JP2005200390A - Endurance promoter and anti-fatigue agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine and a functional food that are effective for endurance promotion and anti-fatigue action. <P>SOLUTION: The subject endurance promoter and the subject anti-fatigue agent contain each Kinsenren (Anoectochilus formosanum Hay.), as active ingredient, in the form of raw plant, dried plant, powder obtained by crushing after dried, or an extract obtained by extraction with hot water or an organic solvent. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a pharmaceutical, a nutritional functional food, or a health food for the purpose of enhancing endurance and anti-fatigue action in humans and animals.

  Now that health consciousness is increasing, there is a growing awareness of the relationship between sports and nutrition / physiology. Under such circumstances, sports foods are used in various situations such as energy supply, fatigue recovery, instantaneous power and endurance enhancement, and body building. Among them, endurance enhancers and anti-fatigue agents are often used not only to improve athletes' performance, but also to maintain endurance when ordinary people work, and to lead a lively life. ing. Many of these endurance enhancers and anti-fatigue agents are made of vitamins and herbal medicines, and have been effective since ancient times without scientific evidence. They contain caffeine and ethyl alcohol, and are excited and insomnia. In many cases, there are some things that are not really aimed at health. Under such circumstances, endurance enhancers and anti-fatigue agents have been found to be clearly effective and have a scientific basis. The same applies to animals. From animals for racing such as racehorses to animals bred in facilities such as livestock, zoos, and animals such as pets, those with increased endurance and anti-fatigue are required. ing.

  The gold line lotus is a perennial medicinal plant of Orchidaceae, which is called Yakuo in Taiwan. It is said to be effective for high blood pressure, antipyretic, poor growth of children, lung disease, sore throat, diabetes, liver disease, kidney disease, and the like (Kan, WS 1979. National Research Institute of Medicine). However, there is no report that gold wire lotus is effective for endurance enhancement and anti-fatigue action.

  The object is to provide pharmaceuticals, nutritionally functional foods, or health foods having endurance enhancing action and anti-fatigue action for humans and animals.

  As a result of intensive studies to solve the above problems, it was found that the gold wire lotus has a remarkable endurance enhancement and anti-fatigue effect. That is, the present invention provides pharmaceuticals, nutritional functional foods, or health foods with endurance enhancement and anti-fatigue action, which use gold wire lotus as an active ingredient, for humans and animals.

  It has been clarified that administration of gold wire lotus has the effect of enhancing endurance and anti-fatigue. Therefore, according to the present invention, it is possible to provide a pharmaceutical, a nutritionally functional food, or a health food having an endurance enhancement and an anti-fatigue action using gold wire lotus as an active ingredient.

  The according to the present invention "gold lotus" refers Anoectochilus formosanus being a gold lotus and Kin'enshu, Anoectochilus reinwardii, Anoectochilus koshunensis, Anoectochilus roxburghii Lindly, Anoectochilus Blume Odontchilus inabai Hayata, etc. Odontchilus bisaccatus Hayata.

  The gold wire lotus according to the present invention can be used as it is, and can also be used as a dried or pulverized powder after drying. It can also be used as an extract extracted with an organic solvent such as hot water extraction, ethanol, or ethyl acetate.

  “Endurance” according to the present invention refers to the ability to continuously perform a certain exercise state. “Fatigue” refers to a phenomenon in which the function of a living body is reduced as a result of exerting a function. Examples include, but are not limited to, “I can continue swimming for a long time”, “I don't get tired even if I work for a long time”, “I don't get tired in my daily life”, and the like.

  In order to produce the endurance enhancer and anti-fatigue agent according to the present invention, the gold wire lotus powder or extract produced by the above method can be used in combination with a known non-toxic pharmaceutical carrier according to a conventional method. What is necessary is just to formulate. The endurance enhancer and anti-fatigue agent according to the present invention can be administered in various dosage forms, for example, as oral administration agents, solid agents such as tablets, granules, powders, capsules, soft capsules, Solutions, suspensions, emulsions and other solutions, lyophilized preparations and the like are included. Parenteral administration agents include injections, suppositories, sprays, transdermal absorption agents, etc., and these preparations Can be adjusted by conventional means on formulations. Examples of the non-toxic pharmaceutical carrier include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, albumin, water And physiological saline. If necessary, conventional additives such as stabilizers, lubricants, wetting agents, emulsifiers, binders and the like can be appropriately added. In the endurance enhancer and anti-fatigue agent according to the present invention, the dose of gold wire lotus powder or extract is appropriately selected and determined according to the patient's age, weight, symptoms, degree of disease, administration schedule, formulation form, etc. However, for example, the daily dose is about 0.01 to 10 g / kg body weight, and the dose may be divided into several times a day. A similar formulation may be used for animals. It is appropriately selected and determined according to the age, body weight, symptoms, degree of disease, administration schedule, formulation form, etc. of the animal. For example, it is about 0.01 to 10 g / kg body weight per day and divided into several times a day. May be administered.

  In addition, the gold wire lotus according to the present invention is considered to be highly safe because it has abundant eating experience, and can be taken as a functional food for the purpose of enhancing endurance and anti-fatigue action. The functional food characterized by containing the gold wire lotus (raw, dry powder or extract) according to the present invention can be positioned as a food for specific insurance, a nutritional functional food, or a health food. As a functional food, for example, after adding an appropriate auxiliary agent to gold wire lotus (raw, dry powder or extract), using a conventional means, a form suitable for food, for example, granular, Those formed into granules, tablets, capsules, pastes and the like can be used. This functional food may be used as it is, or added to various foods (eg, ham, sausage, kamaboko, chikuwa, bread, butter, powdered milk, confectionery, etc.), water, alcoholic beverages, fruit juice It may be used by adding to drinks such as milk and soft drinks. The intake amount of the gold wire lotus (raw, dry powder or extract) of the present invention in the form of such food is appropriately selected and determined according to the age, weight, symptoms, intake schedule, formulation form, etc. of the subject. For example, it is set to about 001 to 10 g / kg body weight per day. Similarly in animals, after adding a suitable auxiliary agent to gold wire lotus (raw, dry powder or extract), it is used in a conventional manner and is in an edible form, for example, granular, granular, tablet , Capsules, pastes and the like can be used. Moreover, you may add and use for feed and pet food, or may add to drinking water, such as water. The intake amount of the gold wire lotus (raw, dry powder or extract) of the present invention in the form of such food is appropriately selected and determined according to the age, weight, symptoms, intake schedule, formulation form, etc. of the animal. For example, about 0.01 to 10 g / kg body weight per day.

  Examples are given below to describe the present invention in more detail, but the present invention is not limited by these.

Example Effect of Enhancing Endurance and Anti-Fatigue Action of Gold Wire Lotus After putting ethanol in a ratio of 1: 2 into a raw wire wire lotus and grinding, it was extracted for 24 hours and filtered under reduced pressure. The obtained filtrate was concentrated under reduced pressure and then freeze-dried to obtain a dark red powder. Four-week-old male ddY mice were used, and after preliminary breeding for 5 days, 10 mice were divided into 2 groups. The group composition was the control group (water administration group) and the gold wire lotus extract 1000 mg / kg extracted by the above method as the administration group, and oral administration was performed for 5 days a week. From the first week after the administration, a weight of 10% of the body weight was added to the mouse and forced swimming was performed, and the time until the head was completely tired and submerged in water for 5 seconds was measured. The results are shown in Table 1. Average value (sec.) ± standard error was shown. *: P <0.05 vs administration group, tested by Student's t-test.

  From this result, the remarkable effect of extending swimming time was recognized in the gold wire lotus administration group.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide humans and animals with pharmaceuticals, nutritional functional foods, or health foods that have endurance enhancing action and anti-fatigue action using gold wire lotus as an active ingredient.

Claims (1)

  Endurance enhancer and anti-fatigue agent containing gold wire lotus as an active ingredient