JP2005537054A5 - - Google Patents
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- JP2005537054A5 JP2005537054A5 JP2004531512A JP2004531512A JP2005537054A5 JP 2005537054 A5 JP2005537054 A5 JP 2005537054A5 JP 2004531512 A JP2004531512 A JP 2004531512A JP 2004531512 A JP2004531512 A JP 2004531512A JP 2005537054 A5 JP2005537054 A5 JP 2005537054A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- substance
- microneedle
- microneedles
- improved pharmacokinetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000126 substance Substances 0.000 claims 9
- 238000010521 absorption reaction Methods 0.000 claims 3
- 210000004207 dermis Anatomy 0.000 claims 3
- 239000002955 immunomodulating agent Substances 0.000 claims 3
- 229940121354 immunomodulator Drugs 0.000 claims 3
- 230000002584 immunomodulator Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000002421 cell wall Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 229940047122 interleukins Drugs 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Claims (19)
- 免疫調節物質の送達による免疫系に関する一般的または特異的効果によって治療または予防をするのに使用するための医薬の製造のための免疫調節物質の使用であって、真皮中での前記物質の吸収を得るために前記真皮に前記物質を選択的に送達するのに適切な長さおよび出口を有する１本または複数の極微針を通して前記物質を皮内に注射または注入することを含むことを特徴とする、医薬の製造のための免疫調節物質の使用。
- 前記真皮中での前記物質の吸収が、皮下投与と比較して改善された全身的薬物動態を生じることを特徴とする請求項１に記載の使用。
- 前記改善された薬物動態が生物学的利用能の増加であることを特徴とする請求項２に記載の使用。
- 前記改善された薬物動態がＴｍａｘの減少であることを特徴とする請求項２に記載の使用。
- 前記改善された薬物動態がＣｍａｘの増加であることを特徴とする請求項２に記載の使用。
- 前記改善された薬物動態がＴｌａｇの減少であることを特徴とする請求項２に記載の使用。
- 前記改善された薬物動態が吸収速度の上昇であることを特徴とする請求項２に記載の使用。
- 前記極微針の長さが約０．５ｍｍから約１．７ｍｍまでであることを特徴とする請求項１に記載の使用。
- 前記極微針が３０ゲージ以下であることを特徴とする請求項１に記載の使用。
- 前記極微針が０ｍｍから１ｍｍまでの出口を有することを特徴とする請求項１に記載の使用。
- 前記極微針が、前記極微針を皮膚表面に対して垂直に配置する送達デバイス中に配置されることを特徴とする請求項１に記載の使用。
- 前記極微針の針が極微針の針のアレイ中に含まれることを特徴とする請求項１に記載の使用。
- 前記アレイが３本の極微針を含むことを特徴とする請求項１２に記載の使用。
- 前記アレイが６本の極微針を含むことを特徴とする請求項１２に記載の使用。
- 前記物質が免疫賦活剤であることを特徴とする請求項１に記載の使用。
- 前記物質が免疫抑制剤であることを特徴とする請求項１に記載の使用。
- 前記物質が、インターフェロン、インターロイキン、抗炎症剤、腫瘍標的化合物、および細菌細胞壁成分またはその合成誘導体からなる群から選択されることを特徴とする請求項１に記載の使用。
- 前記物質がリポ多糖もしくはＢＣＧ、またはそれらの合成誘導体であることを特徴とする請求項１７に記載の使用。
- 前記物質がα−インターフェロンであることを特徴とする請求項１７に記載の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40691602P | 2002-08-30 | 2002-08-30 | |
| PCT/US2003/026750 WO2004020014A2 (en) | 2002-08-30 | 2003-08-28 | Method of controlling pharmacokinetics of immunomodulatory compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005537054A JP2005537054A (ja) | 2005-12-08 |
| JP2005537054A5 true JP2005537054A5 (ja) | 2006-10-12 |
Family
ID=31978384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004531512A Withdrawn JP2005537054A (ja) | 2002-08-30 | 2003-08-28 | 免疫調節化合物の薬物動態を制御する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20040082934A1 (ja) |
| EP (1) | EP1539241A2 (ja) |
| JP (1) | JP2005537054A (ja) |
| AU (1) | AU2003262888A1 (ja) |
| BR (1) | BR0313890A (ja) |
| CA (1) | CA2497086A1 (ja) |
| MX (1) | MXPA05002270A (ja) |
| WO (1) | WO2004020014A2 (ja) |
| ZA (1) | ZA200501829B (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
| US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
| US20020156453A1 (en) * | 1999-10-14 | 2002-10-24 | Pettis Ronald J. | Method and device for reducing therapeutic dosage |
| US20040175360A1 (en) * | 2000-06-29 | 2004-09-09 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
| MXPA03009371A (es) * | 2001-04-13 | 2004-11-12 | Becton Dickinson Co | Metodos y dispositivos para administrar sustancias en la capa intradermica de la piel para absorcion sistemica. |
| EP1416986A4 (en) * | 2001-06-29 | 2005-12-14 | Becton Dickinson Co | INTRADERMIC DISTRIBUTION OF VACCINES AND GENE THERAPEUTIC AGENTS VIA MICROCANNULE |
| US20060018877A1 (en) * | 2001-06-29 | 2006-01-26 | Mikszta John A | Intradermal delivery of vacccines and therapeutic agents |
| CN1859943B (zh) * | 2002-10-11 | 2010-09-29 | 贝克顿·迪金森公司 | 用于控制患者体内葡萄糖的浓度的系统 |
| US20050256499A1 (en) * | 2004-03-03 | 2005-11-17 | Pettis Ronald J | Methods and devices for improving delivery of a substance to skin |
| US8554317B2 (en) * | 2005-11-30 | 2013-10-08 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| DK2791160T3 (da) | 2011-12-16 | 2022-05-30 | Modernatx Inc | Modificerede mrna-sammensætninger |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| WO2014113089A2 (en) | 2013-01-17 | 2014-07-24 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
Family Cites Families (48)
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|---|---|---|---|---|
| US3688764A (en) * | 1970-08-20 | 1972-09-05 | Bard Hamilton Co Inc | Intracutaneous injection system |
| US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| BE795384A (fr) * | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| US4270537A (en) * | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| IE53703B1 (en) * | 1982-12-13 | 1989-01-18 | Elan Corp Plc | Drug delivery device |
| CA1283827C (en) * | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
| US6056716A (en) * | 1987-06-08 | 2000-05-02 | D'antonio Consultants International Inc. | Hypodermic fluid dispenser |
| AU614092B2 (en) * | 1987-09-11 | 1991-08-22 | Paul Max Grinwald | Improved method and apparatus for enhanced drug permeation of skin |
| EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5098389A (en) * | 1990-06-28 | 1992-03-24 | Becton, Dickinson And Company | Hypodermic needle assembly |
| US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| TW279133B (ja) * | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
| US5156591A (en) * | 1990-12-13 | 1992-10-20 | S. I. Scientific Innovations Ltd. | Skin electrode construction and transdermal drug delivery device utilizing same |
| US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| SE9102652D0 (sv) * | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5279552A (en) * | 1993-01-11 | 1994-01-18 | Anton Magnet | Intradermal injection device |
| CA2132277C (en) * | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
| US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
| US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
| US5582591A (en) * | 1994-09-02 | 1996-12-10 | Delab | Delivery of solid drug compositions |
| IE72524B1 (en) * | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| WO1996037155A1 (en) * | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
| US5801057A (en) * | 1996-03-22 | 1998-09-01 | Smart; Wilson H. | Microsampling device and method of construction |
| ATE232116T1 (de) * | 1996-06-10 | 2003-02-15 | Elan Corp Plc | Nadel zur subkutanen verabreichung von flüssigkeiten |
| US5871158A (en) * | 1997-01-27 | 1999-02-16 | The University Of Utah Research Foundation | Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces |
| US5928207A (en) * | 1997-06-30 | 1999-07-27 | The Regents Of The University Of California | Microneedle with isotropically etched tip, and method of fabricating such a device |
| US6007821A (en) * | 1997-10-16 | 1999-12-28 | Fordham University | Method and compositions for the treatment of autoimmune disease using heat shock proteins |
| IE970782A1 (en) * | 1997-10-22 | 1999-05-05 | Elan Corp | An improved automatic syringe |
| US6482176B1 (en) * | 1997-11-27 | 2002-11-19 | Disetronic Licensing Ag | Method and device for controlling the introduction depth of an injection needle |
| IT1298087B1 (it) * | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US5957895A (en) * | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
| US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
| US6319224B1 (en) * | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
| US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
| US20020156453A1 (en) * | 1999-10-14 | 2002-10-24 | Pettis Ronald J. | Method and device for reducing therapeutic dosage |
| US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
| US6565532B1 (en) * | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
| US6607513B1 (en) * | 2000-06-08 | 2003-08-19 | Becton, Dickinson And Company | Device for withdrawing or administering a substance and method of manufacturing a device |
| US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
| US20040175360A1 (en) * | 2000-06-29 | 2004-09-09 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
| US20030073609A1 (en) * | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
| US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US20050096331A1 (en) * | 2001-12-21 | 2005-05-05 | Das Saibal K. | Novel compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them |
| US20050096332A1 (en) * | 2003-10-30 | 2005-05-05 | Boehringer Ingelheim International Gmbh | Use of tyrosine kinase inhibitors for the treatment of inflammatory processes |
| US20050256499A1 (en) * | 2004-03-03 | 2005-11-17 | Pettis Ronald J | Methods and devices for improving delivery of a substance to skin |
-
2003
- 2003-08-28 CA CA002497086A patent/CA2497086A1/en not_active Abandoned
- 2003-08-28 JP JP2004531512A patent/JP2005537054A/ja not_active Withdrawn
- 2003-08-28 US US10/650,039 patent/US20040082934A1/en not_active Abandoned
- 2003-08-28 BR BR0313890-9A patent/BR0313890A/pt not_active IP Right Cessation
- 2003-08-28 EP EP03791811A patent/EP1539241A2/en not_active Withdrawn
- 2003-08-28 AU AU2003262888A patent/AU2003262888A1/en not_active Abandoned
- 2003-08-28 WO PCT/US2003/026750 patent/WO2004020014A2/en active Search and Examination
- 2003-08-28 MX MXPA05002270A patent/MXPA05002270A/es not_active Application Discontinuation
-
2005
- 2005-03-03 ZA ZA200501829A patent/ZA200501829B/xx unknown
-
2007
- 2007-02-09 US US11/704,574 patent/US20070134719A1/en not_active Abandoned
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