JP2006507839A5 - - Google Patents

Info

Publication number

JP2006507839A5

JP2006507839A5 JP2004557456A JP2004557456A JP2006507839A5 JP 2006507839 A5 JP2006507839 A5 JP 2006507839A5 JP 2004557456 A JP2004557456 A JP 2004557456A JP 2004557456 A JP2004557456 A JP 2004557456A JP 2006507839 A5 JP2006507839 A5 JP 2006507839A5

Authority

JP

Japan

Prior art keywords

antibody

hinge region

composition

exogenous

modified

Prior art date

2003-11-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 38
• 239000000203 mixture Substances 0.000 claims 30
• 241000124008 Mammalia Species 0.000 claims 17
• 230000009261 transgenic effect Effects 0.000 claims 15
• 235000013336 milk Nutrition 0.000 claims 14
• 239000008267 milk Substances 0.000 claims 14
• 210000004080 milk Anatomy 0.000 claims 14
• 210000002919 epithelial cell Anatomy 0.000 claims 9
• 239000012634 fragment Substances 0.000 claims 9
• 235000001014 amino acid Nutrition 0.000 claims 8
• 150000001413 amino acids Chemical class 0.000 claims 8
• 230000013595 glycosylation Effects 0.000 claims 6
• 238000006206 glycosylation reaction Methods 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 239000000427 antigen Substances 0.000 claims 4
• 102000036639 antigens Human genes 0.000 claims 4
• 108091007433 antigens Proteins 0.000 claims 4
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
• 150000007523 nucleic acids Chemical group 0.000 claims 4
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 4
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 4
• 210000004602 germ cell Anatomy 0.000 claims 3
• 210000001082 somatic cell Anatomy 0.000 claims 3
• 108091026890 Coding region Proteins 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 241000283690 Bos taurus Species 0.000 claims 1
• 241000283707 Capra Species 0.000 claims 1
• 102000004407 Lactalbumin Human genes 0.000 claims 1
• 108090000942 Lactalbumin Proteins 0.000 claims 1
• 102000008192 Lactoglobulins Human genes 0.000 claims 1
• 108010060630 Lactoglobulins Proteins 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 241000699670 Mus sp. Species 0.000 claims 1
• 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
• 241001494479 Pecora Species 0.000 claims 1
• 241000700159 Rattus Species 0.000 claims 1
• 241000282887 Suidae Species 0.000 claims 1
• 102000007544 Whey Proteins Human genes 0.000 claims 1
• 108010046377 Whey Proteins Proteins 0.000 claims 1
• 239000005018 casein Substances 0.000 claims 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
• 235000021240 caseins Nutrition 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 235000021119 whey protein Nutrition 0.000 claims 1