JP2006075152A5 - - Google Patents

Claims (9)

A method for inhibiting migration of astroglial cells excluding human in vivo, which comprises inhibiting expression of a Lib gene and / or inhibiting a function of a protein encoded by the gene. A method for inhibiting the migration of astroglial cells excluding human in vivo, comprising using an expression inhibitor of Lib gene and / or a function inhibitor of a protein encoded by the gene. A method for inhibiting migration of astroglial cells excluding human living bodies, comprising using an antisense polynucleotide of a Lib gene. A method for inhibiting migration of astroglial cells excluding human living bodies, comprising using siRNA or shRNA that inhibits expression of a Lib gene. A method for identifying a compound that inhibits the cell migration ability of an astroglial cell of a protein encoded by a Lib gene, which enables interaction between a cell expressing the Lib gene and a certain compound (test compound) The cell is contacted with the test compound under conditions, and then the cell migration is measured under conditions where the cell migration can be measured, and the cell migration and test in the presence of the test compound are measured. By comparing the movement of the cell in the absence of the compound and detecting a change in the movement of the cell, it is determined whether the test compound inhibits the cell migration ability of the protein encoded by the Lib gene. The identification method characterized by doing. An astroglial cell migration inhibitor comprising an effective amount of an antisense polynucleotide of the Lib gene. An astroglial cell migration inhibitor comprising an effective amount of siRNA or shRNA that inhibits expression of the Lib gene. A astroglial cell migration inhibitor comprising an effective amount of an antisense polynucleotide containing a base sequence complementary to the base sequence set forth in SEQ ID NO: 1 in the Sequence Listing or a part of the complementary base sequence. An astroglial cell migration inhibitor comprising an effective amount of siRNA or shRNA that inhibits expression of a Lib gene comprising the base sequence set forth in SEQ ID NO: 1 in the Sequence Listing.