JP2006502231A - 大量失血を被っている患者の処置方法 - Google Patents
大量失血を被っている患者の処置方法 Download PDFInfo
- Publication number
- JP2006502231A JP2006502231A JP2004546786A JP2004546786A JP2006502231A JP 2006502231 A JP2006502231 A JP 2006502231A JP 2004546786 A JP2004546786 A JP 2004546786A JP 2004546786 A JP2004546786 A JP 2004546786A JP 2006502231 A JP2006502231 A JP 2006502231A
- Authority
- JP
- Japan
- Prior art keywords
- hemoglobin
- solution
- polymerized
- molecular weight
- hemoglobin solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 79
- 239000008280 blood Substances 0.000 title claims abstract description 79
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 259
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 259
- 238000000034 method Methods 0.000 claims abstract description 75
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- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
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- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 description 1
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- 150000003904 phospholipids Chemical class 0.000 description 1
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- 238000006068 polycondensation reaction Methods 0.000 description 1
- 108010050918 polyhemoglobin Proteins 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
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- 239000001103 potassium chloride Substances 0.000 description 1
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- WHOMFKWHIQZTHY-UHFFFAOYSA-N pyridoxine 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(CO)=C1O WHOMFKWHIQZTHY-UHFFFAOYSA-N 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41593502P | 2002-10-03 | 2002-10-03 | |
| PCT/US2003/031377 WO2004037279A1 (en) | 2002-10-03 | 2003-10-03 | Method for treating patients with massive blood loss |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006502231A true JP2006502231A (ja) | 2006-01-19 |
| JP2006502231A5 JP2006502231A5 (OSRAM) | 2006-10-05 |
Family
ID=32176456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004546786A Pending JP2006502231A (ja) | 2002-10-03 | 2003-10-03 | 大量失血を被っている患者の処置方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7291592B2 (OSRAM) |
| EP (1) | EP1553968A4 (OSRAM) |
| JP (1) | JP2006502231A (OSRAM) |
| CN (1) | CN1703235A (OSRAM) |
| AU (1) | AU2003272827B2 (OSRAM) |
| CA (1) | CA2499459A1 (OSRAM) |
| MX (1) | MXPA05003340A (OSRAM) |
| NO (1) | NO20051390L (OSRAM) |
| RU (1) | RU2325924C2 (OSRAM) |
| WO (1) | WO2004037279A1 (OSRAM) |
| ZA (1) | ZA200502307B (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050049707A1 (en) * | 2003-08-29 | 2005-03-03 | Ferree Bret A. | Cemented artificial disc replacements |
| EP1471821B1 (en) * | 2002-01-15 | 2013-06-26 | Board Of Regents, The University Of Texas System | Compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures |
| EP1978802A2 (en) * | 2006-01-24 | 2008-10-15 | Northfield Laboratories, Inc. | Polymerized hemoglobin media and its use in isolation and transplantation of islet cells |
| US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
| EP2046371A2 (en) * | 2006-07-17 | 2009-04-15 | Novo Nordisk Health Care AG | Factor viia analogues with increased activity for treating thrombocytopenia |
| RU2361608C1 (ru) * | 2008-03-18 | 2009-07-20 | Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" | Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты) |
| RU2452519C1 (ru) * | 2011-03-25 | 2012-06-10 | Государственное учреждение здравоохранения Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения г. Москвы | Способ компенсации глобулярного объема крови и иммуномодулирующего воздействия при трансплантации |
| AU2018304174B2 (en) | 2017-07-18 | 2025-07-10 | VirTech Bio, Inc. | Blood substitutes comprising hemoglobin and methods of making |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194590A (en) * | 1986-06-20 | 1993-03-16 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US4826811A (en) * | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5464814A (en) * | 1986-06-20 | 1995-11-07 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5854209A (en) | 1995-03-23 | 1998-12-29 | Biopure Corporation | Method for oxygenating tissue having reduced red blood cell flow |
| US5084558A (en) * | 1987-10-13 | 1992-01-28 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
| US5955581A (en) * | 1986-11-10 | 1999-09-21 | Biopure Corporation | Method for producing a stable polymerized hemoglobin blood-substitute |
| US20020065211A1 (en) * | 1995-03-23 | 2002-05-30 | Biopure Corporation | Increasing function of organs having reduced red blood cell flow |
| US5691452A (en) * | 1995-03-23 | 1997-11-25 | Biopure Corporation | Method for preserving a hemoglobin blood substitute |
| ATE447324T1 (de) * | 1995-03-23 | 2009-11-15 | Biopure Corp | Stabiles blutersatzmittel mit polymerisiertem hämoglobin |
| US6271351B1 (en) * | 1995-03-23 | 2001-08-07 | Biopure Corporation | Method for preserving a hemoglobin blood substitute |
| US6288027B1 (en) * | 1995-03-23 | 2001-09-11 | Biopure Corporation | Preserving a hemoglobin blood substitute with a transparent overwrap |
| US5895810A (en) * | 1995-03-23 | 1999-04-20 | Biopure Corporation | Stable polymerized hemoglobin and use thereof |
| US6150507A (en) * | 1995-03-23 | 2000-11-21 | Biopure Corporation | Method for producing a purified hemoglobin product |
| US5691453A (en) * | 1995-06-07 | 1997-11-25 | Biopure Corporation | Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC |
| PT928294E (pt) * | 1996-03-28 | 2003-10-31 | Northfield Lab | Metodo e dispositivo para a preparacao de um substituto acelular dos globulos vermenlhos do sangue |
| US5890852A (en) * | 1998-03-17 | 1999-04-06 | Emerson Electric Company | Thread cutting die and method of manufacturing same |
-
2003
- 2003-10-03 MX MXPA05003340A patent/MXPA05003340A/es active IP Right Grant
- 2003-10-03 AU AU2003272827A patent/AU2003272827B2/en not_active Expired - Fee Related
- 2003-10-03 JP JP2004546786A patent/JP2006502231A/ja active Pending
- 2003-10-03 CN CNA2003801009126A patent/CN1703235A/zh active Pending
- 2003-10-03 EP EP03755029A patent/EP1553968A4/en not_active Withdrawn
- 2003-10-03 US US10/678,927 patent/US7291592B2/en not_active Expired - Fee Related
- 2003-10-03 CA CA002499459A patent/CA2499459A1/en not_active Abandoned
- 2003-10-03 RU RU2005113240/14A patent/RU2325924C2/ru not_active IP Right Cessation
- 2003-10-03 WO PCT/US2003/031377 patent/WO2004037279A1/en not_active Ceased
-
2005
- 2005-03-16 NO NO20051390A patent/NO20051390L/no not_active Application Discontinuation
- 2005-03-18 ZA ZA2005/02307A patent/ZA200502307B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003272827B2 (en) | 2009-03-19 |
| NO20051390L (no) | 2005-05-30 |
| RU2325924C2 (ru) | 2008-06-10 |
| US7291592B2 (en) | 2007-11-06 |
| MXPA05003340A (es) | 2005-07-05 |
| EP1553968A4 (en) | 2009-06-24 |
| EP1553968A1 (en) | 2005-07-20 |
| CA2499459A1 (en) | 2004-05-06 |
| ZA200502307B (en) | 2005-11-30 |
| RU2005113240A (ru) | 2005-12-10 |
| AU2003272827A1 (en) | 2004-05-13 |
| WO2004037279A1 (en) | 2004-05-06 |
| US20040067876A1 (en) | 2004-04-08 |
| CN1703235A (zh) | 2005-11-30 |
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