JP2005501802A5 - - Google Patents
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- JP2005501802A5 JP2005501802A5 JP2002563950A JP2002563950A JP2005501802A5 JP 2005501802 A5 JP2005501802 A5 JP 2005501802A5 JP 2002563950 A JP2002563950 A JP 2002563950A JP 2002563950 A JP2002563950 A JP 2002563950A JP 2005501802 A5 JP2005501802 A5 JP 2005501802A5
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- JP
- Japan
- Prior art keywords
- composition
- promoter
- fgf
- cells
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 74
- 210000001519 tissue Anatomy 0.000 claims 21
- 239000002870 angiogenesis inducing agent Substances 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 14
- 229940124597 therapeutic agent Drugs 0.000 claims 13
- 230000000302 ischemic effect Effects 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 239000013603 viral vector Substances 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 7
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 7
- 210000004165 myocardium Anatomy 0.000 claims 7
- 108090000380 Fibroblast growth factor 5 Proteins 0.000 claims 6
- 102100028073 Fibroblast growth factor 5 Human genes 0.000 claims 6
- 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 claims 6
- 102100040990 Platelet-derived growth factor subunit B Human genes 0.000 claims 6
- 210000000130 stem cell Anatomy 0.000 claims 6
- 241000701161 unidentified adenovirus Species 0.000 claims 6
- 102000009840 Angiopoietins Human genes 0.000 claims 5
- 108010009906 Angiopoietins Proteins 0.000 claims 5
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 5
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 5
- 102100032449 EGF-like repeat and discoidin I-like domain-containing protein 3 Human genes 0.000 claims 5
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 5
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 5
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 5
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 5
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims 5
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 claims 5
- 101001016381 Homo sapiens EGF-like repeat and discoidin I-like domain-containing protein 3 Proteins 0.000 claims 5
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims 5
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 claims 5
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 5
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims 5
- 102100028452 Nitric oxide synthase, endothelial Human genes 0.000 claims 5
- 101710090055 Nitric oxide synthase, endothelial Proteins 0.000 claims 5
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 claims 5
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 claims 5
- 101710103506 Platelet-derived growth factor subunit A Proteins 0.000 claims 5
- 101710103494 Platelet-derived growth factor subunit B Proteins 0.000 claims 5
- 230000033115 angiogenesis Effects 0.000 claims 5
- 210000004413 cardiac myocyte Anatomy 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 4
- 102000058223 human VEGFA Human genes 0.000 claims 4
- 239000013600 plasmid vector Substances 0.000 claims 4
- 230000017423 tissue regeneration Effects 0.000 claims 4
- 230000008828 contractile function Effects 0.000 claims 3
- 239000003102 growth factor Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 230000002107 myocardial effect Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 241000252233 Cyprinus carpio Species 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 101150050438 NPPA gene Proteins 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 210000005087 mononuclear cell Anatomy 0.000 claims 2
- 230000001114 myogenic effect Effects 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 230000007998 vessel formation Effects 0.000 claims 2
- 206010008479 Chest Pain Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 108010041308 Endothelial Growth Factors Proteins 0.000 claims 1
- 101150021185 FGF gene Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101100519221 Homo sapiens PDGFB gene Proteins 0.000 claims 1
- 101000602164 Homo sapiens Platelet-derived growth factor subunit A Proteins 0.000 claims 1
- 102100020880 Kit ligand Human genes 0.000 claims 1
- 108010039445 Stem Cell Factor Proteins 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 230000005465 channeling Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000001976 improved effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000002464 muscle smooth vascular Anatomy 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 230000008477 smooth muscle tissue growth Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26346801P | 2001-01-23 | 2001-01-23 | |
| PCT/US2002/003118 WO2002064157A2 (en) | 2001-01-23 | 2002-01-23 | Localized myocardial injection method for treating ischemic myocardium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501802A JP2005501802A (ja) | 2005-01-20 |
| JP2005501802A5 true JP2005501802A5 (https=) | 2005-12-22 |
Family
ID=23001908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563950A Pending JP2005501802A (ja) | 2001-01-23 | 2002-01-23 | 虚血心筋を処置するための限局性心筋注入方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20020172663A1 (https=) |
| EP (1) | EP1361896A2 (https=) |
| JP (1) | JP2005501802A (https=) |
| CA (1) | CA2433936A1 (https=) |
| WO (1) | WO2002064157A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7288521B2 (en) | 2000-04-06 | 2007-10-30 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
| US20100303769A1 (en) * | 2000-04-06 | 2010-12-02 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
| US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
| US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| JP4653952B2 (ja) | 2001-12-07 | 2011-03-16 | サイトリ セラピューティクス インコーポレイテッド | 処理済み脂肪吸引細胞で患者を治療するためのシステムと方法 |
| US20050048035A1 (en) | 2001-12-07 | 2005-03-03 | Fraser John K. | Methods of using regenerative cells in the treatment of stroke and related diseases and disorders |
| US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| KR100562824B1 (ko) | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| US20040258669A1 (en) * | 2002-11-05 | 2004-12-23 | Dzau Victor J. | Mesenchymal stem cells and methods of use thereof |
| US7627373B2 (en) | 2002-11-30 | 2009-12-01 | Cardiac Pacemakers, Inc. | Method and apparatus for cell and electrical therapy of living tissue |
| US7781415B2 (en) | 2003-02-07 | 2010-08-24 | Roche Madison Inc. | Process for delivering sirna to cardiac muscle tissue |
| CA2516510C (en) * | 2003-02-20 | 2012-07-10 | Macropore Biosurgery, Inc. | Method of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US7840263B2 (en) | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
| US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
| US7729761B2 (en) * | 2004-07-14 | 2010-06-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlled gene or protein delivery |
| EP1827494A4 (en) * | 2004-11-18 | 2010-02-17 | Wayne Franco | COMBINATION GROWTH THERAPY AND CELL THERAPY FOR THE TREATMENT OF ACUTE AND CHRONIC ORGANIC DISEASES |
| US8060219B2 (en) | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
| US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
| US20100028312A1 (en) * | 2005-03-24 | 2010-02-04 | Caritas St. Elizabeth Medical Center of Boston Inc | Stably transformed bone marrow-derived cells and uses thereof |
| US7774057B2 (en) | 2005-09-06 | 2010-08-10 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression for cardiac protection |
| US20110076255A1 (en) | 2005-11-07 | 2011-03-31 | Pecora Andrew L | Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency |
| US8637005B2 (en) | 2005-11-07 | 2014-01-28 | Amorcyte, Inc. | Compositions and methods of vascular injury repair |
| MY147516A (en) * | 2005-11-07 | 2012-12-31 | Amorcyte Inc | Compositions and method of vascular injury repair cross-reference to related applications |
| US20070190028A1 (en) * | 2006-02-13 | 2007-08-16 | Jihong Qu | Method and apparatus for heat or electromagnetic control of gene expression |
| WO2009065080A1 (en) * | 2007-11-16 | 2009-05-22 | San Diego State University Research Foundation | Compositions and method for manipulating pim-1 activity in circulatory system cells |
| US20090202606A1 (en) * | 2008-01-25 | 2009-08-13 | Viromed Co., Ltd. | Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor |
| WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
| CN102245189B (zh) | 2008-12-03 | 2015-06-17 | 阿莫塞特公司 | 改善梗死区灌注的组合物以及血管损伤修复方法 |
| KR101738324B1 (ko) | 2009-05-01 | 2017-05-19 | 비미니 테크놀로지스 엘엘씨 | 조직 및 세포 부유화 이식편의 최적화 시스템, 방법 및 조성물 |
| WO2010138180A2 (en) * | 2009-05-26 | 2010-12-02 | The University Of Vermont And State Agriculture College | Compositions and methods for cardiac tissue repair |
| WO2013138338A2 (en) | 2012-03-12 | 2013-09-19 | Massachusetts Institute Of Technology | Methods for treating tissue damage associated with ischemia with apoliporotein d |
| CN105682676B (zh) | 2013-10-22 | 2020-10-23 | 赫利世弥斯株式会社 | 利用肝细胞生长因子的两种以上的异构体的肌萎缩性侧索硬化症预防或治疗用组合物 |
| RU2570285C1 (ru) * | 2014-11-25 | 2015-12-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ лечения субкритической ишемии конечности на фоне хронических облитерирующих заболеваний артерий нижних конечностей |
| CA2973096A1 (en) | 2015-01-06 | 2016-07-14 | Cardiovascular Biotherapeutics, Inc. | Angiogenic treatment of ischemic heart disease |
| AU2016220304B2 (en) | 2015-02-16 | 2019-07-25 | Venturis Therapeutics, Inc. | Therapeutic angiogenesis for treating erectile conditions |
| US10813612B2 (en) | 2019-01-25 | 2020-10-27 | Cleerly, Inc. | Systems and method of characterizing high risk plaques |
| US11501436B2 (en) | 2020-01-07 | 2022-11-15 | Cleerly, Inc. | Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking |
| US20220392065A1 (en) | 2020-01-07 | 2022-12-08 | Cleerly, Inc. | Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking |
| US11969280B2 (en) | 2020-01-07 | 2024-04-30 | Cleerly, Inc. | Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking |
| KR20220090951A (ko) * | 2020-12-23 | 2022-06-30 | 건국대학교 산학협력단 | 섬유아세포 성장인자의 신규 단편 및 이의 용도 |
| CN114053224A (zh) * | 2021-09-07 | 2022-02-18 | 山东第一医科大学附属省立医院(山东省立医院) | 含βARKct的脂质体复合物及其制备方法和应用 |
| US20250217981A1 (en) | 2022-03-10 | 2025-07-03 | Cleerly, Inc. | Systems, methods, and devices for image-based plaque analysis and risk determination |
| US12406365B2 (en) | 2022-03-10 | 2025-09-02 | Cleerly, Inc. | Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination |
| US20250143657A1 (en) | 2022-03-10 | 2025-05-08 | Cleerly, Inc. | Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination |
| US12440180B2 (en) | 2022-03-10 | 2025-10-14 | Cleerly, Inc. | Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5661133B1 (en) * | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
| US5221272A (en) * | 1991-12-03 | 1993-06-22 | Safegrip, Inc. | Unified medical fluid system |
| JPH08506008A (ja) * | 1992-11-18 | 1996-07-02 | アーチ ディベロプメント コーポレイション | 心筋及び血管平滑筋へのアデノウィルス介在遺伝子移入 |
| US5631237A (en) * | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
| GB9401447D0 (en) * | 1994-01-26 | 1994-03-23 | Ciba Geigy Ag | Pharmaceutical compositions |
| US7186688B1 (en) * | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
| US6152141A (en) * | 1994-07-28 | 2000-11-28 | Heartport, Inc. | Method for delivery of therapeutic agents to the heart |
| WO1996026742A1 (en) * | 1995-02-28 | 1996-09-06 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| US5800539A (en) * | 1995-11-08 | 1998-09-01 | Emory University | Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease |
| AU745409B2 (en) * | 1997-01-29 | 2002-03-21 | Cornell Research Foundation Inc. | Multiple site delivery of adenoviral vector for the induction of angiogenesis |
| US6045565A (en) * | 1997-11-04 | 2000-04-04 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization growth factor mediums and method |
| CA2296704C (en) * | 1997-07-14 | 2010-10-19 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US7078387B1 (en) * | 1998-12-28 | 2006-07-18 | Arch Development Corp. | Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors |
| WO2000057922A1 (en) * | 1999-03-30 | 2000-10-05 | Ran Kornowski | Intramyocardial injection of autologous bone marrow |
| US7097832B1 (en) * | 1999-03-30 | 2006-08-29 | Myocardial Therapeutics, Inc. | Intramyocardial injection of autologous bone marrow |
| AU2001284695A1 (en) * | 2000-07-31 | 2002-02-13 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
-
2002
- 2002-01-23 EP EP02720895A patent/EP1361896A2/en not_active Withdrawn
- 2002-01-23 US US10/057,409 patent/US20020172663A1/en not_active Abandoned
- 2002-01-23 WO PCT/US2002/003118 patent/WO2002064157A2/en not_active Ceased
- 2002-01-23 CA CA002433936A patent/CA2433936A1/en not_active Abandoned
- 2002-01-23 JP JP2002563950A patent/JP2005501802A/ja active Pending
-
2008
- 2008-05-16 US US12/122,561 patent/US20080254109A1/en not_active Abandoned
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