JP2005538380A5 - - Google Patents
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- Publication number
- JP2005538380A5 JP2005538380A5 JP2004536454A JP2004536454A JP2005538380A5 JP 2005538380 A5 JP2005538380 A5 JP 2005538380A5 JP 2004536454 A JP2004536454 A JP 2004536454A JP 2004536454 A JP2004536454 A JP 2004536454A JP 2005538380 A5 JP2005538380 A5 JP 2005538380A5
- Authority
- JP
- Japan
- Prior art keywords
- specimen
- antibody
- specifically
- sbdp145
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100031874 Spectrin alpha chain, non-erythrocytic 1 Human genes 0.000 claims 21
- 101710157175 Spectrin alpha chain, non-erythrocytic 1 Proteins 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 19
- 239000012472 biological sample Substances 0.000 claims 14
- 239000003550 marker Substances 0.000 claims 10
- 239000007857 degradation product Substances 0.000 claims 6
- 210000002569 neuron Anatomy 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 5
- 230000005779 cell damage Effects 0.000 claims 4
- 208000037887 cell injury Diseases 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 230000006337 proteolytic cleavage Effects 0.000 claims 4
- 102000007590 Calpain Human genes 0.000 claims 3
- 108010032088 Calpain Proteins 0.000 claims 3
- 102000003952 Caspase 3 Human genes 0.000 claims 3
- 108090000397 Caspase 3 Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000000653 nervous system Anatomy 0.000 claims 3
- 230000003961 neuronal insult Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000005890 Spectrin Human genes 0.000 claims 1
- 108010019965 Spectrin Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40992002P | 2002-09-11 | 2002-09-11 | |
| PCT/US2003/028406 WO2004025298A1 (en) | 2002-09-11 | 2003-09-11 | Analyzing nerve cell damage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538380A JP2005538380A (ja) | 2005-12-15 |
| JP2005538380A5 true JP2005538380A5 (enExample) | 2007-12-13 |
Family
ID=31994033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004536454A Pending JP2005538380A (ja) | 2002-09-11 | 2003-09-11 | 神経細胞損傷の分析 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7291710B2 (enExample) |
| EP (3) | EP2211176A3 (enExample) |
| JP (1) | JP2005538380A (enExample) |
| AU (1) | AU2003270509B2 (enExample) |
| CA (1) | CA2498614C (enExample) |
| WO (1) | WO2004025298A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7396654B2 (en) * | 2004-04-15 | 2008-07-08 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for traumatic brain injury |
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| JP4885122B2 (ja) * | 2004-04-15 | 2012-02-29 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 癌、器官傷害、および筋肉リハビリテーション／運動過剰訓練についての診断の生物マーカーとしてのタンパク質分解マーカー |
| US8048638B2 (en) * | 2005-04-01 | 2011-11-01 | University Of Florida Research Foundation, Inc. | Biomarkers of liver injury |
| WO2006107846A2 (en) * | 2005-04-01 | 2006-10-12 | University Of Florida Research Foundation, Inc. | Biomakers of liver injury |
| EP1840574A1 (en) * | 2006-03-30 | 2007-10-03 | Institut Pasteur | Use of the alpha chain of brain spectrin and fragments thereof, for diagnosing cerebral diseases |
| EP2245466A2 (en) | 2008-02-04 | 2010-11-03 | Banyan Biomarkers, Inc. | Process to diagnose or treat brain injury |
| US20140342381A1 (en) * | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| JP5781436B2 (ja) | 2008-08-11 | 2015-09-24 | バンヤン・バイオマーカーズ・インコーポレーテッド | 神経学的状態のバイオマーカー検出方法およびアッセイ |
| AU2010262952B2 (en) | 2009-06-19 | 2016-01-07 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| WO2011032155A2 (en) | 2009-09-14 | 2011-03-17 | Banyan Biomarkers, Inc. | Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury |
| US9682132B2 (en) | 2010-01-26 | 2017-06-20 | Banyan Biomarkers, Inc | Compositions and methods relating to argininosucccinate synthetase |
| AU2011235892B2 (en) * | 2010-04-01 | 2016-07-07 | Banyan Biomarkers, Inc. | Markers and assays for detection of neurotoxicity |
| US11761959B2 (en) | 2013-03-15 | 2023-09-19 | The Trustees Of The University Of Pennsylvania | Blood biomarker that predicts persistent cognitive dysfunction after concussion |
| WO2015066211A1 (en) * | 2013-10-29 | 2015-05-07 | Banyan Biomarkers, Inc. | Uch-l1 isoforms, assays and devices for detection of a neurological condition |
| CN110366558A (zh) | 2016-10-28 | 2019-10-22 | 班扬生物标记公司 | 针对泛素c末端水解酶l1(uch-l1)和胶质纤维酸性蛋白(gfap)的抗体及相关方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118606A (en) * | 1988-09-02 | 1992-06-02 | The Regents Of The University Of California | Methods for detecting cellular pathology by assaying spectrin and spectrin breakdown products |
| US5116606A (en) * | 1989-03-09 | 1992-05-26 | Alt John P | Skin treatment method and solution |
| EP1695978A1 (en) | 1990-06-11 | 2006-08-30 | Gilead Sciences, Inc. | Nucleic acid ligands |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5536639A (en) | 1994-03-25 | 1996-07-16 | Cephalon, Inc. | Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products |
-
2003
- 2003-09-11 EP EP09014717A patent/EP2211176A3/en not_active Ceased
- 2003-09-11 AU AU2003270509A patent/AU2003270509B2/en not_active Ceased
- 2003-09-11 CA CA2498614A patent/CA2498614C/en not_active Expired - Lifetime
- 2003-09-11 EP EP10185059.2A patent/EP2348317B1/en not_active Expired - Lifetime
- 2003-09-11 WO PCT/US2003/028406 patent/WO2004025298A1/en not_active Ceased
- 2003-09-11 EP EP03752207A patent/EP1546717A4/en not_active Ceased
- 2003-09-11 JP JP2004536454A patent/JP2005538380A/ja active Pending
- 2003-09-11 US US10/660,069 patent/US7291710B2/en not_active Expired - Lifetime
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