JP2006131543A - Skin care preparation for external use containing oceanic skin benefit material - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a means for inhibiting a skin care preparation for external use containing an oceanic material from undergoing time-lapse changes, such as precipitations of starch, during storage, which results from the environmental difference of the material between dissolution in seawater and dissolution in the skin care preparation for external use. <P>SOLUTION: The skin care preparation for external use contains (1) the oceanic material selected from among sea mud, an oceanic algae extract, and oceanic collagen and (2) a polyethylene glycol having an average molecular weight of 100,000 to 5,000,000. It is preferable that the oceanic material contains fucoidan. It is preferable that the content of fucoidan is 0.01 to 1 mass%, in total, based on the total weight of the skin care preparation for external use. It is further preferable that it contains xanthan gum. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin which contains a marine raw material and is suitable for a skin lotion that does not easily cause starch or the like during storage.

  Marine raw materials such as sea mud, seaweed extract, and marine collagen contain minerals that rarely exist on land, or have physiological activities different from collagen derived from land animals. It is known to be useful as an additive component for external preparations for skin, such as having a skin moisturizing action and a hair care action. (For example, see Patent Literature 1, Patent Literature 2, Patent Literature 3, Patent Literature 4, Patent Literature 5, Patent Literature 6, Patent Literature 7, Patent Literature 8, Patent Literature 9, Patent Literature 10, and Patent Literature 11). Since marine raw materials are present in the ocean where salt is present, they often have an affinity for salt. For example, this is blended with a system in which an aqueous carrier such as lotion is present. By changing the environment in which it exists, it is not uncommon for changes in its dissolution state, and as a result, starch and the like may be produced during long-term storage. Although it does not exist, there is a possibility that it may be a loss in appearance. Therefore, it has been desired to develop a means for suppressing such a change in solution state.

  On the other hand, polyethylene glycol having a high degree of polymerization is known to have an effect of improving film properties in mascara and the like (see, for example, Patent Document 12 and Patent Document 13). In skin external preparations such as cosmetics, it has not been known at all that it has an inhibitory action on the precipitation of starch under storage conditions caused by the marine raw materials. 1) Sea mud, seaweed extract No skin external preparation containing a marine raw material such as marine collagen and 2) polyethylene glycol having an average molecular weight of 100,000 to 5,000,000 has not been known.

JP 2004-155684 A JP 2003-012448 A Japanese Patent Laid-Open No. 2002-338452 JP 2001-233722 A JP 2001-106622 A JP 2001-039855 A JP 2001-340751 A JP 2001-288045 A JP 2001-131031 A JP 2003-192701 A Japanese National Patent Publication No. 09-506098 Japanese Patent Application Laid-Open No. 11-079941 Japanese Patent Application Laid-Open No. 11-079940

  The present invention has been made under such circumstances, and in a skin external preparation containing a marine raw material, the marine raw material is contained in the skin external preparation, and occurs when the environment of the dissolution state is changed. It is an object of the present invention to provide a means for suppressing changes with time such as starch during storage.

In view of such a situation, the inventors of the present invention have a skin external preparation containing a marine raw material, the marine raw material is contained in the skin external preparation, and the environment of the dissolution state is changed. As a result of intensive research efforts to find a means to suppress the time-dependent change of starch, etc., it was found that such a suppression is possible by coexisting polyethylene glycol having an average molecular weight of 100,000 to 5,000,000, The invention has been completed. That is, the present invention is as follows.
(1) An external skin preparation containing 1) the following marine raw materials and 2) polyethylene glycol having an average molecular weight of 100,000 to 5,000,000.
(Marine raw material) Sea mud, seaweed extract, marine collagen (2) The skin external preparation according to (1), wherein the marine raw material contains fucoidan.
(3) The content of fucoidan in the external preparation for skin is 0.01 to 1% by mass in total with respect to the total amount of external preparation for skin, described in (1) or (2) Topical skin preparation.
(4) The external preparation for skin according to any one of (1) to (3), further comprising xanthan gum.
(5) The external preparation for skin according to any one of (1) to (4), wherein the pH is 7 or less.
(6) The external preparation for skin according to any one of (1) to (5), which is a lotion.

  According to the present invention, in a skin external preparation containing a marine raw material, the marine raw material is contained in the skin external preparation, and changes over time such as starch during storage that occur when the environment of the dissolution state is changed are suppressed. Means can be provided.

(1) Marine raw material which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing a marine raw material as an essential component. The marine raw material referred to in the present invention has a probability that the source is the marine animal or plant or a modified product thereof, and the animal or plant or modified product is in contact with seawater as an aqueous salt solution for a long time. The general name of the raw material of the external preparation for skin. Specific examples of such marine raw materials include sea mud, seaweed extract, marine collagen and the like. As the sea mud, vegetable corrosive mud containing sulfur-containing aluminum silicate as a main component and containing various minerals can be preferably exemplified, and these can be mined from the seabed. The mined sea mud can be used after drying, pulverization, etc., if necessary, and it is preferable to perform such treatment. Such sea mud already has commercially available products, and examples of such commercially available products include mironekton and mironekton R (Dainippon Kasei Co., Ltd.). Such sea mud contains sulfur-containing aluminum silicate as Merckmar, and is contained so that the amount of the sulfur-containing aluminum silicate is 0.001 to 0.1% by mass, more preferably 0.005 to 0.05% by mass. It is preferable. This is because if the amount of the sulfur-containing aluminum silicate is too small, the effectiveness of the sea mud may not be expressed, and if it is too large, the starch inhibitory effect of the present invention may not be sufficiently exhibited.

  The seaweed extract is not particularly limited, but usually a seaweed extract extracted from seaweeds belonging to green algae, red algae and / or brown algae is used. Examples of seaweeds belonging to green algae belong to, for example, squirrel spiders, hosimidro, mills, mosquitoes, scorpions, green squirrels, cicadas, blue grasses, hibiscus, crocodiles, chlorellas, scallops, volvox, etc. Examples of seaweeds belonging to red algae include, for example, echids, scorpions, cedars, kakrites, dals, proboscis, scallops, sea urchins, euphorbiaceae, oxenoris, chinolimo, etc. Examples of seaweeds that belong to brown algae include seaweeds that belong to Okinawa mozuku (Cladosiphon), Honda walla, kombu and the like. Particularly preferred are brown algae, especially Okinawa mozuku. Okinawa mozuku is a seaweed of the brown alga Nagamatsumo, generally called mozuku, is a filamentous, thin, branchy brown algae, characterized by having a lot of sticky matter on the surface of the frond. Preferable examples of the mozuku used in the present invention include ftmozuku (Tinocladia crassa), kuromo (Papenfussiella kuromo), Okinawa mozuku (Cladosiphon okamuranus), matsumo (Analipus japonicus), mozuku (Nemacystus decipiens) and the like. As the seaweed extract, an extract using an aqueous carrier is particularly preferable. In particular, an extract from hot water or an extract obtained by homogenizing with water and removing water-insoluble components by an operation such as centrifugation is preferable. In such an extract, fucoidan, which is a polysaccharide, is the effective mark of the extract. When the seaweed extract is contained in the external preparation for skin of the present invention, the extract is such that the content of fucoidan is 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass. It is preferable to adjust and contain the total amount. This is because if the amount of fucoidan is too small, the effectiveness of the seaweed extract may not be expressed, and if it is too large, the starch inhibitory effect of the present invention may not be sufficiently exhibited.

  As marine collagen, fish is used as a base animal, for example, after pulverizing tissues containing collagen such as bones, skin, tendons, and sea urchins, washing with water, extraction with a dilute salt solution, extraction with an acid or alkali solution, Extraction with an enzyme such as pepsin, trypsin or hyaluronidase can be performed by performing known purification means such as salting out or dialysis to purify the collagen. It can also be obtained as “regenerated collagen” by a generally known method. In the skin external preparation of the present invention, the marine collagen is preferably contained in an amount of 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass. This is because if the amount of the marine collagen is too small, the effect of the marine collagen may not be exhibited, and if it is too large, the effect of inhibiting the starch of the present invention may not be sufficiently exhibited.

  In the skin external preparation of the present invention, such marine raw materials can be contained alone or in combination of two or more. A particularly preferred form is a form containing at least one of each of the three classifications of sea mud, seaweed extract, and marine collagen in the above amount range. This is because the effect of inhibiting the formation of starch by polyethylene glycol having a high polymerization degree, which is an essential component described later, acts independently for each class.

(2) Polyethylene glycol having an average molecular weight of 100,000 to 5,000,000, which is an essential component of the external preparation for skin of the present invention, the external preparation for skin of the present invention contains polyethylene glycol having an average molecular weight of 100,000 to 5,000,000 as an essential component. Features. Such a polyethylene glycol already has a commercial product, and such a commercial product can be purchased and used. Preferred examples of such commercially available products include Polyox WSR N-10 and N-30 manufactured by Union Carbide. These polyethylene glycols have an average molecular weight of 100,000 to 500,000. In the external preparation for skin of the present invention, such a polyethylene glycol is used when the marine raw material having an affinity for salt is contained in the external preparation for skin and the dissolved state is significantly different. Affinity changes, and has the effect of preventing the formation of starch after prolonged storage. In order to exert such an effect, one or more selected from polyethylene glycol having an average molecular weight of 100,000 to 5,000,000 is 0.001 to 0.01% by mass, more preferably 0.002%. It is preferable to contain -0.005 mass%. This is because if the amount is too small, the above-mentioned effect may not be achieved, and if the amount is too large, the viscosity may be too high or stickiness may be impaired.

(3) Skin external preparation of the present invention The skin external preparation of the present invention includes 1) marine raw materials such as sea mud, seaweed extract, marine collagen, and 2) polyethylene glycol having an average molecular weight of 100,000 to 5,000,000. It is characterized by containing. In the external preparation for skin of the present invention, in addition to such essential components, optional components usually used in external preparations for skin can be contained. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oils such as hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, Polyhydric alcohols such as tititol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, Moisturizing ingredients such as sodium pyrrolidone carboxylate, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose , Chondroitin sulfate, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroit , Mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfate, locust bean gum, succinoglucan, carolinic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, poly Thickeners such as sodium acrylate and bentonite, surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc. Body, surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, mica titanium , Fish phosphorus foil, bismuth oxychloride, etc. Pearls, which may be raked Red 202, Red 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201 Organic dyes such as red 213, yellow 204, yellow 203, blue 1, green 201, purple 201, red 204, polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, etc. Organic powders, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2 UV light such as'-hydroxy-5'-t-octylphenyl) benzotriazole, 4-methoxy-4'-t-butyldibenzoylmethane Collectors, lower alcohols such as ethanol and isopropanol, vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B12, vitamin B15 or derivatives thereof, etc. Vitamin E such as vitamin B, α-tocopherol, β-tocopherol, γ-tocopherol and vitamin E acetate, vitamin D such as vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like can be preferably exemplified. Particularly preferred is xanthan gum having a starch formation inhibitory action together with the polyethylene glycol having an average molecular weight of 100000 to 5000000. The xanthan gum is preferably contained in an amount of 0.01 to 0.5% by mass, more preferably 0.05. It is -0.3 mass%. The skin external preparation of this invention can be manufactured by processing these essential components and arbitrary components according to a conventional method.

  In addition, the external preparation for skin of the present invention can be applied without particular limitation as long as it is applied externally to the skin. For example, it can be preferably used as a skin external medicine, cosmetics, skin external goods, etc. It is particularly preferable to apply to a lotion. This is because transparency concerns important quality.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  A skin lotion that is an external preparation for skin according to the present invention was prepared according to the formulation shown below. That is, after the ingredients (a) and (b) were heated at 80 ° C. and mixed well, the ingredients (a) were gradually added to the mixture under stirring, followed by cooling with stirring to obtain the skin lotion 1 as an external preparation for skin of the present invention. . The pH of this product was 6.5.

<Test Example 1>
Using lotion 1 and comparative example 1 in which polyethylene glycol 400000 in lotion 1 was replaced with polyethylene glycol 20000, the formation of starch by long-term storage was examined. The storage condition was 3 months at 5 ° C. The degree of starch formation was evaluated based on a color difference with respect to distilled water (ΔE) and a four-step evaluation by visual observation (score 1: no starch, score 2: very slightly starch, score 3: slightly starch, score 4 : Clearly recognized starch). Lotion 1 was 0.11, while Comparative Example 1 was 0.34. The starch score was 1 for skin lotion 1 and 2 for comparative example 1.

  In the same manner as in Example 1, a lotion 2 that is a cosmetic of the present invention was prepared according to the following formulation. When this product was evaluated in the same manner as in Test Example 1, the color difference was 0.19, and the starch score was 1. The pH was 6.52.

  In the same manner as in Example 1, a lotion 3 that is a cosmetic of the present invention was prepared according to the following formulation. When this product was evaluated in the same manner as in Test Example 1, the color difference was 0.13, and the starch score was 1. The pH was 6.57.

  In the same manner as in Example 1, a lotion 3 that is a cosmetic of the present invention was prepared according to the following formulation. When this product was evaluated in the same manner as in Test Example 1, the color difference was 0.16, and the starch score was score 1. The pH was 6.57. This shows that it is preferable to contain xanthan gum.

  The present invention can be applied to cosmetics such as lotions.

Claims (6)

1) A skin external preparation containing the following marine raw materials and 2) polyethylene glycol having an average molecular weight of 100,000 to 5,000,000.
(Marine raw materials) Sea mud, seaweed extract, marine collagen The skin external preparation according to claim 1, wherein the marine raw material contains fucoidan. The skin external preparation according to claim 1 or 2, wherein the content of fucoidan in the external preparation for skin is 0.01 to 1% by mass in total with respect to the total amount of external preparation for skin. Furthermore, xanthan gum is contained, The skin external preparation in any one of Claims 1-3 characterized by the above-mentioned. The skin external preparation according to any one of claims 1 to 4, wherein the pH is 7 or less. It is a skin lotion, The skin external preparation in any one of Claims 1-5 characterized by the above-mentioned.