JP2005021495A

JP2005021495A - Fluoroscopic image pick-up system

Info

Publication number: JP2005021495A
Application number: JP2003192126A
Authority: JP
Inventors: Masahiro Sakakibara; 正博榊原
Original assignee: Nemoto Kyorindo Co Ltd
Current assignee: Nemoto Kyorindo Co Ltd
Priority date: 2003-07-04
Filing date: 2003-07-04
Publication date: 2005-01-27
Anticipated expiration: 2023-07-04
Also published as: JP4623943B2

Abstract

<P>PROBLEM TO BE SOLVED: To provide a fluoroscopic image pickup system wherein even only one person can properly carry out a series of work of picking up a fluoroscopic image at a proper timing after injecting a myocardial stressing agent and a contrast medium at respectively proper timing. <P>SOLUTION: A medical fluid injection apparatus 100 and a fluoroscopic image pickup apparatus 300 communicate various kinds of data with each other to respectively control medical fluid injection and image pickup corresponding to the communicated data. Thus, injection of the myocardial stressing agent and the contrast medium and image pickup of the fluoroscopic image are integrally controlled and carried out at proper timing. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

【０００１】
【発明の属する技術分野】
本発明は、透視撮像装置で透視画像を撮像する被験者に薬液注入装置で薬液を注入する透視撮像システムに関し、特に、薬液として被験者の心筋に負荷を付与する心筋負荷薬と透視画像を造影する造影剤とを注入する透視撮像システムに関する。
【０００２】
【従来の技術】
現在、被験者の透視画像である断層画像を撮像する透視撮像装置としては、ＣＴ（ＣｏｍｐｕｔｅｄＴｏｍｏｇｒａｐｈｙ）スキャナ、ＭＲＩ（ＭａｇｎｅｔｉｃＲｅｓｏｎａｎｃｅＩｍａｇｉｎｇ）装置、ＰＥＴ（ＰｏｓｉｔｒｏｎＥｍｉｓｓｉｏｎＴｏｍｏｇｒａｐｈｙ）装置、超音波診断装置、等があり、被験者の透視画像である血管画像を撮像する医療装置としては、ＣＴアンギオ装置、ＭＲＡ（ＭＲＡｎｇｉｏ）装置、等がある。
【０００３】
上述のような装置を使用するとき、被験者に造影剤や生理食塩水などの薬液を注入することがあり、この注入を自動的に実行する薬液注入装置も実用化されている。このような薬液注入装置は、例えば、駆動モータやスライダ機構を有しており、薬液シリンジが着脱自在に装着される。
【０００４】
その薬液シリンジはシリンダ部材にピストン部材がスライド自在に挿入された構造からなり、そのシリンダ部材に造影剤や生理食塩水が充填される。このような薬液シリンジを延長チューブで被験者に連結して薬液注入機構に装着すると、薬液注入装置は、薬液注入機構でピストン部材とシリンダ部材とを個別に保持して相対移動させるので、薬液シリンジから被験者に造影剤や生理食塩水が注入される（例えば、特許文献１，２参照）。
【０００５】
また、現在では心筋虚血などの心疾患を検査するため、心筋に負荷を付与する心筋負荷薬を薬液として被験者に注入し、被験者の心臓周辺の透視画像を撮像することもある。その場合、例えば、最初に被験者に心筋負荷薬を注入し、この注入完了の直前に造影剤も注入する。これらの注入が完了すると透視画像を撮像することで、心筋に負荷が付与されている負荷状態の透視画像が造影されて撮像される。
【０００６】
つぎに、この撮像が完了すると被験者に中和剤を注入し、その注入完了から所定時間が経過すると造影剤を再度注入する。この注入が完了すると透視画像を再度撮像することにより、心筋に負荷が付与されていない安静状態の透視画像が造影されて撮像される。
【０００７】
なお、安静状態を最初に撮像してから負荷状態を撮像する手法もあり、その場合は当然ながら安静状態を撮像してから負荷状態を撮像するまでに中和剤を注入する必要はない。また、患部に必要最小限の造影剤を注入するため、造影剤を注入してから生理食塩水で後押しする手法もある。
【０００８】
なお、上述のように負荷状態と安静状態を撮像する一連の動作は、従来は作業者が薬液注入装置や透視撮像装置を順次操作することで実行されており、負荷状態と安静状態を撮像する一連の動作を自動的に実行するシステムなどの技術文献は発見されなかった。
【０００９】
【特許文献１】
特開２００２−１１０９６号
【特許文献２】
特開２００２−１０２３４３号
【００１０】
【発明が解決しようとする課題】
上述のように、負荷状態と安静状態を撮像する一連の動作は、作業者が薬液注入装置や透視撮像装置を順次操作することで実行されている。このため、その操作が煩雑であり、例えば、注入する薬液の順番を間違うなどの医療ミスが発生する可能性もある。
【００１１】
特に、透視画像を撮像する被験者に心筋負荷薬や造影剤などの薬液を注入するためには、薬液注入装置と透視撮像装置との両方を操作する必要があるので、作業者が一人の場合には作業が極めて煩雑であり、作業者が二人の場合には人員コストが倍加する。
【００１２】
さらに、心筋負荷薬や造影剤は注入が開始されてから患部に到達するまで所定時間が必要なので、一般的には薬液の注入を開始してから所定時間が経過したときに透視画像の撮像を開始することが好適であるが、これを適切に実行することは習熟を必要とする。特に、前述のように被験者に心筋負荷薬と造影剤と生理食塩水とを注入する場合、これらの注入を個々に適切なタイミングに開始させるとともに終了させることは、作業者に多分な習熟が必要とされる。
【００１３】
本発明は上述のような課題に鑑みてなされたものであり、作業者が一人でも心筋負荷薬や造影剤を適切なタイミングに注入して透視画像も適切なタイミングに撮像できる透視撮像システムを提供することを目的とする。
【００１４】
【課題を解決するための手段】
本発明の透視撮像システムは、透視撮像装置と薬液注入装置とを有しており、透視撮像装置は、被験者の透視画像を撮像し、薬液注入装置は、撮像される被験者に薬液を注入する。
【００１５】
本発明の第１の透視撮像システムでは、薬液注入装置は、負荷注入機構、造影注入機構、注入送信手段、注入受信手段、注入制御手段、を有しており、透視撮像装置は、画像撮像手段、撮像送信手段、撮像受信手段、撮像制御手段、を有している。
【００１６】
負荷注入機構は、被験者の心筋に負荷を付与する心筋負荷薬を薬液として被験者に注入し、造影注入機構は、透視画像を造影する造影剤を薬液として被験者に注入する。注入送信手段は、少なくとも負荷注入機構と造影注入機構との動作状態に対応した各種データなどを透視撮像装置に送信し、注入受信手段は、透視撮像装置から各種データを受信し、注入制御手段は、各種の受信データに対応して負荷注入機構と造影注入機構とを統合制御する。
【００１７】
画像撮像手段は、透視画像を撮像し、撮像送信手段は、少なくとも画像撮像手段の動作状態に対応した各種データなどを薬液注入装置に送信する。撮像受信手段は、薬液注入装置から各種データを受信し、撮像制御手段は、各種の受信データに対応して画像撮像手段を動作制御する。
【００１８】
従って、本発明の透視撮像システムでは、薬液注入装置と透視撮像装置とが各種データを相互通信し、その通信データに対応して薬液注入と画像撮像とが各々制御されるので、心筋負荷薬と造影剤との注入と透視画像の撮像とが統合制御される。
【００１９】
本発明の第２の透視撮像システムでは、薬液注入装置は、負荷注入機構、造影注入機構、注入送信手段、を有しており、透視撮像装置は、画像撮像手段、撮像受信手段、撮像制御手段、を有している。従って、本発明の透視撮像システムでは、薬液注入装置が透視撮像装置に各種データを送信し、その通信データに対応して画像撮像が制御されるので、心筋負荷薬と造影剤との注入に対応して透視画像の撮像が制御される。
【００２０】
本発明の第３の透視撮像システムでは、薬液注入装置は、負荷注入機構、造影注入機構、注入受信手段、注入制御手段、を有しており、透視撮像装置は、画像撮像手段、撮像送信手段、を有している。従って、本発明の透視撮像システムでは、透視撮像装置が薬液注入装置に各種データを送信し、その通信データに対応して薬液注入が制御されるので、心筋負荷薬と造影剤との注入が透視画像の撮像に対応して制御される。
【００２１】
なお、本発明で云う各種手段は、その機能を実現するように形成されていれば良く、例えば、所定の機能を発揮する専用のハードウェア、所定の機能がコンピュータプログラムにより付与されたデータ処理装置、コンピュータプログラムによりデータ処理装置の内部に実現された所定の機能、これらの組み合わせ、等で良い。
【００２２】
また、本発明で云う各種手段は、個々に独立した存在である必要もなく、複数の手段が１個の装置として形成されていること、ある手段が他の手段の一部であること、ある手段の一部と他の手段の一部とが重複していること、等も可能である。
【００２３】
また、本発明で云うコンピュータとは、コンピュータプログラムをデータ読取して対応する処理動作を実行できるハードウェアであれば良く、例えば、ＣＰＵ（ＣｅｎｔｒａｌＰｒｏｃｅｓｓｉｎｇＵｎｉｔ）を主体として、これに、ＲＯＭ（ＲｅａｄＯｎｌｙＭｅｍｏｒｙ）、ＲＡＭ（ＲａｎｄｏｍＡｃｃｅｓｓＭｅｍｏｒｙ）、Ｉ／Ｆ（Ｉｎｔｅｒｆａｃｅ）ユニット、等の各種デバイスが接続されたハードウェアなどで良い。
【００２４】
なお、本発明でコンピュータプログラムに対応した各種動作をコンピュータに実行させることは、各種デバイスをコンピュータに動作制御させることなども意味している。例えば、コンピュータに各種データを記憶させることは、コンピュータに固定されているＲＡＭ等の情報記憶媒体にＣＰＵが各種データを格納すること、コンピュータに交換自在に装填されているＦＤ（ＦｌｅｘｉｂｌｅＤｉｓｃ−ｃａｒｔｒｉｄｇｅ）等の情報記憶媒体にＣＰＵがＦＤＤ（ＦＤＤｒｉｖｅ）で各種データを格納すること、等で良い。
【００２５】
また、本発明で云う情報記憶媒体とは、コンピュータに各種処理を実行させるためのコンピュータプログラムが事前に格納されたハードウェアであれば良く、例えば、コンピュータに固定されているＲＯＭおよびＨＤＤ（ＨａｒｄＤｉｓｃＤｒｉｖｅ）、コンピュータに交換自在に装填されるＣＤ（ＣｏｍｐａｃｔＤｉｓｃ）−ＲＯＭおよびＦＤ、等で実施することが可能である。
【００２６】
【発明の実施の形態】
［実施の形態の構成］
本発明の実施の一形態を図面を参照して以下に説明する。本実施の形態の薬液注入システム１０００は、図１ないし図４に示すように、薬液注入装置１００、薬液シリンジ２００、透視撮像装置であるＭＲＩ装置３００、からなり、ＭＲＩ装置３００で透視画像が撮像される被験者（図示せず）に、薬液注入装置１００が薬液シリンジ２００から造影剤などの薬液を注入する。
【００２７】
ＭＲＩ装置３００は、図１および図２に示すように、画像撮像手段である透視撮像ユニット３０１と撮像制御ユニット３０２とを有しており、その透視撮像ユニット３０１と撮像制御ユニット３０２とは通信ネットワーク３０３で有線接続されている。透視撮像ユニット３０１は被験者から透視画像を撮像し、撮像制御ユニット３０２は透視撮像ユニット３０１を動作制御する。
【００２８】
薬液シリンジ２００は、図４に示すように、シリンダ部材２１０とピストン部材２２０からなり、シリンダ部材２１０にピストン部材２２０がスライド自在に挿入されている。シリンダ部材２１０は、中空の円筒形に形成されており、末端の開口から内部にピストン部材２２０が挿入されている。シリンダ部材２１０の末端外周にはシリンダフランジ２１１が形成されており、ピストン部材２２０の末端外周にはピストンフランジ２２１が形成されている。
【００２９】
本形態の薬液注入装置１００は、図３に示すように、１個の注入制御ユニット１０１と一対の注入ヘッド１１０とが別体に形成されており、その１個の注入制御ユニット１０１と一対の注入ヘッド１１０とが通信ケーブル１０２で有線接続されている。
【００３０】
注入ヘッド１１０は、装着される薬液シリンジ２００のシリンダ部材２１０にピストン部材２２０を圧入して被験者に薬液を注入し、注入制御ユニット１０１は、注入ヘッド１１０を動作制御する。このため、図１に示すように、注入制御ユニット１０１はコンピュータユニット１２０が内蔵されており、このコンピュータユニット１２０は、ＭＲＩ装置３００の撮像制御ユニット３０２とも通信ネットワーク１２２で有線接続されている。
【００３１】
注入制御ユニット１０１は、操作パネル１０３、ディスプレイパネルであるタッチパネル１０４、スピーカユニット１０５、等が本体ハウジング１０６の前面に配置されており、別体のコントローラユニット１０７が接続コネクタ１０８で有線接続されている。
【００３２】
一対の注入ヘッド１１０は、図３に示すように、キャスタスタンド１１１の上端に可動アーム１１２で装着されており、その各々のヘッド本体１１３の上面には、２個の薬液シリンジ２００が着脱自在に個々に装着される半円筒形の２列の凹部１１４が形成されている。
【００３３】
この凹部１１４の前部には、薬液シリンジ２００のシリンダフランジ２１１を着脱自在に保持する異形部１１５が形成されており、凹部１１４の後方には、ピストンフランジ２２１を保持してスライド移動させるシリンジ駆動機構１１６が配置されている。
【００３４】
シリンジ駆動機構１１６は、駆動源として磁界を発生しない超音波モータ（図示せず）を有しており、この超音波モータが、燐青銅合金（Ｃｕ＋Ｓｎ＋Ｐ）、チタン合金（Ｔｉ−６Ａｌ−４Ｖ）、マグネシウム合金（Ｍｇ＋Ａｌ＋Ｚｎ）、などの非磁性体で形成されている。
【００３５】
本形態の薬液注入装置１００は、上述のように一対の注入ヘッド１１０の各々が２個の凹部１１４およびシリンジ駆動機構１１６を有するので、ここに造影注入機構１２１、生食注入機構１２２、負荷注入機構１２３、中和注入機構１２４、が形成されている。
【００３６】
造影注入機構１２１は、造影剤が充填されている薬液シリンジ２００を駆動し、生食注入機構１２２は、生理食塩水が充填されている薬液シリンジ２００を駆動する。負荷注入機構１２３は、心筋負荷薬が充填されている薬液シリンジ２００を駆動し、中和注入機構１２４は、中和剤が充填されている薬液シリンジ２００を駆動する。
【００３７】
なお、本形態の薬液注入システム１０００では、各種サイズの薬液シリンジ２００が用意されているので、図４に示すように、注入ヘッド１１０の凹部１１４には最大サイズの薬液シリンジ２００のみ直接に装着され、最大以外のサイズの薬液シリンジ２００は各々に専用のシリンダアダプタ２３０を介して装着される。
【００３８】
本形態の薬液注入装置１００は、図１に示すように、コンピュータユニット１２０に各部が接続されており、コンピュータユニット１２０が実装されているコンピュータプログラムに対応して各部を統合制御する。同様に、ＭＲＩ装置３００も撮像制御ユニット３０２がコンピュータユニットからなり、この撮像制御ユニット３０２が実装されているコンピュータプログラムに対応して透視撮像ユニット３０１を動作制御する。
【００３９】
さらに、本形態の透視撮像システム１０００では、薬液注入装置１００のコンピュータユニット１２０とＭＲＩ装置３００の撮像制御ユニット３０２とは各種データを相互通信し、各々の各種動作を協調制御する。このため、薬液注入装置１００のコンピュータユニット１２０は、注入送信手段、注入受信手段、注入制御手段、等の各種手段として機能し、ＭＲＩ装置３００の撮像制御ユニット３０２は、撮像送信手段、撮像受信手段、撮像制御手段、等の各種手段として機能する。
【００４０】
より具体的には、薬液注入装置１００は、コンピュータユニット１２０が入力操作された設定データなどに対応して各種の注入機構１２１〜１２４を統合制御し、その動作状態に対応した各種データなどをＭＲＩ装置３００の撮像制御ユニット３０２に送信する。
【００４１】
一方、ＭＲＩ装置３００では、撮像制御ユニット３０２が入力操作された設定データなどに対応して透視撮像ユニット３０１を動作制御し、その動作状態に対応した各種データなどを薬液注入装置１００のコンピュータユニット１２０に送信する。
【００４２】
さらに、薬液注入装置１００は、コンピュータユニット１２０がＭＲＩ装置３００の撮像制御ユニット３０２から各種データを受信し、その各種の受信データにも対応して各種の注入機構１２１〜１２４を統合制御する。同様に、ＭＲＩ装置３００も、撮像制御ユニット３０２が薬液注入装置１００のコンピュータユニット１２０から各種データを受信し、その各種の受信データにも対応して透視撮像ユニット３０１を動作制御する。
【００４３】
本形態の透視撮像システム１０００では、上述のように薬液注入装置１００とＭＲＩ装置３００とが協調動作することにより、図５に示すように、最初に負荷注入機構１２３で心筋負荷薬の注入を６分間まで実行し、その完了の２分前から１分間まで造影注入機構１２１で造影剤の注入を実行する。この造影剤の注入が完了すると同時に生食注入機構１２２で生理食塩水の注入を１分間まで実行し、この生理食塩水と心筋負荷薬との注入完了と同時に透視撮像ユニット３０１で負荷状態の透視画像の撮像を数１０秒まで実行する。
【００４４】
この撮像完了と同時に中和注入機構１２４で中和剤の注入を１分間まで実行し、この中和剤の注入完了から１分半ほどの所定時間が経過すると、造影注入機構１２１で造影剤の注入を１分間まで実行する。この造影剤の注入が完了すると同時に生食注入機構１２２で生理食塩水の注入を１分間まで実行し、この生理食塩水の注入完了と同時に透視撮像ユニット３０１で安静状態の透視画像の撮像を数１０秒まで実行する。
【００４５】
なお、前述のような薬液注入装置１００とＭＲＩ装置３００との各種手段は、必要によりタッチパネル１０４などのハードウェアを利用して実現されるが、その主体はコンピュータユニット１２０および撮像制御ユニット３０２が実装されているコンピュータプログラムに対応して各種動作を実行することにより実現されている。
【００４６】
このようなコンピュータプログラムは、例えば、最初に負荷注入機構１２３で心筋負荷薬の注入を６分間まで実行すること、その完了の２分前から１分間まで造影注入機構１２１で造影剤の注入を実行すること、この造影剤の注入が完了すると同時に生食注入機構１２２で生理食塩水の注入を１分間まで実行すること、この生理食塩水と心筋負荷薬との注入完了と同時に透視撮像ユニット３０１で負荷状態の透視画像の撮像を数１０秒まで実行すること、この撮像完了と同時に中和注入機構１２４で中和剤の注入を１分間まで実行すること、この中和剤の注入完了から１分半ほどの所定時間が経過すると造影注入機構１２１で造影剤の注入を１分間まで実行すること、この造影剤の注入が完了すると同時に生食注入機構１２２で生理食塩水の注入を１分間まで実行すること、この生理食塩水の注入完了と同時に透視撮像ユニット３０１で安静状態の透視画像の撮像を数１０秒まで実行すること、等の処理動作を実行させるようにコンピュータユニット１２０にファームウェアなどで実装されている。
【００４７】
［実施の形態の作用］
上述のような構成において、本実施の形態の薬液注入システム１０００では、薬液注入装置１００で被験者に心筋負荷薬や造影剤を注入し、その被験者からＭＲＩ装置３００で透視画像を撮像することにより、被験者の心筋に負荷を付与した負荷状態と負荷を付与しない安静状態との透視画像を撮像することができる。
【００４８】
その場合、作業者は被験者をＭＲＩ装置３００の透視撮像ユニット３０１に位置させ、造影剤と生理食塩水と心筋負荷薬と中和剤との薬液シリンジ２００を各々用意する。そして、これら４本の薬液シリンジ２００を被験者に延長チューブ（図示せず）などで適宜連結し、薬液注入装置１００の４つの注入機構１２１〜１２４に個々に装填する。
【００４９】
このような状態で、例えば、作業者が薬液注入装置１００の操作パネル１０３に作業開始を入力操作すると、図６に示すように、これを検知した薬液注入装置１００は（ステップＳ１）、作業開始をＭＲＩ装置３００にデータ送信する（ステップＳ２）。
【００５０】
そして、薬液注入装置１００は、上述のデータ送信に対応してＭＲＩ装置３００から作業開始がデータ返信されると（ステップＳ３）、一連の作業を開始するが（ステップＳ９〜）、作業開始をデータ受信しない場合やエラーガイダンスをデータ受信した場合は（ステップＳ３）、“××エラーです。ＭＲＩ装置を確認して下さい”などのエラーガイダンスをタッチパネル１０４やスピーカユニット１０５で報知出力して初期状態に復帰する（ステップＳ７）。
【００５１】
なお、ＭＲＩ装置３００は、その撮像制御ユニット３０２に作業開始が入力操作されていない状態で、図８に示すように、上述のように薬液注入装置１００から作業開始をデータ受信すると（ステップＴ４）、自己の状態を診断し（ステップＴ５）、これでエラーが検知されないと作業開始を薬液注入装置１００にデータ返信する（ステップＴ８）。
【００５２】
なお、ＭＲＩ装置３００は、上述の自己診断でエラーが検知されると（ステップＴ５）、エラーガイダンスを薬液注入装置１００にデータ返信し（ステップＴ６）、“××エラーです。〜を確認して下さい”などのエラーガイダンスを報知出力して初期状態に復帰する（ステップＴ７）。
【００５３】
また、作業者が最初に薬液注入装置１００ではなくＭＲＩ装置３００に作業開始を入力操作した場合も、図８および図６に示すように、上述の場合と同様にＭＲＩ装置３００と薬液注入装置１００との相互通信により作業開始が相互に確認される（ステップＴ１〜Ｔ３，Ｓ４〜Ｓ８）
そして、図６に示すように、作業開始を確認した薬液注入装置１００は、最初に負荷注入機構１２３を作動させて被験者への心筋負荷薬の注入を開始し（ステップＳ９）、図５に示すように、その注入開始から４分が経過すると（ステップＳ１０）、造影注入機構１２１を作動させて造影剤の注入を開始する（ステップＳ１１）。
【００５４】
その注入開始から１分が経過すると（ステップＳ１２）、造影注入機構１２１が停止されて造影剤の注入が完了されるとともに、生食注入機構１２２が作動されて生理食塩水の注入が開始される（ステップＳ１３）。そして、この注入開始から１分が経過すると（ステップＳ１４）、負荷注入機構１２３と生食注入機構１２２とが停止されて心筋負荷薬と生理食塩水との注入が完了される（ステップＳ１５）。
【００５５】
すると、薬液注入装置１００は注入完了をＭＲＩ装置３００にデータ送信するので（ステップＳ１６）、図８に示すように、この注入完了をデータ受信したＭＲＩ装置３００は（ステップＴ９）、心筋負荷薬と造影剤とが注入された被験者から負荷状態の透視画像を撮像する（ステップＴ１０）。
【００５６】
この負荷状態の撮像が完了すると（ステップＴ１１）、ＭＲＩ装置３００は薬液注入装置１００に撮像完了をデータ送信するので（ステップＴ１２）、図７に示すように、この撮像完了をデータ受信した薬液注入装置１００は（ステップＳ１７）、中和注入機構１２４を作動させて被験者への中和剤の注入を開始し（ステップＳ１８）、図５に示すように、その注入開始から１分が経過すると（ステップＳ１９）、中和注入機構１２４を停止させて中和剤の注入を完了する（ステップＳ２０）。
【００５７】
この注入完了から所定の待機時間が経過すると（ステップＳ２１）、造影注入機構１２１が作動されて造影剤の注入が再度開始される（ステップＳ２２）。この注入開始から１分が経過すると（ステップＳ２３）、造影注入機構１２１が停止されて造影剤の注入が再度完了されるとともに、生食注入機構１２２が作動されて生理食塩水の注入が再度開始される（ステップＳ２４）。
【００５８】
そして、この注入開始から１分が経過すると（ステップＳ２４）、生食注入機構１２２が停止されて生理食塩水の注入が再度完了される（ステップＳ２５）。すると、薬液注入装置１００は再度の注入完了をＭＲＩ装置３００にデータ送信するので（ステップＳ２６）、図８に示すように、この再度の注入完了をデータ受信したＭＲＩ装置３００は（ステップＴ１３）、心筋負荷薬が中和されて造影剤が注入された被験者から安静状態の透視画像を撮像する（ステップＴ１４，Ｔ１５）。
【００５９】
［実施の形態の効果］
本実施の形態の薬液注入システム１０００では、上述のように薬液注入装置１００とＭＲＩ装置３００とが各種データを相互通信し、その通信データに対応して薬液注入と画像撮像とが各々制御される。このため、各種薬液の注入と透視画像の撮像とを統合制御することができるので、被験者に心筋負荷薬や造影剤を個々に適切なタイミングで注入して透視画像を適切なタイミングに撮像する一連の作業を、作業者が一人でも適切に実行することができる。
【００６０】
しかも、本形態の薬液注入システム１０００では、薬液注入装置１００が被験者に中和剤を注入することもできるので、被験者に心筋負荷薬を注入して負荷状態の透視画像を撮像してから、中和剤を注入して安静状態の透視画像を即座に撮像することができる。さらに、薬液注入装置１００が被験者に生理食塩水を注入することもできるので、被験者の患部に注入する造影剤を必要最小限とすることができ、ランニングコストを削減できるとともに被験者の身体負担も軽減することができる。
【００６１】
特に、本形態の薬液注入システム１０００では、上述のように心筋負荷薬と造影剤だけでなく中和剤と生理食塩水も被験者に注入することができるが、その全部の注入を適切に管理できるので、極度に煩雑な一連の作業を自動的に実行することができる。
【００６２】
さらに、本形態の薬液注入システム１０００では、薬液注入装置１００の駆動源が非磁性体で形成されていて磁界を発生しない超音波モータからなるので、ＭＲＩ装置３００の近傍で薬液注入装置１００を問題なく利用することができる。
【００６３】
［実施の形態の変形例］
本発明は本実施の形態に限定されるものではなく、その要旨を逸脱しない範囲で各種の変形を許容する。例えば、上記形態では薬液注入装置１００をＭＲＩ装置３００の近傍で使用することを想定したが、これをＣＴスキャナやアンギオ装置や超音波診断装置などの近傍で使用することも可能である。
【００６４】
また、上記形態では薬液注入装置１００とＭＲＩ装置３００とが相互通信することを例示したが、その通信方向を一方のみとすることも可能である。例えば、薬液注入装置１００からＭＲＩ装置３００にデータ送信のみ実行される場合、ＭＲＩ装置３００は薬液注入装置１００の注入動作に連動して画像撮像を実行することが好適である。この場合、薬液注入装置１００はＭＲＩ装置３００の撮像完了を直接に確認することはできないので、事前に設定されたタイムスケジュールに対応して薬液注入を実行することが好適である。
【００６５】
一方、ＭＲＩ装置３００から薬液注入装置１００にデータ送信のみ実行する場合、ＭＲＩ装置３００が薬液注入装置１００に作業開始をデータ送信することで、薬液注入装置１００が事前に設定されたタイムスケジュールに対応して薬液注入を実行することが好適である。この場合、ＭＲＩ装置３００は薬液注入装置１００の注入完了を直接に確認することはできないので、やはり事前に設定されたタイムスケジュールに対応して画像撮像を実行することが好適である。
【００６６】
さらに、上記形態では最初に被験者に心筋負荷薬を注入して負荷状態を撮像してから中和剤を注入して安静状態を撮像することを例示したが、図９に示すように、最初に安静状態を撮像してから負荷状態を撮像することで中和剤の注入を無用とすることも可能である。また、上記形態では生理食塩水で後押しすることで患部まで注入する造影剤の容量を必要最小限とすることを例示したが、図９に示すように、生理食塩水で後押しすることなく造影剤を患部まで注入することも可能である。
【００６７】
さらに、上記形態ではコンピュータユニット１２０や撮像制御ユニット３０２が実装されているコンピュータプログラムに対応して動作することにより、薬液注入装置１００およびＭＲＩ装置３００の各種機能として各種手段が論理的に実現されることを例示した。
【００６８】
しかし、このような各種手段の各々を固有のハードウェアとして形成することも可能であり、一部をソフトウェアとしてコンピュータユニット１２０や撮像制御ユニット３０２に実装するとともに一部をハードウェアとして形成することも可能である。
【００６９】
【発明の効果】
本発明の第１の透視撮像システムでは、薬液注入装置と透視撮像装置とが各種データを相互通信し、その通信データに対応して薬液注入と画像撮像とが各々制御されることにより、心筋負荷薬と造影剤との注入と透視画像の撮像とを統合制御することができるので、被験者に心筋負荷薬と造影剤とを個々に適切なタイミングで注入してから透視画像を適切なタイミングに撮像する一連の作業を作業者が一人でも適切に実行することができる。
【００７０】
本発明の第２の透視撮像システムでは、薬液注入装置が透視撮像装置に各種データを送信し、その通信データに対応して画像撮像が制御されることにより、心筋負荷薬と造影剤との注入に対応して透視画像の撮像を制御することができるので、被験者に心筋負荷薬と造影剤とを個々に適切なタイミングで注入してから透視画像を適切なタイミングに撮像する一連の作業を作業者が一人でも適切に実行することができる。
【００７１】
本発明の第３の透視撮像システムでは、透視撮像装置が薬液注入装置に各種データを送信し、その通信データに対応して薬液注入が制御されることにより、心筋負荷薬と造影剤との注入を透視画像の撮像に対応して制御することができるので、被験者に心筋負荷薬と造影剤とを個々に適切なタイミングで注入してから透視画像を適切なタイミングに撮像する一連の作業を作業者が一人でも適切に実行することができる。
【図面の簡単な説明】
【図１】本発明の実施の形態の透視撮像システムの回路構造を示すブロック図である。
【図２】透視撮像システムの外観を示す斜視図である。
【図３】薬液注入装置の外観を示す斜視図である。
【図４】薬液注入装置の注入ヘッドに薬液シリンジを装着する状態を示す斜視図である。
【図５】透視撮像システムによる透視撮像方法を示すタイムチャートである。
【図６】薬液注入装置の処理動作の前半部分を示すフローチャートである。
【図７】後半部分を示すフローチャートである。
【図８】ＭＲＩ装置の処理動作を示すフローチャートである。
【図９】一変形例の透視撮像方法を示すタイムチャートである。
【符号の説明】
１００薬液注入装置
１２０各種手段として機能するコンピュータユニット
１２１造影注入機構
１２２生食注入機構
１２３負荷注入機構
１２４中和注入機構
３００透視撮像装置であるＭＲＩ装置
３０１透視撮像ユニット
３０２各種手段として機能する撮像制御ユニット[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a fluoroscopic imaging system in which a liquid medicine is injected into a subject who takes a fluoroscopic image with a fluoroscopic imaging apparatus, and in particular, a contrast medium that contrasts a myocardial loading drug that applies a load to the myocardium of a subject as a liquid medicine and a fluoroscopic image. The present invention relates to a fluoroscopic imaging system for injecting an agent.
[0002]
[Prior art]
Currently, there are CT (Computed Tomography) scanners, MRI (Magnetic Resonance Imaging) devices, PET (Positron Emission Tomography) devices, ultrasound diagnostic devices, etc. as fluoroscopic imaging devices that capture tomographic images that are fluoroscopic images of subjects. Examples of medical devices that capture a blood vessel image that is a fluoroscopic image of a subject include a CT angio device and an MRA (MR Angio) device.
[0003]
When using the apparatus as described above, a chemical liquid such as a contrast medium or physiological saline may be injected into the subject, and a chemical liquid injection apparatus that automatically executes this injection has also been put into practical use. Such a chemical solution injection device has, for example, a drive motor and a slider mechanism, and a chemical solution syringe is detachably attached thereto.
[0004]
The drug solution syringe has a structure in which a piston member is slidably inserted into a cylinder member, and the cylinder member is filled with a contrast medium or physiological saline. When such a drug solution syringe is connected to a subject with an extension tube and attached to the drug solution injection mechanism, the drug solution injection device holds the piston member and the cylinder member separately with the drug solution injection mechanism and moves them relative to each other. A contrast medium and physiological saline are injected into the subject (for example, see Patent Documents 1 and 2).
[0005]
Currently, in order to examine heart diseases such as myocardial ischemia, a myocardial loading drug that imparts a load on the myocardium is injected into the subject as a medicinal solution, and a fluoroscopic image around the subject's heart is sometimes captured. In that case, for example, a myocardial stress drug is first injected into the subject, and a contrast agent is also injected immediately before the completion of the injection. When these injections are completed, a fluoroscopic image is captured, and a fluoroscopic image in a loaded state in which a load is applied to the myocardium is imaged and captured.
[0006]
Next, when this imaging is completed, a neutralizing agent is injected into the subject, and when a predetermined time has elapsed from the completion of the injection, the contrast agent is injected again. When this injection is completed, a fluoroscopic image is taken again, and a fluoroscopic image in a resting state in which no load is applied to the myocardium is imaged.
[0007]
In addition, there is a method of imaging a load state after first imaging a resting state. In this case, naturally, it is not necessary to inject a neutralizing agent after imaging the resting state and imaging the load state. In addition, in order to inject a necessary minimum amount of contrast medium into the affected area, there is a method in which a contrast medium is injected and then boosted with physiological saline.
[0008]
In addition, as described above, a series of operations for imaging the load state and the resting state are conventionally performed by an operator sequentially operating the chemical injection device and the fluoroscopic imaging device, and images the load state and the resting state. No technical literature such as a system that automatically executes a series of operations has been found.
[0009]
[Patent Document 1]
JP 2002-11096 A
[Patent Document 2]
JP 2002-102343 A
[0010]
[Problems to be solved by the invention]
As described above, a series of operations for imaging the load state and the resting state are executed by the operator sequentially operating the chemical liquid injector and the fluoroscopic imaging device. For this reason, the operation is complicated, and for example, there is a possibility that a medical error such as a wrong order of the liquid medicines to be injected may occur.
[0011]
In particular, in order to inject a medical solution such as a myocardial loading drug or a contrast agent into a subject who captures a fluoroscopic image, it is necessary to operate both the chemical injection device and the fluoroscopic imaging device. The work is extremely complicated, and when there are two workers, the personnel cost is doubled.
[0012]
Furthermore, since the myocardial loading drug or contrast medium requires a predetermined time from the start of injection until it reaches the affected area, generally a fluoroscopic image is taken when a predetermined time has elapsed since the start of the injection of the drug solution. Although it is preferred to start, doing this properly requires proficiency. In particular, when injecting a myocardial stress agent, a contrast medium, and physiological saline into a subject as described above, it is necessary for the operator to be proficient at starting and ending these injections at appropriate timings individually. It is said.
[0013]
The present invention has been made in view of the above-described problems, and provides a fluoroscopic imaging system capable of imaging a fluoroscopic image at an appropriate timing by injecting a myocardial stress drug or a contrast medium at an appropriate timing even by one worker. The purpose is to do.
[0014]
[Means for Solving the Problems]
The fluoroscopic imaging system of the present invention includes a fluoroscopic imaging device and a chemical solution injection device. The fluoroscopic imaging device images a fluoroscopic image of a subject, and the chemical solution injection device injects a chemical solution to the subject to be imaged.
[0015]
In the first fluoroscopic imaging system of the present invention, the chemical liquid injector includes a load injection mechanism, a contrast injection mechanism, an injection transmitter, an injection receiver, and an injection controller. Imaging transmission means, imaging reception means, and imaging control means.
[0016]
The load injection mechanism injects a myocardial loading drug that applies a load to the subject's myocardium as a drug solution into the subject, and the contrast injection mechanism injects a contrast agent that contrasts a fluoroscopic image as a drug solution into the subject. The injection transmitting means transmits at least various data corresponding to the operating states of the load injection mechanism and the contrast injection mechanism to the fluoroscopic imaging apparatus, the injection receiving means receives various data from the fluoroscopic imaging apparatus, and the injection control means The load injection mechanism and the contrast injection mechanism are integrated and controlled in accordance with various received data.
[0017]
The image capturing means captures a fluoroscopic image, and the image capturing and transmitting means transmits at least various data corresponding to the operation state of the image capturing means to the drug solution injector. The imaging receiving means receives various data from the chemical injection device, and the imaging control means controls the operation of the image imaging means corresponding to the various received data.
[0018]
Therefore, in the fluoroscopic imaging system of the present invention, the medical fluid injector and the fluoroscopic imaging device mutually communicate various data, and the chemical fluid injection and the imaging are controlled in accordance with the communication data. The injection with the contrast agent and the imaging of the fluoroscopic image are integratedly controlled.
[0019]
In the second fluoroscopic imaging system of the present invention, the chemical liquid injector includes a load injection mechanism, a contrast injection mechanism, and an injection transmission unit. The fluoroscopic imaging device includes an image imaging unit, an imaging reception unit, and an imaging control unit. ,have. Therefore, in the fluoroscopic imaging system of the present invention, the chemical injection device transmits various data to the fluoroscopic imaging device, and the imaging is controlled in accordance with the communication data, so that the myocardial loading drug and contrast agent can be injected. Thus, the imaging of the fluoroscopic image is controlled.
[0020]
In the third fluoroscopic imaging system of the present invention, the chemical liquid injector includes a load injection mechanism, a contrast injection mechanism, an injection receiving unit, and an injection control unit. The fluoroscopic imaging device includes an image imaging unit and an imaging transmission unit. ,have. Therefore, in the fluoroscopic imaging system of the present invention, the fluoroscopic imaging device transmits various data to the chemical solution injector, and the chemical solution injection is controlled in accordance with the communication data. Control is performed in response to image capturing.
[0021]
The various means referred to in the present invention need only be formed so as to realize the function. For example, dedicated hardware that exhibits a predetermined function, a data processing apparatus provided with a predetermined function by a computer program A predetermined function realized in the data processing apparatus by a computer program, a combination thereof, or the like may be used.
[0022]
In addition, the various means referred to in the present invention do not have to be independent of each other, a plurality of means are formed as one device, and a certain means is a part of other means. It is also possible that a part of the means overlaps with a part of the other means.
[0023]
Further, the computer according to the present invention may be hardware that can read a computer program and execute a corresponding processing operation. For example, a CPU (Central Processing Unit) is mainly used as a ROM (Read Only). Memory, RAM (Random Access Memory), I / F (Interface) unit, etc. may be used as hardware.
[0024]
Note that causing the computer to execute various operations corresponding to the computer program in the present invention also means causing the computer to control the operation of various devices. For example, storing various data in the computer means that the CPU stores various data in an information storage medium such as a RAM fixed to the computer, or an FD (Flexible Disc-cartridge) loaded in the computer in a replaceable manner. For example, the CPU may store various data in an information storage medium such as FDD (FD Drive).
[0025]
The information storage medium referred to in the present invention may be hardware in which a computer program for causing a computer to execute various processes is stored in advance. For example, a ROM and a HDD (Hard Disc) fixed to the computer. Drive), a CD (Compact Disc) -ROM and an FD, which are exchangeably loaded in a computer, and the like.
[0026]
DETAILED DESCRIPTION OF THE INVENTION
[Configuration of the embodiment]
An embodiment of the present invention will be described below with reference to the drawings. As shown in FIGS. 1 to 4, the chemical solution injection system 1000 according to the present embodiment includes a chemical solution injection device 100, a chemical solution syringe 200, and an MRI apparatus 300 that is a fluoroscopic imaging apparatus, and a fluoroscopic image is captured by the MRI apparatus 300. A chemical solution injection device 100 injects a chemical solution such as a contrast medium from a chemical solution syringe 200 into a subject (not shown).
[0027]
As shown in FIGS. 1 and 2, the MRI apparatus 300 includes a fluoroscopic imaging unit 301 and an imaging control unit 302 that are image imaging means. The fluoroscopic imaging unit 301 and the imaging control unit 302 are connected to a communication network. 303 is wired. The fluoroscopic imaging unit 301 captures a fluoroscopic image from the subject, and the imaging control unit 302 controls the operation of the fluoroscopic imaging unit 301.
[0028]
As shown in FIG. 4, the chemical syringe 200 includes a cylinder member 210 and a piston member 220, and the piston member 220 is slidably inserted into the cylinder member 210. The cylinder member 210 is formed in a hollow cylindrical shape, and the piston member 220 is inserted into the inside from the opening at the end. A cylinder flange 211 is formed on the outer periphery of the end of the cylinder member 210, and a piston flange 221 is formed on the outer periphery of the end of the piston member 220.
[0029]
As shown in FIG. 3, the chemical injection device 100 according to the present embodiment includes a single injection control unit 101 and a pair of injection heads 110 that are formed separately, and the single injection control unit 101 and a pair of injection heads. The injection head 110 is wired with a communication cable 102.
[0030]
The injection head 110 press-fits the piston member 220 into the cylinder member 210 of the chemical syringe 200 to be attached to inject the chemical into the subject, and the injection control unit 101 controls the operation of the injection head 110. Therefore, as shown in FIG. 1, the injection control unit 101 includes a computer unit 120, and the computer unit 120 is also connected to the imaging control unit 302 of the MRI apparatus 300 by a communication network 122.
[0031]
In the injection control unit 101, an operation panel 103, a touch panel 104 which is a display panel, a speaker unit 105, and the like are arranged on the front surface of the main body housing 106, and a separate controller unit 107 is wired by a connection connector 108. .
[0032]
As shown in FIG. 3, the pair of injection heads 110 are attached to the upper end of the caster stand 111 by a movable arm 112, and two chemical syringes 200 are detachably attached to the upper surface of each head body 113. Two rows of semi-cylindrical recesses 114 to be mounted individually are formed.
[0033]
A deformed portion 115 that detachably holds the cylinder flange 211 of the chemical syringe 200 is formed in the front portion of the recess 114, and a syringe drive that holds and slides the piston flange 221 behind the recess 114. A mechanism 116 is arranged.
[0034]
The syringe drive mechanism 116 has an ultrasonic motor (not shown) that does not generate a magnetic field as a drive source, and this ultrasonic motor includes a phosphor bronze alloy (Cu + Sn + P), a titanium alloy (Ti-6Al-4V), It is made of a nonmagnetic material such as a magnesium alloy (Mg + Al + Zn).
[0035]
In the liquid injector 100 of this embodiment, since each of the pair of injection heads 110 includes the two concave portions 114 and the syringe drive mechanism 116 as described above, the contrast injection mechanism 121, the saline injection mechanism 122, and the load injection mechanism are included here. 123 and the neutralization injection mechanism 124 are formed.
[0036]
The contrast injection mechanism 121 drives the drug solution syringe 200 filled with the contrast agent, and the saline injection mechanism 122 drives the drug solution syringe 200 filled with physiological saline. The load injection mechanism 123 drives the chemical syringe 200 filled with the myocardial loading drug, and the neutralization injection mechanism 124 drives the chemical syringe 200 filled with the neutralizing agent.
[0037]
In the chemical solution injection system 1000 of this embodiment, since various sizes of the chemical solution syringe 200 are prepared, only the maximum size chemical solution syringe 200 is directly attached to the recess 114 of the injection head 110 as shown in FIG. The chemical syringes 200 of sizes other than the maximum are attached to each via a dedicated cylinder adapter 230.
[0038]
As shown in FIG. 1, the chemical injection device 100 of this embodiment is connected to a computer unit 120 and performs integrated control of each unit corresponding to a computer program in which the computer unit 120 is installed. Similarly, in the MRI apparatus 300, the imaging control unit 302 includes a computer unit, and controls the operation of the fluoroscopic imaging unit 301 in accordance with a computer program in which the imaging control unit 302 is mounted.
[0039]
Further, in the fluoroscopic imaging system 1000 of the present embodiment, the computer unit 120 of the chemical injection device 100 and the imaging control unit 302 of the MRI apparatus 300 mutually communicate various data, and coordinately control the various operations. For this reason, the computer unit 120 of the chemical solution injector 100 functions as various means such as an injection transmitter, an injection receiver, and an injection controller, and the imaging control unit 302 of the MRI apparatus 300 includes an imaging transmitter and an imaging receiver. It functions as various means such as an imaging control means.
[0040]
More specifically, the chemical injection device 100 performs integrated control of the various injection mechanisms 121 to 124 in response to setting data input by the computer unit 120, and performs MRI of various data corresponding to the operation state. It transmits to the imaging control unit 302 of the apparatus 300.
[0041]
On the other hand, in the MRI apparatus 300, the operation of the fluoroscopic imaging unit 301 is controlled in accordance with the setting data input by the imaging control unit 302, and various data corresponding to the operating state are stored in the computer unit 120 of the chemical injection device 100. Send to.
[0042]
Further, in the liquid injector 100, the computer unit 120 receives various data from the imaging control unit 302 of the MRI apparatus 300, and integrally controls the various injection mechanisms 121 to 124 corresponding to the various received data. Similarly, in the MRI apparatus 300, the imaging control unit 302 receives various data from the computer unit 120 of the chemical solution injector 100, and controls the operation of the fluoroscopic imaging unit 301 corresponding to the various received data.
[0043]
In the fluoroscopic imaging system 1000 of the present embodiment, the medicinal solution injection device 100 and the MRI apparatus 300 operate in cooperation as described above, and as a result, as shown in FIG. The contrast medium injection is performed by the contrast injection mechanism 121 from one minute before the completion to one minute. Simultaneously with the completion of the injection of the contrast medium, saline injection is performed for up to 1 minute by the saline injection mechanism 122, and at the same time as the injection of the physiological saline and the myocardial loading drug is completed, the fluoroscopic imaging unit 301 loads the fluoroscopic image. The imaging is performed for several tens of seconds.
[0044]
Simultaneously with the completion of this imaging, the neutralization injection mechanism 124 performs the injection of the neutralizing agent for up to 1 minute. When a predetermined time of about one and a half minutes has elapsed since the completion of the injection of the neutralizing agent, the contrast injection mechanism 121 Infusion is performed for up to 1 minute. Simultaneously with the completion of the injection of the contrast medium, saline injection is performed for up to 1 minute by the saline injection mechanism 122, and at the same time as the injection of the physiological saline is completed, the fluoroscopic imaging unit 301 captures a resting fluoroscopic image by several tens. Run up to seconds.
[0045]
Note that the various means of the chemical liquid injector 100 and the MRI apparatus 300 as described above are realized by using hardware such as the touch panel 104 as necessary, but the main unit is mounted by the computer unit 120 and the imaging control unit 302. This is realized by executing various operations corresponding to the computer program being executed.
[0046]
Such a computer program, for example, first executes the injection of the myocardial loading drug for up to 6 minutes by the load injection mechanism 123, and executes the injection of the contrast agent by the contrast injection mechanism 121 from 2 minutes before the completion to 1 minute. Simultaneously with the completion of the injection of the contrast medium, the saline injection mechanism 122 executes the injection of physiological saline for up to one minute. Simultaneously with the completion of the injection of the physiological saline and the myocardial loading drug, the fluoroscopic imaging unit 301 loads. The imaging of the fluoroscopic image of the state is executed up to several tens of seconds, the neutralization injection mechanism 124 performs the injection of the neutralizing agent for up to 1 minute simultaneously with the completion of the imaging, and the time of 1 minute and a half from the completion of the injection of the neutralizing agent When the predetermined time has passed, the contrast injection mechanism 121 executes the injection of the contrast medium for up to 1 minute, and at the same time as the injection of the contrast medium is completed, the saline injection mechanism 122 performs the physiological saline. The computer unit is configured to execute a processing operation such as performing on-off for up to 1 minute, simultaneously performing completion of physiological saline injection, and performing imaging of a resting fluoroscopic image for several tens of seconds with the fluoroscopic imaging unit 301. 120 is implemented by firmware or the like.
[0047]
[Operation of the embodiment]
In the above-described configuration, in the chemical injection system 1000 according to the present embodiment, a myocardial load medicine or a contrast agent is injected into the subject with the chemical injection device 100, and a fluoroscopic image is captured from the subject with the MRI apparatus 300. It is possible to capture fluoroscopic images of a load state in which a load is applied to the subject's myocardium and a rest state in which no load is applied.
[0048]
In this case, the operator places the subject on the fluoroscopic imaging unit 301 of the MRI apparatus 300, and prepares the drug solution syringes 200 of the contrast medium, the physiological saline, the myocardial loading drug, and the neutralizing agent, respectively. And these four chemical | medical solution syringes 200 are suitably connected with a test subject with an extension tube (not shown) etc., and are loaded in the four injection | pouring mechanisms 121-124 of the chemical | medical solution injection apparatus 100 individually.
[0049]
In this state, for example, when the operator inputs an operation start to the operation panel 103 of the chemical liquid injector 100, the chemical injector 100 that detects this is started (step S1) as shown in FIG. Is transmitted to the MRI apparatus 300 (step S2).
[0050]
Then, when the start of work is returned from the MRI apparatus 300 in response to the above data transmission (step S3), the chemical injection device 100 starts a series of work (step S9 ~), but the start of work is data If not received or if error guidance data is received (step S3), error guidance such as “XX error. Please check the MRI device” is output on the touch panel 104 or the speaker unit 105 to the initial state. Return (step S7).
[0051]
Note that the MRI apparatus 300 receives the work start data from the chemical injection device 100 as described above as shown in FIG. 8 in a state where the operation start is not input to the imaging control unit 302 (step T4). The self state is diagnosed (step T5), and if no error is detected by this, the work start is returned to the chemical injection device 100 (step T8).
[0052]
In addition, when an error is detected by the above self-diagnosis (step T5), the MRI apparatus 300 returns an error guidance to the liquid injector 100 (step T6) and confirms “XX error. An error guidance such as “Please” is informed and returned to the initial state (step T7).
[0053]
Also, when the operator first inputs an operation start to the MRI apparatus 300 instead of the chemical injection apparatus 100, as shown in FIGS. 8 and 6, the MRI apparatus 300 and the chemical injection apparatus 100 are the same as described above. The start of work is mutually confirmed by mutual communication (steps T1 to T3, S4 to S8).
Then, as shown in FIG. 6, the drug solution injection device 100 that confirms the start of the operation first activates the load injection mechanism 123 to start injection of the myocardial load drug into the subject (step S <b> 9), and is shown in FIG. 5. Thus, when 4 minutes have elapsed from the start of injection (step S10), the contrast injection mechanism 121 is operated to start injection of contrast medium (step S11).
[0054]
When one minute has elapsed from the start of the injection (step S12), the contrast injection mechanism 121 is stopped and the contrast medium injection is completed, and the saline injection mechanism 122 is activated to start the injection of physiological saline ( Step S13). Then, when 1 minute has passed since the start of the injection (step S14), the load injection mechanism 123 and the saline injection mechanism 122 are stopped, and the injection of the myocardial load medicine and the physiological saline is completed (step S15).
[0055]
Then, the medicinal solution injection device 100 transmits data of the completion of injection to the MRI apparatus 300 (step S16). As shown in FIG. 8, the MRI apparatus 300 that has received the data of completion of injection (step T9) A fluoroscopic image in a loaded state is taken from a subject who has been injected with a contrast agent (step T10).
[0056]
When the imaging in this load state is completed (step T11), the MRI apparatus 300 transmits imaging completion data to the chemical injection device 100 (step T12), and therefore, as shown in FIG. The apparatus 100 (step S17) operates the neutralization injection mechanism 124 to start injection of the neutralizing agent into the subject (step S18), and when 1 minute has elapsed from the start of injection as shown in FIG. In step S19), the neutralization injection mechanism 124 is stopped to complete the injection of the neutralizing agent (step S20).
[0057]
When a predetermined waiting time elapses from the completion of the injection (step S21), the contrast injection mechanism 121 is operated and the injection of the contrast agent is started again (step S22). When one minute has elapsed from the start of injection (step S23), the contrast injection mechanism 121 is stopped and the contrast medium injection is completed again, and the saline injection mechanism 122 is operated to start the physiological saline injection again. (Step S24).
[0058]
Then, when 1 minute has elapsed from the start of the injection (step S24), the saline injection mechanism 122 is stopped and the injection of physiological saline is completed again (step S25). Then, since the chemical injection device 100 transmits data of the completion of the second injection to the MRI apparatus 300 (step S26), as shown in FIG. 8, the MRI apparatus 300 that has received the data of the completion of the second injection (step T13) A fluoroscopic image in a resting state is taken from the subject into which the myocardial stress drug is neutralized and the contrast medium is injected (steps T14 and T15).
[0059]
[Effect of the embodiment]
In the chemical injection system 1000 according to the present embodiment, as described above, the chemical injection device 100 and the MRI apparatus 300 mutually communicate various data, and the chemical injection and imaging are controlled in accordance with the communication data. . For this reason, since injection of various chemicals and imaging of fluoroscopic images can be integratedly controlled, a series of imaging of fluoroscopic images at appropriate timing by individually injecting myocardial loading drugs and contrast agents into the subject at appropriate timings This work can be properly executed even by one worker.
[0060]
Moreover, in the chemical injection system 1000 of this embodiment, since the chemical injection device 100 can also inject a neutralizing agent into the subject, the myocardial loading drug is injected into the subject and a fluoroscopic image of the loaded state is taken. It is possible to immediately take a fluoroscopic image in a resting state by injecting a Japanese medicine. Furthermore, since the liquid injector 100 can inject physiological saline into the subject, the contrast medium to be injected into the affected area of the subject can be minimized, and the running cost can be reduced and the physical burden on the subject can be reduced. can do.
[0061]
In particular, in the drug solution injection system 1000 of this embodiment, not only the myocardial stress drug and contrast agent but also the neutralizing agent and physiological saline can be injected into the subject as described above, but all the injections can be managed appropriately. Therefore, an extremely complicated series of operations can be automatically executed.
[0062]
Furthermore, in the chemical injection system 1000 of this embodiment, the drive source of the chemical injection device 100 is formed of a non-magnetic material and includes an ultrasonic motor that does not generate a magnetic field. Therefore, the chemical injection device 100 is problematic in the vicinity of the MRI apparatus 300. It can be used without.
[0063]
[Modification of Embodiment]
The present invention is not limited to the present embodiment, and various modifications are allowed without departing from the scope of the present invention. For example, in the above embodiment, it is assumed that the chemical injection device 100 is used in the vicinity of the MRI apparatus 300, but this can also be used in the vicinity of a CT scanner, an angio apparatus, an ultrasonic diagnostic apparatus, or the like.
[0064]
Moreover, although the chemical | medical solution injection apparatus 100 and the MRI apparatus 300 illustrated the mutual communication in the said form, it is also possible to make the communication direction into only one side. For example, when only data transmission is executed from the chemical injection device 100 to the MRI apparatus 300, it is preferable that the MRI apparatus 300 executes image capturing in conjunction with the injection operation of the chemical injection apparatus 100. In this case, since the chemical solution injection device 100 cannot directly confirm the completion of imaging by the MRI apparatus 300, it is preferable to execute the chemical solution injection in accordance with a preset time schedule.
[0065]
On the other hand, when only data transmission is performed from the MRI apparatus 300 to the chemical injection device 100, the MRI apparatus 300 transmits data of the start of work to the chemical injection device 100, so that the chemical injection device 100 corresponds to a preset time schedule. Thus, it is preferable to execute the chemical injection. In this case, since the MRI apparatus 300 cannot directly confirm the completion of the injection of the chemical solution injection apparatus 100, it is preferable that the MRI apparatus 300 also captures an image in accordance with a preset time schedule.
[0066]
Furthermore, in the above embodiment, it is exemplified that the myocardial loading drug is first injected into the subject and the loaded state is imaged, and then the neutralizing agent is injected and the resting state is imaged. It is also possible to make the injection of the neutralizing agent unnecessary by imaging the load state after imaging the resting state. In the above embodiment, it is exemplified that the volume of the contrast medium injected to the affected area is boosted with physiological saline, but as shown in FIG. 9, the contrast medium is not boosted with physiological saline. Can also be injected into the affected area.
[0067]
Furthermore, in the above embodiment, various means are logically realized as various functions of the chemical liquid injector 100 and the MRI apparatus 300 by operating corresponding to the computer program in which the computer unit 120 and the imaging control unit 302 are mounted. Exemplified that.
[0068]
However, each of these various means can be formed as unique hardware, and a part thereof can be implemented as software on the computer unit 120 or the imaging control unit 302, and a part can be formed as hardware. Is possible.
[0069]
【The invention's effect】
In the first fluoroscopic imaging system of the present invention, the medicinal solution injecting device and the fluoroscopic imaging device mutually communicate various data, and the medicinal solution injecting and the imaging are respectively controlled in accordance with the communication data, whereby the myocardial load is controlled. Since the injection of the medicine and contrast agent and the imaging of the fluoroscopic image can be integratedly controlled, the myocardial loading drug and the contrast agent are individually injected into the subject at an appropriate timing, and then the fluoroscopic image is taken at the appropriate timing. Even a single worker can appropriately execute a series of operations.
[0070]
In the second fluoroscopic imaging system of the present invention, the medicinal solution injection device transmits various data to the fluoroscopic imaging device, and the imaging is controlled in accordance with the communication data, whereby the myocardial loading drug and the contrast agent are injected. The imaging of fluoroscopic images can be controlled in response to the situation, so that a series of operations to inject fluoroscopic images at the appropriate timing after injecting myocardial loading drugs and contrast agents individually into the subject at appropriate timing Even one person can perform appropriately.
[0071]
In the third fluoroscopic imaging system of the present invention, the fluoroscopic imaging device transmits various data to the chemical liquid injector, and the injection of the myocardial load medicine and the contrast agent is controlled by controlling the chemical liquid injection corresponding to the communication data. Can be controlled in accordance with fluoroscopic imaging, so that a myocardial stress drug and a contrast agent are individually injected into a subject at an appropriate timing, and then a series of operations are performed to capture fluoroscopic images at an appropriate timing. Even one person can perform appropriately.
[Brief description of the drawings]
FIG. 1 is a block diagram showing a circuit structure of a fluoroscopic imaging system according to an embodiment of the present invention.
FIG. 2 is a perspective view showing an appearance of a fluoroscopic imaging system.
FIG. 3 is a perspective view showing an appearance of a chemical liquid injector.
FIG. 4 is a perspective view showing a state where a chemical syringe is attached to an injection head of the chemical injection device.
FIG. 5 is a time chart showing a fluoroscopic imaging method by the fluoroscopic imaging system.
FIG. 6 is a flowchart showing the first half of the processing operation of the chemical liquid injector.
FIG. 7 is a flowchart showing a second half part.
FIG. 8 is a flowchart showing a processing operation of the MRI apparatus.
FIG. 9 is a time chart illustrating a fluoroscopic imaging method according to a modification.
[Explanation of symbols]
100 chemical injection device
120 Computer units that function as various means
121 Contrast injection mechanism
122 Saline injection mechanism
123 Load injection mechanism
124 Neutralization injection mechanism
300 MRI apparatus which is a fluoroscopic imaging apparatus
301 perspective imaging unit
302 Imaging control unit that functions as various means

Claims

A fluoroscopic imaging device that captures a fluoroscopic image of the subject, and a chemical liquid injector that injects a chemical into the subject to be imaged,
The medicinal solution injecting apparatus includes a load injecting mechanism that injects a myocardial loading agent that applies a load to the myocardium of the subject as the medicinal solution into the subject, and a contrast medium that injects the contrast agent that contrasts the fluoroscopic image as the medicinal solution into the subject. Injection mechanism, injection transmission means for transmitting various data corresponding to the operating state of at least the load injection mechanism and the contrast injection mechanism to the fluoroscopic imaging device, and injection receiving means for receiving various data from the fluoroscopic imaging device And an injection control means for integrally controlling the load injection mechanism and the contrast injection mechanism corresponding to various received data,
The fluoroscopic imaging device includes: an imaging unit that captures the fluoroscopic image; an imaging transmission unit that transmits at least various data corresponding to an operation state of the imaging unit to the chemical injection device; and various types from the chemical injection device. A fluoroscopic imaging system comprising: an imaging receiving unit that receives data; and an imaging control unit that controls the operation of the image imaging unit in response to various types of received data.

A fluoroscopic imaging device that captures a fluoroscopic image of the subject, and a chemical liquid injector that injects a chemical into the subject to be imaged,
The medicinal solution injecting apparatus includes a load injecting mechanism that injects a myocardial loading agent that applies a load to the myocardium of the subject as the medicinal solution into the subject, and a contrast medium that injects the contrast agent that contrasts the fluoroscopic image as the medicinal solution into the subject. An injection mechanism, and injection transmission means for transmitting at least various data corresponding to operation states of the load injection mechanism and the contrast injection mechanism to the fluoroscopic imaging device,
The fluoroscopic imaging device includes an imaging unit that captures the fluoroscopic image, an imaging receiving unit that receives various data from the chemical injection device, and an imaging control that controls the operation of the image imaging unit in response to the various types of received data. And a fluoroscopic imaging system.

A fluoroscopic imaging device that captures a fluoroscopic image of the subject, and a chemical liquid injector that injects a chemical into the subject to be imaged,
The medicinal solution injecting apparatus includes a load injecting mechanism that injects a myocardial loading agent that applies a load to the myocardium of the subject as the medicinal solution into the subject, and a contrast medium that injects the contrast agent that contrasts the fluoroscopic image as the medicinal solution into the subject. An injection mechanism, injection receiving means for receiving various data from the fluoroscopic imaging device, and injection control means for integrally controlling the load injection mechanism and the contrast injection mechanism corresponding to the various received data. And
The fluoroscopic imaging device includes an imaging imaging unit that captures the fluoroscopic image, and an imaging transmission unit that transmits at least various data corresponding to an operation state of the imaging unit to the chemical injection device. Imaging system.

The load injection mechanism first performs injection of the myocardial load drug,
The contrast injection mechanism performs the injection of the contrast agent immediately before the completion of the injection of the myocardial loading drug,
The fluoroscopic imaging system according to any one of claims 1 to 3, wherein the imaging unit starts imaging the fluoroscopic image before and after completion of the injection of the contrast agent.

The medicinal solution injecting apparatus also has a neutralization injecting mechanism for injecting the subject as a medicinal solution with a neutralizing agent that neutralizes the myocardial stress drug,
The neutralization injection mechanism starts injection of the neutralizing agent before and after the completion of imaging of the fluoroscopic image,
The contrast injection mechanism performs the injection of the contrast agent again after a predetermined time has elapsed from the completion of the injection of the neutralizing agent,
The fluoroscopic imaging system according to claim 4, wherein the imaging unit restarts imaging of the fluoroscopic image before and after completion of reinjection of the contrast agent.

The contrast injection mechanism first performs injection of the contrast agent,
The image capturing means starts capturing the fluoroscopic image before and after the completion of the injection of the contrast agent,
The load injection mechanism performs injection of the myocardial load drug after the imaging of the fluoroscopic image is completed,
The contrast injection mechanism performs injection of the contrast agent again immediately before completion of injection of the myocardial loading drug,
The fluoroscopic imaging system according to any one of claims 1 to 3, wherein the imaging unit restarts imaging of the fluoroscopic image before and after completion of reinjection of the contrast agent.

The chemical solution injection device also has a saline injection mechanism for injecting physiological saline into the subject as the chemical solution,
The fluoroscopic imaging system according to any one of claims 4 to 6, wherein the saline eating mechanism performs the injection of the physiological saline before and after the completion of the injection of the contrast medium.

A fluoroscopic imaging method using the fluoroscopic imaging system according to claim 4,
First, the load injection mechanism performs injection of the myocardial load drug,
Immediately before the completion of the injection of the myocardial loading drug, the contrast injection mechanism performs the injection of the contrast agent,
A fluoroscopic imaging method for causing the image imaging means to start imaging the fluoroscopic image before and after completion of injection of the contrast agent.

A fluoroscopic imaging method using the fluoroscopic imaging system according to claim 5,
First, the load injection mechanism performs injection of the myocardial load drug,
Immediately before the completion of the injection of the myocardial loading drug, the contrast injection mechanism performs the injection of the contrast agent,
Before and after the completion of the injection of the contrast agent, the imaging means starts imaging of the fluoroscopic image,
Before and after the completion of imaging of the fluoroscopic image, the neutralization injection mechanism starts injection of the neutralizing agent,
When a predetermined time has elapsed from the completion of the injection of the neutralizing agent, the contrast injection mechanism is made to execute the injection of the contrast agent again,
A fluoroscopic imaging method for causing the image imaging means to start imaging the fluoroscopic image again before and after the completion of reinjection of the contrast agent.

A fluoroscopic imaging method using the fluoroscopic imaging system according to claim 6,
First, the contrast injection mechanism performs injection of the contrast agent,
Before and after the completion of the injection of the contrast agent, the imaging means starts imaging of the fluoroscopic image,
After the imaging of the fluoroscopic image is completed, the load injection mechanism performs injection of the myocardial load medicine,
Immediately before the completion of the injection of the myocardial load medicine, the contrast injection mechanism performs the injection of the contrast agent again,
A fluoroscopic imaging method for causing the image imaging means to start imaging the fluoroscopic image again before and after the completion of reinjection of the contrast agent.

A computer program for injection control means and retransmission control means of the fluoroscopic imaging system according to claim 4,
First causing the load injection mechanism to perform injection of the myocardial load drug;
Causing the contrast injection mechanism to execute the injection of the contrast agent immediately before the completion of the injection of the myocardial load medicine,
Causing the image capturing means to start capturing the fluoroscopic image before and after the completion of the injection of the contrast agent;
A computer program for causing the injection control means and the retransmission control means to execute.

A computer program for injection control means and retransmission control means of the fluoroscopic imaging system according to claim 5,
First causing the load injection mechanism to perform injection of the myocardial load drug;
Causing the contrast injection mechanism to execute the injection of the contrast agent immediately before the completion of the injection of the myocardial load medicine,
Causing the image capturing means to start capturing the fluoroscopic image before and after the completion of the injection of the contrast agent;
Starting injection of the neutralizing agent into the neutralization injection mechanism before and after completion of imaging of the fluoroscopic image,
Causing the contrast injection mechanism to re-inject the contrast agent after a predetermined time has elapsed since the completion of the neutralization agent injection;
Causing the imaging device to start imaging the fluoroscopic image again before and after the completion of reinjection of the contrast agent;
A computer program for causing the injection control means and the retransmission control means to execute.

A computer program for injection control means and retransmission control means of the fluoroscopic imaging system according to claim 6,
First causing the contrast injection mechanism to inject the contrast agent;
Causing the image capturing means to start capturing the fluoroscopic image before and after the completion of the injection of the contrast agent;
Causing the load injection mechanism to perform injection of the myocardial load medicine after the imaging of the fluoroscopic image is completed,
Causing the contrast injection mechanism to execute the injection of the contrast agent again immediately before the completion of the injection of the myocardial load medicine,
Causing the imaging device to start imaging the fluoroscopic image again before and after the completion of reinjection of the contrast agent;
A computer program for causing the injection control means and the retransmission control means to execute.

An information storage medium storing a computer program for the fluoroscopic imaging system according to any one of claims 4 to 6,
An information storage medium in which the computer program according to any one of claims 11 to 13 is stored.