JP2005205168A - Jet type syringe - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an easily portable jet type syringe suitable for insulin injection for diabetes, gene therapy drug injection, and vaccination. <P>SOLUTION: In this jet type syringe, a nozzle 101B comprising a jet nozzle 104 opening at the distal end, a cylinder 105 communicating with the jet nozzle 104, a drug solution storage chamber 106A formed along the circumference of the cylinder 105, and a ring shape rubber stopper 200 which slides and fits into the drug solution storage chamber 106A by pressure difference between inside and outside of the drug solution storage chamber 106A and is movable blocking an air flow along the axis is detachably connected to the syringe body. Because the drug solution storage chamber 106A is set along the circumference of the cylinder 105, the outer diameter of the whole syringe including a nozzle 101B can be made slim and the storage chamber 106A can store a volume of drug solution more than several times the drug solution which the cylinder 105can store, whereby eliminating the need to carry drug solution vials. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a jet injector that performs insulin injection, gene therapy drug injection, and vaccine injection for diabetes.

The injection type syringe is a syringe that performs subcutaneous injection of a drug solution by jetting the drug solution from a jet injection port provided at the tip of the syringe. In other words, injection with a jet-type syringe is needle-free injection, and there are many advantages such as the possibility of reducing injection marks and pain, and there is no fear of needle stick accidents compared to injection with a needle. It is used not only in medical facilities but also for self-injection on a daily basis by, for example, diabetic patients.
In the conventional injection type syringe, a troublesome operation of sucking a drug solution from a drug solution vial (drug solution container) separate from the syringe every time needle-free injection is performed is necessary. In addition, for diabetics who need to self-inject insulin on a daily basis, they must carry both a syringe and a separate drug vial when they go out, but either a syringe or a drug vial If you forget to carry only one and carry one, you may not be able to beat insulin.

In order to eliminate the drawbacks of the injection type syringe as described above, a cartridge 3 containing a chemical solution as shown in FIG. 10 is arranged around the injection component 1 constituting the tip of the syringe body in parallel in the axial direction. An injection type syringe (for example, Patent Document 1) that is installed in a cartridge housing long hole 6 that is provided and communicates with a cylinder 5 has been devised. In this injection type syringe, since the cartridge 3 can be stored in the injection component 1 in advance, the cartridge 3 and the injection type syringe body can be carried together, and troubles caused by forgetting to carry the cartridge 3 can be eliminated. There is an advantage that it is possible to omit the operation of inhaling the drug solution from the drug solution vial into the cylinder 5 every injection.
JP 2001-340456 A

The conventional injection type syringe is configured as described above, but since the cartridge containing the drug solution is loaded in the peripheral part of the syringe body, the diameter of the syringe body becomes thicker and can be carried and handled during injection. It was inconvenient. Further, the flow path for supplying the chemical liquid to the cylinder becomes long, and the chemical liquid may be easily clogged.
The present invention has been made in view of such a situation, and stores the chemical solution in the injection syringe body in advance, and can inject the chemical solution into the cylinder at the time of injection and perform the injection. An object of the present invention is to provide an injection syringe having a convenient shape.

In order to achieve the above object, an injection type injector according to a first aspect of the present invention includes a jet injection port provided at a tip of the syringe, a nozzle having a cylinder communicating with the jet injection port, and an inside of the cylinder. In the injection type syringe comprising a piston movable in the front-rear direction, and the chemical liquid fed into the space in the cylinder generated by the retreat of the piston is ejected from the jet injection port by the advance of the piston. Is disposed around the cylinder for storing a chemical solution, and is provided between the chemical solution storage chamber and the cylinder, and supplies the chemical solution in the chemical solution storage chamber to a space in the cylinder. A chemical solution supply passage for preventing the chemical solution in the inside from flowing back into the chemical solution storage chamber and supplying the chemical solution to the space in the cylinder A nozzle having an air intake passage for feeding air from outside into the chemical storage chamber to be pressure and removably attached to the distal end of the syringe.
According to a second aspect of the present invention, the injection syringe according to claim 1 is provided with a chemical liquid supply port for supplying a chemical liquid from the outside to the chemical liquid storage chamber.
A third aspect of the present invention provides the injection type syringe according to claims 1 and 2, wherein a convex lens portion for enlarging and seeing through the inside of the nozzle is provided in the peripheral portion of the nozzle.

The invention further provided by the present invention comprises a jet injection port provided at a tip of a syringe, a nozzle including a cylinder communicating with the jet injection port, and a piston movable back and forth in the cylinder, In the injection type syringe in which the chemical liquid fed into the space in the cylinder generated by the retreat of the piston is ejected from the jet injection port by the advance of the piston, the nozzle is disposed around the cylinder. A chemical solution storage chamber for storing a chemical solution, and a chemical solution that is disposed between the chemical solution storage chamber and the cylinder and supplies the chemical solution in the chemical solution storage chamber to a space in the cylinder, and the chemical solution in the cylinder flows backward into the chemical solution storage chamber. And a chemical solution supply channel for preventing the chemical solution from being generated, and the chemical solution is generated in the chemical solution storage chamber by supplying the chemical solution to the space in the cylinder. That the nozzle formed by providing a slidable rubber stopper in a direction in which the space portion is eliminated in the chemical storage chamber, and removably attached to the distal end of the syringe.
According to a fifth aspect of the present invention, there is provided a magnet and a jet injection port of a nozzle that open a check valve provided in the chemical liquid supply channel connecting the cylinder and the chemical liquid storage chamber by covering the nozzle. And a cap provided with a sealing member for closing.

In the present invention, since the chemical liquid storage chamber is formed in the nozzle itself, it is a small and repetitive type that is easy to use everyday (it is not necessary to attach a chemical vial or the like each time in order to suck the chemical liquid once) Can be realized, the diameter of the syringe body can be reduced, and handling and carrying become very convenient.
In addition, since the drug solution can be stored in advance in the drug solution storage chamber from the syringe with a needle, or the drug solution in the drug solution vial or cartridge can be stored in the drug solution storage chamber via the jet injection port, the drug solution vial or cartridge is always carried. This eliminates the need to keep track of components and reduces the number of components.
Furthermore, by closing one end of the drug solution storage chamber with a slidable rubber stopper, clogging in the drug solution supply channel due to the mixture of insulin and the drug solution is prevented, and long-term use becomes possible.

  Embodiments of the present invention will be described below with reference to the drawings. 1 is an external view of an injection type syringe according to Example 1, FIG. 2 is a cross-sectional view showing the inside of the injection type injector according to Example 1, FIG. 3A is a side cross-sectional view showing a nozzle 101 and its peripheral part, and FIG. (B) is AA sectional drawing in (a) figure. As shown in FIG. 2, the injection type syringe of the first embodiment has a chemical solution storage chamber 106 for storing a chemical solution in advance, a nozzle 101 for injecting the chemical solution, and a syringe main body 102 for performing operations necessary for injection. The nozzle 101 and the syringe body 102 are detachably coupled by screwing.

  As shown in FIG. 3, the nozzle 101 is a substantially cylindrical body made of a hard synthetic resin such as a transparent polycarbonate resin, and has a jet injection port 104 at its tip, a cylinder 105 communicating with the jet injection port 104, The chemical solution storage chamber 106 for storing the chemical solution in the periphery of the cylinder 105, the chemical solution supply channel 106 a that supplies the chemical solution from the chemical solution storage chamber 106 to the cylinder 105, and the air is taken into the chemical solution storage chamber 106 from the outside. An air intake passage 106b is provided, and a cap 103 is covered except when necessary as described later. The chemical solution supply flow path 106a is provided with a check valve 100 including a resin small ball 106c and a coil spring 106d that operate so that the chemical solution does not flow backward from the cylinder 105 to the chemical solution storage chamber 106, and the air intake flow A check valve 100 comprising a small ball 106e and a coil spring 106f is also provided in the passage 106b. A transparent convex lens portion 107 is formed on a part of the outer periphery of the cylinder 105 in the same manner as the nozzle 101 so that the air vent state in the chemical solution in the cylinder 105 can be observed well.

  As shown in FIG. 2, the syringe body 102 has a cylindrical body 110 made of stainless steel or a hard synthetic resin such as polycarbonate resin, in which both front and rear cylinders 111 and 112 are screwed together. The rear cylinder 112 is reciprocated along the axial direction by rotating the rear cylinder 112 while holding the front cylinder 111. The syringe main body 102 includes a piston moving rod 113 that is disposed so as to be reciprocally movable in the axial direction of the cylindrical body 110. That is, a piston 9 is connected to the rod 113 at the tip, and the piston 9 is configured to move forward and backward in the cylinder 105 as the rod 113 reciprocates. The piston 9 includes seal portions 9 a and 9 b in the middle, and can move forward and backward while maintaining a state of being airtightly fitted to the cylinder 105. Further, the rod 113 is integrally provided with a flange 14 at a length of about 1/3 of the entire length from the tip, and a plurality of latch balls 21 to be described later fall on the peripheral surface near the rear end. A latch hole 13a is formed by digging.

  On the other hand, on the inner side of the rear cylinder 112, there is a thick portion 15a, a thin portion 15b extending long from the thick portion 15a to the front side in the axial direction, and a little rearward from the thick portion 15a in the axial direction. A fixed small cylinder 15 consisting of an extending thin portion 15c is coaxially and integrally attached. The rear end side of the rod 113 is coaxially inserted into the hole of the fixed small cylinder 15. Further, a strong compression spring 17 passed through the rod 113 is interposed between the front side surface of the thick portion 15a of the fixed small cylinder 15 and the flange 14, and the rod 113 is moved forward by the compression spring 17. It has a constantly energized configuration. However, the rod 113 is configured not to advance further when the flange 14 hits the stopper plate 18 provided inside the front cylinder 111.

  Further, on the inner side of the rear cylinder 112, the slide cylinder 16 is inserted and disposed on the rear side of the fixed cylinder 15 so as to be movable in the axial direction. The rear end surface portion 16a of the slide tube 16 serves as a latch release button. A movable small piece 19 is fitted to the rear end of the fixed small cylinder 15 so as to be movable in the axial direction, and a compression spring 20 is interposed between the movable small piece 19 and the inner surface side of the slide small cylinder 16. Has been. The slide tube 16 is constantly biased in the backward direction by the compression spring 20. However, even if the slide tube 16 is urged in the backward direction, the slide tube 16 is not retracted beyond the position where it comes into contact with the stopper piece 12.

  Further, a small hole 15d penetrating in the circumferential direction is formed in the rear end paragraph of the fixed small cylinder 15. A latch ball 21 is fitted in each small hole 15d, and the inner surface of the front end portion of the slide tube 16 advances beyond the latch ball 21. Then, the slide small cylinder 16 is locked with the latch ball 21 by the urging force of the compression spring 20 so that the slide small cylinder 16 does not move backward. That is, in the state of FIG. 2, the slide small cylinder 16 and the movable small piece 19 are also integrated with the rear cylinder 112 due to the locking of the slide small cylinder 16 and the latch ball 21. Then, if the rear cylinder 112 is screwed into the front cylinder 111, the components up to the fixed small cylinder 15, the slide small cylinder 16, the movable small piece 19, the compression spring 20 and the latch ball 21 are brought together with the rear cylinder 112. It is structured to move forward.

  On the other hand, a dial scale 112a indicating the amount of the chemical solution sucked along the circumference is printed or engraved on the outer peripheral surface near the front of the rear cylinder 112. As shown in FIG. 5, a scale window 111a for reading the scale is opened. Accordingly, when the rear cylinder 112 is rotated counterclockwise while the front cylinder 111 is fixed, the rear cylinder 112 is relatively retracted and the scale value displayed on the scale window 111a is increased. The space part formed between the cylinder 105 and the piston 9 shown in FIG.

  Next, the configuration of the first embodiment will be described in more detail in accordance with the flow of a series of operations when executing needleless injection with the above-described injection type syringe. In the following description, it is assumed that the drug solution is already stored in the drug solution storage chamber 106 and that the injection syringe is in the state shown in FIG.

  (1) When performing needleless injection, with the cap 103 removed, the rear cylinder 112 is first rotated with the other hand while the front cylinder 111 is held with one hand, and the rear cylinder 112 is moved to the front cylinder 111. Screw in and move forward. Then, the slide tube 16 moves forward while being pulled by the fixed tube 15 while being locked to the latch ball 21, and as shown in FIG. 4, the latch ball 21 eventually falls halfway into the latch hole 13a. Since the slide tube 16 urged in the backward direction by the compression spring 20 moves backward slightly and continues to hold the latch ball 21 from the side, the latch ball 21 does not jump out of the small hole 15d, and the rod 113 is maintained in a state of being latched to the fixed small cylinder 15 by the latch ball 21.

  In the state where the nozzle 101 and the syringe body 102 are coupled and the rod 113 is not locked to the fixed small cylinder 15, the tip of the piston 9 is positioned at the front end of the cylinder 105 as shown in FIG. In the cylinder 105, no space is formed. Further, just by locking the rod 113 to the fixed small cylinder 15 with the latch ball 21 as described above, the tip of the piston 9 is also positioned at the front end of the cylinder 105, and a space portion is generated in the cylinder 105. Not.

  (2) Next, with the cap 103 placed on the nozzle 101, the rear cylinder 112 is reversely rotated with the other hand while holding the front cylinder 111 with one hand, as shown in FIG. The rod 113 locked to the cylinder 15 is also pulled, and the rear cylinder 112 is moved backward from the front cylinder 111. Then, the rod 113 together with the rear cylinder 112 also moves backward together with the compression spring 17, so that the piston 9 connected to the rod 113 also moves backward, and the tip of the piston 9 falls behind the front end of the cylinder 105. A negative pressure space is formed on the front side of the. As a result, the small ball 106c constituting the check valve 100 shown in FIG. 3 moves away from the chemical solution storage chamber 106 against the coil spring 106d, and the chemical solution flows into the space. At the same time, the inside of the chemical solution storage chamber 106 is also in a negative pressure state due to the reduction of the chemical solution, and the small ball 106e moves away from the inner wall of the chemical solution storage chamber 106 against the coil spring 106f, and air flows from the outside. At this time, the rear cylinder 112 is moved backward so that the volume of the space generated in the cylinder 105 is larger than the amount of the medicinal solution to be injected.

  (3) Subsequently, the cap 103 is removed, and the rear cylinder 112 is screwed into the front cylinder 111 until the chemical liquid slightly leaks out from the jet injection port 104 with the jet injection port 104 facing upward. Then, as shown in FIG. 6, the space in the cylinder 105 is completely filled with the chemical M, that is, no bubbles are present in the chemical M. The safety can be sufficiently confirmed by observing from the convex lens unit 107 that bubbles in the chemical M are completely eliminated.

  (4) The jet injection port 104 is pressed against the injection location, and the rear end surface portion 16a of the slide small cylinder 16 serving as a latch release button shown in FIG. 5 is pressed. Then, the compression spring 20 is pressed and contracted, and the slide small cylinder 16 moves forward, and the latch ball 21 jumps out of the latch hole 13a, so that the rod 113 and the fixed small cylinder 15 are unlocked. When the locking of the rod 113 and the fixed small cylinder 15 is released, the rod 113 is instantaneously advanced to the point where the flange 14 contacts the stopper plate 18 by the urging force of the strong compression spring 17. As the rod 113 rapidly advances, the piston 9 also advances rapidly, so that the chemical solution in the space of the cylinder 105 is pressurized and ejected from the jet injection port 104 and injected subcutaneously. Note that, at the stage where the injection is completed, the injection type syringe returns to the initial state shown in FIG. In this way, the first injection is completed. When the next needle-free injection is performed, the above (1) to (4) are repeated.

  As described above, the injection type syringe of Example 1 is provided with the chemical solution storage chamber 106 in which the chemical solution is stored in advance, that is, the disposable type nozzle 101 is used. There is no need to suck the drug solution from the body drug vial into the syringe. Further, there is no trouble that only one of the injection type syringe and the drug solution vial is carried and the other is forgotten, and the injection cannot be performed at a necessary time.

  FIG. 7 shows a side cross-sectional view (a) and a BB cross-sectional view (b) of the tip portion of the nozzle 101A and the front cylinder 111 used in the injection type syringe according to the second embodiment. This injection type syringe has a chemical solution replenishing port 106g for replenishing the chemical solution storage chamber 106 from the outside and a nozzle 101A provided with a lid or rubber plug 106h for closing the chemical solution replenishing port 106g except when refilling. I use it. When replenishing the drug solution, suck the drug solution in the cartridge or drug solution vial into a syringe with a needle, remove the lid if the lid is attached, and inject the drug solution, and if a rubber stopper is attached, insert the needle of the syringe with a needle directly. Then inject chemicals. As a result, the nozzle 101A can be used continuously, and by replenishing the necessary amount of the chemical solution in advance, it is possible to eliminate the need to carry the cartridge or the chemical solution vial and to eliminate the worry of forgetting to carry it. .

  FIG. 8 shows a side cross-sectional view (a) of a nozzle 101B, which is a modification of the nozzle 101A of the second embodiment, and its AA cross-sectional view (b). The nozzle 101B is provided with a chemical liquid storage chamber 106A having an open front end inside the periphery of the cylinder 105, and a ring-shaped rubber stopper 200 is inserted into the chemical liquid storage chamber 106A so as to be movable in the axial direction. When the rubber plug 200 is pushed into the drug solution storage chamber 106A and the needle tip of the syringe with needle is inserted into the rubber plug 200 and the drug solution is supplied to the drug solution storage chamber 106A, the rubber plug 200 increases the amount of the stored drug solution. Along with this, the liquid gradually moves in the distal direction to a position where it hits a stopper (not shown) provided at the opening edge of the liquid chemical storage chamber 106A, and the liquid chemical is filled in the liquid chemical storage chamber 106A. In this state, the piston 9 is once applied to the tip of the cylinder 105, the cap 103 is put on the nozzle 101B, and the piston 9 is pulled back. It is gradually sent to the department. As a result, the inside of the rubber plug 200 has a negative pressure, and the rubber plug 200 is moved by receiving a force in the rear side direction (arrow direction), and the space in the chemical solution storage chamber 106A is prevented while preventing the entry of air from the outside. Part is buried.

  A series of operation methods in the case of performing needleless injection using an injection type syringe coupled with the nozzle 101B and the operation of the injection type injector associated therewith are the same as in the case of the injection type injector described in the first embodiment. .

  9A and 9B are cross-sectional views of the nozzle 101C of the injection syringe according to the third embodiment. FIG. 9A is a cross-sectional view showing a state before storing the chemical liquid, and FIG. 9B is a state in which the chemical liquid is taken into the cylinder 105. (C) is sectional drawing which shows the state filled with the chemical | medical solution. As shown in FIG. 9 (a), the nozzle 101C locks a cap 103A in which a magnet 103a is embedded in a nozzle 101B (see FIG. 8) of the injection type syringe according to the second embodiment with a hinge 106i, and a cap 103A. The check valve 100 in the chemical liquid supply flow path 106a is opened and closed in response to the opening and closing.

  In the initial state of the injection type syringe, that is, in a state where no chemical solution is stored in the chemical solution storage chamber 106B, the rubber plug 200 is in contact with the back wall of the chemical solution storage chamber 106B as shown in FIG. ing. In order to inject the chemical liquid into the chemical liquid storage chamber 106B, the cap 103A is opened as shown in FIG. 9B, and the adapter 202 is fitted to the nozzle 101C with the piston 9 applied to the tip of the cylinder 105. Then, with the chemical vial 201 pushed into the needle of the adapter 202, the piston 9 is moved backward to take the chemical into the cylinder 105. Next, as shown in FIG. 9C, the adapter 202 and the chemical vial 201 are removed, and the cap 103A is closed. Since the magnet 103a is attached to the cap 103A, the small ball 106c using the magnetic material of the check valve 100 is attracted by the magnet 103a, and this attraction force overcomes the spring force of the coil spring 106d, and the check valve 100 100 opens. When the piston 9 is pushed in this state, the chemical liquid in the cylinder 105 passes through the check valve 100 and is stored in the chemical liquid storage chamber 106B. By repeating the series of operations shown in FIGS. 9A, 9B, and 9C, an amount that is many times larger than the amount of the chemical liquid that can be taken into the cylinder 105 can be stored in the chemical liquid storage chamber 106B. Further, by changing the shape of the adapter 202, the chemical solution can be stored from the cartridge in the chemical solution storage chamber 106B by the same operation.

The present invention is not limited to the form of the embodiment. For example, the small ball 106c used for the check valve 100 in the nozzle 101 of the first embodiment is a steel ball, and a magnet is embedded in the vicinity thereof, thereby attracting the magnetic force. It is also possible to open and close the flow path using. A plurality of chemical solution storage chambers may be provided to store different chemical solutions.
Further, in the nozzle 101C of the third embodiment, the arrangement of the check valve 100 is changed to increase the magnetic force by making the distance between the 103a and the small ball 106c closer, and the cap 103A is removed from the nozzle 101C so that the cap 103A does not get in the way at the time of injection. It is also possible to make it removable.

  INDUSTRIAL APPLICABILITY The present invention is used for a jet injector that performs insulin injection, gene therapy drug injection, and vaccine injection for diabetes.

It is a top view which shows the external appearance of the injection type syringe of an Example. It is side surface sectional drawing which shows the structure inside the injection type syringe of an Example. It is side surface sectional drawing (a) and AA sectional drawing (b) of the nozzle concerning an Example. It is sectional drawing which shows the latch condition of the rod in the syringe of an Example. It is sectional drawing which shows the retreating state of the rod and piston in the injection device of an Example. It is sectional drawing which shows the chemical | medical solution filling condition in the cylinder in the injection device of an Example. It is side surface sectional drawing (a) and BB sectional drawing of the other nozzle which concerns on an Example. It is side surface sectional drawing (a) and AA sectional drawing of the other nozzle which concerns on an Example. It is side surface sectional drawing of the other nozzle which concerns on an Example, (a) is the time of an initial state, (b) is the time of chemical | medical solution vial connection, (c) shows the state at the time of chemical | medical solution storage to a chemical | medical solution storage chamber. It is sectional drawing of the conventional injection type syringe.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Injection component 3 Cartridge 5,105 Cylinder 6 Cartridge accommodation long hole 9 Piston 9a, 9b Seal part 12 Stopper piece 13a Latch hole 14 Flange 15 Fixed small cylinder 15a Thick part 15b, 15c Thin part 15d Small hole 16 Slide small cylinder 16a Rear end surface portion 17 Compression spring 18 Stopper plate 19 Movable small piece 20 Compression spring 21 Latch ball 100 Check valve 101, 101A, 101B, 101C Nozzle 102 Syringe body 103, 103A Cap 103a Magnet 104 Jet injection port 106, 106A, 106B Chemical liquid storage chamber 106a Chemical liquid supply flow path 106b Air intake flow path 106c, 106e Small ball 106d, 106f Coil spring 106g Chemical liquid replenishment port 106h Lid or rubber stopper 106i Hinge 107 Convex Lens portion 110 cylinder 111 front cylinder 111a scale window 112 rear cylinder 112a dial graduations 113 rod 200 rubber stopper 201 chemical vial 202 Adapter M chemical

Claims (5)

A jet injection port provided at the tip of a syringe, a nozzle having a cylinder communicating with the jet injection port, and a piston movable back and forth within the cylinder. In the injection type syringe in which the chemical solution fed into the space portion is ejected from the jet injection port by the advance of the piston, the nozzle is disposed around the cylinder and stores a chemical solution storage chamber, A chemical solution supply channel that is disposed between the chemical solution storage chamber and the cylinder and supplies the chemical solution in the chemical solution storage chamber to the space in the cylinder and prevents the chemical solution in the cylinder from flowing back into the chemical solution storage chamber. And air intake for sending air from outside into the chemical solution storage chamber that becomes negative pressure when the chemical solution is supplied to the space in the cylinder. Injection syringe, characterized in that a nozzle having a road and removably attached to the distal end of the syringe. The injection type syringe according to claim 1, wherein a chemical liquid supply port for supplying a chemical liquid from outside is provided in the chemical liquid storage chamber. The injection type syringe according to claim 1 or 2, wherein a convex lens part for enlarging and seeing the inside of the nozzle is provided in a peripheral part of the nozzle. A jet injection port provided at the tip of a syringe, a nozzle having a cylinder communicating with the jet injection port, and a piston movable back and forth within the cylinder. In the injection type syringe in which the chemical solution fed into the space portion is ejected from the jet injection port by the advance of the piston, the nozzle is disposed around the cylinder and stores a chemical solution storage chamber, A chemical solution supply channel that is disposed between the chemical solution storage chamber and the cylinder and supplies the chemical solution in the chemical solution storage chamber to the space in the cylinder and prevents the chemical solution in the cylinder from flowing back into the chemical solution storage chamber. And sliding in a direction in which there is no space generated in the chemical storage chamber by supplying the chemical to the space in the cylinder. A nozzle formed by providing the ability rubber stopper into the chemical storage chamber, injection syringe, characterized in that the removably attached to the distal end of the syringe. By covering the nozzle, a magnet that opens the check valve provided in the chemical solution supply channel that connects the cylinder and the chemical solution storage chamber and a sealing member that closes the jet injection port of the nozzle are provided. The injection syringe according to claim 4, further comprising a cap.

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