JP2005326093A - Simplified bioclean room - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a simplified bioclean room which can be inexpensively installed in a short time, capable of maintaining an indoor cleanliness factor at at least class 7 and an indoor safety level at at least P2. <P>SOLUTION: In the simplified bioclean room 10 formed in a short time by partitions, an air supply fan 32 and a main exhaust fan 42 installed in an environment control unit 20 are connected to a control part 60 via inverters 62 and 62. A local air supply fan 18b and a local exhaust fan 50 are connected to the control part 60 via a switch 72 of a biological safety cabinet 18. The control part 60 controls operations of the main exhaust fan 42, an outdoor unit 68, and the air supply fan 32 on the basis of each measured value of a pressure of the room 14 measured by a pressure gauge 64, a temperature and humidity of an air supply compartment 22 measured by a thermohygrometer 66, and an air supply dynamic pressure measured by a dynamic pressure gauge 70. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a simple bioclean room, and more particularly to a simple bioclean room capable of assembling a bioclean room in which the cleanliness of the room satisfies at least class 7 and the biosafety level satisfies at least P2.

  When conducting genetic recombination experiments or pathogenicity experiments using microorganisms in a facility such as a hospital or laboratory, if the air on the work table leaks to the outside, the microbe that is the experimental sample will work. There was a problem of the occurrence of so-called biohazards that were transmitted to the people or spread outside. In addition, if outside air flows into the workbench during the experiment, so-called contamination occurs that contaminates experimental samples that need to be handled aseptically, making it impossible to conduct experiments reliably. there were.

  Therefore, when conducting the above-described experiment, the work table is kept clean by using a biological safety cabinet that isolates the work table from the outside and sterilizes and cleans the air and exhaust of the work table. Thus, aseptic operation can be performed and the worktable can be securely contained, so that it is possible to cope with biohazard and contamination problems.

  By the way, the biological safety cabinets used in these experiments are generally adopted because they are isolated from the outside in a semi-sealed state because they have low infectivity and require high operability for work. Is done. Therefore, in facilities with low external sealability, air inflow and outflow easily occurs between the biological safety cabinet and the outside, and it is said that the problem of biohazard and contamination is surely solved. It's hard to say.

  Therefore, in order to solve the above problems, a bioclean room isolated from the outside with a high degree of sealing is formed in the space in the facility where the biological safety cabinet is installed, and the biological safety cabinet is used in the room. It is preferable to do. And, the biosafety room is used with a biosafety level of at least P2, that is, (1) the usual microbiology laboratory is limited, and (2) experiments that may generate aerosols are performed in the biological safety cabinet. Perform (3) Containment that satisfies the following three points: prohibiting entry of general outpatients during the course of the experiment, and maintaining the room at least in class 7 in accordance with ISO 14644 standards The problem of biohazard and contamination can be effectively solved.

Conventionally, as disclosed in Patent Document 1, a general bioclean room is configured such that a floor on which a biological safety cabinet is installed is isolated from the outside by a highly airtight partition, and an air supply system is provided in the isolated room. And an exhaust system and a local exhaust system. In the air supply system, outside air is taken in by an air supply fan and air-conditioned by air-conditioning means, and then passed through a high-performance filter typified by a high-efficiency particulate air filter (hereinafter referred to as HEPA filter). Bacteria-cleaned air is supplied into the room. In the exhaust system, the indoor air is sucked by an exhaust fan, passed through a HEPA filter, sterilized and cleaned, and then exhausted. In the local exhaust system, air is exhausted from a biological safety cabinet installed indoors through a system separate from the indoor exhaust through a local exhaust fan and a filter. Each of the air supply system, the exhaust system, and the local exhaust system is provided with a damper that adjusts the air flow rate, and maintains a negative pressure in the room so that the biosafety level satisfies at least P2. The opening and closing of these dampers are adjusted so as to satisfy at least class 7, and set to a predetermined air supply amount and exhaust amount.
JP-A-6-249482

  By the way, research related to biotechnology in which the above-described experiments are performed often requires quick start, and the research cycle is short, and various environments are required depending on the contents of the experiment. Therefore, the bioclean room must be able to be installed easily and quickly without requiring much cost, and it must be able to cope with various environments.

  However, the conventional bioclean room disclosed in Patent Document 1 requires many processes such as a partition installation process, a duct assembly process that forms each system, and a fan installation process. For this reason, there was a problem that much labor, time, and cost were required for installation and dismantling.

  Further, in the bio clean room of Patent Document 1, the air volume is adjusted by a fixed damper. However, since the biological safety cabinet is not always used, the pressure in the room every time local exhaust is performed only when it is used. Fluctuates. Since the air volume cannot be automatically adjusted by this pressure fluctuation, it is difficult to maintain the room so as to satisfy at least the biosafety level of P2 and at least the cleanliness of class 7.

  Conventionally, various proposals have been made for simple bioclean rooms that can be installed in a short time. However, with the simple type, it is extremely difficult to stably maintain the room at least at a clean level of class 7 in a state where the room has a negative pressure so that the biosafety level satisfies at least P2 containment.

  The present invention has been made in view of such circumstances, and can be installed in a short time without requiring much cost. Moreover, the indoor cleanliness is at least class 7, and the indoor biosafety level is at least. The purpose is to provide a simple bioclean room that can be maintained at P2.

  In order to achieve the above-mentioned object, the air supply and exhaust in the room formed by assembling a number of partitions is performed through the HEPA filter, and the biological safety installed in the room is achieved in the invention described in claim 1. A simple bioclean room that operates in a cabinet, and after adjusting the temperature and humidity of the outside air taken in by an air supply fan controlled by an inverter with air conditioning means, the air is supplied to the room through the HEPA filter. A main exhaust system that exhausts the room with an inverter-controlled main exhaust fan, a local exhaust system that exhausts the biological safety cabinet with an inverter-controlled local exhaust fan, and the room The cleanliness of the room satisfies at least class 7, and the biosafety level of the room satisfies at least P2. As, characterized in that a control unit for controlling the operation of the air supply fan and the main exhaust fan and is integrated environmental control unit is provided.

  According to the present invention, a simple bioclean room is configured such that an environmental control unit is first installed in a space where a biological safety cabinet is installed in a facility, and then a large number of partitions are assembled to make the space high from the outside. It is formed by isolating with a sealing degree. The environmental control unit includes an air supply system composed of an inverter-controlled air supply fan, air-conditioning means, and a HEPA filter, an exhaust system that exhausts the room with an inverter-controlled main exhaust fan, and an inverter-controlled local system. It is integrated with a local exhaust system that independently exhausts the biological safety cabinet with an exhaust fan. Accordingly, the environmental control unit is installed to connect the main exhaust HEPA filter installed in the room and the main exhaust fan, and to connect the HEPA filter provided in the biological safety cabinet and the local exhaust fan. Only a simple bioclean room can be formed in a short time by supplying and exhausting air through the HEPA filter and working with the biological safety cabinet installed in the room. .

  When using the simple bioclean room formed in this way, the temperature and humidity measuring means and the pressure measuring means provided in the environmental control unit measure the indoor temperature, humidity and atmospheric pressure, and the control unit of the environmental control unit. To control the indoor environment. As a result, in a simple bioclean room, it is possible to stably maintain a room where the cleanliness satisfies at least class 7 and the biosafety level satisfies at least P2. Therefore, the simple bioclean room of the present invention can form a space that can be reliably contained with high cleanliness in a short time and at low cost.

  According to a second aspect of the present invention, in the control unit according to the first aspect of the present invention, the main exhaust gas is maintained so that the chamber is maintained at a negative pressure based on the pressure in the chamber measured by the pressure measuring unit. Pressure control means for controlling the operation of the fan is provided.

  According to the second aspect, in order for the biosafety level of the simple bioclean room to satisfy at least P2, the room needs to be stably maintained at a negative pressure. Therefore, pressure measurement means is installed in a simple bioclean room to constantly measure the pressure in the room, and the pressure control means controls the operation of the main exhaust fan based on the measured value to maintain the room at a negative pressure. I did it. As a result, even if the indoor pressure fluctuates due to the use of the biological safety cabinet, the pressure in the room can be adjusted to a negative pressure so that it can always be maintained stably.

  According to a third aspect of the present invention, when the operation of the air supply fan is started, the pressure control means according to the second aspect of the present invention is operated by fixing the operation of the main exhaust fan at a predetermined rotational speed for a predetermined time. It is characterized by making it.

  According to claim 3, when using the simple bioclean room, it is necessary to adjust the operation of the air supply fan and the main exhaust fan until the room can be maintained at a predetermined cleanliness and pressure. Control by pressure has a lot of time. Therefore, the operation of the air supply fan and the main exhaust fan is not controlled by the pressure in the room but is fixed at a predetermined rotational speed for a certain time after the operation of the air supply fan is started. Thereby, the time for adjusting the room to a predetermined cleanliness and pressure can be greatly shortened.

  According to a fourth aspect of the present invention, when the operation of the air supply fan is started, the pressure control means according to any one of the second or third aspect forces the operation of the local exhaust fan for a certain period of time. It stops automatically.

  According to claim 4, when using a simple bioclean room, it is necessary to operate and adjust the supply air fan and the main exhaust fan until the room can be maintained at a negative pressure and high cleanliness. If the local exhaust fan is operated, not only the pressure in the room becomes unstable, but also the operation using the biological safety cabinet is performed in a state where the cleanliness of the room is low. Therefore, the local exhaust fan is controlled by the pressure control means so as to be forcibly stopped for a certain time after the operation of the main exhaust fan is started. Thereby, the work in the biological safety cabinet can be reliably performed with a predetermined cleanliness and pressure.

  According to a fifth aspect of the invention, the pressure control means according to any one of the second to fourth aspects operates after fixing the main exhaust fan at a predetermined frequency after stopping the local exhaust fan. It is characterized by making it.

  According to the fifth aspect, when the operation of the main exhaust fan is controlled according to the indoor pressure in the control unit at all times, when the local exhaust fan is stopped after the use of the biological safety cabinet, the control unit Therefore, there is a possibility that the air volume from the air supply fan increases and the indoor pressure becomes positive. Therefore, the pressure control means controls the main exhaust fan so that the main exhaust fan is operated at a predetermined frequency for a predetermined time after the local exhaust fan is stopped. As a result, it is possible to prevent the balance between the indoor air supply and the main exhaust from changing due to the stop of the local exhaust fan, resulting in a positive pressure.

  According to a sixth aspect of the present invention, in the control unit according to any one of the first to fifth aspects, the temperature and humidity of the taken-in outside air measured by a temperature / humidity measuring unit is used. An air conditioning control means for controlling the air conditioning means is provided so that the room is adjusted to a predetermined temperature and humidity.

  According to the sixth aspect, the air conditioning control means of the control unit performs air conditioning so that the indoor temperature and humidity become predetermined values based on the temperature and humidity of the outside air taken into the air supply system by the air supply fan. By controlling the means, the air supplied into the room is adjusted to a predetermined temperature and humidity. Thereby, the room can be stably maintained at a predetermined temperature and humidity.

  According to a seventh aspect of the present invention, the control unit according to any one of the first to sixth aspects is based on an air supply dynamic pressure in the air supply system measured by an air supply dynamic pressure measuring means. And an air supply air volume control means for controlling the operation of the air supply fan.

  According to the seventh aspect, in order to stably maintain the room at a predetermined cleanliness and pressure, it is necessary to adjust the air supply from the air supply system so as to be performed with an appropriate air volume. Therefore, in the simple bioclean room of the present invention, the supply air dynamic pressure flowing in the supply system is measured by the supply air dynamic pressure measuring means, and the supply air volume control means based on the measured supply air dynamic pressure. The operation of the fan was controlled. As a result, the operation of the air supply fan is automatically adjusted so that air is always supplied to the room with an appropriate air volume, so that the room is at least clean with a class 7 cleanliness and at least a biosafety level of P2. Can be maintained.

  As described above, according to the simplified bioclean room according to the present invention, the air supply system and the main exhaust that are cleaned by the HEPA filter in the room simply by installing the environmental control unit after assembling the partition and isolating it from the outside. By simply forming the system and the local exhaust system, it is possible to form in a short time a high-performance bioclean room in which the indoor cleanliness is at least class 7 and the biosafety level is at least P2. As a result, it is possible to quickly start research involving biohazards and reduce the cost required for research.

  Hereinafter, preferred embodiments of a simplified bioclean room according to the present invention will be described in detail with reference to the accompanying drawings.

  FIG. 1 is a perspective view showing a configuration of a simplified bioclean room 10 according to an embodiment of the present invention. In addition, although it is indispensable for the structure of a bioclean room, illustration and description regarding an entrance / exit, an anterior room, an air shower, a dressing room, etc. which are not related to the present invention are omitted.

  The simple bioclean room 10 is composed of a number of partitions 12, 12..., And the interior 14 is isolated from the outdoor 16 with a high degree of sealing by assembling these partitions 12, 12.

  A biological safety cabinet 18 and an environmental control unit 20 are installed in the room 14.

  The biological safety cabinet 18 sterilizes and supplies the air in the room 14 by a local air supply fan 18b and a local air supply HEPA filter 18c installed at the lower part of the work table 18a, and supplies the air to the upper part of the work table 18a. Exhaust air passes through the provided local exhaust HEPA filter 18d. As a result, the work table 18a can be maintained in a high clean atmosphere, and air contaminated through the work table 18a can be cleaned and exhausted to the outside. In addition, the biological safety cabinet 18 is provided with an open / close window 18e that is slidable in the vertical direction, so that the work on the work table 18a can be efficiently performed in a semi-sealed state by opening and closing as necessary. it can.

  The interior of the environmental control unit 20 is divided into an air supply section 22 that is an air supply system, a main exhaust section 24 that is a main exhaust system, and a local exhaust section 26 that is a local exhaust system.

  The air supply section 22 has a complicated structure inside the environmental control unit 20, and includes an air supply damper 28, a medium performance filter 30, an air supply fan 32, an air conditioning coil 34 that is air conditioning means, and an indoor 14. When a high airtight damper 36 for shielding the air supply system with a high degree of sealing when disinfecting the air, a HEPA filter 38 for air supply, and an air supply port 40 are arranged, the air supply indicated by the black arrow is provided. A gas system is formed. That is, when the air supply fan 32 installed in the air supply section 22 is operated, the air supply damper 28 is provided on the outer surface of the air supply section 22 and includes a check valve (not shown) for preventing the backflow of air. The outside air is efficiently taken into the air supply section 22 and passes through the medium performance filter 30 to remove large dust and the like. Then, after being supplied to the air conditioning coil 34 and adjusting the temperature and humidity, it passes through the high airtight damper 36 and is supplied to the air supply HEPA filter 38. The air that has been sterilized and cleaned by passing through the air supply HEPA filter 38 is supplied to the room 14 from the air supply port 40 formed in the upper part of the environment control unit 20.

  The main exhaust section 24 is provided with a main exhaust fan 42 therein, and a main exhaust damper 44 having a check valve (not shown) for preventing a backflow of air on the outer side surface. And the main exhaust system which exhausts the interior 14 is formed by connecting the upper surface of the main exhaust section 24 and the main exhaust HEPA filter 46 installed on the ceiling of the interior 14 by the main exhaust duct 48. The The main exhaust HEPA filter 46 is preferably an enzyme HEPA filter. Thereby, it can prevent effectively that the microorganisms which carried out the adsorption process propagate and are contaminated.

  The local exhaust section 26 has a local exhaust fan 50 installed therein, and a local exhaust damper 52 having a check valve (not shown) for preventing a backflow of air on the outer side surface. And the local exhaust system which exhausts the biological safety cabinet 18 is formed by connecting the upper surface of the local exhaust section 26 and the local exhaust HEPA filter 18d of the biological safety cabinet 18 with the local exhaust duct 56. Is done.

  An operation panel 58 for setting the temperature and humidity of the indoor 14, adjusting the pressure of the indoor 14, and turning on / off the operation of the environmental control unit 20 is provided on the external side surface of the environmental control unit 20 on the indoor 14 side. Installed. And the control part 60 installed in the environment control unit 20 has a pressure control means, an air-conditioning control means, and an air supply air volume control means, and controls each operation | movement in the simple bioclean room 10 automatically.

  FIG. 2 is a block diagram showing the configuration of the control system of the simplified bioclean room 10 according to the embodiment of the present invention.

  As shown in the figure, the air supply fan 32 and the main exhaust fan 42 are connected to the control unit 60 via the attached inverters 62 and 62, and the rotational speeds of the fans 32 and 42 are controlled by the control unit 60 and the inverters 62 and 62. Is controlled. On the other hand, the local supply fan 18b and the local exhaust fan 50 are connected to the control unit 60 via a switch 72 disposed in the biological safety cabinet 18, and the local exhaust is operated and stopped by turning on / off the switch 72. Is controlled. Further, the local exhaust fan 50 includes an inverter 62, and the rotation speed is controlled by the inverter 62.

  The pressure gauge 64 that is a pressure measuring unit measures the pressure in the chamber 14 and transmits the measured value to the control unit 60 connected thereto. The controller 60 controls the operation of the main exhaust fan 42 so that the transmitted measurement value becomes a preset negative pressure value, for example, −20 Pa.

  The temperature / humidity meter 66 as temperature / humidity measuring means is installed in the air supply section 22, measures the temperature and humidity of the outside air taken into the air supply section 22, and transmits the measured temperature and humidity to the controller 60. The controller 60 controls the operation of the outdoor unit 68 installed in the outdoor 16 so that the measured value becomes the temperature and humidity set on the operation panel 58, and the temperature is controlled by the air conditioning coil 34 connected to the outdoor unit 68. And the humidity is adjusted.

  A dynamic pressure gauge 70 serving as a supply air dynamic pressure measuring unit is installed on the downstream side of the medium performance filter 30. The dynamic pressure gauge 70 measures the supply air dynamic pressure in the supply air section 22 and transmits the measured value to the control unit 60 connected thereto. The control unit 60 converts the measured supply air dynamic pressure into the supply air volume, and controls the operation of the supply fan 32 based on the converted supply air volume.

  Next, the operation of the simplified bioclean room 10 according to the embodiment of the present invention configured as described above will be described.

  Conventionally, work that is concerned about biohazard and contamination problems, such as genetic recombination experiments for bacteria and the like, and experiments for handling pathogenic bacteria and pathogenic viruses, is performed by a biological safety cabinet 18 that can be supplied and exhausted with locally purified air. It is performed using.

  However, when the biological safety cabinet 18 is installed in a facility such as a hospital or a laboratory, an inflow or outflow of air occurs between the facility vented to the outside and the biological safety cabinet 18. Therefore, it cannot be said that the environment is optimal in terms of biohazard and contamination.

  Accordingly, a bioclean room that satisfies at least Class 7 cleanliness and can contain P2 in the biosafety level is installed in the facility, and the biological environment is maintained in the room 14 where the cleanliness is high and the negative pressure is maintained. It is preferable to work with the safety cabinet 18 for use.

  Conventionally, the work of forming a bioclean room in the facility is (1) a process of assembling the partitions 12, 12... In the space used for experiments in the facility and isolating them with a high degree of sealing, and (2) supplying air to the room 14 (3) a step of forming a main exhaust system for exhausting the room 14; and (4) a step of forming a local exhaust system for exhausting the biological safety cabinet 18. Consists of processes. In particular, the process of forming each system in (2), (3), and (4) involves operations such as fan placement and piping work, which require a lot of time and effort, so that the bioclean room It takes more than a month and a half to form. However, research related to biotechnology in which the above-described experiments are performed needs to be started quickly and is performed in a short cycle, and the environment of the room 14 required by the research theme varies. Therefore, the conventional bioclean room has a drawback that it cannot sufficiently cope with research on biotechnology in terms of time and cost.

  The simplified bioclean room 10 according to the present invention first installs the environmental control unit 20 on the floor used for the experiment in the facility, and then assembles the partitions 12, 12. It is formed by arranging the exhaust duct 48 and the local exhaust duct 56. The environmental control unit 20 includes an air supply section 22 that is an air supply system, and a main exhaust fan 42 and a local exhaust fan 50 are built in. Therefore, the environment control unit 20 is blocked as a main exhaust duct 48 and a local exhaust duct 56. Use of the modified one can reduce the labor and time required for forming the simplified bioclean room 10. Therefore, the time required to form the simple bioclean room 10 can be shortened because the steps (2), (3) and (4) which require a lot of time are required in the process of forming the conventional bioclean room. It can be reduced to 3 days.

  In the simple bioclean room 10 thus installed, the air supply amount and the exhaust amount are adjusted by the control unit 60 of the environmental control unit 20 so that the room 14 is maintained at a negative pressure, and the air supply HEPA filter 38 and the main exhaust gas are maintained. The supply air and the exhaust gas are sterilized and cleaned by the HEPA filter 46 and the local exhaust HEPA filter 18d. Therefore, the interior 14 can be maintained at least at a class 7 cleanliness, and the biosafety level can be contained at a pressure control equivalent to at least P2, more specifically P3. The biosafety level is P3. (1) Use a clean room that is isolated from the outside due to entrance restrictions in the corridor, double doors or air locks. (2) Wash and clean surfaces such as walls, floors, ceilings and worktables. (3) By adjusting the exhaust system, the outside air always flows into the room 14 from the outside. (4) The exhaust from the room 14 is sterilized with a high-performance filter. (5) Experiments are carried out in the biological safety cabinet 18 and animal experiments are carried out in the biological safety cabinet 18 or negative pressure isolator. (6) Recorded in the personnel list This is a containment that satisfies the following six points: Thereby, the biohazard and contamination regarding the experiment mentioned above can be prevented effectively.

  In the simplified bioclean room 10, the room 14 is isolated from the outdoor 16 with a high degree of sealing by the partitions 12, 12,. Therefore, the temperature and humidity in the room 14 vary depending on the temperature and humidity of the supplied air. Therefore, the temperature and humidity of the room 14 in the simple bioclean room 10 are adjusted by measuring the temperature and humidity of the outside air taken into the air supply section 22 with the thermohygrometer 66 installed in the environment control unit 20. Based on the measured temperature and humidity, the outdoor unit 68 is controlled so as to be a value set by the operation panel 58. Thereby, the room 14 can be stably maintained at a predetermined temperature and humidity.

  FIG. 3 is an explanatory view showing each operation state of the simplified bioclean room 10 according to the embodiment of the present invention, and FIG. 3 (A) shows a state where the biological safety cabinet 18 is used. FIG. 3B shows a state where the biological safety cabinet 18 is not used. The white arrows indicate the direction of supply air, and the black arrows indicate the directions of main exhaust and local exhaust.

  In the simple bioclean room 10, the usage of the biological safety cabinet 18 tends to be not high. In addition, since the biological safety cabinet 18 is used in a semi-sealed state from the viewpoint of operability, the biological safety cabinet 18 is opened and closed when the biological safety cabinet 18 is used. The amount exhausted from the local exhaust system varies depending on the degree. Since the biological safety cabinet 18 sucks and exhausts the air in the room 14, the exhaust amount of the whole room 14 changes due to the change in the exhaust amount from the biological safety cabinet 18, and the pressure in the room 14 fluctuates. The biological safety cabinet 18 used in the simplified bioclean room 10 has various environmental settings and performance depending on the contents of the experiment, and the biological safety cabinet 18 is locally exhausted depending on the environmental settings and performance. The amount also changes.

  Therefore, in the simplified bioclean room 10 of the present invention, the pressure in the chamber 14 is measured by the pressure gauge 64, and the operation of the main exhaust fan 42 is controlled so that the measured pressure becomes a preset negative pressure value. 60 to control. That is, the air supply amount of the air supply fan 32 is kept constant, and the operation of the main exhaust fan 42 having a total exhaust amount larger than that of the local exhaust fan 50 is controlled according to the pressure in the room 14. For example, in the simplified bioclean room 10, assuming that the ratio of the amount of air supplied by the air supply fan 32 is set to 100, as shown in FIG. When the ratio of the exhaust amount in the exhaust fan 50 is 30, the operation of the main exhaust fan 42 is controlled so that the ratio of the exhaust amount of the main exhaust system becomes 70. On the other hand, when the local exhaust fan 50 is stopped without using the biological safety cabinet 18 as shown in FIG. 3B, the ratio of the exhaust amount of the main exhaust system is the same as the supply amount. The operation of the main exhaust fan 42 is controlled so as to be 100. In this way, even if the pressure in the room 14 fluctuates abruptly due to local exhaust, the air flow rate of the main exhaust can be adjusted to quickly cope with it, so the pressure in the room 14 is set to a preset negative pressure value. Can be easily and stably maintained. Thereby, in the room | chamber 14 of the simple-type bioclean room 10, the high containment in which the biosafety level satisfy | fills at least P2 can be performed.

  Further, at the time when the operation of supplying and exhausting air is started, the interior 14 does not satisfy the predetermined cleanliness and pressure, and the cleanliness and pressure of the interior 14 become extremely unstable for a while after the adjustment. Therefore, the biological safety cabinet 18 cannot be used immediately after starting operation. In addition, after the biological safety cabinet 18 is used, the cleanliness and pressure of the room 14 become unstable, so that control based on the pressure in the room 14 cannot be stabilized immediately.

  Therefore, in the simple bioclean room 10 of the present invention, the control of the main exhaust fan 42 and the local exhaust fan 50 by the control unit 60 is switched.

  That is, when the operation of the air supply fan 32 is started, the control unit 60 switches the control so that the air supply fan 32 and the main exhaust fan 42 are stopped from being controlled by the pressure in the room 14 and are operated at a predetermined rotational speed. When a predetermined time has elapsed, the control unit 60 switches the control so that the air supply fan 32 and the main exhaust fan 42 are controlled based on the pressure in the room 14. Thereby, after the operation is started, the room 14 can be quickly adjusted to a predetermined cleanliness and pressure.

  When the operation of the air supply fan 32 is started, the control unit 60 forcibly turns off the switch 72 of the biological safety cabinet 18 to forcibly stop the operation of the local air supply fan 18b and the local exhaust fan 50. Switch the control so that When a predetermined time has elapsed, the control unit 60 switches the control so that the switch 72 can be turned on and off. Accordingly, since the use of the biological safety cabinet 18 is forcibly prohibited from the start of operation until the cleanliness and pressure are adjusted, the work of the biological safety cabinet 18 is performed with a high cleanliness. Moreover, it can be performed in a state of reliable containment.

  Further, when the local supply fan 18b and the local exhaust fan 50 are stopped by turning off the switch 72 after using the biological safety cabinet 18, the control unit 60 operates the main exhaust fan 42 at a fixed frequency. To switch the control. When a predetermined time has elapsed, the control unit 60 switches the main exhaust fan 42 to control the operation based on the pressure in the room 14. Thereby, the unstable state of the room 14 after using the biological safety cabinet 18 can be quickly resolved.

  By the way, in order to maintain the cleanliness and pressure of the room 14 stably, it is necessary to adjust the air supply air volume appropriately. For this purpose, it is necessary to measure the supply air volume in a state in which the supply air is less disturbed, and to grasp the accurate supply air volume. In the simple bioclean room 10 of the present invention, the dynamic pressure is measured in a state where the supply air is rectified by the dynamic pressure gauge 70 installed on the downstream side of the medium performance filter 30, so that the structure is embedded in the environmental control unit 20. It is possible to accurately grasp the dynamic pressure of the air supply system composed of Therefore, in the control unit 60, the operation of the air supply fan 32 is controlled based on the accurately measured air supply dynamic pressure, so that the control unit 60 is always automatically adjusted to an appropriate air supply air volume. Thereby, the interior 14 can be stably maintained so that the cleanliness level satisfies at least class 7 and the biosafety level satisfies at least P2.

  In the simple bioclean room 10 described above, the number, shape, and material of each device and member used are not particularly limited.

  The biological safety cabinet 18 is exemplified by a type in which it is cleaned by the local air supply fan 18b and the local air supply HEPA filter 18c and supplied to the work table 18a. However, the biological safety cabinet 18 is not particularly limited. Even the biological safety cabinet 18 that does not locally clean the workbench 18a can be suitably used in the simplified bioclean room 10 of the present invention. Further, even if the biological safety cabinet 18 is not used, a high-performance clean room having a cleanliness level of at least class 7 and a biosafety level of at least P2 can be provided in a short time and at low cost.

The perspective view which showed the structure of the simple type bio clean room which is embodiment of this invention The block diagram which showed the structure of the control system of the simple type bio clean room which is embodiment of this invention Explanatory drawing which showed each driving | running state in the simple type bio clean room which is embodiment of this invention

Explanation of symbols

  DESCRIPTION OF SYMBOLS 10 ... Simple bio clean room, 12 ... Partition, 14 ... Indoor, 16 ... Outdoor, 18 ... Biological safety cabinet, 18a ... Work table, 18b ... Local supply fan, 18c ... HEPA filter for local supply, 18d ... HEPA filter for local exhaust, 18e ... opening / closing window, 20 ... environment control unit, 22 ... air supply compartment, 24 ... main exhaust compartment, 26 ... local exhaust compartment, 28 ... air supply damper, 30 ... medium performance filter, 32 ... supply Air fan, 34 ... Air conditioning coil, 36 ... High airtight damper, 38 ... Air supply HEPA filter, 40 ... Air supply port, 42 ... Main exhaust fan, 44 ... Main exhaust damper, 46 ... Main exhaust HEPA filter, 48 ... Main exhaust duct, 50 ... Local exhaust fan, 52 ... Local exhaust damper, 56 ... Local exhaust duct, 58 ... Operation panel, 60 ... Control unit, 62 ... In Over data, 64 ... pressure gauge, 66 ... Hygrometer, 68 ... outdoor unit, 70 ... dynamic pressure gauge

Claims (7)

A simple bioclean room in which air supply and exhaust in a room formed by assembling a large number of partitions are performed through a HEPA filter, and work is performed in a biological safety cabinet installed in the room,
An air supply system for supplying air into the room through the HEPA filter after adjusting the temperature and humidity of the outside air taken in by an air supply fan controlled by an inverter;
A main exhaust system for exhausting the room by an inverter-controlled main exhaust fan;
A local exhaust system that exhausts the biological safety cabinet with an inverter-controlled local exhaust fan;
A control unit that controls the operation of the supply fan and the main exhaust fan is integrated so that the indoor cleanliness satisfies at least class 7 and the indoor biosafety level satisfies at least P2. A simple bioclean room with an environmental control unit.   The control unit includes pressure control means for controlling the operation of the main exhaust fan so that the room is maintained at a negative pressure based on the pressure in the room measured by the pressure measurement means. The simple bioclean room according to claim 1, wherein:   3. The simplified type according to claim 2, wherein when the operation of the air supply fan is started, the pressure control unit is configured to operate the main exhaust fan while being fixed at a predetermined number of rotations for a predetermined time. Bio clean room.   The said pressure control means forcibly stops the operation of the local exhaust fan for a certain time when the operation of the air supply fan is started. Simple type bio clean room.   5. The simplified type according to claim 2, wherein after the local exhaust fan is stopped, the pressure control unit operates the main exhaust fan with a predetermined frequency fixed. Bio clean room.   The control unit includes an air-conditioning control that controls the air-conditioning unit so that the room is adjusted to a predetermined temperature and humidity based on the temperature and humidity of the taken-in outside air measured by the temperature-humidity measuring unit. A simple bioclean room according to any one of claims 1 to 5, further comprising means.   The control unit is provided with an air supply air volume control means for controlling the operation of the air supply fan based on the air supply dynamic pressure in the air supply system measured by the air supply dynamic pressure measuring means. The simple bioclean room according to any one of claims 1 to 6.

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