JP2004529943A5 - - Google Patents
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- Publication number
- JP2004529943A5 JP2004529943A5 JP2002588757A JP2002588757A JP2004529943A5 JP 2004529943 A5 JP2004529943 A5 JP 2004529943A5 JP 2002588757 A JP2002588757 A JP 2002588757A JP 2002588757 A JP2002588757 A JP 2002588757A JP 2004529943 A5 JP2004529943 A5 JP 2004529943A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- alkoxycarbonyl
- optionally
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 27
- 229910052799 carbon Inorganic materials 0.000 claims description 24
- 229910052736 halogen Inorganic materials 0.000 claims description 22
- 150000002367 halogens Chemical class 0.000 claims description 22
- 125000001424 substituent group Chemical group 0.000 claims description 22
- -1 C 1 -C 4 alkoxy Chemical group 0.000 claims description 19
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims description 14
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 14
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 14
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 12
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 125000004076 pyridyl group Chemical group 0.000 claims description 8
- 125000004771 (C1-C4) haloalkylsulfinyl group Chemical group 0.000 claims description 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 6
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 230000002538 fungal effect Effects 0.000 claims description 6
- 239000000417 fungicide Substances 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 150000001204 N-oxides Chemical class 0.000 claims description 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 4
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 4
- 229930182558 Sterol Natural products 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 4
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims description 4
- 230000000855 fungicidal effect Effects 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 150000003432 sterols Chemical class 0.000 claims description 4
- 235000003702 sterols Nutrition 0.000 claims description 4
- XERJKGMBORTKEO-VZUCSPMQSA-N (1e)-2-(ethylcarbamoylamino)-n-methoxy-2-oxoethanimidoyl cyanide Chemical compound CCNC(=O)NC(=O)C(\C#N)=N\OC XERJKGMBORTKEO-VZUCSPMQSA-N 0.000 claims description 3
- 239000005756 Cymoxanil Substances 0.000 claims description 3
- AIPRFCIQHCXFQY-UHFFFAOYSA-N 2,6-dichloro-n-(3-methyl-5,6,7,8-tetrahydroquinolin-8-yl)benzamide Chemical compound C1CCC2=CC(C)=CN=C2C1NC(=O)C1=C(Cl)C=CC=C1Cl AIPRFCIQHCXFQY-UHFFFAOYSA-N 0.000 claims description 2
- VCMYXUVETJZCIH-UHFFFAOYSA-N 2-chloro-6-methoxy-n-(3-methyl-5,6,7,8-tetrahydroquinolin-8-yl)pyridine-4-carboxamide Chemical compound ClC1=NC(OC)=CC(C(=O)NC2C3=NC=C(C)C=C3CCC2)=C1 VCMYXUVETJZCIH-UHFFFAOYSA-N 0.000 claims description 2
- YCIPQJTZJGUXND-UHFFFAOYSA-N Aglaia odorata Alkaloid Natural products C1=CC(OC)=CC=C1C1(C(C=2C(=O)N3CCCC3=NC=22)C=3C=CC=CC=3)C2(O)C2=C(OC)C=C(OC)C=C2O1 YCIPQJTZJGUXND-UHFFFAOYSA-N 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims description 2
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- OIPMQULDKWSNGX-UHFFFAOYSA-N bis[[ethoxy(oxo)phosphaniumyl]oxy]alumanyloxy-ethoxy-oxophosphanium Chemical compound [Al+3].CCO[P+]([O-])=O.CCO[P+]([O-])=O.CCO[P+]([O-])=O OIPMQULDKWSNGX-UHFFFAOYSA-N 0.000 claims description 2
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000012990 dithiocarbamate Substances 0.000 claims description 2
- 244000053095 fungal pathogen Species 0.000 claims description 2
- 244000000004 fungal plant pathogen Species 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000002438 mitochondrial effect Effects 0.000 claims description 2
- 125000005543 phthalimide group Chemical class 0.000 claims description 2
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 150000003053 piperidines Chemical class 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 4
- 125000004414 alkyl thio group Chemical group 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 125000004438 haloalkoxy group Chemical group 0.000 description 4
- 125000001188 haloalkyl group Chemical group 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 description 2
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 description 2
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29088401P | 2001-05-15 | 2001-05-15 | |
| PCT/US2002/018394 WO2002091830A1 (en) | 2001-05-15 | 2002-05-14 | Pyridinyl fused bicyclic amide as fungicides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004529943A JP2004529943A (ja) | 2004-09-30 |
| JP2004529943A5 true JP2004529943A5 (https=) | 2006-01-05 |
Family
ID=23117917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002588757A Withdrawn JP2004529943A (ja) | 2001-05-15 | 2002-05-14 | 殺菌・殺カビ剤としてのピリジニル縮合二環式アミド |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1387612A1 (https=) |
| JP (1) | JP2004529943A (https=) |
| CN (1) | CN1509140A (https=) |
| AR (1) | AR033893A1 (https=) |
| BR (1) | BR0209687A (https=) |
| IL (1) | IL158009A0 (https=) |
| MX (1) | MXPA03010436A (https=) |
| PL (1) | PL367200A1 (https=) |
| RU (1) | RU2003136089A (https=) |
| WO (1) | WO2002091830A1 (https=) |
| ZA (1) | ZA200307375B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
| JP5034293B2 (ja) * | 2005-07-14 | 2012-09-26 | 住友化学株式会社 | カルボキサミド化合物及びこれを含有する植物病害防除剤 |
| US8044043B2 (en) * | 2008-04-11 | 2011-10-25 | Bristol-Myers Squibb Company | CGRP receptor antagonists |
| EP2435407B1 (en) | 2009-05-29 | 2019-12-25 | RaQualia Pharma Inc. | Aryl substituted carboxamide derivatives as calcium or sodium channel blockers |
| RU2743074C2 (ru) | 2014-08-01 | 2021-02-15 | Нуэволюшон А/С | Соединения, активные по отношению к бромодоменам |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| SMT202500271T1 (it) | 2020-07-02 | 2025-09-12 | Incyte Corp | Composti di urea triciclici come inibitori di v617f di jak2 |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
| AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
| CN114097792A (zh) * | 2021-11-25 | 2022-03-01 | 兰州大学 | 一种2，8-三氟甲基喹唑啉酮类化合物在防治农业植物病害中的用途 |
| CN119173514A (zh) | 2022-03-17 | 2024-12-20 | 因赛特公司 | 作为jak2 v617f抑制剂的三环脲化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69026395T2 (de) * | 1989-01-11 | 1997-03-06 | Agrevo Uk Ltd | Acrylat-Fungizide |
| AU2616595A (en) * | 1995-05-23 | 1996-12-11 | Hoechst Schering Agrevo Gmbh | Substituted 2,3-cycloalkenopyridines, process for preparing the same, agents containing the same and their use as pestic ides and fungicides |
| TW575562B (en) * | 1998-02-19 | 2004-02-11 | Agrevo Uk Ltd | Fungicides |
-
2002
- 2002-05-14 MX MXPA03010436A patent/MXPA03010436A/es unknown
- 2002-05-14 WO PCT/US2002/018394 patent/WO2002091830A1/en not_active Ceased
- 2002-05-14 RU RU2003136089/04A patent/RU2003136089A/ru not_active Application Discontinuation
- 2002-05-14 CN CNA028100646A patent/CN1509140A/zh active Pending
- 2002-05-14 BR BR0209687-0A patent/BR0209687A/pt not_active IP Right Cessation
- 2002-05-14 JP JP2002588757A patent/JP2004529943A/ja not_active Withdrawn
- 2002-05-14 EP EP02744275A patent/EP1387612A1/en not_active Withdrawn
- 2002-05-14 PL PL02367200A patent/PL367200A1/xx not_active Application Discontinuation
- 2002-05-14 IL IL15800902A patent/IL158009A0/xx unknown
- 2002-05-15 AR ARP020101792A patent/AR033893A1/es not_active Application Discontinuation
-
2003
- 2003-09-22 ZA ZA200307375A patent/ZA200307375B/en unknown
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