JP2006257074A5 - - Google Patents

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Publication number
JP2006257074A5
JP2006257074A5 JP2006034041A JP2006034041A JP2006257074A5 JP 2006257074 A5 JP2006257074 A5 JP 2006257074A5 JP 2006034041 A JP2006034041 A JP 2006034041A JP 2006034041 A JP2006034041 A JP 2006034041A JP 2006257074 A5 JP2006257074 A5 JP 2006257074A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
cationic peptide
physiologically active
active protein
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JP2006034041A
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Japanese (ja)
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JP2006257074A (en
JP5103748B2 (en
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Priority to JP2006034041A priority Critical patent/JP5103748B2/en
Priority claimed from JP2006034041A external-priority patent/JP5103748B2/en
Publication of JP2006257074A publication Critical patent/JP2006257074A/en
Publication of JP2006257074A5 publication Critical patent/JP2006257074A5/ja
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Claims (9)

生理活性タンパク質を、活性を保持した状態で腸管内から血中に移行させる医薬組成物であって、成分として生理活性タンパク質およびカチオン性ペプチドを含有し、生理活性タンパク質とカチオン性ペプチドが共有結合で連結されていない医薬組成物。 The physiologically active protein, a pharmaceutical composition to migrate into the blood from the intestine while holding the activity, contains a bioactive protein and a cationic peptide as a component, a covalent bond bioactive protein and the cationic peptides A pharmaceutical composition not linked by カチオン性ペプチドと生理活性タンパク質の混合比が、モル比((カチオン性ペプチドのモル数)/(生理活性タンパク質のモル数))として3000以下である請求項1記載の医薬組成物。   The pharmaceutical composition according to claim 1, wherein the mixing ratio of the cationic peptide and the physiologically active protein is 3000 or less as a molar ratio ((number of moles of cationic peptide) / (number of moles of physiologically active protein)). カチオン性ペプチドが、アルギニンオリゴマーあるいはその誘導体である請求項1または2に記載の医薬組成物。   The pharmaceutical composition according to claim 1 or 2, wherein the cationic peptide is an arginine oligomer or a derivative thereof. カチオン性ペプチドが、D−アルギニンオリゴマーあるいはその誘導体である請求項1または2に記載の医薬組成物。   The pharmaceutical composition according to claim 1 or 2, wherein the cationic peptide is a D-arginine oligomer or a derivative thereof. カチオン性ペプチドが、5−15残基のD−アルギニンからなるオリゴマーである請求項1または2に記載の医薬組成物。   The pharmaceutical composition according to claim 1 or 2, wherein the cationic peptide is an oligomer composed of 5-15 residue D-arginine. カチオン性ペプチド化合物が、プロタミンあるいはその部分ペプチドあるいはその誘導体である請求項1または2に記載の医薬組成物。   The pharmaceutical composition according to claim 1 or 2, wherein the cationic peptide compound is protamine or a partial peptide thereof or a derivative thereof. 生理活性タンパク質の等電点が7以下である請求項1〜6のいずれかに記載の医薬組成物。   The pharmaceutical composition according to any one of claims 1 to 6, wherein the physiologically active protein has an isoelectric point of 7 or less. 生理活性タンパク質の分子量が、30000以下である請求項1〜7のいずれかに記載の医薬組成物。   The pharmaceutical composition according to any one of claims 1 to 7, wherein the molecular weight of the physiologically active protein is 30000 or less. 生理活性タンパク質が、インスリン、カルシトニン、副甲状腺ホルモン、成長ホルモン、インターフェロン類、インターロイキン類、およびG−CSFから選ばれる請求項1〜8のいずれかに記載の医薬組成物。   The pharmaceutical composition according to any one of claims 1 to 8, wherein the physiologically active protein is selected from insulin, calcitonin, parathyroid hormone, growth hormone, interferons, interleukins, and G-CSF.
JP2006034041A 2005-02-16 2006-02-10 Pharmaceutical composition Active JP5103748B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006034041A JP5103748B2 (en) 2005-02-16 2006-02-10 Pharmaceutical composition

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005038850 2005-02-16
JP2005038850 2005-02-16
JP2006034041A JP5103748B2 (en) 2005-02-16 2006-02-10 Pharmaceutical composition

Publications (3)

Publication Number Publication Date
JP2006257074A JP2006257074A (en) 2006-09-28
JP2006257074A5 true JP2006257074A5 (en) 2009-02-26
JP5103748B2 JP5103748B2 (en) 2012-12-19

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ID=37096715

Family Applications (1)

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JP2006034041A Active JP5103748B2 (en) 2005-02-16 2006-02-10 Pharmaceutical composition

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JP (1) JP5103748B2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101959532B (en) 2008-02-28 2013-02-27 东丽株式会社 Pharmaceutical composition for transnasal administration
WO2011005540A1 (en) 2009-06-22 2011-01-13 Burnham Institute For Medical Research Methods and compositions using peptides and proteins with c-terminal elements
HUP0900482A2 (en) * 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
WO2017183559A1 (en) * 2016-04-19 2017-10-26 学校法人神戸学院 Transmucosal absorption promoter for drug

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61115030A (en) * 1984-11-07 1986-06-02 Lion Corp Remedy for osteopathy
JP3770666B2 (en) * 1996-09-20 2006-04-26 株式会社ティ・ティ・エス技術研究所 Composition for transmucosal absorption preparation
SK262001A3 (en) * 1998-07-08 2001-09-11 Kirin Amgen Inc Powdery preparation for mucosal administration containing polymeric medicine
JP2000281589A (en) * 1999-03-26 2000-10-10 T T S Gijutsu Kenkyusho:Kk Transmucosal absorption adjuvant
AU2002354951A1 (en) * 2001-07-19 2003-03-03 Dmi Biosciences, Inc. Use of copper chelators to inhibit the inactivation of protein c

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