JP2005506849A5 - - Google Patents
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- Publication number
- JP2005506849A5 JP2005506849A5 JP2003540336A JP2003540336A JP2005506849A5 JP 2005506849 A5 JP2005506849 A5 JP 2005506849A5 JP 2003540336 A JP2003540336 A JP 2003540336A JP 2003540336 A JP2003540336 A JP 2003540336A JP 2005506849 A5 JP2005506849 A5 JP 2005506849A5
- Authority
- JP
- Japan
- Prior art keywords
- hsc
- progeny
- fragment
- cell
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 53
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 52
- 229920002674 hyaluronan Polymers 0.000 claims 52
- 229960003160 hyaluronic acid Drugs 0.000 claims 52
- 101710128038 Hyaluronan synthase Proteins 0.000 claims 51
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 50
- 239000012634 fragment Substances 0.000 claims 37
- 238000000034 method Methods 0.000 claims 36
- 102000023732 binding proteins Human genes 0.000 claims 11
- 108091008324 binding proteins Proteins 0.000 claims 11
- 239000003550 marker Substances 0.000 claims 11
- 101000885616 Homo sapiens Galactoside alpha-(1,2)-fucosyltransferase 1 Proteins 0.000 claims 7
- 210000003995 blood forming stem cell Anatomy 0.000 claims 7
- 238000001514 detection method Methods 0.000 claims 6
- 238000002156 mixing Methods 0.000 claims 6
- 102000018866 Hyaluronan Receptors Human genes 0.000 claims 5
- 108010013214 Hyaluronan Receptors Proteins 0.000 claims 5
- 230000004069 differentiation Effects 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 101100260565 Dictyostelium discoideum thyA gene Proteins 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 150000001720 carbohydrates Chemical group 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 230000011748 cell maturation Effects 0.000 claims 1
- 229940047120 colony stimulating factors Drugs 0.000 claims 1
- 238000007398 colorimetric assay Methods 0.000 claims 1
- 238000003271 compound fluorescence assay Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 125000000600 disaccharide group Chemical group 0.000 claims 1
- 238000001952 enzyme assay Methods 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000009395 genetic defect Effects 0.000 claims 1
- 208000016361 genetic disease Diseases 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 229940097043 glucuronic acid Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000008569 process Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 230000008439 repair process Effects 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 101150068774 thyX gene Proteins 0.000 claims 1
- 230000004222 uncontrolled growth Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR8565A AUPR856501A0 (en) | 2001-10-30 | 2001-10-30 | Detection of haematopoietic stem cells and progeny and uses thereof |
| PCT/AU2002/001443 WO2003038071A1 (en) | 2001-10-30 | 2002-10-24 | Detection of haematopoietic stem cells and progeny and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009136863A Division JP2009232853A (ja) | 2001-10-30 | 2009-06-08 | 造血幹細胞およびその子孫の検出およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005506849A JP2005506849A (ja) | 2005-03-10 |
| JP2005506849A5 true JP2005506849A5 (OSRAM) | 2005-12-22 |
| JP4354275B2 JP4354275B2 (ja) | 2009-10-28 |
Family
ID=3832387
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003540336A Expired - Fee Related JP4354275B2 (ja) | 2001-10-30 | 2002-10-24 | 造血幹細胞およびその子孫の検出およびその使用 |
| JP2009136863A Pending JP2009232853A (ja) | 2001-10-30 | 2009-06-08 | 造血幹細胞およびその子孫の検出およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009136863A Pending JP2009232853A (ja) | 2001-10-30 | 2009-06-08 | 造血幹細胞およびその子孫の検出およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20050003460A1 (OSRAM) |
| EP (1) | EP1451303A4 (OSRAM) |
| JP (2) | JP4354275B2 (OSRAM) |
| AU (2) | AUPR856501A0 (OSRAM) |
| CA (1) | CA2464956A1 (OSRAM) |
| IL (2) | IL161690A0 (OSRAM) |
| WO (1) | WO2003038071A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030228635A1 (en) * | 2002-02-15 | 2003-12-11 | Renovar, Inc. | Cell proliferation assays and methods |
| US20100145032A1 (en) * | 2007-01-18 | 2010-06-10 | Suomen Punainen Risti, Veripalelu | Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof |
| WO2012048276A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| JP6057574B2 (ja) * | 2012-07-11 | 2017-01-11 | キヤノン株式会社 | 造血幹細胞識別用プローブ |
| CN105992816B (zh) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | 生物反应器中的细胞扩增 |
| CN106232800B (zh) | 2014-03-25 | 2020-07-03 | 泰尔茂比司特公司 | 介质的被动替代 |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US20170318781A1 (en) * | 2016-05-03 | 2017-11-09 | Cattle Time, Llc | Combined visual and rf identification (rfid) tag |
| CN109415696A (zh) | 2016-05-25 | 2019-03-01 | 泰尔茂比司特公司 | 细胞扩增 |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| EP3656841A1 (en) | 2017-03-31 | 2020-05-27 | Terumo BCT, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| EP4314244B1 (en) | 2021-03-23 | 2025-07-23 | Terumo BCT, Inc. | Cell capture and expansion |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6875753B1 (en) * | 1996-03-14 | 2005-04-05 | The Governors Of The University Of Alberta | Methods for cell mobilization using in vivo treatment with hyaluronan (HA) |
| AU3085699A (en) * | 1998-03-13 | 1999-09-27 | Entremed, Inc | Metastatin and hyaluronate binding proteins and methods of use |
| AU6056299A (en) * | 1998-09-21 | 2000-04-10 | Musc Foundation For Research Development | Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them |
| FR2789587B1 (fr) * | 1999-02-11 | 2003-01-24 | Inst Nat Sante Rech Med | Moyens pour la regulation de la differenciation hematopoietique |
| US20030032621A1 (en) * | 2000-02-11 | 2003-02-13 | Florence Smadja-Joffe | Means for regulating hematopoietic differentiation |
| WO2002044345A1 (en) * | 2000-12-01 | 2002-06-06 | The General Hospital Corporation | Methods and products for manipulating hematopoietic stem cells |
-
2001
- 2001-10-30 AU AUPR8565A patent/AUPR856501A0/en not_active Abandoned
-
2002
- 2002-10-24 EP EP02769779A patent/EP1451303A4/en not_active Withdrawn
- 2002-10-24 IL IL16169002A patent/IL161690A0/xx unknown
- 2002-10-24 WO PCT/AU2002/001443 patent/WO2003038071A1/en not_active Ceased
- 2002-10-24 JP JP2003540336A patent/JP4354275B2/ja not_active Expired - Fee Related
- 2002-10-24 CA CA002464956A patent/CA2464956A1/en not_active Abandoned
- 2002-10-24 AU AU2002335921A patent/AU2002335921B2/en not_active Ceased
-
2004
- 2004-04-30 US US10/837,038 patent/US20050003460A1/en not_active Abandoned
-
2007
- 2007-11-01 US US11/933,633 patent/US7718379B2/en not_active Expired - Fee Related
-
2009
- 2009-06-08 JP JP2009136863A patent/JP2009232853A/ja active Pending
-
2010
- 2010-03-19 US US12/727,697 patent/US20110020314A1/en not_active Abandoned
- 2010-04-28 IL IL205407A patent/IL205407A0/en unknown
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