JP2004537723A - ボルタンメトリーに用いるイオン選択性バイオセンサー - Google Patents
ボルタンメトリーに用いるイオン選択性バイオセンサー Download PDFInfo
- Publication number
- JP2004537723A JP2004537723A JP2003517560A JP2003517560A JP2004537723A JP 2004537723 A JP2004537723 A JP 2004537723A JP 2003517560 A JP2003517560 A JP 2003517560A JP 2003517560 A JP2003517560 A JP 2003517560A JP 2004537723 A JP2004537723 A JP 2004537723A
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- solid
- ions
- liquid
- support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004832 voltammetry Methods 0.000 title claims abstract description 7
- 239000007787 solid Substances 0.000 claims abstract description 64
- 150000002500 ions Chemical class 0.000 claims abstract description 56
- 238000000034 method Methods 0.000 claims abstract description 29
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 239000011248 coating agent Substances 0.000 claims abstract description 12
- 238000000576 coating method Methods 0.000 claims abstract description 12
- 238000009830 intercalation Methods 0.000 claims description 22
- 230000002441 reversible effect Effects 0.000 claims description 20
- FHCPAXDKURNIOZ-UHFFFAOYSA-N tetrathiafulvalene Chemical compound S1C=CSC1=C1SC=CS1 FHCPAXDKURNIOZ-UHFFFAOYSA-N 0.000 claims description 15
- 150000001768 cations Chemical class 0.000 claims description 14
- 239000012528 membrane Substances 0.000 claims description 10
- 150000001450 anions Chemical class 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 238000005259 measurement Methods 0.000 claims description 6
- 239000003014 ion exchange membrane Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 230000007717 exclusion Effects 0.000 claims 2
- PCCVSPMFGIFTHU-UHFFFAOYSA-N tetracyanoquinodimethane Chemical compound N#CC(C#N)=C1C=CC(=C(C#N)C#N)C=C1 PCCVSPMFGIFTHU-UHFFFAOYSA-N 0.000 claims 2
- 239000000243 solution Substances 0.000 description 16
- FGDZQCVHDSGLHJ-UHFFFAOYSA-M rubidium chloride Chemical compound [Cl-].[Rb+] FGDZQCVHDSGLHJ-UHFFFAOYSA-M 0.000 description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 7
- 230000002687 intercalation Effects 0.000 description 7
- -1 Ascorbate anions Chemical class 0.000 description 6
- 239000012491 analyte Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 229910021607 Silver chloride Inorganic materials 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 229920000557 Nafion® Polymers 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 238000007639 printing Methods 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical group CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 3
- HWCKGOZZJDHMNC-UHFFFAOYSA-M tetraethylammonium bromide Chemical compound [Br-].CC[N+](CC)(CC)CC HWCKGOZZJDHMNC-UHFFFAOYSA-M 0.000 description 3
- 238000001075 voltammogram Methods 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- HGOTVGUTJPNVDR-UHFFFAOYSA-N 2-(4,5-dimethyl-1,3-dithiol-2-ylidene)-4,5-dimethyl-1,3-dithiole Chemical compound S1C(C)=C(C)SC1=C1SC(C)=C(C)S1 HGOTVGUTJPNVDR-UHFFFAOYSA-N 0.000 description 2
- LZJCVNLYDXCIBG-UHFFFAOYSA-N 2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiine Chemical compound S1C(SCCS2)=C2SC1=C(S1)SC2=C1SCCS2 LZJCVNLYDXCIBG-UHFFFAOYSA-N 0.000 description 2
- YAHVGMRXXZDSOK-UHFFFAOYSA-N 5-([1,3]dithiolo[4,5-d][1,3]dithiol-5-ylidene)-[1,3]dithiolo[4,5-d][1,3]dithiole Chemical compound S1CSC(S2)=C1SC2=C(S1)SC2=C1SCS2 YAHVGMRXXZDSOK-UHFFFAOYSA-N 0.000 description 2
- 229920002799 BoPET Polymers 0.000 description 2
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 239000000370 acceptor Substances 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 239000003729 cation exchange resin Substances 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000004401 flow injection analysis Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 229910003472 fullerene Inorganic materials 0.000 description 2
- 229910021397 glassy carbon Inorganic materials 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 239000003456 ion exchange resin Substances 0.000 description 2
- 229920003303 ion-exchange polymer Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- YLGQLQSDQXOIBI-UHFFFAOYSA-N (29h,31h-phthalocyaninato(2-)-n29,n30,n31,n32)platinum Chemical compound [Pt+2].[N-]1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)[N-]3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 YLGQLQSDQXOIBI-UHFFFAOYSA-N 0.000 description 1
- RHPVRWXUCDJURW-UHFFFAOYSA-N (4-cyanoiminocyclohexa-2,5-dien-1-ylidene)cyanamide Chemical compound N#CN=C1C=CC(=NC#N)C=C1 RHPVRWXUCDJURW-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- OKIZCWYLBDKLSU-UHFFFAOYSA-M N,N,N-Trimethylmethanaminium chloride Chemical group [Cl-].C[N+](C)(C)C OKIZCWYLBDKLSU-UHFFFAOYSA-M 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 238000001016 Ostwald ripening Methods 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 150000001449 anionic compounds Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- LGODFJFAEWDETA-UHFFFAOYSA-N azulene-2,4,6,8-tetracarbonitrile Chemical compound C1=C(C#N)C=C(C#N)C2=CC(C#N)=CC2=C1C#N LGODFJFAEWDETA-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 239000012482 calibration solution Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- 230000005591 charge neutralization Effects 0.000 description 1
- 239000002801 charged material Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 150000003983 crown ethers Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002484 cyclic voltammetry Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 229910001412 inorganic anion Inorganic materials 0.000 description 1
- 239000002608 ionic liquid Substances 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 239000002555 ionophore Substances 0.000 description 1
- 230000000236 ionophoric effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 150000002891 organic anions Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000003057 platinum Chemical class 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000001524 potential step chrono-amperometry Methods 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
- 229940102127 rubidium chloride Drugs 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 150000003497 tellurium Chemical class 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- OSBSFAARYOCBHB-UHFFFAOYSA-N tetrapropylammonium Chemical compound CCC[N+](CCC)(CCC)CCC OSBSFAARYOCBHB-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0118931.5A GB0118931D0 (en) | 2001-08-02 | 2001-08-02 | Voltammetric ion-selective biosensor |
| PCT/GB2002/003569 WO2003012417A2 (en) | 2001-08-02 | 2002-08-02 | Voltammetric ion-selective biosensor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004537723A true JP2004537723A (ja) | 2004-12-16 |
| JP2004537723A5 JP2004537723A5 (enExample) | 2006-01-05 |
Family
ID=9919724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003517560A Pending JP2004537723A (ja) | 2001-08-02 | 2002-08-02 | ボルタンメトリーに用いるイオン選択性バイオセンサー |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040251133A1 (enExample) |
| EP (1) | EP1421374A2 (enExample) |
| JP (1) | JP2004537723A (enExample) |
| AU (1) | AU2002317998B2 (enExample) |
| GB (1) | GB0118931D0 (enExample) |
| WO (1) | WO2003012417A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060280721A1 (en) | 2003-06-03 | 2006-12-14 | The Gov Of Usa Represented By Secretary Of Dpt Of | Nutritional supplements and therapeutic compositions comprising (r)-3- hydroxybutyrate derivatives |
| GB0414548D0 (en) | 2004-06-29 | 2004-08-04 | Oxford Biosensors Ltd | Electrode preconditioning |
| GB0423025D0 (en) | 2004-10-15 | 2004-11-17 | Oxford Biosensors Ltd | Voltammetric ion sensor |
| US20090291844A1 (en) * | 2008-05-23 | 2009-11-26 | Lumimove, Inc. Dba Crosslink | Electroactivated film with immobilized peroxide activating catalyst |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| DK2914251T3 (da) | 2012-11-05 | 2019-11-04 | Us Health | Ketonlegemer til beskyttelse af væv mod beskadigelse som følge af ioniseringsstråling |
| GB201304467D0 (en) | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
| EP2984066B1 (en) | 2013-03-14 | 2017-02-01 | Oxford University Innovation Limited | Process for producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate |
| DE102016217261A1 (de) | 2016-09-09 | 2018-03-15 | Robert Bosch Gmbh | Selektive amperometrische Messung von nichtelektroaktiven Kationen und Einweg-Teststreifen |
| CN111989151B (zh) | 2018-01-15 | 2023-10-03 | Ddp特种电子材料美国有限责任公司 | 集成有限流器和传感器的螺旋卷式组件 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5841344A (ja) * | 1981-09-07 | 1983-03-10 | Baionikusu Kiki Kk | ボルタンメトリ−分析法 |
| JPS59500386A (ja) * | 1982-03-15 | 1984-03-08 | ラジオメ−タ・アクチセルスカベツト | イオン選択測定電極 |
| JPS59119254A (ja) * | 1982-12-25 | 1984-07-10 | Terumo Corp | イオン選択透過性・酸化還元機能性膜 |
| JPS61106620A (ja) * | 1984-10-31 | 1986-05-24 | Hitachi Ltd | 高分子金属錯体膜の形成方法 |
| GB2185821A (en) * | 1986-01-24 | 1987-07-29 | Cranfield Inst Of Technology T | Tetracyano-quinodimethane comprising electrochemical electrode |
| JPS6311846A (ja) * | 1986-02-27 | 1988-01-19 | クランフィールド バイオテクノロジー リミティド | 生電気化学的方法におけるテトラチアフルバレンの応用 |
| US5131999A (en) * | 1990-01-16 | 1992-07-21 | The National University Of Singapore | Voltammetric detector for flow analysis |
| JPH07140114A (ja) * | 1993-11-12 | 1995-06-02 | Akifumi Yamada | 塩分濃度計測用電極体 |
| WO2000031524A2 (de) * | 1998-11-19 | 2000-06-02 | F. Hoffmann-La Roche Ag | Elektrodensystem |
| WO2001042508A2 (en) * | 1999-12-09 | 2001-06-14 | Motorola, Inc. | Methods and compositions relating to electrical detection of nucleic acid reactions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2168815A (en) * | 1984-11-13 | 1986-06-25 | Genetics Int Inc | Bioelectrochemical assay electrode |
| CA1254945A (en) * | 1986-02-27 | 1989-05-30 | Marco F. Cardosi | Application of tetrathiafulvalenes in bioelectrochemical processes |
| US5312590A (en) * | 1989-04-24 | 1994-05-17 | National University Of Singapore | Amperometric sensor for single and multicomponent analysis |
| SU1728771A1 (ru) * | 1990-04-06 | 1992-04-23 | Институт биохимии АН ЛитССР | Способ определени тиолов |
| EP1269172B1 (en) * | 2000-03-01 | 2009-05-13 | Radiometer Medical ApS | Electrode device with a solid state reference system |
| US20030019748A1 (en) * | 2001-06-19 | 2003-01-30 | Elena Viltchinskaia | Method and apparatus for stripping voltammetric and potent iometric detection and measurement of contamination in liquids |
-
2001
- 2001-08-02 GB GBGB0118931.5A patent/GB0118931D0/en not_active Ceased
-
2002
- 2002-08-02 WO PCT/GB2002/003569 patent/WO2003012417A2/en not_active Ceased
- 2002-08-02 JP JP2003517560A patent/JP2004537723A/ja active Pending
- 2002-08-02 US US10/485,535 patent/US20040251133A1/en not_active Abandoned
- 2002-08-02 EP EP02747610A patent/EP1421374A2/en not_active Withdrawn
- 2002-08-02 AU AU2002317998A patent/AU2002317998B2/en not_active Ceased
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5841344A (ja) * | 1981-09-07 | 1983-03-10 | Baionikusu Kiki Kk | ボルタンメトリ−分析法 |
| JPS59500386A (ja) * | 1982-03-15 | 1984-03-08 | ラジオメ−タ・アクチセルスカベツト | イオン選択測定電極 |
| JPS59119254A (ja) * | 1982-12-25 | 1984-07-10 | Terumo Corp | イオン選択透過性・酸化還元機能性膜 |
| JPS61106620A (ja) * | 1984-10-31 | 1986-05-24 | Hitachi Ltd | 高分子金属錯体膜の形成方法 |
| GB2185821A (en) * | 1986-01-24 | 1987-07-29 | Cranfield Inst Of Technology T | Tetracyano-quinodimethane comprising electrochemical electrode |
| JPS6311846A (ja) * | 1986-02-27 | 1988-01-19 | クランフィールド バイオテクノロジー リミティド | 生電気化学的方法におけるテトラチアフルバレンの応用 |
| US5131999A (en) * | 1990-01-16 | 1992-07-21 | The National University Of Singapore | Voltammetric detector for flow analysis |
| JPH07140114A (ja) * | 1993-11-12 | 1995-06-02 | Akifumi Yamada | 塩分濃度計測用電極体 |
| WO2000031524A2 (de) * | 1998-11-19 | 2000-06-02 | F. Hoffmann-La Roche Ag | Elektrodensystem |
| JP2002530672A (ja) * | 1998-11-19 | 2002-09-17 | エフ．ホフマン−ラ ロシュ アーゲー | 電極系 |
| WO2001042508A2 (en) * | 1999-12-09 | 2001-06-14 | Motorola, Inc. | Methods and compositions relating to electrical detection of nucleic acid reactions |
Non-Patent Citations (1)
| Title |
|---|
| JPN7009003792, Ａｌａｎ Ｍ． Ｂｏｎｄ， Ｓｔｅｐｈｅｎ Ｆｌｅｔｃｈｅｒ ａｎｄ Ｐｅｔｅｒ Ｇ． Ｓｙｍｏｎｓ, "Ｔｈｅ ｒｅｌａｔｉｏｎｓｈｉｐ ｂｅｔｗｅｅｎ ｔｈｅ ｅｌｅｃｔｒｏｃｈｅｍｉｓｔｒｙ ａｎｄ ｔｈｅｃｒｙｓｔａｌｌｏｇｒａｐｈｙ ｏｆ ｍｉｃｒｏｃｒｙｓｔａｌｓ． Ｔｈｅ ｃａｓｅ ｏｆ Ｔ", Ｔｈｅ Ａｎａｌｙｓｔ, 1998, Ｖｏｌ．１２３, Ｐ．１８９１−１９０４, GB * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1421374A2 (en) | 2004-05-26 |
| GB0118931D0 (en) | 2001-09-26 |
| WO2003012417A3 (en) | 2004-03-18 |
| AU2002317998B2 (en) | 2007-07-05 |
| US20040251133A1 (en) | 2004-12-16 |
| WO2003012417A2 (en) | 2003-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhao et al. | Simultaneous detection of heavy metals by anodic stripping voltammetry using carbon nanotube thread | |
| Michalska | All‐Solid‐State Ion Selective and All‐Solid‐State Reference Electrodes | |
| Ding et al. | Solid reference electrode integrated with paper-based microfluidics for potentiometric ion sensing | |
| Adhikari et al. | Polymers in sensor applications | |
| Zuliani et al. | Opportunities and challenges of using ion-selective electrodes in environmental monitoring and wearable sensors | |
| CA2085322C (en) | Graphite based solid state polymeric membrane ion-selective electrodes | |
| JPH03503677A (ja) | 参照電極 | |
| US20090277805A1 (en) | Electrochemical sensors, sensor systems and method of sensing analytes | |
| Sanghavi et al. | Potentiometric stripping analysis of arsenic using a graphene paste electrode modified with a thiacrown ether and gold nanoparticles | |
| Singh et al. | Ready to use electrochemical sensor strip for point‐of‐care monitoring of serum lithium | |
| Bartoszewicz et al. | Calibration free solid contact electrodes with two PVC based membranes | |
| CN101765767B (zh) | 二氧化硅物质的电化学检测 | |
| JP2004537723A (ja) | ボルタンメトリーに用いるイオン選択性バイオセンサー | |
| Ali et al. | Development of novel potentiometric sensors for determination of lidocaine hydrochloride in pharmaceutical preparations, serum and urine samples | |
| EP3465193A1 (en) | REFERENCE ELECTRODE USING LOCAL ENVIRONMENT pH CONTROL | |
| Silva et al. | Ion-selective membrane modified microfluidic paper-based solution sampling substrates for potentiometric heavy metal detection | |
| Kałuża et al. | Solid‐contact ion‐selective electrodes paving the way for improved non‐zero current sensors: a minireview | |
| US7799204B2 (en) | Voltammetric Ion Sensor | |
| Svitková et al. | Electrochemical behavior of methylene blue at bare and DNA-modified silver solid amalgam electrodes | |
| AU2002317998A1 (en) | Voltammetric ion-selective biosensor | |
| Saghravanian et al. | Experimental sensing and density functional theory study of an ionic liquid mediated carbon nanotube modified carbon-paste electrode for electrochemical detection of metronidazole | |
| US11592414B2 (en) | Electrochemical sensor for detection and quantification of heavy metals | |
| Badr et al. | Highly selective single-use fluoride ion optical sensor based on aluminum (III)-salen complex in thin polymeric film | |
| Raja et al. | Fabrication of bismuth oxide-modified pencil graphite sensors for monitoring the hazardous herbicide diuron | |
| Shavokshina et al. | Improved performance of Prussian blue solid contact allowing flow injection amperometric detection of potassium ions in the excess of sodium |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050725 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050725 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20071225 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080324 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080331 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080422 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080430 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080523 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080530 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080617 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20081014 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090114 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090121 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090818 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20091117 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20091125 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091217 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091218 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100629 |