JP2005331420A - Nmr analyzer and test method therefor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To solve the problem, wherein all of information is concentrated in a console part, in inspection and maintenance work, and wherein a sample analytical part is difficult to be inspected and maintained, since the console part is arranged apart from the sample analytical part, along with the high resolution of an NMR analyzer, in the NMR analyzer. <P>SOLUTION: In this NMR analyzer, the information collected in the console part is transmitted to a mobile display terminal by communication, and a signal processing part of the sample analytical part is precluded from being affected due to the influence thereof, to conduct the inspection using the mobile display terminal. The NMR analyzer and a method therefor allow, even one person to execute the inspection and maintenance work, and are convenient in use. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an NMR analyzer and an inspection method thereof.

  An NMR analyzer used for protein structure analysis or the like is roughly divided into a sample installing unit, a sample analyzing unit including a strong magnetic field generating magnet and a probe, an RF signal transmitting / receiving system, and a console unit including a computer. One of the main performances of NMR analyzers is resolution, and the higher the resolution, the greater the generated magnetic field strength. As the generated magnetic field increases, the leakage magnetic field from the magnet also increases, and the 5 gauss region (region in which interference with a magnetic field to a device such as a cardiac pacemaker may occur) becomes wide. For this reason, the distance between the console unit that can be operated by a general person and the sample analysis unit is more distant from the NMR analyzer with higher resolution. In some cases, the distance is around 10 m, or a sample analysis room and a console room are provided separately.

  Since information necessary for NMR analysis is collected in the console unit, in normal analysis work, work other than setting the analysis sample is directed to the console. However, if a defect occurs in the probe peripheral circuit of the NMR analyzer, the magnet, or the sample installation unit, it is necessary to approach the sample analysis unit and implement measures such as adjustment and observe the results. Since most of the operation information of the NMR analyzer is collected in the console section, in order to know the operation information in the inspection and maintenance process such as adjustment and defect countermeasures, it has been necessary to return to the console once or work by multiple people. There is a problem in that it is necessary to carry out and is not easy to use in the inspection and maintenance of the NMR analyzer.

  Further, as important information necessary for the inspection and maintenance of the NMR analyzer, there is RF transmission power to be irradiated in order to cause nuclear magnetic resonance in the analysis sample. At present, there is a commercially available NMR analyzer that puts a head amplifier box near the sample analyzer and obtains RF transmission power by placing a power meter in the box, which is useful for inspection maintenance work near the sample analyzer. ing.

  Furthermore, in Japanese Patent Application Laid-Open No. 2003-28942 [Patent Document 1], a head amplifier box is placed near the sample analysis unit, and the display portion of the head amplifier box is extended with a cable so that the RF transmission power information is obtained near the sample analysis unit. An example of an apparatus for performing inspection and maintenance work as shown is shown.

JP 2003-28942 A

  However, in the inspection and maintenance of the NMR analyzer, it is necessary to use more NMR analysis operation information data in addition to the RF transmission power information. In the conventional NMR analyzer, more operations related to the operation information are required. There is no suggestion of a method for making information data visible near the sample analysis section.

  The present invention has been made in view of such problems, and in the inspection and maintenance work in the sample analysis part such as the probe peripheral circuit, the magnet, and the sample setting part, in the vicinity of the place while performing inspection and maintenance. The purpose of the present invention is to provide an easy-to-use NMR analysis apparatus and method by enabling inspection and maintenance work to be performed by one person by making it possible to see the results of operation information data of NMR analysis. .

  In order to achieve the above object, in the present invention, in an NMR analysis method using an NMR analyzer that analyzes a sample by nuclear magnetic resonance, the data collection conditions necessary for the inspection from a portable display terminal having a display function are set in the NMR analyzer. A step of instructing the console, a step of collecting necessary data of the NMR analyzer in accordance with an instruction of the portable display terminal, a step of transmitting the collected data to the portable display terminal, and displaying the collected data on the portable display terminal It has a step.

  In order to achieve the above object, in the present invention, in the NMR analysis method using an NMR analyzer that analyzes a sample by nuclear magnetic resonance, the data analysis conditions necessary for the inspection from a portable display terminal having a display function are analyzed by the NMR analysis. A step of instructing the console of the apparatus; a step of stopping communication between the portable display terminal and the console when the necessary data of the NMR analyzer is collected by an instruction from the portable display terminal; and the console after data collection Sending a command for enabling the communication function of the portable display terminal, sending the collected data to the portable display terminal, and displaying the collected data on the portable display terminal. is there.

  In order to achieve the above object, in the present invention, in an NMR analyzer equipped with a console unit and a sample analysis unit, communication control means for transmitting and receiving data to and from the console unit, and data collection conditions necessary for the inspection are set in the console. A portable display terminal having a data collection condition instructing means for instructing the data, a data collecting means for collecting the necessary data of the NMR analyzer in accordance with an instruction from the portable display terminal, and the collected data in the portable display It is characterized by comprising data transmission means for transmitting to the terminal.

  In order to achieve the above object, in the present invention, in an NMR analyzer equipped with a console unit and a sample analysis unit, communication control means for transmitting and receiving data to and from the console unit, and data collection conditions necessary for the inspection are set in the console. A portable display terminal having a data collection condition instructing means for instructing the data, a data collecting means for collecting the necessary data of the NMR analyzer in accordance with an instruction from the portable display terminal, and the collected data in the portable display A data transmission means for transmitting to a terminal is provided, wherein the communication control means stops communication between the console and the portable display terminal when collecting data from the sample analyzer. is there.

  In the NMR analysis method and apparatus of the present invention, a method of preparing a portable display terminal having a selection function and a display function of information necessary for inspection and maintenance and performing inspection and maintenance work is adopted. Compared to the conventional method in which a dedicated inspection / maintenance console is installed, this method has a higher degree of freedom of movement, and a portable type such as a general-purpose laptop computer that has a display function and a data processing function should be used. If possible, it is advantageous in terms of ease of construction and cost.

  However, in the analysis, there is a possibility that these portable display terminals become noise sources. For this reason, whether or not it actually becomes a noise source differs depending on the frequency used in the NMR analyzer, the structure, the structure of the portable display terminal used, etc., so it cannot be generally stated. In order to grasp the presence or absence of noise sources, when the NMR analyzer is in normal operation, place the portable display terminal in the operating state near the sample analyzer, and display the sample analysis results and RF signal levels in various operation modes. By grasping whether or not it depends on the presence or absence of a terminal, it is possible to grasp in advance whether or not the mobile display terminal to be used becomes a noise source.

  Further, in the NMR analysis method and apparatus of the present invention, since information related to the operation of the NMR analyzer is collected in the console unit, the information collected in the console unit is used for inspection and maintenance on the portable display terminal. In this case, since it is necessary to exchange data between the console unit and the portable display terminal, this data exchange, that is, communication means may be a noise generation source. The NMR analyzer according to the present invention is provided with a plurality of operation methods of communication means with the portable terminal display device for inspection and maintenance according to the magnitude of the influence of noise.

  According to the present invention, even when measures are taken while approaching a sample analysis unit important for inspection / maintenance and displaying information related to the performance of the sample analysis unit, a communication signal between the console unit and the portable display terminal unit for measurement or It is possible to provide a method and apparatus that are not affected by the noise of the portable display terminal.

  Further, according to the present invention, it is possible to carry out inspection and maintenance such as countermeasures for troubles in the probe peripheral circuit, magnet and sample installation section by one person, and provide a method and apparatus that are easy to use in terms of inspection and maintenance. Can be realized.

  Embodiments of the present invention will be described below with reference to the drawings.

  FIG. 1 shows an NMR analyzer according to the present invention. In the apparatus of the present invention, the portable display terminal 7 is connected to the computer of the console unit 1 so that the operation status of the NMR analyzer can be grasped near the sample analysis unit 2.

  FIG. 1 shows an embodiment in which an inspection is performed by an NMR analyzer having a console unit 1, a sample analysis unit 2, and a portable display terminal 7.

First, the basic configuration and operation of the NMR analyzer will be described. The computer 10 is connected to an RF signal generator 20, an RF reception signal processing circuit 31, and a magnet power supply 40. The computer 10 is composed of a plurality of computers, and analyzes measurement data, monitors the operation state of each part, collects operation history data, generates a pulse sequence generated by the RF signal generator 20, and an RF reception signal processing circuit. 31 has functions such as processing of AD conversion data built in 31 and communication with a portable display terminal. In the magnet power source 40, a magnet 41 composed of a plurality of magnets realizes a function of controlling the spatial distribution of the magnetic field to a desired distribution. It also includes a so-called lock control function for suppressing changes in temporal magnetic field distribution. The RF signal generator 20 generates a high frequency signal and irradiates the analysis sample in the test tube 60 with the high frequency signal (several tens to several hundreds of MHz) via the transmission amplifier 21, the tuning circuit 50, and the probe 51. The analysis sample is excited by the irradiated high frequency signal. When the irradiation of the high-frequency signal is stopped, the high-frequency signal is generated when the analytical sample that has been excited and changed in energy state returns to the original energy state. This high-frequency signal is detected by the probe 51, passes through the tuning circuit 50 and the RF reception signal processing circuit 31, and information on the reception signal is taken into the computer 10. From the RF signal generator 20, a gate signal 22 notifying the measurement timing of the RF reception signal is sent to the RF reception signal processing circuit 31. The portable display terminal 7 is configured to transmit and receive data to and from the console 1 via the communication line 70. Here, the transmission amplifier 21 is provided with an output power and reflected power measurement function. The RF reception signal processing circuit 31 also has an input power measurement function and a function of AD converting the processing signal. By providing the RF received signal processing circuit 31 with an input power measuring function, it is possible to know the presence or absence of the output of the preamplifier 30 even on the console side. If this power measurement function is used, the relationship between the high-frequency irradiation power and the preamplifier output can be examined without interposing the RF reception signal processing circuit 31, so that an abnormality occurrence site can be specified. When monitoring the output of the preamplifier 30, it is also possible to measure by providing a detector immediately after the output of the preamplifier 30 of the sample analyzer. However, since the distance of the signal line can be shortened, in this embodiment, a detector is arranged at the input portion of the RF reception signal processing circuit 31 to perform measurement. If a detector is provided at the input portion of the RF reception signal processing circuit 31, the gain setting of the preamplifier can be simplified.

  The user of the NMR analyzer instructs the computer 10 on the analysis conditions, and in accordance with the indicated analysis conditions, information such as the frequency, amplitude, phase, signal duration, generation timing, and reception timing of the RF signal is generated by the RF signal generator. Send to 20. The RF signal generator 20 is configured to send a high frequency signal to the transmission amplifier 21 at the instructed frequency, phase, duration, and transmission timing, and to control the reception timing by the reception gate signal 22.

  FIG. 2 is a time chart showing aspects of transmission / reception signals. Although it is simplified here for easy understanding, the graph of the actual time chart is often a more complicated pulse train. In general, such an RF signal transmission and reception procedure used for sample analysis is called a pulse sequence, and shows a time change of signals appearing at both ends of the probe 51 during sample analysis. It shows that high-frequency signals appear at both ends of the probe 51 in the order of Sig01, Sig02, and Sig03 with the passage of time. Sig01 and Sig02 are RF signals sent from the transmission amplifier 21 to excite the analysis sample put in the test tube 60. However, in FIG. 2, the amplitudes of Sig01, Sig02, and Sig03 are shown to have no significant difference, but the amplitude of Sig03 is actually several orders of magnitude smaller as will be described later. The nucleus of the analysis sample to be excited is selected at the irradiation frequency, and the excitation state is controlled by the magnitude and duration of the irradiation signal. When the analytical sample excited by the RF irradiation returns to its original energy state, it emits an RF signal, which is called FID (Free Induction Decay). The reception gate signal 22 is controlled to enable the RF reception signal processing circuit 31 at the timing of FID emission. Here, the RF signals of Sig01 and Sig02 have a voltage of several tens to several hundreds volts. The amplitude of the received signal of Sig03, that is, the FID signal varies greatly depending on the sample conditions. It may be in mv order or in microvolt order. In some cases, it is necessary to analyze a signal that is several orders of magnitude smaller than the maximum amplitude component included in the FID signal. In this regard, the operation of the NMR analyzer requires a very high S / N ratio. The analysis results obtained by the NMR analyzer are all arranged in the frequency spectrum of the above FID signal, and information relating to the chemical bond of the analysis sample can be obtained from the frequency at which the peak appears and the magnitude of the amplitude. For this reason, it is important how to distinguish between a plurality of peaks having similar frequencies, and this distinguishable performance is called resolution, which is one of the extremely important performances of an NMR analyzer.

  There are various items of inspection / maintenance of the NMR analyzer, but as effective operation items of the portable display terminal 7 used in the present invention, adjustment of electronic circuits such as the tuning circuit 50 and the preamplifier 30 and the magnetic field / electric field of the sample analyzer・ Inspection for vibration and other interference with the surrounding environment, inspection of signal cable connection abnormality between console unit 1 and sample analysis unit 2, etc. It becomes advantageous as work. In the circuit of the NMR analyzer, a high frequency in the vicinity of 1 GHz may be handled. In the high frequency range, it is difficult to handle in a concentrated circuit, so the adjustment of the electronic circuit will be performed by trial and error to some extent in the actual device, which makes it advantageous to work near the inspection / maintenance part. . For example, in the inspection of the sample analysis section for the presence of interference with the surrounding environment such as magnetic field, electric field, and vibration, if the sound and vibration of the air conditioning system affect the analysis result, the inspector's five senses And the presence or absence of a correlation with the NMR analysis result of the sample at that time is determined. In this case, the situation of sound and vibration is often different between the vicinity of the console unit 1 and the sample analysis unit 2. When abnormal connection of the signal cable occurs by touching the cable or applying some force to the connector, a force that seems to be the cause is applied to the predicted position, and the result is predicted using the portable display terminal 7 By observing in the vicinity of the position, the cause can be identified relatively easily.

  Next, the structure and operation of the portable display terminal 7 will be described.

  FIG. 3 shows the internal structure of the portable display terminal 7. A communication interface 701, a display unit 703, and a peripheral device 704 that communicate with the console unit via the communication line 70 are provided, and a CPU (central processing unit) 702 that controls these components is provided. The peripheral device 704 includes a general personal computer peripheral device such as a hard disk or a CD drive. In one embodiment of the present invention, the portable display terminal 7 can be a general notebook computer.

  Next, the operation of the portable display terminal 7 will be described using the flowchart of FIG.

  In this embodiment, a case where a communication line of a portable display terminal becomes a problem as a noise source by a prior test is shown. The flowchart of FIG. 4 shows the flow of the inspection / maintenance data monitor program incorporated in the portable display terminal 7.

Hereinafter, it demonstrates along the step of a flowchart.
(S001) In step 001, the data monitor program is started.
(S002) In step 002, the data monitor program is started in accordance with an external command.
(S003) In step 003, a menu selection waiting screen is displayed. In this menu selection, a tuning mode, an analysis mode, a signal monitor mode, and other modes can be selected.
(S005) When the tuning mode is selected in step 005, the frequency characteristic of the circuit system is displayed, and the frequency characteristic of the reflected power of the transmission amplifier 21 and the frequency characteristic of the input signal amplitude of the RF reception signal processing circuit 31 are displayed. It becomes like this. In this mode, the NMR analyzer can use a plurality of types of probes, and it is possible to select and adjust conditions such as probe selection, frequency range to be swept, and power of the transmission amplifier 21.
(S006) When the analysis mode is selected in step 006, this analysis mode is a mode for analyzing the sample that is actually set, and an irradiation pulse called a pulse sequence as shown in FIG. It is possible to set the same conditions as the actual machine analysis, such as the selection of the reception timing, the selection of the probe used, and the temperature condition of the sample.
(S007) When the signal monitor mode is selected in step 007, in this signal monitor mode, the output power and reflected power of the transmission amplifier 21 and the time variation of the input amplitude and output amplitude of the reception signal processing circuit 31 are monitored. Yes, the condition can be set by selecting the type, frequency, output power, etc. of the probe to which the RF wave is applied. In addition, regarding communication conditions among the condition settings, tuning mode and signal monitor mode are defaulted to "Do not disconnect the communication line while collecting information", and only the analysis mode is "Disconnect the communication line while collecting information" To do ".
(S008) When the other mode is selected in step 008, as an example of this mode, a mode for performing a self-diagnosis of communication between the portable display terminal 7 and the console 1 is executed in the next step 009. The condition is not set.
(S010) In step 010, when any of the tuning mode, analysis mode, and signal monitor mode is selected, the portable display terminal 7 sets the operation mode and the execution conditions as necessary, and then sets the console unit 1 These pieces of information are sent to and instructed to execute processing in the designated operation mode.
(S011) In step 011, the portable display terminal 7 waits until the console unit finishes a series of processes.
(S012) Step 012 is processing when forced termination is selected in step 011. In this case, the processing returns to the first processing step.
(S013) In step 013, the portable display terminal 7 receives result data from the console unit. At this time, in the analysis mode, the communication function is recovered and information is collected using the communication line.
(S014) In step 014, the portable display terminal 7 displays the result data from the console unit, and transmits / receives supplementary data to be described later to / from the console unit.

  Next, a time flow of setting information and inspection data transmission / reception processing between the portable display terminal 7 and the console unit 1 shown in the flowchart of FIG. 4 will be described with reference to FIG.

  In this embodiment, the analysis mode is selected. The timing of each operation of the portable display terminal 7 and the console unit 1 is described. The RF system operation timing indicates the operation of the RF transmission / reception system for inspection. Here, the transmission of the RF signal and the reception of the FID signal are collectively shown as one timing. At the first operation timing of the portable display terminal 7, as shown in the embodiment of FIG. 4, the portable display terminal 7 selects the inspection mode and selects the inspection condition. Then, the setting information is transmitted to the console unit 1. After receiving the information transmitted from the portable display terminal 7, the console unit 1 sets inspection conditions and transmits and receives RF signals.

  The example of FIG. 5 shows an example in which transmission / reception is performed a plurality of times and an average of the FID signal spectrum is obtained. The console unit 1 transmits the result to the portable display terminal 7 after completing the collection and processing of the inspection data by the RF transmission / reception. At the second operation timing of the portable display terminal 7, the inspection data transmitted from the console unit 1 is received and displayed on the terminal, and related information is requested from the console unit 1 as necessary to obtain supplementary data. As supplementary data, for example, the temperature of the sample, the frequency of the lock control system of the magnetic field, and the like are received.

  The embodiment of FIG. 6 shows the temporal flow of transmission / reception processing in the tuning mode and signal monitor mode. At the inspection execution timing of the console unit 1, in the tuning mode, a transmission frequency sweep operation is performed, and the relationship between the reflected power from the probe 51, the magnitude of the transmission power of the transmission amplifier 21, and the frequency is monitored. In the signal monitor mode, the output power and reflected power of the transmission amplifier 21 and the time variation of the input amplitude and output amplitude of the reception signal processing circuit 31 are monitored. In the embodiment of the present invention, since the communication function is not disconnected in these modes, the communication function is valid even during the collection of examination data.

  In this embodiment, the communication of these information uses an Ethernet (registered trademark) cable as the communication line 70 between the console unit 1 and the portable display terminal 7 and realizes one-to-one communication in the local area network. In the apparatus according to the present embodiment, one-to-one communication is performed so that no signal flows on the Ethernet cable except during communication.

  Furthermore, in the analysis mode, after the execution instruction, the mobile terminal 7 waits for reception without communicating with the console unit 1. As a result, no communication signal flows through the communication line 70 during analysis for inspection, so that no noise is placed on the RF signal transmission / reception system. At the stage where the processing end information is obtained from the console 1, the signal processing necessary for the analysis has already been completed, so there is little possibility of noise due to communication.

  In the tuning mode and the signal monitor mode, it is possible to display changes in collected data from time to time while collecting information, which is convenient when trial and error adjustment is performed. The portable display terminal 7 can be forcibly terminated depending on the situation even after an execution command is given to the console unit 1. When the process is completed in the console unit 1, information on the processing result is sent from the console unit 1 to the portable display terminal 7. The inspector or operator who operates the portable display terminal 7 determines the situation by looking at the sent result. As described above, the processing result is obtained such as the frequency characteristics of the signal, the spectrum obtained as the analysis result of the sample, and the temporal variation of the signal amplitude.

In the NMR analyzer equipped with the portable display terminal 7 having the above configuration, the portable display terminal 7 can be used effectively when an abnormality is found in the analysis result. In an abnormal case, the FID cannot be observed at all, or the spectrum spreads and the resolution decreases or a peak appears at a frequency that does not appear originally. In order to investigate the cause, it is often necessary to perform some trial-and-error measures or observation near parts that are considered relevant.

  For example, in the case of manual tuning of the probe 51, normally, two variable capacitors are provided in the tuning circuit 50 for tuning and can be adjusted by turning these dials. This adjustment is more surely performed in the actual analysis state such as the probe 51 and the test tube 60 containing the analysis sample. For this reason, the transmission frequency is swept by the console unit 1 while turning the tuning dial of the two variable capacitors usually installed at the lower part of the sample analysis unit 2, and the level of the reflected wave from the tuning circuit 50 at that time is monitored. . If such a tuning operation is carried out, the frequency characteristics that change according to the rotation of the tuning dial can be directly seen, so that it is easy to predict which dial should be rotated in which direction next. Since it is easy to predict and can be adjusted many times, the reflected wave can be made smaller and the quality of the adjustment can be improved. In addition, since the result is immediately known, the total time required for adjustment is shortened. Note that manual tuning performed near the sample analyzer 2 is particularly effective when there is a problem with a model without automatic tuning or an automatic adjustment function.

  In addition, the mobile display terminal 7 uses metal for its internal components, and a change in the static magnetic field may affect the analysis result during inspection / maintenance work. It is considered that the influence exerted on the analysis result is small when the portable display terminal 7 is placed in a place where the static magnetic field strength is small. In this embodiment, it is possible to determine the installation position of the form display terminal 7 by measuring the static magnetic field intensity around the sample analysis unit in advance. In this case, in order to correspond to the inspections of various NMR analyzers, if a static magnetic field measuring instrument is attached to the portable display terminal 7 and the installation position of the portable display terminal 7 is determined while grasping the static magnetic field strength. It is more mobile and gives better analytical results.

  In the first embodiment described above, serial communication using an Ethernet cable is used as the communication form of the communication line 70, but serial communication such as RS232C or parallel communication using a plurality of signal lines is also applicable. In addition, the portable display terminal 7 may be one that is more strongly electromagnetically shielded than a commercially available notebook computer. Furthermore, various electronic devices can be used as long as they are portable and capable of displaying and communicating in addition to a notebook computer. In order to prevent noise generation from the form display terminal or communication line 70, communication is stopped when measuring the FID signal. However, a dedicated communication line is arranged between the portable display terminal 7 and the console 1, and communication is performed only at the timing of FID generation. Even if the operation is stopped, it is possible to prevent noise generation. Further, although a wired line is used as the communication line 70, it is possible to employ a procedure for stopping communication at the time of FID measurement even in the case of wireless. Further, if infrared communication or optical communication is used, there is a further advantage in that a communication stop procedure is not necessary.

  According to the above embodiment, it is configured to be able to inspect without stopping communication except in the analysis mode. For example, when the communication signal becomes a problem as noise in the signal monitor mode, the analysis is performed in other than the analysis mode. As in the case of the mode, it is possible to stop communication and resume communication after obtaining the inspection signal to be monitored by the console unit 1.

  In the present embodiment, the transmission amplifier 21 has an output power and reflected power measurement function, and the RF reception signal processing circuit 31 also has an input power measurement function, but this is not always essential. For example, the probe tuning can be realized by monitoring only the reflected power, and the present invention can also use a signal useful for inspection / maintenance incorporated in the NMR analyzer body even in the portable display terminal 7. It is a feature. Further, since the signal passing function is provided through the console, the signal processing function of the console unit 2 can be used, which is advantageous in that it is not necessary to locally arrange functions such as a frequency analysis function. is there.

  As described above, according to the embodiment of the present invention, a commercially available notebook personal computer can be used as a portable display terminal, and further, by providing the portable display terminal with the above-described program, the economy can be improved. Become.

  Next, a second embodiment of the present invention will be described with reference to the drawings. The overall configuration is the same as in FIG. 1, and the operation of the main signal is the same as in FIG. The case where both the portable display terminal main body and the communication line become a problem as a noise source by a prior test is shown.

  The structure and operation of the portable display terminal 7 will be described. FIG. 7 shows the internal structure of the portable display terminal 7. A communication interface 701 for performing communication with the console unit via a communication line 70 made of an Ethernet cable, a display unit 703, a CPU (central processing unit) 702 for controlling the peripheral device 704, and the peripheral device 704 are the same as in FIG. It is. In addition, the power supply circuit 72 which abbreviate | omitted description in FIG. 3 was specified.

  The difference from FIG. 3 is that a power control circuit 71 is added. The power control circuit 71 controls the power on / off of the portable display terminal 7. The power control circuit 71 includes a built-in on / off relay for the power supply circuit 72, and this relay is turned on / off from the console unit 1 by a voltage signal. The communication line 70 consists of four pairs of lines, of which two pairs are used for transmission and reception, while the other two pairs are unused. A voltage signal is applied to a pair of unused lines from the console unit 1 to control the ON / OFF relay of the power supply circuit 72.

  In the present embodiment, the portable display terminal 7 uses a general notebook personal computer, but the power control circuit 71 is newly manufactured and added, and can be realized by a relatively simple modification.

  The operation of the portable display terminal 7 will be described using the flowchart of FIG.

  As described above, the present embodiment shows a case where the portable display terminal 7 and the communication line 70 are each problematic as a noise source by a preliminary test.

  The flowchart of FIG. 8 shows the flow of the inspection / maintenance data monitor program incorporated in the portable display terminal 7. Steps 201 to 209 are the same as those in the flowchart of FIG. When this inspection / maintenance data monitor program is started, the menu selection waits at the first start of the program. In menu selection, tuning mode, analysis mode, signal monitor mode, and other selections are possible. In this embodiment, Ethernet is used as a means for communicating these information, as in the first embodiment.

(S211) In step 211, after sending the operating conditions to the console unit 1 and issuing an activation command, data is saved in the hard disk and the power of the portable display terminal 7 is turned off in preparation for restart. For example, when a window XP which is an OS (operating system) is used, an operation of saving data in the hard disk and powering off is called powering off in the hibernation state. General commercial software can be used for the operation command for shifting to the hibernation state.

The console unit 1 collects data of the NMR analyzer based on the operating conditions and the startup command, and when it is ready to transmit data to the portable display terminal 7, it starts the power-on command and subsequently data transmission. . In the mobile display terminal 7, the power control circuit 71 receives the power-on command and turns on the power of the mobile display terminal 7. In the present embodiment, the power-on voltage signal is transmitted using a pair of unused wires in the Ethernet cable. Therefore, even if the power-on function is added, it is not necessary to route a new signal line.
(S213) In step 213, the portable display terminal 7 restarts.
(S214) In step 214, the saved data of the portable display terminal 7 is restored.

When receiving a power-on signal from the console unit 1, the portable display terminal 7 restores the data saved in the hard disk in step 212 in order to return the portable display terminal 7 to the state immediately before the power-off. Note that the restoration of the saved data does not require any programming because the OS itself has the function when using the OS such as the window XP.
(S215) In step 215, the portable display terminal 7 receives the result data.

Next, the portable display terminal 7 receives the inspection data sent from the console unit 1.
(S216) In step 216, the portable display terminal 7 displays the result data.

  Next, the portable display terminal 7 displays the inspection data sent from the console unit 1 and further obtains supplementary data from the console unit 1 as necessary. This obtaining procedure is the same as in the embodiment of FIG.

  In the NMR analyzer provided with the portable display terminal 7 having the above configuration, the portable display terminal 7 can be used effectively when an abnormality is found in the analysis result. In the case of abnormalities, FID may not be observed at all, but the spectrum spreads and resolution decreases, and peaks appear at frequencies that do not appear originally. In order to investigate the cause, it is often necessary to perform some trial-and-error measures or observation near parts that are considered relevant.

  For example, even if the air-conditioning outlet of the room where the sample analysis unit 1 is placed does not directly face the vicinity of the sample, it hits the structural material of the sample analysis unit 1 and hits the installation position of the test tube 60. There is a possibility that slight vibration is induced in the test tube 60. This can happen if the climate when the NMR analyzer is installed is different from the climate when the problem occurs. In this case, since a very slight difference in wind flow is the cause, it is difficult to grasp the situation unless it is near the position of the test tube 60. A slight vibration of the test tube 60 may cause a symptom in which a frequency peak that does not originally appear in the FID spectrum appears. However, this phenomenon is a symptom that can occur even when the uniformity of the magnetic field is poor. In this case, it is assumed that there is a cause in the vicinity of the test tube 60. For example, when the test tube 60 is blown or not hit, the test tube 60 is cleaned and reattached to the installation location. If measures are taken around the unit and the results can be seen immediately, the situation can be grasped and confirmed more quickly and reliably than when working near the console unit 1. As described above, the problem of noise when monitoring the situation can be avoided conventionally, which is extremely effective for such inspection and maintenance work.

  In the second embodiment described above, as in the case of the first embodiment, the portable display terminal is not limited to a so-called notebook personal computer, and can be used if it is portable and has a display function. It is. In the present embodiment, power-on of the mobile display terminal 7 is realized by wire, but a similar mechanism can be provided in the case of wireless communication. Specifically, only the power for the wireless receiving part is always turned on so that only the reception signal processing system is operable, and when a wireless signal carrier is detected or when predetermined power-on information is received wirelessly. A mechanism for turning on the power supply of the entire portable terminal display device 7 may be added. In this case, if only the communication interface 701 and the power control circuit 71 are disconnected from the portable display terminal 7 and the power supply system to reduce the radiation electromagnetic field of the portable terminal display device 7, wireless power-on control can be performed. In the case of infrared rays, power-on control is possible with almost the same configuration. Furthermore, in order to suppress the electromagnetic field generated from the mobile display terminal 7, the power source of the mobile display terminal 7 is basically operated using a battery that is a DC power supply instead of an AC power supply.

  In the embodiment described above, power-off for shifting to the hibernation state is performed. Since the mobile display terminal 7 can be completely powered off by shifting to the hibernation state, this is a desirable method in that noise generated from the mobile display terminal 7 is completely eliminated. However, there is a drawback that the restart time is slow. In order to avoid this, there is a method of powering off in the standby state instead of the hibernation state. This is a system in which the power is turned off while retaining the stored contents of the memory, and only the power supply of the memory portion remains on. According to this configuration, it is possible to restart more quickly, but there is a possibility of an influence of noise generated from the power supply of the memory portion. If the generated noise does not become a problem, it can be adopted by replacing the command for power off shown in FIG. 8 with a command for shifting to the standby state.

  As described above, according to this embodiment, a commercially available notebook personal computer can be used as a portable display terminal, and the influence of noise from the portable display terminal and communication line on the NMR analyzer can be eliminated by adding a simple power control circuit. Furthermore, since the program to be provided in the portable display terminal is very similar to the program used in the console unit, it can be realized with a slight program change.

  In addition, the noise radiated to a normal NMR analyzer is about 125 MHz or less in wired Ethernet, so that the noise level equivalent to the signal handled by a high-resolution NMR analyzer of about 900 MHz enters the analysis side. However, since the frequency of the signal and the frequency of the noise are different, there is no problem. In the case of a wireless system, since the carrier is several GHz, it is greatly different from several hundred MHz handled by a high-resolution NMR analyzer. The received signal processing circuit contains many filters and does not cause a problem because it has a structure that does not pass outside the target frequency range. However, as a condition that does not cause a problem in this way, it is premised that the noise is the same level as the signal level measured by the NMR analyzer, and if the noise is so large that the preamplifier is saturated, it cannot be amplified. It becomes a problem. Therefore, when saturation of the preamplifier becomes a problem, when NMR analyzers with a wider frequency resolution are targeted, or when NMR analyzers that can obtain sample information different from conventional ones are subject to inspection Since the frequency of the signal and the noise may be close to each other, the noise countermeasure shown in this embodiment is required.

The block diagram of the NMR analyzer provided with the portable display terminal by 1st Embodiment of this invention. The example of the time chart of the NMR analyzer main signal by 1st Embodiment of this invention. The block diagram of the portable display terminal by a 1st embodiment of the present invention. The procedure of the test | inspection using the portable display terminal by 1st Embodiment of this invention. The timing diagram of the process of the analysis mode of 1st Embodiment of this invention. The timing diagram of the processing of tuning and waveform monitor mode of the first embodiment of the present invention. The block diagram of the portable display terminal by 2nd Embodiment of this invention. The procedure of the test | inspection using the portable display terminal by 2nd Embodiment of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Console part, 2 ... Sample analysis part, 7 ... Portable display terminal, 10 ... Computer, 20 ... RF signal generator, 21 ... Transmission amplifier, 22 ... Gate signal, 30 ... Preamplifier, 31 ... RF reception signal processing circuit, 40 ... Magnetic power supply 41 ... Magnet 50 ... Tuning circuit 51 ... Probe 60 ... Test tube 70 ... Communication line 71 ... Power control circuit

Claims (12)

In an NMR analysis method using an NMR analyzer for analyzing a sample by nuclear magnetic resonance,
Instructing the console of the NMR analyzer with data collection conditions necessary for the inspection from a portable display terminal having a display function;
Collecting the necessary data of the NMR analyzer according to the instructions of the portable display terminal;
Sending the collected data to a mobile display device;
An NMR analysis method comprising a step of displaying collected data on the portable display terminal. In the NMR analysis method of Claim 1,
When collecting the necessary data of the NMR analyzer by instructions from the portable display terminal,
Stopping communication between the portable display terminal and the console;
And a step of sending a command for enabling the communication function of the portable display terminal from the console after data collection. In the NMR analysis method of Claim 1,
When collecting the necessary data of the NMR analyzer by instructions from the portable display terminal,
Turning off the main power of the portable display terminal;
Sending an instruction to power on the portable display terminal from the console after data collection;
An NMR analysis method comprising: a step of enabling the data reception and display function according to a power recovery instruction. In the NMR analysis method of claim 2 or claim 3,
Stopping communication between the portable display terminal and the console during the execution of the step of collecting necessary data of the NMR analyzer by an instruction from the portable display terminal, or turning off the main power supply of the portable display terminal And add
An NMR analysis method comprising a step of restoring a communication circuit and a power source of a portable display terminal according to an instruction from a console after data collection. In an NMR analysis method using an NMR analyzer for analyzing a sample by nuclear magnetic resonance,
Instructing the console of the NMR analyzer with data collection conditions necessary for the inspection from a portable display terminal having a display function;
When collecting the necessary data of the NMR analyzer by instructions from the portable display terminal,
Stopping communication between the portable display terminal and the console;
Sending a command to enable the communication function of the portable display terminal from the console after data collection;
Sending the collected data to a mobile display device;
An NMR analysis method comprising a step of displaying collected data on the portable display terminal. In the NMR analysis method of Claim 5,
When collecting the necessary data of the NMR analyzer by instructions from the portable display terminal,
Turning off the main power of the portable display terminal;
Sending an instruction to turn on the portable display terminal from the console after data collection;
And a step of enabling the data receiving function in response to a power recovery instruction. In an NMR analyzer equipped with a console part and a sample analysis part,
A portable display terminal having communication control means for transmitting and receiving data to and from the console unit, and data collection condition instruction means for instructing the console on data collection conditions necessary for inspection;
The console has data collection means for collecting necessary data of the NMR analyzer in accordance with instructions from the portable display terminal,
An NMR analyzer comprising data transmitting means for transmitting collected data to the portable display terminal. The NMR analyzer according to claim 7, wherein
The NMR display apparatus, wherein the portable display terminal includes power control means for remotely turning on and off the power. In the NMR analyzer of claim 7 or claim 8,
The NMR control apparatus, wherein the communication control unit stops communication between the console and the portable display terminal when collecting data from the sample analysis unit. The NMR analyzer according to claim 8, wherein
The communication control means turns off the power supply when collecting data from the sample analysis unit. In an NMR analyzer equipped with a console part and a sample analysis part,
A portable display terminal having communication control means for transmitting and receiving data to and from the console unit, and data collection condition instruction means for instructing the console on data collection conditions necessary for inspection;
The console has data collection means for collecting necessary data of the NMR analyzer in accordance with instructions from the portable display terminal,
Data transmission means for transmitting the collected data to the portable display terminal;
The NMR control apparatus, wherein the communication control unit stops communication between the console and the portable display terminal when collecting data from the sample analysis unit. The NMR analyzer of claim 11,
The NMR control apparatus characterized in that the communication control means turns off the power source of the portable display terminal when collecting data from the sample analyzer.

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