JP2005502679A5 - - Google Patents
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- Publication number
- JP2005502679A5 JP2005502679A5 JP2003524594A JP2003524594A JP2005502679A5 JP 2005502679 A5 JP2005502679 A5 JP 2005502679A5 JP 2003524594 A JP2003524594 A JP 2003524594A JP 2003524594 A JP2003524594 A JP 2003524594A JP 2005502679 A5 JP2005502679 A5 JP 2005502679A5
- Authority
- JP
- Japan
- Prior art keywords
- hyperalgesia
- days
- mechanical
- measured
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31589801P | 2001-08-30 | 2001-08-30 | |
| PCT/EP2002/009662 WO2003020287A2 (en) | 2001-08-30 | 2002-08-29 | Methods for the treatment of chronic pain anc compositions therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005502679A JP2005502679A (ja) | 2005-01-27 |
| JP2005502679A5 true JP2005502679A5 (https=) | 2006-01-05 |
Family
ID=23226545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524594A Pending JP2005502679A (ja) | 2001-08-30 | 2002-08-29 | 慢性疼痛の処置方法およびそのための組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20030144234A1 (https=) |
| EP (1) | EP1423128A2 (https=) |
| JP (1) | JP2005502679A (https=) |
| WO (1) | WO2003020287A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03005601A (es) * | 2000-12-22 | 2004-12-02 | Axys Pharm Inc | Nuevos compuestos y composiciones como inhibidores de catepsina. |
| US20040147503A1 (en) * | 2002-06-04 | 2004-07-29 | Sheila Zipfeil | Novel compounds and compositions as cathepsin inhibitors |
| GB0220187D0 (en) | 2002-08-30 | 2002-10-09 | Novartis Ag | Organic compounds |
| PE20050068A1 (es) * | 2003-02-06 | 2005-03-11 | Novartis Ag | 2-cianopirrolopirimidinas como inhibidores de la catepsina s |
| US7384970B2 (en) | 2003-03-24 | 2008-06-10 | Irm Llc | Inhibitors of cathepsin S |
| US7109243B2 (en) | 2003-03-24 | 2006-09-19 | Irm Llc | Inhibitors of cathepsin S |
| EP1797883A3 (en) * | 2003-04-28 | 2007-08-01 | Novartis AG | Pharmaceutical composition comprising a cathepsin S inhibitor and an opioid |
| US20070037835A1 (en) * | 2003-04-28 | 2007-02-15 | Pamposh Ganju | Pharmaceutical composition comprising a cathepsin s inhibitor and an opioid |
| US7173051B2 (en) | 2003-06-13 | 2007-02-06 | Irm, Llc | Inhibitors of cathepsin S |
| WO2005014849A2 (en) * | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
| US7256207B2 (en) | 2003-08-20 | 2007-08-14 | Irm Llc | Inhibitors of cathepsin S |
| GB0324542D0 (en) * | 2003-10-21 | 2003-11-26 | Novartis Ag | Organic compounds |
| US7297714B2 (en) * | 2003-10-21 | 2007-11-20 | Irm Llc | Inhibitors of cathepsin S |
| TW200614993A (en) | 2004-06-11 | 2006-05-16 | Akzo Nobel Nv | 4-phenyl-pyrimidine-2-carbonitrile derivatives |
| US7309589B2 (en) | 2004-08-20 | 2007-12-18 | Vironix Llc | Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing |
| EP1879923B1 (en) | 2005-04-09 | 2015-05-27 | Fusion Antibodies Limited | Cathepsin s antibody |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| WO2006125105A2 (en) * | 2005-05-19 | 2006-11-23 | Wyeth | Methods and compositions for treating and diagnosing multiple sclerosis |
| JP2008545720A (ja) | 2005-06-02 | 2008-12-18 | メルク フロスト カナダ リミテツド | カテプシン阻害剤としてのフルオロアルキルアミン誘導体 |
| US7326715B2 (en) | 2005-09-23 | 2008-02-05 | N.V. Organon | 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives |
| US7687515B2 (en) | 2006-01-17 | 2010-03-30 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
| EP1991692A4 (en) * | 2006-02-21 | 2009-07-22 | Agency Science Tech & Res | METHOD AND REAGENTS FOR THE TREATMENT OF LIVER FIBROSIS AND INFLAMMATION |
| CA2648947A1 (en) * | 2006-04-10 | 2007-11-15 | Fusion Antibodies Limited | Therapy targeting cathepsin s |
| US20080269241A1 (en) * | 2007-02-15 | 2008-10-30 | Darin Allen | Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
| US20080207683A1 (en) * | 2007-02-15 | 2008-08-28 | Darin Allen | Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
| US20080200454A1 (en) * | 2007-02-15 | 2008-08-21 | Ameriks Michael K | Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
| US20090118274A1 (en) * | 2007-02-15 | 2009-05-07 | Darin Allen | Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
| US20090099157A1 (en) * | 2007-02-15 | 2009-04-16 | Ameriks Michael K | Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s |
| US7932251B2 (en) | 2007-07-16 | 2011-04-26 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
| EP2105742A1 (en) * | 2008-03-26 | 2009-09-30 | Sanofi-Aventis | Use of cathepsin C |
| BRPI0922283A2 (pt) | 2008-12-19 | 2015-12-29 | Medivir Uk Ltd | inibidores da cistéina protease |
| US8026236B2 (en) | 2009-01-16 | 2011-09-27 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
| EP2293072A1 (en) * | 2009-08-31 | 2011-03-09 | Sanofi-Aventis | Use of cathepsin H |
| EP2582660B1 (en) | 2010-06-16 | 2015-07-22 | Medivir UK Ltd | New cathepsin s protease inhibitors, useful in the treatment of e.g. autoimmune disorders, allergy and chronic pain conditions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518528A (en) * | 1983-05-19 | 1985-05-21 | Rasnick David W | α Amino fluoro ketones |
| US5795977A (en) * | 1989-09-15 | 1998-08-18 | Metabasis Therapeutics, Inc. | Water soluble adenosine kinase inhibitors |
| US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
| CA2251714A1 (en) * | 1996-04-22 | 1997-10-30 | Massachusetts Institute Of Technology | Suppression of immune response via inhibition of cathepsin s |
| EP1159273A1 (en) * | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| GB0121033D0 (en) * | 2001-08-30 | 2001-10-24 | Novartis Ag | Organic compounds |
-
2002
- 2002-08-28 US US10/231,425 patent/US20030144234A1/en not_active Abandoned
- 2002-08-29 JP JP2003524594A patent/JP2005502679A/ja active Pending
- 2002-08-29 EP EP02797651A patent/EP1423128A2/en not_active Ceased
- 2002-08-29 WO PCT/EP2002/009662 patent/WO2003020287A2/en not_active Ceased
-
2006
- 2006-12-22 US US11/644,658 patent/US20070129366A1/en not_active Abandoned
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