JP2005510230A - アルファ−アミノアジピン酸レダクターゼおよびホモクエン酸シンターゼの阻害剤を抗生物質と同定する方法 - Google Patents

アルファ−アミノアジピン酸レダクターゼおよびホモクエン酸シンターゼの阻害剤を抗生物質と同定する方法 Download PDF

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JP2005510230A
JP2005510230A JP2003547565A JP2003547565A JP2005510230A JP 2005510230 A JP2005510230 A JP 2005510230A JP 2003547565 A JP2003547565 A JP 2003547565A JP 2003547565 A JP2003547565 A JP 2003547565A JP 2005510230 A JP2005510230 A JP 2005510230A
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fungal
cell
test compound
candidate
antibiotic
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Japanese (ja)
Inventor
タンザー，マシュー
シュスター，ジェフリー
ハマー，リスベス
喜一 安達
デズワーン，トッド
ロー，スゼ−チュン
モンテネグロ−チャモロ，マリア・ヴィクトリア
フランク，シェリル
ダーヴュークス，ブレイズ
マハンティ，サンジョイ
ハイニガー，ライアン
スカルチューンズ，アミー
パン，フアクイン
ターペイ，レックス
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パラダイム・ジェネティクス・インコーポレーテッド
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Priority claimed from US10/011,200 external-priority patent/US6632631B1/en
Priority claimed from US10/011,146 external-priority patent/US6723529B2/en
Application filed by パラダイム・ジェネティクス・インコーポレーテッド filed Critical パラダイム・ジェネティクス・インコーポレーテッド
Publication of JP2005510230A publication Critical patent/JP2005510230A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01031—L-Aminoadipate-semialdehyde dehydrogenase (1.2.1.31), i.e. alpha-aminoadipate reductase

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2003547565A 2001-11-09 2002-11-12 アルファ−アミノアジピン酸レダクターゼおよびホモクエン酸シンターゼの阻害剤を抗生物質と同定する方法 Pending JP2005510230A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/011,200 US6632631B1 (en) 2001-11-09 2001-11-09 Methods for the identification of inhibitors of homocitrate synthase as antibiotics
US10/011,146 US6723529B2 (en) 2001-11-09 2001-11-09 Methods for the identification of inhibitors of α-aminoadipate reductase as antibiotics
PCT/US2002/036508 WO2003046130A2 (fr) 2001-11-09 2002-11-12 Procedes d'identification d'inhibiteurs d'alpha-aminoadipate reductase et d'homocitrate synthase en tant qu'antibiotiques

Publications (1)

Publication Number Publication Date
JP2005510230A true JP2005510230A (ja) 2005-04-21

Family

ID=26682060

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003547565A Pending JP2005510230A (ja) 2001-11-09 2002-11-12 アルファ−アミノアジピン酸レダクターゼおよびホモクエン酸シンターゼの阻害剤を抗生物質と同定する方法

Country Status (5)

Country Link
EP (1) EP1481080A4 (fr)
JP (1) JP2005510230A (fr)
AU (1) AU2002365038A1 (fr)
CA (1) CA2469772A1 (fr)
WO (1) WO2003046130A2 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455248B1 (en) * 1996-05-20 2002-09-24 Miami University Reagents and kits for detecting fungal pathogens in a biological sample

Also Published As

Publication number Publication date
AU2002365038A1 (en) 2003-06-10
AU2002365038A8 (en) 2003-06-10
CA2469772A1 (fr) 2003-06-05
EP1481080A4 (fr) 2006-02-22
WO2003046130A3 (fr) 2004-09-16
EP1481080A2 (fr) 2004-12-01
WO2003046130A2 (fr) 2003-06-05

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