JP2006206480A - Aqueous composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a means enabling the effective utilization of iodine in solution containing an iodophor. <P>SOLUTION: This aqueous composition is provided by containing the iodophor, an iodine-based oxidizing agent and an aqueous medium, and showing <7.0 pH at 25°C. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an aqueous composition containing iodophor. More particularly, the present invention relates to improvements for effectively utilizing iodophor in aqueous compositions.

  It has been widely known that iodine is effective for sterilization, deodorization, antiseptic and the like. However, iodine is difficult to dissolve in water and easily volatilizes at room temperature. Furthermore, it is highly corrosive to metals and the like. For this reason, when using iodine for said use, for example, the usage method was limited.

  In order to compensate for such drawbacks, various iodine holes have been proposed for the purpose of improving iodine solubility and reducing volatility and corrosivity (see, for example, Patent Documents 1 to 4). As a specific example of iodophor, Patent Document 1 discloses a complex of chitosan and iodine as a carrier. Patent Documents 2 and 3 disclose a complex of polyvinylpyrrolidone (PVP), which is a carrier, and iodine (hereinafter also referred to as “povidone iodine”). Patent Document 4 discloses an iodine-cyclodextrin inclusion compound (hereinafter also referred to as “CDI”) in which an iodine atom is included in cyclodextrin.

According to these iodophor forms, the solubility of iodine in water can be improved. Moreover, since iodine is gradually released from these iodophors, the original bactericidal action and deodorizing action of iodine can be exhibited over a long period of time.
Japanese Patent Publication No. 60-19762 US Pat. No. 2,739,922 US Pat. No. 3,028,300 JP-A-51-88625

By the way, it is considered that iodine is contained in the form of triiodide ions (I ₃ ⁻ ) and pentaiodide ions (I ₅ ⁻ ) in the above iodophor.

Here, when the iodophor solution is stored for a long period of time, triiodide ions (I ₃ ⁻ ) and pentaiodide ions (I ₅ ⁻ ) are released little by little from iodophor during storage. And I ₃ ⁻ and I ₅ ⁻ are decomposed into iodine molecules (I ₂ ) and iodide ions (I ⁻ ). At this time, the iodide ion (I ⁻ ) remains in the solution in an ionic state, but the iodine molecule (I ₂ ) is poorly soluble in water, so that it crystallizes and precipitates, and in some cases it is outside the system. Or volatilize. As a result, the concentration of free iodine contained as iodophor in the solution may decrease, and the bactericidal action and deodorizing action may not be sufficiently exhibited.

In addition, when iodine contained in the form of ions (I ₃ ⁻ and I ₅ ⁻ ) in iodophor exerts a bactericidal action and a deodorizing action, microorganisms such as bacteria, fungi, protozoa and viruses, organic substances, etc. Is reduced by the reaction with I to produce I ⁻ , and similarly the iodide ion (I ⁻ ) concentration in the solution increases.

However, iodide ions (I ⁻ ) whose concentration in the solution has increased are rarely recaptured into carriers such as CDI to regenerate iodophor, and such solutions are used for sterilization and deodorization purposes. However, the activity of sterilization and deodorization disappears in a short time, and it is difficult to obtain a sufficient effect. On the other hand, when a high concentration of iodophor is added to the preparation in order to obtain a sufficient effect, there is a possibility that iodine color adheres to the object to be processed or corrosion of the object to be processed occurs. Therefore, the present situation is that development of a technique for effectively utilizing iodine contained in a solution containing iodophor is desired.

  Then, an object of this invention is to provide the means which enables the effective utilization of the iodine in the solution containing an iodophor.

  The present invention is an aqueous composition comprising iodophor, an iodine-based oxidizing agent, and an aqueous medium and having a pH at 25 ° C. of less than 7.0.

  The present invention also provides a solid composition comprising an iodophor carrier, an iodine raw material, an iodine-based oxidant raw material, and an acid.

According to the aqueous composition of the present invention, iodide ion (I ⁻ ) generated during storage or use of the composition is converted to I ₃ ⁻ or I ₅ ⁻ by the action of an iodine-based oxidizing agent, and is contained in the carrier. The iodine hole can be regenerated by being taken in. Therefore, effective use of iodine in the composition is achieved, and even if the initial free iodine concentration is low, the effects of sterilization and deodorization can be sufficiently exerted. Furthermore, since the concentration of free iodine dissolved in the initial composition can be reduced, the occurrence of problems such as iodine color adhesion to the object to be processed and corrosion of the object to be processed can be suppressed.

  Embodiments of the present invention will be described below.

  The first of the present invention is an aqueous composition comprising iodophor, an iodine-based oxidizing agent, and an aqueous medium and having a pH at 25 ° C. of less than 7.0.

The present inventors have made intensive studies, by the coexistence of iodine oxidizing agent in the aqueous composition comprising a iodophor, I in solution ^- the I ₃ ^- and I ₅ ^- is converted to by iodine It has been found that holes can be regenerated and effective utilization of iodine in the composition can be promoted. In particular, the inventors have found that iodine can be used very effectively in the composition by coexisting an iodine-based oxidizing agent in an aqueous composition containing CDI, and the present invention has been completed.

  Hereinafter, the constitution of the aqueous composition of the present invention will be described.

[Iodo Hall]
The aqueous composition of the present invention contains iodophor. In the present invention, “iodohol” means a preparation in which iodine is supported on a suitable carrier capable of supporting iodine atoms. In the composition of the present invention, since iodine is contained in the form of iodophor, there is a problem that the sustainability cannot be obtained due to volatilization of the contained iodine in a short time, and the iodine characteristic associated therewith Occurrence of a problem such as a bad odor can be prevented.

The specific form of the iodo hole is not particularly limited, and any form can be used. Examples of the carrier that can be used in iodophor include cyclodextrin (CD), PVP, glycine and the like. Newly developed carriers may be used. There is no particular limitation on the form of iodine atoms contained in iodohol, but iodine atoms are contained in iodophor in the form of triiodide ions (I ₃ ⁻ ) or pentaiodide ions (I ₅ ⁻ ). It is common.

  As a result of further investigations, the present inventors have used cyclodextrin as a carrier and contained iodine in the form of an iodine-cyclodextrin inclusion compound (hereinafter abbreviated as “CDI”), whereby the effect of the present composition can be obtained. Has been found to be further improved. That is, in the present composition, when iodine is contained in the form of CDI, the utilization factor of iodine is further increased. Therefore, hereinafter, the present invention will be described in detail by taking as an example the case where CDI is used as the iodo hole, but the technical scope of the present invention should be determined based on the description of the scope of claims. It is not limited only to the form. Moreover, the following description regarding the iodine as a component of CDI applies similarly not only when the iodine is contained in the present composition in the form of CDI but also in the form of other iodine holes.

  As described above, CDI is a compound having a structure in which iodine atoms in the form of triiodide ions and pentaiodide ions are included by cyclodextrin. CDI is easy to control the retention and release of iodine, and the action of sterilization and deodorization by iodine can be controlled by adjusting the blending ratio of iodine and cyclodextrin as necessary.

  In addition, iodine constituting CDI is an essential mineral in animals and has been used as a disinfectant and a mouthwash for a long time. Furthermore, among cyclodextrins, for example, unsubstituted cyclodextrins and maltosyl group-modified cyclodextrins are approved as food additives. In addition, these components are biodegradable, and iodine is ionized to form potassium salts and sodium salts, while the above cyclodextrin is decomposed into water, carbon dioxide and the like by microorganisms in the soil. For this reason, this composition has almost no load with respect to an environment, and has high safety | security.

  The iodine used for production of the present composition is not particularly limited, and a commercially available product may be used as it is. Further, iodine synthesized by a known method such as heating distillation of potassium iodide and potassium dichromate may be used.

The cyclodextrin used in the production of the present composition is not particularly limited, and a commercially available product may be used as it is. The cyclodextrin may be synthesized by itself by a known method such as causing amylase derived from Bacillus macerans to act on starch. In the present application, “cyclodextrin” means α-, β-, and γ composed of 6, 7, and 8 cyclic α- (1 → 4) linked D-glucopyranose units, respectively. -In addition to cyclodextrins, including, for example, alkylated (methylated, ethylated, propylated, isopropylated, butylated, etc.), monoacetylated, triacetylated, monochlorotriazinylated chemical modifications . Specific examples of commercial products of cyclodextrin include α-cyclodextrin marketed as CAVAMAX (registered trademark) W6 series, β-cyclodextrin marketed as CAVAMAX (registered trademark) W7 series, and CAVAMAX (registered trademark) W8 series. Γ-cyclodextrin, commercially available as CAVASOL (registered trademark) W7 M series, methyl-β-cyclodextrin, commercially available as CAVASOL (registered trademark) W7 HP series, hydroxypropyl-β-cyclodextrin, CAVASOL ( (Registered trademark) Triacetyl-β-cyclodextrin marketed as W7 TA, monochlorotriazinyl-β-cyclodextrin marketed as CAVASOL (registered trademark) W7 MCT, etc. All of which are manufactured by Wacker). Depending on the case, other cyclodextrins such as a maltosyl group-substituted cyclodextrin marketed as Dixie Pearl or Isoelite (manufactured by Yokohama International Bio Laboratory Co., Ltd.) may be used. In addition, only 1 type of these cyclodextrins may be used independently, and 2 or more types may be used together.

  The cyclodextrin constituting CDI can be appropriately selected in consideration of the use and availability. From the viewpoint of excellent stability in an aqueous composition, for example, CDI in which iodine is included in α-cyclodextrin, methyl-β-cyclodextrin, or maltosyl group-substituted cyclodextrin may be employed. However, it goes without saying that other cyclodextrins may be used.

  The method for producing CDI used in the present invention is not particularly limited, and a conventionally known method or a combination thereof can be appropriately employed. For example, methods described in JP-A-51-88625, JP-A-51-100892, etc .; iodine is adjusted by adjusting the amount of iodine and the amount of iodine dissolution aid (for example, potassium iodide) to a predetermined range. Examples include a method of dissolving and adding cyclodextrin thereto; or a method of adding cyclodextrin to the CDI obtained by these methods to bring the iodine amount to a value within a desired range.

  Among these CDI production methods, according to the method in which iodine and a dissolution aid (for example, potassium iodide) are adjusted to a predetermined range to dissolve iodine, and cyclodextrin is added thereto, cyclohexane to be added is added. By adjusting the amount of dextrin, the amount of iodine included in the cyclodextrin can be controlled.

  The “dissolution aid” refers to a compound that assists in dissolving iodine in a solution. Examples of solubilizers include halogen acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, and hydrofluoric acid, sodium iodide, potassium iodide, magnesium iodide, calcium iodide, barium iodide, iodine. Alkali metal or alkaline earth metal halides such as ammonium chloride, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, barium chloride, sodium bromide, potassium bromide, magnesium bromide, calcium bromide, barium bromide Illustrated.

The content of CDI in the present composition is not particularly limited, and can be appropriately adjusted in consideration of a desired free iodine concentration, a limit where brown color due to iodine is acceptable, and the like. Although there is no restriction | limiting in particular also about the free iodine density | concentration in this composition, When an example is given, Preferably it is 0.00001-1.0 mass% (0.1-10000 mass ppm), More preferably, it is 0.0001-0. 0.1 mass% (1 to 1000 mass ppm), more preferably 0.001 to 0.01 mass% (10 to 100 mass ppm). If the free iodine concentration in the aqueous composition is too low, the bactericidal action and the deodorizing action may not be sufficiently exhibited. In the present application, “free iodine” refers to iodine molecules (I ₂ ), triiodide ions (I ₃ ⁻ ), and pentaiodide ions (I ₅ ⁻ ) in an aqueous composition. Further, the free iodine concentration refers to the total concentration of free iodine, which is a value measured by a technique employed in the examples described later.

[Iodine-based oxidizing agent]
The aqueous composition of the present invention contains an iodine-based oxidizing agent. In the present application, “iodine-based oxidizing agent” means hypoiodite ion (IO ⁻ ), iodate ion (IO ₃ ⁻ ), and periodate ion (IO ₄ ⁻ ). The oxidizing agent oxidizes I ⁻ having an increased concentration in the solution and converts it to I ₃ ⁻ or I ₅ ⁻ . Describing this mechanism in detail, I ⁻ represents the following chemical reaction formulas (1) to (3) by the action of each oxidizing agent:

Accordingly, it is oxidized to iodine molecules (I ₂ ), and further, I ₃ ⁻ and I ₅ ⁻ are generated by reaction with I ⁻ in the composition. Thus generated were I ₃ ^- and I ₅ ^- may be clathrate by cyclodextrin again. That is, CDI can be reproduced. Note that the above mechanism is merely a guess, and the technical scope of the present invention is not affected at all even if the functions and effects of the present invention are obtained by mechanisms other than those described above.

There is no particular limitation on the content of the iodine-based oxidizing agent. As shown in the above chemical reaction formula (1) ~ (3), I - from I ₃ ^- and I ₅ ^- In is regeneration reaction, iodine oxidizing agent, by acting as a source of free iodine, Is consumed. Therefore, the content of iodine-based oxidizing agent can affect the persistence of the action of the composition. In the present invention, an excessive amount of iodine-based oxidizing agent or a salt thereof may be dissolved or dispersed in the composition as long as the iodine-based oxidizing agent or salt thereof may be contained so as to precipitate. Further, from the viewpoint of the effect of the present invention to sufficiently obtain, aqueous compositions of the present invention, iodine atom from other than iodine oxidizing agent in the composition is all I ^- assumed to be, the I ^- a all I ₃ ^- the gram equivalent of the oxidizing agent capable of oxidizing to is 100 gram equivalents, preferably 10 gram equivalents or more, more preferably 100 gram equivalents or more, more preferably from 500 grams or more equivalents of iodine oxidizing agent Containing. If the amount of the iodine-based oxidizing agent in the composition is too small, I ⁻ produced in the composition is not efficiently converted to I ₃ ⁻ or I ₅ ⁻ , and iodine in the composition may not be effectively used. is there. However, it goes without saying that an iodine-based oxidizing agent in an amount outside the above range may be contained.

[Aqueous medium]
The aqueous composition of the present invention comprises an aqueous medium. That is, the aqueous composition of the present invention has a configuration in which the above-mentioned iodophor and iodine-based oxidizing agent are dissolved or dispersed, preferably dissolved in the aqueous medium.

The above-mentioned iodophor has good solubility in water. Therefore, the main component of the aqueous medium is water (H ₂ O). However, the form in which the aqueous medium contains a solvent other than water is not excluded. For example, solvents other than water, such as lower alcohols such as methanol, ethanol, n-propanol, and iso-propanol, and non-hydrous polyhydric alcohols such as ethylene glycol, propylene glycol, and glycerin, do not impair the effects of the present invention. May be included. In other words, water is preferably 80% by mass or more, more preferably 90% by mass or more, and particularly preferably 100% by mass with respect to the total amount of the aqueous medium. However, depending on the case, an aqueous medium outside the above range may be employed, and a solvent other than the above may be included in the aqueous medium.

  As can be seen from the chemical reaction formulas (1) to (3), the aqueous composition of the present invention is acidic. The specific value of the pH of the aqueous composition of the present invention is not particularly limited as long as the pH at 25 ° C. is less than 7.0. However, the pH of the aqueous composition of the present invention is preferably less than 4.0, more preferably less than 3.5 from the viewpoint of improving the function as a bactericidal and deodorizing action and an iodination reaction agent. . From the above viewpoint, the lower limit of the pH of the aqueous composition is not particularly limited, but considering the case where it is used for applications that can come into contact with the human body, the pH of the aqueous composition is preferably 2.0 or more, more Preferably it is 3.0 or more.

  The aqueous composition of this invention may contain components other than said component as needed.

  For example, the aqueous composition of the present invention is a fragrance (for example, l-menthol, phenethyl alcohol, caproic acid ethyl ester, etc.), antiseptic, antifungal agent, fungicide, acaricide, deodorant, essential oil, dye, It may contain pigments, pH buffering agents and the like. Depending on the case, one or more of iodophor carriers (eg, cyclodextrin) on which iodine is not supported may be added. Such a carrier can be utilized for the iodophor regeneration cycle in the present compositions. Among them, cyclodextrin alone can exert a deodorizing effect. In addition, the specific form of these other components is not restrict | limited at all, It is possible to select suitably by referring a conventionally well-known knowledge.

As mentioned above, although the structure of the aqueous composition of this invention was demonstrated, according to the aqueous composition of this invention, even if the density | concentration of I < ^- > ion increases in a composition at the time of long-term storage, said chemical reaction formula ( I ⁻ is converted to I ₃ ⁻ or I ₅ ⁻ by the action of the iodine-based oxidizing agent shown in 1) to (3), and is again included in cyclodextrin, so that CDI can be regenerated. That is, iodine and cyclodextrin contained in the composition at the time of manufacture can be reused. Therefore, according to this invention, more free iodine than the free iodine in the composition at the time of manufacture can exhibit effects, such as disinfection and deodorization. In other words, this is the same as maintaining the stability of free iodine in the composition over a longer period than before.

  In addition, according to the present invention, since CDI-derived iodine and cyclodextrin can be reused, the amount of CDI used at the time of production can be reduced as compared with the prior art. As a result, the manufacturing cost can be reduced, which can contribute to the improvement of market competitiveness of disinfectant and deodorant products. Furthermore, since the usage amount of CDI containing iodine can be reduced, the color tone and corrosiveness peculiar to iodine, which have been regarded as problems in the past, can be alleviated, and applicable applications can be expanded.

Further, for example, consider the case where the present composition is applied, dripped, sprayed, or the like in order to sterilize and deodorize a section to which contaminants including microorganisms are attached. When the contaminated portion is microscopically observed, the contaminant and the present composition come into contact with each other, and I ₃ ⁻ and I ₅ ⁻ in CDI exhibit a bactericidal action against microorganisms in the contaminant, such as microorganisms and organic matter. Reduction by means of I ⁻ produces. The present compositions, which are applied to the contaminated portion from being included iodine oxidizing agent, the above I ^- also react with the iodine oxidizer, I ₃ in the contaminants in ^- and I ₅ ^- to play . Since I ₃ ⁻ and I ₅ ⁻ thus regenerated can exert a bactericidal action again, the bactericidal action of the present composition can be sustained over a long period of time. In some cases, I ₃ ⁻ regenerated in the contaminants may be included again in cyclodextrin to regenerate CDI.

  The aqueous composition of the present invention can be used for various applications in which iodine can exert its action. Although the specific use is not particularly limited, it can be used for sterilization of bacteria and viruses, as well as for deodorization. Further, as will be apparent from Examples described later, in the aqueous composition of the present invention, the free iodine concentration can be maintained at a high value even under high temperature conditions exceeding 100 ° C. For this reason, it can be used for a preparation to be provided after being heat-sterilized by an autoclave or a preparation to be used after being heat-sterilized at the time of use. An example of such a use is a use as a bactericidal agent for a readily infectious host (patient) in a serious immunosuppressed state.

  The aqueous composition of the present invention can be produced without using a special technique. As an example of the production method, first, crystalline or powdered iodophor (for example, CDI) and iodine-based oxidant raw material (for example, a salt such as potassium iodate) are mixed with a predetermined dissolution aid (see above, For example, it is dissolved in water containing potassium iodide. Alternatively, a predetermined amount of cyclodextrin is added to water in which an iodine compound (for example, potassium iodide) serving as a dissolution aid and an iodine raw material and an iodine-based oxidizing agent raw material (for example, a salt such as potassium iodate) are dissolved. By doing so, you may manufacture this composition, producing | generating CDI. Such a production method is preferable because the free iodine concentration in the composition can be controlled by adjusting the addition amount of the iodine compound and cyclodextrin.

As the iodine material, iodine atom iodide ion (I ^-) metal salts containing in the form of (for example, potassium iodide (KI), and sodium iodide (NaI)) can be mentioned. This iodine raw material can be supported on an iodophor carrier (eg, cyclodextrin) in an aqueous medium to produce iodophor (eg, CDI). And the content of the iodine hole in the composition manufactured can be controlled by adjusting the addition amount of this iodine raw material. In some cases, simple iodine molecules (I ₂ ) may be used as an iodine raw material.

As the iodine oxidizer material is not particularly limited, for example, hypoiodous acid (HIO), iodate _(HIO 3), para periodate _(HIO 4), periodic acid _(H 5 _IO 6) Iodic acids such as, metal salts of the iodic acids (for example, sodium salts, potassium salts, etc.), iodine salts such as I (IO ₃ ) ₃ , iodic acid (I ₂ O), iodine trioxide (I ₂ Examples thereof include iodine oxides such as O ₃ ), iodine pentoxide (I ₂ O ₅ ), iodine heptoxide (I ₂ O ₇ ), and iodine tetroxide (IO ₄ ). This iodine-based oxidizing agent raw material can generate ions that are iodine-based oxidizing agents in an aqueous composition. And the content of the iodine type oxidant in the composition manufactured can be controlled by adjusting the addition amount of this iodine type oxidant raw material.

  Moreover, what is necessary is just to add an acid, in order to make pH of a composition into a desired value at the time of manufacture of this composition. Thereby, this composition may be manufactured. However, the acid may be added before, after, or simultaneously with the addition of the above components. The specific kind and amount of the acid used for pH adjustment are not particularly limited, and can be appropriately selected. For example, inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, carbonic acid, and phosphoric acid, and organic acids such as citric acid, acetic acid, malic acid, succinic acid, oxalic acid, butyric acid, and lactic acid may be added. In some cases, organic acids other than carboxylic acids such as sulfonic acid, sulfinic acid, selenonic acid, phenol and derivatives thereof may be used. In addition, when this composition is used, for example as a disinfectant, it is good to adjust pH of a composition using said organic acid. According to such a form, the efficacy as a disinfectant of the present composition can be improved.

  The present application also provides a solid composition from which the aqueous composition of the present invention can be prepared. That is, the second of the present invention is a solid composition containing an iodophor carrier, an iodine raw material, an iodine-based oxidizing agent raw material, and an acid. When such a solid composition is added to an aqueous medium, the first aqueous composition of the present invention can be easily produced.

  Since the specific form of each component constituting the solid composition is as described in the above-mentioned column of the method for producing the first aqueous composition of the present invention, the description thereof is omitted here. However, as the acid, a solid acid such as citric acid monohydrate, succinic acid, malic acid, oxalic acid, tartaric acid, or a derivative thereof (for example, a hydrate) can be used. Further, the content of each component in the solid composition is not particularly limited, and can be appropriately adjusted in consideration of the desired content of each component in the aqueous composition produced by addition to the aqueous medium. . Furthermore, the second solid composition of the present invention may contain an additive that can be added to the first aqueous composition of the present invention or a raw material thereof.

  Although it does not restrict | limit especially about the specific form of the solid composition of this invention, From a viewpoint of the workability | operativity at the time of adding to an aqueous medium and manufacturing the 1st aqueous composition of this invention, and the ease of melt | dissolution, The solid composition of the present invention is preferably a powdered composition. However, it goes without saying that solid compositions of other forms may be used. Moreover, there is no restriction | limiting in particular also about the particle size of each component in a powdery composition, A conventionally well-known knowledge can be referred suitably in the manufacture field | area of a composition like this invention.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, the technical scope of this invention is not restrict | limited only to the following forms.

<Example 1>
In water, α-cyclodextrin (0.3 g / 100 mL water), methyl-β-cyclodextrin (0.7 g / 100 mL water), citric acid monohydrate (0.2 g / 100 mL water), potassium iodate ( 0.1 g / 100 mL water) and potassium iodide (2.7 mg / 100 mL water) were added and stirred to prepare an aqueous composition (pH: 2.5) of the present invention. The amount of each component added is shown in Table 1 below. In addition, it was 25 ppm when the free iodine density | concentration in the obtained aqueous composition was measured. Further, iodine-based oxidizing agent in the composition (IO from potassium iodate 3 ^_-) iodine atom from other than all I ^- assumed to be, the I ^- all I ₃ ^- was oxidized to be oxidized When the gram equivalent of the agent was 100 gram equivalent, the content of the iodine-based oxidizing agent (IO ₃ ⁻ ) in the composition was 1300 gram equivalent.

<Example 2>
An aqueous composition (pH: 2.5) of the present invention was prepared in the same manner as in Example 1 except that the amount of potassium iodide added was (5.5 mg). The amount of each component added is shown in Table 1 below. In addition, it was 50 ppm when the free iodine density | concentration in the obtained aqueous composition was measured. Moreover, content of the iodine type oxidizing agent (IO < ₃ > ^- ) by the definition similar to the above was 650 gram equivalent.

<Comparative example>
Instead of adding potassium iodate and potassium iodide, instead of these, an iodine-cyclodextrin inclusion compound (MCDI-6, manufactured by Niho Chemical Co., Ltd.), in which iodine is included in methyl-β-cyclodextrin, An aqueous composition (pH: 2.5) was prepared in the same manner as in Example 1 except that 86 mg / 100 mL water was added (free iodine concentration: 6% by mass). The amount of each component added is shown in Table 1 below. In addition, it was 50 ppm when the free iodine density | concentration in the obtained aqueous composition was measured.

<Antimicrobial test>
The antibacterial properties of the aqueous compositions prepared in Example 1 and Comparative Example were tested by the following method.

  First, S. aureus IFM2014 strain was inoculated into 10 mL of an aqueous solution of 37 g / L Brain Heart Infusion (hereinafter also simply referred to as “BHI”), and cultured with shaking at 37 ° C. for 20 hours. Was prepared.

  Subsequently, the aqueous composition prepared in Example 1 was prepared, and the aqueous composition prepared in Comparative Example was further diluted so that the free iodine concentration was 25 ppm. 10 mL each of these aqueous compositions (Example 1) or diluted aqueous compositions (Comparative Examples) were added to 15 test tubes. Each 15 test tube containing the composition of each example or comparative example was then charged with different amounts of BHI (5, 10, 20, 30, 40, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500 mg) were added and sterilized in an autoclave (121 ° C., 20 minutes).

After cooling the test tube, the test bacteria culture solution prepared above was added to each test tube so that the viable cell concentration after the addition was 1.0 × 10 ⁶ CFU / mL. Thereafter, each test tube was cultured with shaking at 37 ° C. for 20 hours, and the number of viable bacteria was measured by a pour culture method using a standard agar medium. The result is shown in FIG. In FIG. 1, the horizontal axis indicates the BHI concentration, and the vertical axis indicates the viable cell concentration.

As can be seen from FIG. 1, in the sample to which the aqueous composition of the comparative example was added, the presence of the test bacteria was confirmed at a BHI concentration of 4 g / L or more, and as the BHI concentration increased, The fungus concentration increased. For example, at a BHI concentration of 40 g / L, the viable cell concentration exceeds 1.16 × 10 ⁷ CFU / mL and the initial viable cell concentration (1.0 × 10 ⁶ CFU / mL), and the antibacterial activity of the composition It was suggested that was lost.

  In contrast, in the sample to which the aqueous composition of Example 1 was added, the presence of the test bacteria was not confirmed even at a BHI concentration of 50 g / L.

  Thus, in the aqueous composition of the present invention, even when there is an organic substance (such as bacteria) in an amount that cannot maintain antibacterial activity in the conventional iodophor-containing preparation, free iodine is produced by the action of the iodine-based oxidizing agent. It can be seen that the antibacterial activity can be maintained due to the regeneration.

<Stability test>
The stability of the aqueous compositions prepared in Example 2 and Comparative Example above was tested by the following procedure.

  First, the aqueous composition prepared in the above Example 2 was prepared, and the aqueous composition prepared in the above Comparative Example was further diluted so that the free iodine concentration was 50 ppm. 100 mL of each of these aqueous compositions (Example 2) or aqueous composition dilutions (Comparative Examples) was added into three triangular Kolbens, and each of the three triangular triangles for each of the Examples and Comparative Examples. Kolben was heat-treated at 121 ° C. by autoclaving for 20 minutes, 90 minutes, and 180 minutes, respectively.

  After the triangular Kolben was quenched with ice water, the absorbance at 438 nm of each sample was measured using an ultraviolet-visible photometer (Shimadzu UV-2500PC), the residual free iodine concentration was measured, and the initial free iodine concentration (50 ppm) was measured. Relative values were calculated. The result is shown in FIG. In FIG. 2, the horizontal axis indicates the heat treatment time, and the vertical axis indicates the relative value of the residual free iodine concentration with respect to the initial free iodine concentration.

  As can be seen from FIG. 2, in the aqueous composition of the comparative example, the free iodine concentration decreased to the initial 22% even by the heat treatment for 20 minutes, and the free iodine concentration became almost zero by the heat treatment for 180 minutes. .

  On the other hand, in the aqueous composition of Example 2, the free iodine concentration was as high as 89% even after the heat treatment for 180 minutes. From this, it is shown that the aqueous composition of the present invention is excellent in stability as compared with the conventional iodophor aqueous solution.

  In addition, according to the aqueous composition of this invention, a free iodine density | concentration can be maintained at a high value also by the high temperature process of 121 degreeC. This result shows that the composition of the present invention can be heat-sterilized at the time of use or provided as a preparation after being heat-sterilized depending on the use.

The results shown in the above Examples and Comparative Examples show that the aqueous composition of the present invention can maintain the free iodine concentration at a high value even after exhibiting antibacterial activity, or after storage or heat treatment. It is. As described above, this is because, as described above, I ⁻ in the composition increased with the exhibition of antibacterial activity and the passage of storage time, to I ₃ ⁻ and I ₅ ⁻ by the action of the iodine-based oxidizing agent in the composition. It is thought to be due to the oxidation of iodine holes by oxidation.

  That is, according to the aqueous composition of the present invention, iodine can be effectively used, and a substantially high iodine concentration can be maintained over a long period of time even with a small amount of iodine.

It is a graph which shows the result of the antimicrobial test in an Example. It is a graph which shows the result of the stability test in an Example.

Claims (7)

  An aqueous composition comprising iodophor, an iodine-based oxidizing agent, and an aqueous medium and having a pH of less than 7.0 at 25 ° C.   The aqueous composition according to claim 1, wherein the iodophor is an iodine-cyclodextrin inclusion compound in which iodine atoms are included in cyclodextrin.   The aqueous composition according to claim 2, wherein the cyclodextrin is α-cyclodextrin, methyl-β-cyclodextrin, or maltosyl-substituted cyclodextrin.   The aqueous composition of any one of Claims 1-3 whose free iodine density | concentration in a composition is 0.00001-1.0 mass% with respect to the whole quantity of a composition. Assuming that all iodine atoms derived from other than the iodine-based oxidant in the composition are I ⁻ , and the gram equivalent of the oxidant capable of oxidizing all of this I ⁻ to I ₃ ⁻ is 100 gram equivalent. The aqueous composition according to any one of claims 1 to 4, comprising 10 gram equivalents or more of an iodine-based oxidizing agent.   The aqueous composition according to claim 1, wherein the aqueous composition is used as a disinfectant or a deodorant.   A solid composition comprising an iodophor carrier, an iodine raw material, an iodine-based oxidant raw material, and an acid.

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