JP2006036718A - Method for producing carboxylic acid-4-tetrahydropyranyl ester compound - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for producing a carboxylic acid-4-tetrahydropyranyl ester compound which can produce an industrially suitable carboxylic acid-4-tetrahydropyranyl ester compound in a high yield under mild conditions by a simple method. <P>SOLUTION: This method for producing the carboxylic acid-4-tetrahydropyranyl ester compound comprises reacting 3-buten-1-ol, an aldehyde compound and a carboxylic acid compound. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a method for producing a carboxylic acid-4-tetrahydropyranyl ester compound. Carboxylic acid-4-tetrahydropyranyl ester compounds are useful compounds as raw materials and synthetic intermediates for pharmaceuticals and agricultural chemicals.

Conventionally, as a method for producing a carboxylic acid-4-tetrahydropyranyl ester compound, for example, 2-methyltetrahydropyran-4-ol and butyryl chloride are reacted in dichloromethane in the presence of triethylamine, and the yield is 64%. Discloses a method for producing 4- (2-methyl) tetrahydropyranyl butyrate (see, for example, Patent Document 1). A process for producing 4-tetrahydropyranyl cyanoacetate by reacting a reaction product of cyanoacetic acid and phosphorus pentachloride with diethylhydropyranyl-4-ol in diethyl ether in the presence of N, N-dimethylaniline. It is known (see, for example, Patent Document 2). However, in either method, since 2-methyltetrahydropyran-4-ol or tetrahydropyranyl-4-ol has to be synthesized separately, the reaction is multistep and the reaction system is complicated. There was a problem.
Special Table 2000-500344 International Patent Publication WO98 / 46573

  The object of the present invention is to solve the above-mentioned problems, and to produce a carboxylic acid-4-tetrahydropyranyl ester compound in a high yield by a simple method under mild conditions. It is to provide a process for producing a 4-tetrahydropyranyl ester compound.

  The subject of the present invention is 3-buten-1-ol, a compound of the general formula (1)

(In the formula, R represents a hydrogen atom or a hydrocarbon group.)
And an aldehyde compound represented by the general formula (2a) or (2b)

(In the formula, X ¹ , X ² , X ³ , X ⁴ , X ⁵ , X ⁶ , X ⁷ and X ⁸ represent groups not involved in the reaction. In addition, X ¹ , X ² , X ³ , X ⁴ , X ⁵ , X ⁶ , X ⁷ and X ⁸ may be bonded to each other to form a ring.)
Or a carboxylic acid compound represented by the general formula (3a) or (3b)

(In the formula, X ¹ , X ² , X ³ , X ⁴ , X ⁵ , X ⁶ , X ⁷ , X ⁸ and R are as defined above.)
This is solved by a method for producing a carboxylic acid-4-tetrahydropyranyl ester compound represented by the following formula.

  The present invention provides an industrially suitable method for producing a carboxylic acid-4-tetrahydropyranyl ester compound that can produce a carboxylic acid-4-tetrahydropyranyl ester compound in a high yield by a simple method under mild conditions. I can do it.

  The aldehyde compound used in the reaction of the present invention is represented by the general formula (1). In the general formula (1), R is a hydrogen atom or a hydrocarbon group. Examples of the hydrocarbon group include alkyl groups such as a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, and a hexyl group; Examples thereof include cycloalkyl groups such as cyclopropyl group, cyclobutyl group, cyclopentyl group and cyclohexyl group; aralkyl groups such as benzyl group and phenethyl group; aryl groups such as phenyl group, tolyl group and naphthyl group. These groups include various isomers. These aldehyde compounds may be multimers or acetals.

  The amount of the aldehyde compound used is preferably 1.0 to 5.0 moles, more preferably 1.1 to 2.0 moles per mole of 3-buten-1-ol in terms of aldehyde.

The carboxylic acid compound used in the reaction of the present invention is represented by the general formula (2a) or (2b). In the general formula (2a) or (2b), X ¹ , X ² , X ³ , X ⁴ , X ⁵ , X ⁶ , X ⁷ and X ⁸ are groups not involved in the reaction. For example, hydrogen atom, alkyl group, cycloalkyl group, aralkyl group, aryl group, halogen atom, hydroxyl group, alkoxyl group, alkylthio group, alkylsulfonyl group, arylsulfonyl group, alkylsulfonyloxy group, arylsulfonyloxy group, nitro A group, a cyano group, a carbonyl group or an amino group; X ¹ , X ² , X ³ , X ⁴ , X ⁵ , X ⁶ , X ⁷ and X ⁸ may be bonded to each other to form a ring.

  Examples of the alkyl group include a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group, and a decyl group. These groups include various isomers.

  Examples of the cycloalkyl group include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cycloheptyl group, a cyclooctyl group, and the like.

  Examples of the aralkyl group include a benzyl group, a phenethyl group, and a phenylpropyl group. These groups include various isomers.

  Examples of the aryl group include a phenyl group, a p-tolyl group, a naphthyl group, and an anthranyl group. These groups include various isomers.

  Examples of the halogen atom include a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom.

  As said alkoxyl group, a methoxyl group, an ethoxyl group, a propoxyl group etc. are mentioned, for example. These groups include various isomers.

  Examples of the alkylthio group include a methylthio group, an ethylthio group, and a propylthio group. These groups include various isomers.

  Examples of the alkylsulfonyl group include a methanesulfonyl group, an ethanesulfonyl group, a propylsulfonyl group, a trifluoromethanesulfonyl group, and the like. These groups include various isomers.

  Examples of the arylsulfonyl group include a benzenesulfonyl group, a p-bromobenzenesulfonyl group, a p-toluenesulfonyl group, and the like. These groups include various isomers.

  Examples of the alkylsulfonyloxy group include a methanesulfonyloxy group, an ethanesulfonyloxy group, a propylsulfonyloxy group, and a trifluoromethanesulfonyloxy group. These groups include various isomers.

  Examples of the arylsulfonyloxy group include a benzenesulfonyloxy group, a p-bromobenzenesulfonyloxy group, and a p-toluenesulfonyloxy group. These groups include various isomers.

  The amount of the carboxylic acid compound to be used is preferably 1.0 to 20 mol, more preferably 1.1 to 10 mol, per 1 mol of 3-buten-1-ol.

  The reaction of the present invention is carried out in the presence or absence of a solvent. The solvent used is not particularly limited as long as it does not inhibit the reaction. For example, aromatic hydrocarbons such as benzene, toluene, xylene and mesitylene; halogenated aliphatic hydrocarbons such as chloroform and dichloroethane; acetic acid Carboxylic acid esters such as ethyl, propyl acetate and butyl acetate; Ethers such as tetrahydrofuran, dimethoxyethane and diisopropyl ether; Nitriles such as acetonitrile and propionitrile are preferable, but aromatic hydrocarbons and ethers are preferable. Carboxylic acid esters, more preferably aromatic hydrocarbons are used. These organic solvents may be used alone or in combination of two or more.

  The amount of the solvent used is appropriately adjusted depending on the uniformity and stirring properties of the reaction solution, but is preferably 0 to 50 ml, more preferably 0 to 10 ml, with respect to 1 g of 3-buten-1-ol.

  The reaction of the present invention is carried out, for example, by a method of mixing 3-buten-1-ol, an aldehyde compound and a carboxylic acid compound and reacting them with stirring. The reaction temperature at that time is preferably 10 to 110 ° C., more preferably 20 to 100 ° C., and the reaction pressure is not particularly limited.

  In addition, the carboxylic acid-4-tetrahydropyranyl ester compound as the final product is isolated and purified by a general method such as filtration, concentration, distillation, recrystallization, column chromatography and the like after completion of the reaction.

  Further, the general formula (4) obtained by the reaction of the present invention.

(In the formula, R is as defined above, and n represents an integer of 1 to 3.)
The carboxylic acid-4-tetrahydropyranyl ester compound represented by is a novel compound.

  Next, the present invention will be specifically described with reference to examples, but the scope of the present invention is not limited thereto.

Example 1 (Synthesis of dichloroacetic acid-4-tetrahydropyranyl)
To a 50 ml glass flask equipped with a stirrer, thermometer, reflux condenser and dropping funnel was added 3.29 g of 95% paraformaldehyde (104.1 mmol in terms of formaldehyde) and 39.1 g (303 mmol) of dichloroacetic acid. Heated to 83 ° C. Next, 6.25 g (86.7 mmol) of 3-buten-1-ol was gently added dropwise with stirring, and the mixture was reacted at the same temperature for 2 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure, and 100 ml of toluene and 100 ml of 5% by mass aqueous sodium hydrogen carbonate solution were added to the concentrate for separation. After the aqueous layer was extracted twice with 30 ml of toluene, the organic layer and the extract were combined and concentrated under reduced pressure to give dichloroacetic acid-4-tetrahydropyrani with a purity of 100% (area percentage by liquid chromatography) as light brown crystals. 12.7 g (isolated yield: 68.9%) was obtained.
The physical properties of dichloroacetic acid-4-tetrahydropyranyl were novel compounds represented by the following physical properties.

Melting point: 73-75 ° C
CI-MS (m / e); 213 (M + 1)
¹ H-NMR (CDCl ₃ , δ (ppm)); 1.72 to 1.83 (2H, m), 1.94 to 2.03 (2H, m), 3.54 to 3.63 (2H, m), 3.89 to 3.97 (2H, m), 5.05 to 5.11 (1H, m), 5.95 (1H, s)

Example 2 (Synthesis of dichloroacetic acid-4- (2-methyl) tetrahydropyranyl)
To a 50 ml glass flask equipped with a stirrer, thermometer, reflux condenser and dropping funnel, 4.58 g of paraaldehyde (104.1 mmol in terms of acetaldehyde) and 39.1 g (303 mmol) of dichloroacetic acid were added, and the liquid temperature reached 83 ° C. Heated until. Next, 6.25 g (86.7 mmol) of 3-buten-1-ol was gently added dropwise with stirring, and the mixture was reacted at the same temperature for 2 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure, and 100 ml of toluene and 100 ml of 5% by mass aqueous sodium hydrogen carbonate solution were added to the concentrate for separation. The aqueous layer was extracted twice with 30 ml of toluene, and the organic layer and the extract were combined and concentrated under reduced pressure to give dichloroacetic acid-4- (100% purity (area percentage by liquid chromatography) as a light brown oil. 15.7 g of 2-methyl) tetrahydropyranyl was obtained (isolation yield: 79.8%).
The physical properties of dichloroacetic acid-4- (2-methyl) tetrahydropyranyl were novel compounds represented by the following physical properties.

CI-MS (m / e); 227 (M + 1)
¹ H-NMR (CDCl ₃ , δ (ppm)); 1.24 (3H, d, J = 6.1 Hz), 1.41 (2H, m), 1.70 (2H, m), 3.44 to 3.55 (2H, m), 4.02 ~ 4.08 (1H, m), 4.94 ~ 5.04 (1H, m), 5.92 (1H, s)

Example 3 (Synthesis of chloroacetic acid-4-tetrahydropyranyl)
To a 50 ml glass flask equipped with a stirrer, a thermometer, a reflux condenser and a dropping funnel, 2.66 g of 95% by mass paraformaldehyde (84 mmol in terms of formaldehyde) and 23.2 g (245 mmol) of chloroacetic acid were added, and the liquid temperature was 83 Heated to ° C. Next, 5.05 g (70.0 mmol) of 3-buten-1-ol was gently added dropwise with stirring, and the mixture was reacted at the same temperature for 7 hours. After completion of the reaction, 300 ml of ethyl acetate and 412 ml of 5 mass% aqueous sodium hydrogen carbonate solution were added to the reaction solution to separate the layers. The aqueous layer was extracted twice with 30 ml of toluene, and then the organic layer and the extract were combined and concentrated under reduced pressure. The concentrate was purified by silica gel column chromatography (developing solvent; hexane / ethyl acetate = 3/1) and, as a colorless liquid, chloroacetic acid-4-tetrahydropyranyl 7.39 g with a purity of 98% (area percentage by differential refractive index) (Isolation yield: 57.7%).
The physical properties of chloroacetic acid-4-tetrahydropyranyl were novel compounds represented by the following physical properties.

CI-MS (m / e); 179 (M + 1), 85
¹ H-NMR (CDCl ₃ , δ (ppm)); 1.67 to 1.78 (2H, m), 1.91 to 2.00 (2H, m), 3.51 to 3.59 (2H, m), 3.89 to 3.96 (2H, m), 4.07 (2H, s), 5.00 ~ 5.09 (1H, m)

Example 4 (Synthesis of cyanoacetic acid-4-tetrahydropyranyl)
In a 100 ml glass flask equipped with a stirrer, thermometer, reflux condenser and dropping funnel, paraformaldehyde 3.29 g (104.1 mmol in terms of formaldehyde), cyanoacetic acid 25.8 g (260.1 mmol) and 1,2-dimethoxyethane 31.3 ml was added and heated until the liquid temperature reached 83 ° C. Next, 6.25 g (86.7 mmol) of 3-buten-1-ol was gently added dropwise with stirring, and the mixture was reacted at the same temperature for 2 hours. After completion of the reaction, 1000 ml of ethyl acetate and 510 ml of 5 mass% aqueous sodium hydrogen carbonate solution were added to the reaction solution to separate the layers. The aqueous layer was extracted twice with 200 ml of ethyl acetate, and then the organic layer and the extract were combined and concentrated under reduced pressure. The concentrate was purified by silica gel column chromatography (developing solvent; hexane / ethyl acetate = 3/1) to give 100% purity (area percentage by liquid chromatography) cyanoacetic acid-4-tetrahydropyranyl 0.63 as a brown oily substance. g was obtained (isolation yield: 4.6%).
The physical properties of cyanoacetic acid-4-tetrahydropyranyl were as follows.

CI-MS (m / e); 170 (M + 1), 85
¹ H-NMR (CDCl ₃ , δ (ppm)); 1.69 to 1.80 (2H, m), 1.92 to 2.00 (2H, m), 3.47 (2H, s), 3.48 to 3.63 (2H, m), 3.90 to 3.97 (2H, m), 5.03 ~ 5.08 (1H, m)

  The present invention relates to a method for producing a carboxylic acid-4-tetrahydropyranyl ester compound. The carboxylic acid-4-tetrahydropyranyl ester compound is a useful compound as a raw material for pharmaceuticals and agricultural chemicals, and a synthetic intermediate.

Claims (2)

3-Buten-1-ol, general formula (1)

(In the formula, R represents a hydrogen atom or a hydrocarbon group.)
And an aldehyde compound represented by the general formula (2a) or (2b)

(In the formula, X ¹ , X ² , X ³ , X ⁴ , X ⁵ , X ⁶ , X ⁷ and X ⁸ represent groups not involved in the reaction. In addition, X ¹ , X ² , X ³ , X ⁴ , X ⁵ , X ⁶ , X ⁷ and X ⁸ may be bonded to each other to form a ring.)
Or a carboxylic acid compound represented by the general formula (3a) or (3b)

(In the formula, X ¹ , X ² , X ³ , X ⁴ , X ⁵ , X ⁶ , X ⁷ , X ⁸ and R are as defined above.)
A process for producing a carboxylic acid-4-tetrahydropyranyl ester compound represented by the formula: General formula (4)

(In the formula, R is as defined above, and n represents an integer of 1 to 3.)
A carboxylic acid-4-tetrahydropyranyl ester compound represented by the formula: