JP2006298878A - Anti-cancer agent lesion-preventing agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine effective for preventing health lesions expressed as side effects caused by anti-cancer agents. <P>SOLUTION: This anti-cancer agent lesion-preventing agent contains a yeast containing an anti-oxidizing metal as an active ingredient. The anti-cancer agent lesion-preventing agent contains Saccharomyces cerevisiae yeast containing at least one of Mn, Zn, Fe, Cu and Se as an active ingredient. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a drug effective for preventing (suppressing or alleviating) a health disorder that appears as a side effect resulting from administration of an anticancer drug.

  In fact, patients undergoing anticancer drug treatment for cancer suffer from health problems such as vomiting and diarrhea due to side effects. In anticancer drug treatment, the dose is limited to suppress side effects. Nevertheless, the development of drugs that effectively prevent health problems, which are side effects of anticancer drugs, is an urgent research subject. In addition, the maximum dose of an anticancer drug in current anticancer drug treatment is limited by a health disorder caused by a side effect. Therefore, if it becomes possible to suppress side effects in anticancer drug treatment, the dose of the anticancer drug can be increased, and it is considered that the cure rate of cancer by the anticancer drug is improved.

  Currently, no preventive drugs that effectively suppress the side effects of anticancer drugs have been developed, and the current situation is that the symptomatic treatment with antidiarrheal agents alone cannot eliminate the patient's pain. .

  The present inventors have previously studied drugs that effectively suppress the health disorders that are side effects of cancer treatment with anticancer drugs, developed chromanol glycosides, and announced the effects of these inhibitors ( The 9th Japanese Cancer Treatment Sensitization Study Group, Kyoto, 2003).

  In addition, there are patent applications in which yeast, further metal-containing yeast and its extract are effective for cancer treatment and health maintenance (Patent Document 1, Patent Document 2, Patent Document 3, and Patent Document 4). However, these patent documents do not prevent health problems caused by anticancer agents.

Japanese Patent Laid-Open No. 9-77684 JP-A-9-124438 Japanese Patent Laid-Open No. 2003-198 JP 2003-61618 A

  It is an object of the present invention to provide an effective drug for preventing a health disorder that appears as a side effect caused by an anticancer drug.

  As a result of studying Saccharomyces cerevisiae yeast containing selenium (Se), which is known as an antioxidant metal, the present inventors have confirmed that an antioxidant metal-containing yeast can effectively prevent health problems in anticancer drug treatment of cancer. The headline and the present invention were completed.

  That is, the present invention is effective for a prophylactic agent for an anticancer agent disorder comprising yeast containing an antioxidant metal as an active ingredient, specifically, Saccharomyces cerevisiae yeast containing at least one of Mn, Zn, Fe, Cu and Se. It is related with the preventive agent of the anticancer agent disorder used as a component.

  Although there are some unclear points about the mechanism of preventing health disorders caused by anticancer agents by specific yeast used in the present invention, specific antioxidant metal-containing yeasts protect the liver from detoxification function damage by anticancer agents, or are generated by anticancer agents. It is thought that the cell damage caused by free radicals is effectively protected.

  When using the anticancer agent disorder preventive agent of the present invention, it is possible to effectively prevent a health disorder (side effect) that appears as a side effect resulting from administration of an anticancer agent for cancer treatment.

  Saccharomyces cerevisiae yeast used in the present invention is widely used for fermentation of bread, beer, wine, liquor, miso, soy sauce, natto, etc. as baker's yeast, brewer's yeast, etc. It is also included in familiar fermented foods. Furthermore, Saccharomyces cerevisiae yeast containing an antioxidant metal is a safe substance widely marketed as a health food additive or cosmetic ingredient.

  In this invention, since it does not mix | blend yeast for the purpose of making it ferment, it does not ask | require whether it has fermentation activity. As a method for inactivating the fermentation activity of yeast, a method in which it is allowed to stand in oxygen for a long time for natural oxidation, a method in which it is heated at a temperature of about 100 ° C. for several minutes, a method in which radiation is irradiated, etc. are known. .

  Examples of the antioxidant metal include at least one of Mn, Zn, Fe, Cu, and Se, and Se is particularly preferable because of its high antioxidant activity.

  The antioxidant metal-containing Saccharomyces cerevisiae yeast is produced by growing Saccharomyces cerevisiae yeast in a medium supplemented with an antioxidant metal compound.

  Formulations include powders, liquids, tablets, and the like, which are formulated using pharmacologically acceptable excipients as appropriate, but can also be administered as soft drinks such as lemon tea in tea.

  The administration method is sufficiently effective by oral administration of an aqueous solution, but may be intravenous administration or the like.

  The dose is 300 to 900 mg / kg body weight for oral administration and 100 to 300 mg / kg body weight for intravenous administration.

  Since the present invention is used as a prophylactic agent, it is desirable to administer it up to 30 minutes before administration of the anticancer agent.

  Anticancer agents targeted by the present invention include alkyl agents such as cyclophosphamide and melphalan, antimetabolites such as methotrexate and fluorouracil, anticancer antibiotics such as mitomycin and adriamycin, and anticancer plants such as vincristine and etoposide. In addition to DNA synthesis inhibitors such as derived substances and cisplatin, Gemzar and taxane anticancer agents are cytotoxic anticancer agents that develop side effects when administered.

  EXAMPLES Next, the present invention will be specifically described with reference to examples. However, the present invention is not limited only to these examples.

Example 1
Yeast suspension (0.3 ml, 750 mg / kg body weight) was injected into the peritoneal cavity of 8-9 week old female BDF mice (body weight 20-22 g: 10 mice / group), and cyclophosphine 30 minutes after the injection. Famide (CPA) (600 mg / kg body weight) was administered into the peritoneal cavity, and the average survival time was examined (in the control group, 0.5% methylcellulose was administered into the abdominal cavity). The case where the dose of CPA was changed (360 mg / kg body weight) was also examined. The results are shown in Table 1.

  The selenium yeast suspension is a suspension obtained by adding Saccharomyces cerevisiae yeast (hereinafter referred to as “selenium yeast”) containing 0.2% selenium to physiological saline to a concentration of 50 mg / ml.

Example 2
Selenium yeast suspension (0.3 ml, 750 mg / kg body weight) was injected into the peritoneal cavity of 8-9 week old female BDF mice (body weight 20-22 g: 10 mice / group), and cisplatin 30 minutes after the injection. (CDDP) (12 mg / kg body weight) was administered into the peritoneal cavity and the average survival time was examined (in the control group, 0.5% methylcellulose was administered to the abdominal cavity). The results are shown in Table 2.

Claims (2)

The preventive agent of an anticancer drug disorder which uses the yeast containing an antioxidant metal as an active ingredient. The preventive agent for an anticancer agent disorder according to claim 1, wherein the yeast containing an antioxidant metal is a Saccharomyces cerevisiae yeast containing at least one of Mn, Zn, Fe, Cu and Se.