JP2005034639A - Ocular perfusion storing body - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an ocular perfusion storing body which is convenient when it is discarded, is easy to store, and is excellent in two-liquid mixing workability when it is used. <P>SOLUTION: An oxy-glutathione containing solution and a bicarbonate solution are filled in a plastic soft bottle X of self-sustainable and engaged mixture integral. Furthermore concretely speaking, the soft bottle X has a first room which is insulated and formed in water tight by a partition and a second room. The oxy-glutathione containing solution is enclosed in the first room. The bicarbonate solution is enclosed in the second room. Mixing mechanism which can mix the oxy-glutathione containing solution and the bicarbonate solution in communication with the first room and the second room when they are used, is prepared. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a container for an eye perfusate.

  Ocular perfusate containing oxyglutathione as an active ingredient is used in ophthalmic operations such as cataract surgery, vitreous surgery, and glaucoma surgery. Oxyglutathione is stable in the acidic region, but unstable in the neutral region. On the other hand, bicarbonate is stable in the basic region. Therefore, in order to keep both components stable, the oxyglutathione solution and the bicarbonate solution are separately stored in a stable pH region, and stored and used in a form in which both solutions are mixed at the time of use. Since the bicarbonate solution releases carbon dioxide during storage, a glass container having a gas barrier property is used to prevent this.

  Therefore, the conventional eye perfusate has been sold in a two-bottle form in which a glass container contains an oxyglutathione solution and a bicarbonate solution, respectively (BSS Plus, Santen Pharmaceutical Co., Ltd.).

  However, glass containers are heavy and lack the convenience of disposal. In addition, the two-bottle type in which the oxyglutathione solution and the bicarbonate solution are housed in separate glass bottles has a gas barrier property, but it is necessary to use a transfer needle to mix the two solutions, and the mixing work becomes complicated.

Therefore, it has been proposed to use a plastic multi-chamber bag (see, for example, Patent Documents 1 to 3). This is because the oxyglutathione solution and bicarbonate solution are housed in each chamber of a gas permeable plastic multi-chamber bag, and the bag is further wrapped with a gas-impermeable packaging material to prevent the release of carbon dioxide gas. It is.
Such a multi-chamber bag is capable of mixing both solutions without using a transfer needle, makes the mixing operation relatively easy, and is highly convenient for disposal.
Japanese Patent No. 3116118 JP 2000-281147 A JP 2000-288066 A

  In such a multi-chamber bag, in order to mix the oxyglutathione solution and the bicarbonate solution, it is necessary to place the bag on a table and press it so that the isolation seal part is peeled off so that the two chambers communicate with each other. However, a large work space is required to place and press on the table during mixing. In addition, since the glass container is self-supporting, it is convenient for storage. On the other hand, the multi-chamber bag is not easy to be self-supporting and needs to be stored in a laid state, so that a wide storage space is required.

  An object of the present invention is to solve the above-mentioned problems and to provide an eye perfusate container that is highly convenient for disposal, easy to store, and excellent in two-liquid mixing workability during use.

  The first characteristic configuration of the ocular perfusate container according to the present invention is that an oxyglutathione-containing solution and a bicarbonate solution are filled into a plastic soft bottle that is self-mixing and can be used independently.

  According to a second characteristic configuration of the ocular perfusate container of the present invention, in the above-described characteristic configuration, the soft bottle includes a first chamber and a second chamber formed in a watertight manner by a partition wall, and the first chamber has an oxy A glutathione-containing solution is sealed, a bicarbonate solution is sealed in the second chamber, and the first chamber and the second chamber are communicated with each other during use so that the oxyglutathione-containing solution and the bicarbonate solution can be mixed. A mixing mechanism is preferably provided.

  According to a third characteristic configuration of the ocular perfusate container of the present invention, in the above-described characteristic configuration, it is preferable that a packaging material made of gas-impermeable plastic for packaging the soft bottle is provided.

  The fourth characteristic configuration of the ocular perfusate container of the present invention is preferably a bottomed type in which the packaging material can stand on its own in the above-described characteristic configuration.

  According to a fifth characteristic configuration of the eye perfusate container of the present invention, in the above characteristic configuration, it is preferable that a space portion between the soft bottle and the packaging material is filled with air or nitrogen gas.

  According to a sixth characteristic configuration of the ocular perfusate container of the present invention, in the above-described characteristic configuration, it is preferable that an oxygen detection agent is sealed in a space portion between the soft bottle and the packaging material.

  According to a seventh characteristic configuration of the eye perfusate container of the present invention, in the above-described characteristic configuration, it is preferable that an oxygen scavenger is further sealed in the space portion.

  According to an eighth characteristic configuration of the ocular perfusate container of the present invention, in the above-described characteristic configuration, the oxygen scavenger is preferably a non-carbon dioxide generating type.

  According to a ninth characteristic configuration of the eye perfusate container of the present invention, in the above-described characteristic configuration, it is preferable that a packaging material opening portion is provided at a neck height position of the soft bottle in the packaging material.

  According to a tenth characteristic configuration of the eye perfusate container of the present invention, in the above-described characteristic configuration, a packaging material opening portion that opens the packaging material in a shape that can be wound and held around the body portion of the soft bottle is provided in the packaging material. It is preferable that a plurality of packaging materials that have been opened from the packaging material opening portion are arranged so as to be formed on a cover member capable of imparting pressure resistance to the soft bottle.

  As a result of diligent research to solve the convenience of disposal of the ocular perfusate container, mixing operability, and the like, the present inventors have found that an oxyglutathione-containing solution and a bicarbonate solution can be self-supporting and can be used as a self-mixing plastic soft bottle. It was found that these problems can be solved if it is accommodated in the.

Since the oxyglutathione-containing solution and the bicarbonate solution are accommodated in the soft bottle, the convenience at the time of disposal can be increased as in the conventional multi-chamber bag. By making it possible to mix at the time of use, the two-liquid mixing workability at the time of use can be enhanced. In addition, when using a soft bottle, the two-part mixing workability is higher than when using a soft bottle, because it is possible to accurately apply force to the action site when communicating the storage parts of both solutions during mixing at the time of use. In addition, the mixing operator can perform the two-liquid mixing operation without requiring a large work space. In addition, by configuring the soft bottle so as to be independent, the soft bottle can be stored independently, and a large amount of ocular perfusate container can be stored with less management space.
Therefore, in order to keep both components stable, the oxyglutathione solution and the bicarbonate solution can be stored and used separately in a stable pH region, and both solutions can be mixed at the time of use.

  In addition, as described in the second characteristic configuration, in performing the previous two-component mixing, a first chamber and a second chamber formed in a watertight manner by a partition wall are provided, and an oxyglutathione-containing solution and a bicarbonate solution are provided. If they are housed individually, there is no risk of mixing them in the preserved state. In addition, since both chambers are separated by a partition wall, the mixing mechanism allows the first chamber and the second chamber to communicate with each other at the time of use, so that the watertightness of the partition wall is lost. Two liquids can be mixed.

  In addition, as the soft bottle, in order to prevent carbon dioxide leakage from the contained bicarbonate solution part and prevent oxygen gas inflow from the outside, non-permeable ones are suitable, but having appropriate flexibility, In consideration of restrictions such as the fact that the components do not elute in the solution to be contained, at present, soft bottle materials having such physical properties are not well known. Therefore, as described in the third characteristic configuration, if the soft bottle is packaged by providing a packaging material made of gas-impermeable plastic, the carbon dioxide gas from the bicarbonate solution portion is moved out of the soft bottle. Even if it permeates, the gas is stored in a space portion between the packaging material and the soft bottle, and when the gas concentration in the soft bottle and the gas concentration in the space portion reach equilibrium, the gas Since permeation can be suppressed, deterioration of the bicarbonate solution can be suppressed. On the other hand, the gas that can permeate into the soft bottle from the outside is also limited to the gas in the space portion, so that the deterioration of the oxyglutathione-containing solution or bicarbonate solution can be suppressed. it can.

  Further, as described in the fourth feature configuration, if the packaging material can be self-supporting, the packaging material does not hinder the self-supporting of the soft bottle, and further, the self-supporting property of the soft bottle is increased. It can be stored more stably. Therefore, the soft bottle can be stored independently, and a large amount of ocular perfusate container can be stored with less management space.

  Here, as described in the fifth characteristic configuration, if air or nitrogen gas is filled in a space portion between the soft bottle and the packaging material, the air or nitrogen gas pressure causes heavy load. Carbon dioxide leakage from the carbonic acid solution portion can be minimized.

  In addition, as described in the sixth feature configuration, whether or not oxygen exists in the space portion when an oxygen detection agent is sealed in the space portion between the soft bottle and the packaging material. Can be easily discriminated visually, so that the flow of oxygen into the space due to the breakage of the packaging material, pinholes, etc. can be determined at an early stage. It is possible to reduce the possibility of using a deteriorated oxyglutathione-containing solution by mistake.

  Further, as described in the seventh characteristic configuration, the oxygen concentration in the space portion can be lowered by sealing the oxygen scavenger in the space portion. Thereby, the sensitivity of the oxygen detection agent is improved, and the accuracy of pinhole detection by the oxygen detection agent can be increased.

  Furthermore, as described in the eighth characteristic configuration, when the oxygen scavenger is a non-carbon dioxide generating type, the carbon dioxide concentration in the space portion is kept stable.

  Further, as described in the ninth feature configuration, when the packaging material is provided with a packaging material opening portion, the packaging material can be easily opened at a predetermined position. If this packaging material opening part is provided at the neck height position of the soft bottle, the soft bottle can be easily taken out and opened, and the oxygen detection agent and oxygen scavenger provided inside can be easily taken out. Can be discarded.

  Further, as described in the tenth characteristic configuration, the packaging material is provided with a plurality of packaging material opening portions for opening the packaging material in a shape that can be wound and held around the body portion of the soft bottle, and the packaging material When the packaging material that has been opened from the material opening portion is disposed so as to be formed on a cover member that can impart pressure resistance to the soft bottle, the soft bottle can be used even when pressure is applied to the inside of the soft bottle. It is possible for the packaging material to suppress expansion as the internal pressure increases. Therefore, pressure resistance can be imparted to the soft bottle. Therefore, if a packaging opening portion for further processing the packaging material into a cover member is provided, the packaging material can be easily processed, and the cover member can be used effectively to gas the soft bottle. When the ophthalmic perfusate mixed and dispensed inside the soft bottle is applied to a pressurization operation or the like by press-fitting, the pressure resistance can be improved and used more safely.

  The present invention is an ocular perfusate container, and the ocular perfusate is composed of an oxyglutathione solution as an active ingredient and a bicarbonate solution as a diluent. The oxyglutathione solution and the bicarbonate solution are stored in a mixed plastic plastic bottle at the time of use, and both solutions are mixed into an eye perfusate at the time of use.

  The oxyglutathione concentration in the oxyglutathione solution is preferably 0.1 to 1.0% (W / V). In addition to oxyglutathione, an isotonic agent such as sodium chloride, calcium chloride, magnesium chloride, and dextrose, and a pH adjuster such as sodium hydroxide and hydrochloric acid can be added to the oxyglutathione solution. The pH of the oxyglutathione solution is adjusted in the acidic region, preferably between 3.0 and 6.0.

  The diluent may contain sodium hydrogen carbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate and the like that generate bicarbonate ions, and preferably contains the sodium hydrogen carbonate. The concentration of sodium bicarbonate in the diluted solution is preferably 0.1 to 0.5% (W / V). To the diluting solution, an isotonic agent such as sodium chloride, potassium chloride and magnesium chloride, a pH buffer such as sodium hydrogen phosphate and sodium phosphate, a pH adjusting agent such as sodium hydroxide and hydrochloric acid, and the like can be added. The pH of the diluted solution is adjusted to the basic region, preferably 7.0 to 8.0.

  When used in an integrated plastic soft bottle, the oxyglutathione solution and bicarbonate solution are isolated and stored in a single plastic soft bottle, and in the stored state, the chamber containing the oxyglutathione solution and the bicarbonate solution are stored. This is a plastic soft bottle provided with a mixing mechanism in which the two chambers are communicated with each other and mixed with the oxyglutathione-containing solution and the bicarbonate solution at the time of use.

  As the mixing mechanism, a known method for communicating the two chambers by operations such as rotation and push-in may be used. Specifically, the sealing portion of the communication hole is peeled off by the rotation operation and the two chambers communicate (for example, Japanese Patent No. 3321388, Japanese Patent Application Laid-Open No. 2001-161791, Japanese Patent Application Laid-Open No. 4-327850, Japanese Patent Application Laid-Open No. Hei 4). -36763), in which the sealing member of the communication hole is opened and moved with respect to the communication hole by a rotation operation (for example, Japanese Patent Laid-Open No. 6-225920, Japanese Utility Model Publication No. 51-31252), the relative rotation of the two chambers That change from a closed state to a communication state by the above (for example, JP-A-4-329957 and JP-A-5-3905), and those in which the partition wall film is broken and communicated by pushing operation (for example, Japanese Utility Model Publication No. 51-9510). Gazette). When these mechanisms are used, the two liquids can be mixed by a simple operation such as rotation or pushing of the cap portion without requiring a large space.

  The plastic soft bottle has moderate flexibility and has a bottle shape. The material may be any material usually used for medical purposes, and examples thereof include polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), and PP and PE are particularly preferable. The capacity of the plastic soft bottle is preferably in the range of 5 to 50 mL for the chamber containing the glutathione solution, and 100 to 2000 mL for the chamber containing the bicarbonate solution. It is desirable to provide a port at the top of the plastic soft bottle. Furthermore, it is preferable to install a foldable suspending tool on the outer surface of the bottom so that it can be hung on a hook during perfusion.

  Since the material of these plastic soft bottles is usually gas permeable, in the present invention, it is desirable to wrap the plastic soft bottle with a gas non-permeable plastic packaging material. Gas impermeable plastic packaging materials include PET film, nylon film, linear low density polyethylene (LLDPE) film, polyvinyl alcohol film, saponified ethylene-vinyl alcohol copolymer film, polyvinylidene chloride film, and these There are those in which aluminum oxide (alumina) or the like is vapor-deposited on the surface, or a laminate of these films. From the viewpoint of gas barrier properties, flexibility, etc., the packaging material is preferably a film in which the outermost layer is laminated in the order of alumina-deposited PET-nylon-LLDPE.

  The gas non-permeable plastic packaging material is a plastic soft bottle made by, for example, stacking two films and sealing the outer periphery or by folding one film and sealing the remaining three sides. Can be accommodated. Furthermore, it is desirable to have a shape that is self-supporting with a bottom. As such a shape, a bag in which a packaging material is folded inward in a bowl shape and a gusset is provided at the bottom is generally used (for example, FIG. 6 of Japanese Patent Publication No. 5-88673). Thus, by making it a self-supporting shape, even if a plastic soft bottle is packaged with a packaging material, it can be stored upright.

Further, the use of a self-supporting packaging material has the following advantages.
When the packaging material is a simple bag shape, the container is three-dimensional, whereas the packaging material is flat, so that wrinkles are likely to occur near the container bottom of the packaging material. However, if the packaging material is self-supporting as described above, it is easy to fit the container shape, the packaging material is less likely to wrinkle, and the occurrence of pinholes in the packaging material can be prevented. If a pinhole is generated in the packaging material, carbon dioxide accumulated in the space is released to the outside, and the release of carbon dioxide from the bicarbonate solution is promoted. As a result, the pH of the bicarbonate solution increases, but the solution whose pH has been increased cannot be used as an eye perfusate because it has deteriorated. Since it became difficult for pinholes to enter the packaging material, the storage condition of the eye perfusate was improved, and the quality of the eye perfusate was easily maintained.

  Carbon dioxide gas is gradually released from the bicarbonate solution. To minimize the release of carbon dioxide gas, the volume of the space between the plastic soft bottle and the packaging material should be as small as possible. Is desirable. When packaging a bottle-shaped container with packaging material, the packaging material is more self-supporting with a gusset at the bottom than a simple bag, so that the packaging material fits the container shape and Volume can be reduced. In order to further reduce the volume of the space portion, it is preferable to set the length of the inner periphery of the packaging material so that there is no gap as much as possible between the packaging material and the body of the plastic soft bottle.

  Furthermore, the packaging material can be provided with a notch (packaging material opening part) as a packaging material opening part so as to be cut at the height of the neck of the plastic soft bottle. In this way, the soft bottle can be easily taken out from the packaging material, and pressure resistance can be imparted to the soft bottle in a state where the opened packaging material is wound around and held on the body of the soft bottle. Formed on the cover member. Thereby, the packaging material in the lower part from the neck after cutting the packaging material opening part can be used as a cover for the plastic soft bottle, and the expansion of the soft bottle can be suppressed, so that it can be used for the pressure type surgery. If there is a gap between the packaging material and the barrel of the plastic soft bottle, it is desirable to fix the packaging material from above the packaging material with a rubber band, a cloth belt or the like.

  The ophthalmic perfusate container according to the present invention can be similarly applied to the pressurization operation by removing the packaging material and covering the outside of the plastic soft bottle with a hard mold or the like.

  The space between the packaging material and the plastic soft bottle does not need to be filled with gas, and may remain air. Or you may fill with nitrogen gas.

  In order to detect the occurrence of pinholes in the packaging material, it is preferable to install an oxygen detection agent in the space between the packaging material and the plastic soft bottle. Thereby, it is possible to detect the oxygen flowing into the space from the pinhole and confirm the presence of the pinhole. The oxygen detector is not particularly limited as long as its physical properties are changed by the presence of oxygen, but those whose color changes by the presence of oxygen are preferable.

  There are no particular restrictions on the form of the oxygen detector, although there are tablet and paper types. A specific example of the oxygen detector is Ageless Eye C (Mitsubishi Gas Chemical Co., Ltd.).

  In order to increase the accuracy of pinhole detection by the oxygen detector, it is preferable to install an oxygen scavenger in the space. If the oxygen concentration in the space is lowered by the oxygen scavenger, the sensitivity of the oxygen detector is improved. As the oxygen scavenger, a catechol-based oxygen scavenger that generates little carbon dioxide and absorbs it is preferable. A specific example of such an oxygen scavenger is Tamotsu D (Oji Tack Co., Ltd.).

  Specifically, as shown in FIG. 1, the ocular perfusate container of the present invention is a soft bottle X in a state in which the oxyglutathione-containing solution and the bicarbonate solution are separated into separate containers when not in use. It can be configured to be usable after a plurality of medicines are mixed by aseptically communicating a housing part containing these medicines during use.

  As shown in FIGS. 2 and 3, the soft bottle X contains a first containing member 10 containing an oxyglutathione-containing solution, a bicarbonate solution, and communicates with the first containing member 10 via a communication passage 61. The second accommodating member 20 is provided. The first storage member 10 forms a first chamber 11 that stores an oxyglutathione-containing solution, and the second storage member 20 forms a second chamber 21 that stores a bicarbonate solution. The communication path 61 is formed by a notch provided in the partition wall 60, and forms a mixing mechanism that can be sealed or opened by opening and closing the communication path 61 by the protruding piece 70.

  Further, the first housing member 10 is sealed by a lid member 30, and a cap member 40 capable of rotating the lid member 30 around an axis is engaged and mounted on the first housing member 10.

  The protruding piece 70 is engaged and fixed with respect to the cap member 40 or the lid member 30, and in the state where the lid member 30 and the cap member 40 are fitted to the first accommodating member 10, There is a contact portion 71 that can contact and seal the notch 61. When the cap member 40 is rotated around the axis with respect to the first housing member 10, the contact posture of the contact portion 71 with respect to the partition wall 60 can be changed. From the state in which the communication path 61 of the partition wall 60 is moved and closed so that the oxyglutathione-containing solution and the bicarbonate solution can be separated by the partition wall 60 and stored separately (see FIG. 4A). 61 is communicated so that the oxyglutathione-containing solution and the bicarbonate solution can be mixed (see FIG. 4B).

The first storage member 10 and the second storage member 20 can each be formed in a capacity corresponding to the amount of medicine to be stored. For example, the first chamber 11 of the first housing member 10 has a capacity of 20 mL, and the second chamber 21 of the second housing member 20 has a capacity of 480 mL.
The first housing member 10 and the second housing member 20 may be integrally molded, or may be formed as separate members and then connected so as to communicate with each other via the partition wall 60. .
The first housing member 10 and the second housing member 20 can be formed into arbitrary shapes, but the first housing member 10 rotates the lid member 30 and the cap member 40. If necessary, it is preferably molded into a cylindrical shape. In addition, the second housing member 20 can adopt a shape suitable for carrying when used, for example, a cylindrical shape or a tube shape.

  The lid member 30 is made of an elastic material such as a rubber material, and the entire formed lid member 30 is configured to be elastically deformable to some extent. The lid member 30 is provided with a needle sticking portion 31. Since the lid member 30 and the inner surface of the first housing member 10 can be in close contact with each other by molding in such a manner as to be elastically deformable, the oxyglutathione-containing solution contained in the first housing member 10 is Leakage from the first housing member 10 can be prevented, and the mixed and formed eye perfusate can be led out of the soft bottle X by the needle member pierced by the needle puncture portion 31.

  In addition, a hanging tool made of a ring-shaped member for hanging the soft bottle in an inverted posture is connected to the bottom of the soft bottle X.

  As shown in FIGS. 1 and 2, the soft bottle X is stored in a packaging material 80 in a state where the oxyglutathione-containing solution and the bicarbonate solution are separately stored and stored. The packaging material 80 is a self-supporting shape in which a resin film is bent to form a gusset at the bottom, and both sides are sealed, and together with the soft bottle X, a carbon dioxide-free oxygen scavenger 90 and In a state in which the oxygen detecting agent 91 is accommodated, the upper portion is sealed, and a space portion between the soft bottle X and the packaging material 80 is filled with air or nitrogen gas and sealed.

  Further, the packaging material 80 is provided with a notch (packaging material opening portion) 81 so that the packaging material can be easily opened when the soft bottle is taken out from the packaging material. A pair of notches 81 are provided at the neck portion height of the soft bottle X, and another pair of notches 81 are further provided below the notch 81 by the length of the body portion of the soft bottle X.

  When the packaging material 80 is opened from the notches 81, the cover member 100 is formed by cutting the packaging material 80 into a ring shape. The cover member 90 is used as a cover that suppresses expansion of the soft bottle X by pressurizing the inside of the soft bottle X when performing a pressure-type operation in a state of being attached to the soft bottle X. (See FIG. 5).

A more specific configuration in the above-described embodiment is shown below.
Fill a PP soft bottle with 480 mL of bicarbonate solution, weld a PP capsule with a communication system, pasteurize with high pressure steam, fill the PP capsule with 20 mL of oxyglutathione solution and plug the cap did. On the bottomed self-supporting packaging material consisting of films laminated in the order of alumina vapor-deposited PET-nylon-LLDPE from the outermost layer, the soft bottle is combined with an oxygen detector (Ageless Eye C Mitsubishi Gas Chemical Co., Ltd.) and an oxygen scavenger (TAMOTSU). D Oji Tac Co., Ltd.) and the upper part of the packaging material was sealed with a heat seal to obtain an eye perfusate container.

  In order to keep both components stable, the oxyglutathione solution and bicarbonate solution can be stored and used in the form of mixing both solutions separately when stored and used in a stable pH range, and the convenience of disposal can be enhanced. Therefore, for example, it can be applied to a container for an eye perfusate containing oxyglutathione as an active ingredient, which is used in ophthalmic surgery such as cataract surgery, vitreous surgery, and glaucoma surgery.

The figure which shows one Embodiment of the eye perfusate container of this invention. FIG. 3 is an exploded perspective view of the eye perfusate container in FIG. 1. Explanatory drawing of the principal part of a soft bottle. Explanatory drawing of a mixing mechanism. Explanatory drawing which uses a packaging material as a cover at the time of pressurization type surgery.

Explanation of symbols

X soft bottle 10 first housing member 20 second housing member 30 lid member 40 cap member 60 partition wall 61 notch portion 70 projecting piece 71 contact portion 80 packaging material 81 notch (packaging material opening portion)
90 oxygen absorber 91 oxygen detector 100 cover member

Claims (10)

  An ophthalmic perfusate container filled with an oxyglutathione-containing solution and a bicarbonate solution in a self-mixing plastic soft bottle capable of self-supporting.   The soft bottle has a first chamber and a second chamber that are water-tightly separated and formed by a partition wall, the oxyglutathione-containing solution is sealed in the first chamber, and a bicarbonate solution is sealed in the second chamber, The ocular perfusate container according to claim 1, further comprising a mixing mechanism that allows the oxyglutathione-containing solution and the bicarbonate solution to be mixed by communicating the first chamber and the second chamber during use.   The ocular perfusate container according to claim 1 or 2, wherein a packaging material made of gas-impermeable plastic for packaging the soft bottle is provided.   The ocular perfusate container according to claim 3, wherein the packaging material is a bottomed type capable of self-supporting.   The ocular perfusate container according to claim 3 or 4, wherein a space between the soft bottle and the packaging material is filled with air or nitrogen gas.   The ocular perfusate container according to claim 5, wherein an oxygen detection agent is sealed in a space portion between the soft bottle and the packaging material.   The ocular perfusate container according to claim 6, wherein an oxygen scavenger is further sealed in the space portion.   The ocular perfusate container according to claim 7, wherein the oxygen scavenger is a non-carbon dioxide generating type.   The eye perfusate container according to any one of claims 3 to 8, wherein a packaging material opening portion is provided at a neck height position of the soft bottle in the packaging material.   The packaging material is provided with a plurality of packaging material opening portions for opening the packaging material in a shape that can be wound and held around the body portion of the soft bottle, and the packaging material that has been opened from the packaging material opening portion is pressure-resistant to the soft bottle. The ocular perfusate container according to any one of claims 3 to 9, wherein the ophthalmic perfusate container is formed on a cover member capable of imparting a property.

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