JP2005521655A - 鎮痛を必要とする患者の処置方法 - Google Patents
鎮痛を必要とする患者の処置方法 Download PDFInfo
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- JP2005521655A JP2005521655A JP2003561577A JP2003561577A JP2005521655A JP 2005521655 A JP2005521655 A JP 2005521655A JP 2003561577 A JP2003561577 A JP 2003561577A JP 2003561577 A JP2003561577 A JP 2003561577A JP 2005521655 A JP2005521655 A JP 2005521655A
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- surfactant
- pharmaceutical composition
- devazepide
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- monophasic pharmaceutical
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- 238000010254 subcutaneous injection Methods 0.000 claims description 3
- 239000007929 subcutaneous injection Substances 0.000 claims description 3
- 239000000454 talc Substances 0.000 claims description 3
- 229910052623 talc Inorganic materials 0.000 claims description 3
- 235000012222 talc Nutrition 0.000 claims description 3
- 235000010384 tocopherol Nutrition 0.000 claims description 3
- 229960001295 tocopherol Drugs 0.000 claims description 3
- 229930003799 tocopherol Natural products 0.000 claims description 3
- 239000011732 tocopherol Substances 0.000 claims description 3
- 229960004380 tramadol Drugs 0.000 claims description 3
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims description 3
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 3
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229940095672 calcium sulfate Drugs 0.000 claims description 2
- 230000000249 desinfective effect Effects 0.000 claims description 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 2
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 229960001031 glucose Drugs 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 6
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 125000003158 alcohol group Chemical group 0.000 claims 2
- 239000007903 gelatin capsule Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 229960003511 macrogol Drugs 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 2
- RSSHKMSIEMOBQX-KFIKYVJASA-N (4r,4as,7ar,12bs)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C.O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C RSSHKMSIEMOBQX-KFIKYVJASA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 238000002716 delivery method Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 abstract description 7
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- NFHRQQKPEBFUJK-HSZRJFAPSA-N devazepide Chemical compound O=C([C@@H](NC(=O)C=1NC2=CC=CC=C2C=1)N=1)N(C)C2=CC=CC=C2C=1C1=CC=CC=C1 NFHRQQKPEBFUJK-HSZRJFAPSA-N 0.000 description 41
- 239000005557 antagonist Substances 0.000 description 5
- 206010010774 Constipation Diseases 0.000 description 4
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000007963 capsule composition Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 239000003754 cholecystokinin receptor blocking agent Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- YYCRAERBSFHMPL-XFKAJCMBSA-N (4r,4as,7ar,12bs)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound O=C([C@@H]1O2)C=C[C@@]3(O)[C@]4([H])N(C)CC[C@]13C1=C2C(OC)=CC=C1C4 YYCRAERBSFHMPL-XFKAJCMBSA-N 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229960000800 cetrimonium bromide Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- XJWSAJYUBXQQDR-UHFFFAOYSA-M dodecyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)C XJWSAJYUBXQQDR-UHFFFAOYSA-M 0.000 description 1
- 230000001189 fecal softening effect Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 208000021722 neuropathic pain Diseases 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- ZQHYKVKNPWDQSL-KNXBSLHKSA-N phenazocine Chemical compound C([C@@]1(C)C2=CC(O)=CC=C2C[C@@H]2[C@@H]1C)CN2CCC1=CC=CC=C1 ZQHYKVKNPWDQSL-KNXBSLHKSA-N 0.000 description 1
- 229960000897 phenazocine Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Laser Surgery Devices (AREA)
- Plural Heterocyclic Compounds (AREA)
- Electrotherapy Devices (AREA)
- Confectionery (AREA)
- Radiation-Therapy Devices (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0201367.0A GB0201367D0 (en) | 2002-01-22 | 2002-01-22 | Composition |
| PCT/GB2003/000221 WO2003061632A1 (en) | 2002-01-22 | 2003-01-22 | Method of treatment of a patient requiring analgesia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005521655A true JP2005521655A (ja) | 2005-07-21 |
| JP2005521655A5 JP2005521655A5 (https=) | 2006-03-09 |
Family
ID=9929492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003561577A Withdrawn JP2005521655A (ja) | 2002-01-22 | 2003-01-22 | 鎮痛を必要とする患者の処置方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1467718B1 (https=) |
| JP (1) | JP2005521655A (https=) |
| AT (1) | ATE310509T1 (https=) |
| BR (1) | BR0307022A (https=) |
| CA (1) | CA2473884A1 (https=) |
| DE (1) | DE60302431T2 (https=) |
| ES (1) | ES2253662T3 (https=) |
| GB (1) | GB0201367D0 (https=) |
| IL (1) | IL162768A0 (https=) |
| MX (1) | MXPA04007030A (https=) |
| NO (1) | NO20042758L (https=) |
| PL (1) | PL371523A1 (https=) |
| WO (1) | WO2003061632A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010539184A (ja) * | 2007-09-12 | 2010-12-16 | エラン・ファルマ・インターナショナル・リミテッド | 投薬レジメン |
| JP2012140393A (ja) * | 2011-01-03 | 2012-07-26 | Harrogate Holdings Ltd Co | 放出促進されたアンタゴニストを含む乱用抵抗性経皮薬物送達パッチ |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0213198D0 (en) * | 2002-06-10 | 2002-07-17 | Ml Lab Plc | Method of treatment |
| GB0406280D0 (en) * | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Chemical compounds |
| BRPI0520554A2 (pt) | 2005-09-19 | 2009-06-13 | Arrow Therapeutics Ltd | uso de uma benzodiazepina ou um sal farmaceuticamente aceitável do mesmo, método para tratar ou prevenir uma infecção por hcv em um paciente, derivado de benzodiazepina ou um sal famaceuticamente aceitável do mesmo, e, composição farmacêutica |
| WO2008051889A1 (en) * | 2006-10-24 | 2008-05-02 | The Johns Hopkins University | Rapid release mini-tablets provide analgesia in laboratory animals |
| EP2611445B1 (en) * | 2010-09-03 | 2018-08-15 | Zoetis Belgium S.A. | High dose buprenorphine compositions and use as analgesic |
| US10729687B1 (en) | 2019-07-09 | 2020-08-04 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| US10653690B1 (en) | 2019-07-09 | 2020-05-19 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| RS63725B1 (sr) | 2020-05-18 | 2022-12-30 | Orexo Ab | Nova farmaceutska kompozicija za davanje leka |
| GB202117016D0 (en) | 2021-11-25 | 2022-01-12 | Orexo Ab | New pharmaceutical device |
| AR127780A1 (es) | 2021-11-25 | 2024-02-28 | Orexo Ab | Nueva composición farmacéutica que comprende adrenalina |
| US12090151B1 (en) | 2023-05-12 | 2024-09-17 | Michael Guarnieri | Injectable sustained release buprenorphine formulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1564039A (en) * | 1976-12-09 | 1980-04-02 | Berger F | Analgesic compositions comprising dextropropoxyphene and benzodiazepines |
| US5153191A (en) * | 1991-08-20 | 1992-10-06 | Warner-Lambert Company | Cholecystokinin antagonists useful for treating depression |
| GB9721746D0 (en) * | 1997-10-15 | 1997-12-10 | Panos Therapeutics Limited | Compositions |
-
2002
- 2002-01-22 GB GBGB0201367.0A patent/GB0201367D0/en not_active Ceased
-
2003
- 2003-01-22 EP EP03708305A patent/EP1467718B1/en not_active Expired - Lifetime
- 2003-01-22 MX MXPA04007030A patent/MXPA04007030A/es not_active Application Discontinuation
- 2003-01-22 ES ES03708305T patent/ES2253662T3/es not_active Expired - Lifetime
- 2003-01-22 BR BR0307022-0A patent/BR0307022A/pt not_active IP Right Cessation
- 2003-01-22 JP JP2003561577A patent/JP2005521655A/ja not_active Withdrawn
- 2003-01-22 IL IL16276803A patent/IL162768A0/xx unknown
- 2003-01-22 AT AT03708305T patent/ATE310509T1/de not_active IP Right Cessation
- 2003-01-22 PL PL03371523A patent/PL371523A1/xx not_active Application Discontinuation
- 2003-01-22 CA CA002473884A patent/CA2473884A1/en not_active Abandoned
- 2003-01-22 DE DE60302431T patent/DE60302431T2/de not_active Expired - Fee Related
- 2003-01-22 WO PCT/GB2003/000221 patent/WO2003061632A1/en not_active Ceased
-
2004
- 2004-06-30 NO NO20042758A patent/NO20042758L/no not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010539184A (ja) * | 2007-09-12 | 2010-12-16 | エラン・ファルマ・インターナショナル・リミテッド | 投薬レジメン |
| JP2012140393A (ja) * | 2011-01-03 | 2012-07-26 | Harrogate Holdings Ltd Co | 放出促進されたアンタゴニストを含む乱用抵抗性経皮薬物送達パッチ |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE310509T1 (de) | 2005-12-15 |
| WO2003061632A1 (en) | 2003-07-31 |
| GB0201367D0 (en) | 2002-03-13 |
| MXPA04007030A (es) | 2004-10-11 |
| CA2473884A1 (en) | 2003-07-31 |
| IL162768A0 (en) | 2005-11-20 |
| NO20042758L (no) | 2004-09-22 |
| EP1467718A1 (en) | 2004-10-20 |
| BR0307022A (pt) | 2004-11-03 |
| EP1467718B1 (en) | 2005-11-23 |
| DE60302431D1 (de) | 2005-12-29 |
| PL371523A1 (en) | 2005-06-27 |
| DE60302431T2 (de) | 2006-07-27 |
| ES2253662T3 (es) | 2006-06-01 |
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