JP2006104108A - Gel-like composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a translucent to milky opaque or solid gel-like composition useful as a cosmetic, and the like, causing an excellent beautiful appearance without a sticky feeling or an occlusive feeling during use and assuming a creamy and smooth touch. <P>SOLUTION: This gel-like composition is characterized as comprising at least one kind of N-acylamino acid (A) represented by formula (1) (wherein, R<SB>1</SB>denotes a 1-25C straight-chain or branched chain saturated hydrocarbon group or an unsaturated hydrocarbon group which may contain an aromatic ring; and X denotes an aliphatic or an aromatic α-, β- or γ-amino acid), at least one kind of oily base (B) and at least one kind of higher fatty acid (C). <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a gel composition containing a specific N-acylamino acid, an oily base and a higher fatty acid, a production method, and a cosmetic product.

  Conventionally, as a gelling agent for an oil-based base that does not dissolve in water, generally, a condensation product of an aromatic aldehyde and a polyhydric alcohol typified by polyamide resin, 12-hydroxystearic acid and dibenzylidene-D-sorbitol Etc. are known. However, the gel composition for cosmetics using these gelling agents is in a poor dissolved state, the gel composition for cosmetics becomes non-uniform, and the gelled oily base is removed from the surface of the gel due to changes over time. There was a problem that a so-called “sweat phenomenon” that oozes out.

  Further, N-acyl-L-glutamic acid dibutylamide has been proposed as a gelling agent for other oily bases (see Patent Documents 1 and 2). This is known to gel various oily bases, but the resulting gelled oily base is a relatively hard gel, when used as a cosmetic to apply the gel composition to the skin, The dosage form is fragile, causing a problem in strength, and its usage is sometimes limited. Further, there is a problem that the solubility in a general oil base is low, and a relatively high temperature is required when dissolving the gelling agent.

  Furthermore, although an antiperspirant gel stick containing 12-hydroxystearic acid and N-lauroyl-L-glutamic acid dibutylamide has been proposed (see Patent Documents 3 and 4), the resulting gelled oil base is a comparative example. It is a hard gel, its dosage form is fragile, there is a problem in strength, and its use is sometimes limited.

  Moreover, although it has also been proposed to gelatinize an oily base using a fatty acid dextrin ester as a gelling agent (see Patent Document 5), the amount of gelling agent used is as high as 10 wt% or more in any prescription, In addition, since the gelling agent itself is a polymer compound having a relatively large molecular weight, it is not preferable because it has a strong film feeling when used on the skin and hair. In addition, the fatty acid dextrin ester has limited oily bases that can be gelled, for example, silicone oil cannot be gelled.

Japanese Patent Laid-Open No. 51-19139 JP 2002-316971 A US Pat. No. 5,591,424 Japanese National Patent Publication No. 7-506833 Japanese Patent Laid-Open No. 08-047635

  The object of the present invention is to solve the above-mentioned problems of the prior art, have a translucent to milky creamy or solid form and have an excellent aesthetic appearance, no stickiness or blockage when used, and excellent spreadability. The object is to provide a gel-like composition useful as a cosmetic or the like.

  As a result of intensive studies in view of the above problems, the present inventors contain at least one selected from a specific N-acylamino acid, at least one selected from an oily base, and at least one selected from higher fatty acids. It has been found that the gel-like composition is translucent to milky creamy or solid and excellent in aesthetics, and exhibits a creamy and smooth feel when used in cosmetics, etc., leading to the completion of the present invention. It was.

（式中、Ｒ_１は炭素原子数１〜２５の直鎖もしくは分岐鎖の飽和炭化水素基、または芳香環を含んでいても良い不飽和炭化水素基を表し、そしてXは脂肪族または芳香族のα−、β−またはγ−アミノ酸を表す。）
（２）該Ｎ−アシルアミノ酸（Ａ）がＮ−アシル中性アミノ酸であることを特徴とする上記（１）に記載のゲル状組成物。
（３）該Ｎ−アシルアミノ酸（Ａ）がＮ−アシル−Ｌ−アラニンであることを特徴とする上記（１）〜（２）のいずれかに記載のゲル状組成物。
（４）該Ｎ−アシルアミノ酸（Ａ）がＮ−２−エチルヘキサノイル−Ｌ−アラニン、Ｎ−カプリロイル−Ｌ−アラニン、Ｎ−カプロイル−Ｌ−アラニン、Ｎ−ラウロイル−Ｌ−アラニン、Ｎ−ミリストイル−Ｌ−アラニン、Ｎ−パルミトイル−Ｌ−アラニンから選ばれたＮ−アシル−Ｌ−アラニンであることを特徴とする上記（１）〜（３）のいずれかに記載のゲル状組成物。
（５）該Ｎ−アシルアミノ酸（Ａ）が、Ｎ−ラウロイル−Ｌ−アラニンであることを特徴とする上記（１）〜（４）のいずれかに記載のゲル状組成物。
（６）該油性基剤（Ｂ）が炭化水素油またはシリコーン油であることを特徴とする上記（１）〜（５）のいずれかに記載のゲル状組成物。
（７）以下の工程を含む、上記（１）〜（６）のいずれかに記載のゲル状組成物の製造方法。
１）ゲル化剤、油性基剤、その他添加剤を均一に加熱溶解する工程
２）攪拌冷却する工程
（８）上記（１）〜（６）のいずれかに記載のゲル状組成物を含有することを特徴とする香粧品。 That is, the present invention can be configured as follows.
(1) Contains at least one N-acylamino acid (A) represented by the following general formula (1), at least one oily base (B), and at least one higher fatty acid (C). A gel-like composition characterized by the above.

(Wherein R ₁ represents a linear or branched saturated hydrocarbon group having 1 to 25 carbon atoms, or an unsaturated hydrocarbon group which may contain an aromatic ring, and X is aliphatic or aromatic. Represents an α-, β-, or γ-amino acid.
(2) The gel composition as described in (1) above, wherein the N-acylamino acid (A) is an N-acyl neutral amino acid.
(3) The gel composition according to any one of (1) to (2) above, wherein the N-acylamino acid (A) is N-acyl-L-alanine.
(4) The N-acylamino acid (A) is N-2-ethylhexanoyl-L-alanine, N-capryloyl-L-alanine, N-caproyl-L-alanine, N-lauroyl-L-alanine, N- The gel composition according to any one of (1) to (3) above, which is N-acyl-L-alanine selected from myristoyl-L-alanine and N-palmitoyl-L-alanine.
(5) The gel composition according to any one of (1) to (4) above, wherein the N-acylamino acid (A) is N-lauroyl-L-alanine.
(6) The gel composition according to any one of (1) to (5) above, wherein the oily base (B) is a hydrocarbon oil or a silicone oil.
(7) The manufacturing method of the gel-like composition in any one of said (1)-(6) including the following processes.
1) Step of uniformly heating and dissolving gelling agent, oily base, and other additives 2) Step of stirring and cooling (8) Containing the gel composition according to any one of (1) to (6) above A cosmetic product characterized by that.

  According to the present invention, it is possible to obtain a translucent to milky cream-like or solid gel-like composition having excellent aesthetics, and this gel-like composition was used as a cosmetic composition such as a cosmetic. In some cases, the obtained cosmetic product does not have a sticky feeling or a clogging feeling and has excellent spreadability.

Hereinafter, embodiments of the present invention will be described in detail.
In the present invention, at least one N-acylamino acid (A) represented by the following general formula (1) is used as a gelling agent component constituting the gel composition.

(Wherein R ₁ represents a linear or branched saturated hydrocarbon group having 1 to 25 carbon atoms, or an unsaturated hydrocarbon group containing an aromatic ring, and X represents an aliphatic or aromatic α-, represents β- or γ-amino acid.)

  Examples of the amino acid part of the N-acylamino acid (A) (X in the general formula (1)) include acidic amino acids such as glutamic acid and aspartic acid; glycine, alanine, valine, leucine, isoleucine, serine, N such as threonine, cysteine, cystine, methionine, asparagine, glutamine, methylglycine, β-alanine, N-methyl-β-alanine, γ-aminobutyric acid, taurine, N-methyltaurine, phenylalanine, tyrosine, proline, tryptophan, etc. -Acyl neutral amino acids; basic amino acids such as lysine, arginine, ornithine and the like. Only one of these may be used, or two or more may be used in combination. Among these, acyl neutral amino acids are preferable, and alanine is more preferable. The optical activity of the amino acid to be used is not particularly limited, and any of racemic, L, and D forms may be used. From the viewpoint of obtaining a gel having high temperature stability, the optical activity (L form or Is preferably D-form).

An acyl group of N- acylamino acid, the general formula (1) R ₁ in a linear or branched chain saturated hydrocarbon group having 1 to 25 carbon atoms or which may unsaturated hydrocarbons include an aromatic ring, It is an acyl group which is a hydrogen group, and preferably has R ₁ having 5 to 21 carbon atoms, more preferably 7 to 17 carbon atoms. The unsaturated hydrocarbon group that may contain an aromatic ring means that part or all of the unsaturated bond may be derived from the aromatic ring. Preferred acyl groups include aliphatic acyl groups such as 2-ethylhexanoyl, octanoyl, decanoyl, lauroyl, myristoyl, palmitoyl, stearoyl groups, and among them, lauroyl group is particularly preferred.

  The N-acylamino acid (A) of the present invention can be produced by N-acylation of an amino acid by a conventional method. For example, a Schotten-reactant that reacts a fatty acid halide with an amino acid under a basic catalyst such as sodium hydroxide. It can be obtained by Baumann reaction.

  As the oily base (B) used in the gel composition of the present invention, any gel can be formed as long as the gelling agent is sufficiently dissolved or uniformly dispersed by heating and forms a gel when cooled to room temperature. Specific examples include, but are not limited to, methylpolysiloxane, highly polymerized methylpolysiloxane, polyoxyethylene / methylpolysiloxane copolymer, polyoxypropylene / methylpolysiloxane copolymer, and poly (oxyethylene, oxypropylene) -Ether-modified silicone such as methylpolysiloxane copolymer, stearoxymethylpolysiloxane, stearoxytrimethylsilane, methylhydrogenpolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, decamethylcyclopentasiloxane, octamethylcyclotetra Siloxane Cyclic silicones such as tetrahydrotetramethylcyclotetrasiloxane, methylcyclopolysiloxane, cyclopentasiloxane and dodecamethylcyclohexasiloxane, 1,1,5,5-tetraphenyltrisiloxane, methylphenylpolysiloxane, trimethylsiloxysilicate, amino Amino-modified silicone such as ethylaminopropylsiloxane / dimethylsiloxane copolymer, silanol-modified polysiloxane, alkoxy-modified polysiloxane, fatty acid-modified polysiloxane, fluorine-modified polysiloxane, epoxy-modified polysiloxane, alkoxy-modified polysiloxane perfluoropolyether, Silicone oil selected from the group consisting of polyvinyl acetate dimethylpolysiloxane and the like, and mixtures thereof; cetyl alcohol, isoste Higher alcohols such as ril alcohol, lauryl alcohol, hexadecyl alcohol, octyldodecanol; myristyl myristate, hexyl laurate, decyl oleate, isopropyl myristate, hexyl decyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, mono Esters such as ethylene glycol stearate and octyl oxystearate; hydrocarbons such as liquid paraffin, petrolatum and squalane; waxes such as lanolin, reduced lanolin and carnauba wax; mink oil, cacao oil, coconut oil, palm kernel oil, camellia oil And oils such as sesame oil, castor oil and olive oil; ethylene / α-olefin / co-oligomer and the like. Only one of these may be used, or two or more may be used in combination. Preferred oily bases include silicone oil, ester oil, hydrocarbon oil, oil and fat. More preferred are silicone oil and hydrocarbon oil, and particularly preferred is silicone oil.

  Although the compounding quantity of (A) component used by this invention is not specifically limited, Preferably it is 0.01-30 wt% with respect to the total amount of (A) component and (B) component, More preferably, it is 0.1 -20 wt%, particularly preferably 0.5-10 wt%. When the N-acylamino acid content is less than 0.01 wt%, sufficient gel strength cannot be obtained, and in some cases, the oily base may be partially separated. Moreover, when it exceeds 30 wt%, it will become difficult to melt | dissolve or disperse | distribute uniformly to an oil-based base, and it may precipitate as a solid substance in the gel-like composition obtained depending on the case.

  The total amount of the component (A) and the component (B) of the present invention is usually used at 1 to 99.99 wt% with respect to the total amount of the composition (the total amount of the component (A), the component (B) and other components). . When the blending amount of the oily base is less than 1 wt% or more than 99.99 wt%, sufficient gel strength cannot be obtained, or the N-acylamino acid cannot be completely dissolved, and the gel composition When used in cosmetics or the like, the touch tends to be greatly impaired.

  As a preferred embodiment of the present invention comprising two components, a gelling agent (A) and an oily base (B), the gelling agent (A) (that is, N-acylamino acid (A)) is N-acyl-L- Examples include alanine in which the oil base (B) is silicone oil or hydrocarbon oil. In the most preferred embodiment, the gelling agent (A) is N-acyl-L-alanine, and the oily base (B) is silicone oil, particularly methylpolysiloxane, highly polymerized methylpolysiloxane, octamethyltrisiloxane, A silicone oil selected from demethyltetrasiloxane, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, methylcyclopolysiloxane, dodecamethylcyclohexasiloxane, methylphenylpolysiloxane, and the like.

  The higher fatty acid (C) used in the gel composition of the present invention suppresses partial crystallization of the N-acylamino acid in the gel composition and is applied to the skin and hair. It is creamy and is used for the purpose of making the sensory surface excellent in smoothness, and there is no particular limitation as long as such an object can be achieved. Specific examples include 2-ethylhexanoic acid and caprylic acid. , Capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, coconut oil fatty acid, hardened beef tallow fatty acid, palm oil fatty acid, hardened palm oil fatty acid, safflower oil fatty acid, beef tallow fatty acid, behenic acid, oleic acid, isostearic acid, etc. Is mentioned. Only one of these may be used, or two or more may be used in combination. From the viewpoint of excellent feel such as spreadability, lauric acid, myristic acid, palmitic acid, stearic acid, coconut oil fatty acid, behenic acid, oleic acid, isostearic acid are preferred, lauric acid, myristic acid, palmitic acid, stearic acid, Isostearic acid is particularly preferred.

  The compounding quantity of (C) component of this invention is used at 0.01-30 wt% with respect to (A) component. When the amount is less than 0.01 wt%, the effect of preventing precipitation of N-acylamino acid (A) is insufficient, or a sufficient creamy and smooth feel cannot be obtained. It tends to be impossible to obtain gel strength. From the viewpoint of stably maintaining the creamy and smooth characteristics, it is preferably 0.1 to 20 wt%, more preferably 1 to 15 wt%, and particularly preferably 1 to 10 wt%.

  Although it does not specifically limit as a manufacturing method of the gel-like composition of this invention, For example, when manufacturing the gel-like composition which consists of a gelatinizer (A), an oil-based base (B), and a higher fatty acid (C). While stirring these three components until the gelling agent (A) is dissolved or melted, for example, the mixture is heated to about 50 ° C. or higher, and then stirred or allowed to cool to obtain the desired gel composition. Can do. At that time, a gelling composition (A) such as N-acyl-L-alanine, an oily base (B) and a higher fatty acid (C) are heated and melted, and then cooled with stirring to produce a gel composition. In this case, a partial crystal of the gelling agent (A) such as N-acyl-L-alanine is not formed, the extensibility of the gel-like composition is improved, and the appearance is also preferable.

  The gel composition of the present invention can be made into products of various cosmetics and fragrances as they are or by further blending various components used in cosmetics and fragrances. Therefore, the gel composition of the present invention containing the above-described three components is not limited to (A) component, (B) component and (C) component (narrow sense), but also in a narrow sense gel composition. To which various other components are added (in a broad sense).

  When the gel composition of the present invention is used as a cosmetic composition, various components to be blended include various chelating agents to suppress discoloration of the composition and generation of odor. The chelating agent is not particularly limited, but preferably triethylenetetramine, 1,1,1-trifluoro-3,2′-thenoylacetone, thioglycolic acid, tartaric acid, succinic acid, 8-quinolinol, pyridine- 2,6-dicarboxylic acid, pyridine, 1,10-tenanthroline, lactic acid, 8-hydroxyquinoline-5-sulfonic acid, glycine, 2,2′-pyridylethylenediamine, aurintricarboxylic acid, xylenol orange, 5-sulfosalicylic acid, Salicylic acid, pyrocatechol-3,5-disulfonate, 4,5-dihydroxybenzene-1,3-disulfonic acid, 1,2-diaminocyclohexane-N, N, N ′, N′-tetraacetic acid, citric acid, oxalate Nitrilotriacetic acid, ethylenediamine-N, N, N ′, N′-tetraacetic acid, acetyl Seton chelating agents and mixtures thereof is selected from the group consisting of salts and the like.

  Moreover, as still another blending component, a gelling agent of an oily base (B) other than the N-acylamino acid (A) can be used in combination. For example, N-acyl-L-glutamic acid dialkylamide, polyamide resin, 12-hydroxystearic acid, sodium stearate, dibenzylidene-D-sorbitol, fatty acid dextrin and the like.

  Moreover, water can be mix | blended as still another compounding component, and it can also be set as the cosmetic composition of W / O or O / W emulsion.

  In addition, in the cosmetic composition of the present invention, a surfactant, various additives, various powders, and the like can be appropriately blended as other blending components as long as the effects of the present invention are not impaired.

  Surfactants include N-long chain acyl acidic amino acid salts and N-long chain acyl neutral amino acid salts, such as N-long chain acyl amino acid salts, N-long chain fatty acid acyl-N-methyl taurine salts, alkyl sulfates, and the like. Anionic surfactant such as alkylene oxide adduct, fatty acid amide ether sulfate, metal salt and weak base salt of fatty acid, sulfosuccinic acid type surfactant, alkyl phosphate and its alkylene oxide adduct, alkyl ether carboxylic acid, etc .; Ether type surfactants such as ether and its alkylene oxide adduct, ester type surfactants such as glycerin ester and its alkylene oxide adduct, ether ester type surfactants such as sorbitan ester and its alkylene oxide adduct, Ester type surfactants such as salkylene fatty acid ester, glycerin ester, fatty acid polyglycerin ester, sorbitan ester, sucrose fatty acid ester, alkyl glucosides, hydrogenated castor oil pyroglutamic acid diester and its ethylene oxide adduct, and fatty acid alkanolamide Nonionic surfactants such as nitrogen-containing nonionic surfactants; aliphatic amine salts such as alkylammonium chloride and dialkylammonium chloride; aromatic 4 such as quaternary ammonium salts and benzalkonium salts thereof Cationic surfactants such as quaternary ammonium salts and fatty acid acyl arginine esters; and betaine type surfactants such as carboxybetaine, aminocarboxylic acid type surfactants, imidazoline type surfactants, It includes amphoteric surfactants of.

  Examples of various additives include amino acids such as glycine, L-alanine, DL-alanine, serine, threonine, arginine, glutamic acid, aspartic acid, leucine, and valine; glycerin, ethylene glycol, 1,3-butylene glycol, propylene Polyhydric alcohols such as glycol and isoprene glycol; polyamino acids including polyglutamic acid and polyaspartic acid and salts thereof, polyethylene glycol, gum arabic, alginate, xanthan gum, hyaluronic acid, hyaluronate, chitin, chitosan, water-soluble chitin , Carboxyvinyl polymer, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropyltrimethylammonium chloride, polydimethylmethylenepiperidinium chloride, polybiphenyl Water-soluble polymers such as rupyrrolidone derivative quaternary ammonium, cationized protein, collagen degradation product and derivatives thereof, acylated protein, polyglycerin, etc .; sugar alcohols such as mannitol and alkylene oxide adducts thereof; lower grades such as ethanol and propanol In addition to alcohol, etc., animal and plant extracts, nucleic acids, vitamins, enzymes, anti-inflammatory agents, bactericides, antiseptics, antioxidants, UV absorbers, chelating agents, antiperspirants, pigments, dyes, oxidation dyes, organic and inorganic Examples thereof include powders, pH adjusting agents, pearling agents, wetting agents and the like.

  Examples of various powders include resin powders such as nylon beads and silicone beads, nylon powder, metal fatty acid soap, yellow iron oxide, red iron oxide, black iron oxide, chromium oxide, cobalt oxide, carbon black, ultramarine, and bitumen , Zinc oxide, titanium oxide, zirconium oxide, silicon oxide, aluminum oxide, cerium oxide, titanium mica, boron nitride, barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, magnesium silicate, silicon carbide, dye, lake, sericite, Examples include mica, talc, kaolin, plate-like barium sulfate, butterfly-like barium sulfate, fine particle titanium oxide, fine particle zinc oxide, fine particle iron oxide, acyl lysine, acyl glutamic acid, acyl arginine, acyl glycine and other acyl amino acids, and further silicone treatment , Fluorinated compounds Treatment, silane coupling agent treatment, silane treatment organic titanate process, acylated lysine treatment, fatty acid treatment, metal soap treatment, oil treatment, may be each other by subjecting the surface treatment of the amino acid treatment or the like.

  There is no particular difficulty in producing a gel composition (in a broad sense) in which the above-mentioned various components are blended with a gel composition composed of the three components (A), (B) and (C). For example, all components can be combined and heated with stirring until the gelling agent (A) is dissolved or melted, and then stirring or standing cooling can be performed as described above. .

  The gel composition of the present invention can be used as a part of raw materials for cosmetics such as cosmetics and fragrances. The form of the cosmetic is not particularly limited. However, when it is used as a cosmetic, powder, cream, kneaded, and solid are preferable. Specifically, makeup makeup such as foundation, white powder, blusher, and eye shadow. Body cosmetics such as cosmetics, body powders, lotions, emulsions, beauty liquids, skin creams, suncare products, etc., cleansing agents such as makeup removers, facial cleansing foams, rinses, treatments, styling agents, antiperspirants, Examples thereof include hair cosmetics such as bath agents and hair dyes, and aromatic cosmetics such as solid, cream and liquid. When it is used as a fragrance, a cream form or a gel form is preferable, and specifically, a car fragrance, a household fragrance, or the like can be given.

  In addition, the gel composition of the present invention utilizes its good gelling properties to make stationery and paints such as paints, paints, solid paints, solid paints, oil-based inks; cairo, ice packs, paint cleaners, car cleaners Miscellaneous goods and toiletries such as waxes; Modifiers such as polyolefin resins; Pharmaceuticals and agricultural chemicals such as haps, gel pesticides and solid pesticides; Machine oils such as rust preventive oils, greases, lubricating oils and cutting oils; It can also be used as an asphalt modifier, a photographic emulsion, and the like.

  EXAMPLES Next, although an Example demonstrates this invention still in detail, this invention is not limited to a following example.

<Production Example 1; Production of N-lauroyl-L-alanine>
To 110 g of L-alanine, 290 g of water, 230 g of t-BuOH, and 27% aqueous sodium hydroxide solution are added and dissolved to adjust the pH to 11. It was cooled to 10 ° C., and 269 g of lauroyl chloride and a 27% aqueous sodium hydroxide solution were added dropwise while maintaining the pH at 11. After completion of the reaction, the acylation reaction solution was neutralized with 75% sulfuric acid, the pH was adjusted to 2, and the aqueous layer was removed by oil separation at 60 ° C. 757 g of water was poured into the obtained oil layer, and after stirring, oily separation was performed. An appropriate amount of IPA (isopropyl alcohol) was added to the oil layer and cooled to obtain 320 g of a white crystalline substance. Furthermore, after recrystallizing it with an IPA solvent, the obtained white crystalline substance was dried at 50 ° C. under reduced pressure to obtain N-lauroyl-L-alanine.

<Production Example 2>
The pH is adjusted to 11 by adding 188.55 g of water and 54.1 g of a 27% aqueous sodium hydroxide solution to 33.23 g of L-alanine. The temperature was raised to 35 ° C., and 81.6 g of lauroyl chloride and a 27% aqueous sodium hydroxide solution were simultaneously added dropwise while maintaining the pH at 11. After completion of the reaction, the acylation reaction solution was neutralized with 75% sulfuric acid, the pH was adjusted to 2, and the aqueous layer was removed by oil separation at 70 ° C. Water (203 g) was poured into the obtained oil layer, and after stirring, oily separation was performed. The oil layer was dried under reduced pressure (50 ° C., reduced pressure) to obtain 94.32 g of a white crystalline substance (N-lauroyl-L-alanine).

<Example 1>
A predetermined amount of N-acylamino acid was measured, and lauric acid was measured to be 0.1% by weight of the total amount, placed in a 50 ml vial, and then an oil was added. The mixture was heated to 100 ° C. while stirring to completely dissolve the N-acylamino acid, and then allowed to cool to room temperature, and the state (including feel) of the obtained gel composition was confirmed. The results are shown in Table 1.

Ｎ−ラウロイル−Ｌ−アラニンのみが５０℃、１週間という保存条件で唯一安定であった。 <Example 2>
N-acylamino acid was measured in a predetermined amount (so that the N-acylamino acid concentration in the target gel composition was 5%), lauric acid was measured to be 0.5% by weight of the total amount, and 30 ml. The oil was then added. The mixture was heated to 90 to 100 ° C. with stirring to completely dissolve the N-acylamino acid, and then allowed to cool to room temperature, and the state (including feel) of the resulting gel composition was confirmed. The results are shown in Table 2.

Only N-lauroyl-L-alanine was only stable under storage conditions of 50 ° C. and 1 week.

<Example 3>
N-acylamino acid was measured in a predetermined amount (so that the N-acylamino acid concentration in the target gel composition was 3%), lauric acid was measured to be 0.4% by weight of the total amount, and 30 ml. The oil was then added. The mixture is heated to 90 to 100 ° C. with stirring to completely dissolve the N-acylamino acid, and then allowed to cool to room temperature with vigorous stirring or without stirring, and the resulting gel-like composition (including feel) It was confirmed. The results are shown in Table 3.

専門パネラー５名にて評価した結果、実施例４で得られるクリーム状ゲルは、比較例１で得られるクリーム状ゲルよりも外観がよりクリーミーで、かつ皮膚塗布時の滑らかさに優れていることが判明した。 <Example 4>
A predetermined amount of N-acylamino acid and fatty acid was weighed and placed in a 50 ml vial, and then an oil was added. The mixture is heated to 90 to 100 ° C. to completely dissolve the N-acylamino acid, and then allowed to cool to room temperature with strong stirring or without stirring. Was evaluated by a specialized panel. In the evaluation, according to the following items, the average score is 2.6 or more, ２．２, 2.2 to 2.6 is ○, 1.8 to 2.2 is ○, and 1.8 or less is ×. The results are shown in Table 4.

Evaluation item [preference of appearance]
3: Uniform and smooth creamy form 2: Almost uniform cream form, but some solid precipitates are observed 1: Solid precipitates are observed

[Extenderability during skin application]
3: Very smooth 2: Smooth but somewhat rough 1 1: Clearly rough

As a result of evaluation by five professional panelists, the cream gel obtained in Example 4 is more creamy in appearance than the cream gel obtained in Comparative Example 1 and has excellent smoothness when applied to the skin. There was found.

<Example 5: Production of gel composition for cosmetics>
Put 0.2325 g of N-lauroyl-L-alanine obtained in Production Example 1, 0.0175 g of lauric acid and 4.75 g of dimethicone (“SH200C” manufactured by Toray Dow Corning Silicone Co., Ltd.) in a 50 ml vial. It was heated to 90 ° C. with stirring and dissolved. It was cooled to room temperature with vigorous stirring by hand, and it was confirmed that the whole gelled.
The resulting gel-like composition is a cloudy to translucent cream-like composition that, when applied to the skin, does not feel sticky or occluded, and has excellent spreadability. It turns out that it is excellent as.

<Prescription Example 1; Hand cream>
Liquid paraffin 30wt%
Dimethicone 65wt%
Lauroyl-L-alanine 4.65 wt%
Lauric acid 0.35wt%
(* 1: "Molecos P55" made by Matsumura Yushi)
(* 2: “SH200C” manufactured by Toray Dow Corning Silicone Co., Ltd.)
When a hand cream was prepared according to the above formulation, it exhibited a finer creaminess from white turbidity to translucency, and showed a smooth texture with no stickiness or blockage.

Claims (8)

It contains at least one N-acylamino acid (A) represented by the following general formula (1), at least one oily base (B), and at least one higher fatty acid (C). A gel composition.

(Wherein R ₁ represents a linear or branched saturated hydrocarbon group having 1 to 25 carbon atoms, or an unsaturated hydrocarbon group which may contain an aromatic ring, and X is aliphatic or aromatic. Represents an α-, β-, or γ-amino acid. The gel composition according to claim 1, wherein the N-acylamino acid (A) is an N-acyl neutral amino acid. The gel composition according to any one of claims 1 to 2, wherein the N-acylamino acid (A) is N-acyl-L-alanine. The N-acylamino acid (A) is N-2-ethylhexanoyl-L-alanine, N-capryloyl-L-alanine, N-caproyl-L-alanine, N-lauroyl-L-alanine, N-myristoyl-L. The gel composition according to any one of claims 1 to 3, which is N-acyl-L-alanine selected from -alanine and N-palmitoyl-L-alanine. The gel composition according to any one of claims 1 to 4, wherein the N-acylamino acid (A) is N-lauroyl-L-alanine. The gel composition according to any one of claims 1 to 5, wherein the oily base (B) is a hydrocarbon oil or a silicone oil. The manufacturing method of the gel-like composition in any one of Claims 1-6 including the following processes.
1) Step of uniformly heating and dissolving gelling agent, oily base, and other additives 2) Step of stirring and cooling A cosmetic comprising the gel composition according to any one of claims 1 to 6.