JP2005510250A5 - - Google Patents
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- JP2005510250A5 JP2005510250A5 JP2003547941A JP2003547941A JP2005510250A5 JP 2005510250 A5 JP2005510250 A5 JP 2005510250A5 JP 2003547941 A JP2003547941 A JP 2003547941A JP 2003547941 A JP2003547941 A JP 2003547941A JP 2005510250 A5 JP2005510250 A5 JP 2005510250A5
- Authority
- JP
- Japan
- Prior art keywords
- neuronal
- expression
- cells
- present
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710183811 Glia-derived nexin Proteins 0.000 description 19
- 102100033299 Glia-derived nexin Human genes 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000001537 neural effect Effects 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 229940122055 Serine protease inhibitor Drugs 0.000 description 6
- 101710102218 Serine protease inhibitor Proteins 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000003001 serine protease inhibitor Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 230000007996 neuronal plasticity Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 108700008625 Reporter Genes Proteins 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 102000005936 beta-Galactosidase Human genes 0.000 description 2
- 108010005774 beta-Galactosidase Proteins 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000001671 embryonic stem cell Anatomy 0.000 description 2
- 239000005090 green fluorescent protein Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 206010027175 memory impairment Diseases 0.000 description 2
- 238000000520 microinjection Methods 0.000 description 2
- 239000012474 protein marker Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 108010051219 Cre recombinase Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102100037591 Neuroserpin Human genes 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102000008847 Serpin Human genes 0.000 description 1
- 108050000761 Serpin Proteins 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 108010080874 neuroserpin Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0128793.7A GB0128793D0 (en) | 2001-11-30 | 2001-11-30 | Screening method for compounds that modulate neuronal activity |
| PCT/EP2002/013519 WO2003046552A2 (en) | 2001-11-30 | 2002-11-29 | Screening method for compounds that modulate neuronal activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005510250A JP2005510250A (ja) | 2005-04-21 |
| JP2005510250A5 true JP2005510250A5 (enExample) | 2006-01-12 |
Family
ID=9926820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547941A Pending JP2005510250A (ja) | 2001-11-30 | 2002-11-29 | ニューロン活性を調節する化合物のスクリーニング方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050019261A1 (enExample) |
| EP (1) | EP1459063A2 (enExample) |
| JP (1) | JP2005510250A (enExample) |
| AU (1) | AU2002358569A1 (enExample) |
| GB (1) | GB0128793D0 (enExample) |
| WO (1) | WO2003046552A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658912B2 (en) * | 2003-06-20 | 2010-02-09 | University Of Massachusetts | Spatial evolution of neural activity |
| US9018440B2 (en) * | 2006-10-27 | 2015-04-28 | Stowers Institute For Medical Research | Fluorescent mouse model |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2079880A1 (en) * | 1990-04-24 | 1991-10-25 | William E. Van Nostrand | Purification, detection and methods of use of protease nexin-2 |
| US5470970A (en) * | 1991-02-28 | 1995-11-28 | Dana-Farber Cancer Institute, Inc. | Maspin, a serpin with tumor suppresing activity |
| US5777194A (en) * | 1995-04-26 | 1998-07-07 | Cephalon, Inc. | Gene-targeted mice with humanized Aβ sequence and Swedish FAD mutation |
| US6008020A (en) * | 1996-10-11 | 1999-12-28 | Human Genome Sciences | Brain-associated inhibitor of tissue-type plasminogen activator |
| ATE301715T1 (de) * | 1998-10-16 | 2005-08-15 | Fraunhofer Ges Forschung | Durch molekulares pathogenicid vermittelte krankheitsresistenz in pflanzen |
-
2001
- 2001-11-30 GB GBGB0128793.7A patent/GB0128793D0/en not_active Ceased
-
2002
- 2002-11-29 AU AU2002358569A patent/AU2002358569A1/en not_active Abandoned
- 2002-11-29 JP JP2003547941A patent/JP2005510250A/ja active Pending
- 2002-11-29 WO PCT/EP2002/013519 patent/WO2003046552A2/en not_active Ceased
- 2002-11-29 US US10/497,089 patent/US20050019261A1/en not_active Abandoned
- 2002-11-29 EP EP02792839A patent/EP1459063A2/en not_active Withdrawn
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