JP2006206514A - テトラヒドロイソキノリン化合物の製造方法 - Google Patents
テトラヒドロイソキノリン化合物の製造方法 Download PDFInfo
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- JP2006206514A JP2006206514A JP2005021619A JP2005021619A JP2006206514A JP 2006206514 A JP2006206514 A JP 2006206514A JP 2005021619 A JP2005021619 A JP 2005021619A JP 2005021619 A JP2005021619 A JP 2005021619A JP 2006206514 A JP2006206514 A JP 2006206514A
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- tetrahydroisoquinoline
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- TUCZQHRPSSVDQZ-UHFFFAOYSA-N CC(C1)N1C1(C)C=C1 Chemical compound CC(C1)N1C1(C)C=C1 TUCZQHRPSSVDQZ-UHFFFAOYSA-N 0.000 description 1
- 0 CC(CC1C2)C2C1=* Chemical compound CC(CC1C2)C2C1=* 0.000 description 1
- GHFGJTVYMNRGBY-UHFFFAOYSA-N NCCc1cccc(O)c1 Chemical compound NCCc1cccc(O)c1 GHFGJTVYMNRGBY-UHFFFAOYSA-N 0.000 description 1
- ZCNSVVDWODXGJM-UHFFFAOYSA-N Oc1ccc(C(c2ccccc2)NCC2)c2c1 Chemical compound Oc1ccc(C(c2ccccc2)NCC2)c2c1 ZCNSVVDWODXGJM-UHFFFAOYSA-N 0.000 description 1
- QYKMMCXVLIUYLY-UHFFFAOYSA-N Oc1cccc2c1C(c1ccccc1)NCC2 Chemical compound Oc1cccc2c1C(c1ccccc1)NCC2 QYKMMCXVLIUYLY-UHFFFAOYSA-N 0.000 description 1
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- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
【解決手段】 β−アリールエチルアミン化合物とアルデヒド化合物とを、触媒量のイッテルビウムトリフラートまたはインジウムトリフラートの存在下で反応させることを特徴とする、テトラヒドロイソキノリン化合物の製造方法。本方法によれば、医薬品等の中間原料として有用なテトラヒドロイソキノリン化合物を、高い反応収率と位置選択性を伴って、より簡便かつ安価に製造することができる。
【選択図】 なし
Description
Claims (2)
- β−アリールエチルアミン化合物とアルデヒド化合物とを、触媒量のイッテルビウムトリフラートまたはインジウムトリフラートの存在下で反応させることを特徴とする、テトラヒドロイソキノリン化合物の製造方法。
- 脱水剤の存在下で反応させる、請求項1に記載の製造方法。
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JP2005021619A JP4522874B2 (ja) | 2005-01-28 | 2005-01-28 | テトラヒドロイソキノリン化合物の製造方法 |
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JP2006206514A true JP2006206514A (ja) | 2006-08-10 |
JP4522874B2 JP4522874B2 (ja) | 2010-08-11 |
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