JP2002348206A - Gel composition and external skin preparation composed thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide technology for controlling gelling and maintaining the quality characteristics of a product, or a dosage form which can maintain the quality characteristics of the product in an external skin preparation containing a methacrylate choline ester polymer and/or its salt. SOLUTION: The external skin preparation, which contains a methacrylate choline ester polymer and/or its salt and an oily component, contains 20 wt.% or more, preferably, 40 wt.% or more of one or more selected from among silicones such as a dimethicone, a cyclomethicone, an amodimethicone, a polyether modified silicone, an acryl modified silicone, a phenyl methicone, and polyhydric alcohols such as a polyethylene glycol, a 1,3-butanediol, a glycerin, a 1,2-pentanediol, an isoprene glycol, and a dipropylene glycol, based on the total amount of oily components thereof.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin, and more particularly, to an external preparation for skin suitable for a gel preparation having excellent viscosity characteristics.

[0002]

2. Description of the Related Art A choline methacrylate polymer called polyoctanium 37 and / or a salt thereof have excellent gel-forming properties, and are utilized in the field of skin external preparations such as cosmetics. Although it is used as an agent, it is commercially available in an oil-dispersed form such as a hydrocarbon or propylene glycol diacylate, and is used in a pharmaceutical system containing an oily component. Although this product has excellent gel-forming properties, its gel-forming properties vary greatly depending on the lot to be manufactured, so that it is not possible to make a product with the expected physical properties, and there is also a large lot difference in physical properties over time, A major challenge remained in maintaining product quality characteristics. For this reason, in the case of a product using this as a gelling agent, it is often necessary to set a reworking step after production, and a solution has been desired. Further, it has been desired to find out the cause of such a phenomenon.

On the other hand, in a skin external preparation containing a choline methacrylate polymer and / or a salt thereof and an oil, one or more selected from silicones and polyhydric alcohols are added to the total amount of the oil for 20 times. Nothing is known about a formulation containing more than 10% by weight, and it is completely known that such a formulation has stable gel-forming properties, is useful for producing a product of stable quality without trouble in production. Had not been.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made in view of such circumstances, and it has been found that a skin external preparation containing a choline methacrylate polymer and / or a salt thereof has a gel-forming property. It is an object to provide a technique for controlling and maintaining the quality characteristics of a product, or a dosage form capable of maintaining the quality characteristics of a product.

[0005]

SUMMARY OF THE INVENTION In view of such circumstances, the present inventors have controlled the gel-forming property of a skin external preparation containing a choline methacrylate polymer and / or a salt thereof to improve the quality characteristics of the product. As a result of diligent research efforts in search of techniques for maintaining the above or a dosage form that can maintain the quality characteristics of the product, a skin external preparation containing a choline methacrylate polymer and / or a salt thereof and an oil component has been found. It has been found that a formulation containing 20% by weight or more of one or more selected from silicones and polyhydric alcohols with respect to the total amount of oil has such characteristics,
The invention has been completed. That is, the present invention relates to the following technology. (1) In a skin external preparation containing a choline methacrylate polymer and / or a salt thereof and an oil, 20% by weight of one or more selected from silicones and polyhydric alcohols with respect to the total amount of the oil. An external preparation for skin characterized by containing the above. (2) The external preparation for skin according to (1), wherein the silicone is 90% by weight or more in one or more kinds selected from silicone and polyhydric alcohol. (3) The external preparation for skin according to (1) or (2), which is in a gel form. (4) It is a cosmetic for hair, (1)
To (3) The external preparation for skin according to any one of the above. (5) The method according to any one of (1) to (4), wherein the choline methacrylate polymer and / or a salt thereof is manufactured by being dispersed in an oil phase in a state of being dispersed in an oil component. External preparation for skin. Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS (1) Choline methacrylate polymer which is an essential component of the external preparation for skin of the present invention and / or
Or a salt thereof The external preparation for skin of the present invention contains a choline methacrylate polymer and / or a salt thereof as an essential component. The choline methacrylate polymer and / or its salt are usually commercially available in the form of a hydrochloride, which is dispersed in an oily component such as liquid paraffin or ester oil. As a specific commercially available product, Salcare SC96 (manufactured by Ciba Specialty Chemicals) dispersed in 50% by weight of propylene glycol (dicaprylate / dicaplate) can be particularly preferably exemplified. Such a choline methacrylate polymer and / or a salt thereof has a property of forming a strong gel by being hydrated. In the present invention, a skin external preparation is preferably applied as a gel preparation containing an oily component utilizing such gel properties. In order to form a gel suitable for such a gel preparation, the choline methacrylate polymer and / or a salt thereof is used in an amount of itself and 0.0% based on the total amount of the gel preparation.
The content is preferably 1 to 5% by weight, more preferably 0.05 to 5% by weight.
2% by weight is particularly preferred. This is because if the amount is too large, the gel hardness becomes too high and the usability as a gel preparation may be impaired. If the amount is too small, gel formation may be insufficient.

(2) Silicone and / or polyhydric alcohol which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains one or more selected from silicone and polyhydric alcohol. It is characterized by the following. Here, as the silicone or the polyhydric alcohol, those usually used in cosmetics can be used without particular limitation. For example, in the case of silicone, dimethicone, cyclomethicone, amodimethicone, femethicone, Polyether-modified methylpolysiloxane,
Acrylic-modified methylpolysiloxane can be preferably exemplified. If it is a polyhydric alcohol, the average molecular weight is 100 to 2
Preferred examples include 0000 polyethylene glycol, 1,3-butanediol, 1,2-pentanediol, polyglycerin such as isoprene glycol, glycerin and diglycerin, and polypropylene glycol such as propylene glycol and dipropylene glycol. These are preferably liquids (having fluidity) under the conditions of 1 atm and 25 ° C. These silicones and polyhydric alcohols are preferably contained so that the total amount thereof is 20% by weight or more, more preferably 40% or more, based on the total amount of the oily (oil phase) component. It is preferable to contain 5 to 50% by weight based on the total amount,
More preferably, it is 10 to 30% by weight. Further, as a combination of silicone and polyhydric alcohol, in the composition of such silicone and polyhydric alcohol, it is preferable that silicone is 90% by weight or more, and it is more preferable that silicone is 95% by weight or more.

(3) External preparation for skin of the present invention The external preparation for skin of the present invention contains the above essential components and is used externally on the skin. The application range of the skin external preparation of the present invention is not particularly limited as long as it is within this range, for example,
Suitable examples include cosmetics and skin external medicines. The skin external preparation of the present invention preferably utilizes the gel properties of the above-mentioned essential components, and from this viewpoint, is preferably applied as a cosmetic for hair, and in particular, a cosmetic for hair for the purpose of hair styling. The external preparation for skin of the present invention may contain, in addition to such essential components, any components usually used in cosmetics or external medicine for skin. Such optional components include, for example, squalane, petrolatum,
Hydrocarbons such as microcrystalline wax, jojoba oil, carnauba wax, esters such as octyldodecyl oleate, triglycerides such as olive oil, tallow, coconut oil, fatty acids such as stearic acid, oleic acid and ritinoleic acid, oleyl alcohol , Stearyl alcohol, higher alcohols such as octyldodecanol, anionic surfactants such as sulfosuccinates and sodium polyoxyethylene alkyl sulfate, amphoteric surfactants such as alkyl betaine salts, and cationic surfactants such as dialkylammonium salts Nonionic surfactants such as fatty acids, sorbitan fatty acid esters, fatty acid monoglycerides, sugar esters, their polyoxyethylene adducts, polyoxyethylene alkyl ethers, and polyoxyethylene fatty acid esters Agents, thickening-gelling agents, antioxidants, ultraviolet absorbers, coloring materials, preservatives, powders, vitamins, preferred examples of the active ingredient and the like, such as whitening agents. Of these, preferred components include cosmetic polymers for hair, cationic polymers such as polydimethylmethylenepiperidinium chloride (polyquaternium-6), cationized cellulose, cationized guar gum, animals, seafood, and the like. Examples thereof include plant-derived collagen, hydrolysates of the collagen, and derivatives obtained by introducing a substituent into them. Among these, a particularly preferred component is polyquaternium-6. This is because the choline methacrylate polymer which is an essential component of the present invention and / or a salt thereof has an action of preferably changing the gel properties. The preferred content of this is 0.01 to 5% by weight, more preferably 0.05 to 1% by weight. As the skin external preparation of the present invention, it can be applied to a gel-like preparation containing an oily component, which makes use of the gel-forming properties of a choline methacrylate polymer and / or a salt thereof, which is an essential component for the preparation. preferable. The external preparation for skin of the present invention can be produced by treating the above components according to a conventional method.

[0009]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

<Example 1> Hair make gel 1 (cosmetic) which is an external preparation for skin of the present invention according to the following formulation:
It was created. That is, the components (a) and (b) were each heated to 80 ° C., and (b) was gradually added to (a) while stirring to emulsify and gel, and then stirred and cooled to obtain a gel composition of the present invention. Note that dimethicone, cyclomethicone, and silicone elastomer (highly polymerized dimethicone) were all substituted with glyceryl triisooctanoate, and polyether-modified silicone and amodimethicone were substituted with polyoxyethylene (60) hydrogenated castor oil. Example 1 was also made. The preparation was performed for each 6 lots, and the viscosity was measured immediately after preparation and after storage at room temperature for one week. (Unit: mPascal / sec) The viscosity was measured with a B-type viscometer. It is clear that the hair make gel of the present invention has a small lot variation and a change with time in the viscosity, and the control example shows that the lot variation, the change with time and the variation with time are remarkable. (A) Dimethicone 2.5 parts by weight Volatile dimethicone 3 parts by weight Highly polymerized methylpolysiloxane 0.2 part by weight Salcare SC96 1 part by weight Polyoctane 6 0.5 part by weight Cetyl isooctanoate 0.3 part by weight Cyclo Methicon 0.8 parts by weight Polyether-modified silicone 0.7 parts by weight Amodimethicone 0.3 parts by weight (b) Cationized cellulose 0.2 parts by weight Hydrolyzed collagen 0.1 parts by weight Ethanol 12 parts by weight Water 78.4 parts by weight Department

[0011]

[Table 1]

<Example 2> Hair make gel 1 (viscosity 6125 mPascal / sec) of Example 1 and Comparative Example 1
(Viscosity: 2950 mPascal / sec), a usability test was conducted by 10 panelists for comparison. In the comparative test, five types of hairstyles were prepared using the respective hair makeup gels, and the hairstyle was easily adjusted. Score 4: very good, score 3: good, score 2: somewhat bad, score 1: Poor, score 0: Judgment was made based on the extremely poor standard. As a result, the average score of hair make gel 1 of the present invention was 3.25, and that of control example 1 was 2.10. This shows that the hair makeup gel of the present invention has excellent usability. In addition, one of the reasons why the evaluation was low in the control example is considered to be low viscosity, and in this sense, it was found that control of viscosity has an important meaning in production,
Also in this sense, it can be seen that the external preparation for skin of the present invention has a stable viscosity in a production lot and has excellent production characteristics.

<Examples 3 to 9> In the same manner as in Example 1, a hair makeup gel of the present invention was prepared according to the following formulation. Table 2 shows the viscosities and variations immediately after the production and the viscosities after storage at 20 ° C. for 1 week and the variations (2 lots) in the three lot production. It can be seen that the skin external preparations of the present invention have little variation in viscosity and little change over time during production and storage. From these results, it is also understood that silicone and polyhydric alcohol have an effect of reducing the variation in viscosity. (A) Component 1 * 5.7 parts by weight Salcare SC96 1 part by weight Polyoctane 6 0.5 part by weight Cetyl isooctanoate 0.3 part by weight Cyclomethicone 0.8 part by weight Polyether-modified silicone 0.7 part by weight Amodimethicone 0.3 parts by weight (b) Cationized cellulose 0.2 parts by weight Hydrolyzed collagen 0.1 parts by weight Ethanol 12 parts by weight Water 78.4 parts by weight * Details are shown in Table 2.

[0014]

[Table 2]

<Examples 10 to 12> Proportion of silicone or polyhydric alcohol in oil component (value of B in Table 3)
And the effect on the viscosity trend was investigated. Table 3 shows the results. From the results, it is understood that in the external preparation for skin of the present invention, the content of silicone or polyhydric alcohol is preferably at least 20% by weight, more preferably at least 40% by weight. (B) Component 2 ** 7.8 parts by weight Salcare SC96 1 part by weight Polyoctane 6 0.5 part by weight (b) Cationized cellulose 0.2 part by weight Hydrolyzed collagen 0.1 part by weight Ethanol 12 parts by weight Water 78.4 parts by weight ** Details are shown in Table 3.

[0016]

[Table 3]

<Example 13> In the same manner as in the above example, a skin external preparation, which is a skin external preparation of the present invention, was prepared. (A) Dimethicone 2.5 parts by weight Volatile dimethicone 3 parts by weight Highly polymerized methylpolysiloxane 0.2 part by weight Salcare SC96 1 part by weight Polyoctane 6 0.5 part by weight Cetyl isooctanoate 0.3 part by weight Cyclo Methicon 0.8 part by weight Polyether-modified silicone 0.7 part by weight Amodimethicone 0.3 part by weight Butenafine 2 parts by weight (b) Cationized cellulose 0.2 part by weight Hydrolyzed collagen 0.1 part by weight Ethanol 12 parts by weight Water 76.4 parts by weight

Example 14 In the same manner as in the above example, a skin external preparation, which is a skin external preparation of the present invention, was produced. (A) Dimethicone 2.5 parts by weight Volatile dimethicone 3 parts by weight Highly polymerized methylpolysiloxane 0.2 part by weight Salcare SC96 1 part by weight Polyoctane 6 0.5 part by weight Cetyl isooctanoate 0.3 part by weight Cyclo 0.8 parts by weight of methicone 0.7 parts by weight of polyether-modified silicone 0.3 parts by weight of amodimethicone 1.5 parts by weight of estradiol 0.5 parts by weight of norethisterone 0.2 parts by weight of cationized cellulose 0.2 parts by weight of hydrolyzed collagen 1 part by weight Ethanol 12 parts by weight Water 76.4 parts by weight

Example 15 In the same manner as in the above Example, a skin external preparation, which is a skin external preparation of the present invention, was produced. (A) Dimethicone 2.5 parts by weight Volatile dimethicone 3 parts by weight Highly polymerized methylpolysiloxane 0.2 part by weight Salcare SC96 1 part by weight Polyoctane 6 0.5 part by weight Cetyl isooctanoate 0.3 part by weight Cyclo Methicon 0.8 part by weight Polyether-modified silicone 0.7 part by weight Amodimethicone 0.3 part by weight Indomethacin 1 part by weight (b) Cationized cellulose 0.2 part by weight Hydrolyzed collagen 0.1 part by weight Ethanol 12 parts by weight Water 77.4 parts by weight

[0020]

According to the present invention, in a skin external preparation containing a choline methacrylate polymer and / or a salt thereof, a technique for controlling the gel-forming property and maintaining the quality characteristics of the product, Dosage forms can be provided that can maintain quality characteristics.

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Claims (5)

[Claims] 1. A skin external preparation containing a choline methacrylate polymer and / or a salt thereof and an oil component,
An external preparation for skin, comprising 20% by weight or more of one or more selected from silicone and polyhydric alcohol based on the total amount of oil. 2. The external preparation for skin according to claim 1, wherein in one or more constitutions selected from silicone and polyhydric alcohol, the silicone is 90% by weight or more. 3. The external preparation for skin according to claim 1, which is in a gel form. 4. The external preparation for skin according to claim 1, which is a cosmetic for hair. 5. The method according to claim 1, wherein the choline methacrylate polymer and / or a salt thereof are produced by being dispersed in an oil phase in a state of being dispersed in an oil component. External preparation for skin.