AU2002365038A1 - Methods for the identification of inhibitors of alpha-aminoadipate reductase and homocitrate synthase as antibiotics - Google Patents

Methods for the identification of inhibitors of alpha-aminoadipate reductase and homocitrate synthase as antibiotics

Info

Publication number
AU2002365038A1
AU2002365038A1 AU2002365038A AU2002365038A AU2002365038A1 AU 2002365038 A1 AU2002365038 A1 AU 2002365038A1 AU 2002365038 A AU2002365038 A AU 2002365038A AU 2002365038 A AU2002365038 A AU 2002365038A AU 2002365038 A1 AU2002365038 A1 AU 2002365038A1
Authority
AU
Australia
Prior art keywords
antibiotics
inhibitors
alpha
identification
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002365038A
Other languages
English (en)
Other versions
AU2002365038A8 (en
Inventor
Kiichi Adachi
Blaise Darveaux
Todd Dezwaan
Sheryl Frank
Lisbeth Hamer
Ryan Heiniger
Sze-Chung Lo
Sanjoy Mahanty
Maria Victoria Montenegro-Chamorro
Huaquin Pan
Jeffrey Shuster
Amy Skalchunes
Matthew Tanzer
Rex Tarpey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Icoria Inc
Original Assignee
Paradigm Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/011,200 external-priority patent/US6632631B1/en
Priority claimed from US10/011,146 external-priority patent/US6723529B2/en
Application filed by Paradigm Genetics Inc filed Critical Paradigm Genetics Inc
Publication of AU2002365038A8 publication Critical patent/AU2002365038A8/xx
Publication of AU2002365038A1 publication Critical patent/AU2002365038A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01031—L-Aminoadipate-semialdehyde dehydrogenase (1.2.1.31), i.e. alpha-aminoadipate reductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2002365038A 2001-11-09 2002-11-12 Methods for the identification of inhibitors of alpha-aminoadipate reductase and homocitrate synthase as antibiotics Abandoned AU2002365038A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/011,200 US6632631B1 (en) 2001-11-09 2001-11-09 Methods for the identification of inhibitors of homocitrate synthase as antibiotics
US10/011,146 US6723529B2 (en) 2001-11-09 2001-11-09 Methods for the identification of inhibitors of α-aminoadipate reductase as antibiotics
US10/011,200 2001-11-09
US10/011,146 2001-11-09
PCT/US2002/036508 WO2003046130A2 (fr) 2001-11-09 2002-11-12 Procedes d'identification d'inhibiteurs d'alpha-aminoadipate reductase et d'homocitrate synthase en tant qu'antibiotiques

Publications (2)

Publication Number Publication Date
AU2002365038A8 AU2002365038A8 (en) 2003-06-10
AU2002365038A1 true AU2002365038A1 (en) 2003-06-10

Family

ID=26682060

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002365038A Abandoned AU2002365038A1 (en) 2001-11-09 2002-11-12 Methods for the identification of inhibitors of alpha-aminoadipate reductase and homocitrate synthase as antibiotics

Country Status (5)

Country Link
EP (1) EP1481080A4 (fr)
JP (1) JP2005510230A (fr)
AU (1) AU2002365038A1 (fr)
CA (1) CA2469772A1 (fr)
WO (1) WO2003046130A2 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455248B1 (en) * 1996-05-20 2002-09-24 Miami University Reagents and kits for detecting fungal pathogens in a biological sample

Also Published As

Publication number Publication date
AU2002365038A8 (en) 2003-06-10
EP1481080A2 (fr) 2004-12-01
WO2003046130A3 (fr) 2004-09-16
CA2469772A1 (fr) 2003-06-05
EP1481080A4 (fr) 2006-02-22
JP2005510230A (ja) 2005-04-21
WO2003046130A2 (fr) 2003-06-05

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase