JP2005502679A5 - - Google Patents

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Publication number
JP2005502679A5
JP2005502679A5 JP2003524594A JP2003524594A JP2005502679A5 JP 2005502679 A5 JP2005502679 A5 JP 2005502679A5 JP 2003524594 A JP2003524594 A JP 2003524594A JP 2003524594 A JP2003524594 A JP 2003524594A JP 2005502679 A5 JP2005502679 A5 JP 2005502679A5
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JP
Japan
Prior art keywords
hyperalgesia
days
mechanical
measured
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003524594A
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English (en)
Japanese (ja)
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JP2005502679A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2002/009662 external-priority patent/WO2003020287A2/en
Publication of JP2005502679A publication Critical patent/JP2005502679A/ja
Publication of JP2005502679A5 publication Critical patent/JP2005502679A5/ja
Pending legal-status Critical Current

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JP2003524594A 2001-08-30 2002-08-29 慢性疼痛の処置方法およびそのための組成物 Pending JP2005502679A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31589801P 2001-08-30 2001-08-30
PCT/EP2002/009662 WO2003020287A2 (en) 2001-08-30 2002-08-29 Methods for the treatment of chronic pain anc compositions therefor

Publications (2)

Publication Number Publication Date
JP2005502679A JP2005502679A (ja) 2005-01-27
JP2005502679A5 true JP2005502679A5 (cg-RX-API-DMAC7.html) 2006-01-05

Family

ID=23226545

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003524594A Pending JP2005502679A (ja) 2001-08-30 2002-08-29 慢性疼痛の処置方法およびそのための組成物

Country Status (4)

Country Link
US (2) US20030144234A1 (cg-RX-API-DMAC7.html)
EP (1) EP1423128A2 (cg-RX-API-DMAC7.html)
JP (1) JP2005502679A (cg-RX-API-DMAC7.html)
WO (1) WO2003020287A2 (cg-RX-API-DMAC7.html)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1383748A2 (en) * 2000-12-22 2004-01-28 Axys Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors
US20040147503A1 (en) * 2002-06-04 2004-07-29 Sheila Zipfeil Novel compounds and compositions as cathepsin inhibitors
GB0220187D0 (en) 2002-08-30 2002-10-09 Novartis Ag Organic compounds
AR043692A1 (es) * 2003-02-06 2005-08-10 Novartis Ag 2-cianopirrolopirimidinas y sus usos farmaceuticos
US7384970B2 (en) 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7109243B2 (en) 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
CA2521741A1 (en) * 2003-04-28 2004-11-11 Novartis Ag Pharmaceutical composition comprising a cathepsin s inhibitor and an opioid
EP1797883A3 (en) * 2003-04-28 2007-08-01 Novartis AG Pharmaceutical composition comprising a cathepsin S inhibitor and an opioid
US7173051B2 (en) 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
WO2005014849A2 (en) * 2003-07-03 2005-02-17 Euro-Celtique, S.A. Genes associated with responses to neuropathic pain
US7256207B2 (en) 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
GB0324542D0 (en) * 2003-10-21 2003-11-26 Novartis Ag Organic compounds
US7297714B2 (en) * 2003-10-21 2007-11-20 Irm Llc Inhibitors of cathepsin S
TW200614993A (en) 2004-06-11 2006-05-16 Akzo Nobel Nv 4-phenyl-pyrimidine-2-carbonitrile derivatives
US7309589B2 (en) 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
EP1879923B1 (en) 2005-04-09 2015-05-27 Fusion Antibodies Limited Cathepsin s antibody
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
WO2006125105A2 (en) * 2005-05-19 2006-11-23 Wyeth Methods and compositions for treating and diagnosing multiple sclerosis
US20090099264A1 (en) 2005-06-02 2009-04-16 Merck Frosst Canada Ltd. Fluoroalkylamine Derivatives as Cathepsin Inhibtors
US7326715B2 (en) 2005-09-23 2008-02-05 N.V. Organon 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
US7687515B2 (en) 2006-01-17 2010-03-30 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
GB2449601B (en) * 2006-02-21 2010-06-23 Agency Science Tech & Res Method and reagents for treating hepatic fibrosis and inflammation
BRPI0710055A2 (pt) 2006-04-10 2011-08-02 Fusion Antibodies Ltd métodos de inibir regulação ascendente induzida por quimioterapia de catepsina s, expressão de catepsina s sobre a superfìcie de células de tumor e angiogênese em um grupo de células, um tecido ou um órgão, de tratar doença neoplásica e uma condição associada com atividade de catepsina s em um paciente, de induzir reação citotóxica mediada por célula dependente de anticorpo contra uma célula de tumor, de matar células de tumor, de identificar células de tumor em uma população de células e de avaliar in vitro a resposta de células de tumor de um indivìduo à presença de um agente quimioterápico, usos de um inibidor de catepsina s e um agente quimioterapêutico, de catepsina s, de um anticorpo anti-catepsina s ou um fragmento do mesmo e de uma molécula de anticorpo, composição farmacêutica, kit farmacêutico e molécula de anticorpo ou um ácido nucleico codificando dita molécula de anticorpo
US20090099157A1 (en) * 2007-02-15 2009-04-16 Ameriks Michael K Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s
US20080200454A1 (en) * 2007-02-15 2008-08-21 Ameriks Michael K Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080207683A1 (en) * 2007-02-15 2008-08-28 Darin Allen Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080269241A1 (en) * 2007-02-15 2008-10-30 Darin Allen Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090118274A1 (en) * 2007-02-15 2009-05-07 Darin Allen Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US7932251B2 (en) 2007-07-16 2011-04-26 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
EP2105742A1 (en) * 2008-03-26 2009-09-30 Sanofi-Aventis Use of cathepsin C
CN102264710B (zh) 2008-12-19 2014-11-05 美迪维尔英国有限公司 半胱氨酸蛋白酶抑制剂
US8026236B2 (en) 2009-01-16 2011-09-27 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
EP2293072A1 (en) * 2009-08-31 2011-03-09 Sanofi-Aventis Use of cathepsin H
PH12012502371A1 (en) 2010-06-16 2018-02-07 Medivir Uk Ltd New cathepsin protease inhibitors, useful in the treatment of e.g. autoimmune disorders, allergy and chronic pain conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
US5795977A (en) * 1989-09-15 1998-08-18 Metabasis Therapeutics, Inc. Water soluble adenosine kinase inhibitors
US5714484A (en) * 1993-12-08 1998-02-03 Prototek, Inc. α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
PT912601E (pt) * 1996-04-22 2004-04-30 Massachusetts Inst Technology Supressao da resposta imune via inibicao da catepsina s
US6395897B1 (en) * 1999-03-02 2002-05-28 Boehringer Ingelheim Pharmaceuticals, Inc. Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5
GB0121033D0 (en) * 2001-08-30 2001-10-24 Novartis Ag Organic compounds

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