JP2006316001A5

JP2006316001A5 -

Info

Publication number: JP2006316001A5
Application number: JP2005140550A
Authority: JP
Filing date: 2005-05-13
Publication date: 2008-06-26
Anticipated expiration: 2025-05-13

Claims

A naphthoquinone derivative compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof.

(In the formula, when R ₃ is an aryl alcohol group or an alkylcarbonyl group, R ₁ is a hydrogen atom, an alkyl group, a hydroxyl group, an alkoxyl group, or a hydroxyalkyl group, and R ₂ is a hydroxyl group or an acyloxy group. Or R ₄ is an acyl group, a hydroxyalkyl group, a hydroxyalkenyl group, a carboxyl group, an alkoxycarbonyl group, an alkoxyalkyl group, an alkoxyalkenyl group, a phenoxyalkyl group, a phenoxyalkenyl group, a carboxyalkenyl group, or an alkoxycarbonyl group. An alkenyl group, an acyloxyalkenyl group, a hydroxyalkyloxirane alkyl group, an alkoxyalkyloxiranealkyl group, a dihydroxyalkyl group, a hydroxyalkoxyalkyl group, an oxirane group, or 2 A dimethane-1,3-dioxane-4-alkyl group,
In the formula, when R ₄ is an alkynyloxyalkyl group or a butyldimethylsilyloxyalkenyl group, R ₁ is a hydrogen atom, an alkyl group, a hydroxyl group, an alkoxyl group, or a hydroxyalkyl group, and R ₂ is a hydroxyl group. , An acyloxy group, or an alkoxyl group, and R ₃ is a hydrogen atom, a hydroxyalkyl group, a halogen atom, or an aryl alcohol group,
In the formula, when R ₁ is an acyloxy group, R ₂ is a hydroxyl group, an acyloxy group, or an alkoxyl group, R ₃ is a hydrogen atom, a hydroxyalkyl group, or a halogen atom, and R ₄ is an acyl group. , Hydroxyalkyl group, hydroxyalkenyl group, carboxyl group, alkoxycarbonyl group, alkoxyalkyl group, alkoxyalkenyl group, phenoxyalkyl group, phenoxyalkenyl group, carboxyalkenyl group, alkoxycarbonylalkenyl group, acyloxyalkenyl group, hydroxyalkyloxirane alkyl group An alkoxyalkyloxirane alkyl group, a dihydroxyalkyl group, a hydroxyalkoxyalkyl group, an oxirane group, or a 2-dimethane-1,3-dioxane-4-alkyl group,
In the formula, when R ₁ and R ₂ are methoxy groups and R ₄ is a hydroxybut-2-enyl group, R ₃ is a hydroxyethyl group, a hydroxypropyl group, or a hydroxyhexyl group,
In the formula, when R ₂ is a methoxy group, R ₃ is a hydrogen atom, and R ₄ is a methoxymethyl group, R ₁ is a hydroxyl group,
In the formula, when R ₁ and R ₂ are methoxy groups and R ₃ is a hydrogen atom, R ₄ is a hexyloxymethyl group,
R ₃ and R ₄ do not form a ring. )

A naphthoquinone derivative compound represented by the following general formula (II) or a pharmacologically acceptable salt thereof.

(Wherein R ₅ is a hydrogen atom or an alkyl group, R ₆ is a hydroxyethyl group, a hydroxypropyl group, a hydroxyhexyl group, an aryl alcohol group, or an alkylcarbonyl group, and R ₇ is a hydrogen atom, an acyl group, Or, it is a butyldimethylsilyl group, and the R ₆ and the R ₇ do not form a ring.)

A naphthoquinone derivative compound represented by the following general formula (III) or a pharmacologically acceptable salt thereof.

(In the formula, R ₈ is a hydrogen atom or an acyl group.)

A naphthoquinone derivative compound represented by the following general formula (IV) or a pharmacologically acceptable salt thereof.

(In the formula, R ₉ is a propyl group, a butyl group, a hexyl group, or an alkynyloxyalkyl group.)

The naphthoquinone derivative compound or a pharmacologically acceptable salt thereof according to claim 2, wherein the compound is a compound represented by the following formulas (a) to (j).

The naphthoquinone derivative compound or a pharmacologically acceptable salt thereof according to claim 3, wherein the compound is a compound represented by the following formula (k) or (l).

The naphthoquinone derivative compound or a pharmacologically acceptable salt thereof according to claim 4, wherein the compound is a compound represented by the following formulas (m) to (p).