JP2006159043A - Rotary type microchannel emulsification method, device for performing the same and prepared emulsified suspension and particulate - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a rotary type microchannel emulsification method for stably preparing particulates having uniform particle diameters, and to provide a rotary type microchannel emulsification device for performing the method. <P>SOLUTION: In the rotary type microchannel emulsification method where particulates having uniform particle diameters are stably prepared, (1) a circular substrate having at least one or more optional flow passage patterns with a width of 1 to 1,000 μm and a depth of 1 to 1,000 μm is comprised, (2) extrusion or centrifugal force is acted on each flow passage in the circular substrate from the vicinity of the center of the circular substrate, thus at least one or more kinds of fluids are made to flow to a radial direction, (3) the vicinity of the center in the circular substrate is provided with an inlet structure, each passage edge or intermediate part is provided with an outlet part, and each fluid passed through each passage is contacted with the external fluid at the outlet part, and (4) the circular substrate or sidewall is rotated at a rotational speed of 0 to 5,000 mm/s, and high shearing can be uniformly applied to all the fluids made to flow out from the plurality of passage edges. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a rotating microchannel emulsification method using a rotating body having a fine channel structure, an apparatus for performing the emulsification method, an emulsified suspension and fine particles prepared by the emulsification method.

Emulsified suspensions and fine particles obtained therefrom are used in various industrial applications, and various techniques are used for industrial production of emulsified dispersions (for example, Patent Documents 1 to 5 and Non-Patent Documents). Patent Document 1).
Patent Document 1 discloses a toner production method using a film emulsification method, Patent Document 2 discloses emulsification using a homogenizer, and Patent Document 3 discloses ultrasonic emulsification. In these techniques, a substance to be dispersed in fine particles is put into a liquid called a continuous phase, and a shearing force is repeatedly applied by giving a mechanical action to obtain an emulsified dispersion. Since the shearing force is not uniform depending on the emulsification position, polydispersed fine particles are generated.
On the other hand, in emulsification using a porous glass membrane in Patent Document 4, the dispersed phase and the continuous phase are partitioned by the porous glass membrane, and the dispersed phase is formed by pushing the dispersed phase to the continuous phase side. In this method, the dispersed phase comes into contact with the continuous phase, the surface tension becomes shearing force, and the dispersed phase is finally finely divided to obtain an emulsified dispersion.
However, the particle diameter of the generated fine particles depends on the non-uniformity of the pore diameter of the porous glass film, and polydispersed fine particles are generated.
When using fine particles as cosmetics, liquid crystal spacers, polymerized toners, display devices for electronic paper, etc., the monodispersity of the fine particles is required, so the conventional methods described in Patent Documents 1 to 3 as described above. There was a problem that fine particles used in cosmetics, polymerized toners and the like could not be obtained.
Therefore, as a method for producing an emulsified dispersion or fine particles having a high degree of monodispersibility, microchannel emulsification described in Patent Document 5 can be mentioned.
JP 7-120974 A Japanese Patent No. 3476223 Japanese Patent No. 3218445 Japanese Patent No. 2733729 JP 2000-273188 A Nishisako et al. (Lab on a Chip, vol.2, 24-26, 2002)

However, in the production method described in Patent Document 5, the membrane separating the dispersed phase and the continuous phase has an artificially uniform structure, and the standard deviation of the diameter of the fine particles / the average diameter of the fine particles is 0.03 or less. Although finely dispersed fine particles can be obtained, it is considered that there is a problem of clogging when a fine particle liquid is used in a dispersed phase because the size of each channel is small with respect to particles of a desired size.
In addition, as research on microchannel emulsification, the research of Non-Patent Document 1 can be cited. According to the method described in this document, monodispersed fine particles can be obtained, but the number of channels is increased, and microchannel chips are arranged in parallel. Therefore, when improving the production efficiency, it is considered difficult to send the liquid evenly to all the channels.
Accordingly, the present invention is to solve the conventional problems and to provide a rotating microchannel emulsification method for stably producing fine particles having a uniform particle diameter and a rotating microchannel emulsification device for carrying out this method.

In order to solve the above problems, the invention according to claim 1 is a rotary microchannel emulsification method for stably producing fine particles having a uniform particle size.
(1) including a circular substrate having at least one arbitrary flow path pattern having a width of 1 to 1000 μm and a depth of 1 to 1000 μm,
(2) By causing “extrusion” or “centrifugal force” to act on the flow path in the circular substrate from the vicinity of the center of the circular substrate, at least one kind of fluid is caused to flow in the radial direction,
(3) An entrance structure is provided near the center of the circular substrate, an exit portion is provided at the end of the flow path or an intermediate portion, and the fluid that has passed through the flow path contacts an external fluid at the exit portion;
(4) The circular substrate or the side wall rotates at a rotational speed of 0 to 5000 mm / s, and high shear can be uniformly applied to all the fluids flowing out from a plurality of flow path ends.
The invention described in claim 2 is characterized in that, in the invention described in claim 1, a circular substrate made of glass, silicon, metal or plastic resin material is used.
A third aspect of the invention is characterized in that, in the first or second aspect of the invention, the wall surface of one portion of the flow path pattern is subjected to a hydrophilic or hydrophobic treatment.
The invention according to claim 4 is characterized in that, in the invention according to any one of claims 1, 2, or 3, a catalyst is supported on a wall surface of one part of the flow path pattern.
The invention according to claim 5 is the invention according to any one of claims 1 to 4, characterized in that at least two or more fluids contact and mix in one part of the flow path pattern. And
The invention according to claim 6 is the invention according to any one of claims 1 to 5, wherein an outlet portion of the flow path pattern protrudes.
According to a seventh aspect of the present invention, in the invention according to any one of the first to sixth aspects, the side wall is disposed at a distance of 1 μm or more from the outlet end portion of the flow path pattern, and between the circular substrate wall and the side wall. And at least one kind of fluid is allowed to flow.
The invention according to claim 8 is the invention according to any one of claims 1 to 7, wherein the flow path is formed by discontinuously rotating a circular substrate having the flow path pattern or a side wall disposed in the vicinity of the circular substrate. It is characterized in that a uniform shearing force can be applied to the exit portion of the pattern.
The invention according to claim 9 is the invention according to any one of claims 1 to 8, wherein the circular substrate having the flow path pattern rotates to give a centrifugal force to the fluid in the flow path. .
The invention described in claim 10 is characterized in that, in the invention described in any one of claims 1 to 9, at least two circular substrates having a plurality of flow path patterns are laminated.
The invention according to claim 11 is the invention according to any one of claims 1 to 10, wherein the dispersed phase is “a suspension in which a resin is dissolved” or “a polymer monomer containing a polymerization initiator”. It is characterized by being a mixed solution containing pure water or ion-exchanged water in a phase and an emulsifier such as a surfactant.

The invention according to claim 12 is the invention according to any one of claims 1 to 11, wherein the dispersed phase is a mixed solution containing pure water or ion-exchanged water and an emulsifier and the like, and the resin is dissolved in the continuous phase. It is characterized by being a “suspension” or a “polymer monomer containing a polymerization initiator”.
The invention described in claim 13 is characterized in that the emulsion suspension is prepared by the rotating microchannel emulsification method described in any one of claims 1 to 12.
The invention according to claim 14 is characterized in that the fine particles are obtained from an emulsified suspension prepared by the rotating microchannel emulsification method according to any one of claims 1 to 12.
The invention according to claim 15 is provided with a flow path pattern comprising at least one arbitrary groove having a width of 1 to 1000 μm and a depth of 1 to 1000 μm, and the surface on which the grooves are formed is covered with a flat plate or the like. Covering with a material opens only the entrance / exit of the groove and the flow path is a closed space, a rotating mechanism that rotates around the center of the circular substrate, and fluid to be inserted near the center of the circular substrate And a rotating type microchannel emulsifying device having an opening.
According to a sixteenth aspect of the present invention, in the fifteenth aspect of the invention, the circular substrate is disposed in a container filled with a fluid that is a continuous phase, and is a dispersed phase from an opening provided near the center of the circular substrate. Fluid is discharged into an opening provided on the outer periphery of the circular substrate through a flow path pattern provided on the circular substrate by centrifugal force accompanying the rotation of the circular substrate or pressure of a pump, etc., and a continuous phase filled in the container A shear stress is generated in the fluid that is the dispersed phase by a difference in relative velocity between the fluid that is the fluid and the fluid that is the dispersed phase released from the flow path pattern.
The invention according to claim 17 is the invention according to claim 15 or 16, characterized in that the circular substrate is made of glass, silicon, metal or plastic resin material.

The invention according to claim 18 is characterized in that, in the invention according to claim 15 or 17, the wall surface of a part of the flow path pattern is subjected to hydrophilic or hydrophobic treatment.
The invention according to claim 19 is the invention according to any one of claims 15 to 18, characterized in that a catalyst is carried on a wall surface of a part of the flow path pattern.
The invention according to claim 20 is the invention according to any one of claims 15 to 19, wherein at least two flow path patterns having different entrances are joined at an arbitrary position in the radial direction of the circular substrate. It is characterized by.
The invention according to claim 21 is the invention according to any one of claims 15 to 20, characterized in that an outlet portion of the flow path pattern protrudes.
The invention according to claim 22 is the invention according to any one of claims 15 to 21, wherein a side wall is disposed at a distance of 1 μm or more from an outlet end portion of the flow path pattern, and the circular substrate wall and the side wall are arranged. At least one type of fluid is allowed to flow between the two.
The invention according to claim 23 is the invention according to any one of claims 15 to 22, wherein the side wall disposed in the vicinity of the circular substrate having the flow path pattern or in the vicinity of the circular substrate is rotated discontinuously. A uniform shearing force can be applied to the outlet portion of the flow path.
A twenty-fourth aspect of the invention is the invention according to any one of the fifteenth to twenty-third aspects, wherein the circular substrate having the flow path pattern rotates to give a centrifugal force to the fluid in the flow path. And
The invention according to claim 25 is the invention according to any one of claims 15 to 24, wherein at least two circular substrates having a plurality of flow path patterns are laminated.

  According to the present invention, by providing a rotation mechanism for rotating the circular substrate, a centrifugal force is generated in the fluid, and this can be used as one of the driving force sources of the fluid. Further, by providing a rotation mechanism for rotating the circular substrate, a shearing force can be generated between the fluid and the external fluid. Furthermore, by arranging a plurality of the same flow paths in the circular substrate, it is possible to apply a shearing force to all the flow paths extremely uniformly.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. FIG. 1 is a plan view for explaining a circular substrate used in an apparatus for carrying out a microchannel emulsification method according to the present invention. FIG. 2 is a schematic view for explaining the rotating mechanism of the circular substrate. FIG. 3 is a plan view showing a circular substrate having a plurality of flow paths.
1 to 3, the rotary microchannel emulsification apparatus has a circular substrate 1 on which at least one channel structure (channel pattern) for allowing fluid to pass is mounted. The channel has a depth of 1 to 1000 μm and a width of 1 to 1000 μm, and the cross section is not limited to a rectangle, but may be an ellipse, a trapezoid, a triangle, or the like, and a part of the channel may have a different shape.
As shown in FIG. 1, the opening 2 is an entrance structure for inserting a fluid from the center side of the circular substrate 1 near the center of the rotating shaft 1 ′ of the circular substrate 1, and is connected to the opening 2. And an opening 4 for discharging the fluid to the outside of the circular substrate 1 at the outermost part of the circular substrate 1.
The material of the circular substrate 1 is glass, silicon, metal, or plastic resin material, and a groove shape processing having a width of 1 to 1000 μm is performed by a fine processing method such as photography, etching, machining, laser processing, etc. It is formed.
The grooved circular substrate 1 and a covering material such as a flat plate are joined together by an appropriate method, and a space other than the opening provided at the end of the circular substrate 1 becomes a closed space. This makes it possible to duplicate a substrate in large quantities and at low cost by using a microfabrication method currently applied for general purposes.
The channel wall surface is subjected to ozone treatment, plasma treatment, hydrophilic treatment with hydrophilic resin silicon, or hydrophobic treatment by fluorination treatment, or titanium oxide whose hydrophilicity / hydrophobicity can be controlled by light. This makes it easier to control the flow resistance of the fluid passing through the flow path and to granulate.
Further, a catalyst may be supported on at least a part of the wall surface of the flow path. Thereby, a chemical reaction can be induced in the flow path. Furthermore, pretreatment operations such as reactors can be performed directly in the circular substrate.
By providing such a rotating mechanism (not shown) for rotating the circular substrate 1, a centrifugal force acts from the center 5 of the circular substrate 1 to the outer periphery of the circular substrate 1 as shown in FIG. It moves from the opening 2 through the flow path 3 to the opening 4.

FIG. 3 is a diagram showing a circular substrate 1 provided with a plurality of flow paths. For example, channels 1 to 5 are provided as flow paths 3, and openings 4 that are the outlets of these flow paths 3 are the same from the center of the circle. Provide at distance.
By using the circular substrate 1 configured as described above, in the microchannel emulsification method according to the present invention, a centrifugal force is generated in the fluid A, and this can be used as one of the driving force sources of the fluid A. . Further, by providing a rotation mechanism for rotating the circular substrate 1, a shearing force can be generated between the fluid A flowing out from the opening 4 of the circular substrate 1 and the external fluid outside the opening 4. Furthermore, by arranging a plurality of the same flow paths in the circular substrate 1 as shown in FIG. 3, it is possible to give the above-described effect very uniformly in all the flow paths. Here, the fluid refers to “liquid” or “gas” or “dispersed liquid of solid particulate matter”.
In the opening 4 that is the outlet of the flow path 3 provided near the outermost end of the circular substrate 1, the dispersed phase that has flowed through the flow path 3 is in contact with a continuous phase that is an external fluid that flows around the circular substrate 1. . At this time, when the circular substrate 1 rotates or the continuous phase on the outer periphery of the circular substrate 1 flows, shear is generated in the dispersed phase released from the flow path 3 of the circular substrate 1, and this shearing force is circular. It can be controlled by changing the rotation speed of the substrate 1 or the flow rate of the continuous phase on the outer periphery of the circular substrate 1.
FIG. 4 is a schematic view showing a situation where the dispersed phase 6 that has passed through the flow path 3 and the continuous phase 7 around the circular substrate 1 are in contact with each other in the opening 4 that is the outlet of the flow path 3. In microchannel emulsification or membrane emulsification, the dispersed phase 6 flows out from the opening 4 of the flow path 3 as shown in FIG. 4, and the dispersed phase 6 and the continuous phase 7 come into contact with each other. At that time, when the contact area between the dispersed phase 6 and the continuous phase 7 exceeds a certain value, fine particles are generated due to separation of the dispersed phase 6 which is a more stable interface state.

FIG. 5 is a schematic diagram showing a case where a flow rate is given to the continuous phase 7. As shown in the figure, when the flow rate is given to the continuous phase 7, the flow rate of the continuous phase 7 that touches the circular substrate 1 and the side wall 9 is slow, and the flow rate of the continuous phase flowing away from the circular substrate 1 and the side wall 9 is high. Thus, a shearing stress as indicated by an arrow S is applied to the dispersed phase 6 and the formation of fine particles is promoted. Therefore, it is not necessary to reduce the size of each channel with respect to particles of a desired size, and it is possible to increase the amount of fine particles generated from each channel and prevent clogging of the channel.
FIG. 6 is a schematic view showing a case where the circular substrate 1 moves. FIG. 7 is a schematic view showing a case where the side wall 9 moves. 6 and 7, when the circular substrate 1 moves, the relative velocity of the continuous phase 7 adjacent to the circular substrate 1 is the fastest, and the relative velocity of the continuous phase 7 adjacent to the side wall 9 is the slowest, and its velocity distribution. Becomes the arrow S. On the other hand, when the side wall 9 moves as shown in FIG. 7, the velocity distribution of the continuous phase 7 is as indicated by an arrow S.
FIG. 8 is a plan view showing an embodiment of a rotating microchannel emulsification method and apparatus according to the present invention. FIG. 9 is a cross-sectional view of the embodiment of FIG. In these figures, 1 is a circular substrate, 2 is an opening for allowing a dispersed phase to flow in, 3 is a flow path, 4 is an opening which is an outlet of the flow path, 11 is a continuous phase supply section, and 12 is a dispersion outlet. , 13 are cylindrical containers.
In the rotary microchannel emulsification apparatus configured as described above, the continuous phase 7 is supplied to the cylindrical container 13 from the continuous phase supply unit 11 at a constant volume velocity. Further, since the circular substrate 1 rotates around an axis arranged at the center of the cylindrical substrate, the dispersed phase supplied from the opening 2 is pushed by centrifugal force and the opening 4 provided in the arc of the circular substrate 1. More discharged to continuous phase 7 and emulsified by shearing. In addition, you may supply a disperse phase using not only the centrifugal force by rotation of the circular board | substrate 1 but a pump.
The emulsified dispersion (not shown) is recovered from the dispersion outlet 12 provided at the lower part when the density is larger than the continuous phase 7. Further, when the density of the emulsified dispersion is smaller than the continuous phase 7, the dispersion outlet 12 is disposed at the upper part of the circle and the cylindrical container 13 and recovered therefrom.

FIG. 10 is a schematic view showing an opening 2 which is a dispersed phase entrance structure provided near the rotation axis 1 ′ of the circular substrate 1. As shown in FIG. 10, the fluid is introduced from the opening 2 provided near the rotating shaft 1 ′, and the reaction is started at the catalyst supporting portion 17 provided in a part of the flow path, and the reaction is continuing or completed. Later, it is led to a continuous phase 18 stream.
FIG. 11 is a plan view and a sectional view showing another embodiment of the rotary microchannel emulsification method and apparatus according to the present invention. A difference from the circular substrate shown in FIG. 1 is that at least two flow paths 3A and 3B having different entrances are provided, and these are connected at arbitrary positions, so that at least two kinds of fluids can be mixed.
The fluid A and the fluid B are introduced into the circular substrate 1 from different inlets 19 and 20, mixed until reaching the outlet 4 from the joining portion 21 of the two fluids, and are led to a continuous phase flow. The flow path 3A is provided with an outlet portion at a radial intermediate portion of the circular substrate 1, and is connected to the flow path 3B.
FIG. 12 is a schematic diagram showing the outlet structure of the flow path 3 having a structure protruding from the outer periphery of the circular substrate 1, where the flow path outlet 22 protrudes into the continuous phase 7 and the dispersed phase 6 is the end face of the circular substrate. Fine particles without any interaction. Thereby, the area which the disperse phase 6 contacts with the continuous phase 7 becomes large, and receives a shearing force more. Furthermore, since it does not adhere to the end wall surface of the circular substrate, efficient emulsification becomes possible.
FIG. 13 is a schematic view showing the shear stress applied to the dispersed phase 6 in the structure in which the end portion (circumference) of the circular substrate 1 and the side wall 9 serve as a flow path. When the side wall rotates, the flow rate of the continuous phase 7 close to the side wall 9 is high and the flow rate of the continuous ancestor 7 close to the circular substrate 1 is slow as shown in FIG. It becomes possible to apply the shear stress as shown to the dispersed phase 6.

14 to 17 are diagrams showing an example of a change in the rotational speed of the circular substrate 1 or the side wall 9. FIG. 14 is a diagram showing a change in rotational speed-time when the circular substrate 1 or the side wall is rotated at a constant speed without changing the rotational speed with the passage of time, and FIG. FIG. 16 is a diagram showing a change in rotational speed-time when the rotational speed of 1 or the side wall is changed. FIG. 16 shows that the rotational speed of the circular substrate 1 or the side wall 9 becomes positive (forward rotation) and negative (reverse rotation) at regular intervals. FIG. 17 is a diagram showing a change in the rotation speed-time when changing. FIG. 17 shows the rotation speed-time in the case where the rotation speed of the circular substrate 1 or the side wall 9 is continuously changed to plus (forward) and minus (reverse). It is a figure which shows a change. As described above, the generation of the satellite fine particles, which is a concern during continuous rotation, can be reduced by changing the rotation speed of the circular substrate 1 or the side wall 9 in various ways, instead of making it constant.
As described above, in the apparatus for carrying out the microchannel emulsification method according to the present invention, the centrifugal force acts on the fluid in the flow path by the rotation of the circular substrate and is pushed out in the radial direction of the circular substrate. The pushing force can be uniformly applied to all the channels having the same shape on the rotating substrate. However, by stacking a plurality of circular substrates 1 on the same axis as shown in FIG. It may be increased. Thus, by laminating a plurality of circular substrates 1 on the same axis, the number of channels can be increased to an arbitrary number, and the relative speeds of the disperse phase (not shown) generated by rotation and the continuous phase 7 can be all Since it can give uniformly in a channel, the particle diameter of the microparticles | fine-particles produced | generated from all the channels becomes very uniform.
In addition, since the number of channels can be increased, an increase in the fine particle production rate can be obtained, and the same flow rate condition can be given to all the channels. Easy to do.

The dispersed phase 6 is a suspension in which a resin is dissolved or a polymer monomer containing a polymerization initiator, and the continuous phase 7 is a mixture of pure water or ion-exchanged water containing an emulsifier such as a surfactant. A liquid can be used. Thereby, an O / W (Oil in Water) emulsion is obtained in the emulsification system of this structure. In addition, since various oils, fine particle dispersions, and monomers can be selected for the oil phase, functional fine particles, for example, fine particles in which a pigment is dispersed can be produced.
Conversely, as the dispersed phase 6, a mixed solution containing pure water or ion-exchanged water and an emulsifier such as a surfactant can be used, and a suspension obtained by dissolving a resin in the continuous phase 7 can also be used. This makes it possible to create a W / O (Water in Oil) dispersion in which a water-soluble substance is dispersed. The emulsified suspension can be prepared by using the above-described emulsification method. When the emulsification method is prepared by using an O / W emulsion as the emulsification method, a dispersion of oil fine particles having a diameter of 1-1000 μm is obtained. Moreover, when it creates using W / O, it becomes a dispersion | distribution of the aqueous solution fine particle of diameter 1-1000 micrometers.
Furthermore, it is also possible to solidify O / W emulsified oils and fats by a polymerization reaction to obtain functional fine particles having a diameter of 1 to 1000 μm.
The present invention relates to fine particles and fine particle dispersions used in image display elements (polymerized toners, microcapsules for electronic paper), emulsions for drug delivery, paints, cosmetics, biodegradable emulsions, photosensitive materials, and the like, and methods for producing the same. Can be used.

It is a top view explaining the circular board | substrate used for this invention. It is the schematic explaining the rotation mechanism of a circular board | substrate. It is a top view which shows the circular board | substrate provided with the several flow path. It is the schematic which shows the contact in the exit of a dispersed phase and a continuous phase. It is the schematic which shows the case where the flow rate is given to the continuous phase. It is the schematic which shows the case where the plate of a dispersed phase side moves. It is the schematic which shows the case where the board of an opposite bank moves. It is a top view which shows embodiment of the rotation type microchannel emulsification method and apparatus by this invention. It is sectional drawing of embodiment of FIG. It is the schematic which shows the entrance structure provided near the rotating shaft. It is the top view and sectional drawing which show other embodiment of the rotation type microchannel emulsification method and apparatus by this invention. It is the schematic which shows the flow-path exit which has a structure protruded with respect to the outer periphery of a circular board | substrate. It is the schematic which shows the structure where the periphery and side wall of a circular board | substrate become a flow path. It is a figure which shows that a circular board | substrate or a side wall changes a rotational speed with respect to time with a graph. It is a figure which shows that a circular board | substrate or a side wall changes a rotational speed with respect to time with a graph. It is a figure which shows that a circular board | substrate or a side wall changes a rotational speed with respect to time with a graph. It is a figure which shows that a circular board | substrate or a side wall changes a rotational speed with respect to time with a graph. It is the schematic which shows the emulsification apparatus which has a structure where the circular board | substrate was laminated | stacked in multiple layers.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Circular substrate 1 'Rotating shaft 2 Opening part 3 Flow path 4 Opening part (exit)
5 Center of Rotating Shaft 6 Dispersed Phase 7 Continuous Phase 9 Side Wall 16 Inlet Structure 17 Catalyst Supporting Portion 22 Channel Exit (Projects)

Claims (25)

In the rotational microchannel emulsification method for stably producing fine particles having a uniform particle size,
(1) including a circular substrate having at least one arbitrary flow path pattern having a width of 1 to 1000 μm and a depth of 1 to 1000 μm,
(2) By causing “extrusion” or “centrifugal force” to act on the flow path in the circular substrate from the vicinity of the center of the circular substrate, at least one kind of fluid is caused to flow in the radial direction,
(3) An entrance structure is provided near the center of the circular substrate, an exit portion is provided at the end of the flow path or an intermediate portion, and the fluid that has passed through the flow path contacts an external fluid at the exit portion;
(4) Rotating microchannel emulsification characterized in that the circular substrate or the side wall rotates at a rotational speed of 0 to 5000 mm / s and can uniformly apply high shear to all the fluids flowing out from a plurality of flow path ends. Method.   2. The rotating microchannel emulsification method according to claim 1, wherein a circular substrate made of glass, silicon, metal or plastic resin material is used.   The rotating microchannel emulsification method according to claim 1 or 2, wherein a wall surface of one part of the flow path pattern is subjected to hydrophilic or hydrophobic treatment.   4. The rotating microchannel emulsification method according to claim 1, wherein a catalyst is supported on a wall surface of a part of the flow path pattern.   5. The rotating microchannel emulsification method according to claim 1, wherein at least two or more fluids contact and mix in one part of the flow path pattern.   The rotating microchannel emulsification method according to any one of claims 1 to 5, wherein an outlet portion of the flow path pattern protrudes.   The side wall is disposed at a distance of 1 μm or more from the outlet end portion of the flow path pattern, and at least one type of fluid is allowed to flow between the circular substrate wall and the side wall. The rotation type microchannel emulsification method as described.   8. A uniform shearing force can be applied to an outlet portion of the flow path pattern by discontinuously rotating a circular substrate having the flow path pattern or a side wall disposed in the vicinity of the circular substrate. The rotation type microchannel emulsification method of any one of these.   The rotating microchannel emulsification method according to any one of claims 1 to 8, wherein the circular substrate having the flow path pattern rotates to apply a centrifugal force to the fluid in the flow path.   The rotational microchannel emulsification method according to any one of claims 1 to 9, wherein at least two circular substrates having a plurality of flow path patterns are laminated.   The dispersion phase is a “liquid suspension in which the resin is dissolved” or “polymer monomer containing a polymerization initiator”, and the continuous phase contains pure water or ion exchange water and an emulsifier such as a surfactant. The rotational microchannel emulsification method according to any one of claims 1 to 10.   The dispersed phase is a mixed solution containing pure water or ion-exchanged water and an emulsifier, and the continuous phase is a “suspension with a resin dissolved” or a “polymer monomer containing a polymerization initiator”. The rotation type microchannel emulsification method according to any one of claims 1 to 11.   13. An emulsified suspension produced by the rotating microchannel emulsification method according to any one of claims 1 to 12.   Fine particles obtained from an emulsified suspension prepared by the rotating microchannel emulsification method according to any one of claims 1 to 12.   By providing a flow path pattern including at least one arbitrary groove having a width of 1 to 1000 μm and a depth of 1 to 1000 μm radially, and covering the surface on which the groove is formed with a covering material such as a flat plate, the groove A circular substrate whose opening and closing is opened and the flow path is a closed space, a rotation mechanism that rotates around the center of the circular substrate, and an opening for inserting fluid near the center of the circular substrate Rotating microchannel emulsifying device.   The circular substrate is placed in a container filled with a fluid that is a continuous phase, and the fluid that is a dispersed phase from the opening provided near the center of the circular substrate is subjected to centrifugal force or pressure such as a pump accompanying the rotation of the circular substrate. The fluid is a continuous phase filled in the container and discharged from the flow path pattern through the flow path pattern provided on the circular substrate to the opening provided on the outer periphery of the circular substrate. 16. The rotating microchannel emulsification device according to claim 15, wherein shear stress is generated in the fluid which is the dispersed phase based on a difference in relative velocity with the fluid.   The rotary microchannel emulsification apparatus according to claim 15 or 16, wherein the circular substrate is made of glass, silicon, metal, or plastic resin material.   The rotating microchannel emulsification device according to any one of claims 15 to 17, wherein a wall surface of one portion of the flow path pattern is subjected to a hydrophilic or hydrophobic treatment.   The rotary microchannel emulsification device according to any one of claims 15 to 18, wherein a catalyst is supported on a wall surface of a part of the flow path pattern.   20. The rotating microchannel emulsification device according to any one of claims 15 to 19, wherein at least two flow path patterns having different entrances are joined at an arbitrary position in the radial direction of the circular substrate.   21. The rotating microchannel emulsification device according to claim 15, wherein an outlet portion of the flow path pattern protrudes.   The side wall is disposed at a distance of 1 μm or more from the outlet end portion of the flow path pattern, and at least one type of fluid is allowed to flow between the circular substrate wall and the side wall. 2. A rotating microchannel emulsifying device according to item 1.   16. A uniform shearing force can be applied to the outlet portion of the flow path by discontinuously rotating the circular substrate having the flow path pattern or the side wall disposed in the vicinity of the circular substrate. 23. The rotary microchannel emulsification device according to any one of items 1 to 22.   24. The rotating microchannel emulsifying apparatus according to claim 15, wherein the circular substrate having the flow path pattern rotates to apply a centrifugal force to the fluid in the flow path.   25. The rotating microchannel emulsification device according to any one of claims 15 to 24, wherein at least two circular substrates having a plurality of flow path patterns are stacked.

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