JP2006182755A5 - - Google Patents
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- Publication number
- JP2006182755A5 JP2006182755A5 JP2005170052A JP2005170052A JP2006182755A5 JP 2006182755 A5 JP2006182755 A5 JP 2006182755A5 JP 2005170052 A JP2005170052 A JP 2005170052A JP 2005170052 A JP2005170052 A JP 2005170052A JP 2006182755 A5 JP2006182755 A5 JP 2006182755A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- group
- use according
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 125000005843 halogen group Chemical group 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 150000002431 hydrogen Chemical class 0.000 claims 15
- -1 cyano, hydroxy Chemical group 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 10
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 125000003386 piperidinyl group Chemical group 0.000 claims 6
- QUIJNHUBAXPXFS-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C2=CC=CC=C2C=CC=1)C1=CC=CC=C1 QUIJNHUBAXPXFS-UHFFFAOYSA-N 0.000 claims 5
- 150000001204 N-oxides Chemical class 0.000 claims 5
- 125000002883 imidazolyl group Chemical group 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 125000002757 morpholinyl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004193 piperazinyl group Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 4
- 125000001425 triazolyl group Chemical group 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 3
- QUIJNHUBAXPXFS-XLJNKUFUSA-N bedaquiline Chemical compound C1([C@H](C2=CC3=CC(Br)=CC=C3N=C2OC)[C@@](O)(CCN(C)C)C=2C3=CC=CC=C3C=CC=2)=CC=CC=C1 QUIJNHUBAXPXFS-XLJNKUFUSA-N 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- XDEHPNQRQKHQQC-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,3-difluorophenyl)-4-(dimethylamino)-1-phenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C(=C(F)C=CC=1)F)C1=CC=CC=C1 XDEHPNQRQKHQQC-UHFFFAOYSA-N 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 2
- CLLPSOGUEAXIIW-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,5-difluorophenyl)-4-(dimethylamino)-1-phenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C(=CC=C(F)C=1)F)C1=CC=CC=C1 CLLPSOGUEAXIIW-UHFFFAOYSA-N 0.000 claims 1
- UAUNEMZTBIFYAG-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-2-(3,5-difluorophenyl)-4-(dimethylamino)-1-phenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C=C(F)C=C(F)C=1)C1=CC=CC=C1 UAUNEMZTBIFYAG-UHFFFAOYSA-N 0.000 claims 1
- VPZIAIQZWHQVKN-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-1,2-diphenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 VPZIAIQZWHQVKN-UHFFFAOYSA-N 0.000 claims 1
- CFPPFXNAPDMERR-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-1-(4-methylphenyl)-2-naphthalen-1-ylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C2=CC=CC=C2C=CC=1)C1=CC=C(C)C=C1 CFPPFXNAPDMERR-UHFFFAOYSA-N 0.000 claims 1
- HGUAWYGZOVFIAB-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(2-fluorophenyl)-1-phenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C(=CC=CC=1)F)C1=CC=CC=C1 HGUAWYGZOVFIAB-UHFFFAOYSA-N 0.000 claims 1
- TZNZMTAIOJDNJP-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(3-fluorophenyl)-1-phenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C=C(F)C=CC=1)C1=CC=CC=C1 TZNZMTAIOJDNJP-UHFFFAOYSA-N 0.000 claims 1
- GOBOQBZOZDRXCQ-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol Chemical compound C=1C=CC2=CC=CC=C2C=1C(O)(CCNC)C(C=1C(=NC2=CC=C(Br)C=C2C=1)OC)C1=CC=CC=C1 GOBOQBZOZDRXCQ-UHFFFAOYSA-N 0.000 claims 1
- PDQRQJVPEFGVRK-UHFFFAOYSA-N 2,1,3-benzothiadiazole Chemical compound C1=CC=CC2=NSN=C21 PDQRQJVPEFGVRK-UHFFFAOYSA-N 0.000 claims 1
- 125000004364 3-pyrrolinyl group Chemical group [H]C1=C([H])C([H])([H])N(*)C1([H])[H] 0.000 claims 1
- KBTKKEMYFUMFSJ-UHFFFAOYSA-N 6-bromo-2-methoxyquinoline Chemical compound C1=C(Br)C=CC2=NC(OC)=CC=C21 KBTKKEMYFUMFSJ-UHFFFAOYSA-N 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004604 benzisothiazolyl group Chemical group S1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
- 0 CCC(*C)(C(c1ccccc1)c1c(*)c(cccc2)c2nc1*)O Chemical compound CCC(*C)(C(c1ccccc1)c1c(*)c(cccc2)c2nc1*)O 0.000 description 3
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04078529 | 2004-12-24 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012248469A Division JP2013049704A (ja) | 2004-12-24 | 2012-11-12 | 潜伏性結核の処置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006182755A JP2006182755A (ja) | 2006-07-13 |
JP2006182755A5 true JP2006182755A5 (ru) | 2008-07-24 |
Family
ID=36736133
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005170052A Withdrawn JP2006182755A (ja) | 2004-12-24 | 2005-06-09 | 潜伏性結核の処置 |
JP2012248469A Withdrawn JP2013049704A (ja) | 2004-12-24 | 2012-11-12 | 潜伏性結核の処置 |
JP2015094241A Active JP6426530B2 (ja) | 2004-12-24 | 2015-05-01 | 潜伏性結核の処置 |
JP2017055989A Pending JP2017141259A (ja) | 2004-12-24 | 2017-03-22 | 潜伏性結核の処置 |
JP2017056728A Pending JP2017141262A (ja) | 2004-12-24 | 2017-03-22 | 潜伏性結核の処置 |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012248469A Withdrawn JP2013049704A (ja) | 2004-12-24 | 2012-11-12 | 潜伏性結核の処置 |
JP2015094241A Active JP6426530B2 (ja) | 2004-12-24 | 2015-05-01 | 潜伏性結核の処置 |
JP2017055989A Pending JP2017141259A (ja) | 2004-12-24 | 2017-03-22 | 潜伏性結核の処置 |
JP2017056728A Pending JP2017141262A (ja) | 2004-12-24 | 2017-03-22 | 潜伏性結核の処置 |
Country Status (9)
Country | Link |
---|---|
JP (5) | JP2006182755A (ru) |
KR (2) | KR101301573B1 (ru) |
CN (1) | CN101087608A (ru) |
BG (1) | BG66437B1 (ru) |
EA (1) | EA009779B1 (ru) |
ES (1) | ES2362886T3 (ru) |
JO (1) | JO2695B1 (ru) |
UA (1) | UA88766C2 (ru) |
ZA (1) | ZA200705160B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA97813C2 (ru) * | 2006-12-05 | 2012-03-26 | Янссен Фармацевтика Н.В. | Фумаратная соль (альфа s, бета r)-6-бром-альфа-[2-(диметиламино)этил]-2-метокси-альфа-1-нафталенил-бета-фенил-3-хинолинэтанола |
CN103664877A (zh) * | 2013-12-25 | 2014-03-26 | 重庆医药工业研究院有限责任公司 | 一种喹啉衍生物、其制备方法和应用 |
JP6997095B2 (ja) * | 2016-03-07 | 2022-02-03 | ザ グローバル アライアンス フォー ティービー ドラッグ デベロップメント, インコーポレイテッド | 抗菌性化合物およびその使用 |
CN109384716B (zh) * | 2017-08-11 | 2021-06-29 | 海创药业股份有限公司 | 一种氘代喹啉化合物及其制备和用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6075024A (en) * | 1991-11-27 | 2000-06-13 | Sepracor Inc. | Methods for treating infection using optically pure (S)-lomefloxacin |
PT1527050E (pt) * | 2002-07-25 | 2010-06-22 | Janssen Pharmaceutica Nv | Derivados de quinolina e sua utilização como inibidores de micobactérias |
NZ550840A (en) * | 2004-05-28 | 2010-01-29 | Janssen Pharmaceutica Nv | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases |
-
2005
- 2005-06-09 BG BG109180A patent/BG66437B1/bg unknown
- 2005-06-09 JP JP2005170052A patent/JP2006182755A/ja not_active Withdrawn
- 2005-06-09 EA EA200500802A patent/EA009779B1/ru unknown
- 2005-06-09 KR KR1020050049439A patent/KR101301573B1/ko active IP Right Grant
- 2005-12-06 JO JO2005194A patent/JO2695B1/en active
- 2005-12-08 ES ES05815816T patent/ES2362886T3/es active Active
- 2005-12-08 CN CNA2005800447974A patent/CN101087608A/zh active Pending
- 2005-12-09 UA UAA200511766A patent/UA88766C2/ru unknown
-
2007
- 2007-06-22 ZA ZA200705160A patent/ZA200705160B/xx unknown
-
2012
- 2012-11-12 JP JP2012248469A patent/JP2013049704A/ja not_active Withdrawn
-
2013
- 2013-03-29 KR KR1020130034387A patent/KR20130041872A/ko not_active Application Discontinuation
-
2015
- 2015-05-01 JP JP2015094241A patent/JP6426530B2/ja active Active
-
2017
- 2017-03-22 JP JP2017055989A patent/JP2017141259A/ja active Pending
- 2017-03-22 JP JP2017056728A patent/JP2017141262A/ja active Pending
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