JP2006126187A - 反共振導波路センサを用いた試料の分析 - Google Patents
反共振導波路センサを用いた試料の分析 Download PDFInfo
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Abstract
【解決手段】試料を分析するためのシステム100は、ターゲット検体を含む、第1屈折率を有する試料116と、第2屈折率を有する上部層136及び第3屈折率を有する基板116とを備え、第2屈折率及び第3屈折率は前記第1屈折率より大きくされ、更に、光を試料内に指向させて試料内に反共振誘導光学モードを生成するための光源104と、試料内に伝搬する光とターゲット検体との相互作用(干渉)を検出するための分析システム140、144と、を備えている。
【選択図】図1
Description
によって与えられる。
がもたらされる。
ここでEは電界を示し、
はそのZ依存性を示し、kxは波ベクトルのx成分を示し、
は光真空波ベクトルであり、nは材料の屈折率である。
をもたらすことができる。これらの固有解は、光学モードと呼ばれる。方程式3及び方程式4もまた、それぞれの屈折率のNeff及びこれらのモードのモード閉じ込め係数Γの計算を可能にする。
すなわち、
である。
のように導くことができる。
)が、入射光の波長(λ=0.3μ・・・2μm)と比べて大きいとき、(数式5)の近似値が許容可能である。方程式4の近似値を使用することにより、有効屈折率neffに検体の屈折率nを代入することが可能になる。代入は、検体、コア層、及び外部の屈折率にのみ依存する入射角をもたらす。
104 光源
108 レンズ・システム
112 光ビーム
116 試料
120 入射角
128 表面
132 基板
136 被覆層
140、144 検出器
Claims (3)
- ターゲット検体を含有する試料の分析方法であって、
第1媒体の屈折率より小さく、第2媒体の屈折率よりも小さい屈折率を有する試料を、前記第1媒体と前記第2媒体の間に配置し、
光ビームを、反共振誘導光波(ARGOW)が前記試料を通って伝搬する角度で、該試料内に指向させ、
前記反共振誘導光波内の光と前記試料内の前記ターゲット検体との相互作用(干渉)を検出する、
ことを特徴とする方法。 - 請求項1に記載の方法において、前記第1媒体が前記試料にすぐ隣接する第1クラッド領域を含み、前記第2媒体が前記試料にすぐ隣接する第2クラッド領域を含み、前記第1クラッド領域は変動する屈折率を有し、前記第1クラッド領域は、前記試料と前記第1媒体の界面からの2つの波長の距離に対して、その距離と共に単調に増加する屈折率を有する、ことを特徴とする方法。
- 試料を分析するためのシステムであって、
ターゲット検体を含む、第1屈折率を有する試料と、
第2屈折率を有する上部層及び第3屈折率を有する前記試料を囲む基板とを備え、前記第2屈折率及び前記第3屈折率は前記第1屈折率より大きくされており、
更に、光を前記試料内に指向させて該試料内に反共振誘導光学モードを生成するための光源と、
前記試料内に伝搬する光と前記ターゲット検体との相互作用(干渉)を検出するための分析システムと、を備えている
ことを特徴とするシステム。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/976,434 US7268868B2 (en) | 2004-10-29 | 2004-10-29 | Anti-resonant waveguide sensors |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006126187A true JP2006126187A (ja) | 2006-05-18 |
JP4414953B2 JP4414953B2 (ja) | 2010-02-17 |
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Application Number | Title | Priority Date | Filing Date |
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JP2005306837A Expired - Fee Related JP4414953B2 (ja) | 2004-10-29 | 2005-10-21 | 反共振導波路センサを用いた試料の分析 |
Country Status (4)
Country | Link |
---|---|
US (2) | US7268868B2 (ja) |
EP (1) | EP1653217B1 (ja) |
JP (1) | JP4414953B2 (ja) |
DE (1) | DE602005007305D1 (ja) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1728065A1 (en) * | 2003-11-28 | 2006-12-06 | Lumiscence A/S | An examination system for examination of a specimen; sub-units and units therefore, a sensor and a microscope |
US7291824B2 (en) * | 2005-12-22 | 2007-11-06 | Palo Alto Research Center Incorporated | Photosensing throughout energy range and in subranges |
US7522786B2 (en) * | 2005-12-22 | 2009-04-21 | Palo Alto Research Center Incorporated | Transmitting light with photon energy information |
US7310153B2 (en) * | 2004-08-23 | 2007-12-18 | Palo Alto Research Center, Incorporated | Using position-sensitive detectors for wavelength determination |
US7268868B2 (en) | 2004-10-29 | 2007-09-11 | Palo Alto Research Center Incorporated | Anti-resonant waveguide sensors |
US7561264B2 (en) * | 2005-02-09 | 2009-07-14 | Chemimage Corporation | System and method for the coincident deposition, detection and identification of threat agents |
US7547904B2 (en) * | 2005-12-22 | 2009-06-16 | Palo Alto Research Center Incorporated | Sensing photon energies emanating from channels or moving objects |
US7386199B2 (en) * | 2005-12-22 | 2008-06-10 | Palo Alto Research Center Incorporated | Providing light to channels or portions |
US7358476B2 (en) * | 2005-12-22 | 2008-04-15 | Palo Alto Research Center Incorporated | Sensing photons from objects in channels |
US7433552B2 (en) * | 2005-12-22 | 2008-10-07 | Palo Alto Research Center Incorporated | Obtaining analyte information |
US7420677B2 (en) * | 2005-12-22 | 2008-09-02 | Palo Alto Research Center Incorporated | Sensing photon energies of optical signals |
US7248361B2 (en) * | 2005-12-22 | 2007-07-24 | Palo Alto Research Center Incorporated | Fluorescence reader based on anti-resonant waveguide excitation |
US8437582B2 (en) | 2005-12-22 | 2013-05-07 | Palo Alto Research Center Incorporated | Transmitting light with lateral variation |
US7315667B2 (en) * | 2005-12-22 | 2008-01-01 | Palo Alto Research Center Incorporated | Propagating light to be sensed |
US7718948B2 (en) * | 2006-12-04 | 2010-05-18 | Palo Alto Research Center Incorporated | Monitoring light pulses |
JP2010513910A (ja) * | 2006-12-21 | 2010-04-30 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | ワイヤグリッドウェーブガイド及び方法 |
US9164037B2 (en) | 2007-01-26 | 2015-10-20 | Palo Alto Research Center Incorporated | Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances |
US8821799B2 (en) | 2007-01-26 | 2014-09-02 | Palo Alto Research Center Incorporated | Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity |
US7817276B2 (en) | 2007-02-05 | 2010-10-19 | Palo Alto Research Center Incorporated | Distinguishing objects |
US7502123B2 (en) * | 2007-02-05 | 2009-03-10 | Palo Alto Research Center Incorporated | Obtaining information from optical cavity output light |
US7936463B2 (en) * | 2007-02-05 | 2011-05-03 | Palo Alto Research Center Incorporated | Containing analyte in optical cavity structures |
US7633629B2 (en) | 2007-02-05 | 2009-12-15 | Palo Alto Research Center Incorporated | Tuning optical cavities |
US7545513B2 (en) * | 2007-02-05 | 2009-06-09 | Palo Alto Research Center Incorporated | Encoding optical cavity output light |
US7554673B2 (en) * | 2007-02-05 | 2009-06-30 | Palo Alto Research Center Incorporated | Obtaining information about analytes using optical cavity output light |
US7529438B2 (en) * | 2007-07-13 | 2009-05-05 | Palo Alto Research Center Incorporated | Producing fluidic waveguides |
US7522811B2 (en) * | 2007-07-13 | 2009-04-21 | Palo Alto Research Center Incorporated | Producing sandwich waveguides |
US8320983B2 (en) | 2007-12-17 | 2012-11-27 | Palo Alto Research Center Incorporated | Controlling transfer of objects affecting optical characteristics |
US7817254B2 (en) * | 2008-01-30 | 2010-10-19 | Palo Alto Research Center Incorporated | Obtaining information from time variation of sensing results |
US8153949B2 (en) * | 2008-12-18 | 2012-04-10 | Palo Alto Research Center Incorporated | Obtaining sensing results indicating time variation |
US7763856B2 (en) * | 2008-01-31 | 2010-07-27 | Palo Alto Research Center Incorporated | Producing time variation in emanating light |
JP5541764B2 (ja) * | 2008-01-30 | 2014-07-09 | パロ・アルト・リサーチ・センター・インコーポレーテッド | 物体検出に応答して情報を取得する装置及び方法 |
EP2085797B1 (en) * | 2008-01-30 | 2016-06-01 | Palo Alto Research Center Incorporated | Producing Filters with Combined Transmission and/or Reflection Functions |
US7894068B2 (en) * | 2008-02-04 | 2011-02-22 | Palo Alto Research Center Incorporated | Producing filters with combined transmission and/or reflection functions |
JP5620642B2 (ja) * | 2008-01-30 | 2014-11-05 | パロ・アルト・リサーチ・センター・インコーポレーテッドPaloAlto ResearchCenterIncorporated | 符号器付センサを用いる方法、符号器付センサ及びシステム |
US7701580B2 (en) * | 2008-02-01 | 2010-04-20 | Palo Alto Research Center Incorporated | Transmitting/reflecting emanating light with time variation |
JP5503154B2 (ja) * | 2008-01-30 | 2014-05-28 | パロ・アルト・リサーチ・センター・インコーポレーテッド | 変換領域内の物体の不均一な相対運動を生起するシステム及び方法 |
EP2085762B1 (en) * | 2008-01-30 | 2018-07-04 | Palo Alto Research Center Incorporated | Transmitting/reflecting emanating light with time variation |
EP2085760B1 (en) * | 2008-01-30 | 2018-07-04 | Palo Alto Research Center Incorporated | Producing time variation in emanating light |
US8629981B2 (en) | 2008-02-01 | 2014-01-14 | Palo Alto Research Center Incorporated | Analyzers with time variation based on color-coded spatial modulation |
US8373860B2 (en) | 2008-02-01 | 2013-02-12 | Palo Alto Research Center Incorporated | Transmitting/reflecting emanating light with time variation |
US7805028B2 (en) * | 2008-03-25 | 2010-09-28 | Hewlett-Packard Development Company, L.P. | Optical sensor and method employing half-core hollow optical waveguide |
US7903913B2 (en) * | 2008-08-01 | 2011-03-08 | Alcatel-Lucent Usa Inc. | Optical apparatus |
US7830517B2 (en) * | 2008-09-05 | 2010-11-09 | Palo Alto Research Center Incorporated | Flow schemes for enhanced light-target interaction in fluidic channels |
EP3370060B1 (en) * | 2008-10-21 | 2023-06-07 | ChemoMetec A/S | Apparatus and method for illuminating a sample |
US8331751B2 (en) * | 2009-03-02 | 2012-12-11 | mBio Diagnositcs, Inc. | Planar optical waveguide with core of low-index-of-refraction interrogation medium |
US9658222B2 (en) | 2009-03-02 | 2017-05-23 | Mbio Diagnostics, Inc. | Planar waveguide based cartridges and associated methods for detecting target analyte |
US9212995B2 (en) | 2009-03-02 | 2015-12-15 | Mbio Diagnostics, Inc. | System and method for detecting multiple molecules in one assay |
US8300993B2 (en) * | 2009-03-02 | 2012-10-30 | Mbio Diagnostics, Inc. | Waveguide with integrated lens |
US8994946B2 (en) | 2010-02-19 | 2015-03-31 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
AU2011217862B9 (en) | 2010-02-19 | 2014-07-10 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
EP2616797B1 (en) | 2010-09-15 | 2017-01-11 | MBIO Diagnostics Inc. | System and method for detecting multiple molecules in one assay |
US10114020B2 (en) | 2010-10-11 | 2018-10-30 | Mbio Diagnostics, Inc. | System and device for analyzing a fluidic sample |
US8723140B2 (en) | 2011-08-09 | 2014-05-13 | Palo Alto Research Center Incorporated | Particle analyzer with spatial modulation and long lifetime bioprobes |
US9029800B2 (en) | 2011-08-09 | 2015-05-12 | Palo Alto Research Center Incorporated | Compact analyzer with spatial modulation and multiple intensity modulated excitation sources |
CN102621118B (zh) * | 2012-03-18 | 2013-11-06 | 吉林大学 | 温室蔬菜病虫害的预警方法 |
EP2911791A4 (en) | 2012-10-29 | 2016-11-02 | Mbio Diagnostics Inc | SYSTEM FOR IDENTIFYING BIOLOGICAL PARTICLES, CARTRIDGE AND ASSOCIATED METHODS |
CN103822911A (zh) * | 2013-12-11 | 2014-05-28 | 华东交通大学 | 基于光波导振荡场传感器的拉曼光谱增强装置 |
DE102014104595A1 (de) * | 2014-04-01 | 2015-10-01 | Michael Himmelhaus | Verfahren und Vorrichtung zur labelfreien Detektion eines Analyten |
CN104483270B (zh) * | 2014-12-19 | 2017-07-11 | 重庆川仪自动化股份有限公司 | 一种紫外差分分析仪的气体池 |
CN104833747B (zh) * | 2015-05-06 | 2016-08-24 | 华东理工大学 | 一种采用深紫外led光源的制备色谱用紫外检测器 |
EP3292220B1 (en) | 2015-05-07 | 2022-07-13 | Pacific Biosciences of California, Inc. | Multiprocessor pipeline architecture |
DE102015217425A1 (de) * | 2015-09-11 | 2017-03-16 | Robert Bosch Gmbh | Lichtleitvorrichtung, Messsystem und Verfahren zum Herstellen einer Lichtleitvorrichtung |
CN109154554A (zh) * | 2016-05-27 | 2019-01-04 | 卓金星 | 微生物检测系统 |
GB2580652A (en) * | 2019-01-21 | 2020-07-29 | Res & Innovation Uk | Infrared spectrometer |
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US6603548B2 (en) * | 1999-12-03 | 2003-08-05 | Sciperio, Inc. | Biosensor |
GB0023041D0 (en) * | 2000-09-20 | 2000-11-01 | Univ Manchester | Identification apparatus |
US6577780B2 (en) * | 2001-03-08 | 2003-06-10 | Veridian Systems | Cell designs for optical biosensors |
JP2005306837A (ja) | 2004-03-26 | 2005-11-04 | Tokuyama Corp | アダマンタノール類の製造方法 |
US7268868B2 (en) | 2004-10-29 | 2007-09-11 | Palo Alto Research Center Incorporated | Anti-resonant waveguide sensors |
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US20080013877A1 (en) | 2008-01-17 |
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