JP2005510230A - アルファ−アミノアジピン酸レダクターゼおよびホモクエン酸シンターゼの阻害剤を抗生物質と同定する方法 - Google Patents
アルファ−アミノアジピン酸レダクターゼおよびホモクエン酸シンターゼの阻害剤を抗生物質と同定する方法 Download PDFInfo
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- JP2005510230A JP2005510230A JP2003547565A JP2003547565A JP2005510230A JP 2005510230 A JP2005510230 A JP 2005510230A JP 2003547565 A JP2003547565 A JP 2003547565A JP 2003547565 A JP2003547565 A JP 2003547565A JP 2005510230 A JP2005510230 A JP 2005510230A
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- Prior art keywords
- fungal
- cell
- test compound
- candidate
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01031—L-Aminoadipate-semialdehyde dehydrogenase (1.2.1.31), i.e. alpha-aminoadipate reductase
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/011,200 US6632631B1 (en) | 2001-11-09 | 2001-11-09 | Methods for the identification of inhibitors of homocitrate synthase as antibiotics |
US10/011,146 US6723529B2 (en) | 2001-11-09 | 2001-11-09 | Methods for the identification of inhibitors of α-aminoadipate reductase as antibiotics |
PCT/US2002/036508 WO2003046130A2 (fr) | 2001-11-09 | 2002-11-12 | Procedes d'identification d'inhibiteurs d'alpha-aminoadipate reductase et d'homocitrate synthase en tant qu'antibiotiques |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2005510230A true JP2005510230A (ja) | 2005-04-21 |
Family
ID=26682060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003547565A Pending JP2005510230A (ja) | 2001-11-09 | 2002-11-12 | アルファ−アミノアジピン酸レダクターゼおよびホモクエン酸シンターゼの阻害剤を抗生物質と同定する方法 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1481080A4 (fr) |
JP (1) | JP2005510230A (fr) |
AU (1) | AU2002365038A1 (fr) |
CA (1) | CA2469772A1 (fr) |
WO (1) | WO2003046130A2 (fr) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6455248B1 (en) * | 1996-05-20 | 2002-09-24 | Miami University | Reagents and kits for detecting fungal pathogens in a biological sample |
-
2002
- 2002-11-12 AU AU2002365038A patent/AU2002365038A1/en not_active Abandoned
- 2002-11-12 WO PCT/US2002/036508 patent/WO2003046130A2/fr not_active Application Discontinuation
- 2002-11-12 CA CA002469772A patent/CA2469772A1/fr not_active Abandoned
- 2002-11-12 EP EP02803979A patent/EP1481080A4/fr not_active Withdrawn
- 2002-11-12 JP JP2003547565A patent/JP2005510230A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2002365038A1 (en) | 2003-06-10 |
AU2002365038A8 (en) | 2003-06-10 |
CA2469772A1 (fr) | 2003-06-05 |
EP1481080A4 (fr) | 2006-02-22 |
WO2003046130A3 (fr) | 2004-09-16 |
EP1481080A2 (fr) | 2004-12-01 |
WO2003046130A2 (fr) | 2003-06-05 |
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