JP2006506994A - リン酸化ndrキナーゼ - Google Patents

リン酸化ndrキナーゼ Download PDF

Info

Publication number
JP2006506994A
JP2006506994A JP2004554468A JP2004554468A JP2006506994A JP 2006506994 A JP2006506994 A JP 2006506994A JP 2004554468 A JP2004554468 A JP 2004554468A JP 2004554468 A JP2004554468 A JP 2004554468A JP 2006506994 A JP2006506994 A JP 2006506994A
Authority
JP
Japan
Prior art keywords
ndr
polypeptide
amino acid
kinase
ndr1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004554468A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006506994A5 (https=
Inventor
サムエル・ヨーゼフ・ビッヒゼル
ブライアン・アーサー・ヘミングズ
マリオ・ラインハルト・シュテゲルト
ラスティスラフ・タマスコヴィッチ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Original Assignee
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research filed Critical Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Publication of JP2006506994A publication Critical patent/JP2006506994A/ja
Publication of JP2006506994A5 publication Critical patent/JP2006506994A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2004554468A 2002-11-26 2003-11-25 リン酸化ndrキナーゼ Pending JP2006506994A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0227562.6A GB0227562D0 (en) 2002-11-26 2002-11-26 Phorphorylated NDR Kinase
PCT/EP2003/013251 WO2004048576A1 (en) 2002-11-26 2003-11-25 Phosphorylated ndr kinase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010160462A Division JP2010279371A (ja) 2002-11-26 2010-07-15 リン酸化ndrキナーゼ

Publications (2)

Publication Number Publication Date
JP2006506994A true JP2006506994A (ja) 2006-03-02
JP2006506994A5 JP2006506994A5 (https=) 2010-09-09

Family

ID=9948532

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004554468A Pending JP2006506994A (ja) 2002-11-26 2003-11-25 リン酸化ndrキナーゼ
JP2010160462A Withdrawn JP2010279371A (ja) 2002-11-26 2010-07-15 リン酸化ndrキナーゼ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010160462A Withdrawn JP2010279371A (ja) 2002-11-26 2010-07-15 リン酸化ndrキナーゼ

Country Status (6)

Country Link
US (1) US8008452B2 (https=)
EP (1) EP1567646A1 (https=)
JP (2) JP2006506994A (https=)
AU (1) AU2003286181A1 (https=)
GB (1) GB0227562D0 (https=)
WO (1) WO2004048576A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642569B2 (en) 2009-01-21 2014-02-04 The General Hospital Corporation Methods for expansion of hematopoietic stem and progenitor cells
US20230193267A1 (en) * 2021-10-19 2023-06-22 Animatus Biosciences, Inc. Cardiac cell proliferation by administering inhibitors of sav1, nf2, mob1 and/or mutant srf
CN119497621A (zh) 2022-06-20 2025-02-21 杏林制药株式会社 纤维化疾病治疗用医药组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4388296A (en) 1994-12-22 1996-07-10 Novartis Ag Nuclear protein serine/threonine kinases
PT862622E (pt) 1995-11-16 2005-01-31 Novartis Ag Metodo de rastreio para compostos que interagem com proteina cinase rac
GB9921121D0 (en) 1999-09-07 1999-11-10 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
GB0227562D0 (en) 2002-12-31
WO2004048576A1 (en) 2004-06-10
AU2003286181A1 (en) 2004-06-18
US8008452B2 (en) 2011-08-30
US20060172374A1 (en) 2006-08-03
JP2010279371A (ja) 2010-12-16
EP1567646A1 (en) 2005-08-31

Similar Documents

Publication Publication Date Title
Wang et al. Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the ϵ‐subunit and their functions in vivo
Tang et al. Two distinct mechanisms for negative regulation of the Wee1 protein kinase.
Brunet et al. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
Chen et al. The casein kinase II β subunit binds to Mos and inhibits Mos activity
Vitari et al. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate
Watanabe et al. Regulation of the human WEE1Hu CDK tyrosine 15‐kinase during the cell cycle.
Kollewe et al. Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
Scholz et al. Autoactivation of transforming growth factor β-activated kinase 1 is a sequential bimolecular process
Donella-Deana et al. Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity
Kirchhefer et al. Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41
Yamashita et al. Molecular mechanisms of the activation of maturation-promoting factor during goldfish oocyte maturation
Kuma et al. Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta
Oe et al. Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes
JP2000502097A (ja) タンパク質合成の制御、および作用薬のスクリーニング法
JP2008115164A (ja) IκBキナーゼ、そのサブユニット、およびこれらを使用する方法
Nagy et al. Activation of AtMPK9 through autophosphorylation that makes it independent of the canonical MAPK cascades.
Wolff et al. Interaction of casein kinase 1 delta (CK1δ) with the light chain LC2 of microtubule associated protein 1A (MAP1A)
US20070196883A1 (en) Enzyme
AU726294B2 (en) Ikk-alpha proteins, nucleic acids and methods
King et al. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1
Phin et al. Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1
MURÁNYI et al. Identification and localization of myosin phosphatase in human platelets
WO2000019205A1 (en) Inhibition of pak activation of raf-1
JP2010279371A (ja) リン酸化ndrキナーゼ
Kurioka et al. Molecular cloning and characterization of a novel protein serine/threonine kinase highly expressed in mouse embryo

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061025

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061025

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090811

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091111

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091118

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091211

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100112

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100316

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20100715

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20100906

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20101105