JP2005289984A - Hyperlipidemia ameliorating agent comprising patrinia scabiosaefolia - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a drug safely and effectively preventing or ameliorating hyperlipidemia even if taken continuously for a long period. <P>SOLUTION: This drug for preventing or ameliorating hyperlipidemia comprises Patrinia scabiosaefolia. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a preventive or ameliorating agent for hyperlipidemia that is safe even if taken for a long period of time, and belongs to the fields of pharmaceuticals, quasi drugs, and foods.

  In recent years, lifestyle-related diseases such as eating habits, exercise habits, rest, smoking, drinking, etc., which are said to affect the onset and progression of such diseases, have attracted attention. In developed countries, in particular, the rise of hyperlipidemia, obesity, non-insulin-dependent diseases such as type II diabetes, hypertension, etc. It has become a serious social problem that has hindered the maintenance of health and, as a result, has caused soaring national medical expenses.

  Hyperlipidemia is a condition in which lipids in the blood increase, and serum cholesterol and triglycerides are used as a general index for the diagnosis. Hyperlipidemia is classified into hypertriglyceridemia in which serum triglyceride increases and hypercholesterolemia in which cholesterol increases.

  Triglycerides are important as an energy source for animal activity and are absorbed from food or synthesized in the body. Excess triglyceride accumulates as fat around the viscera and subcutaneously, induces obesity, and may promote type II diabetes and hypertension. Moreover, the relationship with hypertriglyceridemia is pointed out also from the relationship with arteriosclerosis.

  Cholesterol is used in vivo as a constituent of cell membranes and as a raw material for certain hormones. Although an increase in serum cholesterol does not all have an adverse effect on the living body, modern people tend to increase more than necessary due to changes in dietary habits. Cholesterol is present in a form bound to lipoproteins in the body. This lipoprotein is classified into chylomicron, VLDL, LDL, and HDL depending on the specific gravity. It is said that an increase in LDL is particularly problematic in hypercholesterolemia, and an increase in LDL cholesterol is said to cause arteriosclerosis and cardiovascular disease.

Considering dietary habits and exercise habits that have attracted particular attention in recent lifestyles, that is, overeating and lack of exercise, the development of drugs that regulate serum triglyceride levels, that is, serum triglycerides, is particularly important among hyperlipidemias. It is desired (see Non-Patent Documents 1 and 2 above).
Hishosou (defeated soy grass) is a product obtained by drying the above-ground parts or whole grasses of the family Opatidae (Patrinia villosa), Ominaeshi (Patrinia scabiosaefolia) and the Brassica family Thlaspi arvense. Otriae (Patrinia villosa) and Ominae (Patrinia scabiosaefolia) have been used as anti-ophthalmic drugs for analgesia and anti-inflammation, but the efficacy of the Brassicaceae Thlaspi arvense is known. Not. In addition, among the high-capacity Shrimp, Otochosushi and Ominae of the Ominae family are also plants that have been used for food since ancient times (see Non-Patent Documents 3 and 4 above).

Edited by Shigehiro Katayama “Transforming lifestyle-related diseases Diabetes, hyperlipidemia, hypertension, obesity” Medical View, May 25, 2000, pp.207-220 Edited by Yoshitomo Oka, “Lifestyle-related diseases: molecular mechanisms and treatment” Molecular Medicine Vol.38, August 31, 2001, p.87, pp.99-107 Yamano Grass Color Encyclopedia, p.66, Shufunotomosha World useful plant dictionary, p.780, Heibonsha

  The objective of this invention is providing the chemical | medical agent which can prevent or improve hyperlipidemia safely and effectively, even if it takes continuously for a long period of time.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that the extract of Hibisou has an action of suppressing an increase in serum triglyceride concentration and serum free fatty acid concentration in hyperlipidemic animals. I found. That is, it has been found that administration of a high-shower extract can prevent and improve hyperlipidemia.

  The ob / ob mice used to obtain the above findings are deficient in leptin, which is closely related to appetite regulation, and is known to develop obesity and hyperglycemia due to overeating. Therefore, it is considered that administration of the high-shower extract is particularly effective for hyperlipidemia caused by overeating.

Aspects of the present invention based on such findings are the following (1) to (4).
(1) A prophylactic or ameliorating agent for hyperlipidemia, characterized by containing Hishoso.
(2) A prophylactic or ameliorating agent for hyperglycerideemia, characterized by containing Hishoso.
(3) A preventive or ameliorating agent for hyperfree fatty acidemia, characterized by containing Hisho-so.
(4) The preventive or ameliorating agent as described above, wherein Hisho-sou is Otomeshi or Ominae.

  The present invention makes it possible to provide an agent for preventing or improving hyperlipidemia that is highly safe and suitable for long-term use.

  As the high show, any one of Otokoeshi, Ominaeshi, and Gumbinazuna can be used, but for the purpose of prevention or improvement of hyperlipidemia, Otokoeshi and Ominaeshi belonging to the Ominae family are preferable, and Otokoeshi is particularly preferable.

  The effective dose of Hisho-sou can be appropriately increased or decreased in consideration of age, sex, etc., but can be generally used in the range of 100 mg to 50 g as an active ingredient equivalent per day for an adult, preferably 500 mg to 30 g. is there.

  In addition to powder, high extract can use an extract. The extract here includes any form such as a herbal extract, a concentrated extract, and a dry extract. The extract can be produced by an ordinary method using water, alcohol (methanol, ethanol, propanol, isopropanol, butanol, etc.), ethyl acetate, acetone, hexane, a mixed solution thereof or the like as an extraction solvent.

  Among the high show, especially Otokoeshi and Ominae, which belong to the Ominae family, are listed in the food book edited by the Edo period, and have been used for food for a long time. It has been confirmed that there is no problem with its safety. Therefore, continuous administration and continuous intake are possible.

  Hishosou can be used to prevent or ameliorate hyperlipidemia, hyperglycerideemia, and high free fatty acidemia. High free acid lipolipidemia is a pathological condition caused by an increase in the concentration of free fatty acid in serum, and specifically, it is said to cause arteriosclerosis and insulin resistance.

  Vitamin, xanthine derivatives, crude drugs, natural products, excipients, pH adjusters, cooling agents, suspending agents, antifoaming agents, viscous agents, within the qualitative and quantitative ranges that do not impair the effects of the present invention Solubilizers, disintegrants, binders, lubricants, antioxidants, coating agents, colorants, flavoring agents, surfactants, plasticizers, fragrances, etc. are mixed in a conventional manner to prepare liquids, tablets, granules Oral or parenteral preparations such as preparations, powders, capsules, dry syrups, chewable tablets, and transmucosal agents.

  Hereinafter, the present invention will be described more specifically with reference to examples and test examples.

Example 1
After chopping the mango shrimp, 10 times the amount of 50% ethanol was added, extracted by heating at about 80 ° C., filtered and the ethanol was distilled off under reduced pressure, and further concentrated to obtain an extract.

Example 2
After mincing the minced shrimp, 10 times the amount of 50% ethanol was added, extracted by heating at about 80 ° C., filtered and the ethanol was distilled off under reduced pressure, followed by concentration to obtain an extract.

Example 3
After cutting the gum binas, 10 times the amount of 50% ethanol was added, and the mixture was extracted by heating at about 80 ° C. After filtration, the ethanol was distilled off under reduced pressure, and further concentrated to obtain an extract.

Test example 1
Ob / ob male mice [6 weeks old, Charles River Co., Ltd.] were used in the experiment. After preliminary breeding for about one week until use in the experiment, it was divided into two groups: a group to which the high-brush extract produced in Example 1 was administered and a control group. Hisho-so extract was orally administered at a dose of 300 mg / kg (as a dry extract) once a day between 16-17. After raising for 8 weeks, blood was collected and serum was separated. In the normal group, C57BL / 6J mice were used, and the same treatment as in the ob / ob mouse control group was performed.

  Triglyceride (abbreviated as TG) and free fatty acid (abbreviated as NEFA) concentrations in the obtained serum were quantified using each measurement kit (Triglyceride G-Test Wako, NEFA C-Test Wako) manufactured by Wako Pure Chemical Industries.

  As shown in Table 1 and FIGS. 1 and 2, the serum TG concentration and serum NEFA concentration of ob / ob mice were significantly increased compared to normal mice, and a hyperlipidemic state was observed. When administered orally to ob / ob mice at a dose of 300 mg / kg (as a dry extract weight) once a day for 8 weeks, the increase in serum lipids is significantly suppressed, and hyperlipidemia is improved. Admitted.

  From the above results, it has been clarified that, by blending Hishoso, it has a preventive or ameliorating action against hyperlipidemia.

  As a result of studies so far, Hisho-so has the effect of not only lowering the triglyceride concentration and free fatty acid concentration in serum, but also preventing it from becoming high, and of course it is a preventive agent for the treatment of hyperlipidemia. It is also useful as an agent.

  In addition, since its action has been confirmed by ob / ob mice lacking leptin, it is considered to be particularly effective in the prevention and treatment of hyperlipidemia caused by overeating, By continually administering and taking quasi-drugs and foods, a healthy person can maintain a state that is unlikely to become hyperlipidemic even if they eat too much. There is an advantage that hyperlipidemia can be treated without extremely restricting food intake.

  Therefore, it is effective for the prevention and improvement of hyperlipidemia, and is expected to be applied to the development of pharmaceuticals, quasi-drugs and foods that are safe for long-term use. For example, it can be considered to provide a health food for a person who is high in triglyceride and is concerned about hyperlipidemia by blending a high-shower extract into tea.

It is a graph which shows the influence which acts on the serum triglyceride density | concentration of an ob / ob mouse | mouth. It is a graph which shows the influence which acts on the serum free fatty acid concentration of ob / ob mouse | mouth.

Claims (4)

  A prophylactic or ameliorating agent for hyperlipidemia, characterized by containing Hisho-so.   A prophylactic or ameliorating agent for hyperglyceridemia, characterized by containing Hisho-so.   A prophylactic or ameliorating agent for high free fatty acidemia, characterized by containing Hisho-so. The prophylactic or ameliorating agent according to any one of claims 1 to 3, wherein the high-capacity is Otoeshi or Ominae in the family Ominae.

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