G²-9 −
3,4-Br₂                    CF_Three           G²-9 C (O) NHCH₂CF_Three
3,4-Br₂                    CF₂Cl G²-5 −
3,4-Br₂                    CF₂Cl G²-8 −
3,5-Br₂                    CHF₂          G²-5 −
3,5-Br₂                    CHF₂          G²-8 −
3,5-Br₂                    CHFCl G²-5 −
3,5-Br₂                    CHCl₂         G²-5 3-C (O) NHCH₂CF_Three
3,5-Br₂                    CHFBr G²-8 −
3,5-Br₂                    CF_Three           G²-2 3-C (O) NH₂
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHCH_Three
3,5-Br₂                    CF_Three           G²-2 3-C (O) N (CH_Three)₂
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHEt
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHPr-n
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHPr-i
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHPr-c
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHCH₂CN
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHCH₂CH = CH₂
3,5-Br₂                    CF_Three           G²-2 3-C (O) NHCH₂C≡CH
3,5-Br₂                    CF_Three           G²-2 4-C (O) NH₂
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHCH_Three
3,5-Br₂                    CF_Three           G²-2 4-C (O) N (CH_Three)₂
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHEt
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHPr-n
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHPr-i
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHPr-c
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHCH₂CN
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHCH₂CH = CH₂
3,5-Br₂                    CF_Three           G²-2 4-C (O) NHCH₂C≡CH
3,5-Br₂                    CF_Three           G²-2 4-C (S) NH₂
3,5-Br₂                    CF_Three           G²-2 4-C (S) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-3 4-C (O) NH₂
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHCH_Three
3,5-Br₂                    CF_Three           G²-3 4-C (O) N (CH_Three)₂
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHEt
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHPr-n
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHPr-i
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHPr-c
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHCH₂CN
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHCH₂CH = CH₂
3,5-Br₂                    CF_Three           G²-3 4-C (O) NHCH₂C≡CH
3,5-Br₂                    CF_Three           G²-4 −
3,5-Br₂                    CF_Three           G²-4 4-C (O) NH₂
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHCH_Three
3,5-Br₂                    CF_Three           G²-4 4-C (O) N (CH_Three)₂
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHEt
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHPr-n
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHPr-i
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHPr-c
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHCH₂CN
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHCH₂CH = CH₂
3,5-Br₂                    CF_Three           G²-4 4-C (O) NHCH₂C≡CH
3,5-Br₂                    CF_Three           G²-5 −
3,5-Br₂                    CF_Three           G²-5 3-C (O) NH₂
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHCH_Three
3,5-Br₂                    CF_Three           G²-5 3-C (O) N (CH_Three)₂
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHEt
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHPr-n
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHPr-i
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHPr-c
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHCH₂CN
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHCH₂CH = CH₂
3,5-Br₂                    CF_Three           G²-5 3-C (O) NHCH₂C≡CH
3,5-Br₂                    CF_Three           G²-5 3-C (S) NH₂
3,5-Br₂                    CF_Three           G²-5 3-C (S) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-6 4-C (O) NH₂
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHCH_Three
3,5-Br₂                    CF_Three           G²-6 4-C (O) N (CH_Three)₂
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHEt
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHPr-n
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHPr-i
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHPr-c
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHCH₂CN
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHCH₂CH = CH₂
3,5-Br₂                    CF_Three           G²-6 4-C (O) NHCH₂C≡CH
3,5-Br₂                    CF_Three           G²-7 −
3,5-Br₂                    CF_Three           G²-8 −
3,5-Br₂                    CF_Three           G²-8 CH_Three
3,5-Br₂                    CF_Three           G²-9 −
3,5-Br₂                    CF_Three           G²-9 C (O) NH₂
3,5-Br₂                    CF_Three           G²-9 C (O) NHCH_Three
3,5-Br₂                    CF_Three           G²-9 C (O) N (CH_Three)₂
3,5-Br₂                    CF_Three           G²-9 C (O) NHEt
3,5-Br₂                    CF_Three           G²-9 C (O) NHPr-n
3,5-Br₂                    CF_Three           G²-9 C (O) NHPr-i
3,5-Br₂                    CF_Three           G²-9 C (O) NHPr-c
3,5-Br₂                    CF_Three           G²-9 C (O) NHCH₂CH₂F
3,5-Br₂                    CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Br₂                    CF_Three           G²-9 C (O) NHCH₂CN
3,5-Br₂                    CF_Three           G²-9 C (O) NHCH₂CH = CH₂
3,5-Br₂                    CF_Three           G²-9 C (O) NHCH₂C≡CH
3,5-Br₂                    CF_Three           G²-9 C (S) NH₂
3,5-Br₂                    CF_Three           G²-9 C (S) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl G²-2 4-C (O) NH₂
3,5-Br₂                    CF₂Cl G²-2 4-C (O) NHCH_Three
3,5-Br₂                    CF₂Cl G²-2 4-C (O) NHEt
3,5-Br₂                    CF₂Cl G²-2 4-C (O) NHPr-i
3,5-Br₂                    CF₂Cl G²-2 4-C (O) NHCH₂CH₂Cl
3,5-Br₂                    CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl G²-3 4-C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl G²-4 4-C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl G²-5 −
3,5-Br₂                    CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl G²-6 4-C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Cl G²-8 −
3,5-Br₂                    CF₂Cl G²-9 −
3,5-Br₂                    CF₂Cl G²-9 C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂Br G²-5 −
3,5-Br₂                    CF₂Br G²-8 −
3,5-Br₂                    CF₂CHF₂       G²-5 −
3,5-Br₂                    CF₂CHF₂       G²-8 −
3,5-Br₂                    CF₂CF_Three        G²-9 −
3,5-Br₂                    CF₂OCH_Three       G²-9 C (O) NHCH₂CF_Three
3,5-Br₂                    CF₂SCH_Three       G²-2 3-C (O) NHCH₂CF_Three
3,5-Br₂                    T-3 G²-2 4-C (O) NHCH₂CF_Three
3-F-5-I CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-F-5-I CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-F-5-I CF_Three           G²-5 −
3-F-5-I CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-5-I CF_Three           G²-8 −
3-F-5-I CF_Three           G²-9 −
3-F-5-I CF_Three           G²-9 C (O) NHCH₂CF_Three
3-F-5-I CF₂Cl G²-5 −
3-F-5-I CF₂Cl G²-8 −
3-Cl-5-I CHF₂          G²-5 −
3-Cl-5-I CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three           G²-2 4-C (O) NH₂
3-Cl-5-I CF_Three           G²-2 4-C (O) NHCH_Three
3-Cl-5-I CF_Three           G²-2 4-C (O) NHEt
3-Cl-5-I CF_Three           G²-2 4-C (O) NHPr-i
3-Cl-5-I CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-5-I CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three           G²-5 −
3-Cl-5-I CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Cl-5-I CF_Three           G²-8 −
3-Cl-5-I CF_Three           G²-9 −
3-Cl-5-I CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-I CF₂Cl G²-5 −
3-Cl-5-I CF₂Cl G²-8 −
3-Cl-5-I CF₂Cl G²-9 −
3-Cl-5-I CF₂Br G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-I CF₂CHF₂       G²-8 −
3,5-I₂                     CF_Three           G²-5 −
3,5-I₂                     CF_Three           G²-8 −
3-CH_Three-4-F CF_Three           G²-9 −
3-F-4-CH_Three                  CF_Three           G²-9 C (O) NHCH₂CF_Three
2-F-5-CH_Three                  CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-F-5-CH_Three                  CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CH_Three-4-Cl CF_Three           G²-5 −
3-Cl-4-CH_Three                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-CH_Three                 CF_Three           G²-5 −
3-Cl-5-CH_Three                 CF_Three           G²-8 −
3-Cl-5-CH_Three                 CF_Three           G²-9 −
3-Cl-5-CH_Three                 CF₂Cl G²-8 −
3-CH_Three-4-Br CF_Three           G²-9 −
3-Br-5-CH_Three                 CF_Three           G²-5 −
3-Br-5-CH_Three                 CF_Three           G²-8 −
3-Br-5-CH_Three                 CF_Three           G²-9 −
3,5- (CH_Three)₂                 CF_Three           G²-5 −
3,5- (CH_Three)₂                 CF_Three           G²-8 −
3-Br-5-Et CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CH_Three-5-Et CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-Pr-i CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-Pr-i CF_Three           G²-5 −
3-Cl-5-Bu-t CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-Bu-t CF_Three           G²-8 −
2-F-3-CF_Three                  CF_Three           G²-9 −
3-CF_Three-4-F CHF₂          G²-9 C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three           G²-2 4-C (O) NH₂
3-CF_Three-4-F CF_Three           G²-2 4-C (O) NHCH_Three
3-CF_Three-4-F CF_Three           G²-2 4-C (O) NHEt
3-CF_Three-4-F CF_Three           G²-2 4-C (O) NHPr-i
3-CF_Three-4-F CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-CF_Three-4-F CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three           G²-5 −
3-CF_Three-4-F CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-CF_Three-4-F CF_Three           G²-8 −
3-CF_Three-4-F CF_Three           G²-9 −
3-CF_Three-4-F CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-4-F CF₂Cl G²-5 −
3-CF_Three-4-F CF₂Cl G²-8 −
3-CF_Three-4-F CF₂Cl G²-9 −
3-CF_Three-4-F CF₂Br G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-4-F CF₂CHF₂       G²-2 4-C (O) NHCH₂CF_Three
3-F-4-CF_Three                  CF_Three           G²-5 −
2-F-5-CF_Three                  CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CHF₂          G²-8 −
3-F-5-CF_Three                  CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three           G²-2 4-C (O) NH₂
3-F-5-CF_Three                  CF_Three           G²-2 4-C (O) NHCH_Three
3-F-5-CF_Three                  CF_Three           G²-2 4-C (O) NHEt
3-F-5-CF_Three                  CF_Three           G²-2 4-C (O) NHPr-i
3-F-5-CF_Three                  CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-F-5-CF_Three                  CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three           G²-5 −
3-F-5-CF_Three                  CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF_Three           G²-8 −
3-F-5-CF_Three                  CF_Three           G²-9 −
3-F-5-CF_Three                  CF_Three           G²-9 C (O) NHCH₂CF_Three
3-F-5-CF_Three                  CF₂Cl G²-5 −
3-F-5-CF_Three                  CF₂Cl G²-8 −
3-F-5-CF_Three                  CF₂Cl G²-9 −
3-F-5-CF_Three                  CF₂Br G²-9 −
3-F-5-CF_Three                  CF₂CHF₂       G²-9 C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CHF₂          G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three           G²-2 4-C (O) NH₂
3-CF_Three-4-Cl CF_Three           G²-2 4-C (O) NHCH_Three
3-CF_Three-4-Cl CF_Three           G²-2 4-C (O) NHEt
3-CF_Three-4-Cl CF_Three           G²-2 4-C (O) NHPr-i
3-CF_Three-4-Cl CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-CF_Three-4-Cl CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three           G²-5 −
3-CF_Three-4-Cl CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF_Three           G²-8 −
3-CF_Three-4-Cl CF_Three           G²-9 −
3-CF_Three-4-Cl CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF₂Cl G²-5 −
3-CF_Three-4-Cl CF₂Cl G²-8 −
3-CF_Three-4-Cl CF₂Cl G²-9 −
3-CF_Three-4-Cl CF₂Br G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-4-Cl CF₂CHF₂       G²-5 −
3-Cl-5-CF_Three                 CHF₂          G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three           G²-2 3-C (O) NH₂
3-Cl-5-CF_Three                 CF_Three           G²-2 3-C (O) NHCH_Three
3-Cl-5-CF_Three                 CF_Three           G²-2 3-C (O) NHEt
3-Cl-5-CF_Three                 CF_Three           G²-2 3-C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3-Cl-5-CF_Three                 CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three           G²-2 4-C (O) NH₂
3-Cl-5-CF_Three                 CF_Three           G²-2 4-C (O) NHCH_Three
3-Cl-5-CF_Three                 CF_Three           G²-2 4-C (O) NHEt
3-Cl-5-CF_Three                 CF_Three           G²-2 4-C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-5-CF_Three                 CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three           G²-3 4-C (O) NH₂
3-Cl-5-CF_Three                 CF_Three           G²-3 4-C (O) NHCH_Three
3-Cl-5-CF_Three                 CF_Three           G²-3 4-C (O) NHEt
3-Cl-5-CF_Three                 CF_Three           G²-3 4-C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3-Cl-5-CF_Three                 CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three           G²-4 4-C (O) NH₂
3-Cl-5-CF_Three                 CF_Three           G²-4 4-C (O) NHCH_Three
3-Cl-5-CF_Three                 CF_Three           G²-4 4-C (O) NHEt
3-Cl-5-CF_Three                 CF_Three           G²-4 4-C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3-Cl-5-CF_Three                 CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three           G²-5 −
3-Cl-5-CF_Three                 CF_Three           G²-5 3-C (O) NH₂
3-Cl-5-CF_Three                 CF_Three           G²-5 3-C (O) NHCH_Three
3-Cl-5-CF_Three                 CF_Three           G²-5 3-C (O) NHEt
3-Cl-5-CF_Three                 CF_Three           G²-5 3-C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3-Cl-5-CF_Three                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three           G²-6 4-C (O) NH₂
3-Cl-5-CF_Three                 CF_Three           G²-6 4-C (O) NHCH_Three
3-Cl-5-CF_Three                 CF_Three           G²-6 4-C (O) NHEt
3-Cl-5-CF_Three                 CF_Three           G²-6 4-C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3-Cl-5-CF_Three                 CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF_Three           G²-8 −
3-Cl-5-CF_Three                 CF_Three           G²-9 −
3-Cl-5-CF_Three                 CF_Three           G²-9 C (O) NH₂
3-Cl-5-CF_Three                 CF_Three           G²-9 C (O) NHCH_Three
3-Cl-5-CF_Three                 CF_Three           G²-9 C (O) NHEt
3-Cl-5-CF_Three                 CF_Three           G²-9 C (O) NHPr-i
3-Cl-5-CF_Three                 CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3-Cl-5-CF_Three                 CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Cl G²-5 −
3-Cl-5-CF_Three                 CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Cl G²-8 −
3-Cl-5-CF_Three                 CF₂Cl G²-9 −
3-Cl-5-CF_Three                 CF₂Cl G²-9 C (O) NHCH₂CF_Three
3-Cl-5-CF_Three                 CF₂Br G²-8 −
3-Cl-5-CF_Three                 CF₂CHF₂       G²-9 −
3-Br-5-CF_Three                 CHF₂          G²-9 C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three           G²-2 3-C (O) NH₂
3-Br-5-CF_Three                 CF_Three           G²-2 3-C (O) NHCH_Three
3-Br-5-CF_Three                 CF_Three           G²-2 3-C (O) NHEt
3-Br-5-CF_Three                 CF_Three           G²-2 3-C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3-Br-5-CF_Three                 CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three           G²-2 4-C (O) NH₂
3-Br-5-CF_Three                 CF_Three           G²-2 4-C (O) NHCH_Three
3-Br-5-CF_Three                 CF_Three           G²-2 4-C (O) NHEt
3-Br-5-CF_Three                 CF_Three           G²-2 4-C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Br-5-CF_Three                 CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three           G²-3 4-C (O) NH₂
3-Br-5-CF_Three                 CF_Three           G²-3 4-C (O) NHCH_Three
3-Br-5-CF_Three                 CF_Three           G²-3 4-C (O) NHEt
3-Br-5-CF_Three                 CF_Three           G²-3 4-C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3-Br-5-CF_Three                 CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three           G²-4 4-C (O) NH₂
3-Br-5-CF_Three                 CF_Three           G²-4 4-C (O) NHCH_Three
3-Br-5-CF_Three                 CF_Three           G²-4 4-C (O) NHEt
3-Br-5-CF_Three                 CF_Three           G²-4 4-C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3-Br-5-CF_Three                 CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three           G²-5 −
3-Br-5-CF_Three                 CF_Three           G²-5 3-C (O) NH₂
3-Br-5-CF_Three                 CF_Three           G²-5 3-C (O) NHCH_Three
3-Br-5-CF_Three                 CF_Three           G²-5 3-C (O) NHEt
3-Br-5-CF_Three                 CF_Three           G²-5 3-C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3-Br-5-CF_Three                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three           G²-6 4-C (O) NH₂
3-Br-5-CF_Three                 CF_Three           G²-6 4-C (O) NHCH_Three
3-Br-5-CF_Three                 CF_Three           G²-6 4-C (O) NHEt
3-Br-5-CF_Three                 CF_Three           G²-6 4-C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3-Br-5-CF_Three                 CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF_Three           G²-8 −
3-Br-5-CF_Three                 CF_Three           G²-9 −
3-Br-5-CF_Three                 CF_Three           G²-9 C (O) NH₂
3-Br-5-CF_Three                 CF_Three           G²-9 C (O) NHCH_Three
3-Br-5-CF_Three                 CF_Three           G²-9 C (O) NHEt
3-Br-5-CF_Three                 CF_Three           G²-9 C (O) NHPr-i
3-Br-5-CF_Three                 CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3-Br-5-CF_Three                 CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Cl G²-5 −
3-Br-5-CF_Three                 CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Cl G²-8 −
3-Br-5-CF_Three                 CF₂Cl G²-9 −
3-Br-5-CF_Three                 CF₂Cl G²-9 C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂Br G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-CF_Three                 CF₂CHF₂       G²-2 4-C (O) NHCH₂CF_Three
3-CH_Three-5-CF_Three                CF_Three           G²-5 −
3-CH_Three-5-CF_Three                CF_Three           G²-8 −
3-CH_Three-5-CF_Three                CF_Three           G²-9 −
3-CH_Three-5-CF_Three                CF₂Cl G²-5 −
3-Et-5-CF_Three                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Pr-i-5-CF_Three               CF_Three           G²-8 −
3-Bu-t-5-CF_Three               CF_Three           G²-9 −
3,5- (CF_Three)₂                 CHF₂          G²-5 −
3,5- (CF_Three)₂                 CHF₂          G²-8 −
3,5- (CF_Three)₂                 CHFCl G²-9 C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CHCl₂         G²-2 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CHFBr G²-2 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) N (CH_Three)₂
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHEt
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHPr-n
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHPr-c
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHCH₂CN
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHCH₂CH = CH₂
3,5- (CF_Three)₂                 CF_Three           G²-2 3-C (O) NHCH₂C≡CH
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) N (CH_Three)₂
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHEt
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHPr-n
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHPr-c
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHCH₂CN
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHCH₂CH = CH₂
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (O) NHCH₂C≡CH
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (S) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-2 4-C (S) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) N (CH_Three)₂
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHEt
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHPr-n
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHPr-c
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHCH₂CN
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHCH₂CH = CH₂
3,5- (CF_Three)₂                 CF_Three           G²-3 4-C (O) NHCH₂C≡CH
3,5- (CF_Three)₂                 CF_Three           G²-4 −
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) N (CH_Three)₂
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHEt
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHPr-n
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHPr-c
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHCH₂CN
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHCH₂CH = CH₂
3,5- (CF_Three)₂                 CF_Three           G²-4 4-C (O) NHCH₂C≡CH
3,5- (CF_Three)₂                 CF_Three           G²-5 −
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) N (CH_Three)₂
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHEt
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHPr-n
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHPr-c
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHCH₂CN
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHCH₂CH = CH₂
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (O) NHCH₂C≡CH
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (S) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-5 3-C (S) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) N (CH_Three)₂
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHEt
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHPr-n
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHPr-c
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHCH₂CN
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHCH₂CH = CH₂
3,5- (CF_Three)₂                 CF_Three           G²-6 4-C (O) NHCH₂C≡CH
3,5- (CF_Three)₂                 CF_Three           G²-7 −
3,5- (CF_Three)₂                 CF_Three           G²-8 −
3,5- (CF_Three)₂                 CF_Three           G²-8 CH_Three
3,5- (CF_Three)₂                 CF_Three           G²-9 −
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHCH_Three
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) N (CH_Three)₂
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHEt
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHPr-n
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHPr-i
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHPr-c
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHCH₂CH₂F
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHCH₂CN
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHCH₂CH = CH₂
3,5- (CF_Three)₂                 CF_Three           G²-9 C (O) NHCH₂C≡CH
3,5- (CF_Three)₂                 CF_Three           G²-9 C (S) NH₂
3,5- (CF_Three)₂                 CF_Three           G²-9 C (S) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl G²-2 4-C (O) NH₂
3,5- (CF_Three)₂                 CF₂Cl G²-2 4-C (O) NHCH_Three
3,5- (CF_Three)₂                 CF₂Cl G²-2 4-C (O) NHEt
3,5- (CF_Three)₂                 CF₂Cl G²-2 4-C (O) NHPr-i
3,5- (CF_Three)₂                 CF₂Cl G²-2 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂                 CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl G²-3 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl G²-4 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl G²-5 −
3,5- (CF_Three)₂                 CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl G²-6 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Cl G²-8 −
3,5- (CF_Three)₂                 CF₂Cl G²-9 −
3,5- (CF_Three)₂                 CF₂Cl G²-9 C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂Br G²-5 −
3,5- (CF_Three)₂                 CF₂Br G²-8 −
3,5- (CF_Three)₂                 CF₂CHF₂       G²-5 −
3,5- (CF_Three)₂                 CF₂CHF₂       G²-8 −
3,5- (CF_Three)₂                 CF₂CF_Three        G²-5 −
3,5- (CF_Three)₂                 CF₂OCH_Three       G²-5 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂                 CF₂SCH_Three       G²-8 −
3,5- (CF_Three)₂                 T-3 G²-9 −
3-Cl-5-CF₂CF_Three              CF_Three           G²-5 −
3-Cl-5-CF₂CF_Three              CF_Three           G²-8 −
3-Br-5-CF₂CF_Three              CF_Three           G²-5 −
3-Br-5-CF₂CF_Three              CF_Three           G²-8 −
3-CH_Three-5-CF₂CF_Three             CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-CF₂CF₂CF_Three           CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-CF₂CF₂CF_Three           CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CH_Three-5-CF₂CF₂CF_Three          CF_Three           G²-5 −
3-Cl-5-CF (CF_Three)₂            CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-CF (CF_Three)₂            CF_Three           G²-8 −
3-CH_Three-5-CF (CF_Three)₂           CF_Three           G²-9 −
3-Cl-5-CH₂OCH_Three             CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-CH₂OCH₂CF_Three          CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-C (CF_Three)₂OH CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-C (CF_Three)₂OH CF_Three           G²-5 −
3-CH_Three-5-C (CF_Three)₂OH CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5- [C (CF_Three)₂OH]₂           CF_Three           G²-8 −
3-Cl-5-C (CF_Three)₂OCH_Three         CF_Three           G²-9 −
3-Br-5-C (CF_Three)₂OCH_Three         CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CH_Three-5-C (CF_Three)₂OCH_Three        CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5- [C (CF_Three)₂OCH_Three]₂         CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-5-CH₂SCH_Three            CF_Three           G²-5 −
3-CF_Three-5-CH₂S (O) CH_Three         CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three-5-CH₂SO₂CH_Three          CF_Three           G²-8 −
3-Cl-4-OCH_Three                CF_Three           G²-9 −
3-Cl-5-OCH_Three                CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Br-5-OCH_Three                CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-5-OCH_Three               CF_Three           G²-5 −
3-CF_Three-5-OCH_Three               CF_Three           G²-8 −
3-CF_Three-5-OCH_Three               CF_Three           G²-9 −
3-CF_Three-5-OCH_Three               CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3-F-4-OCHF₂                CF_Three           G²-5 −
3-Cl-4-OCHF₂               CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CHF₂          G²-8 −
3-Cl-5-OCHF₂               CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF_Three           G²-2 4-C (O) NH₂
3-Cl-5-OCHF₂               CF_Three           G²-2 4-C (O) NHCH_Three
3-Cl-5-OCHF₂               CF_Three           G²-2 4-C (O) NHEt
3-Cl-5-OCHF₂               CF_Three           G²-2 4-C (O) NHPr-i
3-Cl-5-OCHF₂               CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-5-OCHF₂               CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF_Three           G²-5 −
3-Cl-5-OCHF₂               CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF_Three           G²-8 −
3-Cl-5-OCHF₂               CF_Three           G²-9 −
3-Cl-5-OCHF₂               CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-OCHF₂               CF₂Cl G²-5 −
3-Cl-5-OCHF₂               CF₂Cl G²-8 −
3-Cl-5-OCHF₂               CF₂Cl G²-9 −
3-Cl-5-OCHF₂               CF₂Br G²-9 −
3-Cl-5-OCHF₂               CF₂CHF₂       G²-9 C (O) NHCH₂CF_Three 
3-Br-4-OCHF₂               CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF_Three           G²-5 −
3-Br-5-OCHF₂               CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF_Three           G²-8 −
3-Br-5-OCHF₂               CF_Three           G²-9 −
3-Br-5-OCHF₂               CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Br-5-OCHF₂               CF₂Cl G²-5 −
3-Br-5-OCHF₂               CF₂Cl G²-8 −
3-CH_Three-5-OCHF₂              CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-5-OCHF₂              CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-5-OCHF₂              CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-5-OCHF₂              CF_Three           G²-5 −
3-CF_Three-5-OCHF₂              CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three-5-OCHF₂              CF_Three           G²-8 −
3-CF_Three-5-OCHF₂              CF_Three           G²-9 −
3-CF_Three-5-OCHF₂              CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-5-OCHF₂              CF₂Cl G²-5 −
3-CF_Three-5-OCHF₂              CF₂Cl G²-8 −
3,5- (OCHF₂)₂               CF_Three           G²-5 −
3-F-4-OCF_Three                 CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-4-OCF_Three                CF_Three           G²-8 −
3-Cl-5-OCF_Three                CHF₂          G²-9 −
3-Cl-5-OCF_Three                CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF_Three           G²-2 4-C (O) NH₂
3-Cl-5-OCF_Three                CF_Three           G²-2 4-C (O) NHCH_Three
3-Cl-5-OCF_Three                CF_Three           G²-2 4-C (O) NHEt
3-Cl-5-OCF_Three                CF_Three           G²-2 4-C (O) NHPr-i
3-Cl-5-OCF_Three                CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-5-OCF_Three                CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF_Three           G²-5 −
3-Cl-5-OCF_Three                CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF_Three           G²-8 −
3-Cl-5-OCF_Three                CF_Three           G²-9 −
3-Cl-5-OCF_Three                CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF₂Cl G²-5 −
3-Cl-5-OCF_Three                CF₂Cl G²-8 −
3-Cl-5-OCF_Three                CF₂Cl G²-9 −
3-Cl-5-OCF_Three                CF₂Br G²-9 C (O) NHCH₂CF_Three
3-Cl-5-OCF_Three                CF₂CHF₂       G²-2 3-C (O) NHCH₂CF_Three
3-Br-4-OCF_Three                CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF_Three           G²-5 −
3-Br-5-OCF_Three                CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF_Three           G²-8 −
3-Br-5-OCF_Three                CF_Three           G²-9 −
3-Br-5-OCF_Three                CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Br-5-OCF_Three                CF₂Cl G²-5 −
3-Br-5-OCF_Three                CF₂Cl G²-8 −
3-CH_Three-5-OCF_Three               CF_Three           G²-5 −
3-CF_Three-5-OCF_Three               CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-5-OCF_Three               CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-5-OCF_Three               CF_Three           G²-5 −
3-CF_Three-5-OCF_Three               CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three-5-OCF_Three               CF_Three           G²-8 −
3-CF_Three-5-OCF_Three               CF_Three           G²-9 −
3-CF_Three-5-OCF_Three               CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-5-OCF_Three               CF₂Cl G²-5 −
3-CF_Three-5-OCF_Three               CF₂Cl G²-8 −
3-F-5-OCF₂Br CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-OCF₂Br CF_Three           G²-8 −
3-CH_Three-5-OCF₂Br CF_Three           G²-9 −
3-F-5-OCF₂CHF₂             CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-OCF₂CHF₂            CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CH_Three-5-OCF₂CHF₂           CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-F-5-OCF₂CHFCl CF_Three           G²-5 −
3-Cl-5-OCF₂CHFCl CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-OCF₂CHFCl CF_Three           G²-8 −
3-F-5-OCF₂CHFCF_Three           CF_Three           G²-9 −
3-Cl-5-OCF₂CHFCF_Three          CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CH_Three-5-OCF₂CHFCF_Three         CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-F-5-OCF₂CHFOCF_Three          CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-OCF₂CHFOCF_Three         CF_Three           G²-5 −
3-CH_Three-5-OCF₂CHFOCF_Three        CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF₂OCF₂O-4 CF_Three           G²-8 −
3-OCF₂O-4 CF_Three           G²-9 −
3-OCF₂CF₂O-4 CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-SCH_Three                CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-S (O) CH_Three             CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-SO₂CH_Three              CF_Three           G²-5 −
3-Br-5-SCH_Three                CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-S (O) CH_Three             CF_Three           G²-8 −
3-Br-5-SO₂CH_Three              CF_Three           G²-9 −
3-Cl-5-SCF_Three                CHF₂          G²-9 C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three           G²-2 4-C (O) NH₂
3-Cl-5-SCF_Three                CF_Three           G²-2 4-C (O) NHCH_Three
3-Cl-5-SCF_Three                CF_Three           G²-2 4-C (O) NHEt
3-Cl-5-SCF_Three                CF_Three           G²-2 4-C (O) NHPr-i
3-Cl-5-SCF_Three                CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-5-SCF_Three                CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three           G²-5 −
3-Cl-5-SCF_Three                CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF_Three           G²-8 −
3-Cl-5-SCF_Three                CF_Three           G²-9 −
3-Cl-5-SCF_Three                CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF₂Cl G²-5 −
3-Cl-5-SCF_Three                CF₂Cl G²-8 −
3-Cl-5-SCF_Three                CF₂Cl G²-9 −
3-Cl-5-SCF_Three                CF₂Br G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-SCF_Three                CF₂CHF₂       G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-S (O) CF_Three             CF_Three           G²-5 −
3-Cl-5-S (O) CF_Three             CF_Three           G²-8 −
3-Cl-5-SO₂CF_Three              CF_Three           G²-5 −
3-Cl-5-SO₂CF_Three              CF_Three           G²-8 −
3-Br-5-SCF_Three                CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-SCF_Three                CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-SCF_Three                CF_Three           G²-5 −
3-Br-5-SCF_Three                CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-SCF_Three                CF_Three           G²-8 −
3-Br-5-SCF_Three                CF_Three           G²-9 −
3-Br-5-SCF_Three                CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Br-5-SCF_Three                CF₂Cl G²-5 −
3-Br-5-SCF_Three                CF₂Cl G²-8 −
3-Br-5-S (O) CF_Three             CF_Three           G²-5 −
3-Br-5-S (O) CF_Three             CF_Three           G²-8 −
3-Br-5-SO₂CF_Three              CF_Three           G²-5 −
3-Br-5-SO₂CF_Three              CF_Three           G²-8 −
3-Cl-5-SCF₂CHFCl CF_Three           G²-5 −
3-Cl-5-SCF₂CHFCl CF_Three           G²-8 −
3-Cl-5-S (O) CF₂CHFCl CF_Three           G²-5 −
3-Cl-5-SO₂CF₂CHFCl CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Br-5-SCF₂CHFCl CF_Three           G²-5 −
3-Br-5-SCF₂CHFCl CF_Three           G²-8 −
3-Br-5-S (O) CF₂CHFCl CF_Three           G²-8 −
3-Br-5-SO₂CF₂CHFCl CF_Three           G²-9 −
3-Cl-5-SPh CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-S (O) Ph CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-SO₂Ph CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-NO₂-4-F CF_Three           G²-5 −
2-F-5-NO₂                  CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-5-NO₂                  CF_Three           G²-8 −
3-NO₂-4-Cl CF_Three           G²-9 −
3-Cl-5-NO₂                 CF_Three           G²-5 −
3-Cl-5-NO₂                 CF_Three           G²-8 −
3-Br-5-NO₂                 CF_Three           G²-5 −
3-Br-5-NO₂                 CF_Three           G²-8 −
3-CH_Three-5-NO₂                CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-4-NO₂                CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-5-NO₂                CF_Three           G²-5 −
3-CF_Three-5-NO₂                CF_Three           G²-8 −
3-CF_Three-5-NO₂                CF_Three           G²-9 −
3-CF_Three-5-NO₂                CH₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,5- (NO₂)₂                 CF_Three           G²-5 −
3-Cl-5-NHC (O) CF_Three           CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-N (CH_Three) C (O) CF_Three       CF_Three           G²-8 −
3-Cl-5-N (Et) C (O) CF_Three        CF_Three           G²-9 −
3-Cl-5-N (CH_Three) C (O) CF₂Cl CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-N (Et) C (O) CF₂Cl CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-N (CH_Three) C (O) CF₂Br CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-N (Et) C (O) CF₂Br CF_Three           G²-5 −
3-Cl-5-N (CH_Three) SO₂CF_Three        CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-N (Et) SO₂CF_Three         CF_Three           G²-8 −
3-CF_Three-5-NHC (O) CH_Three          CF_Three           G²-9 −
3-CF_Three-5-NHC (O) CF_Three          CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) C (O) CH_Three      CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-5-N (Et) C (O) CH_Three       CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) C (O) CF_Three      CF_Three           G²-5 −
3-CF_Three-5-N (Et) C (O) CF_Three       CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) C (O) CF₂Cl CF_Three           G²-8 −
3-CF_Three-5-N (Et) C (O) CF₂Cl CF_Three           G²-9 −
3-CF_Three-5-N (CH_Three) C (O) CF₂Br CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-5-N (Et) C (O) CF₂Br CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-5-N (CH_Three) SO₂CF_Three       CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-5-N (Et) SO₂CF_Three        CF_Three           G²-5 −
3-CN-4-F CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-4-CN CF_Three           G²-8 −
3-Cl-4-CN CF_Three           G²-9 −
3-F-5-CN CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-5-CN CF_Three           G²-5 −
3-Cl-5-CN CF_Three           G²-8 −
3-Cl-5-CN CF_Three           G²-9 −
3-Br-5-CN CF_Three           G²-5 −
3-Br-5-CN CF_Three           G²-8 −
3-Br-5-CN CF_Three           G²-9 −
3-CH_Three-5-CN CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-5-CN CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-CF_Three-5-CN CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-CF_Three-5-CN CF_Three           G²-5 −
3-CF_Three-5-CN CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three-5-CN CF_Three           G²-8 −
3-CF_Three-5-CN CF_Three           G²-9 −
3-CF_Three-5-CN CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-5-CN CF₂Cl G²-5 −
3-CF_Three-5-CN CF₂Cl G²-8 −
3-NO₂-5-CN CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5- (CN)₂                  CF_Three           G²-5 −
3-Cl-5-C (O) OCH_Three            CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-C (O) NH₂             CF_Three           G²-8 −
3-Cl-5-C (O) NHCH_Three           CF_Three           G²-9 −
3-Cl-5-C (O) N (CH_Three)₂         CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Br-5-C (O) OCH_Three            CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Br-5-C (O) NH₂             CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Br-5-C (O) NHCH_Three           CF_Three           G²-5 −
3-Br-5-C (O) N (CH_Three)₂         CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-CF_Three-5-C (O) OCH_Three           CF_Three           G²-8 −
3-CF_Three-5-C (O) NH₂            CF_Three           G²-9 −
3-CF_Three-5-C (O) NHCH_Three          CF_Three           G²-9 C (O) NHCH₂CF_Three
3-CF_Three-5-C (O) N (CH_Three)₂        CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-5-SO₂OCH_Three             CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-5-SO₂NH₂              CF_Three           G²-5 −
3-Cl-5-SO₂NHCH_Three            CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-5-SO₂N (CH_Three)₂          CF_Three           G²-8 −
2-CH = CHCH = CH-3 CF_Three           G²-9 −
3-CH = CHCH = CH-4 CF_Three           G²-9 C (O) NHCH₂CF_Three
2,3,4-F_Three                   CF_Three           G²-2 3-C (O) NHCH₂CF_Three
2,3,5-F_Three                   CF_Three           G²-2 4-C (O) NHCH₂CF_Three
2,3,6-F_Three                   CF_Three           G²-5 −
2,4,5-F_Three                   CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF_Three           G²-5 −
3,4,5-F_Three                   CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF_Three           G²-8 −
3,4,5-F_Three                   CF_Three           G²-9 −
3,4,5-F_Three                   CF_Three           G²-9 C (O) NHCH₂CF_Three
3,4,5-F_Three                   CF₂Cl G²-5 −
3,4,5-F_Three                   CF₂Cl G²-8 −
2,6-F₂-3-Cl CF_Three           G²-8 −
3,5-Cl₂-4-F CHF₂          G²-9 −
3,5-Cl₂-4-F CF_Three           G²-2 3-C (O) NH₂
3,5-Cl₂-4-F CF_Three           G²-2 3-C (O) NHCH_Three
3,5-Cl₂-4-F CF_Three           G²-2 3-C (O) NHEt
3,5-Cl₂-4-F CF_Three           G²-2 3-C (O) NHPr-i
3,5-Cl₂-4-F CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3,5-Cl₂-4-F CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three           G²-2 4-C (O) NH₂
3,5-Cl₂-4-F CF_Three           G²-2 4-C (O) NHCH_Three
3,5-Cl₂-4-F CF_Three           G²-2 4-C (O) NHEt
3,5-Cl₂-4-F CF_Three           G²-2 4-C (O) NHPr-i
3,5-Cl₂-4-F CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂-4-F CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three           G²-3 4-C (O) NH₂
3,5-Cl₂-4-F CF_Three           G²-3 4-C (O) NHCH_Three
3,5-Cl₂-4-F CF_Three           G²-3 4-C (O) NHEt
3,5-Cl₂-4-F CF_Three           G²-3 4-C (O) NHPr-i
3,5-Cl₂-4-F CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂-4-F CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three           G²-4 4-C (O) NH₂
3,5-Cl₂-4-F CF_Three           G²-4 4-C (O) NHCH_Three
3,5-Cl₂-4-F CF_Three           G²-4 4-C (O) NHEt
3,5-Cl₂-4-F CF_Three           G²-4 4-C (O) NHPr-i
3,5-Cl₂-4-F CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂-4-F CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three           G²-5 −
3,5-Cl₂-4-F CF_Three           G²-5 3-C (O) NH₂
3,5-Cl₂-4-F CF_Three           G²-5 3-C (O) NHCH_Three
3,5-Cl₂-4-F CF_Three           G²-5 3-C (O) NHEt
3,5-Cl₂-4-F CF_Three           G²-5 3-C (O) NHPr-i
3,5-Cl₂-4-F CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3,5-Cl₂-4-F CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three           G²-6 4-C (O) NH₂
3,5-Cl₂-4-F CF_Three           G²-6 4-C (O) NHCH_Three
3,5-Cl₂-4-F CF_Three           G²-6 4-C (O) NHEt
3,5-Cl₂-4-F CF_Three           G²-6 4-C (O) NHPr-i
3,5-Cl₂-4-F CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3,5-Cl₂-4-F CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF_Three           G²-8 −
3,5-Cl₂-4-F CF_Three           G²-9 −
3,5-Cl₂-4-F CF_Three           G²-9 C (O) NH₂
3,5-Cl₂-4-F CF_Three           G²-9 C (O) NHCH_Three
3,5-Cl₂-4-F CF_Three           G²-9 C (O) NHEt
3,5-Cl₂-4-F CF_Three           G²-9 C (O) NHPr-i
3,5-Cl₂-4-F CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3,5-Cl₂-4-F CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Cl G²-5 −
3,5-Cl₂-4-F CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Cl G²-8 −
3,5-Cl₂-4-F CF₂Cl G²-9 −
3,5-Cl₂-4-F CF₂Cl G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂Br G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂-4-F CF₂CHF₂       G²-2 3-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CHF₂          G²-5 −
3,4,5-Cl_Three                  CHF₂          G²-8 −
3,4,5-Cl_Three                  CHFCl G²-2 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CHCl₂         G²-5 −
3,4,5-Cl_Three                  CHFBr G²-5 3-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NH₂
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) N (CH_Three)₂
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHEt
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHPr-n
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHPr-c
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHCH₂CN
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHCH₂CH = CH₂
3,4,5-Cl_Three                  CF_Three           G²-2 3-C (O) NHCH₂C≡CH
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NH₂
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) N (CH_Three)₂
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHEt
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHPr-n
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHPr-c
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHCH₂CN
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHCH₂CH = CH₂
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (O) NHCH₂C≡CH
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (S) NH₂
3,4,5-Cl_Three                  CF_Three           G²-2 4-C (S) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NH₂
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) N (CH_Three)₂
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHEt
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHPr-n
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHPr-c
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHCH₂CN
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHCH₂CH = CH₂
3,4,5-Cl_Three                  CF_Three           G²-3 4-C (O) NHCH₂C≡CH
3,4,5-Cl_Three                  CF_Three           G²-4 −
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NH₂
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) N (CH_Three)₂
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHEt
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHPr-n
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHPr-c
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHCH₂CN
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHCH₂CH = CH₂
3,4,5-Cl_Three                  CF_Three           G²-4 4-C (O) NHCH₂C≡CH
3,4,5-Cl_Three                  CF_Three           G²-5 −
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NH₂
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) N (CH_Three)₂
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHEt
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHPr-n
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHPr-c
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHCH₂CN
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHCH₂CH = CH₂
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (O) NHCH₂C≡CH
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (S) NH₂
3,4,5-Cl_Three                  CF_Three           G²-5 3-C (S) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NH₂
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) N (CH_Three)₂
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHEt
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHPr-n
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHPr-c
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHCH₂CN
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHCH₂CH = CH₂
3,4,5-Cl_Three                  CF_Three           G²-6 4-C (O) NHCH₂C≡CH
3,4,5-Cl_Three                  CF_Three           G²-7 −
3,4,5-Cl_Three                  CF_Three           G²-8 −
3,4,5-Cl_Three                  CF_Three           G²-8 CH_Three
3,4,5-Cl_Three                  CF_Three           G²-9 −
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NH₂
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHCH_Three
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) N (CH_Three)₂
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHEt
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHPr-n
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHPr-i
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHPr-c
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHCH₂CH₂F
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHCH₂CN
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHCH₂CH = CH₂
3,4,5-Cl_Three                  CF_Three           G²-9 C (O) NHCH₂C≡CH
3,4,5-Cl_Three                  CF_Three           G²-9 C (S) NH₂
3,4,5-Cl_Three                  CF_Three           G²-9 C (S) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl G²-2 4-C (O) NH₂
3,4,5-Cl_Three                  CF₂Cl G²-2 4-C (O) NHCH_Three
3,4,5-Cl_Three                  CF₂Cl G²-2 4-C (O) NHEt
3,4,5-Cl_Three                  CF₂Cl G²-2 4-C (O) NHPr-i
3,4,5-Cl_Three                  CF₂Cl G²-2 4-C (O) NHCH₂CH₂Cl
3,4,5-Cl_Three                  CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl G²-3 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl G²-4 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl G²-5 −
3,4,5-Cl_Three                  CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl G²-6 4-C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Cl G²-8 −
3,4,5-Cl_Three                  CF₂Cl G²-9 −
3,4,5-Cl_Three                  CF₂Cl G²-9 C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  CF₂Br G²-5 −
3,4,5-Cl_Three                  CF₂Br G²-8 −
3,4,5-Cl_Three                  CF₂CHF₂       G²-5 −
3,4,5-Cl_Three                  CF₂CHF₂       G²-8 −
3,4,5-Cl_Three                  CF₂CF_Three        G²-8 −
3,4,5-Cl_Three                  CF₂OCH_Three       G²-9 −
3,4,5-Cl_Three                  CF₂SCH_Three       G²-9 C (O) NHCH₂CF_Three
3,4,5-Cl_Three                  T-3 G²-2 3-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CHF₂          G²-2 4-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three           G²-2 3-C (O) NH₂
3,5-Br₂-4-F CF_Three           G²-2 3-C (O) NHCH_Three
3,5-Br₂-4-F CF_Three           G²-2 3-C (O) NHEt
3,5-Br₂-4-F CF_Three           G²-2 3-C (O) NHPr-i
3,5-Br₂-4-F CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3,5-Br₂-4-F CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three           G²-2 4-C (O) NH₂
3,5-Br₂-4-F CF_Three           G²-2 4-C (O) NHCH_Three
3,5-Br₂-4-F CF_Three           G²-2 4-C (O) NHEt
3,5-Br₂-4-F CF_Three           G²-2 4-C (O) NHPr-i
3,5-Br₂-4-F CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,5-Br₂-4-F CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three           G²-3 4-C (O) NH₂
3,5-Br₂-4-F CF_Three           G²-3 4-C (O) NHCH_Three
3,5-Br₂-4-F CF_Three           G²-3 4-C (O) NHEt
3,5-Br₂-4-F CF_Three           G²-3 4-C (O) NHPr-i
3,5-Br₂-4-F CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3,5-Br₂-4-F CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three           G²-4 4-C (O) NH₂
3,5-Br₂-4-F CF_Three           G²-4 4-C (O) NHCH_Three
3,5-Br₂-4-F CF_Three           G²-4 4-C (O) NHEt
3,5-Br₂-4-F CF_Three           G²-4 4-C (O) NHPr-i
3,5-Br₂-4-F CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3,5-Br₂-4-F CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three           G²-5 −
3,5-Br₂-4-F CF_Three           G²-5 3-C (O) NH₂
3,5-Br₂-4-F CF_Three           G²-5 3-C (O) NHCH_Three
3,5-Br₂-4-F CF_Three           G²-5 3-C (O) NHEt
3,5-Br₂-4-F CF_Three           G²-5 3-C (O) NHPr-i
3,5-Br₂-4-F CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3,5-Br₂-4-F CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three           G²-6 4-C (O) NH₂
3,5-Br₂-4-F CF_Three           G²-6 4-C (O) NHCH_Three
3,5-Br₂-4-F CF_Three           G²-6 4-C (O) NHEt
3,5-Br₂-4-F CF_Three           G²-6 4-C (O) NHPr-i
3,5-Br₂-4-F CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3,5-Br₂-4-F CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF_Three           G²-8 −
3,5-Br₂-4-F CF_Three           G²-9 −
3,5-Br₂-4-F CF_Three           G²-9 C (O) NH₂
3,5-Br₂-4-F CF_Three           G²-9 C (O) NHCH_Three
3,5-Br₂-4-F CF_Three           G²-9 C (O) NHEt
3,5-Br₂-4-F CF_Three           G²-9 C (O) NHPr-i
3,5-Br₂-4-F CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3,5-Br₂-4-F CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Cl G²-5 −
3,5-Br₂-4-F CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Cl G²-8 −
3,5-Br₂-4-F CF₂Cl G²-9 −
3,5-Br₂-4-F CF₂Cl G²-9 C (O) NHCH₂CF_Three
3,5-Br₂-4-F CF₂Br G²-5 −
3,5-Br₂-4-F CF₂CHF₂       G²-5 3-C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF_Three           G²-5 −
3,4,5-Br_Three                  CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF_Three           G²-8 −
3,4,5-Br_Three                  CF_Three           G²-9 −
3,4,5-Br_Three                  CF_Three           G²-9 C (O) NHCH₂CF_Three
3,4,5-Br_Three                  CF₂Cl G²-5 −
3,4,5-Br_Three                  CF₂Cl G²-8 −
2,3-F₂-4-CH_Three               CF_Three           G²-8 −
3,5-F₂-4-CH_Three               CF_Three           G²-9 −
3,5-Cl₂-4-CH_Three              CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Br₂-4-CH_Three              CF_Three           G²-2 3-C (O) NHCH₂CF_Three
2,3-F₂-4-CF_Three               CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CHF₂          G²-5 −
3,4-F₂-5-CF_Three               CF_Three           G²-2 3-C (O) NH₂
3,4-F₂-5-CF_Three               CF_Three           G²-2 3-C (O) NHCH_Three
3,4-F₂-5-CF_Three               CF_Three           G²-2 3-C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three           G²-2 3-C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3,4-F₂-5-CF_Three               CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three           G²-2 4-C (O) NH₂
3,4-F₂-5-CF_Three               CF_Three           G²-2 4-C (O) NHCH_Three
3,4-F₂-5-CF_Three               CF_Three           G²-2 4-C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three           G²-2 4-C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,4-F₂-5-CF_Three               CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three           G²-3 4-C (O) NH₂
3,4-F₂-5-CF_Three               CF_Three           G²-3 4-C (O) NHCH_Three
3,4-F₂-5-CF_Three               CF_Three           G²-3 4-C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three           G²-3 4-C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3,4-F₂-5-CF_Three               CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three           G²-4 4-C (O) NH₂
3,4-F₂-5-CF_Three               CF_Three           G²-4 4-C (O) NHCH_Three
3,4-F₂-5-CF_Three               CF_Three           G²-4 4-C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three           G²-4 4-C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3,4-F₂-5-CF_Three               CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three           G²-5 −
3,4-F₂-5-CF_Three               CF_Three           G²-5 3-C (O) NH₂
3,4-F₂-5-CF_Three               CF_Three           G²-5 3-C (O) NHCH_Three
3,4-F₂-5-CF_Three               CF_Three           G²-5 3-C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three           G²-5 3-C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3,4-F₂-5-CF_Three               CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three           G²-6 4-C (O) NH₂
3,4-F₂-5-CF_Three               CF_Three           G²-6 4-C (O) NHCH_Three
3,4-F₂-5-CF_Three               CF_Three           G²-6 4-C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three           G²-6 4-C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3,4-F₂-5-CF_Three               CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF_Three           G²-8 −
3,4-F₂-5-CF_Three               CF_Three           G²-9 −
3,4-F₂-5-CF_Three               CF_Three           G²-9 C (O) NH₂
3,4-F₂-5-CF_Three               CF_Three           G²-9 C (O) NHCH_Three
3,4-F₂-5-CF_Three               CF_Three           G²-9 C (O) NHEt
3,4-F₂-5-CF_Three               CF_Three           G²-9 C (O) NHPr-i
3,4-F₂-5-CF_Three               CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3,4-F₂-5-CF_Three               CF_Three           G²-9 C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Cl G²-5 −
3,4-F₂-5-CF_Three               CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Cl G²-8 −
3,4-F₂-5-CF_Three               CF₂Cl G²-9 −
3,4-F₂-5-CF_Three               CF₂Cl G²-9 C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂Br G²-5 3-C (O) NHCH₂CF_Three
3,4-F₂-5-CF_Three               CF₂CHF₂       G²-8 −
2-F-3-Cl-5-CF_Three             CF_Three           G²-9 −
3-Cl-4-F-5-CF_Three             CHF₂          G²-9 C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 3-C (O) NH₂
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 3-C (O) NHCH_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 3-C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 3-C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 4-C (O) NH₂
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 4-C (O) NHCH_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 4-C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 4-C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3-Cl-4-F-5-CF_Three             CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-3 4-C (O) NH₂
3-Cl-4-F-5-CF_Three             CF_Three           G²-3 4-C (O) NHCH_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-3 4-C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three           G²-3 4-C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3-Cl-4-F-5-CF_Three             CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-4 4-C (O) NH₂
3-Cl-4-F-5-CF_Three             CF_Three           G²-4 4-C (O) NHCH_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-4 4-C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three           G²-4 4-C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3-Cl-4-F-5-CF_Three             CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-5 −
3-Cl-4-F-5-CF_Three             CF_Three           G²-5 3-C (O) NH₂
3-Cl-4-F-5-CF_Three             CF_Three           G²-5 3-C (O) NHCH_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-5 3-C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three           G²-5 3-C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3-Cl-4-F-5-CF_Three             CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-6 4-C (O) NH₂
3-Cl-4-F-5-CF_Three             CF_Three           G²-6 4-C (O) NHCH_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-6 4-C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three           G²-6 4-C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3-Cl-4-F-5-CF_Three             CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-8 −
3-Cl-4-F-5-CF_Three             CF_Three           G²-9 −
3-Cl-4-F-5-CF_Three             CF_Three           G²-9 C (O) NH₂
3-Cl-4-F-5-CF_Three             CF_Three           G²-9 C (O) NHCH_Three
3-Cl-4-F-5-CF_Three             CF_Three           G²-9 C (O) NHEt
3-Cl-4-F-5-CF_Three             CF_Three           G²-9 C (O) NHPr-i
3-Cl-4-F-5-CF_Three             CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3-Cl-4-F-5-CF_Three             CF_Three           G²-9 C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Cl G²-5 −
3-Cl-4-F-5-CF_Three             CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Cl G²-8 −
3-Cl-4-F-5-CF_Three             CF₂Cl G²-9 −
3-Cl-4-F-5-CF_Three             CF₂Cl G²-9 C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂Br G²-2 3-C (O) NHCH₂CF_Three
3-Cl-4-F-5-CF_Three             CF₂CHF₂       G²-2 4-C (O) NHCH₂CF_Three
3,4-Cl₂-5-CF_Three              CF_Three           G²-5 −
3,5- (CF_Three)₂-4-Cl CHF₂          G²-5 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 3-C (O) NH₂
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 3-C (O) NHCH_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 3-C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 3-C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 3-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 4-C (O) NH₂
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 4-C (O) NHCH_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 4-C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 4-C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-3 4-C (O) NH₂
3,5- (CF_Three)₂-4-Cl CF_Three           G²-3 4-C (O) NHCH_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-3 4-C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three           G²-3 4-C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three           G²-3 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three           G²-3 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-4 4-C (O) NH₂
3,5- (CF_Three)₂-4-Cl CF_Three           G²-4 4-C (O) NHCH_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-4 4-C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three           G²-4 4-C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three           G²-4 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three           G²-4 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-5 −
3,5- (CF_Three)₂-4-Cl CF_Three           G²-5 3-C (O) NH₂
3,5- (CF_Three)₂-4-Cl CF_Three           G²-5 3-C (O) NHCH_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-5 3-C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three           G²-5 3-C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three           G²-5 3-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-6 4-C (O) NH₂
3,5- (CF_Three)₂-4-Cl CF_Three           G²-6 4-C (O) NHCH_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-6 4-C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three           G²-6 4-C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three           G²-6 4-C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three           G²-6 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-8 −
3,5- (CF_Three)₂-4-Cl CF_Three           G²-9 −
3,5- (CF_Three)₂-4-Cl CF_Three           G²-9 C (O) NH₂
3,5- (CF_Three)₂-4-Cl CF_Three           G²-9 C (O) NHCH_Three
3,5- (CF_Three)₂-4-Cl CF_Three           G²-9 C (O) NHEt
3,5- (CF_Three)₂-4-Cl CF_Three           G²-9 C (O) NHPr-i
3,5- (CF_Three)₂-4-Cl CF_Three           G²-9 C (O) NHCH₂CH₂Cl
3,5- (CF_Three)₂-4-Cl CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl G²-2 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl G²-2 4-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl G²-5 −
3,5- (CF_Three)₂-4-Cl CF₂Cl G²-5 3-C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Cl G²-8 −
3,5- (CF_Three)₂-4-Cl CF₂Cl G²-9 −
3,5- (CF_Three)₂-4-Cl CF₂Cl G²-9 C (O) NHCH₂CF_Three
3,5- (CF_Three)₂-4-Cl CF₂Br G²-8 −
3,5- (CF_Three)₂-4-Cl CF₂CHF₂       G²-9 −
3,5-Cl₂-4-OH CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Br₂-4-OH CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5-I₂-4-OH CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5-F₂-4-OCH_Three              CF_Three           G²-5 −
3,5-Cl₂-4-OCH_Three             CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3-F-5-Br-4-OCH_Three            CF_Three           G²-8 −
3-Cl-5-Br-4-OCH_Three           CF_Three           G²-9 −
3,5-Br₂-4-OCH_Three             CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂-4-OEt CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5-Br₂-4-OEt CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂-4-OPr-n CF_Three           G²-5 −
3,5-Cl₂-4-OCHF₂            CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5-Br₂-4-OCHF₂            CF_Three           G²-8 −
3,5-F₂-4-OCF_Three              CF_Three           G²-9 −
3,5-Cl₂-4-OCH₂CH = CH₂       CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂-4-OCH₂C≡CH CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5-Cl₂-4-OSi (CH_Three)_Three        CF_Three           G²-2 4-C (O) NHCH₂CF_Three
3,5-Cl₂-4-OSi (CH_Three)₂Bu-t CF_Three           G²-5 −
3,5-Cl₂-4-NH₂              CF_Three           G²-5 −
3,5-Cl₂-4-NH₂              CF_Three           G²-8 −
3,5-Br₂-4-NH₂              CF_Three           G²-5 −
3,5-Br₂-4-NH₂              CF_Three           G²-8 −
3,5-I₂-4-NH₂               CF_Three           G²-5 3-C (O) NHCH₂CF_Three
3,5-F₂-4-NO₂               CF_Three           G²-8 −
3,5-Cl₂-4-NO₂              CF_Three           G²-9 −
3,5-F₂-4-CN CF_Three           G²-9 C (O) NHCH₂CF_Three
3,5-Cl₂-4-CN CF_Three           G²-2 3-C (O) NHCH₂CF_Three
3,5-Br₂-4-CN CF_Three           G²-2 4-C (O) NHCH₂CF_Three
2,3,5,6-F_Four                 CF_Three           G²-5 −
2,3,4,5,6-F_Five               CF_Three           G²-5 3-C (O) NHCH₂CF_Three
―――――――――――――――――――――――――――――――――――――――
Table 3
  In the table, substituent (X)_m, (Y)_nAnd (Z^a)_pThe numbers representing the substitution positions correspond to the positions of the numbers described in the following structural formulas, and the symbol “-” represents no substitution.

At this time, the substituent G ¹ in the general formulas [2] -1 and [2] -2 represents a structure represented by the following G ¹ -1 to G ¹ -22, respectively.

The substituent G ² in the general formulas [2] -1 to [2] -4 represents a heterocycle represented by the following G ² -2 to G ² -9, respectively.

―――――――――――――――――――――――――――――――――――――――
G ¹ (X) _m (Y) _n G ² (Z ^a ) _p
―――――――――――――――――――――――――――――――――――――――
G ¹ -1 3-CF ₃ 2-Pr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ 2-OEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ 2-OPr-i G ² -5-
G ¹ -1 3-CF ₃ 2-OSO ₂ CH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ 2-SEt G ² -8 −
G ¹ -1 3-CF ₃ 2-SPr-i G ² -9 −
G ¹ -1 3-CF ₃ 2-NHEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ 2-NHPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ 2-N (CH ₃ ) ₂ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₂ CF ₃ 2-Pr-i G ² -5-
G ¹ -1 3-CF ₂ CF ₃ 2-OEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₂ CF ₃ 2-OPr-i G ² -8 −
G ¹ -1 3-CF ₂ CF ₃ 2-OSO ₂ CH ₃ G ² -9-
G ¹ -1 3-CF ₂ CF ₃ 2-SEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₂ CF ₃ 2-SPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₂ CF ₃ 2-NHEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₂ CF ₃ 2-NHPr-i G ² -5-
G ¹ -1 3-CF ₂ CF ₃ 2-N (CH ₃ ) ₂ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-SF ₅ 2-Pr-i G ² -8-
G ¹ -1 3-SF ₅ 2-OEt G ² -9 −
G ¹ -1 3-SF ₅ 2-OPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-SF ₅ 2-OSO ₂ CH ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-SF ₅ 2-SEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-SF ₅ 2-SPr-i G ² -5-
G ¹ -1 3-SF ₅ 2-NHEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-SF ₅ 2-NHPr-i G ² -8 −
G ¹ -1 3-SF ₅ 2-N (CH ₃ ) ₂ G ² -9 −
G ¹ -1 3,5-Cl ₂ 3-FG ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 3-Cl G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 3-Br G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 3-CH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 3-Et G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Pr-n G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-Pr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Pr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Pr-i G ² -5-
G ¹ -1 3,5-Cl ₂ 2-Pr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Pr-i G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-Pr-i G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-Pr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Bu-n G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-Bu-s G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Bu-t G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CF ₂ CF ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OH G ² -5-
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OCH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OCH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OPr-n G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OPr-i G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OPr-c G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ OCH ₂ CF ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ CH ₂ OCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SCH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SCH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-CH ₂ S (O) CH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SO ₂ CH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SCF ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SCF ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SCF ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SCF ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-CH ₂ S (O) CF ₃ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-CH ₂ SO ₂ CF ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-CH ₂ Ph G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ (D7-1a) G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ (D11-1a) G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₂ (D22-1a) G ² -5 −
G ¹ -1 3,5-Cl ₂ 3-OCH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OEt G ² -5-
G ¹ -1 3,5-Cl ₂ 2-OEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OEt G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-OEt G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-OEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OPr-n G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-OPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OPr-i G ² -5-
G ¹ -1 3,5-Cl ₂ 2-OPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OPr-i G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-OPr-i G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-OPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OBu-n G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-OPen-n G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OHex-n G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OCF ₂ Br G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OCF ₂ CHF ₂ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-OCF ₂ CHFCl G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OCF ₂ CHFCF ₃ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-OCF ₂ CHFOCF ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ CH ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ CH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ CH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ CH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ CH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ CH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ CH ₃ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ Et G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ Pr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OSO ₂ CF ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OPh G ² -5-
G ¹ -1 3,5-Cl ₂ 2-S (O) CH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SO ₂ CH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-SEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SEt G ² -5-
G ¹ -1 3,5-Cl ₂ 2-SEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SEt G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-SEt G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-SEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-S (O) Et G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-SO ₂ Et G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SPr-n G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-S (O) Pr-n G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SO ₂ Pr-n G ² -5-
G ¹ -1 3,5-Cl ₂ 2-SPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SPr-i G ² -5-
G ¹ -1 3,5-Cl ₂ 2-SPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SPr-i G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-SPr-i G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-SPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-S (O) Pr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SO ₂ Pr-i G ² -8-
G ¹ -1 3,5-Cl ₂ 2-S (O) CHF ₂ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-SO ₂ CHF ₂ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-S (O) CF ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SO ₂ CF ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SCF ₂ Br G ² -5-
G ¹ -1 3,5-Cl ₂ 2-S (O) CF ₂ Br G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SO ₂ CF ₂ Br G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-SCF ₂ CHFCl G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-S (O) CF ₂ CHFCl G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SO ₂ CF ₂ CHFCl G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-SPh G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-S (O) Ph G ² -5-
G ¹ -1 3,5-Cl ₂ 2-SO ₂ Ph G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHEt G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHEt G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-NHEt G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHPr-n G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHPr-n G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHPr-n G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHPr-n G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHPr-i G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHPr-i G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-NHPr-i G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) ₂ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) ₂ G ² -5 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) ₂ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) ₂ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) Et G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-N (Et) ₂ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHCHO G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHCHO G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHCHO G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHCHO G ² -9-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) CH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (O) CH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) CH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) CH ₃ G ² -9-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) Et G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (O) Pr-n G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (O) Pr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (O) Pr-c G ² -5 −
G ¹ -1 3,5-Cl ₂ 2-NHC (O) Bu-t G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (O) CF ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (O) CF ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) CF ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) CF ₃ G ² -9-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) OCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (O) OCH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) OCH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) OCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHC (O) OEt G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-NHC (O) SCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (O) SCH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) SCH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHC (O) SCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHC (O) SEt G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHC (S) OCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (S) OCH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHC (S) OCH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHC (S) OCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHC (S) OEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (S) SCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHC (S) SCH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHC (S) SCH ₃ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-NHC (S) SCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHC (S) SEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHSO ₂ CH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHSO ₂ CH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHSO ₂ CH ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHSO ₂ CH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-NHSO ₂ CF ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-NHSO ₂ CF ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-NHSO ₂ CF ₃ G ² -8-
G ¹ -1 3,5-Cl ₂ 2-NHSO ₂ CF ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) CHO G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) CHO G ² -5-
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) CHO G ² -8-
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) CHO G ² -9-
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) CH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Et G ² -5-
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Pr-n G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Pr-i G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Pr-c G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) Bu-t G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) CF ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) OCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) OEt G ² -5 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) SCH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (O) SEt G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (S) OCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (S) OEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (S) SCH ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) C (S) SEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) SO ₂ CH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) SO ₂ CF ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) CHO G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) CH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) Et G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) Pr-n G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) Pr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) Pr-c G ² -5 −
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) Bu-t G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) CF ₃ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) OCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) OEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) SCH ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (O) SEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (S) OCH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (S) OEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (S) SCH ₃ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-N (Et) C (S) SEt G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) SO ₂ CH ₃ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N (CH ₃ ) SO ₂ CF ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N = CHOCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N = C (CH ₃ ) OCH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-N = C (CH ₃ ) OCH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-N = C (CH ₃ ) OCH ₃ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-N = C (CH ₃ ) OCH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2- (D3-1a) G ² -5 −
G ¹ -1 3,5-Cl ₂ 2-C (O) OCH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-C (O) NH ₂ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2- (M7-1a) G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-C (S) NH ₂ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-C (S) NH ₂ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-C (S) NH ₂ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2-C (S) NH ₂ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2- (M9-1a) G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Ph G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2- (D7-1a) G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2- (D11-1a) G ² -5 −
G ¹ -1 3,5-Cl ₂ 2- (D22-1a) G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2- (D28-1a) G ² -8 −
G ¹ -1 3,5-Cl ₂ 2- (D28-1b) CH ₃ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2- (D29-1a) G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2- (D30-1a) HG ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2- (D30-1a) CH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2- (D31-1a) HG ² -5-
G ¹ -1 3,5-Cl ₂ 2- (D31-1a) CH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2,3-F ₂ G ² -8 −
G ¹ -1 3,5-Cl ₂ 2,5-F ₂ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2,6-F ₂ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-F-6-Cl G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-F-6-Br G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-F-6-CF ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-F-6-NO ₂ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Cl-3-FG ² -8-
G ¹ -1 3,5-Cl ₂ 2,3-Cl ₂ G ² -9 −
G ¹ -1 3,5-Cl ₂ 2-Cl-5-FG ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2,5-Cl ₂ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2,6-Cl ₂ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-Br-3-FG ² -5-
G ¹ -1 3,5-Cl ₂ 2-Br-5-FG ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -3-FG ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -3-FG ² -5-
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -3-FG ² -8-
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -3-FG ² -9-
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -3-Cl G ² -8-
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -5-FG ² -9-
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -5-Cl G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -6-FG ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -6-FG ² -5-
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -6-FG ² -8-
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -6-FG ² -9-
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -6-Cl G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2,6- (CH ₃ ) ₂ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CH ₃ -6-CF ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ 2-CF ₃ -5-FG ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CF ₃ -5-Cl G ² -8-
G ¹ -1 3,5-Cl ₂ 2-OCH ₃ -3-FG ² -9-
G ¹ -1 3,5-Cl ₂ 2-OCH ₃ -5-FG ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-OCH ₃ -5-Cl G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ 2-CN-3-FG ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-Br 2-Pr-i G ² -5-
G ¹ -1 3-Cl-5-Br 2-OEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-Br 2-OPr-i G ² -8-
G ¹ -1 3-Cl-5-Br 2-OSO ₂ CH ₃ G ² -9 −
G ¹ -1 3-Cl-5-Br 2-SEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-Br 2-SPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-Br 2-NHEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-Br 2-NHPr-i G ² -5-
G ¹ -1 3-Cl-5-Br 2-N (CH ₃ ) ₂ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ 2-Pr-i G ² -8 −
G ¹ -1 3,5-Br ₂ 2-OEt G ² -9 −
G ¹ -1 3,5-Br ₂ 2-OPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ 2-OSO ₂ CH ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ 2-SEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ 2-SPr-i G ² -5-
G ¹ -1 3,5-Br ₂ 2-NHEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ 2-NHPr-i G ² -8 −
G ¹ -1 3,5-Br ₂ 2-N (CH ₃ ) ₂ G ² -9 −
G ¹ -1 3-Cl-5-I 2-Pr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-I 2-OEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-I 2-OPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-I 2-OSO ₂ CH ₃ G ² -5 −
G ¹ -1 3-Cl-5-I 2-SEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-I 2-SPr-i G ² -8-
G ¹ -1 3-Cl-5-I 2-NHEt G ² -9 −
G ¹ -1 3-Cl-5-I 2-NHPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-I 2-N (CH ₃ ) ₂ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-F 2-Pr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-F 2-OEt G ² -5-
G ¹ -1 3-CF ₃ -4-F 2-OPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-F 2-OSO ₂ CH ₃ G ² -8-
G ¹ -1 3-CF ₃ -4-F 2-SEt G ² -9-
G ¹ -1 3-CF ₃ -4-F 2-SPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-F 2-NHEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-F 2-NHPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-F 2-N (CH ₃ ) ₂ G ² -5-
G ¹ -1 3-F-5-CF ₃ 2-Pr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-F-5-CF ₃ 2-OEt G ² -8 −
G ¹ -1 3-F-5-CF ₃ 2-OPr-i G ² -9 −
G ¹ -1 3-F-5-CF ₃ 2-OSO ₂ CH ₃ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-F-5-CF ₃ 2-SEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-F-5-CF ₃ 2-SPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-F-5-CF ₃ 2-NHEt G ² -5 −
G ¹ -1 3-F-5-CF ₃ 2-NHPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-F-5-CF ₃ 2-N (CH ₃ ) ₂ G ² -8 −
G ¹ -1 3-CF ₃ -4-Cl 2-Pr-i G ² -9-
G ¹ -1 3-CF ₃ -4-Cl 2-OEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-Cl 2-OPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-Cl 2-OSO ₂ CH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-Cl 2-SEt G ² -5-
G ¹ -1 3-CF ₃ -4-Cl 2-SPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-CF ₃ -4-Cl 2-NHEt G ² -8-
G ¹ -1 3-CF ₃ -4-Cl 2-NHPr-i G ² -9-
G ¹ -1 3-CF ₃ -4-Cl 2-N (CH ₃ ) ₂ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-CF ₃ 2-Pr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-CF ₃ 2-OEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-CF ₃ 2-OPr-i G ² -5-
G ¹ -1 3-Cl-5-CF ₃ 2-OSO ₂ CH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-CF ₃ 2-SEt G ² -8 −
G ¹ -1 3-Cl-5-CF ₃ 2-SPr-i G ² -9 −
G ¹ -1 3-Cl-5-CF ₃ 2-NHEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-CF ₃ 2-NHPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-5-CF ₃ 2-N (CH ₃ ) ₂ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Br-5-CF ₃ 2-Pr-i G ² -5-
G ¹ -1 3-Br-5-CF ₃ 2-OEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Br-5-CF ₃ 2-OPr-i G ² -8 −
G ¹ -1 3-Br-5-CF ₃ 2-OSO ₂ CH ₃ G ² -9 −
G ¹ -1 3-Br-5-CF ₃ 2-SEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-Br-5-CF ₃ 2-SPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Br-5-CF ₃ 2-NHEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Br-5-CF ₃ 2-NHPr-i G ² -5-
G ¹ -1 3-Br-5-CF ₃ 2-N (CH ₃ ) ₂ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ 2-Pr-i G ² -8 −
G ¹ -1 3,5- (CF ₃ ) ₂ 2-OEt G ² -9 −
G ¹ -1 3,5- (CF ₃ ) ₂ 2-OPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ 2-OSO ₂ CH ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ 2-SEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ 2-SPr-i G ² -5 −
G ¹ -1 3,5- (CF ₃ ) ₂ 2-NHEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ 2-NHPr-i G ² -8 −
G ¹ -1 3,5- (CF ₃ ) ₂ 2-N (CH ₃ ) ₂ G ² -9 −
G ¹ -1 3,5-Cl ₂ -4-F 2-Pr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ -4-F 2-OEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ -4-F 2-OPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ -4-F 2-OSO ₂ CH ₃ G ² -5-
G ¹ -1 3,5-Cl ₂ -4-F 2-SEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ -4-F 2-SPr-i G ² -8-
G ¹ -1 3,5-Cl ₂ -4-F 2-NHEt G ² -9-
G ¹ -1 3,5-Cl ₂ -4-F 2-NHPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Cl ₂ -4-F 2-N (CH ₃ ) ₂ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,4,5-Cl ₃ 2-Pr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1, 3,4,5-Cl ₃ 2-OEt G ² -5-
G ¹ -1 3,4,5-Cl ₃ 2-OPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1, 3,4,5-Cl ₃ 2-OSO ₂ CH ₃ G ² -8 −
G ¹ -1, 3,4,5-Cl ₃ 2-SEt G ² -9 −
G ¹ -1 3,4,5-Cl ₃ 2-SPr-i G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,4,5-Cl ₃ 2-NHEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,4,5-Cl ₃ 2-NHPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1, 3,4,5-Cl ₃ 2-N (CH ₃ ) ₂ G ² -5 −
G ¹ -1 3,5-Br ₂ -4-F 2-Pr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ -4-F 2-OEt G ² -8-
G ¹ -1 3,5-Br ₂ -4-F 2-OPr-i G ² -9-
G ¹ -1 3,5-Br ₂ -4-F 2-OSO ₂ CH ₃ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ -4-F 2-SEt G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ -4-F 2-SPr-i G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ -4-F 2-NHEt G ² -5-
G ¹ -1 3,5-Br ₂ -4-F 2-NHPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5-Br ₂ -4-F 2-N (CH ₃ ) ₂ G ² -8-
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-Pr-i G ² -9-
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-OEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-OPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-OSO ₂ CH ₃ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-SEt G ² -5-
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-SPr-i G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-NHEt G ² -8-
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-NHPr-i G ² -9-
G ¹ -1 3,4-F ₂ -5-CF ₃ 2-N (CH ₃ ) ₂ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-Pr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-OEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-OPr-i G ² -5-
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-OSO ₂ CH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-SEt G ² -8-
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-SPr-i G ² -9-
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-NHEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-NHPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3-Cl-4-F-5-CF ₃ 2-N (CH ₃ ) ₂ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-Pr-i G ² -5-
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-OEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-OPr-i G ² -8-
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-OSO ₂ CH ₃ G ² -9-
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-SEt G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-SPr-i G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-NHEt G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-NHPr-i G ² -5-
G ¹ -1 3,5- (CF ₃ ) ₂ -4-Cl 2-N (CH ₃ ) ₂ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -3 5-Cl − G ² -8 −
G ¹ -3 5-CF ₃ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -3 5-CF ₃ − G ² -5 −
G ¹ -3 5-CF ₃ − G ² -8 −
G ¹ -3 5-CF ₃ − G ² -9 −
G ¹ -3 5-CF ₃ -6-Cl − G ² -9 −
G ¹ -3 5-NO ₂ -6-Cl-G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -4 2-Cl-G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -4 2-Br-G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2-CF ₃ -G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2-CF ₃ − G ² -5 −
G ¹ -4 2-CF ₃ − G ² -8 −
G ¹ -4 2-CF ₃ − G ² -9 −
G ¹ -4 2,6-F ₂ − G ² -5 −
G ¹ -4 2,6-Cl ₂ − G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ − G ² -2 4-C (O) NH ₂
G ¹ -4 2,6-Cl ₂ − G ² -2 4-C (O) NHCH ₃
G ¹ -4 2,6-Cl ₂ -G ² -2 4-C (O) NHEt
G ¹ -4 2,6-Cl ₂ -G ² -2 4-C (O) NHPr-i
G ¹ -4 2,6-Cl ₂ − G ² -2 4-C (O) NHCH ₂ CH ₂ Cl
G ¹ -4 2,6-Cl ₂ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ − G ² -3 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ − G ² -4 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ − G ² -5 −
G ¹ -4 2,6-Cl ₂ − G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ − G ² -6 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ − G ² -8 −
G ¹ -4 2,6-Cl ₂ − G ² -9 −
G ¹ -4 2,6-Cl ₂ − G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-FG ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-Cl G ² -8-
G ¹ -4 2,6-Cl ₂ 2-Br G ² -9-
G ¹ -4 2,6-Cl ₂ 2-IG ² -9 C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-CH ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-Et G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-CF ₃ G ² -5-
G ¹ -4 2,6-Cl ₂ 2-OCH ₃ G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-OCHF ₂ G ² -8 −
G ¹ -4 2,6-Cl ₂ 2-OCF ₃ G ² -9 −
G ¹ -4 2,6-Cl ₂ 2-SCH ₃ G ² -9 C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-SCF ₃ G ² -2 3-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-NO ₂ G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Cl ₂ 2-NHCH ₃ G ² -5-
G ¹ -4 2,6-Cl ₂ 2-NHEt G ² -5 3-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Br ₂ -G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6-Br ₂ − G ² -5 −
G ¹ -4 2,6-Br ₂ − G ² -8 −
G ¹ -4 2,6-Br ₂ − G ² -9 −
G ¹ -4 2-Br-6-CF ₃ -G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2-Br-6-CF ₃ − G ² -5 −
G ¹ -4 2-Br-6-CF ₃ − G ² -8 −
G ¹ -4 2-Br-6-CF ₃ − G ² -9 −
G ¹ -4 2,6- (CF ₃ ) ₂ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -4 2,6- (CF ₃ ) ₂ − G ² -5 −
G ¹ -4 2,6- (CF ₃ ) ₂ − G ² -8 −
G ¹ -4 2,6- (CF ₃ ) ₂ − G ² -9 −
G ¹ -13 4-CF ₃ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -13 4-CF ₃ − G ² -5 −
G ¹ -13 4-CF ₃ − G ² -8 −
G ¹ -13 4-CF ₃ − G ² -9 −
G ¹ -13 5-CF ₃ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -13 5-CF ₃ − G ² -5 −
G ¹ -13 5-CF ₃ − G ² -8 −
G ¹ -13 5-CF ₃ − G ² -9 −
G ¹ -13 4,5-Cl ₂ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -13 4,5-Cl ₂ − G ² -5 −
G ¹ -13 4,5-Cl ₂ − G ² -8 −
G ¹ -13 4,5-Cl ₂ − G ² -9 −
G ¹ -13 4-Cl-5-Br − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -13 4-Cl-5-Br − G ² -5 −
G ¹ -13 4-Cl-5-Br − G ² -8 −
G ¹ -13 4-Cl-5-Br − G ² -9 −
G ¹ -13 4-Br-5-Cl − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -13 4-Br-5-Cl − G ² -5 −
G ¹ -13 4-Br-5-Cl − G ² -8 −
G ¹ -13 4-Br-5-Cl − G ² -9 −
G ¹ -13 4,5-Br ₂ -G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -13 4,5-Br ₂ − G ² -5 −
G ¹ -13 4,5-Br ₂ − G ² -8 −
G ¹ -13 4,5-Br ₂ − G ² -9 −
G ¹ -14 5-CF ₃ -G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -14 5-CF ₃ − G ² -5 −
G ¹ -14 5-CF ₃ − G ² -8 −
G ¹ -14 5-CF ₃ − G ² -9 −
G ¹ -17a 5-CF ₃ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -17a 5-CF ₃ − G ² -5 −
G ¹ -17a 5-CF ₃ − G ² -8 −
G ¹ -17a 5-CF ₃ − G ² -9 −
G ¹ -20 4-CF ₃ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -20 4-CF ₃ − G ² -5 −
G ¹ -20 4-CF ₃ − G ² -8 −
G ¹ -20 4-CF ₃ − G ² -9 −
G ¹ -20 5-CF ₃ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -20 5-CF ₃ − G ² -5 −
G ¹ -20 5-CF ₃ − G ² -8 −
G ¹ -20 5-CF ₃ − G ² -9 −
G ¹ -21 2-CF ₃ − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -21 2-CF ₃ − G ² -5 −
G ¹ -21 2-CF ₃ − G ² -8 −
G ¹ -21 2-CF ₃ − G ² -9 −
G ¹ -22 2-Cl − G ² -2 4-C (O) NHCH ₂ CF ₃
G ¹ -22 2-Cl − G ² -5 −
G ¹ -22 2-Cl − G ² -8 −
G ¹ -22 2-Cl − G ² -9 −
―――――――――――――――――――――――――――――――――――――――
Table 4 In the table, the numbers representing the substitution positions of the substituent (Z ^a ) _p correspond to the positions of the numbers described in the above structural formula, respectively, and the notation of − indicates no substitution. To express.

At this time, the substituent G ² in the general formulas [3] -1 to [3] -48 represents a heterocycle represented by the following G ² -2 to G ² -9, respectively.

―――――――――――――――――― ――――――――――――――――――
G ² (Z ^a ) _p G ² (Z ^a ) _p
―――――――――――――――――― ――――――――――――――――――
G ² -2 3-CN G ² -5 −
G ² -2 3-C (O) NH ₂ G ² -5 3-NO ₂
^{G 2 -2 3-C (O} ) NHCH 3 G 2 -5 3-CN
G ² -2 3-C (O) N (CH ₃ ) ₂ G ² -5 3-C (O) NH ₂
G ² -2 3-C (O) NHEt G ² -5 3-C (O) NHCH ₃
G ² -2 3-C (O) NHPr-n G ² -5 3-C (O) N (CH ₃ ) ₂
G ² -2 3-C (O) NHPr-i G ² -5 3-C (O) NHEt
G ² -2 3-C (O) NHPr-c G ² -5 3-C (O) NHPr-n
G ² -2 3-C (O) NHCH ₂ CH ₂ FG ² -5 3-C (O) NHPr-i
G ² -2 3-C (O) NHCH ₂ CH ₂ Cl G ² -5 3-C (O) NHPr-c
G ² -2 3-C (O) NHCH ₂ CF ₃ G ² -5 3-C (O) NHCH ₂ CH ₂ F
G ² -2 3-C (O) NHCH ₂ CN G ² -5 3-C (O) NHCH ₂ CH ₂ Cl
^{G 2 -2 3-C (O} ) NHCH 2 CH = CH 2 G 2 -5 3-C (O) NHCH 2 CF 3
G ² -2 3-C (O) NHCH ₂ C≡CH G ² -5 3-C (O) NHCH ₂ CN
G ² -2 4-CN G ² -5 3-C (O) NHCH ₂ CH = CH ₂
G ² -2 4-C (O) NH ₂ G ² -5 3-C (O) NHCH ₂ C≡CH
G ² -2 4-C (O) NHCH ₃ G ² -5 3-C (S) NH ₂
G ² -2 4-C (O) N (CH ₃ ) ₂ G ² -5 3-C (S) NHCH ₂ CF ₃
G ² -2 4-C (O) NHEt G ² -5 5-C (O) NH ₂
G ² -2 4-C (O) NHPr-n G ² -5 3-CN-5-CH ₃
G ² -2 4-C (O) NHPr-i G ² -5 3-C (O) NH ₂ -5-CH ₃
G ² -2 4-C (O) NHPr-c G ² -6 4-CN
^{G 2 -2 4-C (O} ) NHCH 2 CH 2 FG 2 -6 4-C (O) NH 2
G ² -2 4-C (O) NHCH ₂ CH ₂ Cl G ² -6 4-C (O) NHCH ₃
G ² -2 4-C (O) NHCH ₂ CF ₃ G ² -6 4-C (O) N (CH ₃ ) ₂
G ² -2 4-C (O) NHCH ₂ CN G ² -6 4-C (O) NHEt
G ² -2 4-C (O) NHCH ₂ CH = CH ₂ G ² -6 4-C (O) NHPr-n
G ² -2 4-C (O) NHCH ₂ C≡CH G ² -6 4-C (O) NHPr-i
G ² -2 4-C (S) NH ₂ G ² -6 4-C (O) NHPr-c
G ² -2 4-C (S) NHCH ₂ CF ₃ G ² -6 4-C (O) NHCH ₂ CH ₂ F
G ² -3 4-CN G ² -6 4-C (O) NHCH ₂ CH ₂ Cl
G ² -3 4-C (O) NH ₂ G ² -6 4-C (O) NHCH ₂ CF ₃
^{G 2 -3 4-C (O} ) NHCH 3 G 2 -6 4-C (O) NHCH 2 CN
G ² -3 4-C (O) N (CH ₃ ) ₂ G ² -6 4-C (O) NHCH ₂ CH = CH ₂
G ² -3 4-C (O) NHEt G ² -6 4-C (O) NHCH ₂ C≡CH
G ² -3 4-C (O) NHPr-n G ² -7 −
G ² -3 4-C (O) NHPr-i G ² -7 −
G ² -3 4-C (O) NHPr-c G ² -8 −
G ² -3 4-C (O) NHCH ₂ CH ₂ FG ² -8 Cl
G ² -3 4-C (O) NHCH ₂ CH ₂ Cl G ² -8 CH ₃
G ² -3 4-C (O) NHCH ₂ CF ₃ G ² -8 CH ₂ CN
G ² -3 4-C (O) NHCH ₂ CN G ² -8 CN
^{G 2 -3 4-C (O} ) NHCH 2 CH = CH 2 G 2 -9 -
G ² -3 4-C (O) NHCH ₂ C≡CH G ² -9 CN
G ² -4 − G ² -9 C (O) NH ₂
G ² -4 4-CN G ² -9 C (O) NHCH ₃
G ² -4 4-C (O) NH ₂ G ² -9 C (O) N (CH ₃ ) ₂
G ² -4 4-C (O) NHCH ₃ G ² -9 C (O) NHEt
G ² -4 4-C (O) N (CH ₃ ) ₂ G ² -9 C (O) NHPr-n
G ² -4 4-C (O) NHEt G ² -9 C (O) NHPr-i
G ² -4 4-C (O) NHPr-n G ² -9 C (O) NHPr-c
G ² -4 4-C (O) NHPr-i G ² -9 C (O) NHCH ₂ CH ₂ F
^{G 2 -4 4-C (O} ) NHPr-c G 2 -9 C (O) NHCH 2 CH 2 Cl
G ² -4 4-C (O) NHCH ₂ CH ₂ FG ² -9 C (O) NHCH ₂ CF ₃
G ² -4 4-C (O) NHCH ₂ CH ₂ Cl G ² -9 C (O) NHCH ₂ CN
G ² -4 4-C (O) NHCH ₂ CF ₃ G ² -9 C (O) NHCH ₂ CH = CH ₂
G ² -4 4-C (O) NHCH ₂ CN G ² -9 C (O) NHCH ₂ C≡CH
G ² -4 4-C (O) NHCH ₂ CH = CH ₂ G ² -9 C (S) NH ₂
G ² -4 4-C (O) NHCH ₂ C≡CH G ² -9 C (S) NHCH ₂ CF ₃
―――――――――――――――――― ――――――――――――――――――
The compounds of the present invention are stored in warehouses, so-called agricultural pests that harm agricultural and horticultural crops and trees, so-called livestock pests that parasitize livestock and poultry, so-called sanitary pests that cause various adverse effects in the human living environment such as houses. It is possible to effectively control insects such as so-called stored grain pests that harm cereals and the like, and pests such as mites, crustaceans, molluscs, and nematodes that occur and harm in similar situations at low concentrations.

Specific examples of insects, mites, crustaceans, molluscs and nematodes that can be controlled using the compounds of the present invention include:
Adoxophyes honmai, Adoxophyes orana faciata, Archips breviplicanus, Archips fuscocupreanus, Grapholita molesta, Chama magnan Leguminivora glycinivorella), Matsumuraeses phaseoli, Pandemis heparana, Bucculatrix pyrivorella, Lyonetia clerkella, Lyonetia prunifal ringoniella), mandarin leaf moth (Phyllocnistis citrella), green moth (Acrolepiopsis sapporensis), wild moth (Acrolepiopsis suzukiella), black moth (Plutella xylostella), oyster leaf moth (Stathmopoda masinissa), cystogram tria ora gossypiella), peach sinker moth (Carposina sasakii), codling moth (Cydla pomonella), green moth (Chilo suppressalis), corn borer (Cnaphalocrocis medinalis), peach moth (Conogethes punctiferalis), cotton moth (Dia) (Etiella zinckenella), Glyphodes pyloalis, Hellula undalis, Ostrinia furnacalis, Ostrinia scapulalis, European corn borer (Ostrinia nubilaliseter, Pesta pal) ), White-tailed butterfly (Pieris brassicae), white-tailed butterfly (Pieris rapae crucivora), mugwort (Ascotis selenaria), soy bean looper (Pseudoplusia includens), chadokuga (Euproctis pseudoconspersa), maimaiga (Lymantria disparia), thymeina ), White-spotted starfish (Hyphantria cunea), white-spotted starfish (Lemyra imparilis), Akebiko-no-ha (Adris tyrannus), red-footed butterfly (Aedia leucomelas), red-footed squirrel (Agrotis ipsilon), red-tailed squirrel (Agrotis segetum) Uwaba (Ctenoplusia agnata), Helicoverpa armigera, Tobacco moth (Helicoverpa assulta), Cotton ball worm (Helicoverpa zea), Tobacco bad worm (Heliothis virescens), Mamestra brassicae, Mythimna naa ), Southern army worm (Spodoptera eridania), Spodoptera exigua, Fall army worm (Spodoptera frugiperda), Cotton leaf worm (Spodoptera littoralis), Spodoptera litura, Spodoptera litura, Spodoptera era ), Leeb Berry Moss (Endopiza viteana), tomato horn worm (Manduca quinquemaculata), tobacco horn worm (Manduca sexta) lepidopteran insects such as,
Thrips thrips (Frankliniella intonsa), Citrus thrips (Frankliniella occidentalis), Croton thrips (Prithia thrips) The total insect of the
Spotted beetle (Dolycoris baccarum), sea turtle (Eurydema rugosum), bark beetle (Eysarcoris aeneus), horseshoe beetle (Eysarcoris lewisi), white-headed beetle (Eysarcoris ventralis), subtilus , Nezara antennata, Nezara viridula, Piezodorus hybneri, Plautia crossota, Scotinophora lurida, tiger C Stink bug (Leptocorisa chinensis), Hoso-heli beetle (Riptortus clavatus), Red-headed beetle (Rhopalus msculatus), Cavelerius saccharivorus, Toba hemipterus cus, Togo hemipterus (Stephanitis pyrioides), Kuroto Bikasumi turtle (Halticus insularis), Turned plant bug (Lygus lineolaris), Nagamu sika turtle (Stenodema sibiricum), Akasika sika turtle (Stenotus rubrovittatus), Rice moss turtle (Trigonotylus caelestialium), ical Arisbori dia Green leafhopper (Balclutha saltuella), butterfly leafhopper (Epiacanthus stramineus), potato leaf hopper (Empoasca fabae), oyster leafhopper (Empoasca nipponica), Chanomidorimempei (Empoasca onukii), omenosaka ), Leafhopper leafhopper (Macrosteles striifrons), leafhopper leafhopper (Nephotettix cinctinceps), cotton-free hopper (Psuedatomoscelis seriatus), leafhopper (Laodelphax striatella), leafhopper (Nilaparvata lugens) Psylla pyrisuga, Aleurocanthus spiniferus, Silver leaf whitefly (Bemisia argentifolii), Tobacco whitefly (Bemisia tabaci), Citrus whitefly (Dialeurodes citri), Onsitsuna whitefly (trialeurous grape rum, Trialeurodes vapor Cotton Aphid (Aphis gossypii), Snowy Aphid (Aphis spiraecola), Peach Aphid (Myzus persicae), Komikan Aphid (Toxoptera aurantii), Alaska Scale Aphid (Drosicha corpulenta), Iceria scale P solani), citrus scale insect (Planococcus citri), stag beetle scale (Planococcus kuraunhiae), stag beetle scale (Pseudococcus comstocki), horn beetle (Ceroplastes ceriferus), ruby rotum (Ceroplastes rubens), red scallop Nymphalidae (Comstockaspis perniciosa), tea scale (Fiorinia theae), chanomarine scale insect (Pseudaonidia paeoniae), stag beetle (Pseudaulacaspis pentagona), scallop scale (Pseudaulacaspis prunicola), euglena (Unaspis yanonensis), Hemiptera insects such as Cimex lectularius,
Douganebubui (Anomala cuprea), Japanese common squirrel (Anomala rufocuprea), Core ohanamuri (Gametis jucunda), Nagachakogane (Heptophylla picea), Japanese beetle (Popillia japonica), Colorado potato beetle (Lepinotarsa decemlineata) White-footed beetle (Melanotus tamsuyensis), Tobacco beetle (Lasioderma serricorne), Himetaketakekisui (Epuraea domina), Green beetle (Epilachna varivestis), Nijuya-hoshi-tento (Epilachna vigintioctopunctata), T. Tribolium castaneum, Anoplophora malasiaca, Monochamus alternatus, Psacothea hilaris, Xylotrechus pyrrhoderus, callosobruchus, Callosobruchus Western Root beetle (Chaetocnema concinna), Southern corn root worm (Diabrotica undecimpunctata), Western corn root worm (Diabrotica virgifera), Northern corn root worm (Diabrotica barberi), Inedro beetle (Oulema oryzae), Phyllotreta nastriatum, Phyllotreta striol Tobet beetle (Psylliodes angusticollis), peach weevil (Rhynchites heros), aphid weevil (Cylas formicarius), cotton weevil (Anthonomus grandis), weevil (Echinocnemus squameus), weevil (Euscepes postfasciatus) Rice weevil (Lissohoptrus oryzophilus), horned weevil (Otiorhynchus sulcatus), granary weevil (Sitophilus granarius), hornet weevil (Sitophilus zeamais), bark weevil (Sphenophorus venatus vestitus moth) erus fuscipes), etc.
Soybean flies (Asphondylia yushimai), mud wings (Sitodiplosis mosellana), fruit flies (Bactrocera cucurbitae), citrus fruit flies (Bactrocera dorsalis), citrus fruit flies (Ceratitis capitata), rice moth flies Leafhopper (Agromyza oryzae), Leafworm (Chromatomyia horticola), Eggplant leaffly (Liriomyza bryoniae), Leafhopper (Liriomyza chinensis), Tomato leaffly (Liriomyza sativae), Beanworm (Liriomyza trifoli), Liriomyza trifoli (Pegomya cunicularia), apple haggot (Rhagoletis pomonella), hessian fly (Mayetiola destructor), housefly (Musca domestica), barn fly (Stomoxys calcitrans), sheep flies (Melophagus ovinus), bullflies (Hypoderma bovisma), , Sheep flies (Oestrus ovis), tsetse flies (Glossina palpalis, Glossina morsitans), black-headed ayu (Prosimulium yezoensis), bullfly (Tabanus trigonus), giant fly (Telmatoscopus albipunctatus), nipponen sip (Leptocons) Diptera, such as Aedes aegypti), Aedes albopicutus, Anopheles hyracanus sinesis,
Bumblebee (Apethymus kuri), Bumblebee (Athalia rosae), Bumblebee (Arge pagana), Bumblebee (Neodiprion sertifer), Bumblebee (Dryocosmus kuriphilus), Gantai (Eciton burchelli, Eciton schmitus), Eciton burchelli, Eciton schmitus mandarina), bulldog ant (Myrmecia spp.), fire ant (Solenopsis spp.), pharaoh ant (Monomorium pharaonis), etc.
Straight-legged insects, such as Telemacrylus emma, Kera (Gryllotalpa orientalis), Tosama grasshopper (Locusta migratoria), Oxya yezoensis, Sabaquat grasshopper (Schistocerca gregaria),
Coleoptera insects such as the white-headed beetle (Onychiurus folsomi), the Siberian white-headed beetle (Onychiurus sibiricus), the Bourletiella hortensis,
Reticulate insects such as black cockroach (Periplaneta fuliginosa), cockroach (Periplaneta japonica), German cockroach (Blattella germanica),
Termite insects such as the termites (Coptotermes formosanus), Yamato termites (Reticulitermes speratus), Taiwan termites (Odontotermes formosanus),
Insect insects such as cat fleas (Ctenocephalidae felis), dog fleas (Ctenocephalides canis), chicken fleas (Echidnophaga gallinacea), human fleas (Pulex irritans), keops rat fleas (Xenopsylla cheopis),
Insects such as chicken lice (Menacanthus stramineus) and bovine lice (Bovicola bovis),
Lice insects such as cattle lice (Haematopinus eurysternus), pig lice (Haematopinus suis), cattle white lice (Linognathus vituli), horned lice (Solenopotes capillatus),
Dust mites such as cyclamen dust mite (Phytonemus pallidus), chano dust mite (Polyphagotarsonemus latus), red mite dust mite (Tarsonemus bilobatus),
Spider mites (Penthaleus erythrocephalus), wheat mites (Penthaleus major), etc.
Spider mites such as rice spider mite (Oligonychus shinkajii), citrus spider mite (Panonychus citri), blue spider mite (Panonychus mori), apple spider mite (Panonychus ulmi), Kanzawa spider mite (Tetranychus kanzawai), spider mite (Tetranychus urticae), etc.
Chinese cabbage mite (Acaphylla theavagrans), tulip rust mite (Aceria tulipae), tomato rust mite (Aculops lycopersici), citrus red mite (Aculops pelekassi), apple rust mite (Aculus schlechtendali), black rust mite (Eriophyes chitrastrostrum) ), Etc.,
Acarids such as robin mite (Rhizoglyphus robini), mushroom mite (Tyrophagus putrescentiae), spinach mushroom mite (Tyrophagus similis),
Bee mites such as honeybee mite (Varroa jacobsoni),
Tick tick (Boophilus microplus), Rhipicephalus sanguineus, Tick tick (Haemaphysalis longicornis), Tick tick (Haemophysalis flava), Tick tick (Haemophysalis campanulata), Tick tick (Ixo tus tick) Amblyomma spp.), Ticks such as Dermacentor spp.
Claw mites (Cheyletiella yasguri), claw mites (Cheyletiella blakei),
Acne mites, such as Inodecarid mites (Demodex canis), Caterpillar mites (Demodex cati),
Cucumber mites such as sheep cucumber mites (Psoroptes ovis),
Spider mites, such as Sarcoptes scabiei, Caterpillar spider mite (Notoedres cati), Chicken spider mite (Knemidocoptes spp.),
Crustaceans such as the armadillum (Armadillidium vulgare),
Gastropods such as Pomacea canaliculata, African mussel (Achatina fulica), Slug (Meghimatium bilineatum), Chaukoura slug (Limax Valentiana), Uskawamai (Acusta despecta sieboldiana), Mishamai mai (Euhadra peliomphala), etc.
Southern nematode nematode (Prathylenchus coffeae), Kitane-negususa nematode (Prathylenchus penetrans), Kurume rushes nematode (Prathylenchus vulnus), potato cyst nematode (Globodera rostochiensis), soybean cyst nematode (Heterodera lypter Nematodes such as root-knot nematode (Meloidogyne incognita), rice-spotted nematode (Aphelenchoides besseyi), pine wood nematode (Bursaphelenchus xylophilus),
However, the present invention is not limited to these examples.

In addition, specific examples of endoparasites such as livestock, poultry, and pet animals that can be controlled using the present compound include
Haemonchus, Trichostrongylus, Ostertagia, Nematodirus, Cooperia, Ascaris, Bunostomum, Esphagotome Genus (Oesophagostomum), Chabertia, Trichuris, Storongylus, Trichonema, Dictyocaulus, Capillaria, Heterakis ), Toxocara, Ascaridia, Oxyuris, Ancylostoma, Uncinaria, Toxacaris, Parascaris and other nematodes ,
Filariidae nematodes such as Wuchereria, Blueia, Onchoceca, Dirofilaria, Loa
Dracunculidae nematodes such as the genus Deacunculus,
Dogworms (Dipylidium caninum), caterpillars (Taenia taeniaeformis), rodents (Taenia solium), striped tapeworms (Taenia saginata), contracted tapeworms (Hymenolepis diminuta), Benedenta (Moniezia benedeni), Tapeworms such as Diphyllobothrium latum, Manson cleftworm (Diphyllobothrium erinacei), Echinococcus granulosus, Echinococcus multilocularis,
Fasciola hepatica (F. gigantica), Westermann lung fluke (Paragonimus westermanii), hypertrophic fluke (Fasciolopsic bruski), pancreatic fluke (Eurytrema pancreaticum, E. coelomaticum), liver fluke (Clonorchis sinensis), Schistosoma Schistosoma japonicum), Schistosoma haematobium, Schistosoma mansoni, etc.,
Eimeria tenella, Eimeria acervulina, Eimeria brunetti, Eimeria maxima, Eimeria necatrix, Eimeria bovis, Eimeria bovis Eimeria spp., Such as Eimeria ovinoidalis,
Trypanosomsa cruzi, Leishmania spp., Plasmodium spp., Babesis spp., Trichomonadidae spp., Histomanas spp., Giardia (Giardia spp.), Toxoplasma spp., Entamoeba histolytica, Theileria spp.,
However, the present invention is not limited to these examples.

  Furthermore, the compound of the present invention is also effective against pests that have developed resistance to existing insecticides such as organophosphorus compounds, carbamate compounds, and pyrethroid compounds.

  That is, the compound of the present invention is composed of the order of mucous eyes (Coleoptera), reticulates (Roaches), straight moths (Grasshoppers), termites, common moths (Thrips), hemimorphs (stink bugs and leafhoppers). Eyes), Lepidoptera (Lepidoptera), Coleoptera (Coleoptera), Hymenoptera (Hymenoptera), Diptera (Flyidae), Islamic (Flea), Liceid, and other insects, ticks In addition, pests belonging to gastropods and nematodes can be effectively controlled at low concentrations. On the other hand, the compounds of the present invention are extremely useful with little adverse effect on mammals, fish, crustaceans and beneficial insects (beneficial insects such as bees and bumblebees, natural enemies such as honeybees, wasps, mistletoe flies, mosquitoes, and mites). Has features.

  When using the compound of the present invention, it is usually mixed with a suitable solid carrier or liquid carrier, and if desired, a surfactant, penetrant, spreading agent, thickener, antifreezing agent, binder, anti-caking agent. , Disintegrating agents, antifoaming agents, preservatives and anti-degradation agents, etc., and soluble concentrate, emulsion (emulsifiable concentrate), wettable powder, water-soluble powder, granular water Water dispersible granule, water soluble granule, suspension concentrate, concentrated emulsion, suspoemulsion, microemulsion, dustable powder ), Granule tablets, and emulsifiable gels, and can be put to practical use. Further, from the viewpoint of labor saving and safety improvement, the preparations of any of the above dosage forms can be provided by being enclosed in a water-soluble package such as a water-soluble capsule and a bag of a water-soluble film.

  Examples of the solid carrier include quartz, calcite, gypsum, dolomite, chalk, kaolinite, pyrophyllite, sericite, halosite, metahalosite, kibushi clay, glazed clay, porcelain stone, siegrite, and allophane. Natural minerals such as shirasu, kira, talc, bentonite, activated clay, acid clay, pumice, attapulgite, zeolite and diatomaceous earth, for example, calcined clay, perlite, shirasu balloon, vermiculite, attapulgus clay and calcined diatomaceous earth Baked products such as magnesium carbonate, calcium carbonate, sodium carbonate, sodium bicarbonate, ammonium sulfate, sodium sulfate, magnesium sulfate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate and potassium chloride, such as glucose, fructose , And Sugars such as sugar and lactose, polysaccharides such as starch, powdered cellulose and dextrin, organic materials such as urea, urea derivatives, benzoic acid and benzoic acid salts, such as wood flour, cork flour, corn cobs, walnut shells and Examples include plants such as tobacco stalks, fly ash, white carbon (for example, hydrous synthetic silica, anhydrous synthetic silica, hydrous synthetic silicate, etc.) and fertilizers.

Examples of the liquid carrier include xylene, alkyl (C ₉ or C ₁₀ etc.) benzene, phenyl xylyl ethane and alkyl (C ₁ or C ₃ etc.) naphthalene and other aromatic hydrocarbons, machine oil, normal paraffin, isoparaffin and Aliphatic hydrocarbons such as naphthene, mixtures of aromatic and aliphatic hydrocarbons such as kerosene, alcohols such as ethanol, isopropanol, cyclohexanol, phenoxyethanol and benzyl alcohol, ethylene glycol, propylene glycol, diethylene glycol, hexylene glycol , Polyhydric alcohols such as polyethylene glycol and polypropylene glycol, propyl cellosolve, butyl cellosolve, phenyl cellosolve, propylene glycol monomethyl ether, propylene Ethers such as recall monoethyl ether, propylene glycol monopropyl ether, propylene glycol monobutyl ether and propylene glycol monophenyl ether, ketones such as acetophenone, cyclohexanone and γ-butyrolactone, fatty acid methyl esters, dialkyl esters of succinic acid, dialkyl esters of glutamic acid, adipine esters such as dialkyl ester and dialkyl phthalate esters, N- alkyl (C _1, C ₈ or C _12, etc.) acid amide pyrrolidone, soybean oil, linseed oil, rapeseed oil, coconut oil, such as cottonseed oil and castor oil Examples include fats and oils, dimethyl sulfoxide and water.

  These solid and liquid carriers may be used alone or in combination of two or more.

  Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl (mono or di) phenyl ether, polyoxyethylene (mono, di or tri) styryl phenyl ether, polyoxyethylene polyoxypropylene block copolymer, polyoxyethylene Ethylene fatty acid (mono or di) ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, castor oil ethylene oxide adduct, acetylene glycol, acetylene alcohol, ethylene oxide adduct of acetylene glycol, ethylene oxide adduct of acetylene alcohol and alkyl Nonionic surfactants such as glycosides, alkyl sulfate esters, alkylbenzene sulfonates, lignin sulfonates, Killsulfosuccinate, naphthalenesulfonate, alkylnaphthalenesulfonate, salt of formalin condensate of naphthalenesulfonic acid, salt of formalin condensate of alkylnaphthalenesulfonic acid, polyoxyethylene alkyl ether sulfate or phosphate ester salt, polyoxy Ethylene (mono or di) alkyl phenyl ether sulfate or phosphate ester salt, polyoxyethylene (mono, di or tri) styryl phenyl ether sulfate or phosphate ester salt, polycarboxylate (eg polyacrylate, polymaleate and Copolymers of maleic acid and olefins, etc.) and anionic surfactants such as polystyrene sulfonates, cationic surfactants such as alkylamine salts and alkyl quaternary ammonium salts, amino acid types and beties Amphoteric surfactants such as mold, and silicone-based surfactants and fluorinated surfactants.

  The content of these surfactants is not particularly limited, but is usually preferably in the range of 0.05 to 20 parts by weight per 100 parts by weight of the preparation of the present invention. These surfactants may be used alone or in combination of two or more.

  The application amount of the compound of the present invention varies depending on the application scene, application time, application method, cultivated crops, etc., but generally 0.005 to 50 kg per hectare (ha) is appropriate as the amount of active ingredient.

  On the other hand, when using the compound of the present invention for the control of the ectoparasites of mammals and birds as domestic animals and pets, an effective amount of the compound of the present invention is administered orally together with injection additives (intramuscular, Parenteral administration such as subcutaneous, intravenous, intraperitoneal; transdermal administration such as immersion, spraying, bathing, washing, pouring-on and spotting-on and dusting; nasal administration Can be administered. The compounds of the present invention can also be administered by molded products using strips, plates, bands, collars, ear marks, limb bands, labeling devices and the like. In administration, the compound of the present invention can be in any dosage form suitable for the administration route.

  Arbitrary forms to be prepared include solid preparations such as powders, granules, wettable powders, pellets, tablets, large pills, capsules, molded products containing active compounds; injection solutions, oral solutions, skin Liquid preparations used above or in body cavities; solution preparations such as pour-on, spot-on, flowable, and emulsion; semi-solid preparations such as ointments and gels.

  The solid preparation can be used mainly for oral administration or diluted with water for transdermal administration or environmental treatment. Solid preparations can be prepared by adding the active compound, if necessary, with adjuncts, mixing with appropriate excipients, and converting to the desired shape. Suitable excipients include, for example, inorganic substances such as carbonates, bicarbonates, phosphates, aluminum oxides, silicas, clays, and organic substances such as sugars, cellulose, crushed grains, and starches.

  Injection solutions can be administered intravenously, intramuscularly and subcutaneously. Injection solutions dissolve the active compound in a suitable solvent and, if necessary, solubilizers, acids, bases, buffer salts, antioxidants. And can be prepared by adding additives such as protective agents. Suitable solvents include water, ethanol, butanol, benzyl alcohol, glycerin, propylene glycol, polyethylene glycol, N-methylpyrrolidone and mixtures thereof, physiologically acceptable vegetable oils, synthetic oils suitable for injection, and the like. Examples of solubilizers include polyvinylpyrrolidone, polyoxyethylated castor oil, and polyoxyethylated sorbitan ester. Protecting agents include benzyl alcohol, trichlorobutanol, p-hydroxybenzoic acid ester and n-butanol.

  Oral solutions can be administered directly or diluted. It can be prepared in the same manner as an injectable solution.

  Flowables, emulsions, etc. can be administered directly or diluted transdermally or by environmental treatment.

  Solutions for use on the skin can be administered by dripping, spreading, rubbing, spraying, spraying or applying by dipping (dipping, bathing or washing). These solutions can be prepared in the same manner as injection solutions.

  Pour-on and spot-on agents can be dripped or sprayed onto a limited area of the skin, so that the active compound can be immersed in the skin and act systemically . Drops and drop preparations can be prepared by dissolving, suspending or emulsifying the active ingredient in suitable skin-compatible solvents or solvent mixtures. If necessary, auxiliary agents such as surfactants, colorants, absorption promoting substances, antioxidants, light stabilizers and adhesives may be added.

  Suitable solvents include water, alkanol, glycol, polyethylene glycol, polypropylene glycol, glycerin, benzyl alcohol, phenylethanol, phenoxyethanol, ethyl acetate, butyl acetate, benzyl benzoate, dipropylene glycol monomethyl ether, diethylene glycol monobutyl ether, acetone, Methyl ethyl ketone, aromatic and / or aliphatic hydrocarbons, vegetable or synthetic oil, DMF, liquid paraffin, light liquid paraffin, silicone, dimethylacetamide, N-methylpyrrolidone or 2,2-dimethyl-4-oxy-methylene-1, 3-dioxolane is mentioned. Absorption enhancers include DMSO, isopropyl myristate, dipropylene glycol pelargonate, silicone oil, aliphatic esters, triglycerides and fatty alcohols. Antioxidants include sulfites, metabisulfites, ascorbic acid, butylhydroxytoluene, butylhydroxyanisole and tocopherol.

  The emulsion can be administered orally, transdermally or as an injection. In emulsions, the active ingredient is dissolved in a hydrophobic phase or a hydrophilic phase, and this is added with a suitable emulsifier, and if necessary, a colorant, an absorption promoting substance, a protective agent, an antioxidant, a light-shielding agent, a thickening substance, etc. Can be prepared by homogenizing with other phase solvents together with other auxiliary agents.

  As hydrophobic phase (oil), paraffin oil, silicone oil, sesame oil, almond oil, castor oil, synthetic triglyceride, ethyl stearate, di-n-butyryl adipate, hexyl laurate, dipropylene glycol pelargonate, branched chain Of a short fatty acid having a chain length and a saturated fatty acid having a chain length of C16 to C18, isopropyl myristate, isopropyl palmitate, capryl / caprate of a saturated fatty alcohol having a chain length of C12 to C18, isopropyl stearate, oleyl oleate Decyl oleate, ethyl oleate, ethyl lactate, waxy fatty acid ester, dibutyl phthalate, diisopropyl adipate, isotridecyl alcohol, 2-octyldodecanol, cetyl stearyl alcohol, oleyl alcohol It is.

  Examples of the hydrophilic phase include water, propylene glycol, glycerin, and sorbitol.

  Emulsifiers include nonionic interfaces such as polyoxyethylated castor oil, polyoxyethylated sorbitan monoolefin acid, sorbitan monostearate, glyceryl monostearate, polyoxyethyl stearate, alkylphenol polyglycol ether, etc. Activators; amphoteric surfactants such as disodium N-lauryl-β-iminodipropionate and lecithin; anions such as sodium lauryl sulfate, fatty alcohol sulfate ether, monoethanolamine salt of mono / dialkyl polyglycol orthophosphate Surfactants; cationic surfactants such as cetyltrimethylammonium chloride.

  Other adjuvants include carboxymethyl cellulose, methyl cellulose, polyacrylate, alginate, gelatin, gum arabic, polyvinyl pyrrolidone, polyvinyl alcohol, methyl vinyl ether, a copolymer of maleic anhydride, polyethylene glycol, wax, colloidal silica.

  Semi-solid preparations can be administered by application on the skin or spreading or introduction into body cavities. Gels can be prepared by adding sufficient thickener to a solution prepared as described above for an injectable solution to produce a clear material having an ointment-like consistency.

  Next, formulation examples of the preparation when the compound of the present invention is used are shown. However, the formulation examples of the present invention are not limited to these. In the following formulation examples, “parts” means parts by weight.

[Wettable powder]
Compound of the present invention 0.1-80 parts Solid carrier 5-98.9 parts Surfactant 1-10 parts Others 0-5 parts Others include, for example, anti-caking agents and decomposition inhibitors.

[Milk]
Compound of the present invention 0.1 to 30 parts Liquid carrier 45 to 95 parts Surfactant 4.9 to 15 parts Others 0 to 10 parts Others include, for example, spreading agents, decomposition inhibitors and the like.

[Suspension]
Compound of the present invention 0.1 to 70 parts Liquid carrier 15 to 98.89 parts Surfactant 1 to 12 parts Others 0.01 to 30 parts Others include, for example, antifreezing agents and thickeners.

(Granule wettable powder)
Compound of the present invention 0.1 to 90 parts Solid carrier 0 to 98.9 parts Surfactant 1 to 20 parts Others 0 to 10 parts Others include, for example, binders and decomposition inhibitors.

(Liquid)
Compound of the present invention 0.01 to 70 parts Liquid carrier 20 to 99.99 parts Others 0 to 10 parts Other examples include antifreezing agents and spreading agents.

[Granule]
Compound of the present invention 0.01 to 80 parts Solid carrier 10 to 99.99 parts Others 0 to 10 parts Others include, for example, binders, decomposition inhibitors and the like.

[Dust]
Compound of the present invention 0.01 to 30 parts Solid support 65 to 99.99 parts Others 0 to 5 parts Other examples include a drift inhibitor and a decomposition inhibitor.

  Next, although the formulation example which uses this invention compound as an active ingredient is shown more concretely, this invention is not limited to these.

  In the following formulation examples, “parts” means parts by weight.

[Formulation Example 1] Wetting Agent Compound No. 1-005 20 parts Pyrophyllite 74 parts Solpol 5039 4 parts (mixture of nonionic surfactant and anionic surfactant: Toho Chemical Co., Ltd.) Product name)
Carplex # 80D 2 parts (Synthetic hydrous silicic acid: Shionogi & Co., Ltd. trade name)
The above is uniformly mixed and ground to obtain a wettable powder.

[Composition Example 2] Milk Compound of the present invention No.1-005 5 parts Xylene 75 parts N-methylpyrrolidone 15 parts Solpol 2680 5 parts (mixture of nonionic surfactant and anionic surfactant: Toho Chemical Industry (Product name)
The above is uniformly mixed to obtain an emulsion.

[Formulation Example 3] Suspension Agent Compound No. 1-005 25 parts Agrisol S-710 10 parts (nonionic surfactant: trade name of Kao Corporation)
LUNOX 1000C 0.5 part (anionic surfactant: Toho Chemical Industries, Ltd. trade name)
Xanthan gum 0.2 parts water 64.3 parts After uniformly mixing the above, wet pulverize to make a suspension.

[Composition Example 4] Granule wettable powder Compound No. 1-005 of the present invention 75 parts Hytenol NE-15 5 parts (anionic surfactant: trade name of Daiichi Kogyo Seiyaku Co., Ltd.)
Vanillex N 10 parts (anionic surfactant: Nippon Paper Industries Co., Ltd. trade name)
Carplex # 80D 10 parts (Synthetic hydrous silicic acid: Shionogi & Co., Ltd. trade name)
After uniformly mixing and pulverizing the above, a small amount of water is added, stirred and mixed, granulated with an extrusion granulator, and dried to obtain a granulated wettable powder.

[Formulation Example 5] Granules Invention compound No. 1-005 5 parts Bentonite 50 parts Talc 45 parts After uniformly mixing and pulverizing the above, a small amount of water is added and mixed with stirring, and granulated with an extrusion granulator. And dried into granules.

[Formulation Example 6] Powder Compound of the present invention No.1-005 3 parts Carplex # 80D 0.5 part (Synthetic hydrous silicic acid: Shionogi Pharmaceutical Co., Ltd. trade name)
Kaolinite 95 parts Diisopropyl phosphate 1.5 parts The above is uniformly mixed and ground to obtain a powder.

  In use, the above preparation is diluted 1 to 10000 times with water or sprayed directly without dilution.

[Formulation Example 7] wettable powder preparation Compound No. 1-005 of the present invention 25 parts sodium diisobutylnaphthalenesulfonate 1 part calcium n-dodecylbenzenesulfonate 10 parts alkylaryl polyglycol ether 12 parts naphthalenesulfonic acid formalin condensate Sodium salt 3 parts Emulsion type silicone 1 part Silicon dioxide 3 parts Kaolin 45 parts [Formulation Example 8] Water-soluble thickener preparation Compound No.1-005 20 parts Polyoxyethylene lauryl ether 3 parts Sodium dioctyl sulfosuccinate 3. 5 parts dimethyl sulfoxide 37 parts 2-propanol 36.5 parts [Formulation Example 9] Liquid formulation for spraying the present compound No.1-005 2 parts dimethyl sulfoxide 10 parts 2-propanol 35 parts acetone 53 parts [Formulation Example 10] transdermal Solution for administration The present compound No.1-005 5 Part hexylene glycol 50 parts Isopropanol 45 parts [Formulation Example 11] Solution for transdermal administration Compound No. 1-005 5 parts Propylene glycol monomethyl ether 50 parts Dipropylene glycol 45 parts [Formulation example 12] Transdermal administration (instillation) ) Solution for Invention Invention Compound No.1-005 2 parts Light Liquid Paraffin 98 parts [Formulation Example 13] Solution for Percutaneous Administration (Drip) Compound for Invention Compound No.1-005 2 parts Light Liquid Paraffin 58 parts Olive Oil 30 parts ODO -H 9 parts Shin-Etsu Silicone 1 part In addition, when the compound of the present invention is used as an agrochemical, other types of herbicides, various insecticides, acaricides, nematicides, You may mix and apply with a disinfectant, a plant growth regulator, a synergist, a fertilizer, a soil conditioner, etc.

  In particular, when mixed with other pesticides or plant hormones, the cost can be reduced by reducing the amount of applied medicine, the insecticidal spectrum can be expanded by the synergistic action of the mixed drugs, and higher pest control effects can be expected. At this time, a combination with a plurality of known agricultural chemicals is also possible. Examples of the type of agricultural chemical used in combination with the compound of the present invention include compounds described in the 2005 Crop Protection Handbook (Crop Protection Handbook). Specific examples of common names are as follows, but the general names are not necessarily limited to these.

  Bactericides: acibenzolar-S-methyl, acylaminobenzamide, acypetacs, aldimorph, amisulbrom, amobam, ampropyfos, Anilazine, azaconazole, azithiram, azoxystrobin, barium polysulfide, benalaxyl, benodanil, benomyl, benquinox , Benthaluron, benthiavalicarb, benthiazole, benzamacril, benzamorf, bethoxazine, binapacryl, biphenyl, bitertanol ,blast Idin-S (blasticidin-S), Bordeaux mixture, boscalid, bromoconazole, bupirimate, buthiobate, calcium polysulfide, captafol , Captan, carpropamid, carbamorph, carbendazim, carboxin, carvone, carvone, cheshunt mixture, chinomethionat, clobenazone (Chlobenthiazone), chloraniformethane, chloranil, chlorfenazol, chloroneb, chloropicrin, chlorothalonil, chlorquinox, clozolinate linate), climbazole, clotrimazole, copper acetate, basic carbonate, copper carbonate, copper hydroxide, copper naphthenate , Copper oleate, copper oxychloride, copper sulfate, copper sulfate, basic, copper zinc chromate, cufraneb, Cuprobam, cyazofamid, cyclafuramid, cycloheximide, cyflufenamid, cymoxanil, cypendazole, cyproconazol, din , Cyprofuram, dazomet, debacarb, decafenci Decafentin, dehydroacetic acid, dichlofluanid, dichlone, dichlorophen, dichlorophenoline, diclobutrazol, diclocymet, diclocymet, Diclomedine, dicloran, diethofencarb, difenoconazole, diflumetorim, dimethirimol, dimethomorph, dimethomorph, dimoxystrobin, dimoxystrobin M (diniconazole-M), dinobuton, dinocap, dinocap-4, dinocap-6, dinoton, dinosulfon, dinoterbon , Diphenylamine mine, dipyrithione, ditalimfos, dithianon, dodemorph, dodine, drazoxolone, edifenphos, epoxiconazole, etaconazole, eta Etem, ethirimol, ethoxyquin, etridiazole, famoxadone, fenarimol, febuconazole, fenamidone, fenaminosulf, fenilil ), Fendazosulam, fenfuram, fenhexamid, fenitropan, fenoxanil, fenpiclonil, fenpropidin, fenproidin Morph (fenpropimorph), fentin, ferbam, ferimzone, fluazinam, fludioxonil, flumetover, flumorph, flumorph, fluoroimide, fluotrimazole ( fluotrimazole), fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, folpet, fosetyl-aluminum ( fosetyl-aluminium, fuberidazole, fluralaxyl, furametpyr, furcarbanil, furcarbanil, furconazole, fluconazole-cis, furmecyclox, furmecyclox, fumeidyl Furphanate, glyodin, griseofulvin, guazatine, halacrinate, hexachlorobenzene, hexaconazole, hexylthiofos, hydroxyquinoline sulphate 8-hydroxyquinoline sulfate, hymexazol, imazalil, imibenconazole, iminoctadine, ipconazole, iprobenfos, iprodione, iprodione, iprodione isoprothiolane), isovaledione, kasugamycin, kresoxim-methyl, mancopper, mancozeb, maneb, mebe Mebenil, mecarbinzid, mepanipyrim, mepronil, metalaxyl, metalaxyl-M, metam, metazoxolon, metconazole, metconazole Sulfocarb (methasulfocarb), metfuroxam (methfuroxam), methyl isothiocyanate (methyl isothiocyanate), metiram (metiram), mettominostrobin (metominostrobin), metrafenone (metrafenone), metsulfofax (metsulfovax), milneb (milneb), microbutanil (milneb) (Myclobutanil), microzoline, nabam, natamycin, nickel bis (dimethyldithiocarbamate), nitrostyrene, nitrotar-isopropyl hal-isopropyl, nuarimol, OCH, octhilinone, ofurace, orysastrobin, oxadixyl, oxine copper, oxycarboxin , Oxpoconazole fumarate, pefurzoate, penconazole, pencycuron, penthiopyrad, ortho-phenylphenol, phosdiphen, phthalide ), Picoxystrobin, piperalin, polycarbamate, polyoxins, polyoxorim, potassium azide, potassium hydrogen carbonate, pro Naquinide, probenazole, prochloraz, procymidone, propamocarb hydrochloride, propiconcarb, propineazole, propineb, prothiocarb, prothioconazole ), Pyracarbolid, pyraclostrobin, pyrazophos, pyridinitril, pyrifenox, pyrimethanil, pyroquilon, pyroxycyclyl, poxylpy , Quinomethionate, quinoxyfen, quintozene, quinacetol-sulfate, quinazamid, quinconazole , Rabenzazole, sodium azide, sodium hydrogen carbonate, sodium hypochlorite, sulfur, spiroxamine, salicylanilide, silthiofam (Silthiofam), simeconazole, tebuconazole, tecnazene, tecoram, tetraconazole, thiabendazole, thiadifluor, thicyofen, thifluzamide thifluzamide, thiochlorfenphim, thiophanate, thiophanate-methyl, thioquinox, thiram, thiadinyl, tioxymid, Tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, triamiphos, triarimol, triazoxide, triazoxide, triazbutil, tributyltin oxide (triazbutil) tributyltin oxide, trichlamide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin Vinclozolin, zarilamide, zinc sulfate, zineb, ziram, zoxamide and shiitake mycelium extract.

  Bactericides: benzalkonium chloride, bithionol, bronopol, cresol, formaldehyde, nitrapyrin, oxolinic acid, oxyterracycline , Streptomycin and tecloftalam.

  Nematicides: aldoxycarb, cadusafos, DDBCP, dichlofenthion, DSP (DSP), etoprophos, fenamiphos, fensulfothion, fostiazeto (Fosthiazate), fosthietan, imiciafos, isamifos, isazofos, oxamyl and thionazin.

  Acaricide: acequinocyl, acrinathrin, amitraz, BCI-033 (test name), bifenazate, bromopropylate, chinomethionat, chlorobezilate , Clofentezine, cyenopyrafen, cyflumetofen, cyhexatine, dicofol, dienochlor, denochlor (DNOC), etoxazole, quinazaquin (fenaza) Fenbutatin oxide, fenothiocarb, fenpropathrin, fenpyroximate, fluacrypyrim, halfenprox (halfenpro) x), hexythiazox, milbemectin, propargite, pyridaben, pyrimidifen, S-1870 (test name), spirodiclofen, spiromesifen ( spyromesifen) and tebufenpyrad.

  Insecticides: abamectin, acephate, acetamipirid, alanycarb, aldicarb, allethrin, azinphos-methyl, bacillus thuringiensis ), Bendiocarb, benfuracarb, bensultap, bifenthrin, buprofezin, butocarboxim, carbaryl, carbofuran, carbosulfan , Cartap, chlorfenapyr, chlorfenvinphos, chlorfluazuron, chlorpyrifos, chlorpyrifos-methyl, chromafu Nozide (chromafenozide), clothianidin, cycloprothrin, cyflumetofen, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin Cypermethrin, cyromazine, deltamethrin, diacloden, diafenthiuron, diazinon, dichlorvos, diflubenzuron, dimethylvinphos , Dinotefuran, diofenolan, disulfoton, dimethoate, emamectin-benzoate, EPN, esfenvalerate (Esfenvalerate), etiofencarb, ethiprole, etofenprox, etrimfos, fenitrothion, fenobucarb, fenoxycarb, fenpropathrin, fenpropathrin (Fenthion), fenvalerate, fipronil, flonicamid, flubendiamide, flucythrinate, flufenerim, flufenoxuron, flufenprox ), Fulvalinate, tau-fluvalinate, fonophos, formetanate, formothion, furathiocarb, Halofenozide, hexaflumuron, hydramethylnon, imidacloprid, isofenphos, indoxacarb, isoprocarb, isoxathion, lepimectin (leme) , Lufenuron, malathion, metalaldehyde, metamidophos, methidathion, methacrifos, metaflumizone, metalcarb, methomyl, rene , Methoxychlor, methoxyfenozide, methyl bromide, monocrotophos, muscalure, nitenpyra m), NNI-0101 (test name), omethoate, oxamyl, oxydemeton-methyl, oxydeprofos, parathion, parathion-methyl , Pentachlorophenol (PCP), permethrin, phenthoate, phoxim, phorate, phosalone, phosmet, phosphamidon, pirimicarb , Pirimiphos-methyl, profenfos, prothiofos, propaphos, protrifenbute, pymetrozine, pyraclofos, pyridalyl, pyriproxy Fen (pyriprox yfen), rotenone, rynaxypyr, SI-0405 (study name), sulprofos, silafluofen, spinosad, sulfopep, SYJ-159 (study name), tebufenozide (Tebfenozide), teflubenzuron, tefluthorin, terbufos, tetrachlorovinphos, thiacloprid, thiocyclam, thiodicarb, thiamethoxam, thiamethoxam (Thiofanox), thiometon, tolfenpyrad, tralomethrin, trichlorfon, triazuron, triflumuron, and vamidothion.

  Hereinafter, the present invention will be described in more detail by specifically describing synthesis examples and test examples of the compounds of the present invention as examples, but the present invention is not limited thereto.

[Synthesis example]
Synthesis example 1
5- (3,5-dichlorophenyl) -3- [4- (1,2,4-triazol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole (Compound No. 1 of the present invention) 1-005).

Step 1: Preparation of 3,5-dichloro-1- (1-trifluoromethylethenyl) benzene To a solution of 25.0 g of 3,5-dichlorophenylboric acid in 200 ml of tetrahydrofuran and 100 ml of water, 2-bromo-3,3, 27.5 g of 3-trifluoropropene, 38.0 g of potassium carbonate and 1.84 g of dichlorobis (triphenylphosphine) palladium (II) were added, and the mixture was stirred for 3 hours while heating under reflux. After completion of the reaction, the mixture was allowed to cool to room temperature, 500 ml of ice water was added, and the mixture was extracted with ethyl acetate (500 ml × 1). The organic layer was washed with water, dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography eluting with hexane to obtain 25.7 g of the desired product as a colorless oil. It was.
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.41 (t, J = 2.0Hz, 1H), 7.3-7.35 (m, 2H), 6.05 (q, J = 3.2Hz, 1H), 5.82 ( q, J = 3.2Hz, 1H).

Step 2: Preparation of 5- (3,5-dichlorophenyl) -3- (4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 3.7 g of 4-fluorophenylaldoxime N, N -To 20 ml of dimethylformamide solution, 4.0 g of N-chlorosuccinimide was added and stirred at 70 ° C for 1 hour. The reaction mixture was then cooled to 0 ° C., 3.2 g of 3,5-dichloro-1- (1-trifluoromethylethenyl) benzene and 2.7 g of triethylamine were added, and stirring was continued for another 30 minutes at room temperature. After completion of the reaction, the reaction mixture was poured into 100 ml of ice water, extracted with ethyl acetate (150 ml × 2), the organic layer was washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was removed under reduced pressure. . The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1:10) to obtain 5.1 g of the objective product as white crystals.
Melting point 93.0-95.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.6-7.7 (m, 2H), 7.51 (s, 2H), 7.4-7.45 (m, 1H), 7.1-7.15 (m, 2H), 4.07 (d, J = 17.2Hz, 1H), 3.68 (d, J = 17.2Hz, 1H).

Step 3; Preparation of 5- (3,5-dichlorophenyl) -3- [4- (1,2,4-triazol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole 1 0.07 g of 60% oily sodium hydride was added to 30 ml of N, N-dimethylformamide in 0.11 g of 2,2,4-triazole with stirring under ice cooling, and the mixture was stirred at room temperature for 30 minutes. After the evolution of hydrogen gas ceased, 0.30 g of 5- (3,5-dichlorophenyl) -3- (4-fluorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole was added under ice-cooling and stirring. The mixture was added and stirring was continued at 120 ° C. for 16 hours. After completion of the reaction, the reaction mixture was poured into 30 ml of water, extracted with ethyl acetate (60 ml × 1), the organic layer was washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. . The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 1) to obtain 0.12 g of the desired product as pale yellow crystals.
Melting point: 179.0-181.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ8.64 (s, 1H), 8.14 (s, 1H), 7.75-7.85 (m, 4H), 7.52 (bs, 2H), 7.44 (t, J = 1.8Hz, 1H), 4.12 (d, J = 17.4Hz, 1H), 3.76 (d, J = 17.4Hz, 1H).

Synthesis example 2
3- [4- (5-Bromo-1,2,4-triazol-1-yl) phenyl] -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole Invention compound No. 1-008).

5- (3,5-dichlorophenyl) -3- [4- (1,2,4-triazol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole in a nitrogen atmosphere To a solution of 30 g of 1,2-dichloroethane in 20 ml, 0.42 g of N-bromosuccinimide and 0.01 g of azobisisobutyronitrile were added and stirred for 2 hours while heating under reflux. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, poured into 30 ml of water and extracted with ethyl acetate (50 ml × 1). did. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 2) to obtain 0.05 g of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ8.06 (bs, 1H), 7.8-7.9 (m, 4H), 7.53 (bs, 2H), 7.45 (t, J = 1.8Hz, 1H), 4.13 (d, J = 17.2Hz, 1H), 3.75 (d, J = 17.2Hz, 1H).

Synthesis example 3
5- (3,5-dichlorophenyl) -3- [4- (3-methanesulfonyl-1,2,4-triazol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole ( Compound No.1-007 of the present invention.

5- (3,5-dichlorophenyl) -3- [4- (3-methylthio-1,2,4-triazol-1-yl) phenyl] -5-trifluoromethyl-4 prepared in the same manner as in Synthesis Example 1. To a solution of 0.09 g of 1,5-dihydroisoxazole (present compound No.1-006) in 10 ml of dichloromethane was added 0.30 g of 3-chloroperbenzoic acid, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was poured into 20 ml of water and extracted with ethyl acetate (50 ml × 2). The organic layer was washed with 20 ml of an aqueous sodium hydrogen sulfite solution and then with 20 ml of an aqueous sodium hydrogen carbonate solution. And dehydration and drying, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 1) to obtain 0.09 g of the desired product as a colorless resinous substance.
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ8.77 (s, 1H), 7.8-7.9 (m, 4H), 7.52 (bs, 2H), 7.44 (t, J = 2.0Hz, 1H), 4.14 (d, J = 17.4Hz, 1H), 3.76 (d, J = 17.4Hz, 1H), 3.66 (s, 3H).

Synthesis example 4
1- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] -N- (2,2,2-trifluoroethyl) Pyrazole-4-carboxamide (the present compound No. 1-104).

1- [4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] pyrazole-4-carboxylic acid prepared in the same manner as in Synthesis Example 1. A solution of 0.19 g of ethyl (the present compound No. 1-013) in 10 ml of ethanol was added with 5 ml of water in 0.20 g of potassium hydroxide with stirring at room temperature. Continued. After completion of the reaction, 20 ml of 5N hydrochloric acid aqueous solution was added to the reaction mixture under ice-cooling and the mixture was extracted with ethyl acetate (70 ml × 1). The solvent was distilled off. The residue was dissolved in 10 ml of chloroform, 0.10 g of 2,2,2-trifluoroethylamine, 0.40 g of triethylamine, 0.01 g of 4- (N, N-dimethylamino) pyridine and 1- [3- (diethylamino) Propyl] -3-ethylcarbodiimide hydrochloride (0.20 g) was added, and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was poured into 30 ml of ethyl acetate, the insoluble material was filtered off, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 1) to obtain 0.06 g of the desired product as white crystals.
Melting point 219.0-222.0 ° C
¹ H NMR (CDCl ₃ -DMSO-d ₆ , Me ₄ Si, 400 MHz) δ8.78 (s, 1H), 8.49 (t, J = 6.4Hz, 1H), 8.25 (s, 1H), 7.8-7.85 ( m, 4H), 7.54 (bs, 2H), 4.17 (d, J = 17.4Hz, 1H), 4.0-4.05 (m, 2H), 3.84 (d, J = 17.4Hz, 1H).

Synthesis example 5
5- (3,5-dichlorophenyl) -3- [4- (pyrrol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole (the present compound No. 1-001).

Step 1: Preparation of 3- (4-aminophenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole Reduced iron in 70.0 g water and 30.0 g acetic acid To 8.5 g under stirring at 75 ° C., 5- (3,5-dichlorophenyl) -3- (4-nitrophenyl) -5-trifluoromethyl produced in the same manner as in Step 1 to Step 2 of Synthesis Example 1 A solution of -4,5-dihydroisoxazole (12.4 g) in ethyl acetate (30 ml) was added dropwise, and after completion of the addition, stirring was continued for another 3 hours at the same temperature. After completion of the reaction, insoluble matters were filtered off, and the filtrate was allowed to cool to room temperature and extracted with ethyl acetate (150 ml × 2). The organic layer was washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was subjected to silica gel column chromatography eluting with ethyl acetate-hexane (3: 2). And 8.8 g of the desired product was obtained as reddish brown crystals.
Melting point 98.0-99.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 300MHz) δ7.35-7.55 (m, 5H), 6.65-6.7 (m, 2H), 3.95-4.1 (m, 3H), 3.64 (d, J = 17.4Hz , 1H).

Step 2: Preparation of 5- (3,5-dichlorophenyl) -3- [4- (pyrrol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole 3- (4-aminophenyl) ) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole 0.15 g of 2,5-dimethoxytetrahydrofuran was added to a solution of 0.50 g of acetic acid at 80 ° C. Stir for 2 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, poured into 30 ml of water and extracted with ethyl acetate (50 ml × 1). The organic layer was washed with water, dehydrated and dried in the order of saturated brine and then anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was subjected to silica gel column chromatography eluting with ethyl acetate-hexane (1: 2). To obtain 0.09 g of the desired product as white crystals.
Melting point: 206.0-209.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.7-7.75 (m, 2H), 7.53 (bs, 1H), 7.4-7.5 (m, 2H), 7.25-7.3 (m, 2H), 7.1 -7.15 (m, 2H), 6.35-6.4 (m, 2H), 4.11 (d, J = 17.4Hz, 1H), 3.72 (d, J = 17.4Hz, 1H).

Synthesis Example 6
5- (3,5-dichlorophenyl) -3- [4- (1,3,4-triazol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole (Compound No. 1 of the present invention) 1-010).

3- (4-Aminophenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole prepared in Step 1 of Synthesis Example 5 0.50 g and 1,2- To a solution of 0.35 g of diformylhydrazine in 5 ml of pyridine, 0.92 g of triethylamine and 2.17 g of chlorotrimethylsilane were added dropwise at room temperature with stirring. After completion of the dropwise addition, the temperature was raised to 100 ° C. and stirring was continued for 7 hours. After completion of the reaction, the solvent was distilled off under reduced pressure, 50 ml of water was added to the residue, extracted with ethyl acetate (50 ml × 2), the organic layer was washed with water, dehydrated and dried in the order of saturated saline and then anhydrous sodium sulfate. The solvent was distilled off under. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 1) to obtain 0.29 g of the desired product as white crystals.
Melting point: 250.0-252.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ8.64 (s, 2H), 7.85-7.9 (m, 2H), 7.35-7.6 (m, 5H), 4.16 (d, J = 17.2Hz, 1H ), 3.81 (d, J = 17.2 Hz, 1H).

Synthesis example 7
5- (3,5-dichlorophenyl) -3- [4- (tetrazol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole (the present compound No. 1-011).

To a 4 ml acetic acid solution of 0.50 g of 3- (4-aminophenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole prepared in Step 1 of Synthesis Example 5 0.4 ml of triethyl orthoformate and 0.13 g of sodium azide were added and stirred at 80 ° C. for 5 hours. After completion of the reaction, the reaction mixture was ice-cooled, 30 ml of water was added, and the mixture was extracted with ethyl acetate (50 ml × 1). The organic layer was washed with water, dehydrated and dried in the order of saturated brine and anhydrous sodium sulfate, and the solvent was removed under reduced pressure. Distilled off. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 1) to obtain 0.06 g of the desired product as white crystals.
Melting point 202.0-203.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ9.89 (s, 1H), 7.9-8.05 (m, 4H), 7.57 (bs, 2H), 7.48 (t, J = 1.8Hz, 1H), 4.25 (d, J = 17.4Hz, 1H), 4.01 (d, J = 17.4Hz, 1H).

Synthesis example 8
5- (3,5-dichlorophenyl) -3- [4- (5-methyltetrazol-1-yl) phenyl] -5-trifluoromethyl-4,5-dihydroisoxazole (Compound No. 1-012 of the present invention) ).

To a solution of 0.50 g of 3- (4-aminophenyl) -5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazole prepared in Step 1 of Synthesis Example 5 in 4 ml of acetic acid 0.4 ml of triethyl orthoacetate and 0.13 g of sodium azide were added and stirred at 80 ° C. for 4 hours. After completion of the reaction, the reaction mixture was ice-cooled, 30 ml of water was added, and the mixture was extracted with ethyl acetate (50 ml × 1). The organic layer was washed with water, dehydrated and dried in the order of saturated brine and anhydrous sodium sulfate, and the solvent was removed under reduced pressure. Distilled off. The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (1: 1) to obtain 0.25 g of the desired product as yellow crystals.
Melting point: 132.0-133.0 ° C
¹ H NMR (CDCl ₃ , Me ₄ Si, 400 MHz) δ7.85-7.95 (m, 2H), 7.55-7.65 (m, 2H), 7.53 (bs, 2H), 7.45 (t, J = 1.8Hz, 1H ), 4.14 (d, J = 17.4Hz, 1H), 3.76 (d, J = 17.4Hz, 1H), 2.67 (s, 3H).

  This invention compound can be manufactured according to the said manufacturing method and an Example. Although the example of this invention compound manufactured similarly to the synthesis example 1-the synthesis example 8 is shown in Table 5-Table 7, respectively, this invention is not limited only to these.

Incidentally, heterocyclic ring represented by in the table G ² -1~G ² -8 represent the structures respectively represented by the following,

The numbers representing the substitution positions of the substituents (X) _m , (Y) _n and (Z ^a ) _{p in} the table correspond to the positions of the numbers described in the above and the following structural formulas, respectively. Yes, the-notation represents no substitution.

Furthermore, * 1 in the table means “resinous”.
Table 5

―――――――――――――――――――――――――――――――――――――――
No. (X) _m (Y) _n G ² (Z ^a ) _p mp (℃)
―――――――――――――――――――――――――――――――――――――――
1-001 3,5-Cl ₂ − G ² −1 − 206.0-209.0
1-002 3,5-Cl ₂ − G ² −2 − 171.0-172.0
1-003 3,5-Cl ₂ − G ² -3 − 193.0-195.0
^{_{1-004 3,5-Cl 2 - G 2}} -4 - 176.0-179.0
1-005 3,5-Cl ₂ − G ² -5 − 179.0-181.0
1-006 3,5-Cl ₂ − G ² -5 3-SCH ₃ 130.0-133.0
1-007 3,5-Cl ₂ − G ² -5 3-SO ₂ CH ₃ * 1
1-008 3,5-Cl ₂ − G ² -5 5-Br * 1
1-009 3,5-Cl ₂ 2-CH ₃ G ² -5 − 145.0-146.0
1-010 3,5-Cl ₂ − G ² -7 − 250.0-252.0
1-011 3,5-Cl ₂ − G ² -8 − 202.0-203.0
1-012 3,5-Cl ₂ − G ² -8 CH ₃ 132.0-133.0
1-013 3,5-Cl ₂ − G ² -2 4-C (O) OEt 94.0-96.0
^{_{1-014 3,5-Cl 2 - G 2}} -2 4-C (O) NHCH 2 CF 3 219.0-222.0
―――――――――――――――――――――――――――――――――――――――
Table 6

―――――――――――――――――――――――――――――――――――――――
No. (X) _m (Y) _n G ² (Z ^a ) _p mp (℃)
―――――――――――――――――――――――――――――――――――――――
2-001 3,5-Cl ₂ − G ² -3 − 178.0-180.0
2-002 3,5-Cl ₂ − G ² -5 − 170.0-172.0
―――――――――――――――――――――――――――――――――――――――
Table 7

―――――――――――――――――――――――――――――――――――――――
No. (Y) _n G ² (Z ^a ) _p J mp (℃)
―――――――――――――――――――――――――――――――――――――――
3-001 − G ² -5 − H 211.0-212.0
―――――――――――――――――――――――――――――――――――――――
[Test example]
Next, the usefulness of the compound of the present invention as a pest control agent will be specifically described in the following test examples, but the present invention is not limited to these.

Test Example 1 Insecticidal test against a diamondback moth A 10% emulsion of the compound of the present invention (for some compounds, 25% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Immerse kanran leaves in this solution for about 10 seconds, air-dry and place in a petri dish. 10 second-instar larvae of Plutella xylostella are released per petri dish and covered with a hole. Housed in a constant temperature room. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. The test was conducted in a two-ward system.

As a result, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-001,1-002,1-003,1-004 ^* , 1-005 ^* , 1-006,1-007,1-008,1-009 ^* , 1-010,1 -011 ^* , 1-012 ^* , 1-013,1-014 ^* , 2-001,2-002 ^* .

In addition, the above-mentioned ^* indicates that an insecticidal test was conducted using a chemical solution with a concentration of 100 ppm.

Test Example 2 Insecticidal test against Spodoptera litura 10% emulsion of the compound of the present invention (depending on the compound, 25% wettable powder was tested) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Immerse kanran leaves in this chemical for about 10 seconds, air-dry and place in a petri dish, release 10 second-instar larvae of Spodoptera litura per petri dish, cover with a hole and open 25 Housed in a constant temperature room. The number of dead insects after 6 days was investigated, and the dead insect rate was calculated from the following formula. The test was conducted in a two-ward system.

Death rate (%) = (Number of dead insects / Number of dead insects) × 100
As a result, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-003,1-004 ^* , 1-005 ^* , 1-008,1-009 ^* , 1-010,1-011 ^* , 1-012 ^* , 1-014 ^* , 2- 001,2-002 ^* .

In addition, the above-mentioned ^* indicates that an insecticidal test was conducted using a chemical solution with a concentration of 100 ppm.

Test Example 3 Insecticidal test against Syringoptera: A 10% emulsion of the compound of the present invention (depending on the compound, a 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this solution for about 10 seconds, air-dry and place in a petri dish. In this, 5 second-instar larvae of Spodoptera exigua are released per petri dish, capped and placed in a thermostatic chamber at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the tested compounds, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-009,2-002.

Test Example 4 Insecticidal Test for Chahamaki A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder was tested) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this solution for about 10 seconds, air dry and place in a petri dish. In this, 5 second-instar larvae of Homona magnanima are released per petri dish, covered and placed in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the tested compounds, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-009,2-002.

Test Example 5 Insecticidal test against giant tobacco moth 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder was tested) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 100 ppm. Immerse kanran leaves in this chemical for about 10 seconds, air-dry and place in a petri dish. Release 2 second-instar larvae of Helicoverpa armigera per petri dish, cover and place in a thermostatic chamber at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. Note that the test was conducted in a 12-unit system.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No.1-004, 1-011,1-014.

Test Example 6 Insecticidal test against citrus white thrips Place a wet filter paper on a 7 cm inner diameter styrol cup, place a bean leaf cut to the same diameter on it, and place 1 instar larvae of citrus thrips (Frankliniella occidentalis) per leaf Ten animals were inoculated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No.1-003,1-004,1-005,1-009,1-010,1-011,1-012,1-013,1-014,2-001,2-002.

Test Example 7 Insecticidal test against southern blue thrips Place a wet filter paper on a 7 cm inner diameter styrol cup, place green beans cut to the same diameter on it, and place 10 adult thrips palmi per leaf Vaccinated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 100 ppm, and the chemical solution was prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-009,1-011,1-012,1-013,1-014,2-002.

Test Example 8 Insecticidal test against white-spotted beetle A 10% emulsion of the present compound (10% wettable powder depending on the compound) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. . Immerse rice leaf sheath in this solution for about 10 seconds, air-dry it, put it in a test tube, and release 5 first-instar larvae of Eysarcoris lewisi per test tube, and cover the lid with a sponge. And housed in a constant temperature room at 25 ° C. The number of dead insects after 2 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-009,1-010,1-014,2-001,2-002.

Test Example 9 Insecticidal test against green planthopper A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Immerse rice leaf sheaths in this solution for about 10 seconds, air-dry them, put them in a test tube, and release 5 second-instar larvae of Nilaparvata lugens per test tube, cover them with a sponge, and cover with 25 sponges. Housed in a constant temperature room. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-009,1-010,1-014.

Test Example 10 Insecticidal test for silver leaf whitefly A tomato leaf (10 eggs / leaf) laid on a silver leaf whitefly (Bemisia argentifolii) was cut and placed on a 7 cm inner diameter styrol cup. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
The compound of the present invention: No. 1-005, 1-009, 1-011.

Test Example 11 Insecticidal test against peach aphid A moist absorbent cotton is laid on a glass petri dish with an inner diameter of 3 cm, and kanran leaves cut out to the same diameter are placed on it. did. One day later, a 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm. The chemical solution was sprayed (2.5 mg / cm ² ), covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-002,1-005,1-009.

Test Example 12 Insecticidal test against Aphididae A moist filter paper is placed on a 7 cm inner diameter styrol cup, and a green bean leaf cut out to the same diameter is placed on it, and the 1st instar larvae of Planococcus kraunhiae are placed per leaf. Ten animals were inoculated. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-003,1-005,1-009,1-011,2-001,2-002.

Test Example 13 Insecticidal test against cucumber potato beetle A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. Soak cucumber leaves in this chemical for about 10 seconds, air-dry and place in a petri dish. In this, 5 second-instar larvae of Aulacophora femoralis are released per petri dish, capped and placed in a constant temperature room at 25 ° C. Accommodated. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
Compound of the present invention: No.1-002,1-003,1-004,1-005,1-006,1-009,1-010,1-011,1-012,1-013,1-014, 2-001,2-002.

Test Example 14 Insecticidal test against legume leaf fly A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) was diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm. In this chemical solution, a 7 cm diameter kidney bean leaf (10 eggs / leaf) spawned by Liriomyza trifolii was immersed for about 10 seconds, air-dried, and then wetted filter paper laid on a 7 cm inner diameter styrol cup. It was placed on top, covered and housed in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the dead insect rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-009.

Test Example 15 Insecticidal test against a spider mite A moist filter paper was laid on a styrene cup having an inner diameter of 7 cm, leaves of kidney beans cut to the same diameter were placed thereon, and 10 larvae of the spider mite (Tetranychus urticae) were inoculated per leaf. A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 500 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the compounds tested, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-009,1-010,1-011,1-012,2-002.

Test Example 16 Insecticidal test against citrus mite mites Put a damp filter paper on a 7 cm inner diameter styrol cup, place citrus leaves cut out on the same diameter, and inoculate 10 larvae of citrus mite (Aculops pelekassi) per leaf . A 10% emulsion of the compound of the present invention (depending on the compound, 10% wettable powder) is diluted with water containing a spreading agent to prepare a chemical solution with a concentration of 100 ppm, and the chemical solution is prepared using a rotary spray tower. Each 2.5 ml of styrene cup was sprayed, covered, and stored in a constant temperature room at 25 ° C. The number of dead insects after 6 days was investigated, and the death rate was calculated from the same calculation formula as in Test Example 1. In addition, the test was performed by 2 continuous systems.

As a result, among the tested compounds, the following compounds showed a death rate of 80% or more.
This invention compound: No.1-005,1-009,2-002.

The substituted isoxazoline compound according to the present invention exhibits excellent pest control activity, particularly insecticidal / miticidal activity, and is extremely useful with little adverse effect on non-target organisms such as mammals, fish and beneficial insects. A compound.

Claims (9)

General formula (1):

[Wherein, A ¹ , A ² and A ³ each independently represents a carbon atom or a nitrogen atom,
G ¹ represents a benzene ring, a nitrogen-containing 6-membered aromatic heterocycle, a furan ring, a thiophene ring or a 5-membered aromatic heterocycle containing two or more heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom,
G ² represents a nitrogen-containing 5-membered aromatic heterocycle bonded with a nitrogen atom,
X is a halogen atom, nitro, azido, -SCN, -SF _5, cyano, C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁴ (C ₃ ~C ₈₎ cycloalkyl, E1～E18, optionally substituted by C ₂ -C _{6 ^{alkenyl, R 4 (C 2 ~C 6}} ) alkenyl, C ₃ ~ C ₈ cycloalkenyl, C ₃ -C ₈ halocycloalkyl cycloalkenyl, C ₂ -C ₆ alkynyl, optionally substituted by R ⁴ (C ₂ ~C _{6) ^{alkynyl, -OH, -OR 5, -OSO 2}} R 5 , -SH, -S (O) _r R ⁵ , -NH ₂ , -N (R ⁷ ) R ⁶ , -N = CHOR ⁸ , -N = C (R ⁹ ) OR ⁸ , -CHO, -C (O ) R ⁹ , -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ ,- C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -CH = NOR ¹¹ , -C (R ⁹ ) = NOR ¹¹ , M3, M11, M17, -S (O) ₂ OR ⁹ , -S (O) ₂ NH ₂ , -S (O) ₂ N (R ¹⁰ ) R ⁹ , -Si (R ^12a ) (R ^12b ) R ¹² , phenyl, (Z) Feni substituted by _p1 Or D1 to D38, and when m represents an integer of 2 or more, each X may be the same as or different from each other,
Further, when two Xs are adjacent to each other, the two adjacent Xs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ N (R ¹³ )-, -CH ₂ N (R ¹³ ) CH _2- , -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -CH ₂ CH = CH-,- OCH = CH-, -SCH = CH-, -N (R ¹³ ) CH = CH-, -OCH = N-, -SCH = N-, -N (R ¹³ ) CH = N-, -N (R ¹³ By forming N = CH-, -CH = CHCH = CH-, -OCH ₂ CH = CH-, -N = CHCH = CH-, -N = CHCH = N- or -N = CHN = CH- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each of two Xs is bonded. At this time, the hydrogen atom bonded to each carbon atom forming the ring is optionally substituted by Z. In addition, when simultaneously substituted with two or more Z, each Z may be the same as or different from each other,
Y is a halogen atom, nitro, azido, -SCN, -SF _5, cyano, C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl , optionally substituted by R ⁴ (C ₃ ~C ₈₎ cycloalkyl, E1~E18, C ₂ ~C ₆ alkinyl, optionally substituted by R ⁴ (C ₂ ~C ₆₎ alkynyl, -OH, -OR ⁵ , -OSO ₂ R ⁵ , -SH, -S (O) _r R ⁵ , -NH ₂ , -N (R ⁷ ) R ⁶ , -N (R ⁷ ) C (O) R ^9a , -N (R ⁷ ) C (O) OR ^9a , -N (R ⁷ ) C (O) SR ^9a , -N (R ⁷ ) C (S) OR ^9a , -N (R ⁷ ) C (S) SR ^9a , -N (R ⁷ ) S (O) ₂ R ^9a , -N = CHOR ⁸ , -N = C (R ⁹ ) OR ⁸ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R _{^{9, -C (S) NH 2}} , -C (S) N (R 10) R 9, -Si (R 12a) (R 12b) R 12, phenyl, phenyl or D1~ substituted by (Z) _p1 When Y represents an integer of 2 or more, each Y may be the same as or different from each other;
Further, when two Ys are adjacent to each other, the two adjacent Ys are —CH ₂ CH ₂ CH ₂ —, —CH ₂ CH ₂ O—, —CH ₂ OCH ₂ —, —OCH ₂ O—, —CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -SCH ₂ S-, -CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH ₂ -,- By forming CH ₂ OCH ₂ O-, -OCH ₂ CH ₂ O-, -OCH ₂ CH ₂ S-, -SCH ₂ CH ₂ S-, -OCH = N- or -SCH = N- A 5-membered ring or a 6-membered ring may be formed together with the carbon atom to which each Y is bonded, and at this time, the hydrogen atom bonded to each carbon atom forming the ring may be optionally substituted by Z Furthermore, when two or more Z are substituted at the same time, each Z may be the same as or different from each other,
Z ^a is a halogen atom, cyano, nitro, optionally substituted by C ₁ -C _{6 ^{alkyl, R 4 (C 1 ~C 6}} ) ^{alkyl, -OH, -OR 5, -OS (} O) 2 R 5 , -SH, -S (O) _r R ⁵ , -NH ₂ , -N (R ⁷ ) R ⁶ , -CHO, -C (O) R ⁹ , -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) N (R ² ) R ¹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) N (R ² ) R ¹ , -CH = NOR ¹¹ , -C (R ⁹ ) = NOR ¹¹ , M3, M11, M17, -S (O) ₂ NH ₂ , -S (O) ₂ N (R ¹⁰ ) R ⁹ , phenyl or (Z) _p1 phenyl, when p represents an integer of 2 or more, each Z ^a may be the even or different from each other the same as each other,
Further, two Z ^a is when the adjacent two Z ^a adjacent, may form a fused ring by forming a -CH = CH-CH = CH-, this time, to form a ring each hydrogen halogen atoms bonded to carbon atoms, cyano group, nitro group, C ₁ -C ₄ alkyl group, C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio groups Optionally substituted by
R ¹ is hydrogen atom, cyano, optionally substituted by C ₁ -C ₁₂ alkyl, optionally substituted by R ¹⁴ (C ₁ ~C ₁₂₎ alkyl, C ₃ -C ₁₂ cycloalkyl, R ¹⁴ ( C ₃ -C ₁₂₎ cycloalkyl, E2~E5, E8, E11~E14, E17 , C 3 ~C 12 alkenyl, optionally substituted by R ¹⁴ (C ₃ ~C ₁₂₎ alkenyl, C ₃ -C ₁₂ cycloalkenyl, C ₃ -C ₁₂ halo cycloalkenyl, C ₃ -C ₁₂ alkynyl, optionally substituted by R ¹⁴ (C ₃ ~C ₁₂₎ alkynyl, -CHO, -C (O) R 15, -C ( R ¹⁶ ) = NOR ¹⁵ , -C (O) OR ¹⁵ , -C (O) SR ¹⁵ , -C (O) NH ₂ , -C (O) N (R ¹⁶ ) R ¹⁵ , -C (O) NHC (O) R ¹⁵ , -C (O) N (R ¹⁶ ) C (O) OR ¹⁵ , -C (S) OR ¹⁵ , -C (S) SR ¹⁵ , -C (S) NH ₂ , -C ( S) N (R ¹⁶ ) R ¹⁵ , M7, M9, M13, M15, -OR ¹⁷ , -N (R ¹⁸ ) R ¹⁷ , -N = C (R ^17b ) R ^17a , -SR ¹⁵ , -S (O ) ₂ R ¹⁵ , -SN (R ²⁰ ) R ¹⁹ , -S (O) ₂ N (R ¹⁶ ) R ¹⁵ , phenyl, phenyl substituted by (Z) _p1 , D1-D25 or D27-D38 And
R ² is a hydrogen atom, cyano, C ₁ -C ₁₂ alkyl, (C ₁ -C ₁₂ ) alkyl, C ₃ -C ₁₂ cycloalkyl, C ₃ -C ₁₂ alkenyl, C ₃ optionally substituted by R ^14a -C ₁₂ haloalkenyl, C ₃ -C ₁₂ cycloalkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, -CHO, -C (O) R 15a, -C (O) OR 15a, -C (O) SR ^15a , -C (O) NH ₂ , -C (O) N (R ^16a ) R ^15a , -C (O) NHC (O) R ^15a , -C (S) OR ^15a , -C ( S) SR ^15a , -C (S) NH ₂ , -C (S) N (R ^16a ) R ^15a , -OR ¹⁷ , -N (R ¹⁸ ) R ¹⁷ , -N = C (R ^17b ) R ^17a , -SR ¹⁵ , -S (O) ₂ R ^15a , -SN (R ²⁰ ) R ¹⁹ , -S (O) ₂ N (R ^16a ) R ^15a , phenyl or phenyl substituted by (Z) _p1 or by R ² is either form together with ^{R 1 = C (R 2a)} R 1a, or R ² forms a C ₂ -C ₇ alkylene chain together with R ^1, It represents that a 3-8 membered ring may be formed together with the nitrogen atom to be bonded. Is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, C ₁ -C ₆ alkoxy (C ₁ -C ₆₎ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ haloalkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, C ₁ -C ₆ haloalkoxycarbonyl group , C ₁ -C ₆ alkylaminocarbonyl group, C ₁ -C ₆ halo alkylaminocarbonyl group, a phenyl group, a phenyl group substituted by (Z) _p1, D32 group, optionally substituted with D34 group, oxo group or thioxo group May have been
R ^1a and R ^2a are each independently a hydrogen atom, C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₃ -C ₁₂ cycloalkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ haloalkenyl. , C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ ^{haloalkynyl, -OR 15, -SR 15, -NH} 2, -NHOH, -N (R 16) R 15, substituted by phenyl or (Z) _p1 Represents phenyl, or R ^1a and R ^2a together form a C ₄ -C ₅ alkylene chain or a C ₄ -C ₅ alkenylene chain to form a 5- to 6-membered ring with the carbon atoms to which it is attached. indicates that may be formed, this time the alkylene chain or alkenylene chain oxygen atom, may contain one to three sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ ~ C ₆ haloalkyl group, C ₁ -C ₆ alkoxy group, C ₁ -C ₆ haloalkoxy group, C ₁ -C ₆ alkylthio group, C ₁ -C ₆ Haroa Kiruchio group or may be optionally substituted by R ^17b group,
R ³ represents a halogen atom, cyano, optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ⁴ ( C ₃ -C ₈₎ cycloalkyl, substituted E1~E18, C ₃ ~C ₆ alkenyl, optionally substituted by R ⁴ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₆ alkynyl, optionally by R ⁴ been (C ₂ ~C ₆₎ ^{alkynyl, -OR 5, -S (O)} r R 5, -N (R 10) R 9, -N (R 10) R 9a, -CHO, -C (O) R ⁹ , -C (O) OR ⁹ , -C (O) SR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C (S) N (R ¹⁰ ) R ⁹ , -CH = NOR ¹¹ , -C (R ⁹ ) = NOR ¹¹ , -Si (R ^12a ) ( ^{R 12b) R 12, -P (} O) (oR 21) 2, represent phenyl, phenyl or D1~D38 substituted by (Z) _p1,
D1 to D38 each represent an aromatic heterocycle represented by the following structural formula;

Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~ C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, -OH, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ haloalkyl sulfonyloxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ Haroaruki Sulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -NH _2, C ₁ ~C ₆ alkyl amino, di (C ₁ -C ₆ alkyl) amino, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C _{6 haloalkoxycarbonyl, -C (O) NH 2,} C 1 ~C 6 alkyl amino carbonyl, C ₁ -C ₆ haloalkylcarbonyl aminocarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, -C (S _{) NH 2, -S (O)} 2 NH 2, C 1 ~C 6 alkylaminosulfonyl, di (C ₁ -C ₆ alkyl) aminosulfonyl, phenyl optionally substituted by phenyl or halogen atom, p1, when p2, p3 or p4 represents an integer of 2 or more, each Z may be the same as or different from each other;
Further, when two Zs are adjacent to each other, the two adjacent Zs are -CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ O-, -CH ₂ OCH _2- , -OCH ₂ O-, -CH ₂ CH ₂ S-, -CH ₂ SCH _2- , -CH ₂ CH ₂ CH ₂ CH ₂ CH _2- , -CH ₂ CH ₂ CH ₂ O-, -CH ₂ CH ₂ OCH _2- , -CH ₂ OCH ₂ O- , -OCH ₂ CH ₂ O-, -CH ₂ CH ₂ CH ₂ S-, -OCH ₂ CH ₂ S- or -CH = CH-CH = CH- may form a 5- or 6-membered ring together with the carbon atom, this time, the hydrogen atoms bonded to each carbon atom forming the ring is a halogen atom, a cyano group, a nitro group, C ₁ -C ₄ alkyl group may be optionally substituted by C ₁ -C ₄ haloalkyl groups, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio group,
E1 to E18 each represent a saturated heterocyclic ring represented by the following structural formula;

R ⁴ is a halogen atom, cyano, C _{3 to} C ₈ cycloalkyl, C _{3 to} C ₈ halocycloalkyl, E1 to E18, —OH, —OR ⁵ , —SH, —S (O) _r R ⁵ , — N (R ⁷ ) R ⁶ , -N (R ⁷ ) C (O) R ^9a , -N (R ⁷ ) C (O) OR ^9a , -N (R ⁷ ) C (O) SR ^9a , -N ( R ⁷ ) C (S) OR ^9a , -N (R ⁷ ) C (S) SR ^9a , -N (R ⁷ ) S (O) ₂ R ^9a , -C (O) OR ⁹ , -C (O) N (R ¹⁰ ) R ⁹ , -Si (R ^12a ) (R ^12b ) R ¹² , phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ⁵ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ²⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ²⁴ (C ₃ ~C ₈ ) cycloalkyl, E2~E5, E11~E13, E14, E17 , C 2 ~C 6 alkenyl, optionally substituted by R ²⁴ (C ₂ ~C ₆₎ alkenyl, C ₃ -C ₈ cycloalkenyl, C ₃ -C ₈ halocycloalkyl cycloalkenyl, C ₃ -C ₆ alkynyl, optionally substituted by R ²⁴ (C ₃ ~C ₆₎ alkynyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, ( Z) represents phenyl, D1, D2, D4-D6, D8-D10, D12-D19, D21, D23, D25, D27, D30-D37 or D38 substituted by _p1 ,
R ⁶ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, -C (O) R 9, -C (O) OR 9, -C (O) SR ⁹ , -C (O) NH ₂ , -C (O) N (R ¹⁰ ) R ⁹ , -C (S) OR ⁹ , -C (S) SR ⁹ , -C (S) NH ₂ , -C ( S) N (R ¹⁰ ) R ⁹ , -C (O) C (O) R ⁹ , -C (O) C (O) OR ⁹ , -OH, -S (O) ₂ R ⁹ , -S (O ) ₂ N (R ¹⁰ ) R ⁹ , -P (O) (OR ²¹ ) ₂ or -P (S) (OR ²¹ ) ₂
R ⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, C ₁ -C ₆ alkylcarbonyl, or represents C ₁ -C ₆ haloalkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl, or , R ⁷ together with R ⁶ to form a C ₂ -C ₆ alkylene chain, it is possible to form a 3- to 7-membered ring with the nitrogen atom to which R ⁷ is bonded, oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, may be optionally substituted by oxo or thioxo group,
R ⁸ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ alkenyl, phenyl or phenyl substituted by (Z) _p1 ;
R ⁹ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ²⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1-E18, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl or C ₂ -C ₆ haloalkynyl,
R ^9a represents phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ¹⁰ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, or represents C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or, R ¹⁰ is R by forming a C ₂ -C ₆ alkylene chain together with ^9, it indicates that may form a 3- to 7-membered ring together with the nitrogen atom to which they are attached this case the alkylene chain an oxygen atom, a sulfur atom or nitrogen atoms may be one comprise, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl Optionally substituted by a group,
R ¹¹ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ represents alkenyl, C ₃ -C ₆ haloalkenyl, a C ₃ -C ₆ alkynyl or C ₃ -C ₆ haloalkynyl,
R ¹² represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _p1 ;
R ^12a and R ^12b each independently represent C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₆ alkoxy;
R ¹³ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxycarbonyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxycarbonyl (C ₁ -C ₄₎ alkyl, phenyl (C ₁ -C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ -C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ ~ C ₆ represents alkynyl, C ₃ -C ₆ haloalkynyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenyl substituted by phenyl or (Z) _p1,
Further, when Z is present at the adjacent position to R ¹³ is, -CH ₂ and adjacent R ¹³ and _{Z CH 2 CH 2 CH 2 -} , -CH = CH-CH = CH-, -N = CH- By forming CH = CH-, -CH = N-CH = CH-, -CH = CH-N = CH- or -CH = CH-CH = N-, a 6-membered ring is formed together with the atoms to which each is bonded. it may be formed, this time, the hydrogen atoms bonded to each carbon atom forming the ring may be optionally substituted by halogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl group ,
R ¹⁴ is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, hydroxy (C ₃ -C ₆ ) cycloalkyl, C ₁ -C ₄ alkoxy (C ₃ -C ₆₎ cycloalkyl, C ₅ -C ₆ ^{cycloalkenyl, E1~E18, -OR 25, -N (} R 26) R 25, -SH, -S (O) r R 27, -CHO, -C (O) R ²⁸ , -C (R ³¹ ) = NOH, -C (R ³¹ ) = NOR ³⁰ , M3, M4, M11, M12, -C (O) OH, -C (O) OR ²⁸ , -C (O) SR ²⁸ , -C (O) NH ₂ , -C (O) N (R ²⁹ ) R ²⁸ , -C (O) N (R ²⁹ ) OR ²⁸ , -C (O) N (R ²⁹ ) N (R ^28a ) R ²⁸ , -C (S) OR ²⁸ , -C (S) SR ²⁸ , -C (S) NH ₂ , -C (S) N (R ²⁹ ) R ²⁸ , -C (= NR ³¹ ) OR ³⁰ , -C (= NR ³¹ ) SR ³⁰ , -C (= NR ³¹ ) N (R ²⁹ ) R ³⁰ , -C (= NOR ³¹ ) NH ₂ , -C (= NOR ³¹ ) N (R ²⁹ ) R ^{30, M1, M2, M5~M10,} M13~M18, -C (O) C (O) OR 28, -SO 2 OH, -SO 2 NH 2, -SO 2 N (R 29) R 28, -Si (R ^12a ) (R ^12b ) R ¹² , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, phenyl substituted by (Z) _p1, naphthoquinone It represents Le or D1～D38,
M1 to M18 each represents a partially saturated heterocyclic ring represented by the following structural formula,

R ^14a is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, C ₅ -C ₆ cycloalkenyl, -OR ²⁵ , -N (R ²⁶ ) R ²⁵ , -S (O) _r R ²⁷ ,- CHO, -C (O) R ²⁸ , -C (R ³¹ ) = NOH, -C (R ³¹ ) = NOR ³⁰ , -C (O) OH, -C (O) OR ²⁸ , -C (O) SR _{^{28, -C (O) NH 2}} , -C (O) N (R 29) R 28, -C (S) OR 28, -C (S) SR 28, -C (S) NH 2, -C ( S) N (R ²⁹ ) R ²⁸ , -C (O) C (O) OR ²⁸ , -C (= NR ³¹ ) OR ³⁰ , -C (= NR ³¹ ) SR ³⁰ , -C (= NR ³¹ ) N (R ²⁹ ) R ³⁰ , -C (= NOR ³¹ ) NH ₂ , -C (= NOR ³¹ ) N (R ²⁹ ) R ³⁰ , M1, M3, M5, M5, M9, M11, M13, M15, M17, -SO ₂ OH, -SO ₂ NH ₂ , -SO ₂ N (R ²⁹ ) R ²⁸ , -Si (R ^12a ) (R ^12b ) R ¹² , -P (O) (OR ²¹ ) ₂ , -P (S ) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, (Z) _p1 substituted with phenyl, naphthyl or D1-D38,
R ¹⁵ is C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1-E18, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl, represents phenyl, phenyl or D1~D38 substituted by (Z) _p1,
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfinyl (C _{1 ~C 4)} alkyl, C ₁ -C ₄ alkylsulfonyl (C _{1 ~C 4)} alkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C _{8 halocycloalkyl, E3~E5, E11~E13, C 2 ~C} 6 alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl represents C ₁ -C ₆ alkoxycarbonyl, phenyl, phenyl or D1~D38 substituted by (Z) _p1,
R ¹⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, cyano (C ₁ ~C ₆₎ alkyl, or represents C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl, or, R ¹⁶ is R ^{by 15} together to form a C ₂ -C ₆ alkylene chain, represents that may form a 3- to 7-membered ring together with the atoms connecting, this time the alkylene chain an oxygen atom, a sulfur atom or nitrogen atoms may be one comprise, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl group Optionally substituted by
R ^16a represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹⁷ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ¹⁴ , C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E 3- E5, E11~E13, C ₃ ~C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, -CHO, -C (O) R 28, -C ( O) OR ²⁸ , -C (O) SR ²⁸ , -C (O) NH ₂ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) OR ²⁸ , -C (S) SR ²⁸ , _{-C (S) NH 2, -C} (S) N (R 29) R 28, -S (O) 2 R 28, -S (O) 2 NH 2, -S (O) 2 N (R 29) R ²⁸ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, phenyl substituted by (Z) _p1 , D1-D6, D8-D12, D14-D19, D23 , D25, D30 to D37 or D38,
R ^17a is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl , C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ ~C ₄₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, substituted by (Z) _p1 phenyl (C ₁ -C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, E1～E18, phenyl (C ₂ -C ₄₎ alkenyl, di (C ₁ -C ₆ alkyl) amino, phenyl, (Z) _p1 Represents phenyl or D1-D38 substituted by
R ^17b represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio or di (C ₁ -C ₆ alkyl) amino, or R ^17a and R ^17b Together form a C ₃ -C ₅ alkylene chain to form a 4-6 membered ring with the carbon atoms to which it is bonded, wherein the alkylene chain is an oxygen atom, sulfur atom or one nitrogen atom may contain, and halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or a C ₁ -C ₆ alkoxycarbonyl group Optionally substituted by
R ¹⁸ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ haloalkylsulfonyl (C _{1 ~C 4)} alkyl, cyano (C _{1 ~C 6)} alkyl, C ₁ -C ₄ alkoxycarbonyl (C _{1 ~C 4)} alkyl, phenyl (C _{1 ~C 4)} alkyl , (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ alkynyl, C ₃ -C ₆ haloalkynyl, - ^{CHO, -C (O) R 15} , -C (O) oR 15, -C (O) SR 15, -C (S) oR 15, -C (S) SR 15, C 1 ~C 6 alkylsulfonyl or or represents C ₁ -C ₆ haloalkylsulfonyl, or together with R ¹⁸ is R ¹⁷ By now it forms a C ₄ -C ₅ alkylene chain, represents that may form a 5- or 6-membered ring together with the nitrogen atom to which they are attached this case the alkylene chain an oxygen atom, a sulfur atom or a nitrogen atom 1 to C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy (C ₁ -C ₆ ) alkyl group, -CHO group, C ₁ -C ₆ alkylcarbonyl group or C ₁ -C ₆ alkoxy Optionally substituted by a carbonyl group,
R ¹⁹ is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, C ₁ -C ₁₂ alkylcarbonyl, C ₁ -C ₁₂ alkoxycarbonyl, -C (O) ON = C (CH 3) SCH 3, -C (O) ON = C (SCH ₃ ) C (O) N (CH ₃ ) ₂ represents phenyl or phenyl substituted by (Z) _p1 ,
R ²⁰ is C ₁ -C ₁₂ alkyl, C ₁ -C ₁₂ haloalkyl, C ₁ -C ₁₂ alkoxy (C ₁ -C ₁₂ ) alkyl, cyano (C ₁ -C ₁₂ ) alkyl, C ₁ -C ₁₂ alkoxycarbonyl (C ₁ ~C ₁₂₎ alkyl, phenyl (C ₁ ~C ₄₎ alkyl, (Z) phenyl substituted by _p1 (C ₁ ~C ₄₎ alkyl, C ₃ -C ₁₂ alkenyl, C ₃ -C ₁₂ halo alkenyl, C ₃ -C ₁₂ alkynyl, C ₃ -C ₁₂ haloalkynyl, phenyl or (Z) or represents phenyl which is substituted by _p1, or, R ²⁰ together with R ¹⁹ C ₄ ~C ₇ alkylene By forming a chain, it represents that a 5- to 8-membered ring may be formed together with the nitrogen atom to be bonded, and at this time, the alkylene chain may contain one oxygen atom or sulfur atom, and C ₁ -C may be optionally substituted by ₄ alkyl or C ₁ -C ₄ alkoxy group,
R ²¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ²² is a halogen atom, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ -C ₆ ) alkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkoxycarbonyl (C ₁ -C ₄₎ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylamino, di (C ₁ -C ₄ alkyl) amino, C ₁ ~ C ₆ alkoxycarbonyl, represents phenyl substituted by phenyl or _{(Z) p1, q1, q2} , q3, q4, when q5 or q6 is an integer of 2 or more, each R ²² is also the same as each other , or may be the different from each other, further, when two R ²² are substituted on the same carbon atom, the two R ²² oxo together, thioxo, imino, C ₁ -C ₆ alkyl indicates that the imino, may form a C ₁ -C ₆ alkoxyimino or C ₁ -C ₆ alkylidene,
R ²³ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C optionally substituted by R ³² ₆ haloalkenyl, C ₃ -C ₆ alkynyl, -OH, benzyloxy, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR ³⁴ , -C (O) N (R ³⁴ ) R ³³ , -C (S) NHR ³⁴ , -C (S) N (R ³⁴ ) R ³³ , -S (O) ₂ R ³³ , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , phenyl, (Z) represents phenyl substituted by _p1 or D3,
R ²⁴ is halogen atom, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E1~E18, C ₁ ~C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, C ₁ -C ₆ alkylamino, di (C ₁ -C ₆ alkyl) amino, -CHO, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, C ₁ -C ₆ alkylaminocarbonyl, di (C ₁ -C ₆ alkyl) amino Represents carbonyl, phenyl, phenyl substituted by (Z) _p1 or D1-D38;
R ²⁵ is a hydrogen atom, C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, optionally substituted by R ³² (C ₃ -C ₈₎ cycloalkyl, E2~E5, E11~E14, E17, C 3 ~C 8 alkenyl, optionally substituted by R ³² (C ₃ ~C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, R ³² optionally substituted by (C ₃ ~C ₈₎ alkynyl, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR 34, -C (O) N (R ³⁴ ) R ³³ , -C (S) R ³³ , -C (S) OR ³³ , -C (S) SR ³³ , -C (S) NHR ³⁴ , -C (S) N (R ³⁴ ) R ³³ , -C (O) C (O) R ³³ , -C (O) C (O) OR ³³ , -S (O) ₂ R ³³ , -S (O) ₂ N (R ^{34) R 33, -Si (R} 12a) (R 12b) R 12, -P (O) (OR 21) 2, -P (S) (OR 21) 2, phenyl, substituted by (Z) _p1 Phenyl, D1, D2, D4 to D6, D8 to D10, D12 to D19, D21, D23, D25, D27, D30 to D37 or D38,
R ²⁶ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkoxy, phenyl or phenyl substituted by (Z) _{p 1} or R ²⁶ is By forming a C ₂ -C ₅ alkylene chain together with R ²⁵ , this means that a 3- to 6-membered ring may be formed together with the nitrogen atom to be bonded, and this alkylene chain is an oxygen atom, sulfur atom or a nitrogen atom may be one comprise a, and halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl group, C ₁ -C ₆ alkoxy group, a phenyl group, substituted by (Z) _p1 Optionally substituted by a phenyl, oxo or thioxo group,
R ²⁷ is optionally substituted by C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ ~C ₈₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³² (C ₃ ~C ₈ ) cycloalkyl, E2~E5, E11~E14, E17, C 3 ~C 8 alkenyl, optionally substituted by R ³² (C ₃ -C ₈₎ alkenyl, C ₃ -C ₈ alkynyl, optionally by R ³² substituted (C ₃ ~C ₈₎ alkynyl, -CHO, -C (O) R 33, -C (O) OR 33, -C (O) SR 33, -C (O) NHR 34, -C ( O) N (R ³⁴ ) R ³³ , -C (S) R ³³ , -C (S) OR ³³ , -C (S) SR ³³ , -C (S) NHR ³⁴ , -C (S) N (R ^{34) R 33, -C (O} ) C (O) R 33, -C (O) C (O) OR 33, -SH, C 1 ~C 6 alkylthio, C ₁ -C ₆ haloalkylthio, phenylthio, ( phenylthio substituted by _{Z) p1, -P (O)} (OR 21) 2, -P (S) (OR 21) 2, phenyl, phenyl substituted by _{(Z) p1, D9, D10} , D12, D14 ~ Represents D17, D32 or D34,
R ²⁸ is optionally substituted by C ₁ -C ₆ alkyl, optionally substituted by R ³² (C ₁ ~C ₆₎ alkyl, C ₃ -C ₈ cycloalkyl, R ³² (C ₃ ~C ₈ ) cycloalkyl, C ₂ -C ₆ alkenyl (C ₃ -C ₈₎ cycloalkyl, C ₂ -C ₆ haloalkenyl (C ₃ -C ₈₎ cycloalkyl, E1~E18, C ₂ ~C ₈ alkenyl, R ³² substituted phenyl which optionally substituted (C ₂ ~C ₈₎ alkenyl, C ₂ -C ₈ alkynyl, optionally substituted by R ³² (C ₂ ~C ₈₎ alkynyl, phenyl, by (Z) _p1 by Or D1-D38,
R ^28a represents a hydrogen atom or a C ₁ -C ₆ alkyl,
R ²⁹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ³² , C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C Represents ₆ alkynyl, C ₃ -C ₆ haloalkynyl, phenyl or phenyl substituted by (Z) _{p 1} , or R ²⁹ together with R ²⁸ forms a C ₂ -C ₅ alkylene chain Represents that a 3- to 6-membered ring may be formed together with the nitrogen atom to be bonded, in which case the alkylene chain may contain one oxygen atom, sulfur atom or nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkylcarbonyl group, C ₁ -C ₆ alkoxycarbonyl group, optionally by phenyl substituted by phenyl or (Z) _p1 May be replaced,
R ³⁰ is C ₁ -C ₈ alkyl, optionally substituted by R ³² (C ₁ -C ₈ ) alkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ alkenyl, optionally substituted by R ³² and (C ₃ ~C ₈₎ alkenyl, optionally substituted by C ₃ -C ₈ alkynyl, or R ³² (C ₃ ~C ₈₎ alkynyl,
R ³¹ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₆ haloalkoxy (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ haloalkylthio (C ₁ ~C ₄₎ alkyl, C ₁ -C ₆ alkylsulfonyl (C _{1 ~C 4)} alkyl, C ₁ -C ₆ haloalkylsulfonyl (C _{1 ~C 4)} alkyl, phenyl (C _{1 ~C 4)} alkyl, phenyl substituted by (Z) _p1 (C ₁ ~C ₄₎ represents alkyl, C ₃ -C ₆ cycloalkyl, phenyl substituted by phenyl or (Z) _p1,
R ³² is a halogen atom, nitro, cyano, C ₃ -C ₈ cycloalkyl, C ₃ -C ₈ halocycloalkyl, E3, E4, E6, E7 , E9, E11, E12, E14, E15, E17, -OH , -OR ³³ , -OC (O) R ³³ , -OC (O) OR ³³ , -OC (O) NHR ³⁴ , -OC (O) N (R ³⁴ ) R ³³ , -OC (S) NHR ³⁴ , -OC (S) N (R ³⁴ ) R ³³ , -SH, -S (O) _r R ³³ , -SC (O) R ³³ , -SC (O) OR ³³ , -SC (O) NHR ³⁴ ,- SC (O) N (R ³⁴ ) R ³³ , -SC (S) NHR ³⁴ , -SC (S) N (R ³⁴ ) R ³³ , -NHR ³⁴ , -N (R ³⁴ ) R ³³ , -N (R ³⁴ ) CHO, -N (R ³⁴ ) C (O) R ³³ , -N (R ³⁴ ) C (O) OR ³³ , -N (R ³⁴ ) C (O) NHR ³⁴ , -N (R ³⁴ ) C (O) N (R ³⁴ ) R ³³ , -N (R ³⁴ ) C (S) NHR ³⁴ , -N (R ³⁴ ) C (S) N (R ³⁴ ) R ³³ , -CHO, -C (O) R ³³ , -C (O) OH, -C (O) OR ³³ , -C (O) SR ³³ , -C (O) NHR ³⁴ , -C (O) N (R ³⁴ ) R ³³ , -C ( O) C (O) OR ³³ , -Si (R ^12a ) (R ^12b ) R ¹² , -P (O) (OR ²¹ ) ₂ , -P (S) (OR ²¹ ) ₂ , -P (phenyl) ₂ , -P (O) (phenyl) ₂ , phenyl, phenyl substituted by (Z) _p1 or D1-D38,
R ³³ is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³⁵ , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocyclo. alkyl, C ₂ -C ₆ alkenyl (C ₃ ~C ₈₎ cycloalkyl, C ₂ -C ₆ haloalkenyl (C ₃ ~C ₈₎ cycloalkyl, E3, E4, E11, E12 , C 2 ~C 8 alkenyl, C ₂ -C ₈ haloalkenyl, C ₃ -C ₈ cycloalkenyl, C ₃ -C ₈ halocycloalkyl cycloalkenyl, C ₂ -C ₈ alkynyl, C ₂ -C ₈ haloalkynyl, substituted phenyl, the (Z) _p1 Represents phenyl or D1-D38,
R ³⁴ is a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ alkynyl, C ₁ -C ₆ alkylcarbonyl , C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ haloalkoxycarbonyl, phenoxycarbonyl, phenoxycarbonyl substituted by (Z) _p1, phenylcarbonyl, substituted by (Z) _p1 phenylcarbonyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, phenyl, phenyl substituted by _{(Z) p1, D1, D2} , D4~D6, D8~D10, D12~D19, D21, D21, D23, D25, D27, or represents D30~D37 or D38, or, R ³⁴ is 3-6 by forming a C ₂ -C ₅ alkylene chain together with R ^33, together with the nitrogen atom bonded Represents that a member ring may be formed. It can the alkylene chain is an oxygen atom, may contain one sulfur atom or a nitrogen atom, and a halogen atom, C ₁ -C ₆ alkyl group, C ₁ -C ₆ alkoxy group, -CHO group, C ₁ -C ₆ alkyl carbonyl group, C ₁ -C ₆ alkoxycarbonyl group, it may be optionally substituted by a phenyl group substituted by a phenyl group or (Z) _p1,
R ³⁵ represents cyano, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, E3, E4, E11, E12 , C 1 ~C 4 alkoxy, C ₁ -C ₄ haloalkoxy, phenoxy, (Z ) _p1 phenoxy substituted by, C ₁ -C ₄ alkylthio, C ₁ -C ₄ haloalkylthio, C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ haloalkylsulfonyl, phenylthio, phenylthio substituted by (Z) _p1 , -N (R ³⁷ ) R ³⁶ , C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, di (C ₁ -C ₆ alkyl) aminocarbonyl, tri (C ₁ -C ₄ alkyl) silyl, phenyl, phenyl, naphthyl or D1~D38 substituted by (Z) _p1,
R ³⁶ is phenyl substituted by a hydrogen atom, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkylcarbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, phenylcarbonyl or (Z) _p1 Represents carbonyl,
R ³⁷ represents a hydrogen atom or C ₁ -C ₄ alkyl,
m represents an integer of 0 to 5;
n represents an integer of 0 to 4,
p represents an integer of 0 to 4,
p1 represents an integer of 1 to 5,
p2 represents an integer of 0 to 4,
p3 represents an integer of 0 to 3,
p4 represents an integer of 0 to 2,
p5 represents an integer of 0 or 1,
q1 represents an integer of 0 to 3,
q2 represents an integer of 0 to 5,
q3 represents an integer of 0 to 7,
q4 represents an integer of 0 to 9,
q5 represents an integer of 0 to 6,
q6 represents an integer of 0 to 4,
r represents an integer of 0 to 2;
t represents an integer of 0 or 1. ]
Or a salt thereof. A ¹ represents a carbon atom or a nitrogen atom,
A ² and A ³ represent a carbon atom,
G ¹ represents a benzene ring,
G ² represents a nitrogen-containing aromatic 5-membered ring represented by any of G ² -1 to G ² -9,

X is a halogen atom, nitro, -SF _5, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, hydroxy (C ₁ ~C ₆₎ haloalkyl, C ₁ -C ₆ alkoxy (C ₁ -C ₆ ) Haloalkyl, C ₃ -C ₈ halocycloalkyl, —OR ⁵ , —OSO ₂ R ⁵ or —S (O) _r R ^5, and when m represents 2 or 3, each X is identical to each other. Or they may be different from each other,
Y is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, optionally substituted by C ₁ -C _{6 ^{haloalkyl, R 4 (C 1 ~C 4}} ) alkyl, C ₃ -C ₆ alkynyl, -OR ⁵ , —SR ⁵ , —NH ₂ , —N (R ⁷ ) R ⁶ or —C (S) NH _2, and when n represents ₂ , each Y may be the same as or different from each other You may,
Z ^a is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, optionally substituted by R ⁴ (C ₁ ~C ₆₎ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -C (O) N (R 2) R 1 or ^{-C (S) N (R 2} ) represents R ^1, when p2~p4 represents an integer of 2 or more, each Z ^a are each They may be the same or different from each other,
R ¹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl, C ₃ -C ₆ cycloalkyl, E 3, E 11, C ₃ -C ₆ alkenyl optionally substituted by R ¹⁴ , C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ ^{alkynyl, -C (R 16) = NOR} 15, -C (O) OR 15, -C (O) NH 2, -C (O) N (R 16 ) R ¹⁵ , -C (O) NHC (O) R ¹⁵ , -C (O) N (R ¹⁶ ) C (O) OR ¹⁵ , -C (S) NH ₂ , -C (S) N (R ^{16 ) R 15, -N (R 18} ) R 17, phenyl substituted by _{(Z) p1, D5~D8, D10} , D17, represents D32~D34 or D35,
R ² is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ^14a , C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ alkenyl, C ₃ -C ₆ represents an ^{alkynyl, -C (O) R 15a,} -C a (O) oR ^15a or C ₁ -C ₆ haloalkylthio,
R ³ represents C ₁ -C ₆ haloalkyl or C ₃ -C ₈ halocycloalkyl,
Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfonyloxy, C ₁ -C ₆ represent alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, -C (O) NH _2, a -C (S) NH ₂ or _{-S (O) 2 NH 2,} p1, when p2 and p3 represent an integer of 2 or more, each Z may be the same as or different from each other;
R ⁴ represents —OH, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio,
R ⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or C ₁ -C ₃ haloalkoxy (C ₁ -C ₃ ) haloalkyl,
R ⁶ is, C ₁ -C ₆ alkyl, -CHO, C ₁ ~C ₆ alkyl carbonyl, C ₁ -C ₆ haloalkylcarbonyl, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ alkylthiocarbonyl, C ₁ -C ₆ alkoxythiocarbonyl, C ₁ -C ₆ alkyl dithio carbonyl, represents C ₁ -C ₆ alkylsulfonyl or C ₁ -C ₆ haloalkylsulfonyl,
R ⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹³ represents C ₁ -C ₆ alkyl,
R ¹⁴ is halogen atom, cyano, C ₃ -C ₆ cycloalkyl, E3, E6, -OH, -OR 25, C 1 ~C 6 alkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ alkylsulfonyl , -N (R ²⁶ ) R ²⁵ , C ₁ -C ₆ alkylcarbonyl, -C (R ³¹ ) = NOR ³⁰ , -C (O) N (R ²⁹ ) R ²⁸ , -C (S) NH ₂ , phenyl (Z) represents phenyl substituted by _p1 , D1, D5, D7, D8, D10, D13, D16, D17, D22, D32 or D34,
R ^14a represents a halogen atom, cyano or -OR ²⁵ ,
R ¹⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, (C ₁ -C ₄ ) alkyl optionally substituted by R ³² or C ₂ -C ₆ alkenyl,
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, C ₁ -C ₆ Represents alkoxycarbonyl, phenyl, phenyl substituted by (Z) _p1 or D32;
R ¹⁶ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹⁷ represents C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxycarbonyl, phenyl, phenyl substituted by (Z) _p1 , D32 or D34,
R ¹⁸ represents a hydrogen atom, C ₁ -C ₆ alkyl, C ₃ -C ₆ alkenyl or C ₃ -C ₆ alkynyl,
R ²² represents C ₁ -C ₆ alkyl;
R ²⁵ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, -C (O) R ³³ or -C (O) OR ³³ ,
R ²⁶ represents a hydrogen atom, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl,
R ²⁸ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ²⁹ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ³⁰ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or C ₁ -C ₆ cycloalkyl (C ₁ -C ₄ ) alkyl;
R ³¹ represents a hydrogen atom or C ₁ -C ₄ alkyl,
R ³² represents C ₃ -C ₆ cycloalkyl, C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkoxycarbonyl, phenyl substituted by (Z) _p1 or D32,
R ³³ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₆ cycloalkyl or phenyl;
m represents an integer of 1 to 3,
n represents an integer of 0 or 1,
p1 represents an integer of 1 to 3,
p2 and p3 represent an integer of 0 to 2,
q2 represents an integer of 0 to 3,
q3 and q4 represent an integer of 0 to 2,
The substituted isoxazoline compound or a salt thereof according to claim 1, wherein t represents 0. G ² represents G ² -1, G ² -2, G ² -3, G ² -4, G ² -5, G ² -7 or G ² -8,
X is a halogen atom, nitro, cyano, C ₁ -C ₆ represents alkyl, C ₁ -C ₆ haloalkyl, the -OR ⁵ or -S (O) _{r R} ^5, when m is 2 or 3, each of the X may be the same as or different from each other;
Y is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, -OR ^5, -SR ^5, an -NH ₂ or -N (R ⁷⁾ R ^6,
Z ^a is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ ~ C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -C (O) N (R 2) R 1 or -C (S) N (R ² ) R ¹ and when p represents an integer of 2 or more, each Z ^a may be the same as or different from each other,
R ¹ is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₆ ) alkyl optionally substituted by R ¹⁴ , C ₃ -C ₆ cycloalkyl, E3, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ ^{alkynyl, -C (R 16) = NOR} 15, -C (O) OR 15, -C (O) NH 2, -C (O) N (R 16) R ¹⁵ , -C (O) NHC (O) R ¹⁵ , -C (O) N (R ¹⁶ ) C (O) OR ¹⁵ , -N (R ¹⁸ ) R ¹⁷ , (Z) phenyl substituted by _p1 , D6-D8, D10, D32, D34 or D35,
R ² is a hydrogen atom, C ₁ -C ₆ alkyl, (C ₁ -C ₄ ) alkyl, C ₃ -C ₆ alkynyl, optionally substituted by R ^14a , -C (O) R ^15a , -C (O ) represents oR ^15a or C ₁ -C ₆ haloalkylthio,
R ³ represents C ₁ -C ₆ haloalkyl,
Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, a C ₁ -C ₆ alkoxy or C ₁ -C ₆ alkylsulfonyloxy, p1 indicates an integer of 2 or more Each Z may be the same as or different from each other,
R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ⁶ represents C ₁ -C ₆ alkyl, —CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
R ¹⁴ is halogen atom, cyano, C ₃ -C _{6 cycloalkyl, E3, E6, C 1 ~C} 6 alkoxy, C ₁ -C ₆ ^{haloalkoxy, -NHC (O) OR 33,} -C (R 31) = NOR ³⁰ , -C (O) N (R ²⁹ ) R ²⁸ , phenyl, (Z) represents phenyl, D1, D8, D10, D13, D16, D22, D32 or D34 substituted by _p1 ,
R ^14a represents cyano or -OR ²⁵
R ¹⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or (C ₁ -C ₄ ) alkyl optionally substituted by R ³² ;
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylthio (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ ~C ₄₎ represents alkyl, C ₁ -C ₄ alkylsulfonyl (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ cycloalkyl or C ₂ -C ₆ alkenyl,
R ¹⁷ represents C ₁ -C ₆ haloalkyl, phenyl, phenyl substituted by (Z) _p1 , D32 or D34,
R ²⁵ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or -C (O) R ³³ ;
R ²⁸ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ³⁰ represents C ₁ -C ₄ alkyl,
R ³² represents phenyl substituted by (Z) _p1 ,
R ³³ represents C ₁ -C ₄ alkyl,
p2, p3 and p4 represent an integer of 0 or 1,
q2 represents an integer of 0 or 1,
The substituted isoxazoline compound or a salt thereof according to claim 2, wherein q3 represents 0. A ¹ represents a carbon atom,
G ² represents G ² -2, G ² -5 or G ² -8,
X is a halogen atom or a C ₁ -C ₆ haloalkyl, when m is 2 or 3, each X may be the or different from each other the same as each other,
Y represents a halogen atom, nitro, a C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
Z ^a represents -C (O) N (R ² ) R ¹
R ¹ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ² represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ³ represents -CF ₃ or -CF ₂ Cl,
p3 represents 1,
The substituted isoxazoline compound or a salt thereof according to claim 3, wherein p4 and p5 represent 0. General formula (2):

[Wherein A ¹ represents a carbon atom or a nitrogen atom,
J represents a hydrogen atom or a halogen atom,
G ² is a nitrogen-containing aromatic 5-membered ring G ² -1, G ² -2, G ² -3, G ² -4, G ² -5, G ² -7, or Represents G ² -8,

Y represents a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, the -OR ⁵ or -N (R ⁷⁾ R ^6,
Z ^a is a halogen atom, cyano, nitro, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, -C (O) N (R 2) R 1 or ^{-C (S) N (R 2} ) represents R ^1, when p represents an integer of 2 or more, each Z ^a may be the even or different from each other the same as each other,
R ¹ is hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ¹⁴ (C ₁ ~C ₆₎ alkyl, C ₃ -C ₆ cycloalkyl, E3, C ₃ -C ₆ alkenyl, C ₃ -C ₆ haloalkenyl, C ₃ -C ₆ ^{alkynyl, -C (O) OR 15,} -C (O) NH 2, -C (O) N (R 16) R 15, -C (O) NHC (O ) R ¹⁵ , -C (O) N (R ¹⁶ ) C (O) OR ¹⁵ , (Z) represents phenyl, D6-D8, D10, D32, D34 or D35 substituted by _p1 ,
R ² is a hydrogen atom, C ₁ -C ₆ alkyl, optionally substituted by R ^14a (C ₁ ~C ₄₎ alkyl, C ₃ -C ₆ alkynyl, -C (O) R ^15a or -C (O Represents OR ^15a
R ³ represents C ₁ -C ₆ haloalkyl,
R ⁵ represents C ₁ -C ₆ alkyl or C ₁ -C ₆ haloalkyl,
R ⁶ represents -CHO, C ₁ -C ₆ alkylcarbonyl or C ₁ -C ₆ alkoxycarbonyl,
R ⁷ represents a hydrogen atom or C ₁ -C ₆ alkyl,
R ¹⁴ is halogen atom, cyano, C ₃ -C _{6 cycloalkyl, E3, E6, C 1 ~C} 6 alkoxy, C ₁ -C ₆ ^{haloalkoxy, -NHC (O) OR 33,} -C (O) N (R ²⁹⁾ R ^28, represents phenyl, (Z) phenyl substituted by _{p1, D1, D8, D10,} D13, D16, D22, D32 or D34,
D1, D6 to D8, D10, D13, D16, D22, D32, D34 and D35 each represent an aromatic heterocycle represented by the following structural formula,

Z is a halogen atom, nitro, cyano, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, a C ₁ -C ₆ alkoxy or C ₁ -C ₆ alkylsulfonyloxy, p1 indicates an integer of 2 or more Each Z may be the same as or different from each other,
R ¹³ represents C ₁ -C ₆ alkyl,
E3 and E6 each represent a saturated heterocyclic ring represented by the following structural formula;

R ^14a represents cyano or -OR ²⁵
R ¹⁵ represents C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl or (C ₁ -C ₄ ) alkyl optionally substituted by R ³² ;
R ^15a is C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfinyl (C ₁ -C ₄ ) alkyl, C ₁ -C ₄ alkylsulfonyl (C _{1 ~C 4)} represents alkyl, a C ₃ -C ₆ cycloalkyl or C ₂ -C ₆ alkenyl,
R ²² represents C ₁ -C ₆ alkyl;
R ²⁵ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl or -C (O) R ³³ ;
R ²⁸ represents C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₃ -C ₄ alkenyl or C ₃ -C ₄ alkynyl,
R ³² represents phenyl substituted by (Z) _p1 ,
R ³³ represents C ₁ -C ₄ alkyl,
n represents an integer of 0 or 1,
p1 represents an integer of 1 to 3,
p2, p3, p4 and p5 represent an integer of 0 or 1,
q2 represents an integer of 0 or 1,
q3 represents 0,
t represents 0. ]
A 4-substituted benzaldoxime compound represented by the formula: A pest control agent comprising one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1 as active ingredients. An agrochemical containing one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1 as active ingredients. A mammalian or avian internal or ectoparasite control agent comprising, as an active ingredient, one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1. An insecticide or acaricide containing one or more selected from the substituted isoxazoline compounds and salts thereof according to claim 1 as active ingredients.