JP2005017280A - Disposable pipet and blood collector - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a relatively inexpensive disposable pipet and a blood collector that can easily and accurately collect specified amount of blood, or the like, and can prevent bubbles from being mixed. <P>SOLUTION: In the disposable pipet in which a pipet cylinder communicates with a flexible cap, a temporary liquid absorbing device that can temporarily absorb liquid and can discharge the absorbed liquid by compressing or spraying gas is mounted into the pipet cylinder. An air permeable filter is mounted between the temporary liquid absorbing device and the cap. A check valve having an opening mechanism is mounted between the tip of the pipet cylinder and the temporary liquid absorbing device. Only the movement of liquid from the tip of the pipet cylinder toward the temporary liquid absorbing device is enabled normally. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to disposable pipettes and blood collection devices. In particular, the present invention relates to a disposable pipette and blood collection device used for testing blood, body fluid, and urine (hereinafter referred to as “blood”), and to a disposable pipette and blood collection device used for collecting a certain amount of blood.

FIG. 2 is a schematic view of a conventional disposable pipette. The conventional disposable pipette 11 has a dropper tube 11a and a bellows-shaped cap 11b connected to each other, and no filter for blocking the passage of blood or the like is attached to the dropper tube 11a. The dropper cylinder 11a and the cap 11b are both made of a transparent or translucent material having flexibility. The dropper cylinder 11a is provided with marks 11c and 11d. The mark 11c indicates the lower limit of the amount of blood or the like to be collected, and the mark 11d indicates the upper limit of the amount of blood or the like to be collected. The tip of the dropper cylinder 11a is open, but has the same outer diameter and inner diameter as the other parts, and is narrow.

  However, it is difficult to match blood or the like between the mark 11c and the mark 11d, and a predetermined amount of blood or the like cannot be collected unless the blood and the like are repeatedly collected and discharged.

  In addition, bubbles are likely to be mixed into blood or the like in the pipette. While holding the dropper tube 5 with one hand, the tip of the dropper tube is put into blood or the like, and blood or the like is collected into the dropper tube by capillary action. However, it is often accidentally operated by pushing and releasing the cap with the thumb, and air is sucked in. It is difficult to remove the mixed bubbles with a conventional pipette. As a result, blood must be collected and discharged many times. In addition, the amount of collected blood is insufficient for blood or the like mixed with bubbles, or an accurate inspection cannot be performed.

  SUMMARY OF THE INVENTION An object of the present invention is to provide a disposable pipette and blood collecting device that can easily and accurately collect a predetermined amount of blood and the like and that does not contain bubbles and is relatively inexpensive.

  In the disposable pipette according to the first aspect of the present invention, that is, the disposable pipette in which the dropper tube and the flexible cap communicate with each other, the liquid can be temporarily sucked and compressed. A temporary liquid absorption that can release the liquid that is absorbed by blowing gas or by blowing a gas is installed in the syringe cylinder, an air-permeable filter is installed between the temporary liquid absorption and the cap, and the syringe cylinder This is achieved by a disposable pipette that is fitted with a check valve with an opening mechanism between the tip of the tube and the temporarily sucked liquid, and usually allows only movement of the liquid from the tip of the dropper tube toward the temporarily sucked liquid.

  In a preferred embodiment of the disposable pipette according to the present invention, as described in claim 2, the tip of the dropper cylinder is composed of a suction port part having a through inner tube, and is movable toward the cap. If the cap part of the mouth part is a small diameter nozzle and the suction part is pushed in and moved toward the cap, the nozzle is inserted into the check valve with an opening mechanism and the check valve is opened.

  Moreover, in another preferable embodiment of the disposable pipette according to the present invention, as described in claim 3, a temporary suction liquid compression pin for compressing the temporary suction liquid from the cap or blowing air is provided. .

  Further, the above object is to provide a disposable blood collecting device according to the present invention as set forth in claim 4, that is, a liquid-absorbing liquid containing a blood coagulation-preventing liquid, and a liquid-absorbing liquid that temporarily absorbs a predetermined amount of blood at the tip. In addition, this can be achieved by a disposable blood collecting device provided with a pressing body that pushes the rear surface of the liquid absorption to separate the liquid absorption.

  In a preferred embodiment of the disposable blood collecting device according to the present invention, as described in claim 5, the disposable blood collecting device has a lock means capable of releasing the movement prevention of the pressing body.

  The disposable pipette and blood collection device according to the present invention has a temporary liquid absorption or liquid absorption attached to the inside of the dropper cylinder or the tip of the main body, so that a predetermined amount (for example, 50 μl, 60 μl) of blood or the like is accurately and easily collected, In addition, an effect that a predetermined amount of blood or the like can be accurately and easily transferred to a test container or the like can be obtained.

In addition, since the disposable pipette according to the present invention has a check valve with an opening mechanism installed in the dropper cylinder, blood or the like flows only from the suction port toward the temporary suction liquid when blood or the like is collected, but does not flow backward. When transferring to a test container or the like, the check valve with an opening mechanism can be opened to move blood or the like absorbed by the temporary liquid absorption toward the suction port. Therefore, there is an effect that the procedure for collecting blood and the like and transferring it to a test container can be easily performed by any number of people.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

First Embodiment FIG. 1 is a front sectional view of a disposable pipette according to a first embodiment of the present invention.

  The suction port component 1 has a slightly thin outer diameter at the tip 1a, the central portion 1c has a substantially constant outer diameter, a slight circumferential projection, and the other end has a thin outer diameter and a constant outer diameter. 1b is integrally formed. Inside the suction port component 1, a linear inner tube 1d having a constant inner diameter is formed. The suction port component 1 is preferably made of a slightly elastic material such as hard plastic or hard rubber. The inner tube 1d may be coated with silicone and Teflon (registered trademark), and then an anticoagulant such as heparin may be applied. The suction port component 1 may be transparent, translucent, or opaque.

The first holder 2 is integrally made of a transparent or translucent hard plastic and has a slight elasticity. A portion having a thin outer diameter and a portion having a large outer diameter are connected in the axial direction with a common central axis. The end of the portion with the thin outer diameter is the suction port part mounting / guide portion 2a, and the first position recess 2b and the second position recess 2c are formed on the inner surface. A check valve mounting portion 2 d is also provided at a portion where the outer diameter of the first holder 2 is thick, and a check valve 3 is mounted inside by a check valve holder 4. The end of the portion with the thick outer diameter is a joining portion 2f for joining with the second holder, and one circumferential recess 2g that is slightly recessed is formed on the inner surface. There is a temporary liquid-absorbing attachment portion 2e inside the portion having a large outer diameter, and a knob portion 2i outside the portion. A columnar temporary liquid absorption 5 infiltrated with an anticoagulant such as heparin is attached in the temporary liquid absorption portion 2e. As the temporary liquid absorption, a cigarette filter, a water absorption filter used as a pen tip of a marker pen, or the like can be used. By managing the shape and dimensions of the temporary liquid absorption 5, 50 μl or 60 μl of blood or the like can be collected and stored easily with good reproducibility with little variation. The inside of the first holder 2 includes an inner surface for guide of the suction port part mounting / guide portion 2a, an inner surface of the check valve mounting portion 2d, a connecting thin tube portion 2j, and an inner surface of the temporary liquid suction mounting portion 2e. Although communicated, each inner diameter is different. An abutting surface 2h is formed at the boundary between the check valve mounting portion 2d and the connecting thin tube portion 2j.

  The second holder 6 is integrally made of a slightly elastic plastic. Engaging protrusions 6a are formed on the outer surface of the first holder joint portion substantially over the circumference. The other end is a cap joint 6b having a relatively small diameter, and the inside thereof is a cylindrical guide surface 6c.

  The cap 8 is made of flexible elastic rubber or the like. It consists of a cylindrical mounting portion 8a, a pressing portion 8b, and a bottom portion 8c. The bottom portion 8c is formed with a through hole through which the filter compression pin 9 is inserted and a slight gap is formed around in the normal state.

  The filter compression pin 9 has a substantially hollow cylindrical shape, one end 9f is plugged with a push part 10, and the other end 9a is attached with an air-permeable filter 7. In addition, communication holes 9b, 9d, and 9e communicating with the side surfaces are formed near the other end 9a and at two central positions, respectively. The communication holes 9b have the same position in the central axis direction, and four communication holes are provided around the central axis by 90 °.

The check valve 3 has a “glass mouth” shape in which two flat plates come into contact with each other at their long sides and are made of a soft rubber material such as silicone rubber, synthetic rubber, or natural rubber. The liquid flowing from the suction port part 1 toward the temporary liquid 5 flows, but the reverse flow is blocked. The check valve may be a valve having a cut in the shape of a cross, “Y” shape, or “one” shape in the center of a flat circular shape.

  How to use the disposable pipette in the basic state will be described.

The tip of the suction port part 1 is kept immersed or in contact with blood or the like. Then, the knob portion 2i is sandwiched between the thumb and index finger of one hand, and the cap 8 is sandwiched and pressed between the thumb and index finger of the other hand. Then, a part of the air inside the cap 8 is discharged outside through a gap formed in the bottom portion 8c of the cap 8, and the cap 8 is recessed. Next, when the finger of the other hand is released, the cap 8 attempts to return to its original shape, the pressure inside the cap 8 decreases, and blood or the like passes from the tip of the suction port component 1 through the inner tube 1d. Sucked. Since the surface of the inner tube 1d is coated with silicone and Teflon (registered trademark) and further anticoagulant is applied, the sucked blood or the like is hard to condense and the surface tension with the surface of the inner tube 1d And blood etc. quickly flow along the inner tube 1d. Subsequently, blood or the like that has passed through the inner tube 1 d passes through the check valve 3, passes through the connecting thin tube portion 2 j, and reaches the temporary liquid absorption 5. It is desirable that the surface of the connecting thin tube portion 2j is coated with silicone and Teflon (registered trademark), and further, an anticoagulant such as heparin is applied. When blood or the like comes into contact with the temporarily absorbing liquid 5, the blood or the like is absorbed by the temporarily absorbing liquid 5 and the color of the temporarily absorbing liquid 5 changes. A predetermined amount of blood or the like is absorbed, and the entire temporary absorption liquid 5 is discolored (red if human blood is used), so that the blood cannot be absorbed any more. At this time, the amount of blood or the like absorbed in the temporary liquid absorption 5 is substantially constant depending on the shape and dimensions of the temporary liquid absorption 5. Therefore, no matter how many people collect 50 μl of blood or 60 μl of urine, it can be made almost constant with good reproducibility. Moreover, since the anti-coagulant such as heparin is infiltrated into the temporary liquid absorption 5, the absorbed blood or the like does not condense.

  Air, blood, and the like near the temporary liquid absorption 5 pass through the inner tube from the opening at the other end 9a of the filter compression pin 9 and the communication hole 9b near the other end 9a, and the communication hole near the center of the filter compression pin 9. The air is sucked into the cap 8 through 9d and 9e. Since the air permeable filter 7 is attached to the other end 9 a of the filter compression pin 9, air is sucked and passed, but blood or the like cannot pass through the air permeable filter 7. As a result, blood or the like does not enter the cap 8 or the filter compression pin 9.

  Next, the first procedure after collecting blood or the like will be described.

  FIG. 3 is a front sectional view of the disposable pipette of the embodiment after performing the first procedure. When the suction port component 1 is pushed in, the circumferential protrusion of the suction port component 1 engages with the second position recess 2c of the first holder 2 and the nozzle portion 1b is connected to the check valve 3 as shown in FIG. The check valve 3 is pushed open and opened, and the tip of the nozzle portion 1b comes into contact with and comes into close contact with the contact surface 2h. Then, fluid such as blood can flow without leaking from the temporary suction liquid 5 to the suction port part 1 on the way.

  Next, the second procedure after the first procedure will be described.

  FIG. 4 is a front sectional view of the disposable pipette of the embodiment after performing the second procedure. When the push component 10 inserted into one end 9f of the filter compression pin 9 is pushed in, the filter compression pin 9 is guided along the guide surface 6c inside the cap joint 6b and moves in the central axis direction. Then, the other end 9 a of the filter compression pin 9 comes into contact with the temporary liquid absorption 5 and compresses the temporary liquid absorption 5. Since the opening of the other end 9 a of the filter compression pin 9 is blocked by the air-permeable filter 7, blood or the like absorbed by the temporary liquid absorption 5 enters the inner tube of the filter compression pin 9. Instead, all blood or the like passes through the connecting thin tube portion 2j of the first holder 2 and the inner tube 1d of the suction port component 1 in order, and flows out from the tip 1a of the suction port component 1. That is, all of the blood or the like absorbed in the temporary liquid absorption 5 is squeezed out, and a predetermined amount (for example, 50 μl or 60 μl) of blood or the like is transferred from the tip 1a of the suction port component 1 to a test container (not shown).

  During these procedures (collection of blood and the like, the first procedure, and the second procedure), no bubbles are mixed into the blood and the like. Moreover, since these procedures can be easily and stably performed using both hands, even a beginner or an elderly person can perform it without difficulty.

  Since no blood or the like adheres to the cap 8 of the disposable pipette after the transfer of blood or the like, it can be disposed of as general waste. Blood or the like adheres to the air permeable filter 7 attached to the other end 9a of the filter compression pin 9, but when the filter compression pin 9 is pushed in, the communication hole 9b is closed by the guide surface 6c, and the cap 8 is When pressed, air is ejected from the air-permeable filter 7 at the other end 9a through the communication holes 9d and 9e of the filter compression pin 9 through the inner tube. Therefore, blood or the like adhering to the air-permeable filter is blown away and removed. If blood or the like coagulates and adheres, it becomes difficult to remove blood or the like by jetting air. Therefore, it is preferable that an anticoagulant such as heparin is soaked in the air-permeable filter in advance. Since the air-permeable filter 7 from which blood or the like has been removed may have bacteria or viruses attached thereto, it must be disposed of as medical waste, but no blood or the like is attached to the filter compression pin 9.

Second Embodiment FIGS. 5, 6 and 7 are schematic views of a blood collection device according to a second embodiment of the present invention. FIG. 5 is a sectional view showing a state before and during blood collection. FIG. 6 is a blood collection device. FIG. 7 is a cross-sectional view showing a state where the cap is pushed after FIG. 6 and the liquid absorption is pushed and separated.

  The distal end portion 21a of the main body 21 of the blood collection device according to the second embodiment has a tapered shape whose inner surface is cylindrical and whose outer surface has a diameter decreasing toward the end. The porous filter 31 is disposed so as to slightly protrude from the end. Lock keys 24 and 25 are symmetrically arranged at the center. The rear end portion 21c has a slightly large diameter cylindrical shape, and a push button portion 23 in which a cylindrical portion and a hemispherical shell portion are continuous is inserted therein. A pressing shaft portion 22 is connected to the pressing button portion 23, and the pressing shaft portion 22 is disposed inside the main body 21. The front end of the pressing shaft portion 22 is a pressing portion 22a. Key groove portions 22b and 22c are formed symmetrically in the central portion 21d, and are connected to the pressing button portion 23 at the rear end portion 22d. The lock keys 24 and 25 are made of a material having some flexibility such as resin or hard rubber including the engaging portions 24a and 25a, the fulcrum portions 24b and 25b, and the force point portions 24c and 25c, respectively. . Four small projections 21b for determining the position of the porous filter 31 are provided at 90 ° intervals around the central axis in the interior of the main body 21 near the tip 21a (see FIG. 5C). FIG. 5B is a cross-sectional view taken along the line AA ′ in FIG. 5A, but the end portions of the fulcrum portions 24 b and 25 b of the lock keys 24 and 25 are in contact with the side surfaces of the pressing shaft portion 22. 22 is guided so that it can move to its central axis. The engaging portions of the lock keys 24 and 25 are normally engaged with the groove portions 22b and 22c of the pressing shaft portion 22, and in this case, the pressing shaft portion 22 cannot move.

  The pressing portion 22 a of the pressing shaft portion 22 does not touch the porous filter 31. As the porous filter 31, a commercially available porous cylindrical body such as a product name “fiber rod” can be used, and a predetermined amount, for example, 50 μl, 60 μl, 70 μl, or 80 μl of blood is sucked using the capillary phenomenon. Adjust the length. In order to prevent blood coagulation, it is preferable to impregnate the porous filter 31 with an anticoagulant such as heparin in advance.

  It is very easy to suck a predetermined amount of blood using the blood collecting device in the state shown in FIG. Blood is drawn by inserting a needle or the like into the skin, and the blood is sucked by bringing the tip of the porous filter 31 of the blood collecting device of the second embodiment into contact with the blood. The contact is continued until the porous filter 31 no longer absorbs liquid. Then, a predetermined amount of blood can be collected in the porous filter 31 without mixing air. The air in the porous filter 31 is driven toward the other end and gradually released from the other end as blood is absorbed from the tip of the porous filter 31 by capillary action. As a result, a predetermined amount of 50 μl of blood is collected in the porous filter 31 without air mixing.

Next, as shown in FIG. 6, the blood collection device of the second embodiment is inserted into the blood collection bottle 32. Then, the inner surface of the bottle 32 comes into contact with the force point portions 24c and 25c of the lock keys 24 and 25, and the force point portions 24c and 25c are pushed and moved in the direction of the central axis as they are inserted. Then, the engaging portion 24a at the opposite position across the fulcrum portions 24b and 25b.
, 25a move away from the central axis. Then, the engagement between the engaging portions 24a and 25a of the lock keys 24 and 25 and the key groove portions 22b and 22c of the pressing shaft portion 22 is released. As a result, the pressing shaft portion 22 can freely move linearly along its central axis. In order to prevent rotational movement, it is preferable to provide a linear guide groove extending in parallel with the central axis on the inner surface of the main body 21.

  The blood collection bottle 32 has a bottom 32b. The drug solution is stored inside, storing blood and separating plasma and blood cells.

  Subsequently, as shown in FIG. 7, the push button part 23 is pushed in with a finger or the like. Then, the pressing portion 22 a of the pressing shaft portion 22 contacts and pushes the porous filter 31, pushes out the porous filter 31, separates the porous filter 31 from the distal end portion 21 a of the main body 21, and falls into the blood collection bottle 32. .

  It is preferable that the leg 32c of the blood collection bottle 32 has a shape and a structure that can stably stand upright.

  The distal end portion 21a of the main body 21 of the blood collection device is preferably transparent so that the presence or absence of the porous filter 31 can be visually confirmed and the liquid absorption state of blood into the porous filter 31 can be easily visually confirmed.

It is front sectional drawing of the disposable pipette of embodiment which concerns on this invention. It is the schematic of the conventional disposable pipette. It is front sectional drawing of the disposable pipette of embodiment after performing a 1st procedure. It is front sectional drawing of the disposable pipette of embodiment after performing a 2nd procedure. It is sectional drawing which shows the state before blood collection and during blood collection. It is sectional drawing which shows the state which inserted the blood collection device into the blood collection bottle. It is sectional drawing which shows the state which pushed the cap after FIG. 6 and pushed and separated the liquid absorption.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Suction port part 1a Tip 1b Nozzle part 1c Center part 1d Inner tube 2 First holder 2a Suction port part mounting / guide part 2b First position recess 2c Second position recess 2d Check valve mounting part 2e Temporary liquid absorption Mounting portion 2f Joint portion 2g Circumferential recess 2h Contact surface 2i Knob portion 2j Connection thin tube portion 3 Check valve 4 Check valve holder 5 Temporary liquid suction 6 Second holder 6a Engagement protrusion 6b Joining portion 6c Guide surface 7 Air passage Filter 8 cap 8a mounting portion 8b pressing portion 8c bottom 9 filter compression pin 9a other end 9b communication hole 9d communication hole 9e communication hole 9f one end 10 push part 11 pipette 11a dropper cylinder 11b cap 11c mark 11d mark 21 main body 21a tip 21b Small protrusion 21c Rear end portion 21d Center portion 22 Press shaft portion 22a Press portion 22b Groove portion 22c Groove portion 22d Rear end portion 3 push button portion 24 lock key 24a engaging portion 24b support point portion 24c power point portion 25 lock key 25a engaging portion 25b support point portion 25c power point portion 31 porous filter (liquid absorber)
32 Blood collection bottle 32b Bottom 32c Leg

Claims (5)

In a disposable pipette with a dropper tube and a flexible cap communicating with each other, it is possible to temporarily absorb the liquid and to release the liquid that is absorbed by compressing or blowing a gas. Attach the temporary suction liquid in the dropper cylinder, attach an air-permeable filter between the temporary suction liquid and the cap, and install a check valve with a release mechanism between the tip of the dropper cylinder and the temporary suction liquid. A disposable pipette that normally allows only movement of liquid from the tip of the tube toward the temporary liquid absorption. The tip of the dropper tube is made up of a suction port part with a penetrating inner tube and can be moved toward the cap. The cap side of the suction port part is a small diameter nozzle that pushes the suction port part toward the cap. The disposable pipette according to claim 1, wherein the nozzle is inserted into a check valve with an opening mechanism when the switch is moved to the open state. The disposable pipette according to claim 1 or 2, further comprising a temporary liquid absorption compression pin that compresses the temporary liquid absorption from the cap or blows air. A disposable blood collecting device including a blood-absorbing liquid containing a blood coagulation-preventing liquid, wherein a liquid-absorbing liquid that temporarily absorbs a predetermined amount of blood is disposed at a tip, and a pressing body that separates the liquid-absorbing liquid by pressing the rear surface of the liquid-absorbing liquid is provided. The disposable blood collecting device according to claim 4, further comprising lock means capable of releasing the prevention of movement of the pressing body.

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