JP2006055609A - Induction heated body for thermotherapy - Google Patents

Induction heated body for thermotherapy Download PDF

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JP2006055609A
JP2006055609A JP2004272583A JP2004272583A JP2006055609A JP 2006055609 A JP2006055609 A JP 2006055609A JP 2004272583 A JP2004272583 A JP 2004272583A JP 2004272583 A JP2004272583 A JP 2004272583A JP 2006055609 A JP2006055609 A JP 2006055609A
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thermotherapy
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cancer cell
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Seiichi Takagi
征一 高木
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Abstract

<P>PROBLEM TO BE SOLVED: To provide an induction heated body for thermotherapy which can extinguish cancer cells by magnetic induction heating after magnetic fine particles with monoclonal antibodies are injected into a human body and incorporated into the cancer cells. <P>SOLUTION: The position of the magnetic fine particles incorporated into the cancer cells is confirmed by a supersensitive magnetic sensor. The location is aligned with the central position of an electromagnetic coil generating an electrostatic magnetic field. The added magnetic fine particles are gathered by the electrostatic magnetic field, and further excited. Then, they are gathered by the magnetic power of this induction heated body for thermotherapy. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

発明の詳細な説明Detailed Description of the Invention

この発明は、磁性微粒子にモノクローナル抗体を付けて人体に注射し、ガン細胞に磁性微粒子を取り込ませた後に電磁誘導加熱により、ガン細胞を消滅させる治療に関するものである。  The present invention relates to a treatment in which a monoclonal antibody is attached to magnetic particles and injected into a human body, and after the magnetic fine particles are taken into the cancer cells, the cancer cells are extinguished by electromagnetic induction heating.

発明者は特許第１７３３９６６号において前記技術分野において説明した内容の基本特許を取得した。この治療方法についてはその後、ガン細胞への磁性微粒子の取り込み量の増大のための改良案としてリン脂質で磁性微粒子を修飾する方式が特許公開平成９年第１１０７２２により提案されている。
特許第１７３３９６６号 公開特許公報平成９年第１１０７２２号 The inventor has obtained a basic patent having the contents described in the technical field in Japanese Patent No. 1733966. Regarding this method of treatment, a method of modifying magnetic fine particles with phospholipids as an improvement plan for increasing the amount of magnetic fine particles taken up by cancer cells has been proposed in Japanese Patent Publication No. 1999,722.
Japanese Patent No. 1733966 Published Patent Publication No. 1997, No. 110722

前記の治療法はガンを消滅させることを動物実験により、確認されているが臨床試験は未だ行われていない。今後、臨床試験により更に精密に確認をしてゆくことになるが、本治療法は未だ開発過程にある新療法であり、今後の大きな課題は温熱によるガンの消滅を確実にするための更なる改良である。  Although the above-mentioned treatment methods have been confirmed by animal experiments to eliminate cancer, clinical trials have not yet been conducted. In the future, it will be confirmed more precisely by clinical trials, but this treatment is a new therapy that is still in the process of development, and a major challenge in the future is further to ensure the disappearance of cancer due to heat. It is an improvement.

本発明はこのような要請に応えるため、磁性微粒子をリン脂質で修飾し、これにモノクローナル抗体を付けて、これを人体に注射し、ガン細胞に取り込ませた後、更に外部磁場により、ガン細胞の部分に磁性微粒子が集まる磁場勾配とし、磁力によりガン細胞に追加の磁性微粒子を集合させる手段及びガン細胞内に既に取り込まれた磁性微粒子との磁力の作用により、更に磁性微粒子をガン細胞内に取り込ませる手段により、治療効果を改善するものである。  In order to meet such demands, the present invention modifies magnetic microparticles with phospholipids, attaches monoclonal antibodies thereto, injects them into the human body, incorporates them into cancer cells, and further uses an external magnetic field to produce cancer cells. A magnetic field gradient that collects magnetic particles in the area of the magnetic field, and means for collecting additional magnetic particles in the cancer cell by magnetic force and the magnetic force with the magnetic particles already taken in the cancer cell, further magnetic particles in the cancer cell The effect of treatment is improved by means of taking in.

本発明は以上のような構成であるので、モノクローナル抗体を付けた磁性微粒子をリン脂質で修飾し、モノクローナル抗体の誘導により、磁性微粒子をガン細胞に取り込ませる方式に較べて更に多くの磁性微粒子をガン細胞に集めることが出来るので治療効果を大幅に改善出来る。  Since the present invention is configured as described above, the magnetic fine particles to which the monoclonal antibody is attached are modified with phospholipids, and more magnetic fine particles are added compared to the method in which the magnetic fine particles are incorporated into cancer cells by induction of the monoclonal antibody. Since it can be collected in cancer cells, the therapeutic effect can be greatly improved.

本発明の実施例について、説明図によって基本的な原理を説明する。予めリン脂質で修飾し、モノクローナル抗体を付けた磁性微粒子１を被加熱体６に注射し、ガン細胞３の内部に磁性微粒子１を取り込ませる。次に高感度磁気センサ等により、がん細胞３内に取り込んだ微粒子１の位置を正確に検出する。または原発性のガンであればＭＲＩやＰＥＴの診断でガンの位置を正確に知ることが出来る。次に図２の静磁場を発生する電磁石５の内部に被加熱体６を入れて、ガン細胞３の位置が電磁石５の中央になるようにセットする。次に追加の磁性微粒子２を被加熱体６に注射する。次に電磁石５に通電し、静磁場を発生させる。電磁石５内の静磁場では電磁石５の中央に磁性体を引き寄せる力が働き、がん細胞３の内部の磁性体１に向かって磁性体２が集まる。磁場の印加により、既に細胞の内部に取り込まれた磁性微粒子１を励磁し、ガン細胞の周囲に集合した磁性微粒子２を磁力により引き寄せる。次に電磁誘導加熱により、磁性体１及び磁性体２を電磁誘導加熱する。以上によりがん細胞を磁性体１及び磁性体２により、加熱消滅させる。以上が基本的な原理である。次にこの構成について述べる。磁性微粒子１はマグネタイトをリン脂質で修飾し、モノクローナル抗体を付けて使用することにより、ガン細胞３への取り込み量を増大する方式が実施されている。このマグネタイト微粒子について次のような改善が出来る。即ち、マグネタイト微粒子について酸化処理により、ガンマ酸化鉄微粒子に変化させる。ガンマ酸化鉄微粒子は天然磁石となる性質があるのでこれをキュリーポイントを越える熱処理により、残留磁性を消去する。これをリン脂質で修飾し、モノクローナル抗体を付け、被加熱体６の体内に注射し、ガン細胞３に取り込ませる。がん細胞３に取り込まれたガンマ酸化鉄微粒子に静磁場を印加することにより、ガンマ酸化鉄は天然磁石としての磁性を帯びる。その結果、周囲の磁性微粒子２を集める機能を持つことが出来る。ガンマ酸化鉄の磁性を一旦消去する理由は残留磁性により、マグネタイト微粒子を使用した場合と較べて不都合な挙動発生防止のためである。前記のマグネタイト微粒子の代わりに発熱効率の良いＭｇフエライト微粒子を使用することも出来る。がん細胞に取り込まれた磁性微粒子１に集合させる磁性微粒子２についてはリン脂質で修飾し、モノクロ−ナル抗体を付ける。磁性微粒子２については更に別の方法としてポリエチレンイミン等のプラスの電荷を帯びた物質を付けて細胞内への取り込みの増大を図ることも出来る。更に磁性微粒子２についてはマグネタイトを酸化処理により、ガンマ酸化鉄とし、これを消磁し、ガン患者の体内に注射した後、静磁場により磁場印加して集める方法が出来る。さらに磁性微粒子２は熱効率の良いＭｇフエライトを使用することも出来る。更に磁性微粒子２は超微粒子サイズにおいてのみ強磁性を示すＰｄＦｅ合金微粒子を使用することも出来る。がん細胞内に取り込まれた磁性微粒子１と追加で取り込まれた磁性微粒子２を励磁する事により、電磁石５の治療を終了した後もガン細胞３内の磁性微粒子１及び磁性微粒子２の磁力により、更に周囲の磁性微粒子２の取り込みを継続することが出来る。磁性微粒子１、磁性微粒子２は人体に注射された後、毛細血管に達して細胞周囲を移動するが、毛細血管内の血流速度は毎秒０．０５〜０．１ＣＭと極めて低速度であり、磁界の力の作用により、細胞周囲に引き付けることが可能である。次に電磁石５について述べる。静磁場を発生する電磁石５の内部において、内部の磁性体にはコイルの中央部に引き寄せる電磁力が働く。電磁石５の中央位置においては磁性体はコイル両端からの電磁力が拮抗して釣り合い安定する。電磁石５は静磁場の発生に使用した後、電磁誘導加熱用としても利用出来る。電磁石５は銅線コイルによる電磁石、超伝導電磁石を目的によって使用できる。超伝導電磁石の静磁場は強力であり、静磁場でありながら磁性体に渦電流を発生させ、磁性体を昇温させ、ガン細胞３を消滅させる電磁誘導装置と兼ねることも出来る。本方式は電磁石中央の位置にガン患者のがん細胞位置を合わせることが必要である。ガン細胞の位置はがん細胞内部に取り込まれた磁性微粒子１の位置を高感度磁気センサ等により、検知し、この位置をセットし、次に電磁石５のコイルの中央位置に前記のセットした位置を合わせるよう電磁石５またはベッド３を３次元的に移動可能な構成とする。  The basic principle of the embodiment of the present invention will be described with reference to the explanatory drawings. The magnetic microparticles 1 previously modified with phospholipids and attached with the monoclonal antibody are injected into the heated body 6 and the magnetic microparticles 1 are taken into the cancer cells 3. Next, the position of the fine particles 1 taken into the cancer cells 3 is accurately detected by a high sensitivity magnetic sensor or the like. Or if it is a primary cancer, the position of the cancer can be accurately known by MRI or PET diagnosis. Next, the object 6 to be heated is placed inside the electromagnet 5 that generates the static magnetic field shown in FIG. 2 so that the cancer cell 3 is positioned at the center of the electromagnet 5. Next, additional magnetic fine particles 2 are injected into the heated body 6. Next, the electromagnet 5 is energized to generate a static magnetic field. In the static magnetic field in the electromagnet 5, a force that attracts the magnetic body to the center of the electromagnet 5 works, and the magnetic body 2 gathers toward the magnetic body 1 inside the cancer cell 3. By applying a magnetic field, the magnetic fine particles 1 already taken into the cells are excited, and the magnetic fine particles 2 gathered around the cancer cell are attracted by a magnetic force. Next, the magnetic body 1 and the magnetic body 2 are heated by electromagnetic induction by electromagnetic induction heating. Thus, the cancer cells are extinguished by heating with the magnetic body 1 and the magnetic body 2. The above is the basic principle. Next, this configuration will be described. The magnetic fine particle 1 is modified by magnetite modified with phospholipid and used with a monoclonal antibody to increase the amount of uptake into the cancer cell 3. The following improvements can be made on the magnetite fine particles. That is, the magnetite fine particles are changed to gamma iron oxide fine particles by oxidation treatment. Since the gamma iron oxide fine particles have the property of becoming natural magnets, the residual magnetism is eliminated by heat treatment exceeding the Curie point. This is modified with phospholipid, a monoclonal antibody is attached, injected into the body 6 to be heated, and taken into the cancer cells 3. By applying a static magnetic field to the gamma iron oxide fine particles taken up by the cancer cells 3, the gamma iron oxide becomes magnetized as a natural magnet. As a result, it can have a function of collecting surrounding magnetic fine particles 2. The reason why the magnetism of gamma iron oxide is once erased is to prevent the occurrence of undesirable behavior due to residual magnetism compared to the case where magnetite fine particles are used. Instead of the magnetite fine particles, Mg ferrite fine particles having good heat generation efficiency can be used. The magnetic fine particles 2 to be assembled into the magnetic fine particles 1 taken up by the cancer cells are modified with phospholipids and attached with a monoclonal antibody. As another method for the magnetic fine particles 2, a positively charged substance such as polyethyleneimine can be attached to increase the uptake into cells. Further, for the magnetic fine particles 2, magnetite is oxidized into gamma iron oxide, which is demagnetized, injected into the body of a cancer patient, and then collected by applying a magnetic field with a static magnetic field. Furthermore, the magnetic fine particles 2 can also use Mg ferrite having high thermal efficiency. Furthermore, as the magnetic fine particles 2, PdFe alloy fine particles exhibiting ferromagnetism only in the ultrafine particle size can be used. By exciting the magnetic fine particles 1 taken into the cancer cells and the magnetic fine particles 2 additionally taken in, the magnetic fine particles 1 and the magnetic fine particles 2 in the cancer cells 3 can be magnetized even after the treatment of the electromagnet 5 is finished. Furthermore, the surrounding magnetic fine particles 2 can be continuously taken up. After being injected into the human body, the magnetic fine particles 1 and magnetic fine particles 2 reach the capillaries and move around the cells, but the blood flow velocity in the capillaries is very low, 0.05 to 0.1 CM per second, It can be attracted around the cell by the action of the force of the magnetic field. Next, the electromagnet 5 will be described. Inside the electromagnet 5 that generates a static magnetic field, an electromagnetic force attracted to the central portion of the coil acts on the internal magnetic body. At the center position of the electromagnet 5, the magnetic body is balanced and stabilized by the electromagnetic force from both ends of the coil. The electromagnet 5 can be used for electromagnetic induction heating after being used for generating a static magnetic field. The electromagnet 5 can be an electromagnet made of a copper wire coil or a superconducting electromagnet depending on the purpose. The superconducting electromagnet has a strong static magnetic field, and while it is a static magnetic field, it can also serve as an electromagnetic induction device that generates eddy currents in the magnetic material, raises the temperature of the magnetic material, and extinguishes the cancer cells 3. In this method, it is necessary to align the cancer cell position of the cancer patient with the central position of the electromagnet. The position of the cancer cell is detected by detecting the position of the magnetic fine particle 1 taken into the inside of the cancer cell with a high-sensitivity magnetic sensor or the like, and this position is set, and then the set position is set at the center position of the coil of the electromagnet 5. The electromagnet 5 or the bed 3 is configured to be movable three-dimensionally so as to match.

本発明の実施例の形態に従った一実施例の説明図Explanatory drawing of one Example according to the form of the Example of this invention 本発明に関わる電磁石装置を示す説明図である。It is explanatory drawing which shows the electromagnet apparatus in connection with this invention.

符合の説明Explanation of sign

１：微粒子
２：微粒子
３：細胞
４：印加回路
５：ベッド
６：被加療体
７：電磁石
８：コントローラー1: Fine particle 2: Fine particle 3: Cell 4: Application circuit 5: Bed 6: Treatment target 7: Electromagnet 8: Controller

Claims (5)

磁性微粒子にモノクローナル抗体を取り付け、これをガン細胞内に取り込んで電磁誘導加熱する温熱治療において、電磁石の静磁場によって電磁石の中央位置にガン細胞に取り込んだ磁性微粒子の位置に合わせて磁性微粒子を集め、電磁誘導加熱する温熱治療用被誘導加熱体  In the thermotherapy where a monoclonal antibody is attached to a magnetic microparticle, and this is taken into a cancer cell and electromagnetic induction heating is performed, the magnetic microparticles are collected in the center of the electromagnet by the static magnetic field of the electromagnet according to the position of the magnetic microparticle taken into the cancer cell , Induction heating body for thermotherapy with electromagnetic induction heating 磁性微粒子にモノクローナル抗体を取り付け、これをガン細胞内に取り込んで電磁誘導加熱する温熱治療において、ガン細胞内に取り込んだ磁性微粒子を励磁し、磁力により周囲の磁性微粒子を集める温熱治療用被誘導加熱体  In the thermotherapy where a monoclonal antibody is attached to a magnetic microparticle, and this is taken into a cancer cell and electromagnetic induction heating is performed, the magnetic microparticle taken into the cancer cell is excited and the surrounding magnetic microparticle is collected by magnetic force. body 磁性微粒子にモノクローナル抗体を取り付け、これをガン細胞内に取り込んで電磁誘導加熱する温熱治療においてガン細胞内に取り込んだ磁性微粒子に向かって磁力で集まる励磁した磁性微粒子で構成した温熱治療用被誘導加熱体  Induced heating for thermotherapy consisting of magnetized magnetic particles gathered by magnetic force toward the magnetic microparticles incorporated in the cancer cells in the thermotherapy where the monoclonal antibody is attached to the magnetic microparticles and taken into the cancer cells and electromagnetically heated. body 磁性微粒子にモノクローナル抗体を取り付け、これをガン細胞内に取り込んで電磁誘導加熱する温熱治療において、磁性微粒子を既に取り込んだガン細胞に追加の磁性微粒子を電磁石の磁力により集め、これを電磁誘導加熱する治療システム  In a thermotherapy where a monoclonal antibody is attached to a magnetic microparticle, and this is taken into a cancer cell and electromagnetic induction heating is performed, additional magnetic microparticles are collected by the magnetic force of an electromagnet in the cancer cell that has already incorporated the magnetic microparticle, and this is electromagnetically heated. Treatment system 磁性微粒子にモノクローナル抗体を取り付け、これを細胞内に取り込んで電磁誘導加熱する温熱治療において、ガン細胞に取り込んだ磁性微粒子と追加の磁性微粒子のどちらか一方または双方の磁力により追加の磁性体をガン細胞に集める治療システム  In the thermotherapy in which a monoclonal antibody is attached to a magnetic particle, and this is taken into a cell and electromagnetic induction heating is performed, an additional magnetic substance is gunned by the magnetic force of one or both of the magnetic particle incorporated in the cancer cell and the additional magnetic particle. Treatment system for collecting cells
JP2004272583A 2004-08-23 2004-08-23 Induction heated body for thermotherapy Pending JP2006055609A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014088382A (en) * 2013-11-07 2014-05-15 Kazuhiro Yamamoto Protein and antibody
US9005151B2 (en) 2011-09-07 2015-04-14 Choon Kee Lee Thermal apparatus
JP2015078209A (en) * 2014-12-03 2015-04-23 和浩 山本 Protein and antibody
JP2016185945A (en) * 2016-04-05 2016-10-27 和浩 山本 Protein and antibody
JP2018024666A (en) * 2017-08-08 2018-02-15 和浩 山本 Protein and antibody
JP2019094337A (en) * 2019-01-11 2019-06-20 和浩 山本 Protein and antibody

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9005151B2 (en) 2011-09-07 2015-04-14 Choon Kee Lee Thermal apparatus
JP2014088382A (en) * 2013-11-07 2014-05-15 Kazuhiro Yamamoto Protein and antibody
JP2015078209A (en) * 2014-12-03 2015-04-23 和浩 山本 Protein and antibody
JP2016185945A (en) * 2016-04-05 2016-10-27 和浩 山本 Protein and antibody
JP2018024666A (en) * 2017-08-08 2018-02-15 和浩 山本 Protein and antibody
JP2019094337A (en) * 2019-01-11 2019-06-20 和浩 山本 Protein and antibody

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