JP2006271815A - Method and system for measuring oxygen saturation of skin - Google Patents

Method and system for measuring oxygen saturation of skin Download PDF

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JP2006271815A
JP2006271815A JP2005098290A JP2005098290A JP2006271815A JP 2006271815 A JP2006271815 A JP 2006271815A JP 2005098290 A JP2005098290 A JP 2005098290A JP 2005098290 A JP2005098290 A JP 2005098290A JP 2006271815 A JP2006271815 A JP 2006271815A
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Nobutoshi Kojima
伸俊 小島
Shuichi Akasaki
秀一 赤崎
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Kao Corp
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Abstract

<P>PROBLEM TO BE SOLVED: To execute both of a visual observation of the surface state of the skin and a measurement of the oxygen saturation of the skin using a skin magnified image pickup device. <P>SOLUTION: This method for measuring the oxygen saturation of the skin acquires an internal reflecting light image of a subject's skin, extracts a hemoglobin component image from the internal reflecting light image by an independent componential analysis, calculates a standard deviation or an average value of the concentration for every pixel of the hemoglobin component image, and evaluates the oxygen saturation of the skin using the standard deviation or the average value. Alternatively, a relational expression between the standard deviation or the average value of the concentration for every pixel of the hemoglobin component image and the oxygen saturation measured by spectrometry is acquired previously from the measurement of a plurality of skins and the oxygen saturation of the skin is measured from the hemoglobin component image of an arbitrary skin. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

本発明は、肌画像から肌の酸素飽和度を計測する方法及びシステムに関する。   The present invention relates to a method and system for measuring oxygen saturation of skin from a skin image.

従来、肌のきめの粗さ、毛穴状態、色むら等の表面状態を視覚的に観察し、評価するために、肌表面を拡大観察する肌拡大画像撮影装置が使用されている（特許文献１）。   2. Description of the Related Art Conventionally, in order to visually observe and evaluate surface conditions such as skin roughness, pores, and color unevenness, a magnified skin imaging apparatus that magnifies and observes the skin surface has been used (Patent Document 1). ).

一方、肌表面から微小循環系までの領域の特定波長の吸光度を測定することにより、メラニン色素や、肌の血行状態の指標となる酸化型ヘモグロビンあるいは還元型ヘモグロビンの濃度を算出する方法（特許文献２）や、かかる測定を、コードレスプローブを用いて行う装置（特許文献３）が提案されている。   On the other hand, a method of calculating the concentration of melanin pigment, oxidized hemoglobin or reduced hemoglobin, which is an indicator of the blood circulation state of the skin, by measuring the absorbance at a specific wavelength in the region from the skin surface to the microcirculatory system (Patent Document) 2) and an apparatus (Patent Document 3) that performs such measurement using a cordless probe has been proposed.

特許文献２に記載の方法によれば、ヘモグロビンの酸素飽和度に基づく光学的特性を求めることができる。   According to the method described in Patent Document 2, optical characteristics based on the oxygen saturation of hemoglobin can be obtained.

しかしながら、肌の酸素飽和度の計測、あるいは酸化型ないし還元型ヘモグロビンの濃度の算出のために行う従来の分光測定は、点計測を主体とする。一方、肌表面の拡大観察を行う肌拡大画像撮影装置は、ある程度の面積を計測対象とする。そのため、従来の手法では、肌拡大画像撮影装置で得られる画像から肌の酸素飽和度を計測することはできない。そこで、表面状態の拡大観察と酸素飽和度の計測との双方を行い、肌を総合的に評価するためには、肌拡大画像撮影装置と分光測定装置との双方を別個に備えなくてはならず、また、分光測定する部位を肌拡大画像撮影装置で探索することもできない。   However, the conventional spectroscopic measurement performed for measuring the oxygen saturation of the skin or calculating the concentration of oxidized or reduced hemoglobin is mainly point measurement. On the other hand, a skin magnified image photographing apparatus that performs magnified observation of the skin surface has a certain area as a measurement target. Therefore, with the conventional method, it is not possible to measure the oxygen saturation level of the skin from the image obtained by the skin magnified image photographing device. Therefore, in order to perform both surface magnification observation and oxygen saturation measurement, and to comprehensively evaluate the skin, both the skin magnification image capturing device and the spectroscopic measurement device must be provided separately. In addition, it is not possible to search for a part to be subjected to spectroscopic measurement with a skin magnified image photographing device.

特開平６−３１３７０８号公報JP-A-6-313708 特開平１０−１２７５８５号公報Japanese Patent Laid-Open No. 10-127585 特開２００１−７０２５１号公報JP 2001-70251 A

上述の従来技術に対し、本発明は、肌拡大画像撮影装置を用いて、肌の表面状態の視覚的観察と肌の酸素飽和度の計測の双方を行えるようにし、肌の表面状態を観察、探索しながら所望の部位の酸素飽和度を計測できるようにすることを目的とする。   In contrast to the above-described conventional technology, the present invention enables both visual observation of the skin surface state and measurement of the oxygen saturation of the skin using the skin enlargement image photographing device, and observes the skin surface state. An object is to enable measurement of oxygen saturation at a desired site while searching.

本発明者らは、肌の内部反射光画像から抽出したヘモグロビン成分画像における濃度ムラは、還元型ヘモグロビン濃度の高い鬱血部位を反映しており、このヘモグロビン成分画像の濃度ムラを統計量として数値化すると、得られる数値は、従前の分光測定法で計測される肌の酸素飽和度と高い相関性を有することを見出した。   The present inventors reflected density unevenness in a hemoglobin component image extracted from the internal reflection light image of the skin reflecting a congested region having a high reduced hemoglobin concentration, and the density unevenness of the hemoglobin component image was quantified as a statistic. Then, it discovered that the numerical value obtained had high correlation with the oxygen saturation degree of the skin measured by the conventional spectroscopic measurement method.

即ち、本発明は、被験者の肌の内部反射光画像を取得し、
該内部反射光画像から独立成分分析によりヘモグロビン成分画像を抽出し、
該ヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出し、
該標準偏差又は平均値を用いて肌の酸素飽和度を評価する酸素飽和度評価方法を提供する。 That is, the present invention acquires an internally reflected light image of the subject's skin,
Extracting a hemoglobin component image from the internally reflected light image by independent component analysis,
Calculate the standard deviation or average value of the density for each pixel of the hemoglobin component image,
Provided is an oxygen saturation evaluation method for evaluating skin oxygen saturation using the standard deviation or average value.

また、本発明は、複数の肌について、分光測定法により酸素飽和度を計測すると共に、
上述の方法によりヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出し、
該標準偏差又は平均値と前記酸素飽和度との関係式を取得し、
任意の肌について、内部反射光画像から独立成分分析によりヘモグロビン成分画像を抽出し、
該ヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出し、
前記関係式を用いて該標準偏差又は平均値から当該任意の肌の酸素飽和度を算出する酸素飽和度計測方法を提供する。 In addition, the present invention measures oxygen saturation by spectrophotometry for a plurality of skins,
Calculate the standard deviation or average value of the density for each pixel of the hemoglobin component image by the above method,
Obtain a relational expression between the standard deviation or average value and the oxygen saturation,
For any skin, extract the hemoglobin component image from the internal reflection image by independent component analysis,
Calculate the standard deviation or average value of the density for each pixel of the hemoglobin component image,
Provided is an oxygen saturation measurement method for calculating the oxygen saturation of an arbitrary skin from the standard deviation or average value using the relational expression.

さらに、本発明は、
(i)肌の内部反射光画像を形成することのできる画像形成手段、
(ii)複数の肌について、ヘモグロビン成分画像から算出したピクセル毎の濃度の標準偏差又は平均値と、分光測定法による酸素飽和度との関係式を記憶する手段、
任意の肌について、内部反射光画像から独立成分分析によりヘモグロビン成分画像を抽出する手段、
ヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出する手段、及び
前記関係式を用いて該標準偏差又は平均値から当該任意の肌の酸素飽和度を算出する手段を備えた演算装置、
(iii)演算装置が算出した任意の肌の酸素飽和度を表示する表示手段
を備えた酸素飽和度計測システムを提供する。 Furthermore, the present invention provides
(i) image forming means capable of forming an internally reflected light image of the skin,
(ii) means for storing a relational expression between a standard deviation or an average value of the concentration for each pixel calculated from a hemoglobin component image and oxygen saturation by a spectroscopic measurement method for a plurality of skins;
Means for extracting a hemoglobin component image from an internally reflected light image by independent component analysis for any skin;
Arithmetic unit comprising means for calculating standard deviation or average value of density of each pixel of hemoglobin component image, and means for calculating oxygen saturation of arbitrary skin from the standard deviation or average value using the relational expression ,
(iii) Provided is an oxygen saturation measurement system provided with display means for displaying the oxygen saturation of an arbitrary skin calculated by an arithmetic device.

本発明の酸素飽和度評価方法によれば、肌の内部反射光画像から独立成分分析によりヘモグロビン成分画像を抽出し、そのヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出し、算出された標準偏差又は平均値を用いて肌の酸素飽和度を評価するので、従来、酸素飽和度の計測に必要とされていた分光測定装置を使用することなく、肌拡大画像撮影装置を用いて肌の拡大画像を観察しつつ、所望の部位の酸素飽和度の変化を評価することができる。   According to the oxygen saturation evaluation method of the present invention, a hemoglobin component image is extracted from the internal reflection light image of the skin by independent component analysis, and a standard deviation or an average value of the concentration of each pixel of the hemoglobin component image is calculated and calculated. Since the oxygen saturation of the skin is evaluated using the standard deviation or the average value, it is possible to use the enlarged skin image capturing device without using the spectroscopic measurement device that has been conventionally required for measuring the oxygen saturation. While observing an enlarged image of the skin, it is possible to evaluate a change in oxygen saturation at a desired site.

また、本発明の酸素飽和度計測方法によれば、ヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値と、分光測定装置で計測される酸素飽和度との関係式を用いるので、任意の肌のヘモグロビン成分画像からその肌の酸素飽和度を計測することができる。   Moreover, according to the oxygen saturation measurement method of the present invention, since the relational expression between the standard deviation or average value of the concentration of each pixel of the hemoglobin component image and the oxygen saturation measured by the spectrometer is used, any It is possible to measure the oxygen saturation of the skin from the hemoglobin component image of the skin.

さらに、本発明の酸素飽和度計測システムによれば、肌拡大画像撮影装置を用いて被験者から肌の内部反射光画像を取得し、その画像から肌の酸素飽和度を算出して被験者に示すので、肌拡大画像撮影装置を用いて得られる通常の表面状態の観察結果と共に、酸素飽和度の計測結果を被験者に示し、うっ血状態を観察提示することにより、肌ケアのアドバイスを効果的に行うことができる。   Furthermore, according to the oxygen saturation measurement system of the present invention, the skin internal reflection light image is obtained from the subject using the skin enlargement image capturing device, and the skin oxygen saturation is calculated from the image and shown to the subject. In addition to the observation results of the normal surface condition obtained using the skin enlargement imaging device, the oxygen saturation measurement result is shown to the subject, and the congestion state is observed and presented to effectively provide skin care advice. Can do.

以下、図面を参照しつつ、本発明を詳細に説明する。   Hereinafter, the present invention will be described in detail with reference to the drawings.

図１は、本発明の酸素飽和度評価方法及び酸素飽和度計測方法の一態様のフローシートであり、図２は、これらの方法を実施する酸素飽和度計測システムの一態様のシステム構成図である。   FIG. 1 is a flow sheet of one aspect of the oxygen saturation evaluation method and oxygen saturation measurement method of the present invention, and FIG. 2 is a system configuration diagram of one aspect of an oxygen saturation measurement system that implements these methods. is there.

このシステム１０は、肌の通常の画像を撮ることができると共に、偏光を用いて肌の内部反射光画像と表面反射光画像を形成することのできる画像形成手段１、画像形成手段１で取得した内部反射光画像から肌の酸素飽和度を算出する演算装置２、演算装置２が算出した肌の酸素飽和度を表示するディスプレイ３及びプリンタ４を備えている。   The system 10 is obtained by the image forming unit 1 and the image forming unit 1 that can take a normal image of the skin and can form an internal reflection light image and a surface reflection light image of the skin using polarized light. A calculation device 2 that calculates the oxygen saturation level of the skin from the internally reflected light image, a display 3 that displays the oxygen saturation level of the skin calculated by the calculation device 2, and a printer 4 are provided.

画像形成手段１としては、照影用光源、デジタルカメラ、光源とデジタルカメラの前面にそれぞれ着脱自在に設けられた偏光板を備えたものを使用することができ、よりコンパクトな構成としては、例えば、特開平６−３１３７０８号公報に記載の皮膚表面観察装置に偏光フィルターを取り付けたもの等を使用することができる。ここで光源としてはＬＥＤを使用してもよい。   As the image forming means 1, a light source for projection, a digital camera, and a light source and a front surface of the digital camera each provided with a polarizing plate provided detachably can be used. As a more compact configuration, for example, A device provided with a polarizing filter to the skin surface observation device described in JP-A-6-313708 can be used. Here, an LED may be used as the light source.

また、画像形成手段１を形成するデジタルカメラとしては、倍率２０〜２００倍、ピクセル数として一辺が２００〜２０００画素、撮影範囲を考慮したドット密度として２００〜１００００ＤＰＩを得られるものが好ましい。   The digital camera that forms the image forming unit 1 is preferably one that can obtain a magnification of 20 to 200 times, a pixel number of 200 to 2000 pixels on one side, and a dot density of 200 to 10000 DPI in consideration of the photographing range.

演算手段２としては、後述する画像処理機能を備えたパーソナルコンピュータを使用することができる。このパーソナルコンピュータに接続するディスプレイ３及びプリンタ４には、倍率２００倍程度までの通常の画像、内部反射光画像、ヘモグロビン成分画像、酸素飽和度の計測結果等を適宜切り替え、あるいは同時に表示できるようにする。また、メラニン成分画像を表示できるようにしてもよい。   As the calculation means 2, a personal computer having an image processing function described later can be used. On the display 3 and the printer 4 connected to the personal computer, a normal image up to a magnification of about 200 times, an internally reflected light image, a hemoglobin component image, a measurement result of oxygen saturation, and the like can be appropriately switched or simultaneously displayed. To do. Moreover, you may enable it to display a melanin component image.

このシステムを用いて美容アドバイザー、化粧品の開発研究者等が被験者の肌の酸素飽和度を評価する場合、まず、美容アドバイザー等は、被験者の素肌の内部反射光画像を取得する。内部反射光画像は、デジタルカメラの前面の偏光板を、光源の前面の偏光板に対して偏光方向が直交するように装着し、表面反射光成分を除去することにより形成することができる。   When a beauty advisor, a cosmetics development researcher, or the like uses this system to evaluate the oxygen saturation of a subject's skin, first, the beauty advisor or the like acquires an internal reflection image of the subject's bare skin. The internally reflected light image can be formed by mounting a polarizing plate on the front surface of the digital camera so that the polarization direction is orthogonal to the polarizing plate on the front surface of the light source, and removing the surface reflected light component.

次に、演算装置２により、内部反射光画像に対して独立成分分析を行い、内部反射光画像からヘモグロビン成分画像を抽出する。ここで、独立成分分析とは、皮膚の層構造を、メラニンを主な色素成分として含有する表皮層と、ヘモグロビンを主な色素成分として含有する真皮層と、その他の色素成分を含有する皮下組織との積層構造であるとモデル化し、各層から独立的に信号が発せられ、それらが混合したものが画像信号になっていると考え、画像信号から各層の信号を分離抽出する分析方法である。   Next, the calculation device 2 performs independent component analysis on the internally reflected light image, and extracts a hemoglobin component image from the internally reflected light image. Here, independent component analysis refers to the skin layer structure, the epidermal layer containing melanin as the main pigment component, the dermis layer containing hemoglobin as the main pigment component, and the subcutaneous tissue containing other pigment components. This is an analysis method that separates and extracts the signals of each layer from the image signal, considering that the signal is emitted independently from each layer and the mixture of them is an image signal.

より具体的には、画像信号のＲＧＢについて、−log(Ｒ)、−log(Ｇ)、−log(Ｂ)をそれぞれｘ軸、ｙ軸、ｚ軸に割当て、肌の平坦部分の肌色をそこに色空間マッピングすると図３（ａ）に示すように、ほぼ平面状に分布することから、肌色には２成分が寄与していることがわかる。この独立的な２成分の信号強度を、それぞれメラニン量あるいはヘモグロビン量に対応するものと考え、図３（ｂ）に示すように、肌色は、メラニンの成分ベクトル（-log(Ｂ)に近い方）とヘモグロビンの成分ベクトル（-log(Ｇ)に近い方）の合成ベクトルであると考える。そこで、個々の被験者の内部反射光画像の信号からヘモグロビン量を表す信号を抽出し、ヘモグロビン成分量の分布画像を出力する。但し、起伏や照明ムラのある場合には、あらかじめ取得した光源成分のベクトルの方向に沿って、メラニン、ヘモグロビン両ベクトルを含む平面上に射影して陰影成分を除去したヘモグロビン成分量を得る。   More specifically, for RGB of the image signal, -log (R), -log (G), and -log (B) are assigned to the x-axis, y-axis, and z-axis, respectively, and the skin color of the flat portion of the skin is there. When color space mapping is performed, as shown in FIG. 3 (a), it is distributed in a substantially flat shape, so that it can be seen that two components contribute to the skin color. This independent two-component signal intensity is considered to correspond to the amount of melanin or hemoglobin, respectively, and as shown in FIG. 3 (b), the skin color is closer to the component vector of melanin (-log (B)) ) And the hemoglobin component vector (the one closer to -log (G)). Therefore, a signal representing the hemoglobin amount is extracted from the signal of the internally reflected light image of each subject, and a distribution image of the hemoglobin component amount is output. However, when there is unevenness or uneven illumination, the amount of hemoglobin component is obtained by projecting onto a plane containing both melanin and hemoglobin vectors along the direction of the vector of the light source component acquired in advance to remove the shadow component.

このような解析処理と画像処理の詳細はVol. 16, No. 9/ September 1999/ J. Opt. Soc. Am. A 2169に記載されており、パーソナルコンピュータに、市販の画像解析ソフト（例えば、AdobePhotoshop）を搭載することにより行うことができる。   Details of such analysis processing and image processing are described in Vol. 16, No. 9 / September 1999 / J. Opt. Soc. Am. A 2169, and commercially available image analysis software (for example, This can be done by installing Adobe Photoshop).

図４は、ある被験者の頬部位の肌の通常の拡大画像（ａ）と、そのヘモグロビン成分画像（ｂ）である。本発明らの知見によれば、ヘモグロビン成分画像の全体の明るさ、即ちピクセル毎の濃度平均は、肌の全体的な血流の良否に影響され、血流が良く酸化型ヘモグロビン濃度が高いほど、濃度が薄くなる。また、ヘモグロビン成分画像の濃度ムラは、還元型ヘモグロビン濃度の高い鬱血状態を反映し、通常、濃度ムラの大きいほど、即ち、ピクセル毎の濃度の標準偏差が大きい程、還元型ヘモグロビン濃度が高い。   FIG. 4 shows a normal enlarged image (a) of the skin of a cheek site of a subject and a hemoglobin component image (b) thereof. According to the knowledge of the present invention, the overall brightness of the hemoglobin component image, that is, the density average for each pixel is influenced by the quality of the overall blood flow of the skin, and the better the blood flow, the higher the oxidized hemoglobin concentration. , The concentration becomes thinner. The density unevenness of the hemoglobin component image reflects a congested state having a high reduced hemoglobin concentration. Usually, the greater the density unevenness, that is, the greater the standard deviation of the density for each pixel, the higher the reduced hemoglobin concentration.

そこで、このシステムでは、抽出したヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出する。これらの算出も、上述の市販の画像解析ソフトにより行うことができる。   Therefore, in this system, the standard deviation or average value of the density for each pixel of the extracted hemoglobin component image is calculated. These calculations can also be performed by the above-described commercially available image analysis software.

ヘモグロビン成分画像から得られる標準偏差や平均値の経時的変化は、従来の分光測定装置を用いて計測された酸素飽和度の経時的変化と良好に対応する。したがって、当該被験者について、ヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値の変化を追跡することにより、肌の酸素飽和度の変化を容易に知ることができる。   The change over time in the standard deviation and the average value obtained from the hemoglobin component image corresponds well with the change over time in the oxygen saturation measured using a conventional spectroscopic measurement device. Therefore, the change of the oxygen saturation degree of the skin can be easily known by tracking the change of the standard deviation or the average value of the density for each pixel of the hemoglobin component image for the subject.

ヘモグロビン成分画像から算出される標準偏差や平均値を、従来の分光測定法により計測される酸素飽和度の数値と対応させ、ヘモグロビン成分画像から算出される標準偏差や平均値から酸素飽和度を計測できるようにするためには、予め、複数の肌について分光測定法により酸素飽和度を計測すると共に、ヘモグロビン成分画像からピクセル毎の濃度の標準偏差又は平均値を算出しておき、これらの関係式を回帰法により求め、演算装置２に記憶させておくことが好ましい。   The standard deviation or average value calculated from the hemoglobin component image corresponds to the oxygen saturation value measured by the conventional spectroscopic method, and the oxygen saturation is measured from the standard deviation or average value calculated from the hemoglobin component image. In order to be able to do this, oxygen saturation is measured in advance for a plurality of skins by spectroscopic measurement, and the standard deviation or average value of the concentration for each pixel is calculated from the hemoglobin component image, and these relational expressions are obtained. Is preferably obtained by a regression method and stored in the arithmetic unit 2.

この関係式としては、例えば、次式（１）をあげることができる。   As this relational expression, for example, the following expression (1) can be given.

Figure 2006271815
（式中、σ：ヘモグロビン成分画像のピクセル毎の濃度の標準偏差
Ａ：ヘモグロビン成分画像のピクセル毎の濃度の平均値
ａ、ｂ、ｃ、ｄ：係数 ）
Figure 2006271815
 (Where, σ: standard deviation of density for each pixel of the hemoglobin component image A: average value of density for each pixel of the hemoglobin component image a, b, c, d: coefficient)

また、演算装置２に、肌のヘモグロビン成分画像から算出したピクセル毎の濃度の標準偏差又は平均値と、その肌の分光測定装置による酸素飽和度とを多数蓄積してこれらのデータベースを構築し、このデータベースから上述の関係式（１）を算出するようにしてもよく、また、演算装置２とは別個の管理サーバー５にデータベースを構築し、この管理サーバー５に演算装置２が通信手段により適宜アクセスし、上述の関係式（１）を取得できるようにしてもよい。   In addition, in the arithmetic unit 2, a large number of standard deviations or average values of the concentrations for each pixel calculated from the hemoglobin component image of the skin and the oxygen saturation by the skin spectroscopic measurement device are accumulated to construct these databases. The above relational expression (1) may be calculated from this database, or a database is constructed in a management server 5 separate from the computing device 2, and the computing device 2 is appropriately connected to the management server 5 by communication means. You may make it possible to access and acquire the above-mentioned relational expression (1).

演算装置２は、関係式（１）を使用し、被験者のヘモグロビン成分画像から算出したピクセル毎の濃度の標準偏差又は平均値から、当該被験者の肌の酸素飽和度を計測する。   The arithmetic device 2 uses the relational expression (1) and measures the oxygen saturation of the subject's skin from the standard deviation or average value of the concentration for each pixel calculated from the subject's hemoglobin component image.

美容アドバイザーは、計測された被験者の肌の酸素飽和度を、一般的な望ましい酸素飽和度と対比し、必要に応じて、被験者に肌の血流改善方法等の美容アドバイスを行う。あるいはまた、被験者の酸素飽和度を経時的に計測した場合、その変化から、前回の美容アドバイスの効果を判断し、今後の美容アドバイスに活かすことができ、また、被験者には、美容アドバイスの効果を肌の酸素飽和度という数値データに基づいて説明することができる。さらに、これらの肌の酸素飽和度に関する美容アドバイスを、画像形成手段１で得られる通常の肌の拡大画像の観察結果と併せて行うことができる。   The beauty advisor compares the measured oxygen saturation of the subject's skin with a general desired oxygen saturation, and gives beauty advice such as a method for improving skin blood flow to the subject as necessary. Alternatively, if the oxygen saturation of the subject is measured over time, the effect of the previous beauty advice can be judged from the change, and it can be used for future beauty advice. Can be explained based on numerical data of oxygen saturation of the skin. Furthermore, the beauty advice regarding the oxygen saturation of the skin can be given together with the observation result of the normal enlarged image of the skin obtained by the image forming means 1.

以下、実施例に基づいて本発明を具体的に説明する。   Hereinafter, the present invention will be specifically described based on examples.

実施例１
日本人女性２０を被験者とし、その頬と腕の酸素飽和度を、図２のシステムにより計測した。 Example 1
A Japanese female 20 was a subject, and the oxygen saturation of the cheek and arm was measured by the system shown in FIG.

この場合、画像形成手段の倍率は、２０倍とし、撮影範囲１辺1ｃｍについて画素６４０×４８０の内部反射光画像を取得し、得られた内部反射光画像のピクセル毎の標準偏差と平均値とを算出した。   In this case, the magnification of the image forming unit is set to 20 times, and an internal reflected light image of the pixel 640 × 480 is acquired for 1 cm on one side of the photographing range, and the standard deviation and average value for each pixel of the obtained internal reflected light image are obtained. Was calculated.

一方、同じ被験者の測定部位について、特許文献２の手法により算出した肌の酸素飽和度（ＩＳ）を計測し、これと前述の標準偏差及び平均値から得られた式（１）（a=0.1, b=0.001, c=0.001, d=0.001）にて求めた値をプロットし、図５の相関図を得た。   On the other hand, the skin oxygen saturation (IS) calculated by the method of Patent Document 2 is measured for the measurement site of the same subject, and the equation (1) (a = 0.1) obtained from the standard deviation and average value described above is measured. , b = 0.001, c = 0.001, d = 0.001), and plotted to obtain the correlation diagram of FIG.

図５の結果から、本法の式（１）の酸素飽和度と、従来の分光測定装置により得られる酸素飽和度とには高い相関のあることがわかる。   From the result of FIG. 5, it can be seen that there is a high correlation between the oxygen saturation of the formula (1) of this method and the oxygen saturation obtained by the conventional spectroscopic measurement apparatus.

本発明は、化粧品の製品開発や、店頭等において顧客のうっ血状態を観察提示し、化粧品の血流改善効果及びそれに伴う酸素飽和度の改善状態を説明する場合等で有用となる。   INDUSTRIAL APPLICABILITY The present invention is useful when developing a cosmetic product, observing and presenting a customer's blood stasis state at a store, etc., and explaining the blood flow improvement effect of the cosmetic product and the accompanying oxygen saturation improvement state.

本発明の酸素飽和度計測方法のフローシートである。It is a flow sheet of the oxygen saturation measuring method of the present invention. 本発明のシステム構成図である。It is a system configuration diagram of the present invention. 独立成分分析の説明図である。It is explanatory drawing of independent component analysis. 通常の肌の拡大画像（ａ）と、そのヘモグロビン成分画像（ｂ）である。An enlarged image (a) of a normal skin and a hemoglobin component image (b) thereof. 従来の分光測定装置による肌の酸素飽和度（ＩＳ）と、肌のヘモグロビン成分画像のピクセル毎の濃度の標準偏差／平均値との関係図である。It is a related figure of the oxygen saturation (IS) of the skin by the conventional spectrometer, and the standard deviation / average value of the density | concentration for every pixel of the hemoglobin component image of skin.

符号の説明Explanation of symbols

１ 画像形成手段
２ 演算装置
３ ディスプレイ
４ プリンタ
５ 管理サーバー
１０ 酸素飽和度計測システム
DESCRIPTION OF SYMBOLS 1 Image formation means 2 Arithmetic apparatus 3 Display 4 Printer 5 Management server 10 Oxygen saturation measuring system

Claims (5)

被験者の肌の内部反射光画像を取得し、
該内部反射光画像から独立成分分析によりヘモグロビン成分画像を抽出し、
該ヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出し、
該標準偏差又は平均値を用いて肌の酸素飽和度を評価する酸素飽和度評価方法。 Acquire an internal reflection image of the subject's skin,
Extracting a hemoglobin component image from the internally reflected light image by independent component analysis,
Calculate the standard deviation or average value of the density for each pixel of the hemoglobin component image,
An oxygen saturation evaluation method for evaluating oxygen saturation of skin using the standard deviation or average value. 肌拡大画像撮影装置を用いて倍率２０〜２００倍の肌の内部反射光画像を取得する請求項１記載の評価方法。   The evaluation method according to claim 1, wherein an internal reflection light image of skin having a magnification of 20 to 200 times is acquired using a skin enlargement image photographing device. 複数の肌について、分光測定法により酸素飽和度を計測すると共に、
請求項１又は２記載の方法によりヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出し、
該標準偏差又は平均値と前記酸素飽和度との関係式を取得し、
任意の肌について、内部反射光画像から独立成分分析によりヘモグロビン成分画像を抽出し、
該ヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出し、
前記関係式を用いて該標準偏差又は平均値から当該任意の肌の酸素飽和度を算出する酸素飽和度計測方法。 For multiple skins, measure oxygen saturation by spectroscopic methods,
The standard deviation or average value of the density for each pixel of the hemoglobin component image is calculated by the method according to claim 1 or 2,
Obtain a relational expression between the standard deviation or average value and the oxygen saturation,
For any skin, extract the hemoglobin component image from the internal reflection image by independent component analysis,
Calculate the standard deviation or average value of the density for each pixel of the hemoglobin component image,
An oxygen saturation measurement method for calculating the oxygen saturation of the arbitrary skin from the standard deviation or average value using the relational expression. (i)肌の内部反射光画像を形成することのできる画像形成手段、
(ii)複数の肌について、ヘモグロビン成分画像から算出したピクセル毎の濃度の標準偏差又は平均値と、分光測定法による酸素飽和度との関係式を記憶する手段、
任意の肌について、内部反射光画像から独立成分分析によりヘモグロビン成分画像を抽出する手段、
該ヘモグロビン成分画像のピクセル毎の濃度の標準偏差又は平均値を算出する手段、及び
前記関係式を用いて該標準偏差又は平均値から当該任意の肌の酸素飽和度を算出する手段を備えた演算装置、
(iii)演算装置が算出した任意の肌の酸素飽和度を表示する表示手段
を備えた酸素飽和度計測システム。 (i) image forming means capable of forming an internally reflected light image of the skin,
(ii) means for storing a relational expression between a standard deviation or an average value of the concentration for each pixel calculated from a hemoglobin component image and oxygen saturation by a spectroscopic measurement method for a plurality of skins;
Means for extracting a hemoglobin component image from an internally reflected light image by independent component analysis for any skin;
Means for calculating a standard deviation or average value of the density of each pixel of the hemoglobin component image, and a means for calculating oxygen saturation of the arbitrary skin from the standard deviation or average value using the relational expression apparatus,
(iii) An oxygen saturation measuring system comprising display means for displaying the oxygen saturation of any skin calculated by the arithmetic device. 演算装置が、複数の肌について、ヘモグロビン成分画像から算出したピクセル毎の濃度の標準偏差又は平均値と、分光測定法による酸素飽和度とを対応させたデータベースを構築し、ヘモグロビン成分画像から算出したピクセル毎の濃度の標準偏差又は平均値と、分光測定法による酸素飽和度との関係式を算出する手段を有する請求項４記載の酸素飽和度計測システム。
The arithmetic unit constructed a database that correlates the standard deviation or average value of the concentration for each pixel calculated from the hemoglobin component image and the oxygen saturation by the spectroscopic measurement method for a plurality of skins, and calculated from the hemoglobin component image 5. The oxygen saturation measurement system according to claim 4, further comprising means for calculating a relational expression between a standard deviation or an average value of the concentration for each pixel and an oxygen saturation obtained by a spectroscopic measurement method.
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