JP2005289915A - Gel composition for external use and sheet skin care preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a gel composition for external use which enables the production of a sheet skin care preparation for external use excellent in external appearance and a feeling of use. <P>SOLUTION: The gel composition for external use is essentially composed of a copolymer of hydroxylethylacrylamide and a crosslinkable monomer, and a sheet for the skin care preparation is a sheet of the gel composition for external use in shape. Furthermore, the sheet skin care preparation for external use has the sheet for the skin care preparation containing a skin external preparation component. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an external gel composition. The gel composition for external use of the present invention is a composition that can be formed into a sheet shape excellent in strength and usability, and contains a skin external preparation component such as cosmetics or pharmaceuticals, and is used by being applied to the skin. is there.

  In recent years, with the expansion of the range of behavior of cosmetic users, places and times for performing cosmetic acts are diversified. Specifically, with the expansion of the range of social behavior and opportunities for women to go out, the need for cosmetic acts on the go is rapidly increasing, and portability is also required for cosmetics.

  As one of the cosmetics convenient for carrying around, sheet-like cosmetics for the purpose of moisturizing and cleaning are used. The mainstream of sheet-like cosmetics is an impregnated sheet type in which paper, nonwoven fabric, woven fabric or the like is impregnated with a liquid agent such as lotion or washing water.

  In addition to cosmetics, external cooling sheets for the purpose of lowering heat and sheet-form external preparations impregnated with various chemicals are commercially available.

  As these sheet-form external preparations, various sheet-form preparations have been developed for application to the skin or affected areas. However, most of these sheet-form preparations are prepared by applying a preparation obtained by adding a moisturizer or various chemicals to a polymer such as an acrylic acid polymer or polyvinyl alcohol to a support such as paper, nonwoven fabric, or woven fabric. There are problems such as a feeling of blockage and a feeling of crispness during use.

  In addition, these sheet-form preparations have a problem of damage to the application part due to the adhesiveness of the base itself, such as part of the skin and mucous membrane being peeled off together with the base during peeling.

  Under such circumstances, Patent Document 1 provides a gel plate containing carrageenan and galactomannan. This gel plate is improved to some extent with respect to the above-mentioned feeling of use. Moreover, since this gel plate has high intensity | strength, it is supposed that the sheet agent which does not require support bodies, such as a nonwoven fabric, can be produced.

  In the case of a sheet-form preparation, when a support is not used, there is an advantage that the appearance is excellent because a transparency can be produced. In addition, since the stretchability is high and there is no sensation when used, the feeling of use should be greatly improved.

  However, if the gel plate of the aspect which does not use the support body of patent document 1 is used, a remarkable deformation | transformation will occur during a preservation | save and it will be difficult to maintain the outstanding usability | use_condition.

  Further, Patent Document 2 has developed a cosmetic pack obtained by drying and rolling a thin film forming substrate made of konjac gel, carrageenan and hydrolyzed gelatin. Since this thin film-forming substrate is a dry product, it has excellent storage stability, but has a low intensibility compared to the gel plate, so that the feeling of use is greatly inferior. Moreover, even if moisture is added to the dried product, the surface remains hydrated and the original flexibility of the gel cannot be obtained, and the feeling of use due to the addition of moisture is slight.

  On the other hand, a sheet containing a polyacrylamide derivative, agar and sodium chloride (Geliperm wet, Geistlich, Switzerland) has also been developed as a transparent gel sheet that does not require a support such as a nonwoven fabric.

  In order to improve the above-mentioned problems, the applicant of the present invention provides a sheet-like gel composition in which a thickening polysaccharide (high melting point gelling agent) is blended with carrageenan and / or mannan as a gelling agent having a melting point of 80 ° C. or higher. Developed (Patent Document 3).

JP 60-246314 A JP-A 63-301805 JP 2002-87793 A

  As a result of intensive studies in view of the above-mentioned viewpoints, the present inventors have used a gel composition for external use substantially consisting of a copolymer of hydroxyethylacrylamide and a crosslinkable monomer as a sheet base, and has a high melting point. The present inventors have found that a sheet-form skin external preparation excellent in appearance and usability can be provided without requiring a gelling agent, and have completed the present invention.

  The present invention is excellent in appearance and feeling of use, has high storage stability, is easy to manufacture, is excellent in safety, and does not require a support such as a conventional nonwoven fabric and a sheet form using the same. It aims at providing a skin external preparation.

  That is, the present invention provides an external gel composition substantially consisting of a copolymer of hydroxyethyl acrylamide and a crosslinkable monomer.

  The present invention also provides the above external gel composition, wherein the crosslinkable monomer is N, N′-methylenebisacrylamide.

  Furthermore, the present invention provides the gel composition for external use described above, wherein the crosslinkable monomer unit relative to the hydroxyethylacrylamide unit in the copolymer is 0.1 to 10 mol%. is there.

  Moreover, this invention provides the sheet | seat for external preparations for skin characterized by the shape of said external gel composition being a sheet form.

  Furthermore, the present invention provides the above-mentioned skin external preparation sheet, wherein a support is not laminated on the above-mentioned skin external preparation sheet.

  The present invention also provides a sheet-like external preparation for skin, wherein the external preparation for skin contains a skin external preparation component.

The gel composition for external use of the present invention has substantially no other polymer compound or additive,
Since the sheet | seat excellent in intensity | strength can be substantially formed only with this gel composition, it is a gel composition useful as a sheet agent. And the skin external preparation sheet which has the outstanding external appearance and the outstanding usability can be provided.

  Since the skin external preparation sheet | seat of this invention is excellent in transparency, the sheet-form skin external preparation excellent in the transparency can be provided by containing a skin external preparation component suitably, without requiring a support body. Further, depending on the skin external preparation component to be contained, it can be made opaque or translucent, so that a sheet-like skin external preparation having an arbitrary appearance can be provided.

  The skin external preparation sheet of the present invention has high storage stability, is easy to manufacture, and is excellent in safety.

  Hereinafter, the present invention will be described in detail.

  In the present invention, the copolymer substantially used as the external gel composition is a copolymer of hydroxyethyl acrylamide and a crosslinkable monomer.

Hydroxyethylacrylamide used in the present invention is represented by the following chemical formula.

  The crosslinkable monomer has at least two polymerizable double bonds in one molecule, and it is essential that a crosslinkable structure can be taken efficiently in a polymerization system with hydroxyethylacrylamide. Examples of such crosslinkable monomers include ethylene glycol diacrylate, ethylene glycol dimethacrylate, polyoxyethylene diacrylate, polyoxyethylene dimethacrylate, diethylene glycol dimethacrylate, trimethylolpropane triacrylate, N, N'- Examples include methylene bisacrylamide, N, N′-ethylene bisacrylamide, triallyl isocyanurate, pentaerythritol dimethacrylate, and the like, and one or more selected from these can be used. In the present invention, N, N′-methylenebisacrylamide is particularly preferably used.

  The crosslinkable monomer unit relative to the hydroxyethylacrylamide unit in the copolymer of the external gel composition is preferably 0.1 to 10 mol%. A copolymer prepared at less than 0.1 mol% has insufficient strength as a support for a sheet-like gel and may not be suitable as a support. In addition, the copolymer adjusted to exceed 10 mol% has sufficient gel strength but may be fragile even if it is brittle, and therefore may not be suitable as a sheet-like support.

  As a polymerization method for copolymerization, polymerization may be performed by a known polymerization method such as a solution polymerization method, a suspension polymerization method, a bulk polymerization method or the like. The polymerization initiator is not particularly limited as long as it has the ability to initiate radical polymerization. Examples thereof include benzoyl peroxide, azobisisobutyronitrile, potassium persulfate, and ammonium persulfate.

  The copolymer of hydroxyacrylamide and the crosslinkable monomer can have any shape depending on the shape of the polymerization vessel. Not only the sheet shape but also a shape with a certain thickness such as a puff, a spherical shape, and the like are possible, but the sheet shape is preferable. This copolymer can form a sheet that can be used as a sheet-like external preparation for skin, without laminating other support such as a nonwoven fabric, using substantially only the copolymer as a material. Therefore, it is extremely useful as a sheet agent. Furthermore, the sheet for external preparation for skin of the present invention is not only excellent in appearance and feeling of use, but also has excellent properties for use as a sheet-form external preparation for skin (for example, it is difficult to deform and it is difficult to release water). have.

The external gel composition of the present invention consists essentially of the above copolymer itself, and when used as a sheet agent for forming a sheet, it is not necessary to add other compounding components.
However, even if other additives and copolymers are included, they are not excluded from the scope of the present invention as long as the main component constituting the gel is the copolymer. For example, in addition to a copolymer of hydroxyacrylamide and a crosslinkable monomer, other polymer compounds (thickeners, gelling agents, etc.) such as xanthan gum, carboxyvinyl polymer, polyvinyl alcohol, alginic acid, gum arabic Gelatin, tamarind gum, polyacrylic acid, polyacrylamide, pectin, cellulose derivatives (methylcellulose, carboxymethylcellulose, etc.) and the like can be contained as needed.

  The external gel composition of the present invention can be provided with an optional component to be blended in the skin external preparation, for example, a base component such as water or a moisturizing agent or a pharmaceutical component, thereby providing a sheet-form external preparation for skin. That is, the present invention can optionally contain medicinal ingredients that can be used in various external compositions according to specific uses and purposes, as long as the intended effects of the present invention are not impaired.

  The external gel composition of the present invention can be produced by polymerizing together with hydroxyethyl acrylamide and a crosslinkable monomer, an additive such as the above-described polymer thickener, or a skin external preparation component. Depending on the application, volatile oil, non-volatile oil, oil-soluble vitamins and the like can be added after emulsification and solubilization, and for example, a moist feeling can be imparted to the gel composition.

  As described above, the external gel composition of the present invention is preferably used as a sheet-like external composition, with the shape being a sheet. The sheet shape means a flat plate shape, and the thickness is not particularly limited. Usually, it is about 1 mm to 5 to 6 mm. There is an advantage that thin sheets of 1 mm, 2 mm and 3 mm can be formed.

  The gel composition for external use of the present invention has a great feature that there is no need to laminate or add a support such as a non-woven fabric because the strength is sufficient even when formed into a sheet shape, which is the greatest advantage. . In addition, in the sheet for external preparation for skin, wherein the support is not laminated on the sheet for external preparation for skin, the support is a release paper (or release film) that is peeled off when being applied to the skin. It does not mean and does not include this. The release paper may or may not be present, and the shape during storage is not impaired even without the release paper.

  Thus, the sheet for external preparation for skin of the present invention is tough and excellent in flexibility, so there is almost no risk of breaking or deforming on the skin without using a support, and it does not release water. Furthermore, it has an excellent feature of being excellent in usability. Moreover, it is excellent in stability over time and is relatively easy to manufacture.

  In order to process the gel composition for external use into a sheet form, various methods such as a method of filling a container having a desired shape before polymerization and cooling, and a method of solidifying into a block form and then cutting into a sheet form are used. A skin external preparation sheet can be produced.

  The specific product of the sheet-form external preparation for skin is not particularly limited. Since it is excellent in use feeling, it is preferably used as a sheet-like cosmetic material in which use feeling is important. For example, it is suitably used as a basic cosmetic such as a moisturizing sheet, a whitening sheet, a wrinkle-stretching sheet, and an exfoliating sheet, a body moisturizing sheet, and a tanning treatment agent sheet.

  Typical cosmetic ingredients that can contain the gel composition for external use of the present invention in an arbitrary shape or a preferred sheet shape are usually water mixed in cosmetics; glycerin, propylene glycol, dipropylene glycol, Polyhydric alcohols such as 1,3-butanediol; Lower alcohols such as ethanol and propanol; Sugars such as sorbitol, xylitol and mannitol; Preservatives such as paraben, phenoxyethanol and chlorhexidine gluconate; Tocopherol and its derivatives, butylhydroxy Antioxidants such as toluene and pyrosulfite; UV absorbers such as paraaminobenzoic acid derivatives; Moisturizers such as polyethylene glycol and hyaluronic acid; Vitamin C derivatives such as vitamin C and ascorbic acid-2 glucoside, arbutin Whitening agents such as kojic acid; exfoliating agents such as urea, lactic acid and citric acid; anti-inflammatory agents such as tranexamic acid, allantoin and glycyrrhizinate; pH adjustment such as potassium hydroxide (KOH), citrate and acetate Agents; chelating agents; fragrances; amino acids and amino acid salts; collagen; pigments; medicinal ingredients such as placenta extract, ginseng extract, sterol glycosides; inorganic salts such as sodium salts, calcium salts, potassium salts; talc, silica gel, Components according to various purposes such as powders such as zinc oxide and titanium oxide can be mentioned.

  In addition, hydrocarbons such as petrolatum, squalane and microcrystalline wax; esters such as jojoba oil, geirow and carnauba wax; triglycerides such as olive oil and beef tallow; higher alcohols such as cetanol, oleyl alcohol and stearyl alcohol; stearin Higher fatty acids such as acid and oleic acid; silicones such as dimethylpolysiloxane, dimethylpolysiloxane cyclic pentamer and polyether-modified silicone; nonionic surfactants such as fatty acid monoglyceride and poxyethylene hydrogenated castor oil; sodium lauryl sulfate; Anionic surfactants such as alkylsulfosuccinates; cationic surfactants such as quaternary alkylamine salts; amphoteric surfactants such as alkylbetaines; alkyl-modified carboxyvinyl polymers Polymeric surfactants such as mers can also be added in a range that does not impair the original purpose.

  Further, an embodiment in which a positive medicinal effect is imparted to the external gel composition in the form of a sheet and used for pharmaceutical use is also a suitable product form of the present invention. In this product form, it is possible to solve the decrease in safety and the complexity of the manufacturing process due to residual monomers, which has been a problem in conventional skin external medicines using polyacrylamide. Furthermore, like the above sheet-like cosmetics, improvements in usability and stability are recognized.

  Specific product forms of sheet-form external preparations for use in medicine include, for example, wound / burn protection sheets formulated with osmotic pressure regulators such as salt, heat-resistant sheets formulated with ethanol and menthol, antihistamines and steroids Anti-itching sheet containing hormones, anti-suppuration sheet containing antibacterials and antibiotics, anti-inflammatory sheet containing anti-inflammatory agents, athlete's foot treatment sheet and tinea treatment sheet containing anti-fungal agents, etc. Can be mentioned.

  In addition to pharmaceuticals that directly act on the skin surface and its periphery as described above, a sheet agent intended for transdermal administration of a drug targeting a site away from the site of application is also mentioned as an aspect of the present invention. be able to.

  Typical ingredients contained when using an external gel composition for such pharmaceutical uses include humectants, osmotic pressure regulators, antihistamines, steroid hormones, bactericides, antifungal agents, nourishing agents, and blood vessel protection. Agents, antioxidants, depigmenting agents, desensitizers, immunomodulators, anti-aging agents, anti-wrinkle agents, sebum absorbents, antibiotics, anti-inflammatory agents, deodorants, softeners, etc. .

  Besides these components, water, hydrocarbons, esters, triglycerides, higher alcohols, higher fatty acids, various fatty acids, and the like listed as blending ingredients of the above-mentioned cosmetics and percutaneous absorption accelerators such as Aison. Various components such as monohydric alcohols, surfactants, lower alcohols, thickeners, preservatives, powders, antioxidants, vitamins, UV absorbers, pH adjusters, chelating agents, inorganic salts, and pigments It can also be contained in an external gel composition used for pharmaceutical use.

  Next, the present invention will be described more specifically with reference to examples. The blending amount in this example is part by mass unless otherwise specified.

"Manufacture of external gel composition and skin external preparation sheet"
Example 1: Sheet for topical skin preparation 5 g of hydroxyethylacrylamide and 0.00667 g of N, N'-methylenebisacrylamide (equivalent to 0.1 mol%) were dissolved in 50 ml of water. The solution was refluxed with nitrogen gas for about 1 hour, 0.02 g of potassium persulfate was added and dissolved, and the solution was poured into a 10 cm × 10 cm × 0.5 cm box container. The mixture was heated to 60 ° C. and polymerized for 6 hours. After completion of the polymerization reaction, the mixture was cooled to room temperature to obtain a sheet-like external gel composition.

Example 2: Sheet for topical skin preparation 5 g of hydroxyethylacrylamide and 0.0667 g of N, N'-methylenebisacrylamide (corresponding to 1 mol%) were dissolved in 50 ml of water. The solution was refluxed with nitrogen gas for about 1 hour, 0.02 g of potassium persulfate was added and dissolved, and the solution was poured into a 10 cm × 10 cm × 0.5 cm box container. The mixture was heated to 60 ° C. and polymerized for 6 hours. After completion of the polymerization reaction, the mixture was cooled to room temperature to obtain a sheet-like external gel composition.

Comparative Example 1: Skin external preparation sheet 5 g of sodium polyacrylate and 0.0082 g (corresponding to 0.1 mol%) of N, N′-methylenebisacrylamide were dissolved in 50 ml of water. The solution was refluxed with nitrogen gas for about 1 hour, 0.02 g of potassium persulfate was added and dissolved, and the solution was poured into a 10 cm × 10 cm × 0.5 cm box container. The mixture was heated to 60 ° C. and polymerized for 6 hours. After completion of the polymerization reaction, the mixture was cooled to room temperature to obtain a sheet-like external gel composition.

Comparative Example 2: Skin external preparation sheet 5 g of sodium polyacrylate and 0.082 g (corresponding to 1 mol%) of N, N′-methylenebisacrylamide were dissolved in 50 ml of water. The solution was refluxed with nitrogen gas for about 1 hour, 0.02 g of potassium persulfate was added and dissolved, and the solution was poured into a 10 cm × 10 cm × 0.5 cm box container. The mixture was heated to 60 ° C. and polymerized for 6 hours. After completion of the polymerization reaction, the mixture was cooled to room temperature to obtain a sheet-like external gel composition.

“Manufacture of sheet-form external preparations”
Example 3: Sheet-form skin external preparation The sheet prepared in Example 1 was dipped in a moisturizing skin external preparation composition having the following formulation to obtain a sheet-form skin external preparation (humidity-retaining sheet) of Example 3.

Example 4: Sheet-form skin external preparation The sheet | seat produced in Example 2 was immersed in the moisturizing skin external preparation composition of the following prescription, and the sheet-form skin external preparation (moisturizing sheet) of Example 4 was obtained.

Comparative Example 3: Sheet-form skin external preparation The sheet prepared in Comparative Example 1 was dipped in a moisturizing skin external preparation composition having the following formulation to obtain a sheet-form skin external preparation (moisturizing sheet) of Comparative Example 3.

Comparative Example 4: Sheet-form skin external preparation The sheet prepared in Comparative Example 2 was immersed in a moisturizing skin external preparation composition having the following formulation to obtain a sheet-form skin external preparation (moisturizing sheet) of Comparative Example 4.

“Prescription of skin moisturizer for moisturizing”
Dipropylene glycol 7% by mass
Polyethylene glycol 1500 8
POE (15) oleyl alcohol ether 1
Ascorbic acid glucoside 2
Caustic potash 0.2
Citric acid 0.01
Na citrate 0.09
Methylparaben 0.2
Ion exchange water

<Evaluation of the moisturizing sheet of the present invention>
Usability and storage stability were evaluated using the sheet-form external preparations obtained in Examples 3 to 4 and Comparative Examples 3 to 4.

"Usage"
Sensory evaluation was performed on the feeling of use of the moisturizing sheet. Five professional panelists use these sheets to provide a refreshing feel, a moist feeling, a moist feeling (negative), and a feeling of skin remaining on the base (negative). The four items were evaluated in five levels, from very good (5 points) to very bad (1 point), and the average value of the evaluations of the five people was used as the score of the sheet.
"Storage stability"
For storage stability, it is sealed in an aluminum laminated pouch and stored at 50 ° C for 1 month. After use, the feeling of use, stability of shape, and the presence or absence of deterioration are comprehensively evaluated by the above five specialist panelists. The average value of 5 levels from very good (5 points) to very bad (1 point) was used as the score of the sheet.

As shown in Table 1, in the sheets of Examples 3 and 4, the refreshing feeling and the moist feeling are excellent, and the feeling of the remaining feeling and the remaining skin of the base are not recognized. It had a good feeling of use.
Such an excellent feeling of use is maintained even after high temperature storage, and there is no problem with the stability of the shape and the presence or absence of alteration. .

  On the other hand, in Comparative Examples 3 and 4, the refreshing feeling of use was poor, and the feeling of use was confirmed, and the feeling of use was impaired. Furthermore, it was found that when stored at a high temperature, there is a problem in storage stability such as deformation of the sheet and water separation, and the usability is impaired.

ADVANTAGE OF THE INVENTION According to this invention, it is excellent in an external appearance and a usability | use_condition, and the gel composition for external use which has a sheet | seat shape without using support bodies, such as a nonwoven fabric, is provided.
The external gel composition of the present invention contains a cosmetic ingredient and is suitable as a cosmetic sheet such as a moisturizing sheet, a whitening sheet, a wrinkle-stretching sheet, an exfoliating sheet, a body moisturizing sheet, a tanning agent sheet, etc. Used for
Also, suitable for medicinal sheets such as wound / burn protection sheets, anti-itching sheets, anti-suppuration sheet, anti-inflammatory sheet, athlete's foot treatment sheet, and beetle treatment sheet for medical use. Used.

Claims (6)

  An external gel composition substantially comprising a copolymer of hydroxyethyl acrylamide and a crosslinkable monomer.   The gel composition for external use according to claim 1, wherein the crosslinkable monomer is N, N'-methylenebisacrylamide.   The gel composition for external use according to claim 1 or 2, wherein the crosslinkable monomer unit with respect to the hydroxyethylacrylamide unit in the copolymer is 0.1 to 10 mol%.   The external gel composition according to any one of claims 1 to 3, wherein the external gel composition has a sheet shape.   The sheet for external skin preparation according to claim 4, wherein a support is not laminated on the sheet for external skin preparation. 6. A sheet-form external preparation for skin, wherein the external preparation for skin contains a skin external preparation component in the sheet for external preparation for skin according to claim 4 or 5.