JP2006136313A - Medicine-volatilizing device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a type of a medicine-volatilizing device, exhibiting a stable medicine-volatilizing performance and also equipped with a simple and easy to use displaying function of a residual medicine. <P>SOLUTION: In this medicine-volatilizing device 1 volatilizing the medicine from a medicine carrier based on wind power by a fan to the medicine carrier consisting of the medicine loaded on a carrier, the carrier is a sublimating material or gel-forming material so as to be able to recognize the end point of the volatilization of the medicine by viewing the disappearance of the medicine carrier 2 accompanying with the progression of use of the device. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

The present invention relates to an improvement of a chemical volatilization device of a type in which a chemical carrier is volatilized based on wind power generated by a fan.

Mosquito coil that uses thermal energy as a chemical volatilization method that volatilizes and releases chemicals in the entire enclosed space (indoors, car interiors, outdoor sports tents, etc.) to eliminate pests such as mosquitoes and moths In general, an electric mosquito mat and a liquid electric mosquito trap (liquid) are generally used, but a method of volatilizing and releasing the drug using wind power such as a fan at room temperature has been put into practical use. The latter method does not necessarily require an AC power supply and can be carried, and is therefore useful for carrying. The present inventors also disclosed in JP-A-2001-247406 that a cartridge for storing a drug-impregnated body is a motor. Disclosed is a method for volatilizing and releasing a drug by rotating and releasing the drug more efficiently.

However, conventional fan-type chemical volatilization devices, including those disclosed in Japanese Patent Application Laid-Open No. 2001-247406, cannot be said to be sufficiently satisfactory in the function of informing the expiration date of the cartridge containing the drug-impregnated body. For example, there is a method of using a color change by adding a pigment that is linked to the amount of active ingredient to the drug impregnated body, but the end point is unclear, and the expiration date of the cartridge and the life of the dry battery are set to be the same Even with this method, it is difficult to design a simple system because of the wide range of battery performance.
Recently, a product using a liquid crystal display is commercially available. However, since an electric control mechanism is required, the apparatus is complicated and the cost is inevitably increased.

By the way, some proposals using a sublimable substance or a gel former as an indicator for displaying the amount of remaining medicine are known. For example, in JP-A-7-149601, a tablet in which a room temperature volatile insect repellent and a sublimation substance are combined is housed in a packaging container made of a breathable material. It is described that the remaining state can be recognized. Similarly, JP-A-63-222104 discloses a gel type insect repellent in which a room temperature volatile insect repellent and a gel former are combined.
However, these proposed insect repellents have a problem that when used by standing with a chiffon or the like, the disappearance of the sublimable substance or the gel-forming body is significantly influenced by environmental conditions such as the temperature. For this reason, as for the application to the indicator of a sublimable substance or a gel formation body, it is the present condition that the clear end-point display is not requested | required but the insecticide.
JP 2001-247406 A Japanese Patent Laid-Open No. 7-149601 JP 63-222104 A

An object of this invention is to provide the chemical | medical agent volatilization device of the type which had stable chemical | medical agent volatilization performance, and was equipped with the simple and easy-to-use chemical residual amount display function.

（式中、Ｘは水素原子又はメチル基を表す。Ｘが水素原子の時、Ｙはビニル基、１−プロペニル基、２−メチル−１−プロペニル基、２，２−ジクロロビニル基、２，２−ジフルオロビニル基又は２−クロロ−２−トリフルオロメチルビニル基を表し、Ｘがメチル基の時、Ｙはメチル基を表す。また、Ｚは水素原子、フッ素原子、メチル基、メトキシメチル基又はプロパルギル基を表す）で表されるフッ素置換ベンジルアルコールエステル化合物から選ばれた１種又は２種である（１）ないし（５）のいずれか記載の薬剤揮散装置。 In order to solve the above problems, the present invention employs the following configuration.
(1) In a drug volatilization apparatus that volatilizes the drug from the drug carrier based on wind power generated by a fan against a drug carrier formed by supporting the drug on a carrier, the carrier is a sublimable substance or a gel former. The chemical volatilization apparatus which can recognize the volatilization end point of the chemical | medical agent by visually observing the disappearance state of the chemical | medical agent carrier accompanying use progress.
(2) The chemical volatilization device according to (1), wherein the sublimable substance is 2,4,6-triisopropyl-1,3,5-trioxane or adamantane.
(3) The chemical volatilization device according to (1), wherein the gel former includes an N-acylamino acid derivative-based gelling agent.
(4) The drug carrier is housed in a flexible bag formed of breathable paper or non-woven fabric, and at least a part of the drug carrier is flexible even if the drug carrier shrinks over time. The chemical volatilization device according to any one of (1) to (3), which is configured to be in contact with the inner surface of the paper or the nonwoven fabric of the sex bag.
(5) The drug volatilization apparatus according to any one of (1) to (3), wherein the drug carrier is housed in a plastic molded body having a vent hole.
(6) The drug is represented by the general formula (I)

(Wherein X represents a hydrogen atom or a methyl group. When X is a hydrogen atom, Y represents a vinyl group, 1-propenyl group, 2-methyl-1-propenyl group, 2,2-dichlorovinyl group, 2, Represents a 2-difluorovinyl group or 2-chloro-2-trifluoromethylvinyl group, and when X is a methyl group, Y represents a methyl group, and Z represents a hydrogen atom, a fluorine atom, a methyl group, or a methoxymethyl group. (Or represents a propargyl group) The drug volatilization device according to any one of (1) to (5), which is one or two selected from fluorine-substituted benzyl alcohol ester compounds represented by:

The chemical volatilization apparatus of the present invention is a type that volatilizes a chemical from a chemical carrier based on wind power generated by a fan. The chemical is volatilized efficiently and exhibits an excellent insecticidal effect, and a simple and easy-to-use chemical residue. Since it has a quantity display function, its practicality is extremely high.

（式中、Ｘは水素原子又はメチル基を表す。Ｘが水素原子の時、Ｙはビニル基、１−プロペニル基、２−メチル−１−プロペニル基、２，２−ジクロロビニル基、２，２−ジフルオロビニル基又は２−クロロ−２−トリフルオロメチルビニル基を表し、Ｘがメチル基の時、Ｙはメチル基を表す。また、Ｚは水素原子、フッ素原子、メチル基、メトキシメチル基又はプロパルギル基を表す）で表されるフッ素置換ベンジルアルコールエステル化合物から選ばれた常温揮散性殺虫成分が好適である。これらの化合物は、従来のアレスリン、フラメトリン及びプラレトリンに比べて蒸気圧が高く、蚊、ハエ、ブユ、ユスリカなどの害虫に対する殺虫効力も優れている。なお、化合物の酸成分において、不斉炭素に基づく光学異性体や幾何異性体が存在する場合、それらの各々や任意の混合物も本発明に包含されることはもちろんである。 Examples of the drug used in the present invention include an insecticidal component, acaricidal component, repellent component, antibacterial component, deodorant component, aroma component and the like having excellent volatility. Insecticidal components include empentrin and tephrametrin, especially the general formula (I)

(Wherein X represents a hydrogen atom or a methyl group. When X is a hydrogen atom, Y represents a vinyl group, 1-propenyl group, 2-methyl-1-propenyl group, 2,2-dichlorovinyl group, 2, Represents a 2-difluorovinyl group or 2-chloro-2-trifluoromethylvinyl group, and when X is a methyl group, Y represents a methyl group, and Z represents a hydrogen atom, a fluorine atom, a methyl group, or a methoxymethyl group. Or, a room temperature volatile insecticidal component selected from fluorine-substituted benzyl alcohol ester compounds represented by the formula: These compounds have a higher vapor pressure than conventional allethrin, framethrin, and praretrin, and are excellent in insecticidal activity against pests such as mosquitoes, flies, flyfish, chironomids. In addition, when the optical component and geometrical isomer based on an asymmetric carbon exist in the acid component of a compound, it is needless to say that each and arbitrary mixtures thereof are also included in the present invention.

Specific examples of the compound represented by the general formula (I) include 2,3,5,6-tetrafluorobenzyl-chrysanthemate (hereinafter referred to as Compound A), 2,3,5,6-tetrafluoro. Benzyl-2,2-dimethyl-3- (1-propenyl) cyclopropanecarboxylate (hereinafter referred to as Compound B), 2,3,5,6-tetrafluorobenzyl-2,2-dimethyl-3- (2 , 2-dichlorovinyl) cyclopropanecarboxylate (hereinafter referred to as Compound C), 4-methyl-2,3,5,6-tetrafluorobenzyl-chrysantemate (hereinafter referred to as Compound D), 4-methyl -2,3,5,6-tetrafluorobenzyl-2,2-dimethyl-3- (1-propenyl) cyclopropanecarboxylate (hereinafter referred to as Compound E), 4-methyl-2, , 5,6-tetrafluorobenzyl-2,2-dimethyl-3- (2,2-difluorovinyl) cyclopropanecarboxylate (hereinafter referred to as Compound F), 4-methoxymethyl-2,3,5,6 -Tetrafluorobenzyl-chrysanthemate (hereinafter referred to as compound G), 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl-2,2-dimethyl-3- (1-propenyl) cyclopropanecarboxy Rate (hereinafter referred to as Compound H), 2,3,4,5,6-pentafluorobenzyl-2,2-dimethyl-3- (2-chloro-2-trifluoromethylvinyl) cyclopropanecarboxylate (hereinafter referred to as Compound H) 4-propargyl-2,3,5,6-tetrafluorobenzyl-2,2-dimethyl-3- (1-propenyl) Lopropanecarboxylate (hereinafter referred to as Compound J), 4-methyl-2,3,5,6-tetrafluorobenzyl-2,2-dimethyl-3-vinylcyclopropanecarboxylate (hereinafter referred to as Compound K) 2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (hereinafter referred to as Compound L), or 4-methoxymethyl-2,3,5,6- Examples thereof include tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (hereinafter referred to as compound M).

Examples of other drugs include repellent components such as diet, dimethyl phthalate, 2-ethyl-1,3-hexanediol, antibacterial components such as hinokitiol, tetrahydrolinalol, eugenol, citronellal, allyl isothiocyanate, citronella oil, Orange oil, lemon oil, lime oil, yuzu oil, lavender oil, peppermint oil, eucalyptus oil, jasmine oil, camellia oil, green tea essential oil, limonene, α-pinene, linalool, geraniol, phenylethyl alcohol, amylcinnamic aldehyde, Examples include aromatic components such as cuminaldehyde and benzyl acetate, green leaf alcohol called “green fragrance”, and flavor components containing green leaf aldehyde.

The present invention is characterized in that a sublimable substance or a gel former is used as the carrier for the drug. This is a new finding of the present inventors, that is, the disappearance rate of the sublimable substance or the gel former in the stationary state is largely influenced by the environmental conditions and is not stable, but under the situation where the wind force by the fan acts, The sublimable substance or gel former is based on the test result that disappears at a substantially constant rate with the volatilization of the drug.

Examples of sublimable substances include 2,4,6-triisopropyl-1,3,5-trioxane [trade name: Sunsaburi (manufactured by Ogawa Fragrance Co., Ltd.)], adamantane, tricyclododecane [trade name: Aisawa D (Idemitsu Oil Co., Ltd.). Chemical Co., Ltd.)], 2-hydroxycamphor (common name: borneol), 2,2-dimethyl-1,3-propanediol (common name: neopentyl glycol), among others, 2,4 , 6-Triisopropyl-1,3,5-trioxane and adamantane are easy to use.

The shape of the sublimable substance is arbitrary, but tablets formed into a plate shape, a rod shape, a disk shape, a donut shape, etc. are common. Moreover, 20-150 mg, Preferably 30-80 mg is suitable for the chemical | medical agent load with respect to a sublimable substance (usually 0.5-5g, Preferably 1-3g). When the amount of the drug supported is less than 20 mg, the sustainability of the efficacy (particularly insecticidal efficacy) may be insufficient. On the other hand, the maximum amount of the supported amount is preferably 150 mg or less in consideration of the liquid absorption capacity of the carrier. .
When the drug is supported, the sublimable substance after molding may be impregnated with a solvent, surfactant, dispersant, etc., if necessary, or a mixture of the drug and sublimable substance is melted and cooled. Or it can be formed into a tablet using a pressurizer.

On the other hand, examples of the gel former include those formed using a gelling agent such as an N-acylamino acid derivative gelling agent, an aluminum salt of 2-ethylhexanoic acid, 12-hydroxystearic acid, etc. From the viewpoints of properties, shape retention, and volatility of drugs, a type containing an N-acylamino acid derivative-based gelling agent is preferable.
N-acyl amino acid derivative-based gelling agents include N-acyl amino acid esters, N-acyl amino acid amides, and N-acyl amino acid amine salts. For example, N-lauroyl-L-glutamic acid-α, γ-di- n-Butylamide [manufactured by Ajinomoto Co., Inc., trade name: oil gelling agent GP-1] (hereinafter referred to as gelling agent A) is highly safe and easy to use.

As the solvent used together with the gelling agent A, paraffinic or aromatic hydrocarbons, aliphatic or aromatic esters and the like can be used. For example, Deotomisol S, Neothiozol S, Chuo Kasei Co., Ltd., Sorbet H, Nippon Petrochemical Co., Ltd., SH-NP, Nikko Petrochemical Co., Ltd., IP Solvent, Idemitsu Petrochemical Co., Ltd. -2835, a paraffinic solvent having 13 to 16 carbon atoms such as Isopar V manufactured by Exxon Chemical Co., Ltd., and lower alkyl esters such as phthalic acid, fumaric acid, maleic acid, or adipic acid.
The mixing ratio of each component in the drug carrier using the gelling agent A is suitably 0.1 to 10 parts by weight of the gelling agent A and 10 to 50 parts by weight of the solvent per 1 part by weight of the drug. The drug carrier is added with a predetermined amount of gelling agent A to the solvent, heated and dissolved at a temperature equal to or higher than the dissolution temperature (about 70 to 150 ° C.), then added with a predetermined amount of the drug and allowed to cool by standing. Easy to prepare.

In the drug carrier used in the present invention, a stabilizer, a fragrance, a colorant, an antistatic agent and the like may be appropriately blended. The addition of color is particularly preferable because it not only increases the commercial value but also makes it possible to clearly see the volatilization end point of the drug.

The present invention makes it possible to recognize the volatilization end point of the drug, that is, the use end point of the drug carrier, and the usage time of the drug volatilization device by visually observing the disappearance state of the sublimable substance or the gel former. Since an electric control mechanism such as a liquid crystal display is not required, it is inexpensive and easy to use, and the usage time of the chemical volatilization device can be notified almost accurately.

In the present invention, a substance other than the sublimable substance or the gel former can be used as a part of the carrier. Examples thereof include cellulosic carriers such as paper, pulp and viscose, synthetic resin carriers such as ethylene-vinyl acetate resin, polyester and olefin polymer, and inorganic carriers such as calcium silicate. However, these carriers are involved only in the volatilization of the drug, and the display function is of course left to the sublimable substance or the gel former.

In order to prevent the drug carrier from being dissipated when it is crushed or to adjust the disappearance rate of the sublimation substance or gel former, it is preferable to use the drug carrier in a suitable container. And) a flexible bag formed of breathable paper or non-woven fabric, and (2) a plastic molded body having a vent hole.

In the flexible bag (1), at least a part of the flexible bag is in contact with the inner surface of the paper or the nonwoven fabric of the flexible bag even when the drug carrier shrinks with the progress of use. That is, the drug exuded on the surface of the sublimable substance or gel-forming body as a carrier migrates and diffuses to a breathable paper or nonwoven fabric, and the volatilization of the drug and the disappearance of the drug carrier proceed in parallel. .
As the material of paper or nonwoven fabric, natural paper, semi-synthetic fiber such as rayon, such as Japanese paper, pulp paper, polyolefin such as polyethylene (PE), polypropylene (PP), or drug adsorbent such as ethylene-vinyl acetate (EVA) The synthetic fibers are not limited to these.

Here, the paper or nonwoven fabric preferably has a basis weight of about 10 to 60 g / m ² . If the weight per unit area is too large, it becomes difficult to control the volatilization of the drug, and the flexibility is impaired, and the opacity increases and it is difficult to visually recognize the disappearance of the drug carrier from the outside.
Further, the paper or the nonwoven fabric is not limited to a single material, and for example, a blended material in which polypropylene is mixed with rayon may be used to impart sealing properties.

In addition, the plastic molded body having the air holes of (2) includes a bag body, an integrally molded body, and a part in which a film or a nonwoven fabric is bonded to an opening.
Examples of the plastic material include, but are not limited to, polyesters such as polyethylene terephthalate (PET) and polybutylene terephthalate (PBT), polyamide (PA), polyacetal, polycarbonate, methylpentene polymer, polyethylene, and polypropylene. As long as the volatility of the drug is ensured, non-adsorptive ones such as polyester and polyamide are preferable. For example, polyethylene or polypropylene may be used as a sealant for a film or nonwoven fabric.

In the present invention, in order to stably hold the drug carrier, the upper and lower side surfaces of the drug carrier housed in a flexible bag or a plastic molded body are respectively surrounded by the upper and lower parts, and a plurality of outer peripheries are provided. You may accommodate in the cartridge enclosed by the holding frame.
The shape and size of the cartridge can also be arbitrarily determined, and examples thereof include a disk-shaped, cage-shaped, or annular hollow structure having a rectangular cross section. In addition, the shape and number of the holding frames are not particularly limited, but in consideration of design convenience, for example, the upper and lower surfaces are plate-shaped and the periphery has a round shape, a triangular shape, or a rectangular shape. It is appropriate to provide a plurality of items.

The drug volatilization device of the present invention volatilizes the drug from the drug carrier using wind power generated by a fan. The shape of the fan is not particularly limited, but an axial fan or a sirocco fan is suitable. ing.
Further, a protective bar such as a slit shape or a mesh shape may be attached to a part of the chemical volatilization device so that fingers during use do not touch the chemical carrier.

The specification of the motor used for driving the fan in the present invention is suitable for driving at 1.5 to 6.0 V DC and giving a rotational speed of 200 to 2000 rpm. Further, as the power source, dry cell driving is preferable because of the simplification of the apparatus, but it can be shared with a 100V AC power source or can be configured using a solar cell. When using a 100V AC power supply, the voltage is dropped and rectified using an AC adapter, and then supplied to the motor power supply circuit. The AC adapter may be built in the chemical volatilization apparatus, but if it is integrated with the outlet plug, there is an advantage that the power cord between the plug and the chemical volatilization apparatus can be reduced in weight.

The present invention is that the disappearance rate of the sublimable substance or the gel-forming body when the drug carrier is placed under the condition where the wind force from the fan acts is much higher and more stable than the disappearance rate in the stationary state. It is used. That is, since the disappearance speed of the sublimable substance or gel former is almost proportional to the driving period of the fan, the end point of use of the chemical volatilization apparatus can be notified by the disappearance of the sublimable substance or gel former. In addition, the disappearance rate of the sublimable substance or gel formed body is adjusted by changing the air permeability of the flexible bag or the plastic molded body, or by dividing the drug carrier into several parts and changing the surface area thereof. It can also be adapted to various uses such as for use, 120 hours, 240 hours, 360 hours, and 720 hours.
Furthermore, the shape of the molded body can also be arbitrarily designed. For example, if it is made into a frame shape, the outer diameter of the drug carrier gradually decreases as the end of use is approached, and thus the display function becomes clearer.

The chemical volatilization device of the present invention is simple and easy to operate, but of course, various functions may be added as long as it is allowed in terms of manufacturability and cost.
For example, the fan drive and pause cycles may be repeated to volatilize the drug intermittently, or a pilot lamp indicating switch-on may be separately loaded.

The chemical volatilization apparatus of the present invention thus obtained efficiently volatilizes and releases the drug from the drug carrier based on the wind power from the fan, and when an insecticidal component is used as the drug, Excellent insecticidal and insecticidal effects against various pests such as moths, flies and chironomids, and clothing pests such as moths and cutworms. And since the replacement | exchange time of a chemical | medical agent support body and the usage time of a motor can be easily recognized only by visually observing the disappearance state of a chemical | medical agent support body, it is very useful and practical.
Furthermore, since the medicine remaining amount display function is based on the medicine carrier itself, there is an advantage that the medicine carrier can be replaced and used independently regardless of the battery remaining amount of the dry battery.

Next, the chemical volatilization device of the present invention will be described in more detail based on specific examples and test examples.

FIG. 1 shows a sectional view of an example of the chemical volatilization apparatus of the present invention.
The drug volatilization apparatus 1 includes a cartridge 3 that contains a drug carrier 2, an axial fan 4 that is installed close to the cartridge 3, a motor 5 that drives the fan 4, and a dry battery 6 as a power source. ing. When the motor 5 is rotated, wind force is generated by the axial fan 4, and when the airflow passes through the cartridge 3, the drug is dissipated from the drug carrier 2 through the vent 7 into the air along the airflow.

In this example, for 120 hours, 15 mg of compound E [4-methyl-2,3,5,6-tetrafluorobenzyl-2,2-dimethyl-3- (1-propenyl) cyclopropanecarboxylate] Three drug carriers 2 having a thickness of 7 mm and supported on 1.2 g of a disk-shaped sunsably (colored blue) were used. That is, each of the three was stored in a 30 μm-thick polyester molded body (not shown) having a vent hole, and then installed in the cartridge 3 and attached to the drug volatilization apparatus 1. A motor 5 having a rotation speed of 1400 rpm was used, and the dry battery 6 was a single 1.5 V AAA battery.

After mounting the cartridge 3 on the drug volatilization apparatus 1, the switch was turned on, and it was lowered to the waist and engaged in garden work for 6 hours. During use, it was not bothered by mosquitoes and buoys, and a sufficient insect repellent effect was observed. In addition, the blue sunsabble gradually decreased with the course of use, and all disappeared after about 120 hours of use. The drug volatilization apparatus 1 is very practical because it is easy to operate and has a function of displaying a remaining amount of drug.

To 4.2 g of disc-shaped adamantane (colored green) having a thickness of 8 mm and an outer diameter of 2.8 cm, compound B [2,3,5,6-tetrafluorobenzyl-2,2-dimethyl-3- (1- Propenyl) cyclopropanecarboxylate] The drug carrier 2 carrying 40 mg and 5 mg of fragrance is wrapped in a flexible bag made of a breathable nonwoven fabric (material: rayon / polypropylene = 9/1, basis weight: 40 g / m ² ). It is. The periphery of the flexible bag is sandwiched between cartridges 3 (upper and lower frame plates having an outer diameter of 3.5 cm), and the specifications of the motor 5 and the dry battery 6 are the same as those in Example 1 for 100 hours. Was made.

When the chemical volatilization apparatus 1 was used at the entrance, it was effective for repelling mosquitoes and various pests for about 100 hours. After about 100 hours of use, the green sunsap disappeared, and the replacement time of the drug carrier 2 could be clearly recognized.

The lid of a rectangular hollow molded body (outer diameter 3.4 cm, inner diameter 2.0 cm, height 0.8 cm) having a breathable nonwoven fabric stretched on the side peripheral surface was removed, and compound M [4-methoxymethyl-2 , 3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate] 80 mg. A gelling agent A (0.4 g) and a blue pigment were added to dimethyl phthalate (3 g), dissolved by heating, and then poured into the molded product and allowed to cool. The lid is closed, and the resulting drug carrier 2 is housed in a slightly larger basket-like cartridge 3, and the specifications of the motor 5 and the dry battery 6 are the same as those in Example 1 for 200 hours. Was made.

When this chemical volatilization apparatus 1 was used in a pet shed, the dog was not bothered by mosquitoes and various pests for about 200 hours. After about 200 hours of use, the blue gel formed body almost disappeared, and the indication of the cartridge replacement time was clear.

According to Example 1, various drug volatilization apparatuses for 240 hours equipped with a cartridge for containing a drug carrier and a motor for driving a fan with a dry battery were produced, and a performance test was performed. In addition, the insecticidal efficacy is the initial overturning effect when the mosquito-repellent mat containing dl, d-cis / trans-allesrin (pinamin forte) is evaporated under the condition of a heating element heat sink temperature of 160 ° C. As a relative effective ratio.

The chemical volatilization apparatus of the present invention retains excellent insecticidal efficacy for a long period of 240 hours, can easily recognize the end point of the use period by the disappearance of the sublimable substance or gel former, It was also excellent.
On the other hand, as shown in Comparative Example 1, the one provided with the liquid crystal display by the electric control mechanism was accurate in displaying the end point, but the apparatus was complicated and the cost was inevitable. On the other hand, as in Comparative Example 2, the type that uses a dye linked to the remaining amount of the drug in the drug carrier and uses the color change for the end point display has a range of color tone after 240 hours and is unclear. Met.
Therefore, the usefulness of the present invention was confirmed.

Sectional drawing of an example of the chemical volatilization apparatus of this invention is shown.

Explanation of symbols

1: Drug volatilization device 2: Drug carrier 3: Cartridge 4: Axial fan 5: Motor 6: Dry cell 7: Vent

Claims (6)

In a drug volatilization apparatus that volatilizes the drug from the drug carrier based on wind power generated by a fan, the carrier is a sublimable substance or a gel-former, and the use process A drug volatilization apparatus characterized in that the end point of volatilization of the drug can be recognized by visually observing the disappearance state of the drug carrier. 2. The chemical volatilization device according to claim 1, wherein the sublimable substance is 2,4,6-triisopropyl-1,3,5-trioxane or adamantane. The drug volatilization apparatus according to claim 1, wherein the gel former contains an N-acylamino acid derivative-based gelling agent. The drug carrier is housed in a flexible bag formed of breathable paper or non-woven fabric. Even if the drug carrier shrinks with the progress of use, at least a part of the drug carrier is not contained in the flexible bag. The chemical volatilization device according to any one of claims 1 to 3, wherein the chemical volatilization device is in contact with the inner surface of paper or nonwoven fabric. The drug volatilization apparatus according to any one of claims 1 to 3, wherein the drug carrier is housed in a plastic molded body having a vent hole. The drug is represented by the general formula (I)

(Wherein X represents a hydrogen atom or a methyl group. When X is a hydrogen atom, Y represents a vinyl group, 1-propenyl group, 2-methyl-1-propenyl group, 2,2-dichlorovinyl group, 2, Represents a 2-difluorovinyl group or 2-chloro-2-trifluoromethylvinyl group, and when X is a methyl group, Y represents a methyl group, and Z represents a hydrogen atom, a fluorine atom, a methyl group, or a methoxymethyl group. Or a propargyl group), which is one or two selected from fluorine-substituted benzyl alcohol ester compounds.

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