JP2006522940A - マイクロチャネルにおけるポリマーの操作 - Google Patents

マイクロチャネルにおけるポリマーの操作 Download PDF

Info

Publication number
JP2006522940A
JP2006522940A JP2006510081A JP2006510081A JP2006522940A JP 2006522940 A JP2006522940 A JP 2006522940A JP 2006510081 A JP2006510081 A JP 2006510081A JP 2006510081 A JP2006510081 A JP 2006510081A JP 2006522940 A JP2006522940 A JP 2006522940A
Authority
JP
Japan
Prior art keywords
polymer
microchannel
flow
fluid
control channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006510081A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006522940A5 (enExample
Inventor
マーティン フックス，
ジョナサン ラルソン，
Original Assignee
ユー．エス． ジェノミクス， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユー．エス． ジェノミクス， インコーポレイテッド filed Critical ユー．エス． ジェノミクス， インコーポレイテッド
Publication of JP2006522940A publication Critical patent/JP2006522940A/ja
Publication of JP2006522940A5 publication Critical patent/JP2006522940A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0463—Hydrodynamic forces, venturi nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1413—Hydrodynamic focussing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
JP2006510081A 2003-04-10 2004-04-08 マイクロチャネルにおけるポリマーの操作 Pending JP2006522940A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46185103P 2003-04-10 2003-04-10
PCT/US2004/011664 WO2004091795A2 (en) 2003-04-10 2004-04-08 Manipulation of polymers in a microchannel

Publications (2)

Publication Number Publication Date
JP2006522940A true JP2006522940A (ja) 2006-10-05
JP2006522940A5 JP2006522940A5 (enExample) 2007-05-31

Family

ID=33299869

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006510081A Pending JP2006522940A (ja) 2003-04-10 2004-04-08 マイクロチャネルにおけるポリマーの操作

Country Status (4)

Country Link
US (1) US20050112606A1 (enExample)
EP (1) EP1620203A2 (enExample)
JP (1) JP2006522940A (enExample)
WO (1) WO2004091795A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020043874A (ja) * 2012-02-10 2020-03-26 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ 検体の解析方法
KR102887643B1 (ko) 2020-01-14 2025-11-19 포스 애널리터컬 에이/에스 유체역학적 포커싱 장치

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7775368B2 (en) * 1995-04-03 2010-08-17 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
ATE273381T1 (de) 1997-02-12 2004-08-15 Eugene Y Chan Verfahren zur analyse von polymeren
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
WO2002044425A2 (en) * 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
WO2003091455A1 (en) * 2002-04-23 2003-11-06 U.S.Genomics, Inc. Compositions and methods related to two-arm nucleic acid probes
US7282330B2 (en) 2002-05-28 2007-10-16 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
EP1546380A4 (en) 2002-05-28 2007-02-14 Us Genomics Inc METHODS AND APPARATUSES FOR ANALYZING SIMPLE POLYMERS
WO2004007692A2 (en) * 2002-07-17 2004-01-22 U.S.Genomics, Inc. Methods and compositions for analyzing polymers using chimeric tags
JP2006520463A (ja) * 2003-01-23 2006-09-07 ユー．エス． ジェノミクス， インコーポレイテッド ポリマー集団を解析するための方法
JP2007501003A (ja) * 2003-08-01 2007-01-25 ユー．エス． ジェノミクス， インコーポレイテッド 非切断条件下で核酸を分析するための配列特異的エンドヌクレアーゼの使用に関連した方法および組成物
US7013739B2 (en) * 2003-08-29 2006-03-21 The Board Of Trustees Of The Leland Stanford Junior University System and method for confining an object to a region of fluid flow having a stagnation point
US7977048B2 (en) 2004-01-13 2011-07-12 Pathogenetix, Inc. Detection and quantification of analytes in solution using polymers
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
US20050196790A1 (en) * 2004-02-05 2005-09-08 U.S. Genomics, Inc. Methods for detection and quantitation of minimum length polymers
EP1737567A1 (en) * 2004-03-02 2007-01-03 Velocys, Inc. Microchannel polymerization reactor
EP1725587A2 (en) * 2004-03-19 2006-11-29 U.S. Genomics, Inc. Compositions and methods for detection of single molecules
WO2006017274A2 (en) * 2004-07-13 2006-02-16 U.S. Genomics, Inc. Systems and methods for sample modification using fluidic chambers
US7351538B2 (en) 2004-08-23 2008-04-01 U.S. Genomics Systems and methods for detecting and analyzing polymers
WO2006098772A2 (en) * 2004-10-13 2006-09-21 U.S. Genomics, Inc. Systems and methods for measurement optimization
WO2006044728A2 (en) * 2004-10-18 2006-04-27 U.S.Genomics, Inc. Methods for isolation of nucleic acids from prokaryotic spores
US20060160231A1 (en) * 2004-11-24 2006-07-20 U.S. Genomics, Inc. Linear analysis of polymers
JP4587215B2 (ja) * 2005-02-16 2010-11-24 セイコーインスツル株式会社 成分分離機構と成分分離方法
US20070128083A1 (en) * 2005-07-18 2007-06-07 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
WO2007011622A2 (en) * 2005-07-18 2007-01-25 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
US20100035247A1 (en) * 2005-11-04 2010-02-11 U.S. Genomics, Inc. Heterogeneous Assay of Analytes in Solution Using Polymers
CN101548172A (zh) * 2006-12-01 2009-09-30 皇家飞利浦电子股份有限公司 流式细胞操纵器
US8999636B2 (en) * 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
JP2010523121A (ja) * 2007-04-05 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー マイクロスケールｔ−接点を用いる生体分子の電気泳動的延伸のためのシステム
US20100294665A1 (en) * 2007-07-12 2010-11-25 Richard Allen Method and system for transferring and/or concentrating a sample
AU2015205826B2 (en) * 2008-06-06 2017-07-27 Bionano Genomics, Inc. Integrated nanofluidic analysis devices, fabrication methods and analysis techniques
KR20110016479A (ko) 2008-06-06 2011-02-17 바이오나노매트릭스, 인크. 통합 나노유체 분석 장치, 제작 방법 및 분석 기술
US8056343B2 (en) * 2008-10-01 2011-11-15 General Electric Company Off center combustor liner
US8361716B2 (en) * 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
EP2570488A1 (en) * 2011-09-16 2013-03-20 Centre National de la Recherche Scientifique (C.N.R.S) Method for longitudinal macromolecule spreading and method for analyzing macromolecules
US8956815B2 (en) 2012-04-18 2015-02-17 Toxic Report Llc Intercalation methods and devices
WO2013158860A1 (en) * 2012-04-18 2013-10-24 Pathogenetix, Inc. Devices and methods for nucleic acid preparation and analysis
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
GB201211557D0 (en) 2012-06-29 2012-08-15 Ibm Microfluidic surface processing device and method
GB2528632A (en) * 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
JP6712999B2 (ja) * 2014-12-16 2020-06-24 セルダイナミクス アイ エス アール エル 流体中の懸濁粒子のリアルタイム分析装置および該粒子の分析方法
CN105675859B (zh) * 2016-01-20 2017-11-07 大连理工大学 一种迷宫式微流体延时流动操控单元
WO2020069609A1 (en) 2018-10-01 2020-04-09 Gervais Thomas System and method of fluid delivery
US20240053244A1 (en) * 2022-08-09 2024-02-15 International Business Machines Corporation Multi-point capacitive motion sensing structure

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503334A (ja) * 1996-09-04 2002-01-29 テクニカル ユニバーシティ オブ デンマーク 粒子の分離と分析用のマイクロフローシステム
JP2002522780A (ja) * 1998-08-13 2002-07-23 ユー．エス．ゲノミクス ポリマーの光学的な特性決定
JP2003507026A (ja) * 1999-08-13 2003-02-25 ユー．エス．ジェノミクス，インコーポレーテッド ポリマーを引き伸ばす方法および装置

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4793705A (en) * 1987-10-07 1988-12-27 The United States Of America As Represented By The United States Department Of Energy Single molecule tracking
US5720928A (en) * 1988-09-15 1998-02-24 New York University Image processing and analysis of individual nucleic acid molecules
US6150089A (en) * 1988-09-15 2000-11-21 New York University Method and characterizing polymer molecules or the like
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
JP3123249B2 (ja) * 1991-09-10 2001-01-09 株式会社日立製作所 Ｄｎａ分子の長さ計測方法および計測装置
WO1994016104A1 (en) * 1993-01-08 1994-07-21 Ctrc Research Foundation Color imaging system for use in molecular biology
CA2155186A1 (en) * 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
US5427663A (en) * 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
FR2737574B1 (fr) * 1995-08-03 1997-10-24 Pasteur Institut Appareillage d'alignement parallele de macromolecules et utilisation
US5707808A (en) * 1996-04-15 1998-01-13 The Regents Of The University Of California Optical selection and collection of DNA fragments
US6120666A (en) * 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
US6403311B1 (en) * 1997-02-12 2002-06-11 Us Genomics Methods of analyzing polymers using ordered label strategies
ATE273381T1 (de) * 1997-02-12 2004-08-15 Eugene Y Chan Verfahren zur analyse von polymeren
EE9900357A (et) * 1997-02-21 2000-02-15 Burstein Laboratories, Inc. Geenisekvenaator ja meetodid
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6263286B1 (en) * 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
US6210896B1 (en) * 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6245507B1 (en) * 1998-08-18 2001-06-12 Orchid Biosciences, Inc. In-line complete hyperspectral fluorescent imaging of nucleic acid molecules
EP1157144A4 (en) * 1999-01-13 2010-04-28 Cornell Res Foundation Inc MANUFACTURE OF FLUIDER MONOLITHIC STRUCTURES
US6193647B1 (en) * 1999-04-08 2001-02-27 The Board Of Trustees Of The University Of Illinois Microfluidic embryo and/or oocyte handling device and method
US6248537B1 (en) * 1999-05-28 2001-06-19 Institut Pasteur Use of the combing process for the identification of DNA origins of replication
US6664104B2 (en) * 1999-06-25 2003-12-16 Cepheid Device incorporating a microfluidic chip for separating analyte from a sample
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6790328B2 (en) * 2000-01-12 2004-09-14 Ut-Battelle, Llc Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
AU2001290879A1 (en) * 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
DE60138824D1 (de) * 2000-10-31 2009-07-09 Caliper Life Sciences Inc Mikrofluidisches verfahren für in-situ-materialkonzentration
AU2002351187A1 (en) * 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
US20050112616A1 (en) * 2001-12-10 2005-05-26 William Lee Functionalized materials and libraries thereof
US7282330B2 (en) * 2002-05-28 2007-10-16 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
US20050042665A1 (en) * 2003-08-21 2005-02-24 U.S. Genomics, Inc. Quantum dots and methods of use thereof
US7351538B2 (en) * 2004-08-23 2008-04-01 U.S. Genomics Systems and methods for detecting and analyzing polymers
WO2006098772A2 (en) * 2004-10-13 2006-09-21 U.S. Genomics, Inc. Systems and methods for measurement optimization
WO2006044728A2 (en) * 2004-10-18 2006-04-27 U.S.Genomics, Inc. Methods for isolation of nucleic acids from prokaryotic spores
US20060160231A1 (en) * 2004-11-24 2006-07-20 U.S. Genomics, Inc. Linear analysis of polymers
US20060134679A1 (en) * 2004-12-17 2006-06-22 U.S. Genomics, Inc. Methods and compositions for acquiring information from unstretched polymer conformations
US20060292617A1 (en) * 2005-06-23 2006-12-28 U.S. Genomics, Inc. Methods and compositions for analysis of microRNA
US20070128083A1 (en) * 2005-07-18 2007-06-07 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
US20070042406A1 (en) * 2005-07-18 2007-02-22 U.S. Genomics, Inc. Diffusion mediated clean-up of a target carrier fluid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503334A (ja) * 1996-09-04 2002-01-29 テクニカル ユニバーシティ オブ デンマーク 粒子の分離と分析用のマイクロフローシステム
JP2002522780A (ja) * 1998-08-13 2002-07-23 ユー．エス．ゲノミクス ポリマーの光学的な特性決定
JP2003507026A (ja) * 1999-08-13 2003-02-25 ユー．エス．ジェノミクス，インコーポレーテッド ポリマーを引き伸ばす方法および装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020043874A (ja) * 2012-02-10 2020-03-26 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ 検体の解析方法
KR102887643B1 (ko) 2020-01-14 2025-11-19 포스 애널리터컬 에이/에스 유체역학적 포커싱 장치

Also Published As

Publication number Publication date
WO2004091795A3 (en) 2005-05-06
EP1620203A2 (en) 2006-02-01
US20050112606A1 (en) 2005-05-26
WO2004091795A2 (en) 2004-10-28

Similar Documents

Publication Publication Date Title
JP2006522940A (ja) マイクロチャネルにおけるポリマーの操作
US6696022B1 (en) Methods and apparatuses for stretching polymers
JP2003507026A (ja) ポリマーを引き伸ばす方法および装置
US7282130B2 (en) Apparatus and method for control of biopolymer translocation through a nanopore
Rems et al. Flow of DNA in micro/nanofluidics: From fundamentals to applications
Ermann et al. Promoting single-file DNA translocations through nanopores using electro-osmotic flow
US20060133957A1 (en) Device and method for fragmenting material by hydrodynamic shear
JP2006522940A5 (enExample)
US20220056393A1 (en) Methods and systems for intracellular delivery
US11998885B2 (en) Fluidic devices with reaction wells and constriction channels and uses thereof
CN102905788A (zh) 包括电极组的用于控制dna传输通过纳米通道的纳米流体场效应装置
CN109070080A (zh) 颗粒分离装置和颗粒分离方法
KR20160130380A (ko) 생체분자를 서열화하기 위한 디바이스, 시스템 및 방법
US20200110081A1 (en) Devices and Methods for Detection and Quantification of Immunological Proteins, Pathogenic and Microbial Agents and Cells
Wang et al. Mechanisms of flow-induced polymer translocation
Young et al. Integrated in-plane nanofluidic devices for resistive-pulse sensing
CN101631617B (zh) 基于致动器元件的微流体系统
US11872561B2 (en) Systems for stretching polynucleotide structures
JP2014020837A (ja) ポリヌクレオチド配列決定方法
Han et al. Effect of non-uniform fields on DNA entering nano-channel
Wang et al. Field-driven polyelectrolyte–polymer collisions in nanochannels
Sharma Translocation of polymers through a wide-open conical pore
Sharma Polymer Translocation Through Conical Pores
CN120905359A (zh) 基于纳米磁珠的游离胎儿dna富集及定量分析方法
Dwivedi et al. Polymer translocation: Effects of confinement

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070404

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070404

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20090515

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091013

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100112

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100119

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100630