JP2004532389A5 - - Google Patents
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- Publication number
- JP2004532389A5 JP2004532389A5 JP2002563002A JP2002563002A JP2004532389A5 JP 2004532389 A5 JP2004532389 A5 JP 2004532389A5 JP 2002563002 A JP2002563002 A JP 2002563002A JP 2002563002 A JP2002563002 A JP 2002563002A JP 2004532389 A5 JP2004532389 A5 JP 2004532389A5
- Authority
- JP
- Japan
- Prior art keywords
- nitric oxide
- threshold
- subject
- level
- related product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 64
- 238000000034 method Methods 0.000 claims 40
- 206010052428 Wound Diseases 0.000 claims 16
- 208000027418 Wounds and injury Diseases 0.000 claims 16
- 230000029663 wound healing Effects 0.000 claims 9
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 8
- 229910002651 NO3 Inorganic materials 0.000 claims 8
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 235000012054 meals Nutrition 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 150000002826 nitrites Chemical class 0.000 claims 5
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims 4
- FBTSQILOGYXGMD-LURJTMIESA-N 3-nitro-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C([N+]([O-])=O)=C1 FBTSQILOGYXGMD-LURJTMIESA-N 0.000 claims 4
- 206010072170 Skin wound Diseases 0.000 claims 4
- 208000025865 Ulcer Diseases 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 4
- 229960002173 citrulline Drugs 0.000 claims 4
- ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 229910017464 nitrogen compound Inorganic materials 0.000 claims 4
- 150000002830 nitrogen compounds Chemical class 0.000 claims 4
- 230000036269 ulceration Effects 0.000 claims 4
- 201000002282 venous insufficiency Diseases 0.000 claims 4
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- UASRYODFRYWBRC-UHFFFAOYSA-N cGMP Natural products N1C(N)=NC(=O)C2=C1N(C1C3OP(O)(=O)OC3C(CO)O1)C=N2 UASRYODFRYWBRC-UHFFFAOYSA-N 0.000 claims 3
- 230000035876 healing Effects 0.000 claims 3
- LFLZOWIFJOBEPN-UHFFFAOYSA-N nitrate, nitrate Chemical group O[N+]([O-])=O.O[N+]([O-])=O LFLZOWIFJOBEPN-UHFFFAOYSA-N 0.000 claims 3
- 229930064664 L-arginine Natural products 0.000 claims 2
- 235000014852 L-arginine Nutrition 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 150000002823 nitrates Chemical class 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 150000002978 peroxides Chemical class 0.000 claims 1
- -1 peroxynitrate Chemical compound 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/776,926 US6436366B2 (en) | 1999-03-19 | 2001-02-06 | Prediction of wound healing by urinary nitrate assay |
| PCT/US2002/003204 WO2002063308A2 (en) | 2001-02-06 | 2002-02-05 | Prediction of wound healing by urinary nitrate assay |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004532389A JP2004532389A (ja) | 2004-10-21 |
| JP2004532389A5 true JP2004532389A5 (cg-RX-API-DMAC10.html) | 2005-12-22 |
Family
ID=25108752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563002A Pending JP2004532389A (ja) | 2001-02-06 | 2002-02-05 | 尿中硝酸塩測定による創傷治癒の予測 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6436366B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1360508B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2004532389A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE485523T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU2002245379B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2436465A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE60238032D1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2354868T3 (cg-RX-API-DMAC10.html) |
| MX (1) | MXPA03007018A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2002063308A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030134332A1 (en) * | 2001-11-28 | 2003-07-17 | Boykin Joseph V. | Diagnosis of endothelial dysfunction by nitric oxide bioactivity index |
| WO2004046155A2 (en) * | 2002-11-20 | 2004-06-03 | Boykin Jr Joseph V | Predicting outcome of hyperbaric oxygen therapy treatment with nitric oxide bioavailability |
| US8303995B1 (en) | 2008-06-13 | 2012-11-06 | Board Of Regents, The University Of Texas System | Nitrite formulations and their use as nitric oxide prodrugs |
| CA2844759A1 (en) * | 2011-08-11 | 2013-02-14 | Nathan S. Bryan | Method of measuring and monitoring in vivo nitrite levels |
| BR112014003414B1 (pt) | 2011-08-17 | 2021-09-21 | Board Of Regents, The University Of Texas System | Composição e sistema de entrega oral para aumento de níveis fisiológicos e terapêuticos de óxido nítrico |
| WO2015034967A2 (en) * | 2013-09-04 | 2015-03-12 | Microbaric Oxygen Systems, Llc | Hyperoxic therapy systems, methods and apparatus |
| US9492374B2 (en) | 2015-03-25 | 2016-11-15 | Jose Rafael Salinas Andrade | Composition and method for treatment of ulcers |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6312663B1 (en) * | 1999-03-19 | 2001-11-06 | Joseph V. Boykin, Jr. | Prediction of diabetes impaired wound healing by urinary nitrate assay |
-
2001
- 2001-02-06 US US09/776,926 patent/US6436366B2/en not_active Expired - Lifetime
-
2002
- 2002-02-05 EP EP02713532A patent/EP1360508B1/en not_active Expired - Lifetime
- 2002-02-05 WO PCT/US2002/003204 patent/WO2002063308A2/en not_active Ceased
- 2002-02-05 CA CA002436465A patent/CA2436465A1/en not_active Abandoned
- 2002-02-05 AT AT02713532T patent/ATE485523T1/de not_active IP Right Cessation
- 2002-02-05 AU AU2002245379A patent/AU2002245379B2/en not_active Expired
- 2002-02-05 JP JP2002563002A patent/JP2004532389A/ja active Pending
- 2002-02-05 MX MXPA03007018A patent/MXPA03007018A/es active IP Right Grant
- 2002-02-05 ES ES02713532T patent/ES2354868T3/es not_active Expired - Lifetime
- 2002-02-05 DE DE60238032T patent/DE60238032D1/de not_active Expired - Lifetime
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