JP2006181368A - Sterilization method of medical sterilization packing - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sterilization method of a medical sterilization packing which enables the efficient processing and can certainly prevent the hydrogen peroxide gas from remaining behind. <P>SOLUTION: The sterilization method is to execute the sterilization processing of a syringe containing a medicine as a medical product enclosed in a packaging container with the hydrogen peroxide gas as it remains packed. A container comprised of a main body of the container which has a gas barrier property, has a totally open bottom and is integrally formed from synthetic resin, and the sterilization paper as a covering material which allows the hydrogen peroxide gas to penetrate and can be deposited on the whole bottom of the main body of the container is used as the packaging container. Also, after the syringe containing the medicine is stored in a chamber which is a sterilization apparatus and the sterilization processing is executed by repeating the operation of supplying the hydrogen peroxide gas into the chamber with the reduced pressure of 10-30 torr for two or more times, the degassing processing of the hydrogen peroxide gas from the inside of the packaging container is executed while heating is executed. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a sterilization method in medical sterilization packaging, and more particularly, to a sterilization method in which a medical product enclosed in a packaging container, for example, a medicine-filled syringe, is sterilized with hydrogen peroxide gas in the package. In addition, the present invention relates to a sterilization method that can be efficiently processed and can reliably prevent the residual hydrogen peroxide gas.

  As with other disposable medical devices, the medicine-filled syringes are preferably distributed with medical sterilization packaging. Medical sterilization packaging uses a packaging container composed of a synthetic resin container body having gas barrier properties and sterilized paper as a lid material that is permeable to sterilization gas and can be welded to the container body. This is a packaging in a form in which the inside is sterilized with a sterilizing gas permeated with sterilized paper by exposing it to a sterilizing gas in a packaged state after enclosing the product.

In the above-mentioned medical sterilization packaging, the use of hydrogen peroxide gas instead of ethylene oxide has been studied for various medical products due to the toxicity of sterilization gas. In any case, post-treatment for removing the sterilization gas from the inside of the packaging container is indispensable in order to eliminate the harmfulness of the residual gas to the human body in the distribution process. Techniques relating to sterilization and sterilization using hydrogen peroxide are disclosed in the following publications and the like.
Japanese Patent Publication No.61-4543 Japanese Patent Laid-Open No. 1-121057

  By the way, in medical sterilization packaging, in order to completely remove the sterilization gas from the packaging container after the sterilization treatment, it is necessary to leave it for a considerably long time, and such a removal operation causes a reduction in manufacturing efficiency. In addition, when a polyester resin container is used, the sterilization gas adsorbability is high and it becomes difficult to remove the sterilization gas. Therefore, in reality, many containers mainly composed of vinyl chloride are used. Yes. As a result, the visibility of the inside of the packaging container is poor, and there is also a problem that chlorine gas is generated when vinyl chloride is disposed of.

  The present invention has been made in view of the above circumstances, and an object of the present invention is, for example, a sterilization method of sterilizing a medicine-filled syringe or the like with a hydrogen peroxide gas in a package, which can be efficiently processed and excessively processed. It is an object of the present invention to provide a sterilization method in medical sterilization packaging that can reliably prevent hydrogen oxide gas from remaining and can be applied to a packaging material of polyester resin.

  In order to solve the above problems, the sterilization method in the medical sterilization packaging according to the present invention is a sterilization method in which a medicine-filled syringe as a medical product enclosed in a packaging container is sterilized with hydrogen peroxide gas. As a container, an integrally molded container body made of a synthetic resin that has gas barrier properties and the entire bottom surface is opened, and a lid material that can transmit hydrogen peroxide gas and can be welded to the entire bottom surface of the container body. Using a packaging container composed of sterilized paper, storing the medicine-filled syringe enclosed in the packaging container in a chamber as a sterilizer, and supplying hydrogen peroxide gas to the chamber decompressed to 10 to 30 torr After sterilization by repeating a plurality of times, hydrogen peroxide gas is degassed from the inside of the packaging container while heating.

  In the sterilization method described above, the medicine-filled syringe as a medical product is sterilized with hydrogen peroxide gas that has passed through the sterilized paper in the packaging container. At that time, the operation of supplying the hydrogen peroxide gas to the decompressed chamber is repeated a plurality of times, so that the hydrogen peroxide gas penetrates quickly and reliably into the inside of the packaging container. Then, after the above treatment, heating is performed to promote desorption of the hydrogen peroxide gas adsorbed on the container body, and the hydrogen peroxide gas remaining inside the packaging container is removed.

  Further, in the above sterilization method, after sterilization, the hydrogen peroxide gas contained in the circulation air is decomposed by a catalytic reaction while circulating the heated air to the chamber. In the degassing process, the hydrogen peroxide gas concentration in the chamber is always kept low, and the hydrogen peroxide gas can be degassed efficiently and safely.

  According to the sterilization method of the present invention, after sterilizing with hydrogen peroxide gas, the hydrogen peroxide gas adsorbed on the container body is removed by degassing the hydrogen peroxide gas from the inside of the packaging container while heating. Desorption can be promoted. Furthermore, while circulating the heated air, the hydrogen peroxide gas contained in the circulating air is decomposed by a catalytic reaction, so that the concentration of the surrounding hydrogen peroxide gas is always kept lower than the inside of the packaging container, Since the sterilized paper is permeated by the concentration difference, the degassing process can be performed more efficiently and the residual hydrogen peroxide gas can be surely prevented. Therefore, in a medical sterilization package, it is also possible to use a container body made of a polyester resin that is excellent in transparency and easy to dispose of as a container body. In particular, the degassing treatment of hydrogen peroxide gas from the packaging container by circulating hot air can be efficiently degassed as described above, and the heat load for producing hot air can be greatly reduced. Because it can be accurately decomposed into completely harmless components by catalytic decomposition, and extremely high safety is ensured not only in the sterilization process but also in the final discharge from the system. Demonstrates remarkable utility.

  An embodiment of a sterilization method in a medical sterilization package according to the present invention will be described with reference to the drawings. FIG. 1 is a process diagram showing each operation process of the sterilization method according to the present invention. FIG. 2 is a system diagram showing an outline of a chamber as a sterilization apparatus for carrying out the sterilization method according to the present invention. FIG. 3 is an external perspective view showing an embodiment of a packaging container in which a medicine-filled syringe is enclosed, and FIG. 4 is an exploded perspective view showing the packaging structure of the packaging container in FIG. 3 from the bottom side. FIG. 5 is a perspective view illustrating a method of handling a packaging container (packaged product) in the chamber.

  The sterilization method of the present invention is a sterilization method in so-called medical sterilization packaging in which medical products (including pharmaceuticals and medical devices) enclosed in a specific packaging container are sterilized with hydrogen peroxide gas in the packaged state. An example of a medical product suitable for medical sterilization packaging is a medicine-filled syringe (4) as shown in FIG. As is well known, the medicine-filled syringe (4) is an injection tool that is pre-filled with a required medicine and can be used immediately after the injection needle is attached. Japanese Patent Application Laid-Open No. 4-150868 discloses a technique related to such a medicine-filled syringe. It is described in gazettes.

  That is, the medicine-filled syringe (4) includes a syringe barrel (41) having a cap (42) attached to the tip needle mounting portion, and a piston rod having a piston at the tip and inserted into the syringe barrel (41). (44) and the medicine filled in the syringe barrel (41). Further, an adapter (auxiliary tool) (47) for hooking a finger during use is attached to the flange (43) of the syringe barrel (41), and the adapter (47) is attached to a packaging container to be described later. It also has a function of preventing the drug-containing syringe (4) from swinging when housed. And as a chemical | medical agent with which a syringe (4) containing a chemical | medical agent is filled, the chemical | medical agent which is not suitable for heat sterilization, typically a sodium hyaluronate solution etc. are suitable.

  As shown by the reference numeral (1) in FIG. 3, the packaging container described above is made of a synthetic resin container body (2) having gas barrier properties and is capable of permeating hydrogen peroxide gas and welded to the container body (2). It is composed of sterilized paper (3) as a possible lid. The container body (2) is integrally formed into a thin and substantially container shape with a transparent resin, and the bottom surface of the opened container body (2) is sealed with sterilized paper (3).

  As a resin material constituting the container body (2), an appropriate thermoplastic resin can be used as long as it is a material that does not permeate bacteria and allows the contents to be visually observed. From the viewpoint of gas barrier properties and transparency, The container body (2) is preferably made of a polyester-based resin such as polyethylene terephthalate (PET) or polybutylene terephthalate. Specifically, the container body (2) is produced by a molding method such as blister molding or deep drawing using a PET film having a thickness of 200 to 600 μm. In particular, the container body (2) made of a PET film does not generate a toxic gas such as chlorine like vinyl chloride at the time of disposal, and is a preferable packaging material from the viewpoint of pollution prevention.

  As shown in FIGS. 3 and 4, the container main body (2) has a first bulging portion (21) that accommodates the distal end side of the syringe barrel (41) of the medicine-filled syringe (4) when viewed externally. A second bulging portion (22) that accommodates the substantially central portion of the entire length of the medicine-filled syringe (4) including the piston rod (44) inserted partway, and a flange (43) of the syringe barrel (41) And a third bulge portion (23) for accommodating the pusher (end diameter enlarged portion) (45) of the piston rod (44), and two constricted portions (24) for coupling these bulge portions ( 24).

  The first bulging portion (21) and the third bulging portion (23) of the container body (2) form a relatively large space on both ends of the medicine-filled syringe (4), and the syringe barrel (41) Functions as a temporary storage of sterilizing gas that diffuses into details such as the gap between the piston rod and the piston rod (44), and the second bulge (22) in the center is filled with drug from the packaging container (1). It functions as a folding fulcrum of the container body (2) for taking out the syringe (4) easily and hygienically.

  On the other hand, each of the constricted portions (24) of the container body (2) forms a gap with the upper or lower packaging container (1) when many are stacked in a sterilization process to be described later. Make the flow better. Furthermore, from such a viewpoint, the first bulging portion (21) and the third bulging portion (23) of the container body (2) are configured as support points when stacked, and the second bulging portion (22) is preferably formed at a lower height than the first bulging portion (21) and the third bulging portion (23). In a preferred embodiment, the center of the third bulging portion (23) has a saddle-shaped depression (in the lower or upper packaging container (1) in order to reduce the contact area with the sterilized paper (3). 25) is formed.

  As the sterilized paper (3), a material that does not permeate microorganisms such as bacteria and can permeate gas such as sterilization gas or air, for example, high-density polyethylene known as a trade name “Tyvek 1073B” manufactured by DuPont. These sheet materials are preferably used. Such sterilized paper (3) is hermetically welded by ultrasonic welding or heat welding after accommodating the above-mentioned syringe (4) containing the medicine in the container body (2).

  Moreover, when implementing the sterilization method of this invention, the chamber (5) as a sterilizer as shown in FIG. 2 is used. The chamber (5) is designed, for example, as a horizontally-tight pressure-resistant container that can be hermetically sealed, and is configured such that a pallet on which a packaging container (packaged product) (1) (see FIG. 5) is loaded can be loaded from a door on one end face. The The chamber (5) is provided with a hydrogen peroxide gas supply line (A), a decompression line (B), an air introduction line (C) and a hot air circulation line (D), and a decompression line ( B) and a hot air circulation line (D) are provided with a catalyst device (54) for hydrogen peroxide gas decomposition.

  The hydrogen peroxide gas supply line (A) includes a mechanism for metering and metering a fixed amount of hydrogen peroxide solution and a gas generation system for heating and gasifying the supplied solution. And a pipe (71) extended from the hydrogen peroxide generator (51) through the gate valve (61) into the chamber (5). At the tip of the pipe (71), A plurality of nozzles (81) are provided via the branch pipe.

  The decompression line (B) includes a vacuum pump (52), and a pipe (72) extending from a plurality of suction ports (82) provided on the other side end surface of the chamber (5) to the suction side of the vacuum pump (52). The pipe (73) and the gate valve (62) connected to the exhaust side of the vacuum pump (52), and the catalyst device (54) for detoxifying the hydrogen peroxide gas discharged from the chamber (5). On the exhaust side of the catalyst device (54), a gate valve (63) for releasing oxygen gas generated by the decomposition treatment is provided. In addition, as a vacuum pump (52), in order to avoid the quality change of the lubricating oil by hydrogen peroxide gas, a dry pump is used.

  The air introduction line (C) is constituted by a pipe branched from the pipe (71) and provided with a filter (64) and a gate valve (65) on the open end side. That is, when the gate valve (61) of the hydrogen peroxide gas supply line (A) is closed, air is introduced into the chamber (5) by opening the gate valve (65). .

  The hot air circulation line (D) is configured by sequentially connecting the catalyst device (54), the circulation fan (55), and the heater (56). For example, piping (74) extended from a plurality of inlets (83) provided on one side wall of the chamber (5) is connected to the catalyst device (54) via a gate valve (66). The circulation fan (55) is disposed at the rear stage of the catalyst device (54), and a pipe (75) extended from the exhaust side of the circulation fan (55) is connected to the heater (56). And the piping (76) which reaches the some blower outlet (84) provided in the other side wall of the chamber (5) is connected to the exit side of a heater (56). As described above, the catalyst device (54) is installed to decompose the hydrogen peroxide gas in both the decompression line (B) and the hot air circulation line (D), and the catalyst device (54). As this, a known apparatus containing a reducing agent such as platinum is used.

  As shown in FIG. 1, the sterilization method of the present invention using the chamber (5) is carried out along the operation steps of Step (S1) to Step (S8). First, a packaging container (packaged product) (1) to be sterilized is loaded on a cart and the entire cart is loaded into a chamber. At that time, as shown in FIG. 5, the packaging containers (1) are arranged in a large number of rows (only one row is illustrated) and are loaded on a cart in a state where they are stacked in a number of stages in the vertical direction. (Step (S1)).

  Next, after closing the chamber (5), the gate valves (62) and (63) of the decompression line (B) are opened (the gate valve (66) of the hot air circulation line (D) is closed) and the vacuum pump (52) is started, and the inside of the chamber (5) is depressurized to about 10 to 30 torr by exhausting the internal air through the suction port (82), the pipes (72), (73) and the catalyst device (54). . By such an operation, in the loaded packaging container (1), the internal air is exhausted through the sterilized paper (3). (Step (S2))

  In the operation of the above step (S2), the degree of vacuum in the chamber (5) should be high to some extent so that the hydrogen peroxide gas sufficiently penetrates into the packaging container (1). When air is mixed in the syringe (4), the piston rod (44) may jump out of the syringe barrel (41) unnecessarily, so it is preferable to set the vacuum level as described above.

  Subsequently, the vacuum pump (52) of the decompression line (B) is stopped or switched to idling operation, the gate valves (62) and (63) are closed, and then hydrogen peroxide gas is supplied from the hydrogen peroxide gas supply line (A). Supply gas. The hydrogen peroxide gas is diffused into the chamber (5) through the pipe (71) and the plurality of nozzles (81) by opening the gate valve (61) and operating the hydrogen peroxide generator (51). (Step (S3)).

  After supplying the hydrogen peroxide gas, the state in which the gas is filled in the chamber (5) is maintained for about 1 to 10 minutes, and the inside of the packaging container (1) including the medicine-filled syringe (4) is sterilized. Since the inside of the packaging container (1) is negative pressure in advance by the decompression operation in the above step (S2), the sterilized paper (3) is permeated and hydrogen peroxide gas is further injected into the packaging container (1). It can be efficiently penetrated (step (S4)).

  By the way, when sterilizing a medical product with a simple shape, a single sterilization operation is sufficient, but when sterilizing a packaging container (1) in which a syringe (4) containing a medicine as described above is sealed, an injection is performed. It is necessary to sterilize over details such as the gap between the cylinder (41) and the piston rod (44). Therefore, the above-described sterilization operation, that is, the operation of supplying the hydrogen peroxide gas to the decompressed chamber (5) is repeated a plurality of times. Specifically, the operations from step (S2) to step (S4) are repeated 1 to 12 times. Thereby, hydrogen peroxide gas can be made to osmose | permeate reliably to the detail of the syringe (4) containing a chemical | medical agent.

  When the sterilization operation has been completed a predetermined number of times, the hydrogen peroxide gas supply line (A) is closed and the decompression line (B) is activated again to exhaust the hydrogen peroxide gas from the chamber (5). To do. That is, the gate valve (61) of the hydrogen peroxide gas supply line (A) is closed, the gate valves (62) and (63) of the decompression line (B) are opened, and the vacuum pump (52) is operated. Exhaust the hydrogen peroxide gas inside. At that time, the hydrogen peroxide gas is decomposed into oxygen and water by the catalyst device (54), safely exhausted out of the system, and the inside of the chamber (5) is depressurized to about 10 to 30 torr (step ( S5)).

  Next, the decompression line (B) is closed, and air is introduced into the chamber (5) through the air introduction line (C). In the air introduction operation, air is introduced through the filter (64), the pipe (71), and the plurality of nozzles (81) by opening the gate valve (65), and the inside of the chamber (5) is restored to atmospheric pressure. Pressed. And after making the inside of a chamber (5) atmospheric pressure, a gate valve (65) is closed (step (S6)).

  Subsequently, the hydrogen peroxide gas remaining inside the packaging container (1) is removed. The removal of hydrogen peroxide gas can be removed to some extent by just exposing it to air, but depending on the problem that it must be left for a very long time, and the material of the container body of a packaging container such as the above-mentioned polyester resin such as PET Has a problem that it cannot be completely removed due to the high adsorption power of hydrogen peroxide gas. Therefore, in the present invention, the hydrogen peroxide gas is degassed from the packaging container (1) while heating. As a result, the desorption of the hydrogen peroxide gas from the container body (2) is promoted, the hydrogen peroxide gas can be degassed more quickly, and the remaining hydrogen peroxide gas can be reliably prevented. And as said heating method, the method of circulating the heated air with respect to a chamber (5) is preferable.

  Specifically, the gate valve (66) of the hot air circulation line (D) is opened, and the circulation fan (55) and the heater (56) are operated. The circulation fan (55) sucks the air in the chamber (5) sucked from the plurality of intake ports (83) into the catalyst device (54) through the pipe (74), and the hydrogen peroxide gas is absorbed by the catalyst device (54). The removed air is supplied to the heater (56) through the pipe (75), and the air heated by the heater (56) is returned to the chamber (5) through the plurality of outlets (84) (step ( S7)).

  In the step (S7), the temperature of the chamber (5) is set, that is, the heater (56) is adjusted to adjust the temperature of the packaging container (30 to 120 ° C., preferably 30 to 100 ° C.). It is important to degas the hydrogen peroxide gas from the inside of 1). The reason for specifying the temperature condition is as follows. That is, when the temperature of the hot air is lower than 30 ° C., it is difficult to desorb the hydrogen peroxide gas from the surface of the polyester resin film of the container body (2), so that the degassing efficiency is lowered. When the temperature is higher than 120 ° C, the medicine filled in the medicine-filled syringe (4) is substantially higher than 100 ° C and may be deteriorated.

  The degassing treatment in step (S7) is usually performed for about 30 to 120 minutes, and the hydrogen peroxide gas remaining inside the packaging container (1) is discharged through the sterilized paper (3). Decomposition is performed by the catalyst device (54) of D). That is, the hydrogen peroxide gas concentration in the chamber (5) is constantly reduced by decomposing the hydrogen peroxide gas contained in the circulating air by catalytic reaction while circulating the heated air to the chamber (5). The hydrogen peroxide gas is degassed efficiently and safely while maintaining the state. And after degassing the hydrogen peroxide gas as described above, the hot air circulation line (D) is stopped and the treated packaging container (1) is taken out from the chamber (5) (step (S8)). .

  After the degassing process, that is, after the operation of step (S7), the atmosphere may be once introduced into the chamber (5). By supplying fresh air to the chamber (5), the temperature of the inside of the chamber (5) and the packaging container (1) can be lowered, and the subsequent process can be handled immediately. Moreover, even if a small amount of hydrogen peroxide gas remains due to malfunction of the catalyst device (54), safety can be ensured by replacing the air in the cabinet.

  As described above, in the sterilization method of the present invention, the packaging container is composed of a container main body (2) made of a specific material and sterilized paper (3), and the container main body (2) has a specific shape. Since the packaging container (1) is used, even if it is exposed to gas in a stacked state, the contact area with the upper or lower packaging container (1) is small, and the sterilized paper (3) of the packaging container (1) Contact efficiency with hydrogen peroxide gas and air can be increased, and rapid sterilization and degassing can be performed.

  Then, after sterilizing with hydrogen peroxide gas, the hydrogen peroxide gas from the container body (2) is degassed from the inside of the packaging container (1) under hot air conditions of a predetermined temperature. Since the desorption of the gas can be promoted, the degassing process can be performed efficiently and the residual hydrogen peroxide gas can be reliably prevented. Moreover, in the degassing treatment of the hydrogen peroxide gas, the hydrogen peroxide gas in the chamber (5) is decomposed by catalytic reaction while the heated air is circulated and the hydrogen peroxide gas contained in the circulating air is decomposed. Since the concentration is always kept lower than the inside of the packaging container (1) and the sterilized paper (3) is permeated by the concentration difference, the hydrogen peroxide gas inside the packaging container (1) is more efficiently degassed. It can be processed. Therefore, it is also possible to use a polyester resin container body having excellent transparency and easy disposal as the container body (2).

  In this connection, a medicine-filled syringe (4) comprising a container body (2) made of PET film and a sterilized paper (3) made of the above-mentioned “Tyvek” and comprising a packaging container (1) and filled with sodium hyaluronate as a medicine. Was enclosed in a packaging container (1). Then, it was divided into two treatment lots (a) and (b), and each lot was sterilized with hydrogen peroxide gas using the chamber (5) shown in FIG. In that case, the lot (a) is sterilized by the sterilization method of the present invention, and the lot (b) is subjected to steps (S1) to (S6) in FIG. It was left in the air and degassed. As a result, in lot (a), the hydrogen peroxide gas could be completely removed by the degassing treatment (step (S7)) for 2 hours, whereas in lot (b), the packaging container after 6 hours. From (1), it was confirmed that about 100 ppm of hydrogen peroxide remained.

  In the present invention, in particular, the degassing operation of the hydrogen peroxide gas from the packaging container (1) by circulating hot air as described above exhibits a remarkable effect from the industrial and environmental viewpoints. That is, according to the above degassing operation, it is possible to greatly reduce the amount of air that is used in the degassing process and that may contain hydrogen peroxide gas but may contain hydrogen peroxide gas, and to produce hot air. The heat load for doing so can be greatly reduced. In order to further promote the degassing effect, it is desirable to reduce the concentration of hydrogen peroxide gas in the air returned to the chamber as much as possible. However, by using a catalyst and further raising the temperature of the circulating air, it is ensured. And hydrogen peroxide gas in circulating air can be processed safely. In addition, since hydrogen peroxide gas is used as the sterilization gas, it can be accurately decomposed into completely harmless components by catalytic decomposition, so it is extremely safe not only for sterilization but also for final discharge to the outside of the system. Is secured.

It is process drawing which shows each operation process of the sterilization method which concerns on this invention. It is a systematic diagram which shows the outline | summary of the chamber as a sterilizer. It is an external appearance perspective view which shows one form of the packaging container with which the injection syringe containing a chemical | medical agent was enclosed. It is an expansion | deployment perspective view which shows the packaging structure of the packaging container in FIG. 3 from the bottom face side. It is a perspective view which shows the handling method of the packaging container (packaged product) in a chamber.

Explanation of symbols

1: Packaging container 2: Container body 3: Sterilized paper 4: Syringe containing medicine 5: Chamber 51: Hydrogen peroxide gas generator 52: Vacuum pump 54: Catalytic device 55: Circulation fan 56: Heater 64: Filter 81: Nozzle 82: Suction port 83: Air intake port 84: Air outlet

Claims (7)

  A sterilization method for sterilizing a syringe containing a medicine as a medical product enclosed in a packaging container with hydrogen peroxide gas, and as a packaging container, an integrated unit made of a synthetic resin having gas barrier properties and having the entire bottom surface opened Uses a packaging container composed of a molded container body and sterilized paper as a lid material that is permeable to hydrogen peroxide gas and can be welded to the entire bottom surface of the container body, and a medicine enclosed in the packaging container The syringe was placed in a chamber as a sterilizer and sterilized by repeating the operation of supplying hydrogen peroxide gas to the chamber depressurized to 10 to 30 torr, and then was oxidized from the inside of the packaging container while heating. A method for sterilization in medical sterilization packaging, characterized by degassing hydrogen gas.   The sterilization method according to claim 1, wherein the hydrogen peroxide gas is degassed by decomposing the hydrogen peroxide gas contained in the circulating air by a catalytic reaction while circulating the heated air to the chamber.   The sterilization method according to claim 2, wherein the atmosphere is introduced into the chamber after the degassing treatment.   As a chamber, a hydrogen peroxide gas supply line, a decompression line, an air introduction line, and a hot air circulation line are attached, and a catalyst device for decomposing hydrogen peroxide gas in the decompression line and the hot air circulation line. The sterilization method according to any one of claims 1 to 3, wherein a chamber in which is installed is used.   The sterilization method according to any one of claims 1 to 4, wherein the medicine filled in the medicine-filled syringe is a sodium hyaluronate solution.   The sterilization method according to any one of claims 1 to 5, wherein the sterilization treatment is followed by heating to 30 to 120 ° C.   The sterilization method according to any one of claims 1 to 6, wherein the container body includes a constricted portion that forms a gap with the upper or lower packaging container when a large number of the container bodies are stacked.

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