JP2005507666A5 - - Google Patents

Info

Publication number

JP2005507666A5

JP2005507666A5 JP2003539604A JP2003539604A JP2005507666A5 JP 2005507666 A5 JP2005507666 A5 JP 2005507666A5 JP 2003539604 A JP2003539604 A JP 2003539604A JP 2003539604 A JP2003539604 A JP 2003539604A JP 2005507666 A5 JP2005507666 A5 JP 2005507666A5

Authority

JP

Japan

Prior art keywords

nucleic acid

pain

seq

polypeptide

composition

Prior art date

2002-10-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 102000039446 nucleic acids Human genes 0.000 claims 16
• 108020004707 nucleic acids Proteins 0.000 claims 16
• 150000007523 nucleic acids Chemical class 0.000 claims 16
• 108090000765 processed proteins & peptides Proteins 0.000 claims 15
• 150000001875 compounds Chemical class 0.000 claims 14
• 229920001184 polypeptide Polymers 0.000 claims 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims 12
• 239000000203 mixture Substances 0.000 claims 11
• 125000003275 alpha amino acid group Chemical group 0.000 claims 8
• 239000002773 nucleotide Substances 0.000 claims 8
• 125000003729 nucleotide group Chemical group 0.000 claims 8
• 208000027520 Somatoform disease Diseases 0.000 claims 6
• 208000027753 pain disease Diseases 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 5
• 230000000694 effects Effects 0.000 claims 5
• 230000008050 pain signaling Effects 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 230000000692 anti-sense effect Effects 0.000 claims 3
• 230000007246 mechanism Effects 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 208000002193 Pain Diseases 0.000 claims 2
• 230000002159 abnormal effect Effects 0.000 claims 2
• 206010058019 Cancer Pain Diseases 0.000 claims 1
• 208000000094 Chronic Pain Diseases 0.000 claims 1
• 208000001640 Fibromyalgia Diseases 0.000 claims 1
• 206010019233 Headaches Diseases 0.000 claims 1
• 206010065390 Inflammatory pain Diseases 0.000 claims 1
• 208000019695 Migraine disease Diseases 0.000 claims 1
• 208000001294 Nociceptive Pain Diseases 0.000 claims 1
• 210000004958 brain cell Anatomy 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 231100000869 headache Toxicity 0.000 claims 1
• 206010027599 migraine Diseases 0.000 claims 1
• 208000004296 neuralgia Diseases 0.000 claims 1
• 210000002569 neuron Anatomy 0.000 claims 1
• 208000021722 neuropathic pain Diseases 0.000 claims 1
• 210000000278 spinal cord Anatomy 0.000 claims 1
• 210000003594 spinal ganglia Anatomy 0.000 claims 1