JP2006142102A - Blister pack - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To improve medication efficiency by diffusing medical powder stored in a medical powder storage part, according to its characteristics. <P>SOLUTION: The medical powder storage part 25 of a blister pack 21 comprises a restriction passage 26 by a restriction part 23C of a swelling part 23 between an inflow hole H1 and an outflow hole H2. The flow velocity of an air stream flowing from the inflow hole H1 to the outflow hole H2 can thereby be increased by the restriction passage 26, and the air flow corresponding to the characteristics of the medical powder can be formed by adjusting the passage area of the restriction passage 26. Consequently, since the medical powder in the medical powder storage part 25 can be diffused by the air flow suitable for the medical powder and efficiently mixed into the air flow, a patient can be dosed with the specified quantity of the medical powder stored in the medical powder storage part 25. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a blister pack suitable for use in an inhalation-type dispenser that administers medicinal powder into the lungs by inhaling a patient's breath, for example.

  In general, inhalation-type dispensers used for inhaling medicinal powders filled in capsules among methods for administering medicinal powders for asthma patients, etc., have one side in the axial direction as a capsule storage chamber and the other side is medicinal powders. A prescription device main body serving as an inhalation port for inhaling air, an air passage that communicates the air side with the air suction port via the capsule housing chamber, and a drilling tool that opens a hole that communicates with the air passage in the capsule It is roughly structured.

  Further, inhalation-type dispensing devices are known that administer drug powder using blister packs in which a plurality of powder storage parts storing a single dose of drug powder are provided in the circumferential direction (for example, Patent Documents). 1 and 2).

  Furthermore, the blister pack of the prior art used for this inhalation-type prescription device includes a bottom plate on which a large number of bulges are formed, and a drug powder container that is attached to the surface side of the bottom plate and closes the bulges And a powdery medicine (medicine powder) is accommodated in the medicinal powder container.

  When administering medicinal powder, a hole is made in the blister pack by one needle-shaped plunger, and the medicinal powder container is communicated with the suction port. As a result, the patient can suck the powder in the powder container from the suction port into the lungs by sucking in through the suction port.

  Further, at the time of next medication, the blister pack is rotated, and the other powder storage unit is communicated with the suction port, so that the powder can be continuously inhaled without changing the capsule or the like.

JP 59-88158 JP-A-62-41668

  By the way, since the blister pack according to the prior art described above has a hole formed in the blister pack by a single plunger, the blister pack is formed with two holes penetrating almost straight. For this reason, the airflow which flows in into a powdery powder storage part only distribute | circulates the inside of this powdery powder storage part linearly between two holes.

  Therefore, even if the characteristics of the administered powder, such as the size of the granules (fine powder, granules, etc.), the cohesive strength, the amount of the administered powder, etc. are different, the flow rate and direction of the air flow Etc. will be constant. For this reason, since the medicinal powder stored in the medicinal powder container cannot be reliably diffused, the medicinal powder remains in the medicinal powder container, and a prescribed amount of medicinal powder cannot be administered to the patient. There is a problem that the efficacy of the powder is reduced.

  The present invention has been made in view of the above-described problems of the prior art, and an object of the present invention is to diffuse the drug powder stored in the drug powder storage unit according to its characteristics, and improve the dosing efficiency. An object of the present invention is to provide a blister pack.

  The blister pack according to the present invention comprises a bottom plate on which a bulging portion is formed, and a lid plate that is provided on the surface side of the bottom plate and closes the bulging portion to define a drug powder storage portion.

  In order to solve the above-described problem, the feature of the configuration adopted by the invention of claim 1 is that a throttle passage is provided between the inflow hole and the outflow hole that are drilled through the bulging portion. It is in.

  With this configuration, the air flow that has flowed into the powder container from the inflow hole increases the flow velocity by passing through the throttle passage when flowing toward the outflow hole. By adjusting appropriately according to the characteristic of this, the optimal airflow according to the characteristic of a medicinal powder can be formed.

  According to the invention of claim 2, the throttle passage is provided with a valve element that opens during the intake operation.

  With this configuration, when the suction input during the intake operation is weak, the valve element closes the throttle passage. When the suction force becomes strong enough to diffuse the powder, the valve element opens the throttle passage to allow the air flow. Therefore, the medication in a state where the suction input is weak can be restricted, and the medication can be allowed only when the air flow is in a state where the powder can be sufficiently diffused.

  Further, the feature of the configuration adopted by the invention of claim 3 is that a medicine powder reservoir portion for storing medicine powder is provided between the inflow hole and the outflow hole which are drilled through the bulging portion. There is.

  By configuring in this way, the airflow that has flowed into the powder storage part from the inflow hole gradually winds up the powder from the upper side of the powder storage part when it flows toward the outflow hole, and diffuses this powder. Therefore, a small amount of powder can be uniformly dispersed in the air.

  On the other hand, the feature of the configuration adopted by the invention of claim 4 is that the bulging portion is inclined so that the inflow hole side drilled through the bulging portion becomes a shallow bottom portion and the outflow hole side becomes a deep bottom portion. It is in having established.

  By configuring in this way, the powder in the powder container is accumulated around the outflow hole by the inclined surface, so that the airflow flowing from the inflow hole to the outflow hole is the drug collected around the outflow hole. The powder can be discharged at a stretch as if it were extruded.

  Further, the feature of the configuration adopted by the invention of claim 5 is that the bulging portion is inclined so that the inflow hole side drilled through the bulging portion is a deep bottom portion and the outflow hole side is a shallow bottom portion. It is in having established.

  By configuring in this way, the powder in the powder container is accumulated around the inflow hole by the inclined surface, so that the airflow flowing from the inflow hole is directly applied to the powder and the powder The powder can be uniformly dispersed in this air flow.

  As described above, according to the first aspect of the present invention, since the throttle passage is provided between the inflow hole and the outflow hole which are drilled through the bulging portion, the inflow from the inflow hole into the powder container portion When the air flow is directed toward the outflow hole, the flow velocity can be increased by the throttle passage. By adjusting the passage area of the throttle passage according to the characteristics of the powder, it can be adjusted according to the characteristics of the powder. An optimal air flow can be formed. As a result, it is possible to administer a prescribed amount of the powder stored in the powder storage unit to the patient, thereby improving the efficacy of the powder and improving the reliability.

  According to the invention of claim 2, since the valve body that opens during the intake operation is provided in the throttle passage, the throttle passage can be closed by the valve body when the suction input during the intake operation is weak. it can. When the suction force becomes strong enough to diffuse the powder, the valve body can open the throttle passage to allow the air flow to flow. Therefore, it is possible to regulate the medication in a state where the suction input is weak and allow the medication only when the air flow is in a state where the powder can be sufficiently diffused. The drug powder can be administered in a pulsed manner, and the drug powder can be sufficiently diffused to improve the dosing efficiency.

  According to the invention of claim 3, since the medicine powder reservoir for storing the medicine powder is provided between the inflow hole and the outflow hole which are drilled through the bulging portion, When the air flow that has flowed into the powder storage part flows toward the outflow hole, the air flow can gradually roll up the powder from the upper side of the powder storage part and diffuse this powder. It is possible to obtain a state in which the drug powder is uniformly dispersed in the air.

  As a result, it is possible to prevent the powder from flowing all at once and clogging the outflow hole.In addition, even when administering medication to patients with weak trachea, etc. Coughing can be prevented and stable medication can be performed.

  According to the invention of claim 4, since the inflow hole side drilled through the bulge portion is a shallow bottom portion and the outflow hole side is a deep bottom portion in the bulge portion, the inclined surface is provided. Since the powder in the powder container can be collected around the outflow hole by the inclined surface, the powder collected around the outflow hole is pushed out by the airflow flowing from the inflow hole to the outflow hole. It can be drained at once. As a result, the powder stored in the powder storage unit can be inhaled in a short time, and the burden on the patient can be reduced.

  According to the invention of claim 5, the bulging portion is provided with the inclined surface so that the inflow hole side drilled through the bulging portion is a deep bottom portion and the outflow hole side is a shallow bottom portion. Since the powder in the powder container can be accumulated around the inflow hole by the inclined surface, the air flow flowing from the inflow hole can be directly applied to the powder to diffuse the powder. it can. As a result, the medicinal powder can be uniformly dispersed in the entire air flow in the medicinal powder container, and the medicinal powder can be stably supplied little by little.

  Hereinafter, a case where a blister pack according to an embodiment of the present invention is used in an inhalation type dispenser will be described as an example, and will be described in detail with reference to the accompanying drawings.

  First, FIGS. 1 to 12 show a first embodiment of the present invention. First, the configuration of an inhalation-type dispenser applied to this embodiment will be described with reference to FIGS.

  Reference numeral 1 denotes a main body of the inhaler-type prescription device. The main body 1 of the prescription device is roughly constituted by a body 2 and an inhalation port 7 which will be described later.

  Reference numeral 2 denotes a body of the prescription device main body 1, and the body 2 has a cylindrical shape that connects an upper plate portion 4 and a lower plate portion 5, which will be described later, and to which an inhalation port 7 is attached, as shown in FIGS. 3 and 4. The connecting portion 3, a semi-columnar upper plate portion 4 extending in the axial direction from the connecting portion 3, and a semi-columnar shape extending in the axial direction from the connecting portion 3 with a gap below the upper plate portion 4 The lower plate part 5 and a holder mounting groove 6 (described later) formed between the plate parts 4 and 5 are substantially cylindrical as a whole. A female screw 3A into which the suction port 7 is screwed is formed on the inner peripheral side of the connecting portion 3, and a support portion 13 of a drilling tool 12 described later is movably supported on the outer peripheral side of the upper plate portion 4. A drilling tool guide 4A is provided.

  Reference numeral 6 denotes a holder mounting groove provided in the body 2, and the holder mounting groove 6 has a groove inner surface 6 </ b> A on the connecting portion 3 side, a lower surface of the upper plate portion 4 as a ceiling surface 6 </ b> B, and an upper surface of the lower plate portion 5. Is formed as a bottom surface 6C. Thereby, the holder mounting groove 6 is formed to open in three directions, that is, one side in the axial direction, left direction, and right direction. Further, the groove inner surface 6 </ b> A has a concave arc shape corresponding to the outer peripheral shape of the holder 8.

  Further, the holder mounting groove 6 is provided with a central projection 6D which is located approximately at the center of the bottom surface 6C and protrudes upward. The central projection 6D serves as a rotation center of the holder 8 and is formed in a guide groove 8E which will be described later. Engage.

  Reference numeral 7 denotes a suction port attached to the connecting portion 3 of the body 2. The suction port 7 has a male screw 7A formed on the outer periphery on the base end side, and the distal end side is gradually reduced in diameter. Further, a plurality of auxiliary vent holes 7B, 7B,... (Only two are shown) are formed in the radial direction near the proximal end side of the suction port 7, and the auxiliary vent hole 7B is formed in the suction port 7. When breathing in from the outside, the outside air is taken into the suction port 7 to reduce the difficulty of breathing during inhalation. The suction port 7 is attached to the body 2 by screwing the male screw 7 </ b> A to the female screw 3 </ b> A of the connecting portion 3.

  A holder 8 is detachably mounted on the holder mounting groove 6 of the body 2 so as to be rotatable. The holder 8 is formed as a substantially circular plate-like body as shown in FIGS. Further, on the surface side of the holder 8, there are recessed eight fitting recesses 8A, 8A,... Which are located closer to the outer periphery and into which a bulging portion 23 of a blister pack 21 described later is fitted at an interval of 45 degrees in the circumferential direction. Each fitting recess 8A is formed with an inflow side pin hole 8B and an outflow side pin hole 8C penetrating in the thickness direction so as to be separated from each other in the radial direction of the holder 8.

  On the other hand, on the back side of the holder 8, there are eight engagement recesses 8D, 8D,... At 45 degree intervals corresponding to the pin holes 8B, 8C on the inner peripheral side than the pin holes 8B on the inflow side. A spherical body 9B of a positioning mechanism 9 to be described later is engaged with each engaging recess 8D. A guide groove 8E extending in the radial direction from the rotation center of the holder 8 is provided on the back surface side of the holder 8, and the guide groove 8E guides the central protrusion 6D of the holder mounting groove 6 to the rotation center of the holder 8. Is.

  The holder 8 can be rotated in the holder mounting groove 6 by engaging the guide groove 8E with the center projection 6D and inserting it into the holder mounting groove 6 while holding the blister pack 21 to be described later on the surface side. It is attached to.

  Reference numerals 9 and 9 denote positioning mechanisms (see FIG. 5) provided on the body 2. Each positioning mechanism 9 is positioned so as to sandwich the center projection 6D, and is formed on the bottom surface 6C (lower plate portion 5) of the holder mounting groove 6. Consists of a recessed housing hole 9A, a sphere 9B housed in a retaining state in the housing hole 9A, and a coil spring 9C that is located in the housing hole 9A and biases the sphere 9B in the protruding direction. Has been.

  Then, when the positioning mechanism 9 mounts the holder 8 in the holder mounting groove 6 and rotates the holder 8 in this state, the positioning body 9 engages the spherical body 9B with the engaging recess 8D of the holder 8, and each fitting recess One of 8A (powder storage part 25 of the blister pack 21) is positioned at a punching position by a punching tool 12, which will be described later, that is, a dosing position for administering the powder.

  Reference numeral 10 denotes an inflow side air passage provided in the body 2, and the inflow side air passage 10 circulates external air toward the fitting recess 8 </ b> A of the holder 8. The inflow side air passage 10 extends in the upper plate portion 4 in the axial direction, and has one end extending in the axial direction in the lower plate portion 5 and an upper inflow passage 10A having one end opened to the atmosphere at the end face of the upper plate portion 4 and one end. A lower inflow passage 10B whose side is open to the atmosphere side at the end face of the lower plate portion 5, and the upper plate portion 4 and the lower plate portion 5 so as to communicate with the other end of each of the inflow passages 10A and 10B from within the punch guide 4A. The pin insertion hole 10 </ b> C is formed at a position where the pin insertion hole 10 </ b> C can communicate with the pin hole 8 </ b> B of the holder 8.

  Reference numeral 11 denotes an outflow side air passage provided in the body 2, and the outflow side air passage 11 allows the powder in the powder container 25 of the blister pack 21 to flow out toward the suction port 7. The outflow side air passage 11 is connected to the pin insertion hole 11 </ b> A extending in parallel with the pin insertion hole 10 </ b> C of the inflow side air passage 10 so as to communicate with the pin hole 8 </ b> C of the holder 8. One end side extends in the axial direction from one end side to the pin insertion hole 11A and the other end side opens into the suction port 7, and one end side extends from the lower plate portion 5 to the connecting portion 3 in the axial direction. The lower end passage 11 </ b> C communicates with the pin insertion hole 11 </ b> A and has the other end opened into the suction port 7.

  12 is a drilling tool for drilling a blister pack 21 to be described later. As shown in FIG. 1, the drilling tool 12 includes a support portion 13 movably supported in a drilling tool guide 4A, and a base end side of the drilling tool 12. The front end side of the pins 14 and 14 is attached to the support portion 13 and extends into the pin insertion holes 10C and 11A, and the return spring 15 is provided between the support portion 13 and the upper plate portion 4. Yes.

  Here, the drilling tool 12 pushes the support portion 13 against the return spring 15 into the drilling tool guide 4A, and inserts the pins 14 and 14 into the pin insertion holes 10C and 11A. The blister pack 21 is passed through the tip of the inflow hole H1 and the outflow hole H2 in the bulging portion 23 and the cover plate 24 of the bottom plate 22 that define the powder container 25 (see FIGS. 11 and 12 to be described later). In the figure). When the pressing force to the support portion 13 is removed, the support portion 13 and the pins 14 and 14 are retracted to the initial position by the urging force of the return spring 15.

  Next, the blister pack according to the present embodiment used in the inhalation-type dispensing device described above will be described with reference to FIGS.

  Reference numeral 21 denotes a blister pack according to the present embodiment that is detachably attached to an inhalation-type prescription device. The blister pack 21 includes a bottom plate 22, a lid plate 24, a powder container 25, a throttle passage 26, and the like, which will be described later. ing.

  Reference numeral 22 denotes a bottom plate serving as a base of the blister pack 21, and the bottom plate 22 is formed in a thin disk shape using an aluminum material, a resin material, or the like. The bottom plate 22 is provided with a large number of bulging portions 23, 23,... Around the entire circumference, and each bulging portion 23 is located near the outer periphery of the bottom plate 22 and is spaced at 45 degree intervals in the circumferential direction. It is arranged at 8 places.

  Here, as shown in FIGS. 9 and 10, the bulging portion 23 is formed as a bulge extending in the shape of an ellipse in the radial direction of the bottom plate 22, and has substantially hemispherical convex portions 23A at its inner and outer positions. 23B. In addition, between the inner convex portion 23A and the outer convex portion 23B, the inner convex portion 23A and the outer convex portion 23B are connected to each other at a position close to the later-described lid plate 24, whereby the inner convex portion 23A and the outer convex portion 23B are described later. The throttle portion 23 </ b> C forms the throttle passage 26.

  Reference numeral 24 denotes a cover plate attached to the surface of the bottom plate 22, and the cover plate 24 is formed in a thin disk shape using an aluminum material, a resin material, or the like. The lid plate 24 closes each bulging portion 23 formed on the bottom plate 22, thereby defining a later-described drug powder storage portion 25 between the bulging portion 23.

  Reference numeral 25 denotes a medicinal powder container defined between the bulging part 23 and the cover plate 24, and medicinal powder is contained in the medicinal powder container 25. In addition, a narrow passage 26 is formed in the powder container 25 so as to be positioned between an inflow hole H1 and an outflow hole H2 described later.

  A throttle passage 26 is located between the inflow hole H1 and the outflow hole H2 and is formed between the throttle portion 23C of the bulging portion 23 and the cover plate 24. The throttle passage 26 is a medicine powder storage portion 25. By increasing the flow velocity of the airflow flowing from the inflow hole H1 to the outflow hole H2 in the interior or generating an appropriate turbulent flow in the powder storage section 25, the air flow in the powder storage section 25 is changed to the characteristics of the powder. To improve the diffusion of medicinal powder.

  The inhalation-type dispenser and blister pack 21 according to the present embodiment has the above-described configuration. Next, the preparatory operation until the patient inhales the powder and the flow of air and powder during the inhalation are illustrated in FIG. 11 and FIG.

  First, the holder is removed from the holder mounting groove 6 of the body 2. In this case, the guide groove 8 </ b> E formed in the holder 8 can be disposed on the suction port 7 side and removed by pulling out the holder 8 against the positioning mechanism 9.

  Next, the blister pack 21 is disposed on the surface side of the removed holder 8. At this time, each blister pack 21 can be positioned with respect to the holder 8 by fitting each bulging portion 23 (powder container 25) of the blister pack 21 into each fitting recess 8A of the holder 8, and both It can be rotated integrally.

  When the blister pack 21 is thus placed on the holder 8, the holder 8 is mounted in the holder mounting groove 6. In this case, with the guide groove 8E facing the suction port 7, the center protrusion 6D is engaged with the guide groove 8E, and the holder 8 is pushed into the holder mounting groove 6. Then, when the holder 8 is completely pushed in, the spherical body 9B of the positioning mechanism 9 is engaged with the engaging recess 8D of the holder 8 by rotating the holder 8 in an arbitrary direction. Accordingly, one of the powder storage portions 25 of the blister pack 21 can be positioned at a drilling position (drug powder dispensing position) by the drilling tool 12.

  Next, the operation when inhaling medicinal powder will be described. First, the support portion 13 of the drilling tool 12 is pressed in order to make a through hole in the blister pack 21 arranged at the drilling position. As shown in FIGS. 11 and 12, an inflow hole H1 communicating with the inflow side air passage 10 is formed in the bulging portion 23 and the cover plate 24 by the pin 14 on one side, and the bulging portion is formed by the pin 14 on the other side. An outflow hole H2 communicating with the outflow side air passage 11 is formed in 23 and the cover plate 24. As a result, the powder container 25 of the blister pack 21 communicates with the inflow side air passage 10 through the inflow hole H1, and communicates with the outflow side air passage 11 through the outflow hole H2.

  Next, when the patient holds the inhalation port 7 in his / her mouth and inhales in this state, the air flows into the medicinal powder container 25 through the inflow side air passage 10 and the inflow hole H1. At this time, since the air flow flowing from the inflow hole H1 to the outflow hole H2 passes through the throttle passage 26, the throttle passage 26 increases the flow velocity of the air flow and generates an appropriate turbulent flow. The powder can be diffused and atomized. As a result, almost all of the medicinal powder in the medicinal powder container 25 can flow out to the suction port 7 side through the outflow hole H2 and the outflow side air passage 11 together with the air flow. It can be inhaled into the lungs through the patient's mouth and trachea.

  Further, when performing the second dispensing operation, the holder 8 is rotated by 45 degrees, and the spherical body 9B of the positioning mechanism 9 is engaged with the adjacent engaging recess 8D. And by performing the drilling operation | movement and suction | inhalation operation | movement mentioned above, medicinal powder can be continuously inhaled. After eight doses are thus performed, the holder 8 is removed and the blister pack 21 is replaced with a new one.

  As described above, according to the present embodiment, the powder powder storage portion 25 of the blister pack 21 is located between the inflow hole H1 and the outflow hole H2 and is restricted by the constriction portion 23C of the bulging portion 23. 26 is provided, the air flow flowing through the powder container 25 by the throttle passage 26 can be adjusted according to the powder. As a result, the passage area of the squeezing passage 26 depends on the characteristics of the powder to be administered, such as the size of the granules (fine powder, granules, etc.), the cohesive strength, the amount of powder to be administered at one time, etc. By adjusting, an air flow (turbulent flow) corresponding to the medicinal powder can be formed, so that the prescribed amount of medicinal powder accommodated in the medicinal powder accommodating unit 25 can be administered to the patient, Increases efficacy and improves reliability.

  In addition, since the narrowing passage 26 is provided in the blister pack 21 itself that contains the powder, the optimum narrowing passage 26 can be formed for each kind of the powder, and the dosage efficiency can be further improved. it can.

  Next, FIGS. 13 to 16 show a second embodiment of the present invention. The feature of the present embodiment is that a drug powder reservoir for storing drug powder is provided between the inflow hole and the outflow hole that are formed through the bulging portion. In the present embodiment, the same components as those in the first embodiment described above are denoted by the same reference numerals, and the description thereof is omitted.

  31 is a blister pack according to the present embodiment used in place of the blister pack 21 according to the first embodiment. The blister pack 31 includes a bottom plate 32, a drug powder reservoir 34, a lid plate 35, and a drug powder, which will be described later. It is comprised by the accommodating part 36 grade | etc.,.

  Reference numeral 32 denotes a bottom plate according to the present embodiment which becomes a base of the blister pack 31. The bottom plate 32 is a thin circle made of an aluminum material, a resin material, or the like in substantially the same manner as the bottom plate 22 according to the first embodiment described above. It is formed in a plate shape, and a large number of bulging portions 33, 33,... Are provided over the entire circumference. However, the bottom plate 32 according to this embodiment is different from the bottom plate 22 according to the first embodiment in that the shape of each bulging portion 33 is different from the bulging portion 23 according to the first embodiment. .

  Here, as shown in FIG. 14, the bulging portion 33 is formed as, for example, a bulge extending in the shape of an ellipse in the radial direction of the bottom plate 32, and a shallow hole 33A in which an inflow hole H1 is formed at an inner position thereof. Is formed, and a shallow hole 33B in which the outflow hole H2 is formed is formed at the outer position. Further, the bulging portion 33 is provided with a drug powder reservoir portion 34 which will be described later, located between the perforating portions 33A and 33B.

  Reference numeral 34 denotes a powder reservoir as an air flow adjusting means provided in the bulging portion 33. The drug reservoir 34 includes a hole 33A where an inflow hole H1 is opened and a hole 33B where an outflow hole H2 is opened. It is located between and formed in the deep bottom, and medicinal powder is accumulated.

  On the other hand, 35 is a lid plate attached to the surface of the bottom plate 32. The lid plate 35 is made of a thin wall using an aluminum material, a resin material or the like, similar to the lid plate 24 described in the first embodiment. It is formed in a disc shape.

  Reference numeral 36 denotes a medicinal powder container defined between the bulging portion 33 and the lid plate 35. The medicinal powder is accommodated in the medicinal powder container 36, and a part of the medicinal powder is medicinal powder. It collects in the reservoir 34.

  The blister pack 31 according to the present embodiment has the above-described configuration. Next, the flow of air and powder in the powder container 36 during the intake operation will be described with reference to FIGS. 15 and 16.

  First, when an inflow hole H1 and an outflow hole H2 are formed in the blister pack 31 and air is sucked in through the suction port 7, at the beginning of the intake operation, as shown in FIG. Rolls up the powder located on the upper side of the powder reservoir 34, diffuses it, and supplies it to the outflow hole H2. Further, when the intake operation is repeated several times, the powder in the powder container 36 gradually decreases. At this time, as shown in FIG. 16, the air flow flowing from the inflow hole H1 enters the powder reservoir 34, and the powder in the drug reservoir 34 is gradually rolled up from the upper side and diffused to flow out. It can be supplied to the H2 side.

  Thus, according to the present embodiment, since the powder stored in the powder storage unit 36 can be wound up little by little and spread uniformly, the situation where the powder flows at once and the outflow hole H2 is clogged. Can be prevented. In addition, when the drug is administered to a patient with a weak trachea or the like, the powder can be sucked in a small amount, so that coughing at the time of the drug can be prevented and stable drug administration can be performed.

  Next, FIGS. 17 to 20 show a third embodiment of the present invention. The feature of this embodiment is that the bulging portion is provided with an inclined surface so that the inflow hole side penetrating through the bulging portion is a shallow bottom portion and the outflow hole side is a deep bottom portion. In the present embodiment, the same components as those in the first embodiment described above are denoted by the same reference numerals, and the description thereof is omitted.

  Reference numeral 41 denotes a blister pack according to the present embodiment used in place of the blister pack 21 according to the first embodiment. The blister pack 41 includes a bottom plate 42, an inclined surface 44, a lid plate 45, and a medicine powder container, which will be described later. It is comprised by the part 46 grade | etc.,.

  Reference numeral 42 denotes a bottom plate according to the present embodiment which becomes a base of the blister pack 41. The bottom plate 42 is a thin circular plate made of an aluminum material, a resin material or the like in substantially the same manner as the bottom plate 22 according to the first embodiment described above. It is formed in a plate shape, and a large number of bulging portions 43, 43,... Are provided over the entire circumference. However, the bottom plate 42 according to the present embodiment is different from the bottom plate 22 according to the first embodiment in that the shape of each bulging portion 43 is different from the bulging portion 23 according to the first embodiment. .

  Here, as shown in FIG. 18, the bulging portion 43 is formed, for example, as an elliptical bulge extending in the radial direction of the bottom plate 42, and the inner position thereof, that is, the position where the inflow hole H1 is opened is an inclined surface 44 described later. The outer position, that is, the position where the outflow hole H2 is formed is formed in the deep bottom.

  44 is an inclined surface provided in the bulging portion 43, and the inclined surface 44 faces downward so that the bulging of the bulging portion 43 increases from the inner side on the inflow hole H1 side toward the outer side on the outflow hole H2 side. It is formed to be inclined.

  On the other hand, 45 is a cover plate affixed to the surface of the bottom plate 42, and the cover plate 45 is made of a thin wall using an aluminum material, a resin material, or the like, similar to the cover plate 24 described in the first embodiment. It is formed in a disc shape.

  Reference numeral 46 denotes a medicinal powder container defined between the bulging portion 43 and the cover plate 45. The medicinal powder is accommodated in the medicinal powder container 46, and the medicinal powder flows out by the inclined surface 44. It collects on the hole H2 side.

  The blister pack 41 according to the present embodiment has the above-described configuration. Next, the flow of air and powder in the powder container 46 during the intake operation will be described with reference to FIGS. 19 and 20.

  First, when an inflow hole H1 and an outflow hole H2 are formed in the blister pack 41 and air is sucked through the suction port 7, at the beginning of the suction operation, as shown in FIG. However, while the powder in the powder container 46 is diffused, it moves so as to push the powder toward the outflow hole H2. Then, as shown in FIG. 20, the air flow flowing in from the inflow hole H1 can flow out from the outflow hole H2 at a stretch so as to push out the powder in the powder container 46.

  Thus, according to the present embodiment, the powder that has moved to the periphery of the outflow hole H2 by the airflow flowing from the inflow hole H1 to the outflow hole H2 can be discharged at once. As a result, since the patient can inhale the powder stored in the powder storage unit 46 in a short time, the burden on the patient can be reduced. Moreover, this embodiment is suitable for administration of a small amount of drug powder.

  Next, FIGS. 21 to 24 show a fourth embodiment of the present invention. The feature of this embodiment is that the bulging portion is provided with an inclined surface so that the inflow hole side penetrating through the bulging portion is a deep bottom portion and the outflow hole side is a shallow bottom portion. In the present embodiment, the same components as those in the first embodiment described above are denoted by the same reference numerals, and the description thereof is omitted.

  Reference numeral 51 denotes a blister pack according to the present embodiment used in place of the blister pack 21 according to the first embodiment. The blister pack 51 includes a bottom plate 52, an inclined surface 54, a cover plate 55, and a powder container, which will be described later. 56 or the like.

  Reference numeral 52 denotes a bottom plate according to the present embodiment which becomes a base of the blister pack 51. The bottom plate 52 is a thin circular plate made of an aluminum material, a resin material, or the like in substantially the same manner as the bottom plate 22 according to the first embodiment described above. It forms in plate shape and many bulging parts 53, 53, ... are provided over the perimeter. However, the bottom plate 52 according to this embodiment is different from the bottom plate 22 according to the first embodiment in that the shape of each bulging portion 53 is different from the bulging portion 23 according to the first embodiment. .

  Here, as shown in FIG. 22, the bulging portion 53 is formed as, for example, an elliptical bulge extending in the radial direction of the bottom plate 52, and an inner position thereof, that is, a position where the inflow hole H1 is opened is an inclined surface 54 described later. The outer position, that is, the position where the outflow hole H2 is formed is formed in the shallow bottom.

  54 is an inclined surface provided in the bulging portion 43, and the inclined surface 54 faces upward so that the bulging of the bulging portion 43 decreases from the inner side on the inflow hole H1 side toward the outer side on the outflow hole H2 side. It is formed to be inclined.

  On the other hand, 55 is a cover plate affixed to the surface of the bottom plate 52. The cover plate 55 is made of a thin wall using an aluminum material, a resin material or the like, similar to the cover plate 24 described in the first embodiment. It is formed in a disc shape.

  Reference numeral 56 denotes a medicinal powder container defined between the bulging portion 53 and the cover plate 55. The medicinal powder is accommodated in the medicinal powder container 56, and the medicinal powder flows into the inclined surface 54. It collects on the hole H1 side.

  The blister pack 51 according to the present embodiment has the above-described configuration. When an inflow hole H1 and an outflow hole H2 are formed in the blister pack 51 and air is sucked through the suction port 7, the intake operation is started at the beginning. As shown in FIG. 23, the air flow flowing in from the inflow hole H1 directly hits the powder collected on the inflow hole H1 side and diffuses at once. As a result, the airflow flowing in from the inflow hole H1 can gradually flow out of the powder diffused in the powder container 56 from the outflow hole H2, as shown in FIG.

  Thus, according to the present embodiment, since the powder can be diffused by directly applying the air flow flowing in from the inflow hole H1 to the powder, the powder is diffused in the powder container 56. Can be uniformly dispersed in the air, and the powder can be stably supplied to the patient little by little.

  Next, FIG. 25 shows a fifth embodiment of the present invention. A feature of the present embodiment is that a throttle passage is provided between an inflow hole and an outflow hole that penetrate through the bulging portion, and a valve body that opens during intake operation is provided in the throttle passage. It is in. In the present embodiment, the same components as those in the first embodiment described above are denoted by the same reference numerals, and the description thereof is omitted.

  Reference numeral 61 denotes a blister pack according to the present embodiment used in place of the blister pack 21 according to the first embodiment. The blister pack 61 includes a bottom plate 62, a cover plate 64, a powder container 65, a throttle passage, which will be described later. 66, a flap valve 67, and the like.

  Reference numeral 62 denotes a bottom plate according to the present embodiment, which becomes the base of the blister pack 61. The bottom plate 62 is a thin circular plate made of an aluminum material, a resin material, or the like in substantially the same manner as the bottom plate 22 according to the first embodiment described above. It is formed in a plate shape, and a large number of bulging portions 63, 63,... Are provided over the entire circumference. Further, the bulging portion 63 has an inner convex portion 63A and an outer convex portion 63B, and a constricted portion 63C is formed between the convex portions 63A and 63B.

  On the other hand, 64 is a cover plate affixed to the surface of the bottom plate 62. The cover plate 64 is made of an aluminum material, a resin material, or the like in substantially the same manner as the cover plate 24 described in the first embodiment. It is formed in a thin disk shape. However, the lid plate 64 is different from the lid plate 24 according to the first embodiment in that a flap valve 67 for opening and closing a throttle passage 66 described later is provided.

  Reference numeral 65 denotes a chemical powder container defined between the bulging part 63 and the cover plate 64, and the chemical powder is stored in the chemical powder container 65.

  Further, 66 is formed between the inflow hole H1 and the outflow hole H2 formed in the same manner as in the first embodiment, and is formed between the throttle part 63C of the bulging part 63 and the cover plate 64. The throttle passage 67 is a flap valve as a valve body provided on the lid plate 64 so as to open and close the throttle passage 66. The flap valve 67 is shown in FIG. The throttle passage 66 is closed as indicated by the solid line. When the suction input becomes strong enough to diffuse the powder, the throttle passage 66 is opened to allow the air flow to flow as shown by the two-dot chain line.

  Thus, according to the present embodiment, it is possible to regulate the dosing in the state where the suction input is weak by the flap valve 67, and allow the dosing only when the air flow is in a state where the powder can be sufficiently diffused. Can do. Furthermore, the powder can be administered intermittently (pulse-like) in accordance with the strength of the suction input. Thereby, a medicinal powder can fully be spread | diffused and dosing efficiency can be improved.

  In the first embodiment, the blister pack 21 has been described by taking as an example the case where eight bulging portions 23 (drug powder storage portions 25) are provided in the circumferential direction. For example, a blister pack in which 2 or more, less than 7 or 9 or more bulging portions are provided may be used. In this case, the number of fitting recesses 8A, pin holes 8B and 8C, and engagement recesses 8D of the holder 8 may be made to correspond to the number of bulging portions. This configuration can also be applied to the second to fifth embodiments.

  In the first embodiment, the case where the bulging portion 23 is formed as an oval bulge extending in the radial direction of the bottom plate 22 has been described as an example. However, the present invention is not limited to this example. As in the modification shown in Fig. 26, the bulging portion 23 'may be formed in a bowl shape. In this case, the passage area of the throttle passage can be reduced, and the flow velocity of the air flow can be further increased.

It is a longitudinal cross-sectional view which shows the inhalation-type dosing device applied to the 1st Embodiment of this invention. It is a top view which shows an inhalation type dispenser. It is a longitudinal cross-sectional view which shows the body in FIG. 1 alone. It is the longitudinal cross-sectional view which looked at the body from the arrow IV-IV direction in FIG. It is the cross-sectional view which looked at the body and the positioning mechanism from the arrow VV direction in FIG. It is a top view which shows a holder alone. It is a bottom view which shows a holder alone. It is the external appearance perspective view which looked at the blister pack by the 1st Embodiment of this invention from the bottom part side. It is a bottom view which shows a bulging part alone. It is a principal part expanded longitudinal cross-sectional view which shows a bulging part, a chemical | medical agent powder storage part, an aperture | diaphragm | restriction channel | path part, etc. It is a longitudinal cross-sectional view which shows the inhalation-type dosing device of the state which is inhaling the powder in the powder storage part of a blister pack. It is a principal part expanded longitudinal cross-sectional view in FIG. 11 which shows the flow of the air and the powder in the powder storage part of a blister pack. It is the external appearance perspective view which looked at the blister pack by the 2nd Embodiment of this invention from the bottom part side. It is a principal part expanded longitudinal cross-sectional view which shows the bulging part in FIG. 13, a chemical | medical agent powder storage part, a chemical | medical agent powder storage part, etc. FIG. It is a principal part expanded longitudinal cross-sectional view of the blister pack which shows the air flow and the flow of a chemical | drug | medicine in a chemical | medical powder storage part when an inhalation operation is started. It is a principal part expanded longitudinal cross-sectional view of the blister pack which shows the air flow and the flow of a powder in the powder storage part in the middle of inhalation operation | movement. It is the external appearance perspective view which looked at the blister pack by the 3rd Embodiment of this invention from the bottom part side. FIG. 18 is an enlarged vertical sectional view of a main part showing a bulging part, a powder container, an inclined surface, etc. in FIG. 17. It is a principal part expanded longitudinal cross-sectional view of the blister pack which shows the air flow and the flow of a chemical | drug | medicine in a chemical | medical powder storage part when an inhalation operation is started. It is a principal part expanded longitudinal cross-sectional view of the blister pack which shows the air flow and the flow of a powder in the powder storage part in the middle of inhalation operation | movement. It is the external appearance perspective view which looked at the blister pack by the 4th Embodiment of this invention from the bottom part side. It is a principal part expanded longitudinal cross-sectional view which shows the bulging part in FIG. 21, a chemical | medical agent powder storage part, an inclined surface, etc. FIG. It is a principal part expanded longitudinal cross-sectional view of the blister pack which shows the air flow and the flow of a chemical | drug | medicine in a chemical | medical powder storage part when an inhalation operation is started. It is a principal part expanded longitudinal cross-sectional view of the blister pack which shows the air flow and the flow of a powder in the powder storage part in the middle of inhalation operation | movement. It is a principal part expanded longitudinal cross-sectional view which shows the bulging part of the blister pack by the 5th Embodiment of this invention, a cover board, a chemical | drug | medicine powder accommodating part, a throttle channel, a flap valve, etc. It is a bottom view which shows the bulging part by the modification of this invention alone.

Explanation of symbols

21, 31, 41, 51, 61 Blister pack 22, 32, 42, 52, 62 Bottom plate 23, 33, 43, 53, 63, 23 'Swelling portion 24, 35, 45, 55, 64 Lid plate 25, 36 , 46, 56, 65 Powder storage part 26, 66 Restriction passage 34 Powder storage part 44, 54 Inclined surface 67 Flap valve (valve)
H1 inflow hole H2 outflow hole

Claims (5)

  In a blister pack comprising a bottom plate formed with a bulging portion and a lid plate provided on the surface side of the bottom plate and closing the bulging portion to define a powder container, the penetrating through the bulging portion A blister pack, characterized in that a throttle passage is provided between an inflow hole and an outflow hole that are perforated.   The blister pack according to claim 1, wherein the throttle passage is provided with a valve body that opens during intake operation.   In a blister pack comprising a bottom plate formed with a bulging portion and a lid plate provided on the surface side of the bottom plate and closing the bulging portion to define a powder container, the penetrating through the bulging portion A blister pack characterized in that a drug powder reservoir for storing drug powder is provided between an inflow hole and an outflow hole that are perforated.   In a blister pack comprising a bottom plate on which a bulging portion is formed and a lid plate that is provided on the surface side of the bottom plate and closes the bulging portion to define a powder container, the bulging portion includes A blister pack characterized in that an inclined surface is provided so that an inflow hole side penetrating through a bulging portion is a shallow bottom portion and an outflow hole side is a deep bottom portion.   In a blister pack comprising a bottom plate on which a bulging portion is formed and a lid plate that is provided on the surface side of the bottom plate and closes the bulging portion to define a powder container, the bulging portion includes A blister pack characterized in that an inclined surface is provided so that the inflow hole side penetrating through the bulging portion is a deep bottom portion and the outflow hole side is a shallow bottom portion.

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