JP2005029526A - Skin care preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for external use, capable of further enhancing wound-healing effects of a silicone of a skin care preparation for external use, and containing the silicone as an essential component. <P>SOLUTION: This skin care preparation for external use comprises a combination of the latter skin care preparation for external use containing the silicone as the essential component, and a sheet covering the skin care preparation for external use and having a tendency of assuming a negative static voltage. Preferably, the skin care preparation for external use containing the silicone as the essential component is obtained by formulating a silicone material or a solution containing the silicone material as a main component, and a bleaching agent. In another aspect, the skin care preparation for external use containing the silicone as the essential component is obtained by formulating the silicone material or the solution containing the silicone material as a main component, a bleaching agent and an ultraviolet-blocking agent. The sheet having the tendency of assuming the negative static voltage is a silicone sheet or a silicone rubber sheet. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an external preparation for skin comprising a combination of an external preparation for skin mainly composed of silicone and a sheet easily covering a negative electrostatic potential covering the skin to which the external preparation for skin is applied.

  Silicone does not regenerate the skin by simply applying the wound, keloid swell, jerking, firmness, color, pain, itch, etc. to the local area, but it normalizes the skin. It is known that there is an effect of normalization by removing local overstimulation due to the negative electrostatic potential of the silicone material. Clinically, itching and pain are generally required for 1 to 3 months, hardness is 1 to 4 months, swelling and convulsions are required for 3 to 6 months, and improvement of color tone requires 6 to 12 months.

  Silicone is used in the medical field such as treatment of wounds and keloids, but it is also used as a supplementary material for cosmetics as a lubricant, luster, water repellent and surfactant. (For example, refer to Patent Documents 1, 2, and 3.)

JP 2000-273019 A ([0003]) JP 2002-167319 A ([0023]) JP 2002-284664 A ([0009] to [0011])

  As described above, silicone is used in the medical field, but when used in the cosmetic field, it is merely used as an auxiliary material for cosmetic raw materials, and there are cosmetics (external skin preparations) that include medical use. Not.

In addition, as noted above, silicone has a wound healing effect caused by a negative electrostatic potential, and the applicant of the present invention is a skin external preparation mainly composed of silicone having a wound healing effect and a whitening effect. I applied for a patent.
The skin external preparation based on silicone in this patent application consists of a silicone material or a solution containing a silicone material as a main ingredient and a whitening agent, a silicone material or a solution containing a silicone material as a main ingredient, Containing a whitening agent and a UV blocking agent, consisting of a silicone material or a solution based on a silicone material, a whitening agent and a substance that promotes a negative electrostatic potential, a silicone material Or a skin external preparation mainly composed of silicone, comprising a solution mainly composed of a silicone material, a whitening agent, an ultraviolet blocking agent, and a substance that promotes a negative electrostatic potential, etc. Is described.
The applicant of the present application filed a patent application on the same date for a skin external preparation mainly composed of silicone having the pharmacological action of silicone and the pharmacological action of chitosan.
In this patent application, the external preparation for skin mainly composed of silicone is composed of a silicone material or a solution containing a silicone material as a main ingredient and chitosan, a silicone material or a solution containing a silicone material as a main ingredient, chitosan And an external preparation for skin mainly composed of silicone, characterized in that it contains a substance that promotes a negative electrostatic potential.
However, as a result of intensive studies, the present inventors have found that covering these external preparations containing silicone as a main component with a silicone sheet or the like further increases the electrostatic potential and increases the wound healing effect.

  Then, an object of this invention is to provide the skin external preparation which further increases the wound healing effect which the silicone of the skin external preparation which has silicone as a main component has.

In order to achieve the object, the external preparation for skin of the present invention comprises:
It consists of a combination of a skin external preparation containing silicone as a main component and a sheet easily covering a negative electrostatic potential covering the skin external preparation.
Moreover, it is preferable that the said skin external preparation which has the silicone as a main component mix | blends the solution which used the silicone raw material or the silicone raw material as a main material, and the whitening agent.
Further, it is preferable that the external preparation for skin containing silicone as a main component is a mixture of a silicone material or a solution containing a silicone material as a main material, a whitening agent and an ultraviolet blocking agent.
Further, the external preparation for skin mainly composed of silicone comprises a silicone material or a solution mainly composed of a silicone material, a whitening agent, and a substance that promotes a negative electrostatic potential. Is preferred.
Further, the above-mentioned skin external preparation containing silicone as a main component comprises a silicone material or a solution containing a silicone material as a main material, a whitening agent, an ultraviolet blocking agent and a substance that promotes a negative electrostatic potential. It is preferable that
In addition, it is preferable that the external preparation for skin containing silicone as a main component is a silicone material or a solution containing chitosan as a main material and chitosan.
Moreover, it is preferable that the external preparation for skin containing silicone as a main component is a mixture of a silicone material or a solution mainly containing a silicone material, chitosan, and a substance that promotes a negative electrostatic potential.
Furthermore, it is preferable that the sheet that easily has a negative electrostatic potential is a silicon sheet or a silicone rubber sheet.

  In addition to the above, there are vinylidene chloride, polyethylene, polypropylene, and the like, which are easy to have a negative electrostatic potential.

Hereinafter, test examples of the present invention will be described.
(Test Example 1)
Effect of silicone gel + whitening agent in combination with silicone sheet in humans
1. Assumptions We have found that some creams with a high degree of polymerization of silicone, or those containing only silicone gel material that does not contain moisture, have a high electrostatic potential, that is, a wound healing effect can be expected. It was. Therefore, focusing on the silicone gel or cream applied, the silicone sheet or PE or vinylidene chloride food storage film having a higher degree of polymerization than the gel has a high electrostatic potential, and the silicone gel or cream We have found that electrostatic potential increases and the wound healing effect can be expected by covering the sheet with these sheets and films, so this is used for acne scars and wrinkles that are dented scars in humans. Tested and found to be clearly more effective than silicone gel or cream alone.
Not only silicone alone, silicone gel such as PE powder and silicone powder, or those that increase the electrostatic potential of cream, but also in wound healing effect, to swell, pulling, hardness, color tone, pain itch I think that the effect can be expected to be further promoted even if it contains a supplement to the effect, for example, a whitening component, an antiallergic action, or a substance that cuts off ultraviolet rays.
2. Test Drug Silicone Gel + Whitening Agent: KSG-210: Dimethicone, (Dimethicone / PEG-10) Cross Polymer / (Dimethicone / PEG-15) Cross Polymer (Shin-Etsu Chemical, 98%) + α-Arbutin (Ezaki Glico) , 2%)
Silicone sheet: A thickness of 0.3 mm, which is well-familiar to the skin, was representatively used, and the size was cut into a size and shape according to the part to be used. The sheet was peeled off in the morning, washed thoroughly with warm water, dried, and used again.
Wrapping film for food packaging: Among food wrapping films that have been previously confirmed to have a high electrostatic potential in experiments, the size of the wrapping film depends on the portion where a typical commercial saran wrap (material name: vinylidene chloride) is used each time Cut into shape and used.

3． Examination of effects in humans Application and application method After applying the above KSG-210 + α-arbutin (hereinafter referred to as silicone gel cream) locally, it was planned to apply a silicone sheet. It was found that it is easier to apply a silicone gel cream to a sheet and apply it locally 5-10 minutes later. This is because the sheet has a high affinity for silicone gel cream and swells and swells, so the silicone gel cream applied to the sheet sufficiently infiltrates the sheet and the sheet swells is easier to handle and has high adhesiveness to the skin. It is. On the other hand, the wrap film was pasted on the silicone gel cream applied by cutting and applying a new one each time.
2) Pasting position

3) Effect judgment
A: A 28-year-old woman with acne scars was attached to the acne scars on the left cheek. Before going to bed, a sheet coated with silicone gel cream was affixed and left overnight. After peeling off the next morning, the face was washed to give a normal makeup. It was continued every night and observed every month to compare its effects. We will present the third month in which there is a difference in each of the six grades. The first and third months of redness and skin condition were evaluated on a 6-point scale (0: not recognized, 1: hardly recognized, 2: slightly recognized, 3: slightly recognized, 4: recognized, 5: equivalent)・ Comparison.
B: On the other hand, the acne scar on the right cheek was treated without any treatment.
C: Affixed to the left eye of a 56-year-old woman with fine wrinkles. Before going to bed, after applying basic makeup, a sheet coated with silicone gel cream was applied and left as it was overnight. After peeling off the next morning, the face was washed for daily makeup. It was continued every night and observed every month to compare its effects. We will present the third month in which there is a difference in each of the six grades. First and 3 months, the depth of wrinkles under the eyes and under the eyes and the condition of the skin are evaluated on a 6-point scale (0: not recognized, 1: hardly recognized, 2: slightly recognized, 3: slightly recognized, 4: recognized, 5: Observed).
D: On the other hand, the right-handed wrinkle was not treated and treated daily.
E: Another 62-year-old woman compared a silicone gel cream wrap on the left eye.
4) Results
(Gel stands for silicone gel cream)

(Before treatment) (After 3 months)

Findings: On the right side of the no treatment, it was judged that there was a part that disappeared over time and a part that occurred anew, but there was no change overall. On the other hand, silicone gel cream + sheet improved obviously.

Findings: In this case where clear wrinkles were observed on the eyes and under the eyes, a silicone gel cream + sheet treatment was performed. The person himself is pleased that it is clearly less conspicuous than the untreated right. The difference between the left and right became conspicuous, so with the wishes of the person, the test was completed in 3 months, and it was allowed to use silicone gel cream + sheet on the right side. Further, instead of the sheet, a typical salan wrap (material name: vinylidene chloride) was cut in the same manner as the sheet, and in this case, the cream was applied thinly and then covered and covered. After that, it was attached every day before going to bed like the seat. The wrap film was considered to have almost the same effect as the sheet. However, in the case of a sheet, it was thought that the sheet was cut into a certain shape, and if it was prepared from the beginning, it was easier to beat than wrapping because it was unnecessary to recreate it each time it was washed. Furthermore, the wrap film has drawbacks such as easy wrinkles and easy removal, and is actually difficult to use. These results are clearly more effective than silicone gel cream alone.
In these studies, no adverse events that were considered to be side effects were observed and no complaints were made.

Four. CONCLUSIONS Some silicone gels that have post-scratch healing properties, and at the same time have properties as gel or cream bases, are similar to other cosmetic and care products that care for skin with scars, pigmentation, etc. It is possible to create more useful products by combining materials with the above action.
Unlike other readily water-soluble creams, silicone gels or creams have a strong retention force on the skin, so that they can act on the skin for a long time. Since KSG-18 is fat-soluble, fat-soluble ascorbic acid isoaluminate (VCIP) can be applied to the skin continuously. Furthermore, since KSG-210 and KSG-710 also have water-absorbing groups, water-soluble physiologically active ingredients, coating ingredients from UV, etc., moisturizing ingredients, etc. are transferred from the gel or cream layer to the skin continuously and effectively. Since it is possible, the physiological action of the components on the skin can be secured for a long time.
From our previous experiments, it was found that the electrostatic potential was higher than the gel cream alone by covering it with a sheet or film of high electrostatic potential such as silicone sheet or vinylidene chloride or polyethylene. In addition, the gel or cream adheres to the concave scars and wrinkles that do not adhere to the sheet or film, and in combination with the sheet or film, in addition to pressing and moisturizing, it can act on the electrostatic potential and work effectively. This was confirmed in this clinical trial.
In addition, the thickness of the sheet is 0.1, 0.3, 0.5mm, etc. In the silicone gel cream application test and the touch test after application, 0.3mm is from the penetration time of the silicone gel cream, the flexibility of the sheet and the adhesion to the skin It turned out to be the most suitable.

Claims (8)

A skin external preparation comprising a combination of a skin external preparation containing silicone as a main component and a sheet easily covering a negative electrostatic potential covering the skin external preparation. The skin external preparation according to claim 1, wherein the skin external preparation containing silicone as a main component is a mixture of a silicone material or a solution mainly composed of a silicone material and a whitening agent. 2. The skin external preparation according to claim 1, wherein the skin external preparation containing silicone as a main component is a silicone material or a solution containing a silicone material as a main component, a whitening agent and an ultraviolet blocking agent. . The external preparation for skin mainly composed of silicone comprises a silicone material or a solution mainly composed of a silicone material, a whitening agent and a substance that promotes a negative electrostatic potential, The external preparation for skin according to claim 1. The skin external preparation mainly composed of silicone comprises a silicone material or a solution mainly composed of a silicone material, a whitening agent, an ultraviolet blocking agent, and a substance that promotes a negative electrostatic potential. The skin external preparation according to claim 1, wherein the skin external preparation is used. The skin external preparation according to claim 1, wherein the skin external preparation containing silicone as a main component is a mixture of a silicone material or a solution mainly containing a silicone material and chitosan. 2. The skin external preparation comprising silicone as a main component is a mixture of a silicone material or a solution mainly composed of a silicone material, chitosan and a substance that promotes a negative electrostatic potential. The skin external preparation described. The skin external preparation according to claim 1, wherein the sheet that easily has a negative electrostatic potential is a silicon sheet or a silicone rubber sheet.