JP2006001917A - Method for producing coenzyme q10 - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for producing coenzyme Q10 that has markedly improved properties by modifying the poor properties of this coenzyme, for example, markedly poor internal absorption, when it is taken as a medicine or ingested as a food because of its insolubility in water, easy degradability because of its over-sensitivity to light and high instability because of its easy oxidizability. <P>SOLUTION: Water is added to cyclodextrin, they are thoroughly mixed and coenzyme Q10 is homogeneously admixed to the slurry kneaded mixture of cyclodextrin. The mixture is further kneaded for a certain time, ordinarily 30 minutes to several hours whereby the coenzyme Q10 molecules are each included into the cavity of cyclodextrin molecule. Thus, the water solubility or water emulsification or suspension properties of coenzyme Q10 are improved and the hypersensitivity to light, the instability to oxidation and the like are also improved and stabilized. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a method for producing coenzyme Q10, a coenzyme having a high water solubility and emulsification ability.

Conventionally, coenzyme Q10, which is insoluble in water, etc., is directly tableted, encapsulated, and commercialized, so it is poorly absorbed in the gastrointestinal tract, has gastrointestinal disorders, has a reduced medicinal effect, and is easily damaged by light and oxidized. It has a stable nature.
In order to eliminate this defect, it was dissolved in oil etc. and processed into a soft capsule, etc., and the gastrointestinal absorption was considerably improved, the quality was stabilized, but the absorption was still insufficient and unstable to light. In addition, since it is a component that easily oxidizes, it has been used in an unfinished quality.

The conventional method has the following problems.
Coenzyme Q10 was tableted without being processed without being processed, or at most it was dissolved in oils to form a soft capsule.
However, this level of processing improved the gastrointestinal absorption somewhat and the coenzyme component, which was weak against light and easily oxidised instability, was still incomplete, but still incomplete.

Add usually 0.3 to 3 times the weight of cyclodextrin water, and mix Coenzyme Q10 uniformly into the well-mixed hydrate and mix well for a certain time (usually about 30 minutes to several hours) Coenzyme Q10 molecules are included in the cyclodextrin molecular cavity.
For example, when 50 ml of water is added to 100 g of cyclodextrin, 30 g of coenzyme Q10 is gradually added to the hydrated mixture mixed well in a muddy state, and stirred and mixed, the coenzyme Q10 molecule is included in the cyclodextrin molecular cavity. It can be modified to easily emulsify with water, and can be processed to be stable to light and oxidation.

  Conventional coenzyme Q10 is insoluble and hydrophobic in water, etc., and is easily decomposed when irradiated with light and easily oxidized, but has an unstable property. It is an oligomer in which 6 to 10 D-glucopyranose groups are cyclically linked by α (1.4) glucoside bond, and α- (6), β- (7), δ- (8) cyclodextrin is formed depending on the degree of polymerization. Mainly used, this cyclodextrin is mixed with water, and coenzyme Q10 is mixed with this hydrated (mixed with water) mixture. As a unimolecular host molecule having a cavity that can include a guest molecule), the guest molecule Coenzyme Q10 molecule is included and stabilized during this mixing time.

The production method will be described with an example.
Cyclodextrins include α-CD, β-CD, and δ-CD, and δ-CD is suitable for processing coenzyme Q10 molecules.
Add 50 ml of water to 100 g of cyclodextrin, knead well in a mortar, etc. to make a mud hydrate, gradually add 30 g of coenzyme Q10 powder, mix well, and crush for about 30 minutes to several hours. Thoroughly mix and stir with a machine, kneader, homogenizer, etc. to complete the inclusion process.
In general, it is considered that a hydrous clathrate has been produced when the viscosity slightly increases with time and becomes a paste. If necessary, the clathrate can be obtained by drying and washing with an appropriate solvent.

Claims (1)

  Coenzyme Q10 is mixed in a hydration mixture obtained by adding water to cyclodextrin and mixed, and is stirred and mixed for a certain period of time, usually about 30 minutes to several hours, and the coenzyme Q10 molecule is included in the cyclodextrin molecular cavity. Q10 manufacturing method.