JP2006072927A - Preserved cell management system - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a preserved cell management system supporting extraction and shipping of preserved cells for obtaining a tooth related cell or a tooth related tissue responding to a request of a hospital, a doctor, or the like. <P>SOLUTION: The preserved cell management system is provided with a database part 5 storing management information of preserved cells for obtaining the necessary tooth related cell or tooth related tissue, a server part 3 retrieving the management information of preserved cells from the database part 5, a management information input part 7 for inputting the management information of preserved cells into the database part 5, and a management information output part 7 of a preserved cell used for obtaining the necessary tooth related cell or tooth related tissue. The server part 3 has a communication means 17 for communicating with a user terminal 9, an information retrieval part 11 for sending a preserved cell selection condition image plane to the user terminal and retrieving management information of the preserved cell corresponding to selection conditions from the database part 5, and a user cell determining means 13 for sending the management information of the preserved cell acquired from the database 5 to the user terminal 9, and sending information determining usage of the preserved cell of the displayed management information to the user terminal 9. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a storage cell management system for using a storage cell for obtaining a tooth-related cell or a tooth-related tissue for a treatment using a tooth-related cell or a tooth-related tissue.

  Preserved cells are stored, and as a system for providing the stored cells as necessary, the stored cell genetic information is stored, and the user can store the cell genetic information. A cell bank system that can be browsed and instructed to obtain necessary cells has been proposed (see, for example, Patent Document 1). Furthermore, in order to use the collected umbilical cord blood for treatment of the collected individual, the name of the user and the information related to the umbilical cord blood collected at the request of the user are stored in the storage information storage means in association with each other. An umbilical cord blood management system that can identify umbilical cord blood corresponding to a person's name has also been proposed (see, for example, Patent Document 2).

JP 2002-27983 A (page 3-7, FIG. 1) Japanese Unexamined Patent Publication No. 2003-141264 (page 6-11, FIG. 1)

  By the way, it is considered to carry out treatment such as regeneration treatment using tooth-related cells and tooth-related tissues. However, in treatment using tooth-related cells and teeth-related tissues, necessary tooth-related cells and Different types of tooth related tissues. Furthermore, the types of cells to be stored to obtain multiple types of tooth-related cells or tissues used in these treatments include not only the tooth-related cells themselves but also dental pulp cells and tooth germ epithelial cells. Other types of teeth-related cells and cells that can be induced to differentiate into tooth-related tissues, tooth-related cells such as mesenchymal stem cells, and cells other than tooth-related cells that can obtain tooth-related tissues is there. Therefore, in order to support the extraction and shipment of preserved cells for obtaining tooth-related cells and tooth-related tissues according to requests from users such as hospitals and doctors, tooth-related cells and teeth provided for treatment are used. Depending on the type of related tissue, a storage cell management system that can extract a necessary type of stored cells from a plurality of types of stored cells is required.

  However, systems such as Patent Document 1 and Patent Document 2 do not consider the storage and provision of a plurality of types of cells, and thus obtain tooth-related cells and tooth-related tissues according to user requests. Therefore, it is difficult to use to support the extraction and shipment of stored cells.

  The subject of this invention is providing the preservation | save cell management system which assists extraction and shipment of the preservation | save cell for obtaining a tooth | gear relevant cell and a tooth relevant tissue according to the request | requirement from users, such as a hospital and a doctor.

  The preserved cell management system of the present invention correlates information on a donor who obtains a preserved cell, information on the type and quantity of the preserved cell, as management information of the preserved cell for obtaining a necessary tooth-related cell or tooth-related tissue. A database unit for storing data, a server unit for retrieving and providing management information on stored cells from the database unit, and providing management information input for entering stored database management information in the database unit And a management information output unit that outputs management information of stored cells used to obtain necessary tooth-related cells or tissue, and the server unit communicates with the user terminal via a communication line. Information to display a screen for entering selection conditions for selecting a storage cell to be used and a storage cell to be used is transmitted to the user terminal and used. Information retrieval means for retrieving and acquiring stored cell management information corresponding to the selection condition input at the terminal from the database unit, and information for displaying the stored cell management information acquired from the database unit The above-described problem is achieved by including a cell-use determining unit that transmits information for displaying a screen for inputting a decision to use a stored cell that displays the management information to the user terminal. Resolve.

  Further, the used cell determining means is configured to receive the information on the use determination from the user terminal and output the management information of the stored cell determined to be used to the management information output unit.

  Further, the information search means of the server unit transmits information for displaying a screen for inputting a necessary tooth-related cell or type of tooth-related tissue to the user terminal as a selection condition for selecting a stored cell to be used. The management information of the type of stored cells that can obtain the type of tooth-related cells or tooth-related tissue input from the user terminal is retrieved from the database unit.

  Furthermore, in addition to the management information of the stored cells, the database unit associates the types of tooth-related cells or tooth-related tissues required in relation to the treatment method and the treatment site with the tooth-related cells or tooth-related tissue types. Stores the types of stored cells necessary for obtaining cells or tooth-related tissues, and the information retrieval means of the server unit inputs a treatment method and a treatment site as selection conditions for selecting the stored cells to be used. Information for displaying the screen is transmitted to the user terminal, and the type of the necessary tooth-related cell or tissue is determined based on the treatment method and the treatment site input at the user terminal. The management information of the stored cells of a type that can obtain tooth-related cells or tooth-related tissues is retrieved from the database unit and acquired.

  In addition to the management information of stored cells, the database unit relates to the necessity of the carrier and the type of carrier when using the carrier as shipping form information when providing the necessary tooth-related cells or tooth-related tissues. When information is stored in association with at least one of a treatment method, a treatment site, a tooth-related cell type, and a differentiation induction condition, and the utilization cell determination unit of the server unit causes the management information output unit to output management information, It is configured to output the shipping form information regarding the necessity of the carrier and the type of the carrier when the carrier is used.

  Furthermore, the use cell determination means of the server unit, when transmitting information for displaying a screen for determining the use of the stored cell displaying the management information to the user terminal, and the necessity of the carrier and when using the carrier In addition, information for displaying a screen for inputting the type of carrier is also transmitted to the user terminal.

  In addition to the management information of stored cells, the database unit also provides information on safety tests performed when providing tooth-related cells or tooth-related tissues obtained from stored cells, treatment methods, treatment sites, and provided tooth-related cells. Alternatively, the information is stored in association with at least one of the types of tooth-related tissues, and when the utilization cell determining means of the server unit causes the management information output unit to output the management information, information related to the safety test is also output.

  Further, the use cell determining means of the server unit transmits the information for displaying the screen for determining the provision of the stored cell displaying the management information to the user terminal, when the tooth related cell or the tooth related obtained from the stored cell is transmitted. Information for displaying a screen for inputting items of a safety test to be performed when an organization is provided is also transmitted to the user terminal.

  In addition to the information on the donor who obtained the stored cells, the information on the type and quantity of the stored cells, the database unit also stores information specifying the location where each stored cell is stored as the management information of the stored cells. The management information stored in association with each other and output to the management information output unit by the use cell determining unit of the server unit includes information for specifying the location where the stored cells to be used are stored.

  Further, the server unit is configured to include a display restriction unit that restricts the management information of the stored cells displayed on the user terminal to a part of the management information of the stored cells stored in the database unit.

  Furthermore, it has an information recording medium that records identification information for identifying a given stored cell for each stored cell, and the database section is information regarding the donor that obtained the stored cell as management information for the stored cell. In addition to the information related to the type and quantity of stored cells, identification information is stored in association with each other.

  In addition to the management information of stored cells, the management information of stored teeth is handled as management information.

  With such a configuration, it is possible to provide a stored cell management system that supports extraction and shipment of stored cells for obtaining tooth-related cells and tooth-related tissues in response to requests from users such as hospitals and doctors.

  ADVANTAGE OF THE INVENTION According to this invention, the preservation | save cell management system which assists the extraction and shipment of the preservation | save cell for obtaining a tooth | gear related cell and a tooth | gear related tissue according to the request | requirement from users, such as a hospital and a doctor, can be provided.

  Hereinafter, an embodiment of a stored cell management system to which the present invention is applied will be described with reference to FIGS. FIG. 1 is a block diagram showing a schematic configuration of a storage cell management system to which the present invention is applied. FIG. 2 is a block diagram for explaining an outline of an example of a business using a preserved cell management system to which the present invention is applied. FIG. 3 is a diagram illustrating an example of a work flow such as collection, storage, provision, and treatment of tooth-related cells. FIG. 4 is a diagram illustrating an example of management information items. FIG. 5 is a flowchart showing the operation of the storage cell management system to which the present invention is applied. FIG. 6 is a diagram illustrating an example of a login screen displayed on the user terminal. FIG. 7 is a diagram illustrating an example of a selection condition input screen displayed on the user terminal. FIG. 8 is a diagram showing an example of a screen for determining a list of management information such as tooth-related cells acquired from the database unit displayed on the user terminal and the tooth-related cells to be used. FIG. 9 is a diagram illustrating an example of information output to a management information output unit such as a cell storage manager terminal.

  When regenerative treatment using a tooth-related cell or a tooth-related tissue is performed, a tooth-related cell or a cell for obtaining a tooth-related tissue necessary for the treatment is necessary. However, it is difficult to collect tooth-related cells and cells for obtaining tooth-related tissues necessary for treatment from healthy teeth. This is because cells of erupted teeth, such as dental pulp and periodontal ligament, have a relatively low regenerative capacity, and thus collecting healthy cells may damage healthy teeth. Therefore, the collection of cells to obtain tooth-related cells and teeth-related tissues necessary for the treatment, when collecting cells from the tooth, erupted teeth, impacted teeth and tooth germs, which had to be removed for treatment, etc. It is considered to carry out from extracted teeth obtained by extracting excess teeth.

  However, when cells are extracted from the extracted tooth, when a tooth-related cell or tooth-related tissue is required for treatment, an extracted tooth can be obtained that can collect the tooth-related cell or cell for obtaining the tooth-related tissue. The timing when tooth-related cells and tissues are required for treatment does not coincide with the timing when extracted teeth are obtained to collect teeth-related cells and cells for obtaining tooth-related tissues There are more. For this reason, various cells attached to the extracted tooth are collected as much as possible from the extracted tooth extracted from the donor for treatment, etc., sorted and stored for each donor and type, and the tooth is used for treatment. When related cells or dental related tissues are needed, it is considered to select and use the necessary types of cells from the stored cells, that is, the stored cells.

  In this way, various cells are collected from previously obtained extracted teeth, sorted and stored, and the necessary types of stored cells are extracted when necessary, so that the extracted stored cells can be used for treatment. The tooth-related cells and tooth-related tissues necessary for the preparation can be obtained when necessary. However, the collection, classification, and storage of cells from such extracted teeth and the extraction of necessary types of stored cells are complicated operations that are difficult for hospitals and doctors to carry out independently. Therefore, a business is considered in which the extracted tooth is collected from a hospital or a doctor, the cells are collected, classified and stored from the collected extracted tooth, and the necessary types of stored cells are extracted and provided.

  When conducting such a business, the business operator sorts and stores the cells collected from the extracted teeth collected from hospitals and doctors in each region for each type or donor, and stores the necessary types from the stored cells. It is necessary to manage information about stored cells in order to extract and provide cells. Furthermore, in most cases, the location of the business that stores the stored cells is far from the location of the hospital where the treatment is performed, and it is as quickly as possible in response to requests from users such as hospitals and doctors. It is necessary to take out necessary tooth-related cells from stored cells, package them, and ship them. Therefore, in order to conduct business such as collecting extracted teeth from hospitals, doctors, etc., collecting, classifying, storing cells from the extracted extracted teeth, and extracting and providing the necessary types of cells from the stored cells In addition, there is a need for a storage cell management system that supports extraction and shipment of stored cells for obtaining tooth-related cells and tooth-related tissues in response to requests from users such as hospitals and doctors.

  Therefore, as shown in FIG. 1, the storage cell management system of this embodiment includes a server unit 3, a database unit 5, a cell storage manager terminal 7 installed in a business office of the cell storage manager 1, and Consists of tooth-related cells and teeth-related tissues obtained from stored cells, that is, stored cells, and a user terminal 9 installed at the hospital or the like for use by doctors who receive provision of stored teeth, that is, stored teeth. ing. The cell preservation manager 1 collects and stores tooth-related cells and cells for obtaining tooth-related tissues and teeth from hospitals and stores tooth-related cells obtained by using the preserved cells according to the user's request. Tooth-related tissues and businesses that provide teeth.

  The server unit 3 determines the use of the storage cell and the stored tooth extracted by the information search unit 1 and the information search unit 1 for searching and acquiring the management information of the stored cell and the stored tooth stored in the database unit 5. In addition, there is a program that gives the server unit 3 the function of the used cell determining means 13 that outputs the management information of the stored cells and stored teeth determined to be used to the cell storage manager terminal 7. In addition, the server unit 3 has a program that gives the server unit 3 the function of the display restriction unit 14 that restricts the content of the management information of the stored cells and stored teeth displayed on the user terminal 9. Further, the server unit 3 constitutes a program for giving the server unit 3 the function of the communication unit 17 for transmitting and receiving information to and from the user terminal 9 via the communication network 15 such as the Internet, and the communication unit 17. It has communication devices such as a communication circuit and a modem.

  The database unit 5 stores information about stored cells and stored teeth as management information, and is appropriately connected to the server unit 3 and the cell storage manager terminal 7 so as to be able to exchange information. The cell storage manager terminal 7 serves as a management information input unit for inputting management information of stored cells and stored teeth to the database unit 5, and also manages management information of stored cells and stored teeth to be used, and related tooth to be shipped. By displaying information on the form of shipment such as the type of cells and tooth-related tissues and the necessity of carriers, that is, shipment form information, etc. on the monitor of the cell storage manager terminal 7 or making it printable, management information and form It also serves as a management information output unit that outputs information such as information.

  The user terminal 9 is used for inputting selection conditions for selecting a stored cell and a stored tooth to be used, and for determining use of the extracted stored cell and stored tooth. Therefore, as the user terminal 9, if it can transmit and receive information to and from the user terminal 9 via the server unit 3 and the communication network 15, a portable personal computer such as a desktop personal computer installed in a hospital or the like can be used. Various devices such as a portable device such as a telephone, a notebook personal computer, and a PDA can be used.

  The information search means 11 included in the server unit 3 determines and determines search conditions such as the type of stored cells and stored teeth to be searched according to the selection conditions such as the treatment site and the treatment method input at the user terminal 9. Based on the search condition, the information stored in the database unit 5 is searched, and the management information of the stored cells and stored teeth corresponding to the search condition is obtained from the database unit 5. Furthermore, the information search means 11 also functions to determine the number of stored cells to be used based on the size and number of treatment sites.

  The use cell determining means 13 of the server unit 3 uses information for displaying the management information of the stored cells and stored teeth acquired from the database unit 5 and the use of the stored cells and stored teeth displaying the management information on the user terminal 9. Information for displaying a screen for determining the user ID is transmitted to the user terminal 9. Furthermore, when the utilization cell determination means 13 of the server unit 3 receives the information on the determination of provision from the user terminal 9, the management information of the storage cells and storage teeth determined to be used, as well as the shipment form information and implementation It fulfills the function of outputting information on safety tests to be performed to the cell storage manager terminal 7 serving as a management information output unit.

  Further, the display restricting means 14 of the server unit 3 displays the stored cell and stored tooth management information on the user terminal 9, based on the user identification information sent from the user terminal 9, The management information items that can be displayed on the user terminal 9 are determined, and the management information displayed on the user terminal 9 is limited to a part of the management information. For example, stored cells and stored teeth that display management information on the user terminal 9 are collected from a hospital or dentist 19 as a user identified by the user identification information sent from the user terminal 9. If not, do not display information that can identify the donor, such as the donor's name or medical history, or information related to the donor's personal information, or the hospital or dentist 19 that is the user may use stored cells or stored teeth. To avoid displaying information that is not necessary to determine.

  Here, the collection of the cells used to obtain the tooth-related cells and the tooth-related tissues to which the preserved cell management system of this embodiment is applied, the provision of the tooth-related cells and the teeth-related tissues used for the treatment and treatment are performed. An outline of an example of business will be described. As shown in FIG. 2, the cell preservation manager 1 collects, preserves, and stores the preserved cells and the preserved teeth from the hospital, the dentist 19 and the patient and the extracted extracted teeth that serve as the preserved tooth source. It is negotiated with a hospital, a dentist 19 or the like by a contract to provide tooth-related cells, tooth-related tissues, teeth, and the like. By this arrangement, by issuing a user ID and password as user identification information to the hospital, dentist 19, etc., the hospital, dentist 19, etc. will receive the tooth-related cells, tooth-related tissues, and tooth information. In order to receive the provision, the cell storage manager 1 can access the server unit 3.

  As shown in FIGS. 2 and 3, the cell preservation manager 1 collects extracted teeth and the like obtained by treatment from a hospital, a dentist 19, or the like via, for example, a user terminal 9, a telephone, or a fax machine. Receives the request and collects the extracted teeth. At this time, the cell storage manager 1 is given to each cell and tooth to be collected and stored, and is shown as an identification information issuing means for issuing identification information for identifying these cells and teeth. A management number which becomes identification information of the extracted tooth or cell to be collected is issued by a computer for issuing no identification information, etc., and the hospital or dentist 19 who requested the collection is notified. At the hospital, dentist 19, etc., after receiving this management number, the donor is inspected for infectious diseases and the teeth are removed. Thereafter, the hospital, dentist 19 and the like perform, for example, cleaning processing of the extracted tooth and put it in a transfer container used for transfer containing a transfer liquid which is a solution for transferring the extracted tooth. In the transfer container containing the extracted teeth, etc., an IC that records the extracted extracted teeth and the management number that is the identification information of the cells, the hospital and doctor who obtained the extracted teeth, information on the date and time, information on the donor, etc. An information recording medium such as a tag is attached. The transfer container attached with the information recording medium is refrigerated and stored until the cell storage manager 1 comes to collect it.

  When the cell preservation manager 1 collects the extracted tooth stored in the transfer container from the hospital or the dentist 19 or the like, the cell preservation manager 1 performs a cleaning process on the extracted tooth and then removes the extracted tooth in the case of the extracted tooth. The cells are separated from the extracted teeth and are collected according to type. Cells collected from the extracted tooth and other collected cells are subjected to an acceptance test such as a cell activity test. After the acceptance test, each cell is cultured and grown until it reaches a predetermined number of cells, and then placed in a storage container containing a storage solution for each cell type and donor. On the other hand, the tooth itself, that is, the hard tissue of the extracted tooth from which the attached cells are separated is also put into a storage container containing a storage solution for each type and donor. In each storage container, information read from the information recording medium attached to the transfer container, contents information such as the type of cells and teeth, information on the result of the acceptance test, information on culture, and the like were stored. An information recording medium such as an IC tag on which information including the number of cells or the number of teeth is added is attached. A storage container to which an information recording medium such as an IC tag is attached is stored in a refrigerator or a refrigeration apparatus depending on a storage period or the like, or stored in a freezer or a refrigeration apparatus and stored frozen.

  At this time, as shown in FIG. 1, FIG. 3 and FIG. 4, the cell storage manager 1 stores information that becomes management information in the storage cell management system, that is, information for identifying the storage container, and stored cells contained in the storage container. Cell information such as personal information about the donor of the stored tooth and the stored tooth, information about the hospital and doctor who obtained the stored cell and stored tooth, date, etc., stored cell information about the contents such as the type and quantity of the stored cell and stored tooth , Acceptance test information regarding acceptance test results, culture information prior to storage such as the presence or absence of culture prior to storage and the type and passage number of the culture medium when stored, storage information regarding storage temperature, storage start date and time, etc. Is input from the cell storage manager terminal 7 to the database unit 5, and the database unit 5 stores each information in the database unit 5 in association with each other.

  In addition, the input of the information serving as the management information from the cell storage manager terminal 7 is performed by inputting from a keyboard, input by a selection operation on a screen using a mouse, or reading information from an information recording medium such as an IC tag. Any one of input or the like, or a combination of these input methods can be performed.

  On the other hand, when there is a shipping request from a user, that is, a hospital or a dentist 19 using the user terminal 9 of the stored cell management system, the cell storage manager 1 requests the shipping as shown in FIGS. Remove the tooth-related cells, tooth-related tissues, storage cells for obtaining the teeth, and storage containers containing the stored teeth from the refrigerator, refrigerator, freezer or freezer. At this time, if it is stored frozen, it is thawed. The extracted preserved cells are proliferated by culturing to the number of cells according to the shipping request. Furthermore, in order to obtain a shipping form according to the shipping request, differentiation induction into tooth-related cells and tooth-related tissues necessary for treatment, seeding on a carrier, and the like are performed. After the cells are grown to the required number of cells and made into the required shipping form, a safety evaluation test, which is a shipping test, is performed according to the type of tooth-related cells, teeth-related tissues, and teeth to be shipped. The tooth-related cells, tooth-related tissues, and teeth that have passed the shipping test are accommodated in a transfer container containing a transfer liquid and delivered to the hospital or dentist 19 who requested the shipment.

  The hospital or dentist 19 that received the tooth-related cell, tooth-related tissue, or tooth that requested the shipment removes the received tooth-related cell, tooth-related tissue, or tooth from the transfer container and cleans it. The patient is treated with tissue and teeth. The hospital or dentist 19 performs postoperative management of tooth-related cells, tooth-related tissues, and tooth transplantation operations for treatment, and stores the results using the user terminal 9 of the storage cell management system. The cell preservation manager 1 follows the postoperative course and the like.

  Examples of cells collected and stored from the extracted tooth include dental pulp cells, periodontal ligament cells, tooth germ epithelial cells, and the like. Oral mucosal epithelial cells and mesenchymal stem cells that can be differentiated into tooth-related cells are also subject to preservation cells. These preserved cells are classified according to cell types and collected donors, stored in a preservation container, and cryopreserved. For example, dental-related cells or tooth-related tissues used for treatment are differentiated from dental pulp cells, periodontal ligament cells, dental pulp-like tissues, periodontal ligament tissues, oral mucosal epithelium, dental pulp cells and dental germ epithelial cells, and mesenchymal stem cells. Odontoblasts, osteoblasts, cementoblasts, and enamel blasts.

  In the present embodiment, the database unit 5 associates with the treatment method and treatment site, information on the types of tooth-related cells, tooth-related tissues, teeth and the like used for the treatment, and the teeth used for the treatment. Stores information on the shipping form of related cells and tooth-related tissues, information on the presence / absence of use of the carrier, and the type of necessary carrier. Further, the database unit 5 includes information on the types of stored cells necessary for obtaining the tooth-related cells and tooth-related tissues as described above and the contents of the shipping test in association with the types of tooth-related cells and tooth-related tissues. Information such as is stored.

  As for the form of shipment, only tooth-related cells and teeth-related tissues, tooth-related cells and teeth-related tissues in the state of seeding on carriers or teeth, carriers or teeth and tooth-related cells and teeth-related tissues separately, carrier or teeth There are only. When only the tooth-related cells and the tooth-related tissues are shipped, for example, they are shipped in a transfer liquid at a normal temperature or in a frozen state. When shipping tooth-related cells or tooth-related tissues that have been seeded on a carrier or tooth, for example, after culturing tooth-related cells differentiated from preserved cells or preserved cells in the presence of the carrier or teeth, tooth-related cells And tooth-related tissues attached to the carrier or teeth. Transportation for shipment is performed by low-temperature transportation, for example, when shipping at room temperature or in a frozen state. When the carrier or tooth and the tooth-related cells or tooth-related tissues are shipped separately, the related cells or tooth-related tissues are shipped in a frozen state in, for example, a transfer solution, and the receiving hospital or the like receives the carrier or Combine teeth with teeth-related cells and teeth-related tissues.

  Examples of the type and form of the carrier include a granular inorganic porous material such as tricalcium phosphate, and a gel-like protein such as collagen gel and fibrin gel. When a granular inorganic porous material such as tricalcium phosphate is used as the carrier, for example, cells are seeded on the carrier and cultured. When the carrier is a gel-like protein such as fibrin gel, for example, a doctor or the like mixes the tooth-related cells and gel-like carrier separately delivered immediately before use, or cell storage management When adjusting the gel as the carrier in the person 1, the cells are mixed and cultured, and delivered to the hospital or dentist 19. Both carriers are not absorbed when the tooth-related tissue is regenerated.

  Examples of treatment methods include caries treatment, root canal treatment, periodontal treatment, tooth root regeneration, tooth regeneration, and implant with cells. The treatment site is, for example, the left mandibular second premolar, the right maxillary first premolar mesial, the left maxillary canine distal, the left mandibular first molar. In the case of caries treatment, for example, odontoblasts are required as tooth-related cells, and granular tricalcium phosphate is required as a carrier. In the case of root canal treatment, for example, odontoblasts are required as tooth-related cells, and granular tricalcium phosphate is required as a carrier. In the case of periodontal treatment, for example, periodontal ligament cells are required as tooth-related cells, and gel-like fibrin gel is required as a carrier. Furthermore, in order to obtain odontoblasts, as described above, dental pulp cells, mesenchymal stem cells, and the like are required as preserved cells. Thus, once the treatment method and treatment site are known, the type of tooth-related cells and teeth-related tissues to be shipped, the type of stored cells necessary to obtain these tooth-related cells and teeth-related tissues, the differentiation induction method, The presence or absence of a carrier and the type of carrier can be determined if a carrier is required. In addition, knowing the number and size of the treatment area will determine the number of cells required.

  Operation of the storage cell management system of the present embodiment used in the business of collecting and storing cells and teeth to obtain such tooth-related cells and teeth-related tissues and providing necessary tooth-related cells, tooth-related tissues, and teeth And features of the present invention will be described. As shown in FIGS. 1 and 5, the user, such as a hospital or a dentist 19, when a tooth-related cell, a tooth-related tissue, or a tooth is required for treatment, a login screen of the user terminal 9, for example, FIG. In the login screen as shown in FIG. 6, by entering the user ID, password, etc., which becomes the user identification information issued by the cell storage manager 1, and clicking the send button displayed on the screen, User identification information such as a user ID and a password is transmitted from the user terminal 9 to the server unit 3 of the cell storage manager 1 via the communication network 15 (step 101).

  When the server unit 3 of the cell storage manager 1 receives the user identification information such as the user ID and password from the user terminal 9, it confirms that the user identification information user is a contractor. (Step 103), information for displaying on the user terminal 9 a selection condition input screen for selecting the stored cells and stored teeth used by the information search unit 11 of the server unit 3 is displayed in the communication unit 17 and the communication network. 15 to the user terminal 9 (step 105). The user terminal 9 that has received the information for displaying the selection condition input screen from the server unit 3 displays, for example, a selection condition input screen as shown in FIG. 7 on the monitor (step 107).

  On the selection condition input screen as shown in FIG. 7, input items that are selection conditions such as patient information, a treatment method, a treatment site, and a size of the treatment site, and input items such as a desired shipping date and a desired shipping destination are displayed. The The user, such as a hospital or dentist 19, inputs necessary information for each item and clicks a send button displayed on the screen, thereby the server unit possessed by the cell storage manager 1 from the user terminal 9. 3 transmits information such as selection conditions via the communication network 15 (step 109). Note that the number of treatment sites is determined based on the number of selected or input treatment methods, treatment sites, treatment site sizes, and the like. In the screen of FIG. 7, when selecting or inputting two or more treatment sites, a screen for selecting or inputting a treatment method, a treatment site, a size of the treatment site, and the like by clicking an add button. Is displayed.

  In the preserved cell management system of this embodiment, in the patient information, when the patient is a donor of a preserved cell, a donor ID that is identification information for identifying the donor is input, and the patient is not a donor of the preserved cell. In such a case, a button for displaying a screen for inputting information for searching for cells from a donor suitable for the patient is clicked, and necessary information is input to a displayed screen (not shown). Further, in the preserved cell management system of the present embodiment, when selecting the origin of the drug or carrier used for culturing the preserved cell, the drug or carrier used for culturing the preserved cell is derived from a relatively inexpensive animal. A button for displaying a screen for selecting whether to use one or a relatively expensive person is clicked, and the origin is selected on the displayed screen (not shown).

  When the information retrieval unit 11 of the server unit 3 receives information such as the selection condition from the user terminal 9 (step 111), based on the information on the treatment method and treatment site of the selection condition, the tooth-related information necessary for the treatment Information on the management of stored cells from the patient or a donor that matches the patient with the type of stored cells that can determine the type and number of cells and teeth-related tissue and obtain the determined type of tooth-related cells or tissue Is retrieved from the database unit 5 (step 113). In step 113, if a tooth is necessary from the treatment method and treatment site under the selection condition, the type of tooth necessary for treatment is determined based on the information regarding the treatment method and treatment site under the selection condition, and the determined type is stored. The management information of the stored tooth from the donor who matches the patient or the patient with the tooth is retrieved from the database unit 5 and acquired.

  The use cell determining means 13 of the server unit 3 uses the information for displaying stored cell and stored tooth management information acquired from the database unit 5 by the information search means 11 of the server unit 3 as information for displaying on the screen of the user terminal 9, and The data is transmitted from the means 17 to the user terminal 9 via the communication network 15 (step 115). At this time, when there are a plurality of extracted stored cells and stored teeth, the utilization cell determining means 13 of the server unit 3 displays a list of management information of each extracted stored cell and stored tooth as shown in FIG. Information to be displayed on the user terminal 9 is transmitted.

  Furthermore, the used cell determining means 13 of the server unit 3 transmits information for displaying on the user terminal 9 a screen for determining the use of the stored cell on which the management information is displayed. Then, as shown in FIG. 8, the use cell determination means 13 of the server unit 3 performs a check for determining the use of the stored cell in the stored cell and stored tooth management information displayed on the user terminal 9. Information is transmitted to display management information of stored cells and stored teeth on the screen of the user terminal 9 with a determination field for inserting a mark or the like. That is, in this embodiment, the use cell determination means 13 of the server unit 3 uses information for displaying the extracted stored cell and stored tooth management information on the user terminal 9 and the stored cell displaying the management information. The information for displaying the screen for determining on the user terminal 9 is transmitted in a state included in one piece of information.

  At this time, the display restriction unit 14 of the server unit 3 determines items of management information that can be transmitted to the user terminal 9 based on the received user identification information such as the user ID from the user terminal 9. If necessary, only a part of the management information is transmitted as management information to be displayed on the user terminal 9.

  The user terminal 9 that has received the information for displaying the screen for determining the use of the stored cell that has displayed the management information is displayed, and the management information of the stored cell and the stored tooth extracted from the server unit 3 is displayed. For example, a list of stored cell and stored tooth management information as shown in FIG. 8 is displayed on the monitor (step 117). As shown in FIGS. 1 and 5, the user, such as a hospital or dentist 19, confirms the contents of the management information and determines the stored cells and stored teeth to be used from the list of management information. Click the check box to enter the usage decision attached to the management information of cells and stored teeth, and put a check mark. And the preservation | save cell and preservation | save tooth which utilization was decided via the communication network 15 are specified to the server part 3 which the cell preservation | save administrator 1 has from the user terminal 9 by clicking the transmission button currently displayed on the screen. Information on the use decision is transmitted (step 119).

  Even when there is one extracted stored cell or tooth cell, when the stored cell or stored tooth whose management information is displayed is used, the management information of the stored cell or stored tooth is similarly attached. Click in the check box to enter a usage decision and place a check mark. Then, by clicking the transmission button displayed on the screen, the user terminal 9 determines the use of the stored cells and stored teeth via the communication network 15 from the user terminal 9 to the server unit 3 of the cell storage manager 1. Information is sent.

  When the use cell determination means 13 of the server unit 3 receives the use decision information from the user terminal 9 (step 121), based on the use decision information, based on the use decision information, the stored cells and the stored tooth In addition to management information, a list of information related to shipping processing, such as tooth-related cells to be shipped, tooth-related tissues, information on tooth types, shipping form information, information on the contents of shipping tests, shipping date / time and shipping destination information, Information for displaying a screen for changing a preset shipping process on the user terminal 9 is transmitted from the communication means 17 to the user terminal 9 via the communication network 15 (step 123). Also at this time, the display restriction unit 14 of the server unit 3 determines items of management information that can be transmitted to the user terminal 9 based on the received user identification information such as the user ID from the user terminal 9. If necessary, only a part of the management information is transmitted as management information to be displayed on the user terminal 9.

  The user terminal 9 that has received information for displaying a list of information regarding management information and shipping processing from the server unit 3 and information regarding shipping processing, and a screen for changing a shipping processing set in advance, For example, a screen with buttons for displaying a screen for changing a preset shipping process is displayed on the monitor in a list of stored cell and stored tooth management information and shipping process information as shown in FIG. (Step 125). The user, such as a hospital or dentist 19, confirms the stored cells and stored teeth that have been determined to be used, the contents of the shipping process, the shipping date and time, etc., and changes the shipping process contents and shipping date. Click the item change button to display a change screen (not shown) for inputting the change contents, and input necessary contents on the change screen.

  The user, such as a hospital or dentist 19, confirms the management information, information related to shipping processing, shipping date, shipping destination, etc., and if there are no problems, clicks the delivery decision button displayed on the screen. As a result, information on the delivery decision from the user terminal 9 to the server unit 3 of the cell storage manager 1 via the communication network 15, the management information decided to be delivered, information on the shipping process, the shipping date, the shipping destination The information regarding the contents is transmitted (step 127).

  When the use cell determination means 13 of the server unit 3 receives the delivery decision information from the user terminal 9, the management information determined for the received delivery, the information related to the shipping process, the date of shipment, the shipping destination, etc. Based on the information, the management information of the stored cells and stored teeth determined to be used, and the information regarding the shipping process, the shipping date and time, the shipping destination, etc. are output from the server unit 3 to the cell storage manager terminal 7 (step 129). The cell storage manager terminal 7 displays management information determined to be delivered from the server unit 3, information on shipping processing, information on contents such as shipping date and time, and shipping destination on a monitor or the like. At this time, the storage cell and stored tooth management information output to the cell storage manager terminal 7 includes information for specifying the storage cell to be used and the location where the stored tooth is stored, and the cell storage manager The terminal 7 also displays information indicating the storage location of the storage cells and storage teeth determined to be used from the server unit 3 on a monitor or the like.

  The information displayed on the monitor of the cell storage manager terminal 7 and the information printed from the cell storage manager terminal 7 become shipping instruction information and shipping instructions, and the cell storage manager 1 sends the shipping instruction information and the shipping instructions. In accordance with the instructions, the stored cells and stored teeth are removed from the storage location, thawed, cultured for proliferation and differentiation induction of the stored cells, seeded on a carrier, shipping test, packaging, and the like.

  In such a preserved cell management system of this embodiment, as the management information of the preserved cells for obtaining the necessary tooth-related cells or tooth-related tissues, information on the donor that obtained the preserved cells, the type and quantity of the preserved cells A database unit 5 for storing information in association with each other; a server unit 3 for retrieving management information of stored cells from the database unit 5 to obtain and providing the management information from the database unit 5; 5 includes a cell storage manager terminal 7 that also serves as a management information input unit for inputting data to 5 and a management information output unit for outputting management information of stored cells used for obtaining necessary tooth-related cells or tooth-related tissues. ing.

  Furthermore, the server unit 3 displays a screen for inputting a selection condition for selecting a storage cell to be used and a communication unit 17 that enables communication with the user terminal 9 via the communication network 15 that is a communication line. Information search means 11 for transmitting information to the user terminal 9 and searching for and acquiring stored cell management information corresponding to the selection condition input at the user terminal 9 from the database unit 5. Information for displaying the acquired storage cell management information is transmitted to the user terminal 9, and information for displaying a screen for inputting a decision to use the storage cell displaying the management information is displayed. Cell utilization means 13 for transmitting to

  For this reason, depending on the content of treatment, the type of tooth-related cells and teeth-related tissues required differs, and the type of stored cells required to obtain the tooth-related cells and teeth-related tissues required for treatment differ, It becomes possible to extract and provide stored cells necessary for treatment from a plurality of types of stored cells. Therefore, it is possible to provide a stored cell management system that supports extraction and shipment of stored cells for obtaining tooth-related cells and tooth-related tissues in response to requests from users such as hospitals and doctors.

  Furthermore, in the preserved cell management system of the present embodiment, the user terminal 9 installed in a hospital or the like can extract the preserved cells necessary for treatment, determine the preserved cells to be used, request shipping, etc. In response to requests from users such as doctors and doctors, necessary tooth-related cells can be taken out from stored cells, packaged, and shipped as quickly as possible.

  Furthermore, in the stored cell management system of the present embodiment, the used cell determining unit 13 receives the information on the use determination from the user terminal 9 and uses the management information of the stored cell determined to be used as the management information output unit. Output to the cell storage manager terminal 7. For this reason, the cell storage manager 1 can take out necessary storage cells and perform processing for shipping according to the management information displayed or printed on the cell storage manager terminal 7.

  In addition, in the stored cell management system of the present embodiment, the database unit 5 indicates the type of tooth-related cells or tooth-related tissues necessary in association with the treatment method and the treatment site in addition to the management information of the stored cells. Alternatively, the type of stored cell necessary for obtaining the tooth-related cell or the tooth-related tissue is stored in association with the type of the tooth-related tissue. And the information search means 11 of the server part 3 transmits the information for displaying the screen which inputs a treatment method and a treatment site to the user terminal 9 as selection conditions for selecting the preservation | save cell to utilize, and uses it. Based on the treatment method and treatment site input at the person's terminal 9, the type of necessary tooth-related cells or tooth-related tissues is determined, and the type of storage that can obtain the determined type of tooth-related cells or tooth-related tissues Cell management information is retrieved from the database unit 5 and acquired. This eliminates the need for a user, such as a hospital or dentist 19, to determine the type of cells required from the treatment method and request shipping, thereby improving the convenience for the user.

  However, although the convenience is reduced, the database unit 5 does not store information for specifying the type of stored cells required from the treatment method or treatment site, and the information search means 11 of the server unit 3 does not store the treatment method or It can also be set as the structure which does not have a function which specifies the kind of preservation | save cell utilized based on a treatment site | part. In this case, the information search means 11 of the server unit 3 has a function of transmitting information for displaying a screen for inputting the type and number of cells to be used as shown in FIG. It is set as the structure which has.

  Furthermore, in the preserved cell management system of the present embodiment, the database unit 5 uses the carrier information as shipping form information when providing necessary tooth-related cells or tooth-related tissues in addition to the management information of the preserved cells, and When a carrier is used, information on the type of carrier is stored in association with at least one of a treatment method, a treatment site, and a type of tooth-related cells. Then, when the cell storage manager terminal 7 serving as the management information output unit outputs the management information, the use cell determining means 13 of the server unit 3 relates to the necessity of the carrier and, when using the carrier, the type of the carrier. Shipment form information is also output. This eliminates the need for a user such as a hospital or dentist 19 to determine the presence or absence of a carrier and the type of carrier required from the treatment method and request shipping, thereby improving the convenience for the user.

  However, although the convenience is reduced, the database unit 5 does not store information for determining the presence or absence of the carrier and the necessary type of carrier from the treatment method or treatment site, and the cell usage determining means 13 of the server unit 3 is not stored. However, it is also possible to adopt a configuration that does not have the function of specifying the presence or absence of a carrier and the type of necessary carrier based on the treatment method or treatment site. In this case, the utilization cell determination means 13 of the server unit 3 has a function of transmitting information for displaying a screen for inputting the presence / absence of a carrier and a necessary carrier type to the user terminal 9. .

  In addition, in the stored cell management system of the present embodiment, the database unit 5 includes information related to safety tests performed when providing tooth-related cells or tooth-related tissues obtained from the stored cells, in addition to stored cell management information. Stored in association with at least one of a treatment method, a treatment site, and a type of tooth-related cell or tissue to be provided. And the utilization cell determination means 13 of the server part 3 outputs also the information regarding a safety test, when making the cell preservation | save administrator terminal 7 used as a management information output part output management information. This eliminates the need for the cell storage manager 1 or a user such as a hospital or dentist 19 to decide items for the safety test, thereby improving the convenience of the cell storage manager or the user.

  However, although the convenience is reduced, the database unit 5 stores information for determining a necessary safety test item from at least one of a treatment method, a treatment site, and a type of tooth-related cells or tooth-related tissues to be provided. The use cell determination means 13 of the server unit 3 does not have a function of specifying a safety test item based on at least one of the treatment site and the type of tooth-related cells or tooth-related tissues to be provided. It can also be configured.

  Furthermore, in the preserved cell management system of the present embodiment, the database unit 5 stores information specifying the location where each preserved cell is preserved in association with each other as the preserved cell management information. Then, the management information that the cell storage means 13 of the server unit 3 outputs to the cell storage manager terminal 7 serving as the management information output unit includes information that specifies the location where the storage cells to be used are stored. For this reason, the cell preservation | save administrator 1 can take out the preservation | save cell to utilize easily.

  In addition, in the stored cell management system of the present embodiment, the server unit 3 limits the management information of the stored cells displayed on the user terminal to a part of the management information of the stored cells stored in the database unit 5. Display limiting means 14 is provided. For this reason, the user terminal 9 can display only information necessary for extraction of stored cells to be used, etc., and leakage of information requiring attention in handling such as information that can specify a donor and personal information such as a medical history Can be prevented.

  Furthermore, the storage cell management system of the present embodiment has an IC tag or the like as an information recording medium in which identification information for identifying the storage cells and storage teeth given to each storage cell and storage teeth is recorded. is doing. Then, the database unit 5 stores this identification information as one piece of management information for stored cells and stored teeth. Therefore, by comparing the identification information of the stored cells and stored teeth that have been determined to be used with the identification information recorded on an information recording medium such as an IC tag attached to the storage container, the stored cells and stored teeth may be mistaken. Can be suppressed.

  Furthermore, in the storage cell management system of this embodiment, the management information of the stored tooth is handled as management information as well as the management information of the storage cell, so that the collected tooth is stored together with the provision of the tooth-related cells and the tooth-related tissue. Can assist in providing preserved teeth.

  Moreover, in this embodiment, although the server part 3 has illustrated the case where it comprises as one unit, the information search means 11, the utilization cell determination means 13, the display restriction means 14, the communication means 17, etc. are separated. It can also be composed of a plurality of units such as a computer. On the other hand, although the server part 3, the database part 5, and the cell preservation | save manager terminal 7 have illustrated the case where it comprises as a separate unit, they can also be comprised as one unit. As described above, the server unit 3, the database unit 5, the management information input unit, the management information output unit, and the like included in the cell storage manager 1 can have various configurations as long as these functions are performed.

  In the present embodiment, the management information output unit is the cell storage manager terminal 7 installed together with the server unit 3 and the database unit 5. However, when the server unit 3 or the database unit 5 is located away from the cell storage location, a device or the like serving as a management information output unit is installed at the cell storage location, and the cell usage determining means of the server unit 3 13 outputs the management information of the stored cells to the management information output unit installed at the cell storage location via an appropriate communication line or wiring. As a result, even when the server unit 3 or the database unit 5 is located away from the cell storage location, it is possible to instruct the storage location to take out the stored cells and stored teeth and to process the shipment, such as hospitals and doctors. In response to a request from the user, necessary tooth-related cells can be taken out from the stored cells, packaged, and shipped as quickly as possible.

  Furthermore, when the cells are stored in an automated storage facility that automatically transports and removes the storage container to and from the storage location, the used cell determining means 13 of the server unit 3 performs such storage. If information that specifies the storage location of stored cells and stored teeth is output to the computer that manages the facilities, the removal of stored cells and stored teeth in automated storage facilities can be expedited. .

  In this embodiment, the communication network 15, for example, a public network or the Internet is used as a communication line. However, the server unit 3 and the user terminal 9 are connected via a dedicated communication line. You can also Furthermore, the communication line can be configured by wire or wireless.

  Thus, the present invention is not limited to the system configuration of the present embodiment, and can be formed in various configurations.

It is a block diagram which shows schematic structure of one Embodiment of the preservation | save cell management system to which this invention is applied. It is a block diagram explaining the outline of an example of the business using the preservation | save cell management system to which this invention is applied. It is a figure explaining an example of work flows, such as collection, preservation, offer, and treatment of tooth related cells. It is a figure which shows an example of the item of management information. It is a flowchart which shows operation | movement of one Embodiment of the preservation | save cell management system formed by applying this invention. It is a figure which shows an example of the login screen displayed on a user terminal. It is a figure which shows an example of the selection condition input screen displayed on a user terminal. It is a figure which shows an example of the screen which determines the list of management information, such as a tooth related cell acquired from the database part displayed on a user terminal, and the tooth related cell to be used. It is a figure which shows an example of the information output to management information output parts, such as a cell preservation | save manager terminal. It is a figure which shows another example of the selection condition input screen displayed on a user terminal.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Cell preservation | save manager 3 Server part 5 Database part 7 Cell preservation | save manager terminal 9 User terminal 11 Information retrieval means 13 Use cell determination means 14 Display restriction means 15 Communication network 17 Communication means 19 Hospital and dentist

Claims (8)

A database unit for storing information related to a donor who obtained the stored cells and information related to the type and quantity of the stored cells as management information of the stored cells for obtaining the necessary tooth-related cells or tooth-related tissues, and the database unit A server unit for searching for and providing stored cell management information from the database unit, a management information input unit for inputting stored cell management information to the database unit, and necessary tooth-related cells Or a management information output unit that outputs management information of stored cells used for obtaining a tooth-related tissue,
The server unit includes communication means for enabling mutual communication with a user terminal via a communication line, and information for displaying a screen for inputting a selection condition for selecting a stored cell to be used. And the information search means for searching and acquiring stored cell management information corresponding to the selection condition input at the user terminal from the database unit, and the stored cell management information acquired from the database unit are displayed. Storage cell having means for transmitting information to the user terminal and transmitting information for displaying a screen for inputting a decision to use the stored cell displaying the management information to the user terminal Management system. In addition to the management information of stored cells, the database unit associates the type of tooth-related cells or tooth-related tissues necessary in association with the treatment method and the treatment site, and associates the tooth-related cells with the types of tooth-related cells or tooth-related tissues. Alternatively, stored cell types necessary for obtaining a tooth-related tissue are stored, and the information search means of the server unit inputs a treatment method and a treatment site as selection conditions for selecting a stored cell to be used. The information for displaying the screen is transmitted to the user terminal, the type of the necessary tooth-related cell or tooth-related tissue is determined based on the treatment method and the treatment site input at the user terminal, and the type of the determined type The storage cell management system according to claim 1, wherein management information of a stored cell of a type capable of obtaining a tooth-related cell or a tooth-related tissue is retrieved from the database unit. . In addition to the management information of stored cells, the database unit provides information on the necessity of the carrier and the type of carrier when using the carrier as shipping form information when providing the necessary tooth-related cells or tooth-related tissues. Is stored in association with at least one of a treatment method, a treatment site, a tooth-related cell type, and a differentiation inducing condition, and the use cell determining means of the server unit outputs management information to the management information output unit The storage cell management system according to claim 1 or 2, characterized in that shipping necessity information regarding the necessity of the carrier and the type of carrier when the carrier is used is also output. The database unit includes, in addition to the management information of stored cells, information related to a safety test performed when providing a tooth-related cell or a tooth-related tissue obtained from the stored cell, a treatment method, a treatment site, and a provided tooth-related cell or Stored in association with at least one type of tooth-related tissue, and when the utilization cell determining means of the server unit outputs management information to the management information output unit, information related to a safety test is also output. The preservation | save cell management system of any one of Claims 1 thru | or 3 characterized by these. The database unit associates information specifying the location where each stored cell is stored, in addition to information regarding the donor who obtained the stored cell, information regarding the type and quantity of the stored cell, as management information of the stored cell. The management information that is stored in the management information and output to the management information output unit by the cell-use determining unit of the server unit includes information that specifies a location where the stored cells to be used are stored. The preserved cell management system according to any one of 1 to 4. The said server part has a display restriction means which restrict | limits the management information of the preservation | save cell displayed on a user terminal to a part of management information of the preservation | save cell stored in the said database part. The preservation | save cell management system of any one of thru | or 5. An information recording medium on which identification information for identifying the stored cell given to each stored cell is recorded, and the database unit stores the stored cell as the stored cell management information as the stored cell management information; 7. The stored cell according to any one of claims 1 to 6, wherein the identification information is stored in association with each other in addition to information on the donor obtained, and information on the type and quantity of the stored cell. Management system. The preserved cell management system according to any one of claims 1 to 7, wherein, in addition to the preserved cell management information, the preserved tooth management information is also handled as the admin information.

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